LSM3P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.08968706
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.08968706
3protein neddylation (GO:0045116)4.70890858
4regulation of hexokinase activity (GO:1903299)4.48383400
5regulation of glucokinase activity (GO:0033131)4.48383400
6cytochrome complex assembly (GO:0017004)4.40808769
7DNA damage response, detection of DNA damage (GO:0042769)4.28111242
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26178616
9regulation of germinal center formation (GO:0002634)3.89875399
10positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.89250556
11replication fork processing (GO:0031297)3.76295282
12S-adenosylmethionine metabolic process (GO:0046500)3.72773373
13kinetochore assembly (GO:0051382)3.72151934
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.65092835
15resolution of meiotic recombination intermediates (GO:0000712)3.61135715
16protein complex biogenesis (GO:0070271)3.59193334
17ATP synthesis coupled proton transport (GO:0015986)3.58172937
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58172937
19regulation of mitochondrial translation (GO:0070129)3.56710567
20negative regulation of transcription regulatory region DNA binding (GO:2000678)3.55296437
21protein K6-linked ubiquitination (GO:0085020)3.43965648
22kinetochore organization (GO:0051383)3.37584413
23meiotic chromosome segregation (GO:0045132)3.37115051
24chaperone-mediated protein transport (GO:0072321)3.32086896
25water-soluble vitamin biosynthetic process (GO:0042364)3.31774905
26cullin deneddylation (GO:0010388)3.29557250
27respiratory chain complex IV assembly (GO:0008535)3.29172775
28kynurenine metabolic process (GO:0070189)3.27876495
29DNA strand renaturation (GO:0000733)3.27839000
30seminiferous tubule development (GO:0072520)3.25155491
31microtubule depolymerization (GO:0007019)3.24987573
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22891971
33keratinocyte development (GO:0003334)3.22464434
34mitochondrial respiratory chain complex assembly (GO:0033108)3.21355858
35respiratory electron transport chain (GO:0022904)3.18371154
36presynaptic membrane assembly (GO:0097105)3.16337360
37electron transport chain (GO:0022900)3.16282732
38tryptophan catabolic process (GO:0006569)3.15135961
39indole-containing compound catabolic process (GO:0042436)3.15135961
40indolalkylamine catabolic process (GO:0046218)3.15135961
41acrosome assembly (GO:0001675)3.13695563
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09568225
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.09568225
44NADH dehydrogenase complex assembly (GO:0010257)3.09568225
45DNA replication checkpoint (GO:0000076)3.07168159
46platelet dense granule organization (GO:0060155)3.04400205
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04348768
48chromatin remodeling at centromere (GO:0031055)3.02152761
49L-ascorbic acid metabolic process (GO:0019852)3.01264798
50short-term memory (GO:0007614)2.99536085
51CENP-A containing nucleosome assembly (GO:0034080)2.97859239
52poly(A)+ mRNA export from nucleus (GO:0016973)2.96990167
53GTP biosynthetic process (GO:0006183)2.96638855
54negative regulation of DNA-dependent DNA replication (GO:2000104)2.96578308
55DNA double-strand break processing (GO:0000729)2.95915457
56presynaptic membrane organization (GO:0097090)2.94249495
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94221378
58protein deneddylation (GO:0000338)2.92774312
59L-fucose catabolic process (GO:0042355)2.91112367
60fucose catabolic process (GO:0019317)2.91112367
61L-fucose metabolic process (GO:0042354)2.91112367
62regulation of mesoderm development (GO:2000380)2.89547773
63positive regulation of dendritic spine morphogenesis (GO:0061003)2.86445688
64somite rostral/caudal axis specification (GO:0032525)2.84859838
65cellular response to gamma radiation (GO:0071480)2.82319401
66histone exchange (GO:0043486)2.80258218
67limb bud formation (GO:0060174)2.80224787
68cellular ketone body metabolic process (GO:0046950)2.79471410
69regulation of interferon-gamma biosynthetic process (GO:0045072)2.79061608
70amino acid salvage (GO:0043102)2.76716392
71L-methionine salvage (GO:0071267)2.76716392
72L-methionine biosynthetic process (GO:0071265)2.76716392
73mismatch repair (GO:0006298)2.76193756
74detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.74602320
75somite development (GO:0061053)2.73619311
76regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.73229872
77DNA deamination (GO:0045006)2.70810531
78cell migration involved in gastrulation (GO:0042074)2.70160093
79sequestering of actin monomers (GO:0042989)2.69532066
80protein-chromophore linkage (GO:0018298)2.68816474
81aldehyde catabolic process (GO:0046185)2.68669816
82white fat cell differentiation (GO:0050872)2.68171883
83limb development (GO:0060173)2.62678589
84appendage development (GO:0048736)2.62678589
85mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.62669109
86positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.62669109
87tryptophan metabolic process (GO:0006568)2.61792754
88negative regulation of DNA recombination (GO:0045910)2.61193735
89primitive streak formation (GO:0090009)2.61159830
90signal peptide processing (GO:0006465)2.59819732
91hydrogen ion transmembrane transport (GO:1902600)2.58039224
92DNA integration (GO:0015074)2.57817574
93mitochondrion transport along microtubule (GO:0047497)2.56326646
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56326646
95proton transport (GO:0015992)2.54972415
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.54151260
97negative regulation of telomere maintenance (GO:0032205)2.51928726
98reciprocal DNA recombination (GO:0035825)2.51864982
99reciprocal meiotic recombination (GO:0007131)2.51864982
100hydrogen transport (GO:0006818)2.51592736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.76777939
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24465749
3ZNF274_21170338_ChIP-Seq_K562_Hela2.88297713
4EZH2_22144423_ChIP-Seq_EOC_Human2.82432568
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.79122164
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.73136249
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70961494
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.69036915
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.59823056
10IGF1R_20145208_ChIP-Seq_DFB_Human2.58741827
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50485954
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46896649
13GBX2_23144817_ChIP-Seq_PC3_Human2.46532248
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36476107
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35250627
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.21821434
17P300_19829295_ChIP-Seq_ESCs_Human2.21398406
18ELK1_19687146_ChIP-ChIP_HELA_Human2.13906010
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99594278
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93056518
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89961778
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84238093
23EWS_26573619_Chip-Seq_HEK293_Human1.83921562
24ER_23166858_ChIP-Seq_MCF-7_Human1.76766641
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76007240
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74085302
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72609041
28FUS_26573619_Chip-Seq_HEK293_Human1.70528501
29BCAT_22108803_ChIP-Seq_LS180_Human1.69773699
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61396800
31CBP_20019798_ChIP-Seq_JUKART_Human1.61396800
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60777384
33MYC_18940864_ChIP-ChIP_HL60_Human1.60059191
34GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.57726116
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57164995
36VDR_23849224_ChIP-Seq_CD4+_Human1.50806511
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49185318
38AR_25329375_ChIP-Seq_VCAP_Human1.47704510
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45052337
40TCF4_22108803_ChIP-Seq_LS180_Human1.43232012
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43212983
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43193829
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.42807107
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.42105503
45NCOR_22424771_ChIP-Seq_293T_Human1.39782840
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39088092
47SOX2_19829295_ChIP-Seq_ESCs_Human1.38796593
48NANOG_19829295_ChIP-Seq_ESCs_Human1.38796593
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37918755
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37291810
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.35293798
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.35165694
53TP53_22573176_ChIP-Seq_HFKS_Human1.34831978
54TAF15_26573619_Chip-Seq_HEK293_Human1.33597717
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33113069
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32779174
57TCF4_23295773_ChIP-Seq_U87_Human1.32615697
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.29056470
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29056470
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.27191606
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24589496
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24170593
63SMAD4_21799915_ChIP-Seq_A2780_Human1.22889669
64FOXP3_21729870_ChIP-Seq_TREG_Human1.22882167
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22456104
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22134847
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20872297
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19657558
69JUN_21703547_ChIP-Seq_K562_Human1.19029955
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18580189
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17789789
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17520212
73RUNX2_22187159_ChIP-Seq_PCA_Human1.17147815
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.16283536
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.14534190
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14168792
77RNF2_27304074_Chip-Seq_NSC_Mouse1.14011623
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13349480
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13247164
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.13183505
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.13098906
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11984555
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.11526686
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11202743
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09718536
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.08095842
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07982510
88STAT3_23295773_ChIP-Seq_U87_Human1.07281598
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06998463
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06695909
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06676357
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06065139
93FOXH1_21741376_ChIP-Seq_EPCs_Human1.02872038
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02570578
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01503068
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.00074248
97CDX2_22108803_ChIP-Seq_LS180_Human0.99985805
98HTT_18923047_ChIP-ChIP_STHdh_Human0.99212446
99REST_21632747_ChIP-Seq_MESCs_Mouse0.98593483
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98573360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.45028200
2MP0003195_calcinosis3.05115102
3MP0008995_early_reproductive_senescence2.81889641
4MP0008877_abnormal_DNA_methylation2.77040718
5MP0002254_reproductive_system_inflammat2.76030135
6MP0006072_abnormal_retinal_apoptosis2.60544696
7MP0009384_cardiac_valve_regurgitation2.46530453
8MP0008057_abnormal_DNA_replication2.39767666
9MP0003122_maternal_imprinting2.32604844
10MP0005645_abnormal_hypothalamus_physiol2.28037736
11MP0003136_yellow_coat_color2.23261729
12MP0008058_abnormal_DNA_repair2.16268849
13MP0001486_abnormal_startle_reflex2.14717090
14MP0003283_abnormal_digestive_organ2.01460172
15MP0003121_genomic_imprinting1.99028759
16MP0003172_abnormal_lysosome_physiology1.97906756
17MP0002736_abnormal_nociception_after1.93533439
18MP0001529_abnormal_vocalization1.90345692
19MP0003890_abnormal_embryonic-extraembry1.87611977
20MP0004133_heterotaxia1.84819543
21MP0001984_abnormal_olfaction1.81155467
22MP0001764_abnormal_homeostasis1.80547053
23MP0005551_abnormal_eye_electrophysiolog1.79226138
24MP0003119_abnormal_digestive_system1.78676123
25MP0009046_muscle_twitch1.77687130
26MP0003011_delayed_dark_adaptation1.71015531
27MP0002138_abnormal_hepatobiliary_system1.67887012
28MP0003786_premature_aging1.65170284
29MP0005253_abnormal_eye_physiology1.62731588
30MP0003787_abnormal_imprinting1.62206772
31MP0008872_abnormal_physiological_respon1.57799065
32MP0003880_abnormal_central_pattern1.57740825
33MP0003718_maternal_effect1.55501577
34MP0005075_abnormal_melanosome_morpholog1.55057447
35MP0010094_abnormal_chromosome_stability1.54207112
36MP0004742_abnormal_vestibular_system1.52859116
37MP0003186_abnormal_redox_activity1.42603092
38MP0005646_abnormal_pituitary_gland1.38916264
39MP0000631_abnormal_neuroendocrine_gland1.38120855
40MP0000372_irregular_coat_pigmentation1.37657763
41MP0005084_abnormal_gallbladder_morpholo1.35183712
42MP0001968_abnormal_touch/_nociception1.34107408
43MP0004019_abnormal_vitamin_homeostasis1.33378005
44MP0003646_muscle_fatigue1.32878772
45MP0003137_abnormal_impulse_conducting1.31746635
46MP0002234_abnormal_pharynx_morphology1.29550016
47MP0004147_increased_porphyrin_level1.29178117
48MP0002557_abnormal_social/conspecific_i1.27247189
49MP0000778_abnormal_nervous_system1.23057770
50MP0009745_abnormal_behavioral_response1.22638007
51MP0001299_abnormal_eye_distance/1.21547782
52MP0002735_abnormal_chemical_nociception1.17685429
53MP0003937_abnormal_limbs/digits/tail_de1.16653059
54MP0008875_abnormal_xenobiotic_pharmacok1.16624385
55MP0005174_abnormal_tail_pigmentation1.14594815
56MP0002210_abnormal_sex_determination1.13527879
57MP0000566_synostosis1.12673279
58MP0001929_abnormal_gametogenesis1.11921092
59MP0002102_abnormal_ear_morphology1.11215704
60MP0005391_vision/eye_phenotype1.11101892
61MP0008004_abnormal_stomach_pH1.10455767
62MP0002272_abnormal_nervous_system1.06427791
63MP0002282_abnormal_trachea_morphology1.05456327
64MP0002938_white_spotting1.04608387
65MP0003567_abnormal_fetal_cardiomyocyte1.03073045
66MP0001293_anophthalmia1.03040216
67MP0003698_abnormal_male_reproductive1.02698417
68MP0001485_abnormal_pinna_reflex1.02604194
69MP0001501_abnormal_sleep_pattern0.99455355
70MP0000653_abnormal_sex_gland0.99251344
71MP0003693_abnormal_embryo_hatching0.98928739
72MP0004142_abnormal_muscle_tone0.98225403
73MP0004885_abnormal_endolymph0.93675789
74MP0006276_abnormal_autonomic_nervous0.91308065
75MP0001905_abnormal_dopamine_level0.89263809
76MP0002638_abnormal_pupillary_reflex0.88064557
77MP0005187_abnormal_penis_morphology0.86964269
78MP0001145_abnormal_male_reproductive0.86600202
79MP0002233_abnormal_nose_morphology0.84382428
80MP0001986_abnormal_taste_sensitivity0.83302299
81MP0004084_abnormal_cardiac_muscle0.83099440
82MP0005408_hypopigmentation0.81823605
83MP0000049_abnormal_middle_ear0.81223050
84MP0001286_abnormal_eye_development0.80209970
85MP0002572_abnormal_emotion/affect_behav0.79993707
86MP0004085_abnormal_heartbeat0.79560040
87MP0008789_abnormal_olfactory_epithelium0.78452414
88MP0000026_abnormal_inner_ear0.78063323
89MP0002184_abnormal_innervation0.76743504
90MP0002067_abnormal_sensory_capabilities0.76721379
91MP0006036_abnormal_mitochondrial_physio0.76647748
92MP0005195_abnormal_posterior_eye0.76384721
93MP0002752_abnormal_somatic_nervous0.75392326
94MP0002733_abnormal_thermal_nociception0.75276931
95MP0005499_abnormal_olfactory_system0.74847087
96MP0005394_taste/olfaction_phenotype0.74847087
97MP0005386_behavior/neurological_phenoty0.74499090
98MP0004924_abnormal_behavior0.74499090
99MP0005410_abnormal_fertilization0.74315499
100MP0002734_abnormal_mechanical_nocicepti0.74128146

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)3.95591177
2Colon cancer (HP:0003003)3.58013662
3Agammaglobulinemia (HP:0004432)3.57087457
43-Methylglutaconic aciduria (HP:0003535)3.56185587
5Chronic sinusitis (HP:0011109)3.23594411
6Pancreatic cysts (HP:0001737)3.14883916
7Methylmalonic acidemia (HP:0002912)3.13352007
8Acute encephalopathy (HP:0006846)3.09401142
9True hermaphroditism (HP:0010459)3.02006235
10Nephronophthisis (HP:0000090)3.01402016
11Acute necrotizing encephalopathy (HP:0006965)2.96747741
12Pendular nystagmus (HP:0012043)2.92430950
13Pancreatic fibrosis (HP:0100732)2.85487527
14Progressive macrocephaly (HP:0004481)2.83928355
15Abnormality of the renal cortex (HP:0011035)2.80791609
16Methylmalonic aciduria (HP:0012120)2.71262638
17Birth length less than 3rd percentile (HP:0003561)2.69489486
18Mitochondrial inheritance (HP:0001427)2.67758996
19Hyperglycinemia (HP:0002154)2.64027307
20Aqueductal stenosis (HP:0002410)2.53907654
21Increased CSF lactate (HP:0002490)2.53530523
22Abnormality of the labia minora (HP:0012880)2.52703764
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47668690
24Intestinal atresia (HP:0011100)2.47561956
25Abnormal mitochondria in muscle tissue (HP:0008316)2.45527663
26Abnormality of midbrain morphology (HP:0002418)2.42782857
27Molar tooth sign on MRI (HP:0002419)2.42782857
28Recurrent bronchitis (HP:0002837)2.39926693
29Limb hypertonia (HP:0002509)2.39005612
30Recurrent pneumonia (HP:0006532)2.38054111
31Anencephaly (HP:0002323)2.34996227
32Oligodactyly (hands) (HP:0001180)2.28945683
33Meckel diverticulum (HP:0002245)2.23657917
34Hepatocellular necrosis (HP:0001404)2.22456980
35Abnormality of the renal medulla (HP:0100957)2.20322858
36Increased serum pyruvate (HP:0003542)2.18959193
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.12331147
38Double outlet right ventricle (HP:0001719)2.12054272
39Congenital malformation of the right heart (HP:0011723)2.12054272
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11851505
41Abnormality of alanine metabolism (HP:0010916)2.11851505
42Hyperalaninemia (HP:0003348)2.11851505
43Severe visual impairment (HP:0001141)2.11480919
44Small hand (HP:0200055)2.09490808
45Meningioma (HP:0002858)2.08698033
46Optic disc pallor (HP:0000543)2.07645863
47Hepatic necrosis (HP:0002605)2.07211758
48Hyperglycinuria (HP:0003108)2.06704863
49Esophageal atresia (HP:0002032)2.05618423
50Spontaneous abortion (HP:0005268)2.01842814
51Gonadotropin excess (HP:0000837)2.01104952
52Hypoplastic female external genitalia (HP:0012815)2.00134147
53Growth hormone deficiency (HP:0000824)1.98302857
54Septo-optic dysplasia (HP:0100842)1.97803741
55Abnormality of the ileum (HP:0001549)1.97476865
56Congenital stationary night blindness (HP:0007642)1.97075621
57Sclerocornea (HP:0000647)1.96094743
58Long clavicles (HP:0000890)1.94376967
59Cerebral edema (HP:0002181)1.94063897
60Aplasia/Hypoplasia of the tongue (HP:0010295)1.91450335
61Asplenia (HP:0001746)1.90573078
62Abnormal rod and cone electroretinograms (HP:0008323)1.85570137
63Lipid accumulation in hepatocytes (HP:0006561)1.85298311
64Male pseudohermaphroditism (HP:0000037)1.84216664
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.83613877
66Decreased central vision (HP:0007663)1.82177527
67Abnormality of serine family amino acid metabolism (HP:0010894)1.81894847
68Abnormality of glycine metabolism (HP:0010895)1.81894847
69Abnormality of glycolysis (HP:0004366)1.81479692
70Tetany (HP:0001281)1.80872557
71Tracheal stenosis (HP:0002777)1.79766423
72Abnormality of vitamin B metabolism (HP:0004340)1.78479067
73Labial hypoplasia (HP:0000066)1.77648406
74Increased serum lactate (HP:0002151)1.77149297
75Increased hepatocellular lipid droplets (HP:0006565)1.77093451
76Gastrointestinal atresia (HP:0002589)1.76014627
77Optic nerve hypoplasia (HP:0000609)1.75924990
78Microvesicular hepatic steatosis (HP:0001414)1.75665779
79Inability to walk (HP:0002540)1.75440334
80J-shaped sella turcica (HP:0002680)1.74772494
81Increased corneal curvature (HP:0100692)1.74090528
82Keratoconus (HP:0000563)1.74090528
83Abnormality of chromosome stability (HP:0003220)1.72823613
84Medial flaring of the eyebrow (HP:0010747)1.72518139
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.71934845
86Bifid tongue (HP:0010297)1.71914113
87Abolished electroretinogram (ERG) (HP:0000550)1.71234989
88Abnormality of the parathyroid morphology (HP:0011766)1.71180222
89Horseshoe kidney (HP:0000085)1.70816490
90Abnormality of the vitamin B12 metabolism (HP:0004341)1.70660236
91Hepatosplenomegaly (HP:0001433)1.67136429
92Oligodactyly (HP:0012165)1.66630200
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66349382
94Stomach cancer (HP:0012126)1.65700099
95Chronic hepatic failure (HP:0100626)1.65553927
96Attenuation of retinal blood vessels (HP:0007843)1.64663410
97Irregular epiphyses (HP:0010582)1.64141754
98Progressive microcephaly (HP:0000253)1.63137825
99Anophthalmia (HP:0000528)1.62550587
100Chin dimple (HP:0010751)1.62290305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.25690613
2PINK13.79811208
3WNK33.36375967
4NUAK12.93218657
5MAP3K42.72621270
6PBK2.54825059
7MAP2K72.51867724
8MAPK132.47623047
9VRK22.41666275
10MST42.12431097
11PDK22.05249906
12NEK11.99213660
13WNK41.98061506
14GRK11.82550474
15EPHA41.71364641
16PKN11.70133448
17SRPK11.69743750
18MKNK21.66757458
19MAP3K61.57380975
20BMPR21.56773278
21VRK11.56560691
22CASK1.50321580
23CDC71.47168253
24STK391.45556476
25PLK31.43090227
26TRIM281.39166097
27BRSK21.35870039
28STK38L1.24290587
29CDK31.24186732
30ILK1.22828940
31PIK3CA1.18015149
32TNIK1.17052795
33PLK41.12221782
34OXSR11.11761133
35PAK31.10680135
36BMPR1B1.07367107
37ADRBK21.03833567
38EIF2AK31.01977244
39DYRK30.99642786
40PLK10.95201537
41WEE10.93685764
42INSRR0.92829075
43PLK20.92710334
44ERBB30.91771113
45CSNK1G10.88348055
46BRSK10.85449207
47EIF2AK10.84952980
48DYRK20.83508958
49TEC0.80135047
50MKNK10.72937555
51NTRK20.72733002
52MAP4K20.72563822
53PRKCE0.71824250
54MINK10.70941647
55CAMK2D0.70729815
56ZAK0.70703751
57DMPK0.65203506
58STK240.65030275
59DAPK30.64701612
60BUB10.62113528
61CCNB10.57920761
62DYRK1A0.57688037
63KIT0.56509258
64PRKCI0.55637857
65CSNK1G30.54455664
66FGFR20.54049264
67CSNK1G20.53358325
68TAF10.52303095
69EPHB20.51063315
70PRKCZ0.50295052
71ATR0.48839697
72TNK20.48756242
73DAPK10.48525432
74MAP2K40.48429524
75TLK10.48374177
76MAPK150.47356050
77MAP3K50.46699229
78STK160.46591902
79YES10.45210475
80PTK2B0.43743352
81MARK30.43509981
82PRKCG0.41941901
83TTK0.41808082
84ATM0.40837038
85PHKG10.39909525
86PHKG20.39909525
87MARK10.39839166
88CHEK20.39578906
89CAMK2B0.39236344
90SIK30.39014378
91ERBB40.38184971
92CAMK2A0.36638877
93PRKACA0.35388550
94CSNK2A10.32715389
95PRKG10.32451559
96ERBB20.32326436
97CSNK1E0.32013688
98CSNK1A1L0.31681327
99UHMK10.30437696
100CDK140.30303245

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.69824134
2Oxidative phosphorylation_Homo sapiens_hsa001903.41109645
3Non-homologous end-joining_Homo sapiens_hsa034503.29256460
4Homologous recombination_Homo sapiens_hsa034402.95211312
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67150316
6Parkinsons disease_Homo sapiens_hsa050122.62601286
7Propanoate metabolism_Homo sapiens_hsa006402.54094263
8Proteasome_Homo sapiens_hsa030502.40362525
9Butanoate metabolism_Homo sapiens_hsa006502.37827052
10Protein export_Homo sapiens_hsa030602.35825150
11Mismatch repair_Homo sapiens_hsa034302.26566443
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17817365
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14486127
14Fanconi anemia pathway_Homo sapiens_hsa034602.06500559
15Huntingtons disease_Homo sapiens_hsa050161.88659943
16Caffeine metabolism_Homo sapiens_hsa002321.84411310
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69142753
18Alzheimers disease_Homo sapiens_hsa050101.69099518
19RNA polymerase_Homo sapiens_hsa030201.67228382
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64196800
21Asthma_Homo sapiens_hsa053101.63436386
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.56722494
23Olfactory transduction_Homo sapiens_hsa047401.53965615
24Basal transcription factors_Homo sapiens_hsa030221.44453252
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.43760521
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42581823
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35151370
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29858491
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28981630
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.28835302
31Tryptophan metabolism_Homo sapiens_hsa003801.24876574
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20734422
33Collecting duct acid secretion_Homo sapiens_hsa049661.20141400
34Nucleotide excision repair_Homo sapiens_hsa034201.18583361
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18446590
36Base excision repair_Homo sapiens_hsa034101.13717488
37DNA replication_Homo sapiens_hsa030301.10716819
38Pyruvate metabolism_Homo sapiens_hsa006201.10664280
39Cardiac muscle contraction_Homo sapiens_hsa042601.09371408
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08958918
41RNA degradation_Homo sapiens_hsa030181.04668324
42Phototransduction_Homo sapiens_hsa047441.03060891
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02191254
44Linoleic acid metabolism_Homo sapiens_hsa005911.01359793
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99724795
46Chemical carcinogenesis_Homo sapiens_hsa052040.94459623
47Peroxisome_Homo sapiens_hsa041460.93473581
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91208007
49Fatty acid elongation_Homo sapiens_hsa000620.90376284
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87874584
51Nitrogen metabolism_Homo sapiens_hsa009100.84183599
52Rheumatoid arthritis_Homo sapiens_hsa053230.82617846
53Allograft rejection_Homo sapiens_hsa053300.82370157
54Autoimmune thyroid disease_Homo sapiens_hsa053200.81731957
55Steroid biosynthesis_Homo sapiens_hsa001000.81472757
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.81333961
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80037944
58Taste transduction_Homo sapiens_hsa047420.79843440
59Primary immunodeficiency_Homo sapiens_hsa053400.78648644
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76681583
61Vitamin digestion and absorption_Homo sapiens_hsa049770.76650232
62Graft-versus-host disease_Homo sapiens_hsa053320.74350617
63Glutathione metabolism_Homo sapiens_hsa004800.74063634
64Fatty acid degradation_Homo sapiens_hsa000710.72253815
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69504167
66Purine metabolism_Homo sapiens_hsa002300.69000276
67Metabolic pathways_Homo sapiens_hsa011000.68947801
68Fat digestion and absorption_Homo sapiens_hsa049750.67387434
69Pyrimidine metabolism_Homo sapiens_hsa002400.66574515
70Glycerolipid metabolism_Homo sapiens_hsa005610.65420893
71Ribosome_Homo sapiens_hsa030100.64857099
72RNA transport_Homo sapiens_hsa030130.59437324
73Type I diabetes mellitus_Homo sapiens_hsa049400.59124342
74Nicotine addiction_Homo sapiens_hsa050330.56729231
75beta-Alanine metabolism_Homo sapiens_hsa004100.52452933
76Folate biosynthesis_Homo sapiens_hsa007900.51978749
77Fatty acid metabolism_Homo sapiens_hsa012120.51504373
78One carbon pool by folate_Homo sapiens_hsa006700.49149960
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48454677
80Ether lipid metabolism_Homo sapiens_hsa005650.47173685
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45160178
82Circadian entrainment_Homo sapiens_hsa047130.43850453
83Lysine degradation_Homo sapiens_hsa003100.43254021
84Spliceosome_Homo sapiens_hsa030400.42258457
85Retinol metabolism_Homo sapiens_hsa008300.41807883
86Basal cell carcinoma_Homo sapiens_hsa052170.41135428
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37726984
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37236414
89Mineral absorption_Homo sapiens_hsa049780.34587830
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.33375606
91Ovarian steroidogenesis_Homo sapiens_hsa049130.33322549
92Synaptic vesicle cycle_Homo sapiens_hsa047210.32355234
93Wnt signaling pathway_Homo sapiens_hsa043100.31901944
94p53 signaling pathway_Homo sapiens_hsa041150.31042681
95Oocyte meiosis_Homo sapiens_hsa041140.30023172
96Arginine and proline metabolism_Homo sapiens_hsa003300.29889749
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29469873
98Hedgehog signaling pathway_Homo sapiens_hsa043400.28561419
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27756404
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26449576

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