LSM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.96751922
2DNA deamination (GO:0045006)5.76561834
3viral transcription (GO:0019083)5.67141957
4translational termination (GO:0006415)5.49110286
5DNA strand elongation involved in DNA replication (GO:0006271)5.03830931
6translational elongation (GO:0006414)4.98612371
7maturation of SSU-rRNA (GO:0030490)4.94567709
8telomere maintenance via semi-conservative replication (GO:0032201)4.87960253
9ribosomal small subunit biogenesis (GO:0042274)4.80319010
10DNA strand elongation (GO:0022616)4.77570022
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.65638489
12translational initiation (GO:0006413)4.53637640
13protein targeting to ER (GO:0045047)4.51862037
14cotranslational protein targeting to membrane (GO:0006613)4.51783496
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.49740321
16regulation of mitochondrial translation (GO:0070129)4.43809294
17DNA unwinding involved in DNA replication (GO:0006268)4.34351132
18viral life cycle (GO:0019058)4.34108809
19formation of translation preinitiation complex (GO:0001731)4.33705680
20DNA replication initiation (GO:0006270)4.32966122
21cellular protein complex disassembly (GO:0043624)4.29576238
22telomere maintenance via recombination (GO:0000722)4.29250447
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27904381
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.27378439
25protein localization to endoplasmic reticulum (GO:0070972)4.25182389
26ribosomal large subunit biogenesis (GO:0042273)4.21549525
27establishment of viral latency (GO:0019043)4.02907048
28mitotic recombination (GO:0006312)3.96910994
29protein complex disassembly (GO:0043241)3.91336506
30ribonucleoprotein complex biogenesis (GO:0022613)3.89490431
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.85367661
32L-serine metabolic process (GO:0006563)3.83193621
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81215772
34ATP synthesis coupled proton transport (GO:0015986)3.81215772
35pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.76281248
36pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.74473313
37telomere maintenance via telomere lengthening (GO:0010833)3.74078571
38DNA replication checkpoint (GO:0000076)3.73711721
39chaperone-mediated protein transport (GO:0072321)3.70414300
40macromolecular complex disassembly (GO:0032984)3.69286447
41protein maturation by protein folding (GO:0022417)3.68877190
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.66602593
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.63573891
44translation (GO:0006412)3.61896395
45peptidyl-arginine omega-N-methylation (GO:0035247)3.57483138
46pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.56835935
47spliceosomal snRNP assembly (GO:0000387)3.56400348
48protein localization to kinetochore (GO:0034501)3.54320037
49ribosome biogenesis (GO:0042254)3.52608084
50proteasome assembly (GO:0043248)3.51758352
51nucleobase biosynthetic process (GO:0046112)3.49368660
52mitotic chromosome condensation (GO:0007076)3.47535224
53* nuclear-transcribed mRNA catabolic process (GO:0000956)3.46586849
54rRNA processing (GO:0006364)3.45504345
55folic acid-containing compound biosynthetic process (GO:0009396)3.43201398
56pseudouridine synthesis (GO:0001522)3.41692707
57guanosine-containing compound biosynthetic process (GO:1901070)3.40587051
58chromatin remodeling at centromere (GO:0031055)3.38291926
59pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.37258418
60UTP biosynthetic process (GO:0006228)3.36777574
61rRNA metabolic process (GO:0016072)3.33220167
62histone arginine methylation (GO:0034969)3.32041726
63protein targeting to mitochondrion (GO:0006626)3.31866035
64establishment of integrated proviral latency (GO:0075713)3.31782063
65CENP-A containing nucleosome assembly (GO:0034080)3.31556619
66heterochromatin organization (GO:0070828)3.31454473
67protein localization to chromosome, centromeric region (GO:0071459)3.30019054
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28263842
69* mRNA catabolic process (GO:0006402)3.27932162
70mitotic nuclear envelope disassembly (GO:0007077)3.26932721
71CTP metabolic process (GO:0046036)3.26684719
72CTP biosynthetic process (GO:0006241)3.26684719
73oxidative phosphorylation (GO:0006119)3.25867344
74pyrimidine nucleotide catabolic process (GO:0006244)3.25220127
75DNA replication-dependent nucleosome organization (GO:0034723)3.23429091
76DNA replication-dependent nucleosome assembly (GO:0006335)3.23429091
77* RNA catabolic process (GO:0006401)3.22948698
78GTP biosynthetic process (GO:0006183)3.21758097
79rRNA modification (GO:0000154)3.21064399
80purine nucleobase biosynthetic process (GO:0009113)3.18926760
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18480711
822-deoxyribonucleotide biosynthetic process (GO:0009265)3.17631762
83deoxyribose phosphate biosynthetic process (GO:0046385)3.17631762
84regulation of translational fidelity (GO:0006450)3.17415287
85transcription-coupled nucleotide-excision repair (GO:0006283)3.16650909
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14957041
87deoxyribonucleotide biosynthetic process (GO:0009263)3.13602853
88DNA ligation (GO:0006266)3.13419517
89pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.13233897
90establishment of protein localization to mitochondrion (GO:0072655)3.11612193
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09653762
92spliceosomal complex assembly (GO:0000245)3.08526597
93respiratory electron transport chain (GO:0022904)3.07280571
94IMP biosynthetic process (GO:0006188)3.06208096
95mitotic metaphase plate congression (GO:0007080)3.05901952
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05117989
97DNA replication-independent nucleosome assembly (GO:0006336)3.05058358
98DNA replication-independent nucleosome organization (GO:0034724)3.05058358
99proline biosynthetic process (GO:0006561)3.04239474
100UTP metabolic process (GO:0046051)3.04207213
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02401099
102negative regulation of ligase activity (GO:0051352)3.02401099
103negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02378236
104kinetochore organization (GO:0051383)3.01636140
105negative regulation of RNA splicing (GO:0033119)3.01464001
106protein localization to mitochondrion (GO:0070585)3.00478477
107cellular component biogenesis (GO:0044085)2.99139581
108regulation of protein heterodimerization activity (GO:0043497)2.98760564
109electron transport chain (GO:0022900)2.98201879
110membrane disassembly (GO:0030397)2.97773044
111nuclear envelope disassembly (GO:0051081)2.97773044
112deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95844612
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95306448
114base-excision repair, AP site formation (GO:0006285)2.93424370
115nuclear envelope reassembly (GO:0031468)2.92986477
116ribosome assembly (GO:0042255)2.92308458
117protein targeting to membrane (GO:0006612)2.91756268
118kinetochore assembly (GO:0051382)2.91105564
119termination of RNA polymerase II transcription (GO:0006369)2.88100826
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87942242
121mRNA splicing, via spliceosome (GO:0000398)2.87942242
122RNA splicing, via transesterification reactions (GO:0000375)2.87456267
123pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84271411
124viral mRNA export from host cell nucleus (GO:0046784)2.83183570
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81279910
126mitotic sister chromatid segregation (GO:0000070)2.80772992
127cell cycle G1/S phase transition (GO:0044843)2.80758902
128G1/S transition of mitotic cell cycle (GO:0000082)2.80758902
129telomere organization (GO:0032200)2.77851713
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77605843
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77605843
132telomere maintenance (GO:0000723)2.77037549
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75235291
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75235291
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75235291
136IMP metabolic process (GO:0046040)2.75222258
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.72910504
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72910504
139base-excision repair (GO:0006284)2.72797824
140nucleobase-containing small molecule interconversion (GO:0015949)2.68834240
141signal transduction involved in cell cycle checkpoint (GO:0072395)2.68185854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07603894
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.22963613
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.19886813
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.28263041
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98452290
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92539647
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87480712
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.79261756
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.77936802
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77112244
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75270439
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73292397
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69448472
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.66741241
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52165801
16XRN2_22483619_ChIP-Seq_HELA_Human2.44541613
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41875054
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39973584
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23777111
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15909654
21* VDR_23849224_ChIP-Seq_CD4+_Human2.08905994
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05814894
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00729344
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98378301
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96300573
26MYC_22102868_ChIP-Seq_BL_Human1.95842054
27DCP1A_22483619_ChIP-Seq_HELA_Human1.92607195
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92359456
29FOXP3_21729870_ChIP-Seq_TREG_Human1.89283948
30* GABP_19822575_ChIP-Seq_HepG2_Human1.89262592
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85183918
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81843046
33TTF2_22483619_ChIP-Seq_HELA_Human1.81062968
34CIITA_25753668_ChIP-Seq_RAJI_Human1.76552080
35ZNF263_19887448_ChIP-Seq_K562_Human1.76040058
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72771971
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66394914
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.63903705
39* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63629228
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.63063869
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62599400
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62198821
43VDR_21846776_ChIP-Seq_THP-1_Human1.60740526
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59457905
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56214580
46AR_21909140_ChIP-Seq_LNCAP_Human1.55335527
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53519097
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50174206
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48219662
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.46261656
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45786560
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44788898
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.40788611
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39793700
55* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39777558
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33901105
57KDM5A_27292631_Chip-Seq_BREAST_Human1.33452666
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33123423
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32891119
60* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26175973
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.25052926
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24342748
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24128810
64ELK1_19687146_ChIP-ChIP_HELA_Human1.23428587
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23379837
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23057769
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21013425
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20948867
69* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20543687
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20025283
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17542502
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17481747
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14759600
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12073812
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11051218
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09672248
77* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09669542
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08101886
79TFEB_21752829_ChIP-Seq_HELA_Human1.07761492
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04828470
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.04647159
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03315795
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03310015
84* SPI1_23547873_ChIP-Seq_NB4_Human1.03082008
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02188803
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01452280
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00226008
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99691774
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.98105211
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97337445
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96256232
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95031225
93P68_20966046_ChIP-Seq_HELA_Human0.93660757
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93650370
95* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93584091
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93549858
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93035985
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91835904
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91716679
100MYC_18940864_ChIP-ChIP_HL60_Human0.91026188
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90604371
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.90356615
103* LXR_22292898_ChIP-Seq_THP-1_Human0.89951162
104* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89528616
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88787699
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88423402
107MAF_26560356_Chip-Seq_TH2_Human0.88042382
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87433680
109* UTX_26944678_Chip-Seq_JUKART_Human0.87359258
110MAF_26560356_Chip-Seq_TH1_Human0.86776551
111* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84131807
112FOXP1_21924763_ChIP-Seq_HESCs_Human0.83661182
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83623210
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83286733
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82916417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.41638733
2MP0004957_abnormal_blastocyst_morpholog4.42226819
3MP0003111_abnormal_nucleus_morphology4.08572567
4MP0010094_abnormal_chromosome_stability3.98882897
5MP0003077_abnormal_cell_cycle3.81731377
6MP0008057_abnormal_DNA_replication3.06478472
7MP0008058_abnormal_DNA_repair2.87078948
8MP0008007_abnormal_cellular_replicative2.70774642
9MP0002396_abnormal_hematopoietic_system2.49969493
10MP0008932_abnormal_embryonic_tissue2.46596313
11MP0000490_abnormal_crypts_of2.32310697
12MP0001730_embryonic_growth_arrest2.18957736
13MP0000350_abnormal_cell_proliferation2.05739998
14MP0010352_gastrointestinal_tract_polyps2.02598651
15MP0009333_abnormal_splenocyte_physiolog1.98516606
16MP0003763_abnormal_thymus_physiology1.95275716
17MP0003123_paternal_imprinting1.94408732
18MP0003786_premature_aging1.72189966
19MP0003806_abnormal_nucleotide_metabolis1.70185791
20MP0002019_abnormal_tumor_incidence1.65527810
21MP0005451_abnormal_body_composition1.64033227
22MP0000313_abnormal_cell_death1.61807151
23MP0001545_abnormal_hematopoietic_system1.59308528
24MP0005397_hematopoietic_system_phenotyp1.59308528
25MP0001697_abnormal_embryo_size1.58981027
26* MP0002080_prenatal_lethality1.54925784
27MP0008789_abnormal_olfactory_epithelium1.54811947
28MP0004808_abnormal_hematopoietic_stem1.54754607
29MP0004858_abnormal_nervous_system1.53412882
30MP0002398_abnormal_bone_marrow1.52734554
31MP0009379_abnormal_foot_pigmentation1.50073162
32MP0005380_embryogenesis_phenotype1.46897475
33MP0001672_abnormal_embryogenesis/_devel1.46897475
34MP0010030_abnormal_orbit_morphology1.46811151
35MP0009672_abnormal_birth_weight1.46627360
36MP0000858_altered_metastatic_potential1.43852458
37MP0000703_abnormal_thymus_morphology1.43298609
38MP0002722_abnormal_immune_system1.42148546
39MP0009697_abnormal_copulation1.39412202
40MP0000049_abnormal_middle_ear1.36110580
41MP0005501_abnormal_skin_physiology1.35415935
42MP0000689_abnormal_spleen_morphology1.35253343
43MP0003984_embryonic_growth_retardation1.34025698
44MP0002132_abnormal_respiratory_system1.32615840
45MP0002085_abnormal_embryonic_tissue1.32050136
46MP0002088_abnormal_embryonic_growth/wei1.29645660
47MP0006054_spinal_hemorrhage1.28938264
48MP0005394_taste/olfaction_phenotype1.28810346
49MP0005499_abnormal_olfactory_system1.28810346
50MP0004233_abnormal_muscle_weight1.27823301
51MP0002877_abnormal_melanocyte_morpholog1.27444231
52MP0000685_abnormal_immune_system1.26722810
53MP0001727_abnormal_embryo_implantation1.24628851
54MP0002429_abnormal_blood_cell1.23538279
55MP0010307_abnormal_tumor_latency1.23386960
56MP0002086_abnormal_extraembryonic_tissu1.21234059
57MP0001529_abnormal_vocalization1.17670191
58MP0001346_abnormal_lacrimal_gland1.17465962
59MP0002653_abnormal_ependyma_morphology1.16931441
60MP0002163_abnormal_gland_morphology1.14752206
61MP0002697_abnormal_eye_size1.14318452
62MP0008877_abnormal_DNA_methylation1.14205735
63MP0003186_abnormal_redox_activity1.13854367
64MP0003567_abnormal_fetal_cardiomyocyte1.11530384
65MP0000716_abnormal_immune_system1.09635284
66MP0002084_abnormal_developmental_patter1.09579459
67MP0001835_abnormal_antigen_presentation1.08318397
68MP0004197_abnormal_fetal_growth/weight/1.08209514
69MP0006036_abnormal_mitochondrial_physio1.06200037
70MP0000358_abnormal_cell_content/1.05891646
71MP0001853_heart_inflammation1.03762553
72MP0003315_abnormal_perineum_morphology1.03039983
73MP0002234_abnormal_pharynx_morphology1.02380784
74MP0006292_abnormal_olfactory_placode1.01513162
75MP0008260_abnormal_autophagy1.00283981
76MP0001800_abnormal_humoral_immune0.99003452
77MP0001293_anophthalmia0.98936671
78MP0003937_abnormal_limbs/digits/tail_de0.97879761
79MP0004185_abnormal_adipocyte_glucose0.96463225
80MP0002210_abnormal_sex_determination0.96057607
81MP0005671_abnormal_response_to0.94925609
82MP0002938_white_spotting0.94544018
83MP0003718_maternal_effect0.94467244
84MP0009053_abnormal_anal_canal0.94306830
85MP0009278_abnormal_bone_marrow0.93938032
86MP0004133_heterotaxia0.93382319
87MP0005075_abnormal_melanosome_morpholog0.93306621
88MP0001661_extended_life_span0.93215968
89MP0002420_abnormal_adaptive_immunity0.93112389
90MP0001188_hyperpigmentation0.92785725
91MP0004147_increased_porphyrin_level0.92729279
92MP0000477_abnormal_intestine_morphology0.92580347
93MP0002405_respiratory_system_inflammati0.92059203
94MP0001819_abnormal_immune_cell0.91730256
95MP0003119_abnormal_digestive_system0.89511940
96MP0002249_abnormal_larynx_morphology0.86833067
97MP0002452_abnormal_antigen_presenting0.85990169
98MP0005076_abnormal_cell_differentiation0.85405730
99MP0010155_abnormal_intestine_physiology0.85121299
100MP0005623_abnormal_meninges_morphology0.84867762
101MP0001145_abnormal_male_reproductive0.84729849
102MP0003866_abnormal_defecation0.84309247
103MP0002092_abnormal_eye_morphology0.83469290
104MP0000566_synostosis0.82484367
105MP0005174_abnormal_tail_pigmentation0.81548724
106MP0003941_abnormal_skin_development0.81185221
107MP0002723_abnormal_immune_serum0.80760715
108MP0002233_abnormal_nose_morphology0.80303890
109MP0002160_abnormal_reproductive_system0.79599375
110MP0005025_abnormal_response_to0.79237040
111MP0003942_abnormal_urinary_system0.78644756
112MP0001881_abnormal_mammary_gland0.78202307
113MP0009785_altered_susceptibility_to0.77820268
114MP0003656_abnormal_erythrocyte_physiolo0.77097955
115MP0006035_abnormal_mitochondrial_morpho0.76741546
116MP0005023_abnormal_wound_healing0.75943537
117MP0003385_abnormal_body_wall0.75352615
118MP0000750_abnormal_muscle_regeneration0.74464842
119MP0001286_abnormal_eye_development0.72589675
120MP0003861_abnormal_nervous_system0.71249410
121MP0005384_cellular_phenotype0.69604962
122MP0003436_decreased_susceptibility_to0.69511107
123MP0000372_irregular_coat_pigmentation0.69407151
124MP0001873_stomach_inflammation0.68637967
125MP0003136_yellow_coat_color0.68341165
126MP0003221_abnormal_cardiomyocyte_apopto0.67533880
127MP0001929_abnormal_gametogenesis0.66865114
128MP0000653_abnormal_sex_gland0.65848482
129MP0003121_genomic_imprinting0.64091009
130MP0005000_abnormal_immune_tolerance0.63718550
131MP0000537_abnormal_urethra_morphology0.63500057
132MP0001119_abnormal_female_reproductive0.63487242
133MP0001849_ear_inflammation0.61988047
134MP0003122_maternal_imprinting0.61975660
135MP0002111_abnormal_tail_morphology0.61933372
136MP0001905_abnormal_dopamine_level0.61512578
137MP0002006_tumorigenesis0.61287317
138MP0002736_abnormal_nociception_after0.61150729
139MP0000762_abnormal_tongue_morphology0.61108171
140MP0000678_abnormal_parathyroid_gland0.60906984
141MP0005266_abnormal_metabolism0.60780610
142MP0003938_abnormal_ear_development0.60774281
143MP0005389_reproductive_system_phenotype0.60507192
144MP0001919_abnormal_reproductive_system0.60268859
145MP0005330_cardiomyopathy0.59196989

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.89184684
2Reticulocytopenia (HP:0001896)5.81934859
3Abnormal number of erythroid precursors (HP:0012131)5.71888919
4Acute necrotizing encephalopathy (HP:0006965)4.14910669
5Microvesicular hepatic steatosis (HP:0001414)4.02571014
6Pallor (HP:0000980)3.95713935
7Acute encephalopathy (HP:0006846)3.89151817
8Oral leukoplakia (HP:0002745)3.86876621
9Macrocytic anemia (HP:0001972)3.76777553
10Aplastic anemia (HP:0001915)3.71731416
11Birth length less than 3rd percentile (HP:0003561)3.68625869
12Colon cancer (HP:0003003)3.31122780
13Selective tooth agenesis (HP:0001592)3.24738942
14Cerebral edema (HP:0002181)3.19892916
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18633489
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18633489
17Abnormality of glycolysis (HP:0004366)3.18042243
18Increased hepatocellular lipid droplets (HP:0006565)3.11642925
19Microretrognathia (HP:0000308)3.10537859
20Breast hypoplasia (HP:0003187)3.07866529
21Increased serum pyruvate (HP:0003542)3.04776710
22Ragged-red muscle fibers (HP:0003200)3.04261159
23Increased muscle lipid content (HP:0009058)3.03443128
24Rough bone trabeculation (HP:0100670)2.99167486
25Progressive macrocephaly (HP:0004481)2.98790869
26Degeneration of anterior horn cells (HP:0002398)2.97780778
27Abnormality of the anterior horn cell (HP:0006802)2.97780778
28Absent thumb (HP:0009777)2.96622101
29Lipid accumulation in hepatocytes (HP:0006561)2.94627496
30Trismus (HP:0000211)2.93106295
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.92002543
32Lactic acidosis (HP:0003128)2.90199530
33Exercise intolerance (HP:0003546)2.90176091
34Multiple enchondromatosis (HP:0005701)2.85050853
35Carpal bone hypoplasia (HP:0001498)2.83076689
3611 pairs of ribs (HP:0000878)2.78261823
37Thrombocytosis (HP:0001894)2.71015814
38Progressive muscle weakness (HP:0003323)2.68251494
39Abnormality of reticulocytes (HP:0004312)2.66139862
40Meckel diverticulum (HP:0002245)2.62840674
41Patellar aplasia (HP:0006443)2.59713933
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.59164607
43Abnormality of the preputium (HP:0100587)2.58364897
44Abnormality of the ileum (HP:0001549)2.55633925
45Broad distal phalanx of finger (HP:0009836)2.52969902
46Chromsome breakage (HP:0040012)2.49075599
47Aplasia/Hypoplasia of the patella (HP:0006498)2.47410717
48Abnormal number of incisors (HP:0011064)2.45124114
49Increased serum lactate (HP:0002151)2.44226092
50Neoplasm of the pancreas (HP:0002894)2.42135455
51Testicular atrophy (HP:0000029)2.41591334
52IgM deficiency (HP:0002850)2.40798339
53Premature graying of hair (HP:0002216)2.40767044
54Renal Fanconi syndrome (HP:0001994)2.37771338
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37142229
56Hepatocellular necrosis (HP:0001404)2.34830756
57Medulloblastoma (HP:0002885)2.34177107
58Cerebral hypomyelination (HP:0006808)2.33675506
59Ependymoma (HP:0002888)2.32563040
60Myelodysplasia (HP:0002863)2.32429536
61Hyperglycinemia (HP:0002154)2.31252285
62Basal cell carcinoma (HP:0002671)2.28392040
63Respiratory failure (HP:0002878)2.28364029
64Respiratory difficulties (HP:0002880)2.26955958
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.24817098
66Abnormality of chromosome stability (HP:0003220)2.24677741
67Type I transferrin isoform profile (HP:0003642)2.24233970
68Reduced antithrombin III activity (HP:0001976)2.23625105
69Bone marrow hypocellularity (HP:0005528)2.23567482
70Facial cleft (HP:0002006)2.23508463
71Pancytopenia (HP:0001876)2.23175123
72Cellular immunodeficiency (HP:0005374)2.19058439
73Tracheoesophageal fistula (HP:0002575)2.15497473
74Hepatic necrosis (HP:0002605)2.14389715
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13589158
76Premature ovarian failure (HP:0008209)2.08153548
77Small intestinal stenosis (HP:0012848)2.07861918
78Duodenal stenosis (HP:0100867)2.07861918
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06860382
80Leukodystrophy (HP:0002415)2.06256724
81Poikiloderma (HP:0001029)2.05533345
82Petechiae (HP:0000967)2.05333656
83Abnormal trabecular bone morphology (HP:0100671)2.03152770
84Rectal prolapse (HP:0002035)2.02079084
85Agnosia (HP:0010524)2.01919049
86Horseshoe kidney (HP:0000085)2.01617471
87Triphalangeal thumb (HP:0001199)2.00899544
88Missing ribs (HP:0000921)1.99635604
89Lymphoma (HP:0002665)1.99554484
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97172061
91Abnormal gallbladder physiology (HP:0012438)1.96371738
92Cholecystitis (HP:0001082)1.96371738
93Mitochondrial inheritance (HP:0001427)1.94093875
94Muscle fiber atrophy (HP:0100295)1.93782224
95Cleft eyelid (HP:0000625)1.92820835
96Increased CSF lactate (HP:0002490)1.91895937
97Secondary amenorrhea (HP:0000869)1.90210220
98Absent radius (HP:0003974)1.89461635
99Emotional lability (HP:0000712)1.89258370
100Hypoplastic pelvis (HP:0008839)1.88807618
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88784310
102Absent epiphyses (HP:0010577)1.88784310
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.87855984
104High anterior hairline (HP:0009890)1.87482513
105Optic nerve coloboma (HP:0000588)1.86358293
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86346962
107Dicarboxylic aciduria (HP:0003215)1.86346962
108Rhabdomyosarcoma (HP:0002859)1.83990598
109Gout (HP:0001997)1.81424021
110Elevated erythrocyte sedimentation rate (HP:0003565)1.80833959
111Sloping forehead (HP:0000340)1.79825035
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78798907
113Acute lymphatic leukemia (HP:0006721)1.76584435
114Exertional dyspnea (HP:0002875)1.76113238
115Squamous cell carcinoma (HP:0002860)1.75634051
116Abnormality of T cell physiology (HP:0011840)1.75580392
117Angiofibromas (HP:0010615)1.75470990
118Adenoma sebaceum (HP:0009720)1.75470990
119Abnormal mitochondria in muscle tissue (HP:0008316)1.75014146
120Lethargy (HP:0001254)1.74372004
121Sparse eyelashes (HP:0000653)1.74105666
122Dysphonia (HP:0001618)1.73766971
123Abnormality of the umbilical cord (HP:0010881)1.73683486
124Aplasia involving forearm bones (HP:0009822)1.73397761
125Absent forearm bone (HP:0003953)1.73397761
1263-Methylglutaconic aciduria (HP:0003535)1.73345364
127Proximal placement of thumb (HP:0009623)1.73278096
128Slender long bone (HP:0003100)1.73140329
129Neoplasm of the colon (HP:0100273)1.72996485
130Atresia of the external auditory canal (HP:0000413)1.72623519
131Increased nuchal translucency (HP:0010880)1.71615254
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71162703
133Abnormal protein N-linked glycosylation (HP:0012347)1.71162703
134Abnormal protein glycosylation (HP:0012346)1.71162703
135Abnormal glycosylation (HP:0012345)1.71162703
136Abnormality of T cells (HP:0002843)1.70343125
137Increased intramyocellular lipid droplets (HP:0012240)1.70342653
138Hypoplasia of the radius (HP:0002984)1.69608830
139Abnormality of pyrimidine metabolism (HP:0004353)1.68094983
140Spastic diplegia (HP:0001264)1.66223031
141Duplication of thumb phalanx (HP:0009942)1.65091621
142Death in infancy (HP:0001522)1.62930419
143Calcaneovalgus deformity (HP:0001848)1.62616735
144Overriding aorta (HP:0002623)1.62588161
145Insomnia (HP:0100785)1.61519951
146Myopathic facies (HP:0002058)1.58823827
147Abnormality of cochlea (HP:0000375)1.56444593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.91169851
2VRK24.49379401
3NME23.50587089
4WEE13.50059474
5CDC73.00155896
6EIF2AK12.63484572
7STK162.55073131
8TESK22.52628584
9NEK22.44654884
10RPS6KA42.43556641
11SMG12.32474459
12TLK12.28739079
13ACVR1B2.08285149
14MAP4K12.06954956
15KDR1.99502035
16MAP3K101.89891136
17SRPK11.87789248
18VRK11.86740873
19DYRK31.81433104
20ARAF1.79313494
21NEK11.71068377
22TTK1.69352106
23RPS6KB21.66213702
24CDK71.66060171
25PLK11.62006208
26ZAK1.61640397
27EEF2K1.60631286
28MAP3K111.55846661
29LIMK11.53044349
30PIM21.50461692
31PASK1.50451396
32AURKB1.49500895
33SCYL21.47250149
34BRSK21.41514337
35ATR1.35924146
36EIF2AK31.33616052
37PAK41.30233429
38TESK11.28438882
39CDK41.27900393
40PLK41.27633421
41LRRK21.27348497
42MAP3K81.25589021
43PDK21.24872740
44STK101.23852294
45PKN21.23381763
46AURKA1.21964817
47TSSK61.14671153
48BRSK11.11561369
49BCKDK1.11498147
50CSNK1G31.09630892
51TGFBR11.08792133
52EPHA21.07580647
53CHEK21.06882030
54FLT31.05878302
55MAPKAPK31.00811023
56IRAK30.99047875
57TAF10.97972166
58BLK0.97374727
59ZAP700.96322626
60STK40.92079458
61DYRK20.91316584
62ILK0.90790204
63CCNB10.89947164
64BTK0.88324489
65TRIB30.87137084
66MKNK10.86022450
67CHEK10.85542766
68CDK120.85481853
69PIM10.81051942
70CSNK1A1L0.78883548
71GRK60.77171543
72TYK20.76173667
73CDK11A0.73948722
74NME10.73773368
75CDK140.71641309
76MAP2K30.70829230
77MAP2K70.68218352
78CSNK1G10.68087832
79CDK150.67857754
80PAK10.67425819
81ERN10.67366241
82ICK0.66572657
83CSNK2A10.65461981
84CDK180.64819430
85CSNK1G20.64461957
86RPS6KA50.64335725
87CDK190.63671867
88CSNK2A20.63238089
89CDK20.60604392
90CDK80.57546433
91BRAF0.55626629
92PLK30.53388843
93TRIM280.51852808
94PRKCI0.50311909
95TBK10.49553952
96MKNK20.47201919
97MAPKAPK50.46852814
98ATM0.45137196
99PRKD30.42586337
100AKT20.42445326
101MST1R0.41670941
102CDK60.40965380
103PBK0.39641784
104JAK30.39271082
105TEC0.38183393
106MAP2K20.37197235
107CSF1R0.36036008
108MAPK110.35948944
109ABL20.35863393
110IKBKB0.34640437
111MAPKAPK20.33454396
112DAPK30.33388385
113CLK10.33307441
114ALK0.33167724
115RPS6KA10.32722846
116TAOK20.32685176
117CDK10.32320821
118MAP3K120.31739789
119EIF2AK20.31624617
120KIT0.30636511
121DAPK10.30543023
122LYN0.30232835
123TXK0.29284314
124MINK10.28738803
125ERBB40.28297424
126IRAK40.28239606
127CSNK1E0.27904196
128BMX0.25796982
129CDK90.24531364
130PRKDC0.20587019

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.19588311
2Ribosome_Homo sapiens_hsa030104.90839480
3Mismatch repair_Homo sapiens_hsa034304.19361427
4Proteasome_Homo sapiens_hsa030503.44253841
5* Spliceosome_Homo sapiens_hsa030403.34931786
6Base excision repair_Homo sapiens_hsa034103.25579424
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99126775
8Homologous recombination_Homo sapiens_hsa034402.96634095
9RNA polymerase_Homo sapiens_hsa030202.94458851
10Nucleotide excision repair_Homo sapiens_hsa034202.68851594
11RNA transport_Homo sapiens_hsa030132.62234474
12Pyrimidine metabolism_Homo sapiens_hsa002402.58027008
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23259419
14Cell cycle_Homo sapiens_hsa041102.21573824
15One carbon pool by folate_Homo sapiens_hsa006702.20065396
16Fanconi anemia pathway_Homo sapiens_hsa034601.83034120
17* RNA degradation_Homo sapiens_hsa030181.54571432
18Non-homologous end-joining_Homo sapiens_hsa034501.53798797
19Fatty acid elongation_Homo sapiens_hsa000621.49005457
20Pyruvate metabolism_Homo sapiens_hsa006201.45716283
21p53 signaling pathway_Homo sapiens_hsa041151.41361314
22mRNA surveillance pathway_Homo sapiens_hsa030151.39894586
23Sulfur relay system_Homo sapiens_hsa041221.38319520
24Basal transcription factors_Homo sapiens_hsa030221.36930154
25Purine metabolism_Homo sapiens_hsa002301.25191192
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24657271
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17915631
28Parkinsons disease_Homo sapiens_hsa050121.14811211
29Pentose phosphate pathway_Homo sapiens_hsa000301.14699666
30Primary immunodeficiency_Homo sapiens_hsa053401.14220269
31Systemic lupus erythematosus_Homo sapiens_hsa053221.08812526
32Folate biosynthesis_Homo sapiens_hsa007901.07852055
33Epstein-Barr virus infection_Homo sapiens_hsa051691.06392142
34Vitamin B6 metabolism_Homo sapiens_hsa007501.02325560
35Huntingtons disease_Homo sapiens_hsa050161.01309860
36Herpes simplex infection_Homo sapiens_hsa051680.99693112
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96028880
38Antigen processing and presentation_Homo sapiens_hsa046120.95280154
39Biosynthesis of amino acids_Homo sapiens_hsa012300.91854044
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88169422
41Oxidative phosphorylation_Homo sapiens_hsa001900.86265121
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.80429252
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.80228711
44Protein export_Homo sapiens_hsa030600.79975309
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78511922
46Viral carcinogenesis_Homo sapiens_hsa052030.76436862
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.76160899
48Selenocompound metabolism_Homo sapiens_hsa004500.75268494
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74290499
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73657650
51Arginine and proline metabolism_Homo sapiens_hsa003300.71116723
52HTLV-I infection_Homo sapiens_hsa051660.70955087
53Thyroid cancer_Homo sapiens_hsa052160.68319795
54Carbon metabolism_Homo sapiens_hsa012000.67541491
55Legionellosis_Homo sapiens_hsa051340.67363251
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66468133
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64165064
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61989098
59N-Glycan biosynthesis_Homo sapiens_hsa005100.61061300
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60693068
61Galactose metabolism_Homo sapiens_hsa000520.59431525
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58711966
63Steroid biosynthesis_Homo sapiens_hsa001000.58212635
64Oocyte meiosis_Homo sapiens_hsa041140.57426579
65Glutathione metabolism_Homo sapiens_hsa004800.55814410
66Apoptosis_Homo sapiens_hsa042100.54313496
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53226174
68Phenylalanine metabolism_Homo sapiens_hsa003600.52152477
69Shigellosis_Homo sapiens_hsa051310.51794613
70Vibrio cholerae infection_Homo sapiens_hsa051100.50097955
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50084702
72Fructose and mannose metabolism_Homo sapiens_hsa000510.49934612
73Measles_Homo sapiens_hsa051620.47831323
74Sulfur metabolism_Homo sapiens_hsa009200.46581427
75Fatty acid metabolism_Homo sapiens_hsa012120.45963020
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44832351
77Small cell lung cancer_Homo sapiens_hsa052220.43537527
78Alzheimers disease_Homo sapiens_hsa050100.43297323
79Bladder cancer_Homo sapiens_hsa052190.43088895
80Acute myeloid leukemia_Homo sapiens_hsa052210.40937639
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40298382
82Propanoate metabolism_Homo sapiens_hsa006400.39296787
83Notch signaling pathway_Homo sapiens_hsa043300.37635252
84Arginine biosynthesis_Homo sapiens_hsa002200.37314455
85Peroxisome_Homo sapiens_hsa041460.36889027
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36428538
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.35918929
88Tyrosine metabolism_Homo sapiens_hsa003500.33749364
89Hematopoietic cell lineage_Homo sapiens_hsa046400.33674643
90Hepatitis B_Homo sapiens_hsa051610.33509136
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32740920
92Alcoholism_Homo sapiens_hsa050340.30981056
93Chronic myeloid leukemia_Homo sapiens_hsa052200.30264021
94Colorectal cancer_Homo sapiens_hsa052100.30108307
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.29143189
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28815669
97Viral myocarditis_Homo sapiens_hsa054160.28807225
98Metabolic pathways_Homo sapiens_hsa011000.27013245
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25416643
100MicroRNAs in cancer_Homo sapiens_hsa052060.23421100
101Influenza A_Homo sapiens_hsa051640.23082078
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22749915
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21801991
104Basal cell carcinoma_Homo sapiens_hsa052170.21671758
105Leishmaniasis_Homo sapiens_hsa051400.21506453
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21189683
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20111102
108HIF-1 signaling pathway_Homo sapiens_hsa040660.19460880
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19173603
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.18945068
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16483401
112Other glycan degradation_Homo sapiens_hsa005110.15425686
113B cell receptor signaling pathway_Homo sapiens_hsa046620.15399255
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13016621
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.12712449
116Asthma_Homo sapiens_hsa053100.12525306
117Hedgehog signaling pathway_Homo sapiens_hsa043400.12285498
118Pathways in cancer_Homo sapiens_hsa052000.12222142
119Hippo signaling pathway_Homo sapiens_hsa043900.11945141
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11675896
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11614139
122Fatty acid degradation_Homo sapiens_hsa000710.10058513
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09911416
124Cardiac muscle contraction_Homo sapiens_hsa042600.09889601
125Lysine degradation_Homo sapiens_hsa003100.06235484
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06010411
127Synaptic vesicle cycle_Homo sapiens_hsa047210.03894871

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