LSM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.60270938
2viral transcription (GO:0019083)6.51012274
3translational termination (GO:0006415)6.29433778
4ribosomal small subunit assembly (GO:0000028)5.99804157
5maturation of SSU-rRNA (GO:0030490)5.69240024
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.63529449
7cotranslational protein targeting to membrane (GO:0006613)5.60332557
8protein targeting to ER (GO:0045047)5.53701018
9translational elongation (GO:0006414)5.37134282
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.26587198
11protein localization to endoplasmic reticulum (GO:0070972)5.23278619
12viral life cycle (GO:0019058)4.97560459
13cellular protein complex disassembly (GO:0043624)4.97350617
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.93117266
15ribosomal large subunit biogenesis (GO:0042273)4.91656642
16translational initiation (GO:0006413)4.90116624
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.79660835
18establishment of integrated proviral latency (GO:0075713)4.51589904
19DNA deamination (GO:0045006)4.44962877
20respiratory electron transport chain (GO:0022904)4.39486403
21proteasome assembly (GO:0043248)4.35906864
22electron transport chain (GO:0022900)4.30407498
23protein complex biogenesis (GO:0070271)4.29441993
24protein complex disassembly (GO:0043241)4.29282289
25translation (GO:0006412)4.25497554
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.23135076
27NADH dehydrogenase complex assembly (GO:0010257)4.23135076
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23135076
29mitochondrial respiratory chain complex assembly (GO:0033108)4.21229320
30ribonucleoprotein complex biogenesis (GO:0022613)4.18012278
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08610977
32transcription elongation from RNA polymerase III promoter (GO:0006385)4.08495240
33termination of RNA polymerase III transcription (GO:0006386)4.08495240
34macromolecular complex disassembly (GO:0032984)4.07453765
35kinetochore organization (GO:0051383)3.99586738
36telomere maintenance via semi-conservative replication (GO:0032201)3.98812240
37CENP-A containing nucleosome assembly (GO:0034080)3.95042588
38DNA strand elongation involved in DNA replication (GO:0006271)3.93607932
39ATP synthesis coupled proton transport (GO:0015986)3.92949215
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92949215
41kinetochore assembly (GO:0051382)3.89679587
42spliceosomal complex assembly (GO:0000245)3.85680053
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84627075
44chromatin remodeling at centromere (GO:0031055)3.83789118
45establishment of viral latency (GO:0019043)3.81970020
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.81253263
477-methylguanosine mRNA capping (GO:0006370)3.80924862
48rRNA processing (GO:0006364)3.78138996
49spliceosomal snRNP assembly (GO:0000387)3.77505877
50RNA capping (GO:0036260)3.76851258
517-methylguanosine RNA capping (GO:0009452)3.76851258
52DNA strand elongation (GO:0022616)3.75213713
53* nuclear-transcribed mRNA catabolic process (GO:0000956)3.74671446
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64846642
55rRNA metabolic process (GO:0016072)3.63038421
56protein targeting to membrane (GO:0006612)3.62103614
57telomere maintenance via recombination (GO:0000722)3.59888990
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.59887504
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.59635482
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58121410
61protein neddylation (GO:0045116)3.55467636
62* mRNA catabolic process (GO:0006402)3.55324466
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54901500
64negative regulation of ligase activity (GO:0051352)3.54901500
65cellular component biogenesis (GO:0044085)3.54320149
66formation of translation preinitiation complex (GO:0001731)3.52830060
67transcription-coupled nucleotide-excision repair (GO:0006283)3.51123878
68DNA double-strand break processing (GO:0000729)3.50048739
69* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48192688
70respiratory chain complex IV assembly (GO:0008535)3.47585425
71* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45072588
72DNA replication initiation (GO:0006270)3.42890370
73transcription elongation from RNA polymerase I promoter (GO:0006362)3.42570371
74protein localization to kinetochore (GO:0034501)3.41611661
75DNA replication checkpoint (GO:0000076)3.38847747
76DNA replication-independent nucleosome organization (GO:0034724)3.35949233
77DNA replication-independent nucleosome assembly (GO:0006336)3.35949233
78rRNA modification (GO:0000154)3.35138806
79termination of RNA polymerase I transcription (GO:0006363)3.34933559
80mitotic recombination (GO:0006312)3.34465627
81* RNA catabolic process (GO:0006401)3.32606713
82pseudouridine synthesis (GO:0001522)3.28323865
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28317172
84transcription from RNA polymerase I promoter (GO:0006360)3.27257617
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24566386
86regulation of mitotic spindle checkpoint (GO:1903504)3.24566386
87GTP biosynthetic process (GO:0006183)3.23972629
88mitotic metaphase plate congression (GO:0007080)3.23605925
89protein targeting to mitochondrion (GO:0006626)3.23152416
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22428268
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22428268
92DNA damage response, detection of DNA damage (GO:0042769)3.22168586
93metaphase plate congression (GO:0051310)3.21136219
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20855400
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20855400
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20855400
97cytochrome complex assembly (GO:0017004)3.20305133
98telomere maintenance via telomere lengthening (GO:0010833)3.18965561
99signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17637934
100signal transduction involved in DNA damage checkpoint (GO:0072422)3.17637934
101regulation of mitochondrial translation (GO:0070129)3.15231060
102signal transduction involved in cell cycle checkpoint (GO:0072395)3.14652208
103regulation of cellular amino acid metabolic process (GO:0006521)3.13595883
104nucleotide-excision repair, DNA gap filling (GO:0006297)3.13072224
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12363568
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12037672
107histone exchange (GO:0043486)3.08862585
108chaperone-mediated protein transport (GO:0072321)3.08856293
109tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07169737
110RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07169737
111cullin deneddylation (GO:0010388)3.06225914
112water-soluble vitamin biosynthetic process (GO:0042364)3.04907829
113oxidative phosphorylation (GO:0006119)3.04737085
114DNA catabolic process, exonucleolytic (GO:0000738)3.04405925
115replication fork processing (GO:0031297)3.03793988
116positive regulation of ligase activity (GO:0051351)3.03574340
117protein localization to mitochondrion (GO:0070585)3.03247431
118establishment of protein localization to mitochondrion (GO:0072655)3.02217085
119UTP biosynthetic process (GO:0006228)2.99818177
120ribosome biogenesis (GO:0042254)2.98516212
121negative regulation of DNA-dependent DNA replication (GO:2000104)2.97865019
122DNA ligation (GO:0006266)2.97313594
123histone mRNA metabolic process (GO:0008334)2.97202719
124peptidyl-histidine modification (GO:0018202)2.95884347
125ATP biosynthetic process (GO:0006754)2.95791206
126protein K6-linked ubiquitination (GO:0085020)2.94787282
127spindle checkpoint (GO:0031577)2.94067659
128transcription elongation from RNA polymerase II promoter (GO:0006368)2.93917772
129ribosome assembly (GO:0042255)2.92809000
130inner mitochondrial membrane organization (GO:0007007)2.92708660
131antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.92694305
132purine nucleobase biosynthetic process (GO:0009113)2.92438165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.78937520
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62919274
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.50126876
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.29257545
5* GABP_17652178_ChIP-ChIP_JURKAT_Human4.10653434
6* EST1_17652178_ChIP-ChIP_JURKAT_Human4.03289957
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47911453
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.45833906
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41070127
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39061657
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29529752
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.20659898
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15563724
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14856257
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14774392
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04337048
17MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02755428
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92846520
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90366413
20* FOXM1_23109430_ChIP-Seq_U2OS_Human2.84779224
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76840963
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76440980
23VDR_23849224_ChIP-Seq_CD4+_Human2.70158750
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69558305
25XRN2_22483619_ChIP-Seq_HELA_Human2.65302389
26DCP1A_22483619_ChIP-Seq_HELA_Human2.34398734
27ELK1_19687146_ChIP-ChIP_HELA_Human2.33121575
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31874265
29TTF2_22483619_ChIP-Seq_HELA_Human2.25804372
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23823655
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.20823351
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10881051
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04214967
34* GABP_19822575_ChIP-Seq_HepG2_Human1.88811493
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84454337
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83903914
37* SRF_21415370_ChIP-Seq_HL-1_Mouse1.82625970
38EWS_26573619_Chip-Seq_HEK293_Human1.82051624
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79291176
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.75334836
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74118137
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71676458
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70410367
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68734282
45FUS_26573619_Chip-Seq_HEK293_Human1.68434931
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67703426
47ZNF274_21170338_ChIP-Seq_K562_Hela1.64884042
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63062145
49VDR_22108803_ChIP-Seq_LS180_Human1.61565306
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57893911
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57862981
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57491152
53AR_21909140_ChIP-Seq_LNCAP_Human1.49058836
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47817053
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47628827
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.46124494
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.43962954
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.43793851
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43774831
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41210574
61* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40948139
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38418635
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37812606
64MYC_18940864_ChIP-ChIP_HL60_Human1.35413523
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.31273812
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29321764
67* NANOG_16153702_ChIP-ChIP_HESCs_Human1.27363092
68* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27259881
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24292274
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22600349
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.15631237
72IGF1R_20145208_ChIP-Seq_DFB_Human1.13928115
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13631327
74CIITA_25753668_ChIP-Seq_RAJI_Human1.13417938
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11466124
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11305068
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09518569
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08227800
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08084890
80TAF15_26573619_Chip-Seq_HEK293_Human1.07246447
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06979689
82* KDM5A_27292631_Chip-Seq_BREAST_Human1.03874142
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03609534
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00397453
85* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99440520
86IRF1_19129219_ChIP-ChIP_H3396_Human0.98700783
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97499637
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.97413706
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97350121
90P300_19829295_ChIP-Seq_ESCs_Human0.96945514
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95368939
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94989277
93* SPI1_23547873_ChIP-Seq_NB4_Human0.94697382
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93794852
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.93449474
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91549941
97* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90993558
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90093900
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90093900
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90093900
101KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89744647
102TP53_22573176_ChIP-Seq_HFKS_Human0.89149566
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83670945
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83256077
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82963268
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82659508
107* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81837271
108KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81332307
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.80577695
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79921906
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78875205
112TFEB_21752829_ChIP-Seq_HELA_Human0.77881895
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77754308
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77254180
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76766577
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75923526
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75676565
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75136223
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74301810
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73579952
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72953876
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72284669
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71440176
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70982671
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70915888
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70639682
127FOXA1_25329375_ChIP-Seq_VCAP_Human0.69721948
128FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69721948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.16139315
2MP0009379_abnormal_foot_pigmentation4.68455962
3MP0004957_abnormal_blastocyst_morpholog4.03026292
4MP0008057_abnormal_DNA_replication3.60486082
5MP0010094_abnormal_chromosome_stability3.56727506
6MP0003077_abnormal_cell_cycle3.44002161
7MP0003111_abnormal_nucleus_morphology3.35103412
8MP0008058_abnormal_DNA_repair2.89755672
9MP0008932_abnormal_embryonic_tissue2.81224303
10MP0003136_yellow_coat_color2.78911587
11MP0008007_abnormal_cellular_replicative2.34967640
12MP0009697_abnormal_copulation2.25720052
13MP0003718_maternal_effect2.20509955
14MP0006292_abnormal_olfactory_placode2.12339865
15MP0003786_premature_aging2.12132489
16MP0001986_abnormal_taste_sensitivity1.92336138
17MP0001529_abnormal_vocalization1.88106756
18MP0003806_abnormal_nucleotide_metabolis1.71735666
19MP0009333_abnormal_splenocyte_physiolog1.69896301
20MP0003186_abnormal_redox_activity1.61651394
21MP0003315_abnormal_perineum_morphology1.59666035
22MP0003123_paternal_imprinting1.58390752
23MP0004381_abnormal_hair_follicle1.56542582
24MP0000372_irregular_coat_pigmentation1.53468539
25MP0002938_white_spotting1.52609085
26MP0000350_abnormal_cell_proliferation1.48215253
27MP0002102_abnormal_ear_morphology1.48044800
28MP0001730_embryonic_growth_arrest1.47411134
29MP0002736_abnormal_nociception_after1.42629436
30MP0002132_abnormal_respiratory_system1.40920722
31MP0008877_abnormal_DNA_methylation1.40540414
32MP0004133_heterotaxia1.40107661
33MP0001188_hyperpigmentation1.38691474
34MP0005253_abnormal_eye_physiology1.37851774
35MP0000566_synostosis1.34432291
36MP0000631_abnormal_neuroendocrine_gland1.31254371
37MP0008789_abnormal_olfactory_epithelium1.30915958
38MP0002234_abnormal_pharynx_morphology1.29402089
39MP0001905_abnormal_dopamine_level1.24897416
40MP0002837_dystrophic_cardiac_calcinosis1.23792576
41MP0002396_abnormal_hematopoietic_system1.22974157
42MP0002163_abnormal_gland_morphology1.20748947
43MP0000313_abnormal_cell_death1.20340732
44MP0000490_abnormal_crypts_of1.19888301
45MP0003119_abnormal_digestive_system1.19028699
46MP0002638_abnormal_pupillary_reflex1.15361825
47MP0006035_abnormal_mitochondrial_morpho1.14060189
48MP0005084_abnormal_gallbladder_morpholo1.13516316
49MP0003880_abnormal_central_pattern1.12319035
50MP0002210_abnormal_sex_determination1.12135190
51MP0005409_darkened_coat_color1.11826810
52MP0006036_abnormal_mitochondrial_physio1.09336644
53MP0001697_abnormal_embryo_size1.08168426
54MP0003763_abnormal_thymus_physiology1.07373894
55MP0002095_abnormal_skin_pigmentation1.06913177
56MP0001727_abnormal_embryo_implantation1.06254413
57MP0004142_abnormal_muscle_tone1.05785916
58MP0003567_abnormal_fetal_cardiomyocyte1.05362566
59MP0002160_abnormal_reproductive_system1.04488638
60MP0003011_delayed_dark_adaptation1.03241637
61MP0001984_abnormal_olfaction1.03235846
62MP0002751_abnormal_autonomic_nervous1.03068169
63MP0005408_hypopigmentation1.02931505
64MP0001764_abnormal_homeostasis1.01563761
65MP0005551_abnormal_eye_electrophysiolog1.01477816
66MP0002233_abnormal_nose_morphology0.98959686
67MP0010030_abnormal_orbit_morphology0.98893391
68MP0002019_abnormal_tumor_incidence0.98512561
69MP0001145_abnormal_male_reproductive0.98189036
70MP0002080_prenatal_lethality0.97024295
71MP0002697_abnormal_eye_size0.96811932
72MP0002085_abnormal_embryonic_tissue0.96208261
73MP0003938_abnormal_ear_development0.95914869
74MP0004147_increased_porphyrin_level0.95007798
75MP0006072_abnormal_retinal_apoptosis0.94926565
76MP0005671_abnormal_response_to0.93703440
77MP0005391_vision/eye_phenotype0.93625314
78MP0002653_abnormal_ependyma_morphology0.93317819
79MP0008875_abnormal_xenobiotic_pharmacok0.92989794
80MP0001485_abnormal_pinna_reflex0.92775974
81MP0003941_abnormal_skin_development0.91773926
82MP0001293_anophthalmia0.91457423
83MP0008872_abnormal_physiological_respon0.90255033
84MP0005075_abnormal_melanosome_morpholog0.90251075
85MP0005389_reproductive_system_phenotype0.89815307
86MP0005174_abnormal_tail_pigmentation0.89458687
87MP0001672_abnormal_embryogenesis/_devel0.88934006
88MP0005380_embryogenesis_phenotype0.88934006
89MP0002277_abnormal_respiratory_mucosa0.88623372
90MP0002282_abnormal_trachea_morphology0.86199474
91MP0000703_abnormal_thymus_morphology0.85906333
92MP0003937_abnormal_limbs/digits/tail_de0.85655251
93MP0000647_abnormal_sebaceous_gland0.85059222
94MP0003195_calcinosis0.84439120
95MP0000653_abnormal_sex_gland0.84377792
96MP0004215_abnormal_myocardial_fiber0.83722795
97MP0002398_abnormal_bone_marrow0.83589639
98MP0001929_abnormal_gametogenesis0.83340108
99MP0005646_abnormal_pituitary_gland0.82595037
100MP0005367_renal/urinary_system_phenotyp0.81910055
101MP0000516_abnormal_urinary_system0.81910055
102MP0005195_abnormal_posterior_eye0.81617366
103MP0006276_abnormal_autonomic_nervous0.81362954
104MP0002722_abnormal_immune_system0.81293834
105MP0003890_abnormal_embryonic-extraembry0.80838784
106MP0001286_abnormal_eye_development0.80358950
107MP0002084_abnormal_developmental_patter0.77871582
108MP0001968_abnormal_touch/_nociception0.77187788
109MP0003121_genomic_imprinting0.77031722
110MP0002148_abnormal_hypersensitivity_rea0.76632101
111MP0001853_heart_inflammation0.76391792
112MP0003698_abnormal_male_reproductive0.75748778
113MP0000689_abnormal_spleen_morphology0.75478763
114MP0002090_abnormal_vision0.74074747
115MP0000049_abnormal_middle_ear0.73789858
116MP0000537_abnormal_urethra_morphology0.73301522
117MP0000358_abnormal_cell_content/0.72745259
118MP0002429_abnormal_blood_cell0.71625691
119MP0009785_altered_susceptibility_to0.70987791
120MP0005499_abnormal_olfactory_system0.70713155
121MP0005394_taste/olfaction_phenotype0.70713155
122MP0008995_early_reproductive_senescence0.70055097
123MP0009046_muscle_twitch0.68473150
124MP0001324_abnormal_eye_pigmentation0.68344405
125MP0003755_abnormal_palate_morphology0.68077454
126MP0003984_embryonic_growth_retardation0.67038119
127MP0000716_abnormal_immune_system0.66969661
128MP0000015_abnormal_ear_pigmentation0.65572323
129MP0001542_abnormal_bone_strength0.64827398
130MP0002088_abnormal_embryonic_growth/wei0.64386406
131MP0001119_abnormal_female_reproductive0.63180326
132MP0001919_abnormal_reproductive_system0.62578635
133MP0002111_abnormal_tail_morphology0.62349744
134MP0002420_abnormal_adaptive_immunity0.61153899
135MP0001819_abnormal_immune_cell0.59934088
136MP0000762_abnormal_tongue_morphology0.59063096

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.23865241
2Reticulocytopenia (HP:0001896)5.91816984
3Abnormal number of erythroid precursors (HP:0012131)5.57670638
4Macrocytic anemia (HP:0001972)4.50215288
5Acute necrotizing encephalopathy (HP:0006965)4.20972233
6Birth length less than 3rd percentile (HP:0003561)4.05958134
7Pallor (HP:0000980)4.01769206
8Mitochondrial inheritance (HP:0001427)3.76745858
9Increased hepatocellular lipid droplets (HP:0006565)3.67477700
10Aplastic anemia (HP:0001915)3.58968538
11Breast hypoplasia (HP:0003187)3.58952336
12Abnormal mitochondria in muscle tissue (HP:0008316)3.57281885
13Oral leukoplakia (HP:0002745)3.44432292
143-Methylglutaconic aciduria (HP:0003535)3.41279448
15Progressive macrocephaly (HP:0004481)3.35965684
16Increased CSF lactate (HP:0002490)3.23835783
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.21857893
18Acute encephalopathy (HP:0006846)3.21647301
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20711971
20Hepatocellular necrosis (HP:0001404)3.17071332
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16764143
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.15829534
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.15829534
24Lipid accumulation in hepatocytes (HP:0006561)3.08247227
25Renal Fanconi syndrome (HP:0001994)3.07289538
26Duplicated collecting system (HP:0000081)3.02165554
27Rough bone trabeculation (HP:0100670)2.96962764
28Carpal bone hypoplasia (HP:0001498)2.89761080
29Cerebral hypomyelination (HP:0006808)2.89173906
30Exertional dyspnea (HP:0002875)2.84359034
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.70744004
32Methylmalonic acidemia (HP:0002912)2.68689729
33Abnormality of the renal collecting system (HP:0004742)2.62716230
34Increased serum lactate (HP:0002151)2.60682642
35Colon cancer (HP:0003003)2.58462692
36Increased serum pyruvate (HP:0003542)2.58235536
37Abnormality of glycolysis (HP:0004366)2.58235536
38Type I transferrin isoform profile (HP:0003642)2.58216416
39Absent radius (HP:0003974)2.55852302
40Stenosis of the external auditory canal (HP:0000402)2.55542925
41Patellar aplasia (HP:0006443)2.55259914
42Pancreatic cysts (HP:0001737)2.54602493
43Hepatic necrosis (HP:0002605)2.53680567
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53575055
45Chromsome breakage (HP:0040012)2.49850175
46Pancreatic fibrosis (HP:0100732)2.47852214
47Absent thumb (HP:0009777)2.44201468
48Abnormality of midbrain morphology (HP:0002418)2.42940682
49Molar tooth sign on MRI (HP:0002419)2.42940682
50Abnormality of the preputium (HP:0100587)2.42894078
51Aplasia/Hypoplasia of the patella (HP:0006498)2.42530746
52Aplasia involving forearm bones (HP:0009822)2.40454125
53Absent forearm bone (HP:0003953)2.40454125
54Abnormality of the labia minora (HP:0012880)2.40296369
55Respiratory difficulties (HP:0002880)2.40228575
56True hermaphroditism (HP:0010459)2.39957449
57Meckel diverticulum (HP:0002245)2.39749659
58Abnormal trabecular bone morphology (HP:0100671)2.36877820
5911 pairs of ribs (HP:0000878)2.35431499
60Increased intramyocellular lipid droplets (HP:0012240)2.35006367
61Triphalangeal thumb (HP:0001199)2.34996153
62Premature graying of hair (HP:0002216)2.34569341
63Microretrognathia (HP:0000308)2.32623105
64Hyperglycinemia (HP:0002154)2.32296668
65Abnormality of the ileum (HP:0001549)2.32077889
66Congenital, generalized hypertrichosis (HP:0004540)2.29134738
67Horseshoe kidney (HP:0000085)2.26908028
68Leukodystrophy (HP:0002415)2.24677708
69Parakeratosis (HP:0001036)2.24600209
70Exercise intolerance (HP:0003546)2.23772916
71Abnormality of methionine metabolism (HP:0010901)2.21463512
72Septo-optic dysplasia (HP:0100842)2.20609131
73Abnormality of serum amino acid levels (HP:0003112)2.19062037
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17667195
75Respiratory failure (HP:0002878)2.16561996
76Abnormal lung lobation (HP:0002101)2.15466524
77Lethargy (HP:0001254)2.14961346
78Pancytopenia (HP:0001876)2.14253678
79Methylmalonic aciduria (HP:0012120)2.14070272
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09548559
81Abnormality of alanine metabolism (HP:0010916)2.09548559
82Hyperalaninemia (HP:0003348)2.09548559
83Abnormal number of incisors (HP:0011064)2.06270063
84Asplenia (HP:0001746)2.05140456
85Abnormality of the duodenum (HP:0002246)2.04716802
86Supernumerary spleens (HP:0009799)2.02957223
87Hypoplasia of the radius (HP:0002984)2.02392436
88Bone marrow hypocellularity (HP:0005528)2.01773788
89Pendular nystagmus (HP:0012043)2.01504232
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.01403082
91Nephronophthisis (HP:0000090)2.00520874
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00283905
93Duplication of thumb phalanx (HP:0009942)2.00248603
94Abnormality of chromosome stability (HP:0003220)1.98968551
95Abnormality of secondary sexual hair (HP:0009888)1.97925875
96Abnormality of the axillary hair (HP:0100134)1.97925875
97Medial flaring of the eyebrow (HP:0010747)1.97081093
98Cleft eyelid (HP:0000625)1.95424864
99Sloping forehead (HP:0000340)1.95218704
100Sparse eyelashes (HP:0000653)1.94394147
101Partial duplication of thumb phalanx (HP:0009944)1.94172892
102Depressed nasal ridge (HP:0000457)1.93959191
103Aplasia/hypoplasia of the uterus (HP:0008684)1.93342382
104Trismus (HP:0000211)1.93012244
105Optic disc pallor (HP:0000543)1.92871501
106Reduced antithrombin III activity (HP:0001976)1.91759528
107Hypoplasia of the pons (HP:0012110)1.90524681
108Cerebral edema (HP:0002181)1.88442984
109Cellular immunodeficiency (HP:0005374)1.87600296
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.86457428
111Lactic acidosis (HP:0003128)1.86274177
112Congenital ichthyosiform erythroderma (HP:0007431)1.86272808
113Abnormality of the anterior horn cell (HP:0006802)1.86176409
114Degeneration of anterior horn cells (HP:0002398)1.86176409
115Abnormality of the pons (HP:0007361)1.85364324
116Poor head control (HP:0002421)1.84886846
117Glycosuria (HP:0003076)1.84715243
118Abnormality of urine glucose concentration (HP:0011016)1.84715243
119Small intestinal stenosis (HP:0012848)1.84004992
120Duodenal stenosis (HP:0100867)1.84004992
121Secondary amenorrhea (HP:0000869)1.82750097
122Sclerocornea (HP:0000647)1.82014468
123Myelodysplasia (HP:0002863)1.81066797
124CNS demyelination (HP:0007305)1.80917474
125Ectopic kidney (HP:0000086)1.80760278
126Abnormality of renal resorption (HP:0011038)1.80507401
127Irregular epiphyses (HP:0010582)1.80424049
128Megaloblastic anemia (HP:0001889)1.79591009
129Abnormal protein glycosylation (HP:0012346)1.79464411
130Abnormal glycosylation (HP:0012345)1.79464411
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79464411
132Abnormal protein N-linked glycosylation (HP:0012347)1.79464411
133Selective tooth agenesis (HP:0001592)1.79311358
134Clubbing of toes (HP:0100760)1.78385419
135Aplasia/Hypoplasia involving the musculature (HP:0001460)1.74310054
136Increased muscle lipid content (HP:0009058)1.72238786
137X-linked dominant inheritance (HP:0001423)1.71903472
138Abnormality of the carotid arteries (HP:0005344)1.71413488
139Absent septum pellucidum (HP:0001331)1.69969279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.07844426
2WEE14.03013106
3NME24.00177842
4VRK23.93969635
5STK163.22606776
6EIF2AK13.06919316
7SRPK12.98712074
8VRK12.78379897
9CDC72.77918798
10PBK2.45520268
11PLK42.25026969
12MST42.19701351
13TESK22.16356312
14TLK12.14217017
15EIF2AK32.13004593
16WNK31.93417419
17NUAK11.84989207
18DYRK31.83897348
19MKNK11.81337861
20TRIM281.68352958
21ACVR1B1.68193968
22BRSK21.64313611
23TAF11.60062613
24PNCK1.58795011
25PLK11.49897933
26MAP4K21.39701999
27AURKB1.36256896
28LIMK11.35229341
29TTK1.33673782
30DYRK21.32493102
31AURKA1.30541655
32BRAF1.28457377
33NEK21.24546701
34PLK31.23450320
35NME11.22113453
36MKNK21.21084761
37TSSK61.19843327
38PIM21.18152920
39GRK11.17113810
40CDK71.16695052
41CCNB11.16313348
42RPS6KB21.11086336
43EIF2AK21.05759424
44IRAK41.04667462
45KDR0.99061098
46RPS6KA40.95885210
47ATR0.94820421
48FRK0.94639451
49ZAK0.94614367
50PASK0.93742459
51BCKDK0.92852155
52CHEK20.91990748
53RPS6KA50.91645535
54STK390.91195037
55MAP3K80.90113070
56CLK10.88179742
57CDK190.87020828
58PDK20.86829833
59LRRK20.84347227
60ERBB30.83801760
61PLK20.83274713
62CDK80.83035448
63BCR0.82805082
64BMPR1B0.81222125
65CSNK1G20.80704761
66BRSK10.78352497
67MAP3K40.78279318
68CSNK2A10.77800736
69CSNK1G30.77594091
70CSNK2A20.72556000
71MAP2K70.72049675
72ABL20.70915018
73TESK10.70084340
74STK38L0.69951195
75TEC0.69242002
76EPHA20.68255120
77INSRR0.68136170
78TGFBR10.65527660
79ADRBK20.65350455
80CHEK10.65236382
81MAP2K20.64707978
82PAK10.64270872
83UHMK10.64160419
84STK40.63059481
85ARAF0.59827771
86STK100.59798520
87NEK10.58775049
88IRAK30.58702932
89MAPKAPK50.57938673
90YES10.55024999
91STK30.55014949
92BLK0.53292930
93CDK30.53278731
94PRKCG0.48929959
95MUSK0.46943019
96OXSR10.46327772
97CASK0.45554237
98TNIK0.44811375
99ATM0.44809857
100MELK0.44785336
101EPHA40.44247874
102PAK40.43341796
103PRKCI0.42173021
104WNK40.42162558
105CSNK1G10.42110440
106CDK10.40229622
107ILK0.40041233
108PIM10.39746524
109SCYL20.38641893
110CSNK1E0.38123109
111CDK20.37895292
112CSNK1A1L0.36620110
113PINK10.34647175
114IKBKB0.34395605
115MAP3K120.33926568
116NEK60.33752907
117TXK0.33647715
118CSNK1A10.32315222
119GRK70.32298316
120MAP3K110.31130742
121CDK140.30701457
122BTK0.30678609
123LYN0.30627319
124CDK11A0.30625881
125PRKCE0.29627347
126MAPK130.28446940
127CDK40.28047840
128MINK10.27223305
129NLK0.27069311
130PKN10.24470280
131PRKACB0.24280996
132PRKDC0.23371100
133FGFR10.22830253
134OBSCN0.22651184
135ERBB40.21993916

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.74821455
2Proteasome_Homo sapiens_hsa030504.18360011
3RNA polymerase_Homo sapiens_hsa030203.91221935
4DNA replication_Homo sapiens_hsa030303.84501872
5Mismatch repair_Homo sapiens_hsa034303.30264692
6* Spliceosome_Homo sapiens_hsa030403.16326230
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03018504
8Homologous recombination_Homo sapiens_hsa034402.87300455
9Oxidative phosphorylation_Homo sapiens_hsa001902.76192510
10Pyrimidine metabolism_Homo sapiens_hsa002402.66076103
11Protein export_Homo sapiens_hsa030602.59651341
12Nucleotide excision repair_Homo sapiens_hsa034202.56486406
13Parkinsons disease_Homo sapiens_hsa050122.48008444
14RNA transport_Homo sapiens_hsa030132.25735268
15Base excision repair_Homo sapiens_hsa034102.25209821
16Basal transcription factors_Homo sapiens_hsa030222.01287663
17Huntingtons disease_Homo sapiens_hsa050162.00770934
18Fanconi anemia pathway_Homo sapiens_hsa034601.99868625
19Cell cycle_Homo sapiens_hsa041101.81878639
20Non-homologous end-joining_Homo sapiens_hsa034501.74890918
21* RNA degradation_Homo sapiens_hsa030181.69914041
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66500796
23Alzheimers disease_Homo sapiens_hsa050101.60343936
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56622565
25Purine metabolism_Homo sapiens_hsa002301.49910542
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45305770
27Propanoate metabolism_Homo sapiens_hsa006401.34716619
28One carbon pool by folate_Homo sapiens_hsa006701.33008713
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31191278
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27751395
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23706971
32p53 signaling pathway_Homo sapiens_hsa041151.11546674
33Pyruvate metabolism_Homo sapiens_hsa006201.11025094
34Systemic lupus erythematosus_Homo sapiens_hsa053221.02901819
35Epstein-Barr virus infection_Homo sapiens_hsa051691.02403083
36mRNA surveillance pathway_Homo sapiens_hsa030150.99109986
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98999645
38Folate biosynthesis_Homo sapiens_hsa007900.96570229
39Selenocompound metabolism_Homo sapiens_hsa004500.89567469
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88687654
41Glutathione metabolism_Homo sapiens_hsa004800.79764816
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74505823
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74170112
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74112696
45Sulfur metabolism_Homo sapiens_hsa009200.72355983
46Butanoate metabolism_Homo sapiens_hsa006500.71721330
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69833993
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66724514
49Primary immunodeficiency_Homo sapiens_hsa053400.65724171
50Cardiac muscle contraction_Homo sapiens_hsa042600.65237654
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64307177
52Chemical carcinogenesis_Homo sapiens_hsa052040.63278452
53Vitamin B6 metabolism_Homo sapiens_hsa007500.61970937
54Peroxisome_Homo sapiens_hsa041460.61835177
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60206211
56Arachidonic acid metabolism_Homo sapiens_hsa005900.59478337
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57943013
58Steroid biosynthesis_Homo sapiens_hsa001000.57236987
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55172671
60Tryptophan metabolism_Homo sapiens_hsa003800.54562971
61Graft-versus-host disease_Homo sapiens_hsa053320.53957608
62Caffeine metabolism_Homo sapiens_hsa002320.52899212
63Ether lipid metabolism_Homo sapiens_hsa005650.52351976
64Antigen processing and presentation_Homo sapiens_hsa046120.51564734
65Sulfur relay system_Homo sapiens_hsa041220.51509906
66Metabolic pathways_Homo sapiens_hsa011000.49887066
67Herpes simplex infection_Homo sapiens_hsa051680.49603409
68Oocyte meiosis_Homo sapiens_hsa041140.49004507
69Allograft rejection_Homo sapiens_hsa053300.48643348
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.46901031
71Vitamin digestion and absorption_Homo sapiens_hsa049770.46875543
72Retinol metabolism_Homo sapiens_hsa008300.46267517
73Viral carcinogenesis_Homo sapiens_hsa052030.45191244
74Alcoholism_Homo sapiens_hsa050340.43646077
75Collecting duct acid secretion_Homo sapiens_hsa049660.43574457
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43140794
77Autoimmune thyroid disease_Homo sapiens_hsa053200.42532027
78Fatty acid elongation_Homo sapiens_hsa000620.42447590
79Sphingolipid metabolism_Homo sapiens_hsa006000.41906820
80Asthma_Homo sapiens_hsa053100.41255115
81Carbon metabolism_Homo sapiens_hsa012000.41030880
82Nitrogen metabolism_Homo sapiens_hsa009100.40287540
83Pentose phosphate pathway_Homo sapiens_hsa000300.40105222
84Linoleic acid metabolism_Homo sapiens_hsa005910.39641110
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.39311850
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38657491
87Regulation of autophagy_Homo sapiens_hsa041400.38001320
88Nicotine addiction_Homo sapiens_hsa050330.37612339
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35564106
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.34915958
91beta-Alanine metabolism_Homo sapiens_hsa004100.34228617
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32709470
93Fatty acid degradation_Homo sapiens_hsa000710.32664041
94Biosynthesis of amino acids_Homo sapiens_hsa012300.32214824
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.32038426
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.31793506
97HTLV-I infection_Homo sapiens_hsa051660.30915674
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30658902
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29203757
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.27822588
101Hematopoietic cell lineage_Homo sapiens_hsa046400.27105298
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26233870
103Phototransduction_Homo sapiens_hsa047440.25423439
104Tyrosine metabolism_Homo sapiens_hsa003500.24696973
105N-Glycan biosynthesis_Homo sapiens_hsa005100.22228099
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21129541
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20707788
108Apoptosis_Homo sapiens_hsa042100.20205211
109Olfactory transduction_Homo sapiens_hsa047400.20069701
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.19266258
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19006547
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18747483
113Fatty acid metabolism_Homo sapiens_hsa012120.18578609
114Legionellosis_Homo sapiens_hsa051340.18035456
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17444599
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17423131
117Shigellosis_Homo sapiens_hsa051310.17272318
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16484915
119TGF-beta signaling pathway_Homo sapiens_hsa043500.15148308
120Arginine and proline metabolism_Homo sapiens_hsa003300.14726985
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14148450
122Measles_Homo sapiens_hsa051620.13295207
123Thyroid cancer_Homo sapiens_hsa052160.12573981
124Hedgehog signaling pathway_Homo sapiens_hsa043400.12431072
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12036781
126Basal cell carcinoma_Homo sapiens_hsa052170.12029193
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11385150
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11009084
129Vibrio cholerae infection_Homo sapiens_hsa051100.10513813
130Rheumatoid arthritis_Homo sapiens_hsa053230.09794814
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.07946534
132Pathways in cancer_Homo sapiens_hsa052000.07834994
133Phagosome_Homo sapiens_hsa041450.07089655
134Renin-angiotensin system_Homo sapiens_hsa046140.05251102
135MicroRNAs in cancer_Homo sapiens_hsa052060.04841345
136Hepatitis B_Homo sapiens_hsa051610.04278996
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03371309

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