LSM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.80049667
2viral transcription (GO:0019083)5.69114782
3ribosomal small subunit biogenesis (GO:0042274)5.59882689
4translational termination (GO:0006415)5.50616832
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.37413622
6cotranslational protein targeting to membrane (GO:0006613)5.30527519
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29258929
8protein targeting to ER (GO:0045047)5.20621319
9ATP synthesis coupled proton transport (GO:0015986)5.06586929
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.06586929
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.94238512
12protein localization to endoplasmic reticulum (GO:0070972)4.94087330
13maturation of SSU-rRNA (GO:0030490)4.72933919
14translational elongation (GO:0006414)4.70069594
15cellular protein complex disassembly (GO:0043624)4.43359229
16ribosomal large subunit biogenesis (GO:0042273)4.40806346
17DNA deamination (GO:0045006)4.36099798
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.35212803
19viral life cycle (GO:0019058)4.33722407
20proteasome assembly (GO:0043248)4.30285835
21establishment of integrated proviral latency (GO:0075713)4.25147727
22telomere maintenance via semi-conservative replication (GO:0032201)4.24816062
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.24708395
24translational initiation (GO:0006413)4.17350358
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.16102053
26transcription elongation from RNA polymerase III promoter (GO:0006385)4.15238702
27termination of RNA polymerase III transcription (GO:0006386)4.15238702
28translation (GO:0006412)4.08492990
29respiratory electron transport chain (GO:0022904)3.90289331
30DNA strand elongation involved in DNA replication (GO:0006271)3.88188642
31protein neddylation (GO:0045116)3.83488831
32protein complex disassembly (GO:0043241)3.83240714
33rRNA modification (GO:0000154)3.81050444
34electron transport chain (GO:0022900)3.81023616
35protein complex biogenesis (GO:0070271)3.78422180
36chaperone-mediated protein transport (GO:0072321)3.77701170
37CENP-A containing nucleosome assembly (GO:0034080)3.76086204
38histone exchange (GO:0043486)3.74230538
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74067364
40respiratory chain complex IV assembly (GO:0008535)3.72589165
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71970812
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.71970812
43telomere maintenance via recombination (GO:0000722)3.69775392
44DNA strand elongation (GO:0022616)3.69462431
45macromolecular complex disassembly (GO:0032984)3.67379046
467-methylguanosine mRNA capping (GO:0006370)3.66217756
47chromatin remodeling at centromere (GO:0031055)3.64918042
48establishment of viral latency (GO:0019043)3.64752832
49transcription-coupled nucleotide-excision repair (GO:0006283)3.63442423
50RNA capping (GO:0036260)3.62787137
517-methylguanosine RNA capping (GO:0009452)3.62787137
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62378198
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.62378198
54NADH dehydrogenase complex assembly (GO:0010257)3.62378198
55kinetochore organization (GO:0051383)3.61956208
56kinetochore assembly (GO:0051382)3.61082177
57cullin deneddylation (GO:0010388)3.60952061
58inner mitochondrial membrane organization (GO:0007007)3.59657847
59cytochrome complex assembly (GO:0017004)3.58264857
60mitotic recombination (GO:0006312)3.56882442
61GTP biosynthetic process (GO:0006183)3.54052872
62* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52387823
63* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51897030
64spliceosomal complex assembly (GO:0000245)3.50291936
65mitochondrial respiratory chain complex assembly (GO:0033108)3.47933430
66protein deneddylation (GO:0000338)3.47428726
67ribonucleoprotein complex biogenesis (GO:0022613)3.47159392
68spliceosomal snRNP assembly (GO:0000387)3.47124632
69viral mRNA export from host cell nucleus (GO:0046784)3.46808222
70protein targeting to mitochondrion (GO:0006626)3.45693355
71ATP biosynthetic process (GO:0006754)3.44636853
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44481398
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43396582
74negative regulation of ligase activity (GO:0051352)3.42911569
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42911569
76regulation of mitochondrial translation (GO:0070129)3.41879100
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40049712
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.39711827
79telomere maintenance via telomere lengthening (GO:0010833)3.33997892
80purine nucleoside triphosphate biosynthetic process (GO:0009145)3.33638209
81protein targeting to membrane (GO:0006612)3.33489601
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30135854
83cellular component biogenesis (GO:0044085)3.30104285
84protein localization to mitochondrion (GO:0070585)3.29957490
85regulation of cellular amino acid metabolic process (GO:0006521)3.28753704
86* rRNA processing (GO:0006364)3.28128926
87* nuclear-transcribed mRNA catabolic process (GO:0000956)3.28003412
88establishment of protein localization to mitochondrion (GO:0072655)3.27361746
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26443270
90DNA damage response, detection of DNA damage (GO:0042769)3.25479279
91purine nucleobase biosynthetic process (GO:0009113)3.22865595
92protein-cofactor linkage (GO:0018065)3.22854831
93guanosine-containing compound biosynthetic process (GO:1901070)3.22585107
94intracellular protein transmembrane import (GO:0044743)3.21872104
95histone mRNA metabolic process (GO:0008334)3.21243457
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.20668947
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.20668947
98hydrogen ion transmembrane transport (GO:1902600)3.20320648
99establishment of protein localization to mitochondrial membrane (GO:0090151)3.19869018
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19419656
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19419656
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19419656
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18882987
104DNA double-strand break processing (GO:0000729)3.18442174
105peptidyl-histidine modification (GO:0018202)3.18163471
106oxidative phosphorylation (GO:0006119)3.17575190
107DNA ligation (GO:0006266)3.15579797
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14683316
109regulation of mitotic spindle checkpoint (GO:1903504)3.14683316
110* rRNA metabolic process (GO:0016072)3.13889823
111deoxyribonucleotide biosynthetic process (GO:0009263)3.13571190
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13565186
113water-soluble vitamin biosynthetic process (GO:0042364)3.12483223
114* mRNA catabolic process (GO:0006402)3.12478927
115UTP biosynthetic process (GO:0006228)3.12358026
116DNA replication initiation (GO:0006270)3.11213057
117DNA replication checkpoint (GO:0000076)3.11130822
118transcription elongation from RNA polymerase I promoter (GO:0006362)3.10931471
119signal transduction involved in DNA damage checkpoint (GO:0072422)3.10235427
120signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10235427
121signal transduction involved in cell cycle checkpoint (GO:0072395)3.08121664
122rRNA methylation (GO:0031167)3.06696174
123DNA replication-independent nucleosome organization (GO:0034724)3.02058012
124DNA replication-independent nucleosome assembly (GO:0006336)3.02058012
125pseudouridine synthesis (GO:0001522)3.00704247
126termination of RNA polymerase I transcription (GO:0006363)2.99120627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.38510190
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.96720937
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31629957
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.16379634
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.12010247
6* MYC_18555785_ChIP-Seq_MESCs_Mouse4.09776943
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.70725714
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.62262783
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.39230052
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25821708
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.19388231
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.16527715
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14094666
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11008191
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06126576
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05407173
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91339692
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90510827
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81119253
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79948330
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65536659
22VDR_23849224_ChIP-Seq_CD4+_Human2.62621328
23* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59876167
24XRN2_22483619_ChIP-Seq_HELA_Human2.39374979
25DCP1A_22483619_ChIP-Seq_HELA_Human2.34048356
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.33043673
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30650693
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.30022175
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21479230
30TTF2_22483619_ChIP-Seq_HELA_Human2.19548739
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17656832
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.15870206
33ELK1_19687146_ChIP-ChIP_HELA_Human2.15489353
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.15310829
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14219883
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03936224
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01672138
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87867799
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.85768509
40GABP_19822575_ChIP-Seq_HepG2_Human1.85702060
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82970011
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79194113
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72290992
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69862154
45MYC_18940864_ChIP-ChIP_HL60_Human1.55782495
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51595820
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50003308
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47912278
49ZNF274_21170338_ChIP-Seq_K562_Hela1.47885444
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46520386
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45483799
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45378636
53IRF1_19129219_ChIP-ChIP_H3396_Human1.43055766
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40659262
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.39760339
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32742249
57* E2F1_21310950_ChIP-Seq_MCF-7_Human1.31838250
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.31551662
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31284620
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28248074
61* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22811015
62AR_21909140_ChIP-Seq_LNCAP_Human1.19671255
63CIITA_25753668_ChIP-Seq_RAJI_Human1.16623190
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15450935
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14559946
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14475015
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12519978
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12023885
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.09637403
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07172183
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06240147
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03358515
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03002144
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01744192
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01354899
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01251704
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00950744
78IGF1R_20145208_ChIP-Seq_DFB_Human0.98980000
79SALL1_21062744_ChIP-ChIP_HESCs_Human0.96352957
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95241306
81TP53_22573176_ChIP-Seq_HFKS_Human0.93218118
82RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93052433
83KDM5A_27292631_Chip-Seq_BREAST_Human0.93047457
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92658169
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90820946
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90518820
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88528272
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87445405
89P300_19829295_ChIP-Seq_ESCs_Human0.86961230
90* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86374517
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.85512881
92EWS_26573619_Chip-Seq_HEK293_Human0.85409035
93* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85122104
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84727932
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.83964933
96TAF15_26573619_Chip-Seq_HEK293_Human0.82813867
97FUS_26573619_Chip-Seq_HEK293_Human0.82454321
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.81441220
99CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81175170
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80680208
101* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76331028
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74290739
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74207570
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73772815
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73049483
106FOXA1_25329375_ChIP-Seq_VCAP_Human0.73049483
107BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72454563
108NANOG_19829295_ChIP-Seq_ESCs_Human0.71178303
109SOX2_19829295_ChIP-Seq_ESCs_Human0.71178303
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.70969801
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69676765
112SPI1_23547873_ChIP-Seq_NB4_Human0.68379394
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.66865420
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.61176015
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.60763568
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.59309811
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.57689710
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.57406223
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.57314494
120VDR_22108803_ChIP-Seq_LS180_Human0.56191657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.55362943
2MP0003693_abnormal_embryo_hatching3.96677779
3MP0010094_abnormal_chromosome_stability3.17877515
4MP0001529_abnormal_vocalization3.15930911
5MP0008058_abnormal_DNA_repair2.91092554
6MP0003806_abnormal_nucleotide_metabolis2.89437958
7MP0004957_abnormal_blastocyst_morpholog2.89288838
8MP0006292_abnormal_olfactory_placode2.88278873
9MP0003077_abnormal_cell_cycle2.71084905
10MP0003136_yellow_coat_color2.65145337
11MP0008057_abnormal_DNA_replication2.62577402
12MP0003111_abnormal_nucleus_morphology2.61769907
13MP0002163_abnormal_gland_morphology2.51335857
14MP0008932_abnormal_embryonic_tissue2.42971808
15MP0002638_abnormal_pupillary_reflex2.38108592
16MP0001188_hyperpigmentation2.37331712
17MP0002102_abnormal_ear_morphology2.26659588
18MP0001905_abnormal_dopamine_level2.09210990
19MP0005084_abnormal_gallbladder_morpholo2.07666605
20MP0001986_abnormal_taste_sensitivity2.04831104
21MP0008007_abnormal_cellular_replicative2.03568881
22MP0000372_irregular_coat_pigmentation1.99848998
23MP0000566_synostosis1.88825839
24MP0005409_darkened_coat_color1.84030561
25MP0002938_white_spotting1.82672195
26MP0005379_endocrine/exocrine_gland_phen1.82160767
27MP0008877_abnormal_DNA_methylation1.82002865
28MP0003786_premature_aging1.77664232
29MP0002132_abnormal_respiratory_system1.56513270
30MP0006276_abnormal_autonomic_nervous1.56286252
31MP0005423_abnormal_somatic_nervous1.53093562
32MP0002751_abnormal_autonomic_nervous1.50757582
33MP0005171_absent_coat_pigmentation1.50402757
34MP0006036_abnormal_mitochondrial_physio1.48752605
35MP0003718_maternal_effect1.45576548
36MP0003567_abnormal_fetal_cardiomyocyte1.42935595
37MP0009697_abnormal_copulation1.41662549
38MP0003123_paternal_imprinting1.41534206
39MP0005174_abnormal_tail_pigmentation1.40685245
40MP0003195_calcinosis1.40394902
41MP0002837_dystrophic_cardiac_calcinosis1.40125056
42MP0003122_maternal_imprinting1.39383611
43MP0003121_genomic_imprinting1.38795566
44MP0006072_abnormal_retinal_apoptosis1.36446173
45MP0005408_hypopigmentation1.34085655
46MP0004133_heterotaxia1.33590885
47MP0003941_abnormal_skin_development1.32382378
48MP0004142_abnormal_muscle_tone1.31004236
49MP0003011_delayed_dark_adaptation1.29706758
50MP0002277_abnormal_respiratory_mucosa1.27234801
51MP0003186_abnormal_redox_activity1.25359825
52MP0003880_abnormal_central_pattern1.24593669
53MP0001984_abnormal_olfaction1.18098671
54MP0002095_abnormal_skin_pigmentation1.16985934
55MP0005075_abnormal_melanosome_morpholog1.16451186
56MP0008872_abnormal_physiological_respon1.16393675
57MP0000015_abnormal_ear_pigmentation1.15197164
58MP0002396_abnormal_hematopoietic_system1.11750905
59MP0000631_abnormal_neuroendocrine_gland1.11444287
60MP0008789_abnormal_olfactory_epithelium1.10115717
61MP0003315_abnormal_perineum_morphology1.09611865
62MP0010030_abnormal_orbit_morphology1.08776600
63MP0004381_abnormal_hair_follicle1.08473541
64MP0000049_abnormal_middle_ear1.08059692
65MP0001485_abnormal_pinna_reflex1.06431220
66MP0003890_abnormal_embryonic-extraembry1.03784060
67MP0005645_abnormal_hypothalamus_physiol1.01720784
68MP0006035_abnormal_mitochondrial_morpho1.00410148
69MP0005377_hearing/vestibular/ear_phenot1.00018904
70MP0003878_abnormal_ear_physiology1.00018904
71MP0002090_abnormal_vision0.96342410
72MP0008875_abnormal_xenobiotic_pharmacok0.95893647
73MP0002160_abnormal_reproductive_system0.94699462
74MP0002233_abnormal_nose_morphology0.94612187
75MP0004147_increased_porphyrin_level0.91620876
76MP0003763_abnormal_thymus_physiology0.91421532
77MP0001764_abnormal_homeostasis0.91243580
78MP0008995_early_reproductive_senescence0.90741468
79MP0002210_abnormal_sex_determination0.90302957
80MP0000313_abnormal_cell_death0.89419385
81MP0003938_abnormal_ear_development0.88892302
82MP0010386_abnormal_urinary_bladder0.87982351
83MP0002234_abnormal_pharynx_morphology0.85078761
84MP0005253_abnormal_eye_physiology0.83548120
85MP0000350_abnormal_cell_proliferation0.82456786
86MP0001119_abnormal_female_reproductive0.80405555
87MP0001919_abnormal_reproductive_system0.78651492
88MP0001186_pigmentation_phenotype0.77616924
89MP0005391_vision/eye_phenotype0.76834634
90MP0002653_abnormal_ependyma_morphology0.75171175
91MP0003119_abnormal_digestive_system0.74589028
92MP0000490_abnormal_crypts_of0.74549796
93MP0000026_abnormal_inner_ear0.73439728
94MP0005389_reproductive_system_phenotype0.73030670
95MP0002736_abnormal_nociception_after0.72987502
96MP0001697_abnormal_embryo_size0.72038235
97MP0002697_abnormal_eye_size0.71888128
98MP0002928_abnormal_bile_duct0.71371726
99MP0005195_abnormal_posterior_eye0.71304267
100MP0009333_abnormal_splenocyte_physiolog0.70768258
101MP0003787_abnormal_imprinting0.70121292
102MP0000613_abnormal_salivary_gland0.69642032
103MP0005671_abnormal_response_to0.69092837
104MP0001730_embryonic_growth_arrest0.68856950
105MP0004742_abnormal_vestibular_system0.68241798
106MP0001145_abnormal_male_reproductive0.67267310
107MP0003698_abnormal_male_reproductive0.67068235
108MP0001929_abnormal_gametogenesis0.66376406
109MP0001293_anophthalmia0.64032311
110MP0004145_abnormal_muscle_electrophysio0.63721505
111MP0000653_abnormal_sex_gland0.63523949
112MP0002085_abnormal_embryonic_tissue0.63060328
113MP0001968_abnormal_touch/_nociception0.61804778
114MP0005499_abnormal_olfactory_system0.60884690
115MP0005394_taste/olfaction_phenotype0.60884690
116MP0001286_abnormal_eye_development0.60742215
117MP0001727_abnormal_embryo_implantation0.60361187
118MP0003937_abnormal_limbs/digits/tail_de0.59870858
119MP0000358_abnormal_cell_content/0.58038038
120MP0002249_abnormal_larynx_morphology0.57704301
121MP0005646_abnormal_pituitary_gland0.56075833
122MP0001963_abnormal_hearing_physiology0.54808300
123MP0002177_abnormal_outer_ear0.53969343
124MP0000703_abnormal_thymus_morphology0.53601351
125MP0002752_abnormal_somatic_nervous0.53595054
126MP0000778_abnormal_nervous_system0.53404550
127MP0002019_abnormal_tumor_incidence0.53058401
128MP0002734_abnormal_mechanical_nocicepti0.52820873
129MP0005551_abnormal_eye_electrophysiolog0.52581415

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.27634202
2Mitochondrial inheritance (HP:0001427)4.90491640
3Abnormality of cells of the erythroid lineage (HP:0012130)4.84988725
4Abnormal mitochondria in muscle tissue (HP:0008316)4.77298300
5Reticulocytopenia (HP:0001896)4.76257515
6Abnormal number of erythroid precursors (HP:0012131)4.55915401
7Increased hepatocellular lipid droplets (HP:0006565)4.50503245
8Progressive macrocephaly (HP:0004481)4.28848338
9Increased CSF lactate (HP:0002490)4.22148650
10Hepatocellular necrosis (HP:0001404)4.19540140
11Acute encephalopathy (HP:0006846)3.99819116
12Lipid accumulation in hepatocytes (HP:0006561)3.89350749
13Renal Fanconi syndrome (HP:0001994)3.68923157
143-Methylglutaconic aciduria (HP:0003535)3.67818898
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.57293988
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53673659
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53673659
18Macrocytic anemia (HP:0001972)3.53583744
19Hepatic necrosis (HP:0002605)3.52176544
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.42938588
21Aplastic anemia (HP:0001915)3.42056416
22Pallor (HP:0000980)3.29526595
23Exertional dyspnea (HP:0002875)3.21482365
24Increased serum lactate (HP:0002151)3.04366677
25Exercise intolerance (HP:0003546)2.95737732
26Increased intramyocellular lipid droplets (HP:0012240)2.93892358
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90971586
28Congenital, generalized hypertrichosis (HP:0004540)2.79166905
29Optic disc pallor (HP:0000543)2.72443842
30Birth length less than 3rd percentile (HP:0003561)2.69046539
31Type I transferrin isoform profile (HP:0003642)2.68107228
32Leukodystrophy (HP:0002415)2.67018472
33Oral leukoplakia (HP:0002745)2.65658137
34Respiratory difficulties (HP:0002880)2.65556003
35Hypothermia (HP:0002045)2.63516593
36Methylmalonic acidemia (HP:0002912)2.63420138
37Respiratory failure (HP:0002878)2.62596732
38Abnormality of renal resorption (HP:0011038)2.48508114
39Abnormality of the labia minora (HP:0012880)2.48398100
40Lactic acidosis (HP:0003128)2.46774128
41Abnormality of glycolysis (HP:0004366)2.40815864
42Increased serum pyruvate (HP:0003542)2.40815864
4311 pairs of ribs (HP:0000878)2.40605988
44Chromsome breakage (HP:0040012)2.38992244
45Cerebral edema (HP:0002181)2.33009902
46Abnormality of midbrain morphology (HP:0002418)2.29072326
47Molar tooth sign on MRI (HP:0002419)2.29072326
48True hermaphroditism (HP:0010459)2.28769485
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28176037
50Methylmalonic aciduria (HP:0012120)2.26491682
51Cerebral hypomyelination (HP:0006808)2.25728757
52Lethargy (HP:0001254)2.25710552
53Microvesicular hepatic steatosis (HP:0001414)2.25030346
54Abnormality of the anterior horn cell (HP:0006802)2.24864063
55Degeneration of anterior horn cells (HP:0002398)2.24864063
56Triphalangeal thumb (HP:0001199)2.22586712
57Breast hypoplasia (HP:0003187)2.22475502
58Abnormality of methionine metabolism (HP:0010901)2.21812543
59Increased muscle lipid content (HP:0009058)2.21364366
60Premature graying of hair (HP:0002216)2.21127264
61Abnormality of the preputium (HP:0100587)2.20214319
62Hyperglycinemia (HP:0002154)2.19900016
63Abnormal number of incisors (HP:0011064)2.18622768
64Abnormal lung lobation (HP:0002101)2.13051046
65Colon cancer (HP:0003003)2.08270118
66Meckel diverticulum (HP:0002245)2.06219020
67Pancreatic cysts (HP:0001737)2.06099638
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04958597
69Cleft eyelid (HP:0000625)2.03519581
70Medial flaring of the eyebrow (HP:0010747)2.00590714
71Nephronophthisis (HP:0000090)2.00198659
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00100230
73Abnormality of serum amino acid levels (HP:0003112)1.99210979
74Glycosuria (HP:0003076)1.99107946
75Abnormality of urine glucose concentration (HP:0011016)1.99107946
76Duplicated collecting system (HP:0000081)1.99006440
77Abnormality of the ileum (HP:0001549)1.98853074
78Severe visual impairment (HP:0001141)1.97831085
79Abnormality of secondary sexual hair (HP:0009888)1.97478168
80Abnormality of the axillary hair (HP:0100134)1.97478168
81Pancreatic fibrosis (HP:0100732)1.96777511
82Aplasia/hypoplasia of the uterus (HP:0008684)1.94835437
83Absent thumb (HP:0009777)1.93811637
84Rough bone trabeculation (HP:0100670)1.93135880
85Megaloblastic anemia (HP:0001889)1.92910241
86X-linked dominant inheritance (HP:0001423)1.90134194
87Abnormal protein glycosylation (HP:0012346)1.89487625
88Abnormal glycosylation (HP:0012345)1.89487625
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89487625
90Abnormal protein N-linked glycosylation (HP:0012347)1.89487625
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.88460259
92CNS demyelination (HP:0007305)1.87920340
93Pendular nystagmus (HP:0012043)1.87909043
94Supernumerary spleens (HP:0009799)1.87747001
95Horseshoe kidney (HP:0000085)1.87304979
96Abnormality of chromosome stability (HP:0003220)1.84519744
97Hyperphosphaturia (HP:0003109)1.83183110
98Pancytopenia (HP:0001876)1.83000788
99Abnormality of the renal collecting system (HP:0004742)1.82187656
100Septo-optic dysplasia (HP:0100842)1.81566266
101Asplenia (HP:0001746)1.78781822
102Stenosis of the external auditory canal (HP:0000402)1.78002296
103Abnormality of alanine metabolism (HP:0010916)1.77137643
104Hyperalaninemia (HP:0003348)1.77137643
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77137643
106Hypoplasia of the pons (HP:0012110)1.76968891
107Depressed nasal ridge (HP:0000457)1.76099729
108Absent septum pellucidum (HP:0001331)1.75596978
109Carpal bone hypoplasia (HP:0001498)1.75267594
110Patellar aplasia (HP:0006443)1.74975219
111Nephrogenic diabetes insipidus (HP:0009806)1.73082683
112Duodenal stenosis (HP:0100867)1.72032557
113Small intestinal stenosis (HP:0012848)1.72032557
114Abnormality of the pons (HP:0007361)1.70906952
115IgM deficiency (HP:0002850)1.70779185
116Emotional lability (HP:0000712)1.70005716
117Duplication of thumb phalanx (HP:0009942)1.69998976
118Parakeratosis (HP:0001036)1.69328587
119Abnormality of the duodenum (HP:0002246)1.68626909
120Generalized aminoaciduria (HP:0002909)1.67670289
121Bone marrow hypocellularity (HP:0005528)1.67116820
122Hypoplasia of the radius (HP:0002984)1.65493656
123Type 2 muscle fiber atrophy (HP:0003554)1.65471936
124Congenital primary aphakia (HP:0007707)1.65359211
125Sclerocornea (HP:0000647)1.65295734
126Absent radius (HP:0003974)1.64905202
127Homocystinuria (HP:0002156)1.64112516
128Abnormality of homocysteine metabolism (HP:0010919)1.64112516
129Abnormality of the septum pellucidum (HP:0007375)1.63958853
130Bilateral microphthalmos (HP:0007633)1.63451689
131Cellular immunodeficiency (HP:0005374)1.62608742
132Abnormal hair whorl (HP:0010721)1.62148299
133Optic nerve coloboma (HP:0000588)1.61911894
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61708456
135Aplasia/Hypoplasia of the patella (HP:0006498)1.61432113
136Preaxial hand polydactyly (HP:0001177)1.60567236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.68328684
2VRK24.57849099
3STK163.90487934
4EIF2AK13.15496730
5WEE12.99658050
6SRPK12.95272143
7VRK12.86907798
8TLK12.83882269
9NME22.60891759
10NUAK12.34216764
11EIF2AK32.33703494
12PBK2.28250322
13CDC72.25510126
14MKNK12.12126009
15TRIM282.07162103
16NEK12.07155362
17ACVR1B1.78210931
18TAF11.70953223
19NME11.68343097
20CASK1.67441455
21TESK21.67170622
22BMPR1B1.62068450
23MKNK21.59455746
24PLK41.58775216
25BRSK21.56573898
26MST41.52538367
27CDK81.52357599
28TNIK1.47497772
29CDK191.38623092
30MUSK1.35914186
31CCNB11.35330938
32MAP4K21.33974151
33PASK1.33641256
34PIM21.29961804
35PLK31.26568886
36BCKDK1.26181648
37PLK11.25911705
38DYRK21.25092700
39EIF2AK21.22067900
40LIMK11.17932602
41BRAF1.15257536
42AURKB1.15120853
43TSSK61.14430946
44DYRK31.14263946
45UHMK11.10509392
46AURKA1.09505043
47BRSK11.08759575
48SIK31.07421369
49ADRBK21.05487125
50MAP3K121.03225425
51ZAK0.96855160
52IRAK40.96765830
53CDK70.95470985
54ARAF0.94635714
55TTK0.92497880
56ATR0.92268911
57MAPKAPK50.90348562
58BCR0.88666212
59PDK20.87121348
60CLK10.85780533
61MAPK130.80753727
62RPS6KA50.80292678
63CHEK20.79335014
64MAP3K40.78695717
65INSRR0.78456726
66CSNK1G30.76411234
67KDR0.76115371
68CSNK2A10.75951304
69YES10.75782193
70NEK20.75446863
71STK30.73795841
72GRK70.73293792
73CSNK2A20.68727235
74WNK30.68417615
75FRK0.65374029
76TEC0.65257545
77BLK0.63776599
78CSNK1G20.63726077
79TXK0.60968524
80RPS6KA40.59624647
81PLK20.58533450
82MYLK0.58021037
83WNK40.57893495
84STK240.55951376
85PNCK0.51706567
86PIK3CG0.50235216
87TIE10.49093296
88TESK10.49077066
89NEK60.48904504
90CHEK10.47780971
91ILK0.47633784
92STK390.46690425
93LYN0.46479052
94PRKCG0.46360738
95TGFBR10.46119234
96OXSR10.44911463
97STK38L0.44563992
98ALK0.44321979
99ADRBK10.41292114
100CDK30.41201939
101PAK10.40656910
102FGFR10.39669254
103ATM0.39625328
104MAP2K70.38965129
105BTK0.38661655
106STK40.38412081
107RPS6KB20.37386189
108CDK11A0.37313855
109IRAK20.37045842
110NLK0.36657635
111CSNK1G10.35510207
112CDK10.35293611
113CSNK1A1L0.34924378
114CSNK1E0.34781982
115DAPK10.34666644
116OBSCN0.34644294
117DAPK30.34336595
118GRK10.33428408
119BMPR20.33238684
120CSNK1A10.33236045
121CAMK2B0.33041695
122ERBB30.32929627
123CDK180.32557111
124ABL20.32448294
125CDK140.30786185
126IRAK30.30366699
127CDK150.30123612
128PIM10.28947861
129KIT0.28702288
130FES0.27952163
131PRKCE0.25945923
132PRKACA0.20685987
133PRKDC0.20337318
134EPHB20.19337589

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.19088179
2Proteasome_Homo sapiens_hsa030504.05736764
3DNA replication_Homo sapiens_hsa030303.76549118
4RNA polymerase_Homo sapiens_hsa030203.71511660
5Oxidative phosphorylation_Homo sapiens_hsa001903.64567915
6Protein export_Homo sapiens_hsa030603.53946727
7Mismatch repair_Homo sapiens_hsa034303.44983073
8Parkinsons disease_Homo sapiens_hsa050123.30679550
9Homologous recombination_Homo sapiens_hsa034403.00571738
10* Spliceosome_Homo sapiens_hsa030402.82870600
11Nucleotide excision repair_Homo sapiens_hsa034202.62594445
12Huntingtons disease_Homo sapiens_hsa050162.49998642
13Pyrimidine metabolism_Homo sapiens_hsa002402.49620633
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36653155
15Alzheimers disease_Homo sapiens_hsa050102.27455015
16Base excision repair_Homo sapiens_hsa034102.25337482
17Fanconi anemia pathway_Homo sapiens_hsa034602.01015074
18Non-homologous end-joining_Homo sapiens_hsa034501.95144679
19Basal transcription factors_Homo sapiens_hsa030221.92063205
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84686669
21RNA transport_Homo sapiens_hsa030131.80800095
22* RNA degradation_Homo sapiens_hsa030181.60542845
23Cell cycle_Homo sapiens_hsa041101.52363027
24Purine metabolism_Homo sapiens_hsa002301.46747633
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40606802
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39219908
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35231865
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24787529
29One carbon pool by folate_Homo sapiens_hsa006701.24416514
30Propanoate metabolism_Homo sapiens_hsa006401.10917592
31Cardiac muscle contraction_Homo sapiens_hsa042601.07873834
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07864407
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96370550
34mRNA surveillance pathway_Homo sapiens_hsa030150.96351858
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86267190
36Selenocompound metabolism_Homo sapiens_hsa004500.85963024
37Systemic lupus erythematosus_Homo sapiens_hsa053220.82141374
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80599507
39Folate biosynthesis_Homo sapiens_hsa007900.80189552
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80084722
41Epstein-Barr virus infection_Homo sapiens_hsa051690.76475545
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75936275
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72249523
44Fatty acid elongation_Homo sapiens_hsa000620.70240647
45p53 signaling pathway_Homo sapiens_hsa041150.69085053
46Caffeine metabolism_Homo sapiens_hsa002320.67768419
47Peroxisome_Homo sapiens_hsa041460.66343370
48Primary immunodeficiency_Homo sapiens_hsa053400.65881333
49Alcoholism_Homo sapiens_hsa050340.61285537
50Metabolic pathways_Homo sapiens_hsa011000.59636130
51Arachidonic acid metabolism_Homo sapiens_hsa005900.56709849
52Glutathione metabolism_Homo sapiens_hsa004800.56300746
53Butanoate metabolism_Homo sapiens_hsa006500.55227668
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.52812033
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52282706
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51345661
57Vibrio cholerae infection_Homo sapiens_hsa051100.49871165
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48251649
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47964061
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47400610
61Tryptophan metabolism_Homo sapiens_hsa003800.47320127
62N-Glycan biosynthesis_Homo sapiens_hsa005100.46409234
63Tyrosine metabolism_Homo sapiens_hsa003500.46226694
64Ether lipid metabolism_Homo sapiens_hsa005650.46161956
65Chemical carcinogenesis_Homo sapiens_hsa052040.45190139
66Phototransduction_Homo sapiens_hsa047440.44811412
67Asthma_Homo sapiens_hsa053100.43916999
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43567252
69Steroid biosynthesis_Homo sapiens_hsa001000.43441659
70Nitrogen metabolism_Homo sapiens_hsa009100.43065060
71Oocyte meiosis_Homo sapiens_hsa041140.41438044
72Vitamin B6 metabolism_Homo sapiens_hsa007500.41172880
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40908881
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39439675
75Vitamin digestion and absorption_Homo sapiens_hsa049770.38579811
76Herpes simplex infection_Homo sapiens_hsa051680.36749334
77Autoimmune thyroid disease_Homo sapiens_hsa053200.35224090
78Sulfur relay system_Homo sapiens_hsa041220.35082097
79Retinol metabolism_Homo sapiens_hsa008300.34945337
80Allograft rejection_Homo sapiens_hsa053300.34785955
81Collecting duct acid secretion_Homo sapiens_hsa049660.33733431
82Carbon metabolism_Homo sapiens_hsa012000.33458654
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33284703
84Sulfur metabolism_Homo sapiens_hsa009200.33278964
85Linoleic acid metabolism_Homo sapiens_hsa005910.33043559
86Regulation of autophagy_Homo sapiens_hsa041400.32365749
87Sphingolipid metabolism_Homo sapiens_hsa006000.30878130
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.30178662
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29583135
90Hematopoietic cell lineage_Homo sapiens_hsa046400.29065265
91Graft-versus-host disease_Homo sapiens_hsa053320.28133891
92Antigen processing and presentation_Homo sapiens_hsa046120.27305707
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26724916
94beta-Alanine metabolism_Homo sapiens_hsa004100.26156602
95Serotonergic synapse_Homo sapiens_hsa047260.25159832
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23984001
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22650232
98Type I diabetes mellitus_Homo sapiens_hsa049400.21965279
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.21959503
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.21443494
101Viral carcinogenesis_Homo sapiens_hsa052030.20716114
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20444218
103Biosynthesis of amino acids_Homo sapiens_hsa012300.20357776
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17218333
105Olfactory transduction_Homo sapiens_hsa047400.15369838
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15295669
107Arginine and proline metabolism_Homo sapiens_hsa003300.13503492
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12866952
109Phagosome_Homo sapiens_hsa041450.11599491
110Phenylalanine metabolism_Homo sapiens_hsa003600.11131410
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.09738338
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.07676088
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06931181
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05727971
115Other glycan degradation_Homo sapiens_hsa005110.05351608
116HTLV-I infection_Homo sapiens_hsa051660.05332036
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05325124
118Renin-angiotensin system_Homo sapiens_hsa046140.03422778
119Basal cell carcinoma_Homo sapiens_hsa052170.02978933
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.02718094
121Pentose phosphate pathway_Homo sapiens_hsa000300.02660991
122Rheumatoid arthritis_Homo sapiens_hsa053230.01984332
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.01558383
124Histidine metabolism_Homo sapiens_hsa003400.00980781
125Hedgehog signaling pathway_Homo sapiens_hsa043400.00761326
126Taste transduction_Homo sapiens_hsa047420.00436331
127Nicotine addiction_Homo sapiens_hsa05033-0.0204752
128Pyruvate metabolism_Homo sapiens_hsa00620-0.0154798

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