ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hyperosmotic salinity response (GO:0042538)	9.51160023
2	regulation of response to osmotic stress (GO:0047484)	8.31796822
3	vascular smooth muscle contraction (GO:0014829)	8.21950675
4	hypotonic response (GO:0006971)	7.90074379
5	histone mRNA catabolic process (GO:0071044)	7.68453484
6	negative regulation of cytosolic calcium ion concentration (GO:0051481)	7.49756006
7	ncRNA catabolic process (GO:0034661)	6.99006000
8	regulation of energy homeostasis (GO:2000505)	6.69352572
9	relaxation of smooth muscle (GO:0044557)	6.49843524
10	pteridine-containing compound biosynthetic process (GO:0042559)	6.44661307
11	piRNA metabolic process (GO:0034587)	5.99911739
12	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	5.99385888
13	sodium ion export (GO:0071436)	5.81832546
14	microtubule polymerization or depolymerization (GO:0031109)	5.65978309
15	inositol phosphate catabolic process (GO:0071545)	5.63065214
16	tryptophan catabolic process (GO:0006569)	5.55467371
17	indole-containing compound catabolic process (GO:0042436)	5.55467371
18	indolalkylamine catabolic process (GO:0046218)	5.55467371
19	post-embryonic morphogenesis (GO:0009886)	5.34548491
20	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	5.26139802
21	relaxation of cardiac muscle (GO:0055119)	5.23092012
22	limb bud formation (GO:0060174)	5.03666860
23	fatty acid homeostasis (GO:0055089)	4.89285396
24	glyoxylate metabolic process (GO:0046487)	4.87149771
25	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	4.73346415
26	carnitine shuttle (GO:0006853)	4.71265885
27	dendritic spine morphogenesis (GO:0060997)	4.67065955
28	glial cell proliferation (GO:0014009)	4.61908066
29	regulation of neuron migration (GO:2001222)	4.61583455
30	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	4.61384446
31	cellular sodium ion homeostasis (GO:0006883)	4.47146927
32	polyol catabolic process (GO:0046174)	4.43544411
33	response to pheromone (GO:0019236)	4.40933292
34	tryptophan metabolic process (GO:0006568)	4.40113560
35	calcium ion import (GO:0070509)	4.38051945
36	cardiac ventricle formation (GO:0003211)	4.37658056
37	positive regulation of protein depolymerization (GO:1901881)	4.31669188
38	spinal cord motor neuron differentiation (GO:0021522)	4.21754752
39	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.20971445
40	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.10295208
41	embryonic heart tube development (GO:0035050)	4.05497849
42	regulation of timing of cell differentiation (GO:0048505)	4.05084266
43	kidney morphogenesis (GO:0060993)	4.02796607
44	entrainment of circadian clock (GO:0009649)	4.00581857
45	histone-serine phosphorylation (GO:0035404)	4.00509457
46	cardiac chamber formation (GO:0003207)	3.99398536
47	fatty acid transmembrane transport (GO:1902001)	3.97189987
48	histone mRNA metabolic process (GO:0008334)	3.93656183
49	DNA damage response, detection of DNA damage (GO:0042769)	3.86770431
50	neural tube formation (GO:0001841)	3.80142824
51	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.78718262
52	positive regulation of glycolytic process (GO:0045821)	3.76063391
53	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.75184871
54	DNA methylation involved in gamete generation (GO:0043046)	3.74595895
55	carnitine transmembrane transport (GO:1902603)	3.72778570
56	epithelial structure maintenance (GO:0010669)	3.66687436
57	response to caffeine (GO:0031000)	3.63850643
58	regulation of development, heterochronic (GO:0040034)	3.56934315
59	cellular biogenic amine catabolic process (GO:0042402)	3.54110034
60	amine catabolic process (GO:0009310)	3.54110034
61	single strand break repair (GO:0000012)	3.52513245
62	cytoplasmic microtubule organization (GO:0031122)	3.48163056
63	cellular response to glucose starvation (GO:0042149)	3.47844409
64	amino-acid betaine transport (GO:0015838)	3.47114902
65	carnitine transport (GO:0015879)	3.47114902
66	response to salt stress (GO:0009651)	3.46801367
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.45946466
68	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.43216709
69	cell communication by electrical coupling (GO:0010644)	3.43169112
70	indolalkylamine metabolic process (GO:0006586)	3.40787105
71	kynurenine metabolic process (GO:0070189)	3.40366245
72	serine family amino acid catabolic process (GO:0009071)	3.38845924
73	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.38166469
74	meiotic cell cycle (GO:0051321)	3.37252019
75	response to inactivity (GO:0014854)	3.37169586
76	vasoconstriction (GO:0042310)	3.35577517
77	regulation of axon extension involved in axon guidance (GO:0048841)	3.31817591
78	cardiac right ventricle morphogenesis (GO:0003215)	3.30391199
79	cell volume homeostasis (GO:0006884)	3.29932566
80	lymphoid progenitor cell differentiation (GO:0002320)	3.29690682
81	positive regulation of protein complex disassembly (GO:0043243)	3.27673512
82	dendrite morphogenesis (GO:0048813)	3.24308422
83	cell differentiation in spinal cord (GO:0021515)	3.22689572
84	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.20255835
85	gamma-aminobutyric acid transport (GO:0015812)	3.19685906
86	atrial septum morphogenesis (GO:0060413)	3.19566693
87	cerebral cortex neuron differentiation (GO:0021895)	3.17048615
88	clathrin coat assembly (GO:0048268)	3.16791320
89	neuronal action potential (GO:0019228)	3.10494846
90	rRNA catabolic process (GO:0016075)	3.10473929
91	cellular response to heat (GO:0034605)	3.09568537
92	pteridine-containing compound metabolic process (GO:0042558)	3.07839475
93	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.05975000
94	L-serine metabolic process (GO:0006563)	3.03974479
95	somatic stem cell maintenance (GO:0035019)	2.99361486
96	relaxation of muscle (GO:0090075)	2.98214150
97	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.95639871
98	regulation of axon guidance (GO:1902667)	2.93306368
99	cellular response to osmotic stress (GO:0071470)	2.89848237
100	pre-miRNA processing (GO:0031054)	10.2553475

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.32751154
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.93359449
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.36530573
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.91201940
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.46342945
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.09535209
7	HTT_18923047_ChIP-ChIP_STHdh_Human	2.88141557
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.83621512
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.83170857
10	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.73686152
11	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.73686152
12	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.29078650
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.11472391
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.07479229
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03798113
16	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.98796274
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97392420
18	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.90458230
19	VDR_22108803_ChIP-Seq_LS180_Human	1.86609286
20	P300_19829295_ChIP-Seq_ESCs_Human	1.82979182
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.82601897
22	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.81244258
23	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.78205396
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73081159
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66502186
26	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61441358
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61355111
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.60975825
29	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.56176268
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51867907
31	EWS_26573619_Chip-Seq_HEK293_Human	1.50734553
32	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.49765562
33	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.49548066
34	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48465288
35	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.48398028
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.48129299
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45920994
38	FUS_26573619_Chip-Seq_HEK293_Human	1.45565778
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42267913
40	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.41622704
41	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.38393462
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38355727
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37641980
44	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.36638588
45	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.36406574
46	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.36372962
47	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36050610
48	TP53_16413492_ChIP-PET_HCT116_Human	1.35783951
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35629223
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30519931
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27339172
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26711213
53	EGR1_19032775_ChIP-ChIP_M12_Human	1.25670142
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19894921
55	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.18188073
56	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.17628283
57	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17623273
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17575483
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14912716
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14241986
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.13910526
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12792996
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12485515
64	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.12184440
65	STAT3_23295773_ChIP-Seq_U87_Human	1.07070110
66	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06168654
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04040832
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.04040832
69	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.02707543
70	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.02107123
71	OCT4_20526341_ChIP-Seq_ESCs_Human	1.01308235
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01181545
73	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.00190503
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99968369
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99199300
76	CBP_21632823_ChIP-Seq_H3396_Human	0.98231715
77	ER_23166858_ChIP-Seq_MCF-7_Human	0.98221285
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.98105433
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.97389082
80	AR_19668381_ChIP-Seq_PC3_Human	0.97227320
81	KDM2B_26808549_Chip-Seq_REH_Human	0.95954356
82	RXR_22108803_ChIP-Seq_LS180_Human	0.94343173
83	TP53_22127205_ChIP-Seq_IMR90_Human	0.94000406
84	AR_25329375_ChIP-Seq_VCAP_Human	0.93318432
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93042994
86	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92911292
87	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.92703001
88	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.92392810
89	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.92189419
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.91575375
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90524631
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.88341173
93	TCF4_23295773_ChIP-Seq_U87_Human	0.87206564
94	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.87134792
95	NCOR_22424771_ChIP-Seq_293T_Human	0.86198528
96	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.85024221
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84936006
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84732233
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.83940304
100	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.83519128

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	8.84180702
2	MP0003880_abnormal_central_pattern	8.63728630
3	MP0009278_abnormal_bone_marrow	3.81911341
4	MP0002735_abnormal_chemical_nociception	3.76191975
5	MP0004133_heterotaxia	3.32850727
6	MP0004084_abnormal_cardiac_muscle	3.04963867
7	MP0003890_abnormal_embryonic-extraembry	2.61722805
8	MP0003950_abnormal_plasma_membrane	2.50920033
9	MP0002876_abnormal_thyroid_physiology	2.40389830
10	MP0003878_abnormal_ear_physiology	2.39809683
11	MP0005377_hearing/vestibular/ear_phenot	2.39809683
12	MP0001986_abnormal_taste_sensitivity	2.38037805
13	MP0002734_abnormal_mechanical_nocicepti	2.25030746
14	MP0006276_abnormal_autonomic_nervous	2.18006400
15	MP0004130_abnormal_muscle_cell	2.00957949
16	MP0000015_abnormal_ear_pigmentation	1.97873141
17	MP0005551_abnormal_eye_electrophysiolog	1.91558375
18	MP0000467_abnormal_esophagus_morphology	1.78867087
19	MP0004885_abnormal_endolymph	1.75734474
20	MP0003011_delayed_dark_adaptation	1.70097462
21	MP0000537_abnormal_urethra_morphology	1.66378250
22	MP0008775_abnormal_heart_ventricle	1.64255345
23	MP0000569_abnormal_digit_pigmentation	1.59072702
24	MP0002102_abnormal_ear_morphology	1.51475260
25	MP0002282_abnormal_trachea_morphology	1.47164021
26	MP0004036_abnormal_muscle_relaxation	1.43414748
27	MP0009053_abnormal_anal_canal	1.42770567
28	MP0009745_abnormal_behavioral_response	1.40537242
29	MP0003221_abnormal_cardiomyocyte_apopto	1.39519670
30	MP0006292_abnormal_olfactory_placode	1.39427775
31	MP0001299_abnormal_eye_distance/	1.32257237
32	MP0001545_abnormal_hematopoietic_system	1.29645932
33	MP0005397_hematopoietic_system_phenotyp	1.29645932
34	MP0002132_abnormal_respiratory_system	1.28664361
35	MP0006035_abnormal_mitochondrial_morpho	1.26150030
36	MP0005448_abnormal_energy_balance	1.12023206
37	MP0003866_abnormal_defecation	1.08866548
38	MP0001970_abnormal_pain_threshold	1.07906053
39	MP0001963_abnormal_hearing_physiology	1.07178005
40	MP0002751_abnormal_autonomic_nervous	1.05077048
41	MP0005670_abnormal_white_adipose	1.05069451
42	MP0004859_abnormal_synaptic_plasticity	1.03717071
43	MP0006072_abnormal_retinal_apoptosis	1.01529009
44	MP0001542_abnormal_bone_strength	0.98393187
45	MP0004742_abnormal_vestibular_system	0.97317773
46	MP0003283_abnormal_digestive_organ	0.92876254
47	MP0003938_abnormal_ear_development	0.91422925
48	MP0002277_abnormal_respiratory_mucosa	0.88448735
49	MP0000462_abnormal_digestive_system	0.88054756
50	MP0002933_joint_inflammation	0.87779112
51	MP0000681_abnormal_thyroid_gland	0.85623493
52	MP0003646_muscle_fatigue	0.84214229
53	MP0002234_abnormal_pharynx_morphology	0.81158640
54	MP0002090_abnormal_vision	0.81155948
55	MP0005503_abnormal_tendon_morphology	0.78732247
56	MP0000516_abnormal_urinary_system	0.78661873
57	MP0005367_renal/urinary_system_phenotyp	0.78661873
58	MP0002064_seizures	0.76761612
59	MP0003195_calcinosis	0.76329429
60	MP0000049_abnormal_middle_ear	0.75001245
61	MP0002069_abnormal_eating/drinking_beha	0.74797808
62	MP0001486_abnormal_startle_reflex	0.74417521
63	MP0004085_abnormal_heartbeat	0.73957556
64	MP0002693_abnormal_pancreas_physiology	0.72199973
65	MP0002272_abnormal_nervous_system	0.70449581
66	MP0002822_catalepsy	0.70128307
67	MP0009250_abnormal_appendicular_skeleto	0.67837207
68	MP0003693_abnormal_embryo_hatching	0.67649757
69	MP0000026_abnormal_inner_ear	0.67459361
70	MP0003755_abnormal_palate_morphology	0.67442754
71	MP0002067_abnormal_sensory_capabilities	0.66723418
72	MP0001485_abnormal_pinna_reflex	0.66624389
73	MP0000538_abnormal_urinary_bladder	0.64789111
74	MP0002736_abnormal_nociception_after	0.62207425
75	MP0004134_abnormal_chest_morphology	0.60328938
76	MP0002160_abnormal_reproductive_system	0.60155948
77	MP0001666_abnormal_nutrient_absorption	0.58495356
78	MP0002752_abnormal_somatic_nervous	0.58483785
79	MP0000631_abnormal_neuroendocrine_gland	0.58340249
80	MP0008872_abnormal_physiological_respon	0.58151993
81	MP0008961_abnormal_basal_metabolism	0.57150880
82	MP0008058_abnormal_DNA_repair	0.57044493
83	MP0002572_abnormal_emotion/affect_behav	0.57004196
84	MP0001984_abnormal_olfaction	0.56388434
85	MP0000383_abnormal_hair_follicle	0.55820947
86	MP0005253_abnormal_eye_physiology	0.55453071
87	MP0005167_abnormal_blood-brain_barrier	0.53796752
88	MP0008875_abnormal_xenobiotic_pharmacok	0.53224376
89	MP0002177_abnormal_outer_ear	0.51577843
90	MP0003879_abnormal_hair_cell	0.51113942
91	MP0005195_abnormal_posterior_eye	0.50301624
92	MP0009115_abnormal_fat_cell	0.50235960
93	MP0010386_abnormal_urinary_bladder	0.49374950
94	MP0003119_abnormal_digestive_system	0.49037752
95	MP0008770_decreased_survivor_rate	0.46980621
96	MP0003635_abnormal_synaptic_transmissio	0.46944202
97	MP0005085_abnormal_gallbladder_physiolo	0.46888651
98	MP0005220_abnormal_exocrine_pancreas	0.46200654
99	MP0002233_abnormal_nose_morphology	0.45835189
100	MP0002116_abnormal_craniofacial_bone	0.45271691

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia of the musculature (HP:0100854)	7.62183970
2	Hip contracture (HP:0003273)	6.56737051
3	Muscle fiber splitting (HP:0003555)	6.49559431
4	Carpal bone hypoplasia (HP:0001498)	6.41328099
5	Fetal akinesia sequence (HP:0001989)	6.37530420
6	Diaphragmatic weakness (HP:0009113)	6.27328393
7	Hip dysplasia (HP:0001385)	6.26583825
8	Spinal muscular atrophy (HP:0007269)	5.93137087
9	Hand muscle atrophy (HP:0009130)	5.91481699
10	Stridor (HP:0010307)	5.88525560
11	Obstructive sleep apnea (HP:0002870)	5.68206351
12	Abnormality of the middle phalanges of the toes (HP:0010183)	5.64557512
13	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	5.36459944
14	Aplasia/Hypoplasia involving the musculature (HP:0001460)	5.30436767
15	Distal lower limb muscle weakness (HP:0009053)	5.21819004
16	Flat acetabular roof (HP:0003180)	5.14885486
17	Abnormality of the distal phalanges of the toes (HP:0010182)	4.90347067
18	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	4.82579612
19	Limited hip movement (HP:0008800)	4.57900757
20	Distal upper limb amyotrophy (HP:0007149)	4.51060048
21	Upper limb amyotrophy (HP:0009129)	4.51060048
22	Down-sloping shoulders (HP:0200021)	4.40865879
23	Disproportionate short-trunk short stature (HP:0003521)	4.33646624
24	Spinal cord compression (HP:0002176)	4.21718662
25	Limb-girdle muscle atrophy (HP:0003797)	4.19417173
26	Barrel-shaped chest (HP:0001552)	4.07566357
27	Hypoplasia of the odontoid process (HP:0003311)	3.89916010
28	Difficulty running (HP:0009046)	3.86002150
29	Scapular winging (HP:0003691)	3.82295604
30	Abnormality of the vocal cords (HP:0008777)	3.78285300
31	Epiphyseal dysplasia (HP:0002656)	3.74290492
32	Short tibia (HP:0005736)	3.65928204
33	Sleep apnea (HP:0010535)	3.65545544
34	Abnormal vertebral ossification (HP:0100569)	3.60601085
35	Abnormality of the phalanges of the hallux (HP:0010057)	3.55144525
36	Knee flexion contracture (HP:0006380)	3.41505857
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.39887672
38	Nonprogressive disorder (HP:0003680)	3.36319318
39	Broad-based gait (HP:0002136)	3.35514195
40	Supernumerary spleens (HP:0009799)	3.34573693
41	Abnormality of carpal bone ossification (HP:0006257)	3.31814691
42	Abnormality of the odontoid process (HP:0003310)	3.20870214
43	Lower limb asymmetry (HP:0100559)	3.15790945
44	Short femoral neck (HP:0100864)	3.10189041
45	Metaphyseal irregularity (HP:0003025)	3.05196406
46	Gowers sign (HP:0003391)	2.98479935
47	Abnormality of the intervertebral disk (HP:0005108)	2.97767770
48	Small hand (HP:0200055)	2.78330297
49	Urinary urgency (HP:0000012)	2.69962177
50	Torticollis (HP:0000473)	2.68872861
51	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.68660707
52	Abnormality of the calf musculature (HP:0001430)	2.63828174
53	Long foot (HP:0001833)	2.57756015
54	Abnormality of the shoulder girdle musculature (HP:0001435)	2.56894534
55	Rough bone trabeculation (HP:0100670)	2.49982716
56	Achilles tendon contracture (HP:0001771)	2.46659855
57	Abnormality of the musculature of the hand (HP:0001421)	2.45298185
58	Short middle phalanx of finger (HP:0005819)	2.44255681
59	Abnormal hand bone ossification (HP:0010660)	2.43776658
60	Abnormal ossification of hand bones (HP:0005921)	2.37104395
61	Anencephaly (HP:0002323)	2.27827873
62	Aplasia/hypoplasia of the femur (HP:0005613)	2.24558856
63	Abnormality of the Achilles tendon (HP:0005109)	2.20042562
64	Craniofacial dystonia (HP:0012179)	2.17059955
65	Median cleft lip (HP:0000161)	2.13120604
66	Waddling gait (HP:0002515)	2.12925981
67	Midline defect of the nose (HP:0004122)	2.12685766
68	Genu varum (HP:0002970)	2.07433885
69	Coxa vara (HP:0002812)	2.03501637
70	Proximal amyotrophy (HP:0007126)	2.01776006
71	Focal dystonia (HP:0004373)	1.99770459
72	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.98324014
73	Hypothermia (HP:0002045)	1.94363100
74	Abnormal trabecular bone morphology (HP:0100671)	1.94128051
75	Flared metaphyses (HP:0003015)	1.90549407
76	Absent septum pellucidum (HP:0001331)	1.84047670
77	Absent toe (HP:0010760)	1.83903500
78	Aplasia/Hypoplasia involving the vertebral column (HP:0008518)	1.81452398
79	Pancreatic cysts (HP:0001737)	1.77902421
80	Complete atrioventricular canal defect (HP:0001674)	1.76336381
81	Severe short stature (HP:0003510)	1.74537333
82	Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)	1.74087029
83	True hermaphroditism (HP:0010459)	1.70805247
84	Stillbirth (HP:0003826)	1.70538261
85	Molar tooth sign on MRI (HP:0002419)	1.67778898
86	Abnormality of midbrain morphology (HP:0002418)	1.67778898
87	Methylmalonic acidemia (HP:0002912)	1.66239152
88	Preaxial hand polydactyly (HP:0001177)	1.65767191
89	Renal cortical cysts (HP:0000803)	1.65241873
90	Metatarsus adductus (HP:0001840)	1.64510330
91	Pancreatic fibrosis (HP:0100732)	1.63717153
92	Atrioventricular canal defect (HP:0006695)	1.60063119
93	Abnormality of the humerus (HP:0003063)	1.58967485
94	Cortical dysplasia (HP:0002539)	1.56970813
95	Asymmetric growth (HP:0100555)	1.56748413
96	Abnormal lung lobation (HP:0002101)	1.56112863
97	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.55272937
98	Abnormality of the upper arm (HP:0001454)	1.52704604
99	Tubulointerstitial nephritis (HP:0001970)	1.50737363
100	Abnormality of the middle phalanges of the hand (HP:0009833)	1.44541223

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K7	4.03713193
2	MARK1	3.82681511
3	CLK1	3.82143522
4	FER	2.72198850
5	MAP2K7	2.64111110
6	STK39	2.62263298
7	EPHA3	2.56726379
8	FRK	2.52106343
9	MAP3K4	2.40704563
10	TNIK	2.39442459
11	TLK1	2.16903226
12	PASK	2.16517059
13	OXSR1	1.99874491
14	FES	1.98896292
15	STK11	1.98345504
16	NME1	1.94303188
17	WNK4	1.91440885
18	EPHB1	1.85593299
19	STK4	1.84374900
20	BCKDK	1.83741904
21	CASK	1.83703656
22	ACVR1B	1.74154307
23	RPS6KA4	1.71433596
24	NUAK1	1.67185495
25	BMPR1B	1.60429645
26	EPHA4	1.59303936
27	MAP4K2	1.51238850
28	STK3	1.50525879
29	TYRO3	1.49217105
30	BRD4	1.47822646
31	INSRR	1.32972724
32	KDR	1.32603207
33	STK38	1.26987134
34	PRKAA1	1.22892555
35	WNK3	1.11849787
36	CDK19	1.09760754
37	ADRBK2	1.07791075
38	NLK	1.07475613
39	CDC7	1.06473048
40	PLK4	1.05245489
41	PRKAA2	1.05202074
42	TGFBR1	0.90747502
43	TNK2	0.86171799
44	LYN	0.85141103
45	MAPKAPK3	0.79648323
46	FGFR2	0.77538835
47	STK24	0.75692956
48	MAP3K6	0.75488900
49	ITK	0.73000726
50	MUSK	0.72122371
51	TEC	0.70022157
52	CAMKK1	0.69911102
53	MKNK2	0.68106618
54	CAMK1	0.67230136
55	MAP2K4	0.65131736
56	LATS1	0.64125653
57	HCK	0.60765643
58	FGFR4	0.59864377
59	EIF2AK1	0.59195792
60	CSNK1G1	0.58749446
61	SGK1	0.58019292
62	KIT	0.57640525
63	CSNK1G2	0.56293723
64	TXK	0.56285681
65	MAPK13	0.55387662
66	PRKCE	0.55201320
67	ERBB3	0.55035247
68	PAK3	0.53340958
69	MAPK15	0.53332462
70	BCR	0.53218402
71	LMTK2	0.50904475
72	PIK3CG	0.50139299
73	EIF2AK3	0.49793846
74	RPS6KA5	0.48669260
75	PRKCA	0.48620612
76	CDK3	0.47841766
77	DYRK2	0.47177060
78	CSNK1G3	0.46584860
79	PRKACA	0.45691498
80	CDK1	0.44434776
81	PRKACG	0.42994904
82	ADRBK1	0.42392498
83	PLK2	0.41586954
84	PRKCD	0.41302109
85	GRK1	0.40024877
86	TTK	0.39240868
87	CSNK1A1L	0.38105953
88	GSK3B	0.37563207
89	MAP3K10	0.37093260
90	MAP2K1	0.36333915
91	MAPK4	0.34494688
92	CCNB1	0.34461139
93	OBSCN	0.34399004
94	TESK2	0.33631350
95	ALK	0.33618082
96	MAPK9	0.33579964
97	ERBB4	0.31099888
98	FGFR3	0.30540497
99	TRIM28	0.29745397
100	MET	0.28973940

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.12980150
2	Regulation of autophagy_Homo sapiens_hsa04140	3.50753597
3	Protein export_Homo sapiens_hsa03060	3.05755908
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.75443462
5	Circadian rhythm_Homo sapiens_hsa04710	2.64261091
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.55168242
7	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.51633522
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.36727719
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.28120552
10	RNA degradation_Homo sapiens_hsa03018	2.25274842
11	Nicotine addiction_Homo sapiens_hsa05033	2.24067693
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.22904046
13	Phototransduction_Homo sapiens_hsa04744	2.17673179
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08838214
15	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.86511689
16	Mineral absorption_Homo sapiens_hsa04978	1.83554629
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.78508730
18	GABAergic synapse_Homo sapiens_hsa04727	1.78077532
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.76888054
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.75166776
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.72939579
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67344801
23	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.60616950
24	Propanoate metabolism_Homo sapiens_hsa00640	1.54483847
25	ABC transporters_Homo sapiens_hsa02010	1.43727028
26	Olfactory transduction_Homo sapiens_hsa04740	1.41870769
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40129491
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.31991404
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30702632
30	Taste transduction_Homo sapiens_hsa04742	1.23890584
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22841094
32	Base excision repair_Homo sapiens_hsa03410	1.22405195
33	RNA polymerase_Homo sapiens_hsa03020	1.20831222
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.17955233
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.14922005
36	Morphine addiction_Homo sapiens_hsa05032	1.14154013
37	Retinol metabolism_Homo sapiens_hsa00830	1.11651296
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.10672782
39	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.09210753
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.08791116
41	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.07486908
42	Caffeine metabolism_Homo sapiens_hsa00232	1.01494234
43	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01364249
44	Sulfur metabolism_Homo sapiens_hsa00920	0.99945055
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.95902655
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89734135
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.89717426
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.86250213
49	Protein digestion and absorption_Homo sapiens_hsa04974	0.84648559
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.82977166
51	Parkinsons disease_Homo sapiens_hsa05012	0.81911580
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77399151
53	Basal transcription factors_Homo sapiens_hsa03022	0.71728023
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70918349
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69701457
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68391057
57	Serotonergic synapse_Homo sapiens_hsa04726	0.66692496
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.65439627
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.63306925
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62687603
61	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.61751567
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.61026518
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59155300
64	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55209256
65	Allograft rejection_Homo sapiens_hsa05330	0.54928509
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54688803
67	Peroxisome_Homo sapiens_hsa04146	0.54658903
68	Alzheimers disease_Homo sapiens_hsa05010	0.54532775
69	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54297159
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.51835065
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51317383
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49046967
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49024154
74	Ribosome_Homo sapiens_hsa03010	0.48980124
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48068375
76	Proteasome_Homo sapiens_hsa03050	0.47544560
77	Butanoate metabolism_Homo sapiens_hsa00650	0.47328605
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45895534
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45836681
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45417924
81	Histidine metabolism_Homo sapiens_hsa00340	0.45048764
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44743413
83	Metabolic pathways_Homo sapiens_hsa01100	0.44395348
84	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42750664
85	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41521970
86	Circadian entrainment_Homo sapiens_hsa04713	0.41427150
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.39850748
88	Insulin resistance_Homo sapiens_hsa04931	0.39326869
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36794618
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.34583962
91	Huntingtons disease_Homo sapiens_hsa05016	0.34423027
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33769951
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.32551847
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.31603721
95	Purine metabolism_Homo sapiens_hsa00230	0.31537543
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.31348942
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.30955446
98	RNA transport_Homo sapiens_hsa03013	0.29055690
99	Notch signaling pathway_Homo sapiens_hsa04330	0.24002501
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.23571099

LSM6P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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