LSM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.26905887
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.79747228
3ATP synthesis coupled proton transport (GO:0015986)6.79747228
4ribosomal small subunit biogenesis (GO:0042274)6.33730733
5viral transcription (GO:0019083)5.86103920
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.80497167
7ribosomal small subunit assembly (GO:0000028)5.64445587
8translational termination (GO:0006415)5.63976436
9respiratory electron transport chain (GO:0022904)5.13643338
10cotranslational protein targeting to membrane (GO:0006613)5.10025228
11proteasome assembly (GO:0043248)5.06690568
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.05484178
13maturation of SSU-rRNA (GO:0030490)5.03017703
14electron transport chain (GO:0022900)5.00875658
15protein targeting to ER (GO:0045047)5.00673000
16chaperone-mediated protein transport (GO:0072321)4.93382619
17protein neddylation (GO:0045116)4.88541634
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.77045294
19protein localization to endoplasmic reticulum (GO:0070972)4.76811194
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.70267478
21translational elongation (GO:0006414)4.68032188
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.54901326
23termination of RNA polymerase III transcription (GO:0006386)4.54901326
24ribosomal large subunit biogenesis (GO:0042273)4.51305786
25cellular protein complex disassembly (GO:0043624)4.49567403
26viral life cycle (GO:0019058)4.49558576
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.42075248
28DNA deamination (GO:0045006)4.41580176
29establishment of integrated proviral latency (GO:0075713)4.38889012
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.37246481
31NADH dehydrogenase complex assembly (GO:0010257)4.37246481
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.37246481
33protein complex biogenesis (GO:0070271)4.36001623
34GTP biosynthetic process (GO:0006183)4.33625357
35translational initiation (GO:0006413)4.22629658
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.19674503
37translation (GO:0006412)4.04419953
38mitochondrial respiratory chain complex assembly (GO:0033108)4.01005923
397-methylguanosine mRNA capping (GO:0006370)3.98728298
407-methylguanosine RNA capping (GO:0009452)3.98300207
41RNA capping (GO:0036260)3.98300207
42cytochrome complex assembly (GO:0017004)3.93608537
43oxidative phosphorylation (GO:0006119)3.82262090
44protein complex disassembly (GO:0043241)3.81192413
45base-excision repair, AP site formation (GO:0006285)3.79231437
46UTP biosynthetic process (GO:0006228)3.75672273
47establishment of viral latency (GO:0019043)3.71672291
48deoxyribonucleotide catabolic process (GO:0009264)3.68459123
49ribonucleoprotein complex biogenesis (GO:0022613)3.66010146
50macromolecular complex disassembly (GO:0032984)3.65752107
51protein targeting to mitochondrion (GO:0006626)3.63414317
52pyrimidine nucleotide catabolic process (GO:0006244)3.59710326
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59533964
54regulation of mitochondrial translation (GO:0070129)3.57586757
55pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.56688146
56establishment of protein localization to mitochondrion (GO:0072655)3.56181611
57cellular component biogenesis (GO:0044085)3.55702621
58deoxyribose phosphate catabolic process (GO:0046386)3.55540014
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53449774
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53449774
61deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.53305619
62transcription elongation from RNA polymerase I promoter (GO:0006362)3.48687247
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.41847258
64regulation of cellular amino acid metabolic process (GO:0006521)3.40807121
65guanosine-containing compound biosynthetic process (GO:1901070)3.38040153
66* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37737738
67maturation of 5.8S rRNA (GO:0000460)3.37469849
68respiratory chain complex IV assembly (GO:0008535)3.35922124
69peptidyl-histidine modification (GO:0018202)3.35756442
70cullin deneddylation (GO:0010388)3.35096517
71negative regulation of ligase activity (GO:0051352)3.34626032
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34626032
73rRNA processing (GO:0006364)3.34530511
74DNA strand elongation involved in DNA replication (GO:0006271)3.34398330
75telomere maintenance via semi-conservative replication (GO:0032201)3.34094552
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33816711
77DNA damage response, detection of DNA damage (GO:0042769)3.31839951
78purine nucleoside triphosphate biosynthetic process (GO:0009145)3.31518647
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29625471
80spliceosomal snRNP assembly (GO:0000387)3.29096038
81* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27859491
82spliceosomal complex assembly (GO:0000245)3.27417965
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27187123
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27187123
85purine deoxyribonucleotide catabolic process (GO:0009155)3.26295253
86iron-sulfur cluster assembly (GO:0016226)3.25075260
87metallo-sulfur cluster assembly (GO:0031163)3.25075260
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24668570
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24668570
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24668570
91protein localization to mitochondrion (GO:0070585)3.21330252
92DNA strand elongation (GO:0022616)3.20568345
93rRNA metabolic process (GO:0016072)3.20442651
94protein targeting to membrane (GO:0006612)3.19958952
95negative regulation of B cell apoptotic process (GO:0002903)3.19727418
96termination of RNA polymerase I transcription (GO:0006363)3.19716053
97pseudouridine synthesis (GO:0001522)3.19598561
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17917197
99pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.17886878
100ATP biosynthetic process (GO:0006754)3.15624945
101signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15102140
102signal transduction involved in DNA damage checkpoint (GO:0072422)3.15102140
103protein deneddylation (GO:0000338)3.13790260
104* nuclear-transcribed mRNA catabolic process (GO:0000956)3.13557052
105signal transduction involved in cell cycle checkpoint (GO:0072395)3.12546847
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12115308
107UTP metabolic process (GO:0046051)3.10852322
108hydrogen ion transmembrane transport (GO:1902600)3.10040590
109transcription from RNA polymerase I promoter (GO:0006360)3.09407687
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08196388
111CTP biosynthetic process (GO:0006241)3.08092644
112CTP metabolic process (GO:0046036)3.08092644
113transcription-coupled nucleotide-excision repair (GO:0006283)3.06106093
114rRNA modification (GO:0000154)3.06013809
1152-deoxyribonucleotide metabolic process (GO:0009394)3.04467124
116ribonucleoside triphosphate biosynthetic process (GO:0009201)3.03126230
117purine nucleobase biosynthetic process (GO:0009113)3.00466300
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00300771
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99658711
120* mRNA catabolic process (GO:0006402)2.97821267
121pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.97164870
122viral mRNA export from host cell nucleus (GO:0046784)2.94611702
123dopamine transport (GO:0015872)2.93020459
124inner mitochondrial membrane organization (GO:0007007)2.92455000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.22896852
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71782582
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.24315885
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.08713039
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.83153268
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71479833
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.65843000
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62732513
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.46663122
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.36500599
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.22652524
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09824898
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.01090355
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97741357
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55309419
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46302358
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37109682
18VDR_23849224_ChIP-Seq_CD4+_Human2.29995403
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28074206
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26507205
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24691222
22ELK1_19687146_ChIP-ChIP_HELA_Human2.23024571
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19667426
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06597141
25DCP1A_22483619_ChIP-Seq_HELA_Human2.04109804
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.04015435
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.99019200
28TTF2_22483619_ChIP-Seq_HELA_Human1.97850078
29E2F7_22180533_ChIP-Seq_HELA_Human1.95506948
30XRN2_22483619_ChIP-Seq_HELA_Human1.93346316
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92973634
32FOXP3_21729870_ChIP-Seq_TREG_Human1.89380238
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89297293
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81997916
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81678594
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79984913
37EZH2_22144423_ChIP-Seq_EOC_Human1.69019848
38IRF1_19129219_ChIP-ChIP_H3396_Human1.65612045
39CIITA_25753668_ChIP-Seq_RAJI_Human1.64632323
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61848289
41TAF15_26573619_Chip-Seq_HEK293_Human1.60261040
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.59894293
43FUS_26573619_Chip-Seq_HEK293_Human1.59808772
44VDR_22108803_ChIP-Seq_LS180_Human1.56957545
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55577659
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55255989
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54655646
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51599821
49MYC_18940864_ChIP-ChIP_HL60_Human1.47507570
50KDM5A_27292631_Chip-Seq_BREAST_Human1.45778171
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44804886
52* GABP_19822575_ChIP-Seq_HepG2_Human1.43999592
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42412641
54* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41439875
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39328206
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38825880
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38129939
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34611544
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31833035
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28338768
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25543802
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24280673
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23832544
64EWS_26573619_Chip-Seq_HEK293_Human1.22413313
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18304052
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17522524
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.17343053
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16383636
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14808464
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.13294084
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11422741
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11014513
73* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10604932
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08777172
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08343971
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08062169
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07977690
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06890492
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05994461
80RNF2_27304074_Chip-Seq_NSC_Mouse1.03683500
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.03643110
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03523925
83GBX2_23144817_ChIP-Seq_PC3_Human1.03336030
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.02572544
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.01932833
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01831817
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99425860
88IGF1R_20145208_ChIP-Seq_DFB_Human0.98118180
89* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97643016
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97491291
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97458286
92BCL6_27268052_Chip-Seq_Bcells_Human0.95991558
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95361289
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.95082430
95CTCF_26484167_Chip-Seq_Bcells_Mouse0.94226118
96VDR_21846776_ChIP-Seq_THP-1_Human0.93882785
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92706423
98* YY1_22570637_ChIP-Seq_MALME-3M_Human0.92682833
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92353087
100* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92048964
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92030943
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91810635
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91569998
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91553773
105* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89462078
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89435997
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.89308393
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89030203
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88833707
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87065962
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86220775
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85978489
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85803186
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84413419
115EZH2_27304074_Chip-Seq_ESCs_Mouse0.83900864
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83514398
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82449581
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81741111
119ZNF274_21170338_ChIP-Seq_K562_Hela0.79635069
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79556288
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79487206
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.79436376
123ER_23166858_ChIP-Seq_MCF-7_Human0.78747070
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.78495714
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.78222384
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78024731
127SPI1_23547873_ChIP-Seq_NB4_Human0.76675444
128* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74407201
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73679287
130TP63_19390658_ChIP-ChIP_HaCaT_Human0.73103141
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71589848
132NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71364666
133P300_19829295_ChIP-Seq_ESCs_Human0.70836240
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70596446
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70014759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.62898416
2MP0003880_abnormal_central_pattern4.09324453
3MP0001529_abnormal_vocalization3.62093470
4MP0003806_abnormal_nucleotide_metabolis3.60725703
5MP0003136_yellow_coat_color2.92305245
6MP0001905_abnormal_dopamine_level2.75914667
7MP0001188_hyperpigmentation2.53313248
8MP0006292_abnormal_olfactory_placode2.45949456
9MP0006276_abnormal_autonomic_nervous2.30317134
10MP0005409_darkened_coat_color2.20938937
11MP0008057_abnormal_DNA_replication2.19589513
12MP0000372_irregular_coat_pigmentation1.98410203
13MP0008007_abnormal_cellular_replicative1.96826944
14MP0009697_abnormal_copulation1.95900640
15MP0002736_abnormal_nociception_after1.92050156
16MP0004381_abnormal_hair_follicle1.90106185
17MP0005171_absent_coat_pigmentation1.89063139
18MP0004957_abnormal_blastocyst_morpholog1.85230071
19MP0001968_abnormal_touch/_nociception1.84997228
20MP0002102_abnormal_ear_morphology1.83633124
21MP0004142_abnormal_muscle_tone1.83246019
22MP0003693_abnormal_embryo_hatching1.80699020
23MP0002938_white_spotting1.78981790
24MP0008058_abnormal_DNA_repair1.77396984
25MP0005084_abnormal_gallbladder_morpholo1.74900302
26MP0002638_abnormal_pupillary_reflex1.74304924
27MP0003718_maternal_effect1.66518978
28MP0005075_abnormal_melanosome_morpholog1.63312331
29MP0002653_abnormal_ependyma_morphology1.63266523
30MP0005423_abnormal_somatic_nervous1.58465691
31MP0002272_abnormal_nervous_system1.58076921
32MP0008932_abnormal_embryonic_tissue1.56439615
33MP0009333_abnormal_splenocyte_physiolog1.54517986
34MP0003315_abnormal_perineum_morphology1.51051199
35MP0003786_premature_aging1.49739715
36MP0001485_abnormal_pinna_reflex1.49515150
37MP0005646_abnormal_pituitary_gland1.49437218
38MP0009745_abnormal_behavioral_response1.47715402
39MP0002163_abnormal_gland_morphology1.47134995
40MP0001764_abnormal_homeostasis1.46959038
41MP0001486_abnormal_startle_reflex1.43633033
42MP0010094_abnormal_chromosome_stability1.41264226
43MP0001986_abnormal_taste_sensitivity1.40882762
44MP0002572_abnormal_emotion/affect_behav1.37135592
45MP0009046_muscle_twitch1.36192228
46MP0000778_abnormal_nervous_system1.32815212
47MP0002734_abnormal_mechanical_nocicepti1.31870058
48MP0008789_abnormal_olfactory_epithelium1.31141434
49MP0000015_abnormal_ear_pigmentation1.31020023
50MP0006035_abnormal_mitochondrial_morpho1.28729140
51MP0002064_seizures1.27836189
52MP0008877_abnormal_DNA_methylation1.27290075
53MP0002751_abnormal_autonomic_nervous1.27201081
54MP0002735_abnormal_chemical_nociception1.27108287
55MP0001440_abnormal_grooming_behavior1.26699293
56MP0003938_abnormal_ear_development1.24861008
57MP0006072_abnormal_retinal_apoptosis1.23708376
58MP0005408_hypopigmentation1.23515661
59MP0004133_heterotaxia1.23483673
60MP0003123_paternal_imprinting1.21744261
61MP0002019_abnormal_tumor_incidence1.20940527
62MP0005379_endocrine/exocrine_gland_phen1.20405926
63MP0001727_abnormal_embryo_implantation1.17861047
64MP0000049_abnormal_middle_ear1.17746332
65MP0000313_abnormal_cell_death1.17354488
66MP0000566_synostosis1.17105949
67MP0005174_abnormal_tail_pigmentation1.16444010
68MP0009278_abnormal_bone_marrow1.16219658
69MP0005671_abnormal_response_to1.15684316
70MP0003077_abnormal_cell_cycle1.15567769
71MP0003635_abnormal_synaptic_transmissio1.15460071
72MP0000026_abnormal_inner_ear1.15309684
73MP0000358_abnormal_cell_content/1.14665461
74MP0000490_abnormal_crypts_of1.14028352
75MP0001293_anophthalmia1.13447696
76MP0002067_abnormal_sensory_capabilities1.11880496
77MP0002234_abnormal_pharynx_morphology1.11396009
78MP0002095_abnormal_skin_pigmentation1.09932159
79MP0002184_abnormal_innervation1.09472873
80MP0001984_abnormal_olfaction1.09340546
81MP0005499_abnormal_olfactory_system1.09007227
82MP0005394_taste/olfaction_phenotype1.09007227
83MP0004742_abnormal_vestibular_system1.08515170
84MP0006036_abnormal_mitochondrial_physio1.06322274
85MP0008875_abnormal_xenobiotic_pharmacok1.03908087
86MP0001963_abnormal_hearing_physiology1.01899811
87MP0002396_abnormal_hematopoietic_system1.01341946
88MP0001970_abnormal_pain_threshold1.01314483
89MP0005397_hematopoietic_system_phenotyp1.00546653
90MP0001545_abnormal_hematopoietic_system1.00546653
91MP0004270_analgesia1.00530916
92MP0003122_maternal_imprinting0.99641264
93MP0001929_abnormal_gametogenesis0.99235679
94MP0000631_abnormal_neuroendocrine_gland0.99195318
95MP0002752_abnormal_somatic_nervous0.98341239
96MP0001145_abnormal_male_reproductive0.98012764
97MP0002277_abnormal_respiratory_mucosa0.97687004
98MP0004924_abnormal_behavior0.97153374
99MP0005386_behavior/neurological_phenoty0.97153374
100MP0001919_abnormal_reproductive_system0.97083771
101MP0001835_abnormal_antigen_presentation0.95833418
102MP0002148_abnormal_hypersensitivity_rea0.95513463
103MP0000350_abnormal_cell_proliferation0.95085111
104MP0004147_increased_porphyrin_level0.93871978
105MP0005645_abnormal_hypothalamus_physiol0.93428687
106MP0008995_early_reproductive_senescence0.93019489
107MP0005551_abnormal_eye_electrophysiolog0.92727689
108MP0003121_genomic_imprinting0.92693749
109MP0000653_abnormal_sex_gland0.92168447
110MP0002063_abnormal_learning/memory/cond0.91277219
111MP0002398_abnormal_bone_marrow0.88887587
112MP0005636_abnormal_mineral_homeostasis0.87463730
113MP0000689_abnormal_spleen_morphology0.87038130
114MP0002733_abnormal_thermal_nociception0.85798663
115MP0003111_abnormal_nucleus_morphology0.85747531
116MP0001881_abnormal_mammary_gland0.85180575
117MP0002722_abnormal_immune_system0.84017518
118MP0002557_abnormal_social/conspecific_i0.83891423
119MP0002429_abnormal_blood_cell0.82066146
120MP0001853_heart_inflammation0.82034368
121MP0005670_abnormal_white_adipose0.80734301
122MP0002132_abnormal_respiratory_system0.80550672
123MP0002876_abnormal_thyroid_physiology0.79992366
124MP0001119_abnormal_female_reproductive0.78949525
125MP0004145_abnormal_muscle_electrophysio0.78738205
126MP0005332_abnormal_amino_acid0.77431341
127MP0005220_abnormal_exocrine_pancreas0.76829735
128MP0008873_increased_physiological_sensi0.76547244
129MP0005410_abnormal_fertilization0.76496216
130MP0005253_abnormal_eye_physiology0.76090611
131MP0000703_abnormal_thymus_morphology0.75740102
132MP0002138_abnormal_hepatobiliary_system0.75429047
133MP0002160_abnormal_reproductive_system0.75190256
134MP0005389_reproductive_system_phenotype0.73991611
135MP0001501_abnormal_sleep_pattern0.73237681
136MP0003567_abnormal_fetal_cardiomyocyte0.72526796
137MP0005367_renal/urinary_system_phenotyp0.72260627
138MP0000516_abnormal_urinary_system0.72260627
139MP0003186_abnormal_redox_activity0.71521428
140MP0000716_abnormal_immune_system0.71329668
141MP0003646_muscle_fatigue0.70964119
142MP0002882_abnormal_neuron_morphology0.70890384
143MP0003698_abnormal_male_reproductive0.69761009
144MP0003787_abnormal_imprinting0.69599637
145MP0001730_embryonic_growth_arrest0.69324745
146MP0002177_abnormal_outer_ear0.69315110
147MP0002420_abnormal_adaptive_immunity0.68973544
148MP0001819_abnormal_immune_cell0.68655861
149MP0002837_dystrophic_cardiac_calcinosis0.68521330
150MP0002210_abnormal_sex_determination0.64710161
151MP0000920_abnormal_myelination0.64009119
152MP0003941_abnormal_skin_development0.63985870
153MP0008872_abnormal_physiological_respon0.63943062

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.86384426
2Mitochondrial inheritance (HP:0001427)5.34880764
3Abnormal mitochondria in muscle tissue (HP:0008316)5.10660859
4Abnormality of cells of the erythroid lineage (HP:0012130)5.06210040
5Increased hepatocellular lipid droplets (HP:0006565)5.01265868
6Progressive macrocephaly (HP:0004481)4.92384042
7Abnormal number of erythroid precursors (HP:0012131)4.56843977
8Increased CSF lactate (HP:0002490)4.50789515
9Acute encephalopathy (HP:0006846)4.50151695
10Renal Fanconi syndrome (HP:0001994)4.33747123
11Hepatocellular necrosis (HP:0001404)4.32552748
12Lipid accumulation in hepatocytes (HP:0006561)4.24206879
133-Methylglutaconic aciduria (HP:0003535)4.19932994
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.19001340
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.16468320
16Reticulocytopenia (HP:0001896)4.03111900
17Macrocytic anemia (HP:0001972)3.49306975
18Hepatic necrosis (HP:0002605)3.46202217
19Exertional dyspnea (HP:0002875)3.46015969
20Increased intramyocellular lipid droplets (HP:0012240)3.37828430
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.30699507
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.20118481
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.20118481
24Exercise intolerance (HP:0003546)3.19568421
25Parakeratosis (HP:0001036)3.19386827
26Abnormality of glycolysis (HP:0004366)3.17604282
27Increased serum pyruvate (HP:0003542)3.17604282
28Optic disc pallor (HP:0000543)3.14441102
29Increased serum lactate (HP:0002151)3.09303436
30Pallor (HP:0000980)3.02444395
31Respiratory difficulties (HP:0002880)2.94152557
32Leukodystrophy (HP:0002415)2.90554364
33Respiratory failure (HP:0002878)2.89121589
34Abnormality of renal resorption (HP:0011038)2.80472463
35Abnormal protein glycosylation (HP:0012346)2.78409092
36Abnormal glycosylation (HP:0012345)2.78409092
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.78409092
38Abnormal protein N-linked glycosylation (HP:0012347)2.78409092
39Methylmalonic aciduria (HP:0012120)2.76566466
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72913858
41Dicarboxylic aciduria (HP:0003215)2.72913858
42Lactic acidosis (HP:0003128)2.72065427
43Cerebral edema (HP:0002181)2.71209502
44Pancytopenia (HP:0001876)2.59801307
45Increased muscle lipid content (HP:0009058)2.55744369
46Lethargy (HP:0001254)2.50871766
47Methylmalonic acidemia (HP:0002912)2.49234643
48Testicular atrophy (HP:0000029)2.46188548
49Birth length less than 3rd percentile (HP:0003561)2.44381224
50Cerebral hypomyelination (HP:0006808)2.39101167
51Hyperglycinemia (HP:0002154)2.35334128
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30933189
53Breast hypoplasia (HP:0003187)2.28015929
54Medial flaring of the eyebrow (HP:0010747)2.27866119
55Colon cancer (HP:0003003)2.26785010
56Microretrognathia (HP:0000308)2.21669295
57Amniotic constriction ring (HP:0009775)2.20496272
58Abnormality of placental membranes (HP:0011409)2.20496272
59Abnormality of the axillary hair (HP:0100134)2.20217375
60Abnormality of secondary sexual hair (HP:0009888)2.20217375
61Congenital ichthyosiform erythroderma (HP:0007431)2.19346934
62Absent thumb (HP:0009777)2.18708451
63Cleft eyelid (HP:0000625)2.16851818
64Aplastic anemia (HP:0001915)2.16583528
65Progressive microcephaly (HP:0000253)2.12165926
66Type I transferrin isoform profile (HP:0003642)2.10836761
67Stenosis of the external auditory canal (HP:0000402)2.09085658
68Multiple enchondromatosis (HP:0005701)2.08937493
69Microvesicular hepatic steatosis (HP:0001414)2.05172707
70Rough bone trabeculation (HP:0100670)2.03960194
71Aplasia/hypoplasia of the uterus (HP:0008684)2.03251100
72Abnormal respiratory epithelium morphology (HP:0012253)2.01156630
73Abnormal respiratory motile cilium morphology (HP:0005938)2.01156630
74Pancreatic fibrosis (HP:0100732)2.00191857
75Reduced antithrombin III activity (HP:0001976)1.98757418
76Generalized aminoaciduria (HP:0002909)1.98412275
77Gait imbalance (HP:0002141)1.98208957
78True hermaphroditism (HP:0010459)1.97270809
79Congenital primary aphakia (HP:0007707)1.96085463
80Ragged-red muscle fibers (HP:0003200)1.95677714
81Oral leukoplakia (HP:0002745)1.94868961
82X-linked dominant inheritance (HP:0001423)1.94590066
83Congenital, generalized hypertrichosis (HP:0004540)1.93857950
84Opisthotonus (HP:0002179)1.89673149
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88421355
86Duplicated collecting system (HP:0000081)1.88368034
87Abnormal ciliary motility (HP:0012262)1.87155766
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86907400
89Nephrogenic diabetes insipidus (HP:0009806)1.86391684
90Pancreatic cysts (HP:0001737)1.86037135
91Molar tooth sign on MRI (HP:0002419)1.84970561
92Abnormality of midbrain morphology (HP:0002418)1.84970561
93Progressive external ophthalmoplegia (HP:0000590)1.84576194
94Progressive muscle weakness (HP:0003323)1.81063162
95Supernumerary spleens (HP:0009799)1.80589094
96Emotional lability (HP:0000712)1.80227977
97Hyperphosphaturia (HP:0003109)1.80170252
98Agammaglobulinemia (HP:0004432)1.79303031
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.78754850
100Premature graying of hair (HP:0002216)1.78740468
101Hypothermia (HP:0002045)1.77637077
102Degeneration of anterior horn cells (HP:0002398)1.77238974
103Abnormality of the anterior horn cell (HP:0006802)1.77238974
104Muscle fiber atrophy (HP:0100295)1.76863948
105Meckel diverticulum (HP:0002245)1.76759753
106Cerebral palsy (HP:0100021)1.73796931
107Triphalangeal thumb (HP:0001199)1.73088253
108Horseshoe kidney (HP:0000085)1.73039410
109IgM deficiency (HP:0002850)1.73020743
110Neutropenia (HP:0001875)1.71794021
111Delusions (HP:0000746)1.70522640
112CNS demyelination (HP:0007305)1.68851737
11311 pairs of ribs (HP:0000878)1.68257458
114Abnormality of the ileum (HP:0001549)1.67925770
115Vaginal atresia (HP:0000148)1.67454054
116Genital tract atresia (HP:0001827)1.67145001
117Abnormality of the preputium (HP:0100587)1.66806058
118Absent radius (HP:0003974)1.66425321
119Abnormal hair whorl (HP:0010721)1.66084634
120Gliosis (HP:0002171)1.65259226
121Abnormality of alanine metabolism (HP:0010916)1.64200273
122Hyperalaninemia (HP:0003348)1.64200273
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64200273
124Short tibia (HP:0005736)1.63537616
125Pendular nystagmus (HP:0012043)1.63446289
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.63308204
127Abnormality of urine glucose concentration (HP:0011016)1.62893962
128Glycosuria (HP:0003076)1.62893962
129Abnormality of serum amino acid levels (HP:0003112)1.62837002
130Renal tubular dysfunction (HP:0000124)1.62723221
131Cellular immunodeficiency (HP:0005374)1.62657101
132Aplasia involving forearm bones (HP:0009822)1.62157476
133Absent forearm bone (HP:0003953)1.62157476
134Asplenia (HP:0001746)1.62152226
135Duplication of thumb phalanx (HP:0009942)1.62115843
136Dynein arm defect of respiratory motile cilia (HP:0012255)1.61050840
137Absent/shortened dynein arms (HP:0200106)1.61050840
138Abnormal trabecular bone morphology (HP:0100671)1.61027128
139Limb dystonia (HP:0002451)1.60156427
140Severe visual impairment (HP:0001141)1.59967899
141Type 2 muscle fiber atrophy (HP:0003554)1.59342725
142Adrenal hypoplasia (HP:0000835)1.59152651
143Panhypogammaglobulinemia (HP:0003139)1.59102493
144Aplasia/Hypoplasia involving the musculature (HP:0001460)1.58938004
145Abnormality of the renal collecting system (HP:0004742)1.58268628
146Abnormal pupillary function (HP:0007686)1.58134099
147Sclerocornea (HP:0000647)1.57385220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.69494430
2STK163.88456808
3BCKDK3.58953505
4NME12.91412235
5BUB12.86133176
6SRPK12.66364092
7VRK12.65854348
8WEE12.50380082
9CASK2.48130916
10MAP3K122.40225907
11TNIK2.37133832
12PNCK2.36466776
13NME22.33805272
14NUAK12.19668659
15EIF2AK12.15441052
16MUSK1.98551029
17MST41.97145813
18MAP4K21.90535659
19TLK11.85434417
20MKNK11.77221698
21PBK1.73607764
22STK391.72742537
23CDK191.69291719
24EIF2AK31.56053798
25GRK71.54170805
26PLK41.50930605
27MAP2K71.49025682
28ARAF1.48592039
29MKNK21.43268842
30TESK11.43034687
31BCR1.41580598
32DYRK21.40258856
33OXSR11.39338009
34BMPR1B1.39252684
35MAP3K111.34289968
36TAOK31.30451580
37MAPKAPK51.28367936
38ADRBK21.26805095
39SCYL21.24519189
40MAPK131.24094328
41PIM21.22560691
42BMPR21.20841506
43ATR1.15150039
44MARK11.10853852
45TSSK61.10553165
46MAP4K11.08115519
47UHMK11.07838688
48GRK51.07520213
49CSNK1G31.02537630
50MYLK0.97324086
51YES10.95015654
52BRAF0.94738887
53NEK60.94262655
54TAF10.90304871
55NEK10.89632273
56CDC70.88462861
57TTK0.88413770
58AURKA0.87363531
59PLK30.84834611
60CAMK2B0.83546290
61PLK20.82970533
62EIF2AK20.80940782
63ZAK0.80519618
64RPS6KA50.79540939
65ABL20.79143573
66CDK80.78113690
67PLK10.76652224
68FGR0.73842723
69CCNB10.72310729
70FLT30.71839604
71CSNK2A10.68392765
72CSNK2A20.68295677
73KIT0.68228208
74EPHA40.66349515
75ILK0.65996184
76LRRK20.65711722
77PDK20.65566039
78NTRK30.64827107
79CAMK2A0.63978115
80DYRK30.63555915
81DAPK30.62958266
82CSNK1G10.61858143
83ADRBK10.60774861
84BRSK20.60393220
85INSRR0.60391307
86CDK30.60336251
87IKBKB0.59206749
88GRK10.58885924
89NEK20.57861044
90CDK70.57482670
91PASK0.56697962
92LIMK10.55610965
93AURKB0.55224299
94RPS6KA40.54464893
95IRAK40.52717007
96TXK0.52587736
97MAPKAPK30.52212559
98RPS6KB20.51640555
99PKN10.51216439
100TRIM280.51085376
101CSNK1G20.51052372
102PIM10.50252551
103TEC0.49644692
104OBSCN0.49292520
105CHEK10.49259687
106WNK40.49150200
107CDK40.48278895
108BRSK10.48050633
109IRAK20.47609239
110TNK20.46906536
111KDR0.46190792
112ACVR1B0.45427293
113CSNK1A1L0.45272342
114CLK10.44822761
115CAMK2D0.43582798
116DAPK10.43120238
117ROCK20.42794821
118STK40.42707491
119TIE10.42516707
120CHEK20.41581067
121CDK11A0.41394458
122PAK10.40824612
123ATM0.40467479
124MAP3K40.39643394
125CDK180.39434127
126PRKCI0.38954844
127PRKCG0.38594982
128RIPK40.38174880
129PRKACA0.38016094
130FES0.37611743
131MAPK40.37417246
132CDK150.36818114
133CDK140.36375086
134CAMK2G0.35210419
135WNK30.34670175
136TESK20.34557530
137SMG10.34268871
138GRK60.32605764
139PINK10.31826514
140CSNK1A10.31402808
141CDK20.30234477
142PRKCQ0.29896745
143MAP2K20.28905565

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.44724961
2Oxidative phosphorylation_Homo sapiens_hsa001904.85327907
3Proteasome_Homo sapiens_hsa030504.18661471
4Parkinsons disease_Homo sapiens_hsa050124.14528277
5RNA polymerase_Homo sapiens_hsa030203.90419848
6Huntingtons disease_Homo sapiens_hsa050163.22704462
7Alzheimers disease_Homo sapiens_hsa050103.15615508
8Protein export_Homo sapiens_hsa030602.67153717
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42367177
10DNA replication_Homo sapiens_hsa030302.36846434
11* Spliceosome_Homo sapiens_hsa030402.31000340
12Pyrimidine metabolism_Homo sapiens_hsa002402.24172995
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23258953
14Mismatch repair_Homo sapiens_hsa034302.22394083
15Homologous recombination_Homo sapiens_hsa034401.99158949
16Nucleotide excision repair_Homo sapiens_hsa034201.86785077
17Cardiac muscle contraction_Homo sapiens_hsa042601.82645790
18Basal transcription factors_Homo sapiens_hsa030221.74757564
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71518309
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55505827
21RNA transport_Homo sapiens_hsa030131.43789545
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41201950
23Nicotine addiction_Homo sapiens_hsa050331.40472272
24Fanconi anemia pathway_Homo sapiens_hsa034601.40311465
25Purine metabolism_Homo sapiens_hsa002301.38971360
26Non-homologous end-joining_Homo sapiens_hsa034501.35890125
27Base excision repair_Homo sapiens_hsa034101.34073411
28* RNA degradation_Homo sapiens_hsa030181.32098343
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28327360
30Collecting duct acid secretion_Homo sapiens_hsa049661.12367821
31Phototransduction_Homo sapiens_hsa047441.12170709
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11397034
33Fatty acid elongation_Homo sapiens_hsa000620.96384519
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93941991
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87146656
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86648952
37Pyruvate metabolism_Homo sapiens_hsa006200.85754715
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85536301
39Serotonergic synapse_Homo sapiens_hsa047260.84318388
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84119787
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83417024
42Peroxisome_Homo sapiens_hsa041460.82428792
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80964260
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.78594384
45Ether lipid metabolism_Homo sapiens_hsa005650.77595940
46Arachidonic acid metabolism_Homo sapiens_hsa005900.77259442
47Steroid biosynthesis_Homo sapiens_hsa001000.75326224
48Biosynthesis of amino acids_Homo sapiens_hsa012300.75149971
49Sulfur metabolism_Homo sapiens_hsa009200.73501278
50Cell cycle_Homo sapiens_hsa041100.72253437
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69623765
52Selenocompound metabolism_Homo sapiens_hsa004500.69049694
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69002358
54Carbon metabolism_Homo sapiens_hsa012000.68196812
55Propanoate metabolism_Homo sapiens_hsa006400.67308567
56Metabolic pathways_Homo sapiens_hsa011000.67296217
57Epstein-Barr virus infection_Homo sapiens_hsa051690.64944475
58Vibrio cholerae infection_Homo sapiens_hsa051100.64414600
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.63786140
60Antigen processing and presentation_Homo sapiens_hsa046120.62154518
61mRNA surveillance pathway_Homo sapiens_hsa030150.60215990
62Pentose phosphate pathway_Homo sapiens_hsa000300.56314675
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.54774085
64Glutathione metabolism_Homo sapiens_hsa004800.54703244
65Linoleic acid metabolism_Homo sapiens_hsa005910.53757014
66Butanoate metabolism_Homo sapiens_hsa006500.53382898
67Systemic lupus erythematosus_Homo sapiens_hsa053220.53030290
68Taste transduction_Homo sapiens_hsa047420.52591438
69Sphingolipid metabolism_Homo sapiens_hsa006000.49984264
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49466358
71Alcoholism_Homo sapiens_hsa050340.47704723
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46128405
73Rheumatoid arthritis_Homo sapiens_hsa053230.45959471
74Glutamatergic synapse_Homo sapiens_hsa047240.45161185
75Autoimmune thyroid disease_Homo sapiens_hsa053200.43086826
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42789694
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42002292
78Asthma_Homo sapiens_hsa053100.40122770
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39816820
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38829355
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37944197
82GABAergic synapse_Homo sapiens_hsa047270.36674264
83Oocyte meiosis_Homo sapiens_hsa041140.35568059
84Morphine addiction_Homo sapiens_hsa050320.35350236
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34776773
86One carbon pool by folate_Homo sapiens_hsa006700.34288727
87Long-term depression_Homo sapiens_hsa047300.33591259
88Chemical carcinogenesis_Homo sapiens_hsa052040.32494885
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31603972
90Vitamin digestion and absorption_Homo sapiens_hsa049770.31130769
91Allograft rejection_Homo sapiens_hsa053300.30800517
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30671486
93Synaptic vesicle cycle_Homo sapiens_hsa047210.29476977
94Tryptophan metabolism_Homo sapiens_hsa003800.29333137
95Folate biosynthesis_Homo sapiens_hsa007900.29254274
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.29000476
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28978246
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26694526
99Herpes simplex infection_Homo sapiens_hsa051680.26667658
100Caffeine metabolism_Homo sapiens_hsa002320.25917695
101p53 signaling pathway_Homo sapiens_hsa041150.25805437
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25782861
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25543412
104Fatty acid metabolism_Homo sapiens_hsa012120.25260985
105Amphetamine addiction_Homo sapiens_hsa050310.23632580
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23160620
107Fructose and mannose metabolism_Homo sapiens_hsa000510.23145281
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22640196
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22126600
110Dopaminergic synapse_Homo sapiens_hsa047280.21677298
111Nitrogen metabolism_Homo sapiens_hsa009100.20968541
112Tyrosine metabolism_Homo sapiens_hsa003500.20271731
113Graft-versus-host disease_Homo sapiens_hsa053320.19987911
114Axon guidance_Homo sapiens_hsa043600.19026184
115Calcium signaling pathway_Homo sapiens_hsa040200.17968362
116Regulation of autophagy_Homo sapiens_hsa041400.16250504
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.14729593
118Phagosome_Homo sapiens_hsa041450.13507848
119Circadian entrainment_Homo sapiens_hsa047130.12313944
120Primary immunodeficiency_Homo sapiens_hsa053400.09984752
121African trypanosomiasis_Homo sapiens_hsa051430.07962085
122Hematopoietic cell lineage_Homo sapiens_hsa046400.07768077
123Vitamin B6 metabolism_Homo sapiens_hsa007500.06974634
124Cocaine addiction_Homo sapiens_hsa050300.06367962
125Wnt signaling pathway_Homo sapiens_hsa043100.06310356
126N-Glycan biosynthesis_Homo sapiens_hsa005100.06064232
127Sulfur relay system_Homo sapiens_hsa041220.05692045
128Arginine and proline metabolism_Homo sapiens_hsa003300.05274380
129Hedgehog signaling pathway_Homo sapiens_hsa043400.05203905
130Phenylalanine metabolism_Homo sapiens_hsa003600.04956933
131Type I diabetes mellitus_Homo sapiens_hsa049400.04516372
132Long-term potentiation_Homo sapiens_hsa047200.04447989
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03849022

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