LSM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.79776869
2ribosomal small subunit biogenesis (GO:0042274)5.72837896
3viral transcription (GO:0019083)5.47769656
4translational termination (GO:0006415)5.32369036
5maturation of SSU-rRNA (GO:0030490)5.27548266
6DNA deamination (GO:0045006)4.93675393
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.85023908
8cotranslational protein targeting to membrane (GO:0006613)4.83376069
9protein targeting to ER (GO:0045047)4.75457581
10translational elongation (GO:0006414)4.54623921
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.53512638
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52748915
13telomere maintenance via semi-conservative replication (GO:0032201)4.51858437
14protein localization to endoplasmic reticulum (GO:0070972)4.49916751
15proteasome assembly (GO:0043248)4.49200634
16ribosomal large subunit biogenesis (GO:0042273)4.36363722
17DNA strand elongation involved in DNA replication (GO:0006271)4.31866762
18ATP synthesis coupled proton transport (GO:0015986)4.27359282
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27359282
20translational initiation (GO:0006413)4.23464867
21cellular protein complex disassembly (GO:0043624)4.21948638
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.20853950
23viral life cycle (GO:0019058)4.19694581
24DNA strand elongation (GO:0022616)4.12619951
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.05503088
26termination of RNA polymerase III transcription (GO:0006386)4.05503088
27CENP-A containing nucleosome assembly (GO:0034080)4.04563107
28telomere maintenance via recombination (GO:0000722)4.03469512
29establishment of integrated proviral latency (GO:0075713)3.97582725
30DNA replication initiation (GO:0006270)3.93851984
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.90956247
32ribonucleoprotein complex biogenesis (GO:0022613)3.86827781
33chromatin remodeling at centromere (GO:0031055)3.84404250
34protein complex biogenesis (GO:0070271)3.83290474
35respiratory electron transport chain (GO:0022904)3.82133444
36translation (GO:0006412)3.81963706
37mitochondrial respiratory chain complex assembly (GO:0033108)3.78527086
38electron transport chain (GO:0022900)3.77168683
39mitotic recombination (GO:0006312)3.75893638
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74052771
41DNA replication checkpoint (GO:0000076)3.72761672
427-methylguanosine mRNA capping (GO:0006370)3.70983143
43RNA capping (GO:0036260)3.68017641
447-methylguanosine RNA capping (GO:0009452)3.68017641
45protein complex disassembly (GO:0043241)3.65102121
46spliceosomal snRNP assembly (GO:0000387)3.61384018
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.60571428
48transcription-coupled nucleotide-excision repair (GO:0006283)3.56544109
49rRNA processing (GO:0006364)3.52248417
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51857225
51macromolecular complex disassembly (GO:0032984)3.51268203
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49789451
53DNA replication-independent nucleosome assembly (GO:0006336)3.47700669
54DNA replication-independent nucleosome organization (GO:0034724)3.47700669
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45731231
56formation of translation preinitiation complex (GO:0001731)3.45014093
57telomere maintenance via telomere lengthening (GO:0010833)3.44306048
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43932499
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43733603
60nucleobase biosynthetic process (GO:0046112)3.42138274
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41873905
62negative regulation of ligase activity (GO:0051352)3.41873905
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41149961
64regulation of mitotic spindle checkpoint (GO:1903504)3.41149961
65kinetochore organization (GO:0051383)3.40208525
66spliceosomal complex assembly (GO:0000245)3.39050053
67rRNA metabolic process (GO:0016072)3.38724732
68nuclear-transcribed mRNA catabolic process (GO:0000956)3.37119967
69respiratory chain complex IV assembly (GO:0008535)3.36977261
70cellular component biogenesis (GO:0044085)3.36057316
71rRNA modification (GO:0000154)3.35688913
72meiotic chromosome segregation (GO:0045132)3.35632797
73GTP biosynthetic process (GO:0006183)3.35541170
74replication fork processing (GO:0031297)3.31608605
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.30213556
76pseudouridine synthesis (GO:0001522)3.27882065
77resolution of meiotic recombination intermediates (GO:0000712)3.25608094
78kinetochore assembly (GO:0051382)3.25575652
79DNA double-strand break processing (GO:0000729)3.25375730
80establishment of viral latency (GO:0019043)3.24408522
81transcription elongation from RNA polymerase I promoter (GO:0006362)3.22787214
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22567209
83termination of RNA polymerase I transcription (GO:0006363)3.19541646
84protein neddylation (GO:0045116)3.18757931
85mRNA catabolic process (GO:0006402)3.18364617
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17561479
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17561479
88regulation of cellular amino acid metabolic process (GO:0006521)3.17450009
89deoxyribonucleotide biosynthetic process (GO:0009263)3.17047878
90histone mRNA metabolic process (GO:0008334)3.16729734
91protein K6-linked ubiquitination (GO:0085020)3.16569104
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16138011
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16138011
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16138011
95cullin deneddylation (GO:0010388)3.15433909
96centriole replication (GO:0007099)3.15376085
97chaperone-mediated protein transport (GO:0072321)3.13167688
98histone exchange (GO:0043486)3.09976546
99negative regulation of DNA-dependent DNA replication (GO:2000104)3.09963334
100cytochrome complex assembly (GO:0017004)3.08848055
101protein-cofactor linkage (GO:0018065)3.08155805
102UTP biosynthetic process (GO:0006228)3.07911704
103DNA damage response, detection of DNA damage (GO:0042769)3.06913707
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.06324464
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06324464
106protein targeting to membrane (GO:0006612)3.06009597
107mitochondrial respiratory chain complex I assembly (GO:0032981)3.05341567
108NADH dehydrogenase complex assembly (GO:0010257)3.05341567
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05341567
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04979477
111signal transduction involved in cell cycle checkpoint (GO:0072395)3.04583219
112mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02633210
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.02065676
114cell cycle G1/S phase transition (GO:0044843)3.01808267
115G1/S transition of mitotic cell cycle (GO:0000082)3.01808267
116recombinational repair (GO:0000725)3.01797775
117guanosine-containing compound biosynthetic process (GO:1901070)3.01429550
118double-strand break repair via homologous recombination (GO:0000724)3.01293743
119DNA unwinding involved in DNA replication (GO:0006268)2.99384656
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99003213
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97019570
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97019570
123DNA catabolic process, exonucleolytic (GO:0000738)2.95871520
124synapsis (GO:0007129)2.80894806
125somatic hypermutation of immunoglobulin genes (GO:0016446)2.79714875
126somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79714875
127purine nucleobase biosynthetic process (GO:0009113)2.79129677
128regulation of mitochondrial translation (GO:0070129)2.78484129
129maturation of 5.8S rRNA (GO:0000460)2.78297567
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75589317
131RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72633296
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.71234616
133protein localization to kinetochore (GO:0034501)2.70975143
134tRNA processing (GO:0008033)2.69584184
135RNA catabolic process (GO:0006401)2.69350104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.51337551
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.50570534
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.44632703
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.33999254
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.10784261
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06058762
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55453485
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53691641
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.45818125
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32215676
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31723283
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21269903
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20560879
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.03140198
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96293243
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88313397
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86329984
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82412387
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82117732
20VDR_23849224_ChIP-Seq_CD4+_Human2.78009959
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76338407
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72365822
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68858420
24ELK1_19687146_ChIP-ChIP_HELA_Human2.43954432
25XRN2_22483619_ChIP-Seq_HELA_Human2.42057933
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.36384130
27DCP1A_22483619_ChIP-Seq_HELA_Human2.31761357
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24527832
29ZNF274_21170338_ChIP-Seq_K562_Hela2.20060809
30TTF2_22483619_ChIP-Seq_HELA_Human2.19631826
31FOXP3_21729870_ChIP-Seq_TREG_Human2.18043162
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12350429
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10832712
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06058512
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04922647
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01140888
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.99882913
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94823828
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.94526631
40GABP_19822575_ChIP-Seq_HepG2_Human1.90126844
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87962568
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.87318592
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87156262
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86971648
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77728405
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75558282
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73704102
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69497384
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68757546
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62358439
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59549279
52AR_21909140_ChIP-Seq_LNCAP_Human1.56325188
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.53379115
54IGF1R_20145208_ChIP-Seq_DFB_Human1.50955249
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49901849
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49307580
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46596278
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44567641
59MYC_18940864_ChIP-ChIP_HL60_Human1.43750267
60* ELK1_22589737_ChIP-Seq_MCF10A_Human1.39053503
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.31743630
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30779369
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30084773
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29709119
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27814804
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27470418
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26510567
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25282141
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24622097
70CIITA_25753668_ChIP-Seq_RAJI_Human1.24620408
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21864844
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21720545
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21535580
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20112239
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19669797
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13819952
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13513539
78IRF1_19129219_ChIP-ChIP_H3396_Human1.11936183
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10653160
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09563733
81TAF15_26573619_Chip-Seq_HEK293_Human1.06077185
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05663178
83P300_19829295_ChIP-Seq_ESCs_Human1.05513067
84TP53_22573176_ChIP-Seq_HFKS_Human1.04693995
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03905435
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00951005
87KDM5A_27292631_Chip-Seq_BREAST_Human1.00673395
88ER_23166858_ChIP-Seq_MCF-7_Human1.00400992
89EWS_26573619_Chip-Seq_HEK293_Human0.98813786
90FUS_26573619_Chip-Seq_HEK293_Human0.96946981
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96760314
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.95612761
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95477161
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.94682094
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.93322545
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93322545
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92864394
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92492821
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92382599
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92200156
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.91317803
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91275257
103SOX2_19829295_ChIP-Seq_ESCs_Human0.91144622
104NANOG_19829295_ChIP-Seq_ESCs_Human0.91144622
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89607462
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89554043
107SPI1_23547873_ChIP-Seq_NB4_Human0.89047451
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88524772
109CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88328260
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86265839
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82402019
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80959000
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76605797
114VDR_22108803_ChIP-Seq_LS180_Human0.76431067
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.73877332
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.72740842
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.67500413
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67106401
119TFEB_21752829_ChIP-Seq_HELA_Human0.65199658
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.64981592
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.64604842
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.63680228
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.62617912
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62096698
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.62055247
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.60565780
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.58602583
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.57502202
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.56592913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.40622217
2MP0009379_abnormal_foot_pigmentation4.30190447
3MP0008057_abnormal_DNA_replication3.80647178
4MP0004957_abnormal_blastocyst_morpholog3.78270468
5MP0010094_abnormal_chromosome_stability3.73991270
6MP0008058_abnormal_DNA_repair3.38429572
7MP0003111_abnormal_nucleus_morphology3.07443852
8MP0003077_abnormal_cell_cycle2.95338709
9MP0003880_abnormal_central_pattern2.85141945
10MP0006292_abnormal_olfactory_placode2.81491243
11MP0008932_abnormal_embryonic_tissue2.65706817
12MP0008877_abnormal_DNA_methylation2.46520116
13MP0008007_abnormal_cellular_replicative2.28087267
14MP0008995_early_reproductive_senescence2.20745166
15MP0001529_abnormal_vocalization2.11354642
16MP0001188_hyperpigmentation2.05000118
17MP0003786_premature_aging2.04632688
18MP0003806_abnormal_nucleotide_metabolis1.99773986
19MP0003195_calcinosis1.97948732
20MP0002396_abnormal_hematopoietic_system1.90432288
21MP0003136_yellow_coat_color1.88600569
22MP0002102_abnormal_ear_morphology1.82836388
23MP0005409_darkened_coat_color1.81008410
24MP0005408_hypopigmentation1.70274106
25MP0002938_white_spotting1.61386156
26MP0004142_abnormal_muscle_tone1.58282368
27MP0003123_paternal_imprinting1.57835994
28MP0003315_abnormal_perineum_morphology1.57532469
29MP0002163_abnormal_gland_morphology1.51901758
30MP0001905_abnormal_dopamine_level1.48063918
31MP0002095_abnormal_skin_pigmentation1.47032652
32MP0002837_dystrophic_cardiac_calcinosis1.46447189
33MP0008789_abnormal_olfactory_epithelium1.46259275
34MP0005253_abnormal_eye_physiology1.41063003
35MP0000490_abnormal_crypts_of1.38830381
36MP0000372_irregular_coat_pigmentation1.38540930
37MP0008872_abnormal_physiological_respon1.37408187
38MP0005174_abnormal_tail_pigmentation1.37074277
39MP0003646_muscle_fatigue1.31127035
40MP0003718_maternal_effect1.28171810
41MP0003941_abnormal_skin_development1.24890868
42MP0000350_abnormal_cell_proliferation1.19968224
43MP0005084_abnormal_gallbladder_morpholo1.19255914
44MP0002132_abnormal_respiratory_system1.19058733
45MP0003890_abnormal_embryonic-extraembry1.15811572
46MP0005551_abnormal_eye_electrophysiolog1.15334446
47MP0005645_abnormal_hypothalamus_physiol1.15090369
48MP0001730_embryonic_growth_arrest1.13749288
49MP0002210_abnormal_sex_determination1.12485680
50MP0009333_abnormal_splenocyte_physiolog1.10263858
51MP0003763_abnormal_thymus_physiology1.08174906
52MP0000015_abnormal_ear_pigmentation1.06106201
53MP0002638_abnormal_pupillary_reflex1.04314291
54MP0003938_abnormal_ear_development1.04236070
55MP0004133_heterotaxia1.03414179
56MP0005499_abnormal_olfactory_system1.03122198
57MP0005394_taste/olfaction_phenotype1.03122198
58MP0004381_abnormal_hair_follicle1.03026293
59MP0000313_abnormal_cell_death1.02210213
60MP0000703_abnormal_thymus_morphology0.99473495
61MP0003121_genomic_imprinting0.98842765
62MP0001986_abnormal_taste_sensitivity0.97695578
63MP0000049_abnormal_middle_ear0.96604625
64MP0001145_abnormal_male_reproductive0.96052445
65MP0002160_abnormal_reproductive_system0.95318265
66MP0001873_stomach_inflammation0.94888664
67MP0003186_abnormal_redox_activity0.94651960
68MP0008875_abnormal_xenobiotic_pharmacok0.93099118
69MP0005075_abnormal_melanosome_morpholog0.91738453
70MP0001764_abnormal_homeostasis0.91519490
71MP0005379_endocrine/exocrine_gland_phen0.91109214
72MP0001929_abnormal_gametogenesis0.89960486
73MP0000569_abnormal_digit_pigmentation0.89463082
74MP0001697_abnormal_embryo_size0.89213947
75MP0005671_abnormal_response_to0.89076321
76MP0002398_abnormal_bone_marrow0.88364014
77MP0003567_abnormal_fetal_cardiomyocyte0.87530166
78MP0001800_abnormal_humoral_immune0.87400005
79MP0001119_abnormal_female_reproductive0.87193569
80MP0002019_abnormal_tumor_incidence0.86847731
81MP0005389_reproductive_system_phenotype0.86842263
82MP0006036_abnormal_mitochondrial_physio0.86402425
83MP0001293_anophthalmia0.84536702
84MP0002751_abnormal_autonomic_nervous0.83780127
85MP0000653_abnormal_sex_gland0.83553723
86MP0004147_increased_porphyrin_level0.83398647
87MP0001485_abnormal_pinna_reflex0.82509791
88MP0005171_absent_coat_pigmentation0.82451136
89MP0004808_abnormal_hematopoietic_stem0.81288838
90MP0001853_heart_inflammation0.81254161
91MP0002080_prenatal_lethality0.80764360
92MP0001919_abnormal_reproductive_system0.80453055
93MP0002722_abnormal_immune_system0.79917946
94MP0006072_abnormal_retinal_apoptosis0.79418067
95MP0010307_abnormal_tumor_latency0.78822383
96MP0005410_abnormal_fertilization0.78433920
97MP0006276_abnormal_autonomic_nervous0.78361379
98MP0006035_abnormal_mitochondrial_morpho0.78159645
99MP0002148_abnormal_hypersensitivity_rea0.78009713
100MP0006054_spinal_hemorrhage0.75558734
101MP0001286_abnormal_eye_development0.75179188
102MP0002009_preneoplasia0.74853433
103MP0002277_abnormal_respiratory_mucosa0.74236435
104MP0000689_abnormal_spleen_morphology0.73826485
105MP0003011_delayed_dark_adaptation0.73785131
106MP0002928_abnormal_bile_duct0.73600437
107MP0000465_gastrointestinal_hemorrhage0.71874756
108MP0002876_abnormal_thyroid_physiology0.71337301
109MP0002085_abnormal_embryonic_tissue0.70651860
110MP0005395_other_phenotype0.70312194
111MP0002429_abnormal_blood_cell0.69109515
112MP0005646_abnormal_pituitary_gland0.68903063
113MP0000631_abnormal_neuroendocrine_gland0.68511643
114MP0000427_abnormal_hair_cycle0.67760168
115MP0001324_abnormal_eye_pigmentation0.67491556
116MP0009785_altered_susceptibility_to0.66948006
117MP0005391_vision/eye_phenotype0.66497874
118MP0000716_abnormal_immune_system0.66430074
119MP0005195_abnormal_posterior_eye0.65808472
120MP0000566_synostosis0.64739007
121MP0003787_abnormal_imprinting0.64447270
122MP0000371_diluted_coat_color0.64295602
123MP0006082_CNS_inflammation0.63412558
124MP0001727_abnormal_embryo_implantation0.63011499
125MP0002177_abnormal_outer_ear0.62784553
126MP0002234_abnormal_pharynx_morphology0.62610200
127MP0000647_abnormal_sebaceous_gland0.61769989
128MP0005636_abnormal_mineral_homeostasis0.61549564
129MP0002420_abnormal_adaptive_immunity0.61427775
130MP0009697_abnormal_copulation0.60450174
131MP0001819_abnormal_immune_cell0.59947832
132MP0003937_abnormal_limbs/digits/tail_de0.59681594
133MP0002736_abnormal_nociception_after0.56890880
134MP0001672_abnormal_embryogenesis/_devel0.56708961
135MP0005380_embryogenesis_phenotype0.56708961
136MP0003698_abnormal_male_reproductive0.56000144

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.77489573
2Abnormal number of erythroid precursors (HP:0012131)5.53400226
3Reticulocytopenia (HP:0001896)4.98640781
4Acute necrotizing encephalopathy (HP:0006965)4.33663053
5Macrocytic anemia (HP:0001972)3.99527832
6Birth length less than 3rd percentile (HP:0003561)3.98315776
7Mitochondrial inheritance (HP:0001427)3.96591630
8Abnormal mitochondria in muscle tissue (HP:0008316)3.81331594
9Increased hepatocellular lipid droplets (HP:0006565)3.75377234
10Pallor (HP:0000980)3.52831506
11Progressive macrocephaly (HP:0004481)3.44171917
12Increased CSF lactate (HP:0002490)3.39035737
133-Methylglutaconic aciduria (HP:0003535)3.37656087
14Hepatocellular necrosis (HP:0001404)3.34475525
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21469634
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.20865411
17Breast hypoplasia (HP:0003187)3.12741846
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.10935589
19Lipid accumulation in hepatocytes (HP:0006561)3.09083798
20Acute encephalopathy (HP:0006846)3.08256723
21Aplastic anemia (HP:0001915)3.03261157
22Renal Fanconi syndrome (HP:0001994)2.96978550
23Colon cancer (HP:0003003)2.96871201
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93655958
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93655958
26Type I transferrin isoform profile (HP:0003642)2.89108298
27Exertional dyspnea (HP:0002875)2.87445348
28Abnormality of midbrain morphology (HP:0002418)2.78266501
29Molar tooth sign on MRI (HP:0002419)2.78266501
30Cerebral edema (HP:0002181)2.74909793
31Increased serum lactate (HP:0002151)2.74540188
32Abnormality of the heme biosynthetic pathway (HP:0010472)2.68668700
33Hepatic necrosis (HP:0002605)2.67485255
34Oral leukoplakia (HP:0002745)2.63511031
35Chromsome breakage (HP:0040012)2.60988314
36Abnormality of the preputium (HP:0100587)2.55824136
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53194427
38Abnormality of glycolysis (HP:0004366)2.49636486
39Increased serum pyruvate (HP:0003542)2.49636486
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45480896
41Exercise intolerance (HP:0003546)2.44939929
42Cerebral hypomyelination (HP:0006808)2.42931477
43Respiratory difficulties (HP:0002880)2.42351665
44Increased intramyocellular lipid droplets (HP:0012240)2.37230578
45Abnormality of the pons (HP:0007361)2.36502060
46Optic disc pallor (HP:0000543)2.31709704
47Rough bone trabeculation (HP:0100670)2.31232996
48Hypoplasia of the pons (HP:0012110)2.29690584
49Clubbing of toes (HP:0100760)2.28308741
50Meckel diverticulum (HP:0002245)2.28173524
51Absent thumb (HP:0009777)2.25839387
52Triphalangeal thumb (HP:0001199)2.24007341
53Patellar aplasia (HP:0006443)2.23923181
54Methylmalonic acidemia (HP:0002912)2.22261828
55Cleft eyelid (HP:0000625)2.21091477
56Microvesicular hepatic steatosis (HP:0001414)2.20944749
57Abnormal lung lobation (HP:0002101)2.18863113
58Abnormality of the ileum (HP:0001549)2.18742229
5911 pairs of ribs (HP:0000878)2.16778457
60Abnormality of the anterior horn cell (HP:0006802)2.16546753
61Degeneration of anterior horn cells (HP:0002398)2.16546753
62Megaloblastic anemia (HP:0001889)2.14988350
63Nephronophthisis (HP:0000090)2.14291524
64Duplicated collecting system (HP:0000081)2.13587637
65Leukodystrophy (HP:0002415)2.10109790
66B lymphocytopenia (HP:0010976)2.09895578
67Severe combined immunodeficiency (HP:0004430)2.09825330
68Microretrognathia (HP:0000308)2.09732652
69Aplasia/Hypoplasia of the patella (HP:0006498)2.09264544
70Abnormality of B cell number (HP:0010975)2.09155264
71Respiratory failure (HP:0002878)2.08862653
72Premature graying of hair (HP:0002216)2.08749203
73Lactic acidosis (HP:0003128)2.08095813
74Congenital stationary night blindness (HP:0007642)2.07990381
75Abnormality of the duodenum (HP:0002246)2.07656477
76Abnormality of chromosome stability (HP:0003220)2.03722628
77Homocystinuria (HP:0002156)2.03702469
78Abnormality of homocysteine metabolism (HP:0010919)2.03702469
79Sloping forehead (HP:0000340)2.03403202
80Pancytopenia (HP:0001876)2.01715709
81Abnormality of the renal collecting system (HP:0004742)2.01215329
82Abnormal protein glycosylation (HP:0012346)2.00094245
83Abnormal glycosylation (HP:0012345)2.00094245
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00094245
85Abnormal protein N-linked glycosylation (HP:0012347)2.00094245
86Horseshoe kidney (HP:0000085)1.98460131
87Medial flaring of the eyebrow (HP:0010747)1.97583136
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.97335059
89True hermaphroditism (HP:0010459)1.96716831
90Absent radius (HP:0003974)1.96456952
91Myelodysplasia (HP:0002863)1.96408572
92Pancreatic cysts (HP:0001737)1.95388906
93Abnormality of the labia minora (HP:0012880)1.95240917
94Abnormality of the axillary hair (HP:0100134)1.92918805
95Abnormality of secondary sexual hair (HP:0009888)1.92918805
96Congenital, generalized hypertrichosis (HP:0004540)1.92629435
97Pancreatic fibrosis (HP:0100732)1.91706461
98Lethargy (HP:0001254)1.88500070
99Agnosia (HP:0010524)1.88002211
100Abnormality of alanine metabolism (HP:0010916)1.86349324
101Hyperalaninemia (HP:0003348)1.86349324
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86349324
103Parakeratosis (HP:0001036)1.86297033
104Aplasia involving forearm bones (HP:0009822)1.84744201
105Absent forearm bone (HP:0003953)1.84744201
106Combined immunodeficiency (HP:0005387)1.84658559
107Small intestinal stenosis (HP:0012848)1.83508034
108Duodenal stenosis (HP:0100867)1.83508034
109Abnormality of methionine metabolism (HP:0010901)1.81977911
110Abnormality of renal resorption (HP:0011038)1.81958644
111Abnormality of the renal cortex (HP:0011035)1.81064197
112Abnormality of the renal medulla (HP:0100957)1.81003209
113Bone marrow hypocellularity (HP:0005528)1.80876018
114Abnormality of the carotid arteries (HP:0005344)1.79321538
115Type 2 muscle fiber atrophy (HP:0003554)1.78180291
116Muscle fiber atrophy (HP:0100295)1.77707019
117Depressed nasal ridge (HP:0000457)1.76892757
118Hypoproteinemia (HP:0003075)1.76492999
119Cellular immunodeficiency (HP:0005374)1.75997242
120Methylmalonic aciduria (HP:0012120)1.75986840
121Abnormality of serum amino acid levels (HP:0003112)1.75262027
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74051593
123Volvulus (HP:0002580)1.73094901
124Single umbilical artery (HP:0001195)1.72956294
125Abnormality of the fetal cardiovascular system (HP:0010948)1.72956294
126Abnormal umbilical cord blood vessels (HP:0011403)1.72956294
127Anencephaly (HP:0002323)1.72851050
128Abnormality of DNA repair (HP:0003254)1.71791146
129Hypothermia (HP:0002045)1.71369172
130Abnormality of the fovea (HP:0000493)1.70209782
131Attenuation of retinal blood vessels (HP:0007843)1.70146956
132Abnormal trabecular bone morphology (HP:0100671)1.70026909
133Panhypogammaglobulinemia (HP:0003139)1.69248284
134Ectopic kidney (HP:0000086)1.69080011
135Aplasia/Hypoplasia of the fovea (HP:0008060)1.68755698
136Hypoplasia of the fovea (HP:0007750)1.68755698
137Sclerocornea (HP:0000647)1.68619228
138Supernumerary spleens (HP:0009799)1.67801103
139Secondary amenorrhea (HP:0000869)1.67567552
140Reduced antithrombin III activity (HP:0001976)1.67176498
141Increased muscle lipid content (HP:0009058)1.67059706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.33268760
2WEE13.79065174
3STK163.60492746
4NME23.19965279
5CDC72.87404584
6FRK2.83352757
7VRK12.74013575
8VRK22.69804545
9EIF2AK12.66692816
10SRPK12.58345859
11PLK42.21178081
12EIF2AK32.12375090
13ACVR1B2.02201030
14MKNK12.01511535
15TLK11.99129096
16NEK11.97341079
17WNK31.81631115
18NME11.77419225
19MKNK21.67907429
20BRSK21.64921436
21CCNB11.64788874
22DYRK31.63325484
23TSSK61.60930944
24CDK191.52017762
25MAP4K21.49906886
26MAP3K121.48506046
27PLK11.44498205
28PLK31.43492411
29PBK1.42868586
30TNIK1.39229165
31TAOK31.38429260
32MST41.36724693
33CASK1.35170849
34PIM21.33526967
35PNCK1.30101717
36RIPK41.29138116
37GRK11.28840126
38WNK41.27432697
39TTK1.25781358
40AURKB1.23820987
41INSRR1.18554649
42CDK81.14420387
43AURKA1.14136605
44CDK71.14014534
45NEK21.11363599
46TAF11.09506644
47MAP2K71.08388633
48BRAF1.07568378
49EIF2AK21.07515031
50BMPR21.07109233
51ZAK1.07044210
52EPHA41.05247321
53TESK21.04766313
54ATR1.01706317
55ITK1.01635193
56CHEK20.99872167
57PASK0.99679113
58PDK20.95560900
59CLK10.95454573
60STK390.94512359
61BRSK10.92835248
62YES10.92272306
63OXSR10.88863600
64TRIM280.88448215
65IRAK40.87122394
66PLK20.84233935
67GRK70.83132741
68ARAF0.82286831
69STK30.80901886
70DYRK20.80878185
71DAPK10.80056284
72BCR0.79890965
73GRK60.79588023
74BMPR1B0.78461415
75BCKDK0.73761962
76CSNK2A10.73649410
77RPS6KA50.73341513
78TEC0.72918478
79RPS6KA40.72562752
80CSNK1G30.70477006
81ADRBK20.68163542
82CSNK2A20.68001879
83MYLK0.66925951
84ERBB30.66091514
85IRAK30.65951480
86KDR0.64548770
87CDK30.60309458
88ABL20.60285245
89MAPK130.60169840
90MUSK0.60079446
91MAP3K40.57985191
92CHEK10.53687294
93TGFBR10.53579290
94IKBKB0.53427004
95PRKCI0.52606331
96MARK30.51865748
97TXK0.51291958
98RPS6KB20.50617641
99CAMK2B0.50592750
100STK40.44201875
101LYN0.43803869
102SYK0.43715353
103MELK0.43547262
104PIM10.42562249
105PAK10.42149530
106STK38L0.41471684
107CSNK1G10.41401855
108MAP3K80.41011485
109ATM0.40507301
110KIT0.40372365
111PINK10.40250630
112PRKCG0.39740437
113BLK0.38712693
114ADRBK10.38001595
115PAK40.37108518
116CSNK1A10.36972246
117NLK0.36834448
118CDK40.35041800
119PRKCE0.35040315
120PRKCQ0.34712410
121CDK20.34688757
122IRAK20.33873096
123AKT30.33815424
124CDK10.33671716
125MAPKAPK50.33201816
126IRAK10.32276369
127NUAK10.32252152
128MAPK150.32111934
129RAF10.31122379
130FGR0.30670159
131DYRK1A0.30119506
132BTK0.30107234
133PTK2B0.29169940
134ILK0.27878129
135CSNK1E0.27322382

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.00509866
2DNA replication_Homo sapiens_hsa030304.22308669
3Proteasome_Homo sapiens_hsa030504.03630701
4RNA polymerase_Homo sapiens_hsa030203.80790710
5Mismatch repair_Homo sapiens_hsa034303.62320059
6* Spliceosome_Homo sapiens_hsa030402.96965854
7Homologous recombination_Homo sapiens_hsa034402.92742612
8Oxidative phosphorylation_Homo sapiens_hsa001902.85789046
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83004303
10Nucleotide excision repair_Homo sapiens_hsa034202.67538312
11Pyrimidine metabolism_Homo sapiens_hsa002402.62244463
12Parkinsons disease_Homo sapiens_hsa050122.48595496
13Protein export_Homo sapiens_hsa030602.46519182
14Base excision repair_Homo sapiens_hsa034102.45298178
15RNA transport_Homo sapiens_hsa030132.18670771
16Huntingtons disease_Homo sapiens_hsa050162.09142343
17Fanconi anemia pathway_Homo sapiens_hsa034602.01109897
18Basal transcription factors_Homo sapiens_hsa030221.94960902
19Alzheimers disease_Homo sapiens_hsa050101.88237060
20Non-homologous end-joining_Homo sapiens_hsa034501.83440715
21Cell cycle_Homo sapiens_hsa041101.83179690
22* RNA degradation_Homo sapiens_hsa030181.66962562
23Purine metabolism_Homo sapiens_hsa002301.54534460
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53601227
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50937769
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44787652
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31247069
28Selenocompound metabolism_Homo sapiens_hsa004501.26223749
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14592580
30Propanoate metabolism_Homo sapiens_hsa006401.07781577
31One carbon pool by folate_Homo sapiens_hsa006701.07667561
32Butanoate metabolism_Homo sapiens_hsa006501.04989145
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.02267198
34p53 signaling pathway_Homo sapiens_hsa041151.01066124
35Systemic lupus erythematosus_Homo sapiens_hsa053220.99977026
36Epstein-Barr virus infection_Homo sapiens_hsa051690.96566639
37mRNA surveillance pathway_Homo sapiens_hsa030150.94504667
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88710712
39Nitrogen metabolism_Homo sapiens_hsa009100.85542838
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78278293
41Caffeine metabolism_Homo sapiens_hsa002320.78195873
42Phototransduction_Homo sapiens_hsa047440.77217791
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.76455968
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76265785
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75066546
46Cardiac muscle contraction_Homo sapiens_hsa042600.72479841
47Oocyte meiosis_Homo sapiens_hsa041140.71494537
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68465673
49Nicotine addiction_Homo sapiens_hsa050330.67503144
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66463426
51Folate biosynthesis_Homo sapiens_hsa007900.61359055
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61143592
53Alcoholism_Homo sapiens_hsa050340.61065182
54Herpes simplex infection_Homo sapiens_hsa051680.59934548
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59750252
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58553655
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56996257
58Primary immunodeficiency_Homo sapiens_hsa053400.54003199
59Peroxisome_Homo sapiens_hsa041460.53659212
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52356581
61Allograft rejection_Homo sapiens_hsa053300.52133375
62Chemical carcinogenesis_Homo sapiens_hsa052040.51443996
63Graft-versus-host disease_Homo sapiens_hsa053320.49884626
64Tryptophan metabolism_Homo sapiens_hsa003800.48147802
65Glutathione metabolism_Homo sapiens_hsa004800.47654035
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47197267
67Antigen processing and presentation_Homo sapiens_hsa046120.46950746
68N-Glycan biosynthesis_Homo sapiens_hsa005100.45981716
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45953817
70Arachidonic acid metabolism_Homo sapiens_hsa005900.43001635
71Asthma_Homo sapiens_hsa053100.42135280
72Pyruvate metabolism_Homo sapiens_hsa006200.41836898
73Steroid biosynthesis_Homo sapiens_hsa001000.41759403
74Metabolic pathways_Homo sapiens_hsa011000.41123831
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39147063
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38950007
77Olfactory transduction_Homo sapiens_hsa047400.38871903
78Collecting duct acid secretion_Homo sapiens_hsa049660.38683063
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.38559811
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37518344
81Sulfur metabolism_Homo sapiens_hsa009200.37340589
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36626103
83Autoimmune thyroid disease_Homo sapiens_hsa053200.36482507
84Vibrio cholerae infection_Homo sapiens_hsa051100.36231184
85Hematopoietic cell lineage_Homo sapiens_hsa046400.35067969
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33283810
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32327500
88HTLV-I infection_Homo sapiens_hsa051660.32222120
89Retinol metabolism_Homo sapiens_hsa008300.32197093
90Viral carcinogenesis_Homo sapiens_hsa052030.32173408
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.31983123
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31529473
93Sulfur relay system_Homo sapiens_hsa041220.30906460
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29467866
95Vitamin digestion and absorption_Homo sapiens_hsa049770.28862025
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28162415
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27737834
98Serotonergic synapse_Homo sapiens_hsa047260.27368538
99Regulation of autophagy_Homo sapiens_hsa041400.25632519
100Rheumatoid arthritis_Homo sapiens_hsa053230.25505347
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24541704
102Ether lipid metabolism_Homo sapiens_hsa005650.22795141
103Shigellosis_Homo sapiens_hsa051310.21792386
104beta-Alanine metabolism_Homo sapiens_hsa004100.21280779
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20007698
106Sphingolipid metabolism_Homo sapiens_hsa006000.19741789
107Taste transduction_Homo sapiens_hsa047420.18086981
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.17763331
109Legionellosis_Homo sapiens_hsa051340.16708963
110Amphetamine addiction_Homo sapiens_hsa050310.16008241
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15659836
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15424525
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.14349633
114Hepatitis B_Homo sapiens_hsa051610.13487309
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13413408
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.13359971
117Long-term potentiation_Homo sapiens_hsa047200.13229198
118African trypanosomiasis_Homo sapiens_hsa051430.13212860
119Measles_Homo sapiens_hsa051620.12751820
120Linoleic acid metabolism_Homo sapiens_hsa005910.10539522
121Type I diabetes mellitus_Homo sapiens_hsa049400.10138085
122TGF-beta signaling pathway_Homo sapiens_hsa043500.10128161
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09008716
124Wnt signaling pathway_Homo sapiens_hsa043100.08879336
125Basal cell carcinoma_Homo sapiens_hsa052170.08864114
126Renin-angiotensin system_Homo sapiens_hsa046140.08396932
127Fatty acid elongation_Homo sapiens_hsa000620.08010329
128Thyroid cancer_Homo sapiens_hsa052160.07333845
129Pentose phosphate pathway_Homo sapiens_hsa000300.07200778
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.06093077
131Pathways in cancer_Homo sapiens_hsa052000.05797819

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