LSMEM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)7.77148741
2muscle filament sliding (GO:0030049)7.77148741
3sarcomere organization (GO:0045214)7.76799001
4cardiac myofibril assembly (GO:0055003)7.33964897
5myofibril assembly (GO:0030239)7.02458854
6actin-mediated cell contraction (GO:0070252)6.50662552
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.45958960
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.38640299
9regulation of skeletal muscle contraction (GO:0014819)6.29012844
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.26990827
11cardiac muscle contraction (GO:0060048)6.01350400
12sarcoplasmic reticulum calcium ion transport (GO:0070296)5.96678381
13regulation of relaxation of muscle (GO:1901077)5.94780768
14regulation of cell communication by electrical coupling (GO:0010649)5.68677270
15regulation of actin filament-based movement (GO:1903115)5.63176141
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.57735198
17ATP synthesis coupled proton transport (GO:0015986)5.57735198
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.56441385
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.51212842
20negative regulation of potassium ion transmembrane transport (GO:1901380)5.48459846
21striated muscle contraction (GO:0006941)5.38524814
22cardiac muscle tissue morphogenesis (GO:0055008)5.27954694
23tricarboxylic acid cycle (GO:0006099)5.27361719
24cardiac muscle cell development (GO:0055013)5.27230599
25neutrophil activation involved in immune response (GO:0002283)5.22369016
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.20465131
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.17867627
28actomyosin structure organization (GO:0031032)5.16277698
29heart process (GO:0003015)5.16059251
30heart contraction (GO:0060047)5.16059251
31plasma membrane repair (GO:0001778)5.00415226
32regulation of sarcomere organization (GO:0060297)5.00352619
33respiratory electron transport chain (GO:0022904)5.00151489
34cardiac cell development (GO:0055006)4.96769503
35regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.95778328
36actin filament-based movement (GO:0030048)4.85554454
37electron transport chain (GO:0022900)4.84001991
38muscle tissue morphogenesis (GO:0060415)4.80360609
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.79189667
40heart trabecula formation (GO:0060347)4.74247436
41response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.71411739
42regulation of striated muscle contraction (GO:0006942)4.61875445
43cardiac muscle hypertrophy (GO:0003300)4.60363267
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.57657571
45adult heart development (GO:0007512)4.55883806
46regulation of platelet aggregation (GO:0090330)4.55483670
47ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.52607570
48striated muscle hypertrophy (GO:0014897)4.42515695
49skeletal muscle contraction (GO:0003009)4.42494285
50ventricular cardiac muscle cell action potential (GO:0086005)4.42046649
51regulation of acyl-CoA biosynthetic process (GO:0050812)4.34927604
52carnitine shuttle (GO:0006853)4.31752007
53regulation of membrane repolarization (GO:0060306)4.20993035
54oxidative phosphorylation (GO:0006119)4.11206794
55regulation of the force of heart contraction (GO:0002026)4.11041795
56skeletal muscle tissue regeneration (GO:0043403)4.00990157
57skeletal muscle fiber development (GO:0048741)3.96102487
58regulation of cofactor metabolic process (GO:0051193)3.96101863
59regulation of coenzyme metabolic process (GO:0051196)3.96101863
60regulation of platelet activation (GO:0010543)3.96088451
61muscle hypertrophy (GO:0014896)3.92288800
62bundle of His cell to Purkinje myocyte communication (GO:0086069)3.91125432
63myotube cell development (GO:0014904)3.85721964
64leukocyte migration involved in inflammatory response (GO:0002523)3.83116656
65regulation of cardiac muscle cell contraction (GO:0086004)3.81836448
66negative regulation of muscle contraction (GO:0045932)3.78048008
67protein neddylation (GO:0045116)3.75608967
68response to muscle activity (GO:0014850)3.75022656
69fatty acid transmembrane transport (GO:1902001)3.73420144
70negative regulation of homotypic cell-cell adhesion (GO:0034111)3.73258488
71negative regulation of protein localization to cell surface (GO:2000009)3.71019715
72muscle contraction (GO:0006936)3.70253841
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69454392
74ATP biosynthetic process (GO:0006754)3.68290500
75thrombin receptor signaling pathway (GO:0070493)3.64349831
76regulation of cardiac muscle contraction (GO:0055117)3.63707538
77positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.63500601
78relaxation of cardiac muscle (GO:0055119)3.62790048
79neutrophil activation (GO:0042119)3.60736324
80negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.55233580
81negative regulation of striated muscle cell apoptotic process (GO:0010664)3.55122570
82skeletal muscle adaptation (GO:0043501)3.54879480
83regulation of calcium ion transmembrane transporter activity (GO:1901019)3.52679137
84regulation of calcium ion transmembrane transport (GO:1903169)3.52679137
85glucan catabolic process (GO:0009251)3.50686542
86cytidine metabolic process (GO:0046087)3.50509576
87cytidine catabolic process (GO:0006216)3.50509576
88cytidine deamination (GO:0009972)3.50509576
89striated muscle cell development (GO:0055002)3.46147748
90muscle system process (GO:0003012)3.43517854
91positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.42385094
92regulation of heart rate (GO:0002027)3.41187198
93negative regulation of calcium ion transmembrane transport (GO:1903170)3.39765339
94negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.39765339
95cellular polysaccharide catabolic process (GO:0044247)3.39664558
96cardiac muscle cell action potential involved in contraction (GO:0086002)3.39574170
97cardiac muscle cell action potential (GO:0086001)3.39358424
98creatine metabolic process (GO:0006600)3.38537210
99cell communication involved in cardiac conduction (GO:0086065)3.38061655
100G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.36054555
101regulation of cardioblast differentiation (GO:0051890)3.32396499
102germinal center formation (GO:0002467)3.32389165
103positive regulation of heart rate (GO:0010460)3.31924919
104response to inactivity (GO:0014854)3.31852608
105granulocyte activation (GO:0036230)3.31166130
106negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.25071719
107neuronal action potential propagation (GO:0019227)3.23667639
108cardiac muscle adaptation (GO:0014887)3.23490787
109cardiac muscle hypertrophy in response to stress (GO:0014898)3.23490787
110muscle hypertrophy in response to stress (GO:0003299)3.23490787
111cardiac conduction (GO:0061337)3.22660478
112negative regulation of T-helper cell differentiation (GO:0045623)3.21384811
113negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.21384811
114regulation of sulfur metabolic process (GO:0042762)3.21345822
115regulation of muscle contraction (GO:0006937)3.20121471
116striated muscle adaptation (GO:0014888)3.19550787
117cell communication by electrical coupling (GO:0010644)3.19504547
118negative regulation of platelet activation (GO:0010544)3.19015536
119positive regulation of cation channel activity (GO:2001259)3.18958353
120regulation of ATPase activity (GO:0043462)3.18472650
121regulation of ATP catabolic process (GO:1903289)3.18472650
122glycogen catabolic process (GO:0005980)3.17171255
123relaxation of muscle (GO:0090075)3.16503665
124positive regulation of myoblast differentiation (GO:0045663)3.13658428
125positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.12332635
126purinergic nucleotide receptor signaling pathway (GO:0035590)3.06612326
127polysaccharide catabolic process (GO:0000272)3.05820552
128negative regulation of thymocyte apoptotic process (GO:0070244)3.04812428
129adenosine receptor signaling pathway (GO:0001973)2.97971902
130triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.96558051
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95968387
132negative regulation of norepinephrine secretion (GO:0010700)2.91809311
133regulation of receptor recycling (GO:0001919)2.89579051
134pyrimidine nucleoside catabolic process (GO:0046135)2.89407509
135positive regulation of receptor recycling (GO:0001921)2.86648789
136negative regulation of heart rate (GO:0010459)2.81442667
137negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.80642638
138positive regulation of Rho protein signal transduction (GO:0035025)2.77809671
139blood coagulation, intrinsic pathway (GO:0007597)2.76811281
140muscle fiber development (GO:0048747)2.75205353
141lipoxygenase pathway (GO:0019372)2.74509633
142microglial cell activation (GO:0001774)2.74254363
143regulation of homotypic cell-cell adhesion (GO:0034110)2.71182998
144response to activity (GO:0014823)2.71101737
145positive regulation of mast cell activation (GO:0033005)2.68848490
146skeletal muscle tissue development (GO:0007519)2.63337460
147negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.62429921
148regulation of integrin-mediated signaling pathway (GO:2001044)2.61704437
149regulation of T-helper 2 cell differentiation (GO:0045628)2.59747118
150regulation of memory T cell differentiation (GO:0043380)2.59127971
151regulation of MHC class II biosynthetic process (GO:0045346)2.55493758
152negative regulation of heart contraction (GO:0045822)2.54284654
153positive regulation of toll-like receptor signaling pathway (GO:0034123)2.53288888
154striated muscle atrophy (GO:0014891)2.49022239
155cellular extravasation (GO:0045123)2.48383897
156negative regulation of calcium ion transport (GO:0051926)2.46767335
157purinergic receptor signaling pathway (GO:0035587)2.45276630
158negative regulation of blood circulation (GO:1903523)2.44178794
159antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42637852
160phospholipid homeostasis (GO:0055091)2.42568433
161response to epinephrine (GO:0071871)2.41824280
162glucan metabolic process (GO:0044042)2.40758821
163cellular glucan metabolic process (GO:0006073)2.40758821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse4.09156778
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.85886498
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64988665
4EZH2_22144423_ChIP-Seq_EOC_Human3.43850106
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.37425963
6CDX2_19796622_ChIP-Seq_MESCs_Mouse3.17128009
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.02364094
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.98476781
9SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.92497591
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.85272900
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.85272900
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69759607
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.68325864
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.47967793
15SCL_19346495_ChIP-Seq_HPC-7_Human2.45807258
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.44159393
17MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.28496383
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27198301
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20500048
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12290704
21LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.09284953
22GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.08404273
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05865209
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05543986
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04824126
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01402554
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96424913
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.88087427
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.87896024
30SPI1_23127762_ChIP-Seq_K562_Human1.87616802
31GATA1_19941827_ChIP-Seq_MEL_Mouse1.86308777
32GATA1_19941826_ChIP-Seq_K562_Human1.83309953
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79943763
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78037806
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77424986
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77424986
37GATA2_19941826_ChIP-Seq_K562_Human1.76908471
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76466909
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74635723
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74076970
41RUNX_20019798_ChIP-Seq_JUKART_Human1.70162828
42ZNF263_19887448_ChIP-Seq_K562_Human1.68529294
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.67747175
44GATA1_22025678_ChIP-Seq_K562_Human1.64502926
45VDR_22108803_ChIP-Seq_LS180_Human1.62744379
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60888814
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59247020
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57973268
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57061381
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.56955062
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56503479
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.51409426
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49361192
54GBX2_23144817_ChIP-Seq_PC3_Human1.49357270
55GATA4_21415370_ChIP-Seq_HL-1_Mouse1.44432303
56CJUN_26792858_Chip-Seq_BT549_Human1.41680473
57ZNF274_21170338_ChIP-Seq_K562_Hela1.40218035
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39177686
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38865099
60HTT_18923047_ChIP-ChIP_STHdh_Human1.37929402
61GATA1_19941827_ChIP-Seq_MEL86_Mouse1.36974402
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.36613622
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34889523
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34581516
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33718733
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.33415546
67AR_21572438_ChIP-Seq_LNCaP_Human1.30870213
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29571289
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28987344
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28987344
71VDR_24787735_ChIP-Seq_THP-1_Human1.28398173
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.27166230
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25041968
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24564461
75BCAT_22108803_ChIP-Seq_LS180_Human1.24310759
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23767622
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.23474621
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22889643
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.22839513
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.22460348
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22200631
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21641781
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21589055
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21439495
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20764063
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20629033
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20111548
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19585570
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19537925
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.18914222
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18901814
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.18647748
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18175107
94TAF15_26573619_Chip-Seq_HEK293_Human1.16707033
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.16236228
96SALL4_22934838_ChIP-ChIP_CD34+_Human1.16070515
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14490448
98SMAD4_21799915_ChIP-Seq_A2780_Human1.14019021
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13219533
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13213811
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11718585
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.10848421
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.07721569
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07584256
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07433559
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06880484
107TP53_18474530_ChIP-ChIP_U2OS_Human1.06834972
108SMAD4_21741376_ChIP-Seq_HESCs_Human1.06522880
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05791108
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03566344
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01320816
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.01042607
113ER_23166858_ChIP-Seq_MCF-7_Human1.00820256
114PU_27001747_Chip-Seq_BMDM_Mouse1.00696117
115STAT1_20625510_ChIP-Seq_HELA_Human1.00333105
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00222432
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00078038
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99933128
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99886736
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.99349947
121FUS_26573619_Chip-Seq_HEK293_Human0.98551815
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98445906
123P300_19829295_ChIP-Seq_ESCs_Human0.98356319
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97636224
125RNF2_27304074_Chip-Seq_ESCs_Mouse0.97147215
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.96792275
127DROSHA_22980978_ChIP-Seq_HELA_Human0.96550738
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96352106
129KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96005545
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95929478
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95871223
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95720599
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95229086
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93894482
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.93579341
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93572790
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90371631
138SPI1_20517297_ChIP-Seq_HL60_Human0.89557336
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89529568
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88936024
141HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88765780
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88453693
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.87733631
144RXR_22108803_ChIP-Seq_LS180_Human0.87416265
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86175994
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85647371
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.85621385
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85527693
149GF1_26923725_Chip-Seq_HPCs_Mouse0.84916139
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84228877
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84123878
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.84075420
153PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83630234
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82627932
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.81689276
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81553763
157CLOCK_20551151_ChIP-Seq_293T_Human0.80419120
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80287644
159STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79883347
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79509132
161KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78852698
162ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78488457
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.78388613
164NANOG_19829295_ChIP-Seq_ESCs_Human0.78107811
165SOX2_19829295_ChIP-Seq_ESCs_Human0.78107811
166OCT1_27270436_Chip-Seq_PROSTATE_Human0.77657709
167ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77309594
168JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77083814
169CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76216863
170OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76180305
171TP53_16413492_ChIP-PET_HCT116_Human0.75363634
172CTCF_27219007_Chip-Seq_Bcells_Human0.73511055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.79343047
2MP0000751_myopathy5.21766052
3MP0002837_dystrophic_cardiac_calcinosis5.19558468
4MP0004084_abnormal_cardiac_muscle5.15932336
5MP0005464_abnormal_platelet_physiology4.70128008
6MP0000749_muscle_degeneration4.67417120
7MP0004036_abnormal_muscle_relaxation4.54723556
8MP0004215_abnormal_myocardial_fiber4.32081181
9MP0004145_abnormal_muscle_electrophysio3.88313238
10MP0005330_cardiomyopathy3.58236125
11MP0003724_increased_susceptibility_to3.43891209
12MP0008004_abnormal_stomach_pH3.26633429
13MP0005620_abnormal_muscle_contractility3.12045562
14MP0002972_abnormal_cardiac_muscle3.09599436
15MP0004087_abnormal_muscle_fiber3.05896832
16MP0002106_abnormal_muscle_physiology2.95237885
17MP0004484_altered_response_of2.92472739
18MP0003303_peritoneal_inflammation2.64590328
19MP0000750_abnormal_muscle_regeneration2.53045672
20MP0003137_abnormal_impulse_conducting2.52473837
21MP0000747_muscle_weakness2.47482772
22MP0005369_muscle_phenotype2.46219960
23MP0008775_abnormal_heart_ventricle2.42042916
24MP0003828_pulmonary_edema2.32900997
25MP0001544_abnormal_cardiovascular_syste2.29728729
26MP0005385_cardiovascular_system_phenoty2.29728729
27MP0002269_muscular_atrophy2.28667205
28MP0004130_abnormal_muscle_cell2.27047449
29MP0000759_abnormal_skeletal_muscle2.26184229
30MP0010630_abnormal_cardiac_muscle2.19892305
31MP0004233_abnormal_muscle_weight2.11394726
32MP0006138_congestive_heart_failure2.07584744
33MP0004510_myositis1.99140022
34MP0004085_abnormal_heartbeat1.92390827
35MP0003950_abnormal_plasma_membrane1.88225870
36MP0003221_abnormal_cardiomyocyte_apopto1.80719733
37MP0006036_abnormal_mitochondrial_physio1.80334874
38MP0001879_abnormal_lymphatic_vessel1.79818804
39MP0002332_abnormal_exercise_endurance1.69860131
40MP0002127_abnormal_cardiovascular_syste1.59720404
41MP0010368_abnormal_lymphatic_system1.52511774
42MP0003436_decreased_susceptibility_to1.43640036
43MP0002148_abnormal_hypersensitivity_rea1.39100897
44MP0001835_abnormal_antigen_presentation1.38697518
45MP0003656_abnormal_erythrocyte_physiolo1.38545029
46MP0003879_abnormal_hair_cell1.32503246
47MP0002108_abnormal_muscle_morphology1.28286067
48MP0000343_altered_response_to1.23236896
49MP0000465_gastrointestinal_hemorrhage1.22012701
50MP0003567_abnormal_fetal_cardiomyocyte1.18650080
51MP0005000_abnormal_immune_tolerance1.18139486
52MP0006035_abnormal_mitochondrial_morpho1.12395201
53MP0002132_abnormal_respiratory_system1.08353296
54MP0009764_decreased_sensitivity_to1.08296546
55MP0002419_abnormal_innate_immunity1.07469527
56MP0001800_abnormal_humoral_immune1.06455644
57MP0005165_increased_susceptibility_to1.06159731
58MP0008260_abnormal_autophagy1.05425759
59MP0002723_abnormal_immune_serum1.04424137
60MP0001533_abnormal_skeleton_physiology1.03511795
61MP0009785_altered_susceptibility_to1.02287544
62MP0000266_abnormal_heart_morphology1.01178378
63MP0001545_abnormal_hematopoietic_system1.01104196
64MP0005397_hematopoietic_system_phenotyp1.01104196
65MP0008874_decreased_physiological_sensi0.92986422
66MP0005166_decreased_susceptibility_to0.92050949
67MP0003195_calcinosis0.91918517
68MP0003045_fibrosis0.91822883
69MP0002452_abnormal_antigen_presenting0.91101311
70MP0010155_abnormal_intestine_physiology0.90442158
71MP0000230_abnormal_systemic_arterial0.89924825
72MP0005410_abnormal_fertilization0.88524218
73MP0001790_abnormal_immune_system0.87628566
74MP0005387_immune_system_phenotype0.87628566
75MP0004147_increased_porphyrin_level0.87305761
76MP0003638_abnormal_response/metabolism_0.86958622
77MP0005671_abnormal_response_to0.86613135
78MP0003279_aneurysm0.85655082
79MP0005025_abnormal_response_to0.84399940
80MP0004043_abnormal_pH_regulation0.81162345
81MP0008872_abnormal_physiological_respon0.80807585
82MP0000013_abnormal_adipose_tissue0.80331685
83MP0000733_abnormal_muscle_development0.78857817
84MP0005666_abnormal_adipose_tissue0.78797512
85MP0009278_abnormal_bone_marrow0.78140380
86MP0001851_eye_inflammation0.77797676
87MP0005623_abnormal_meninges_morphology0.76595836
88MP0000685_abnormal_immune_system0.76562292
89MP0002234_abnormal_pharynx_morphology0.76417124
90MP0002420_abnormal_adaptive_immunity0.75119250
91MP0004947_skin_inflammation0.73978666
92MP0001819_abnormal_immune_cell0.73697525
93MP0003075_altered_response_to0.73215662
94MP0002128_abnormal_blood_circulation0.72608345
95MP0005503_abnormal_tendon_morphology0.72018233
96MP0002398_abnormal_bone_marrow0.71806615
97MP0004272_abnormal_basement_membrane0.71219666
98MP0005058_abnormal_lysosome_morphology0.71139310
99MP0001845_abnormal_inflammatory_respons0.70874941
100MP0005266_abnormal_metabolism0.70505601
101MP0005451_abnormal_body_composition0.70117959
102MP0002998_abnormal_bone_remodeling0.69072753
103MP0005171_absent_coat_pigmentation0.67372507
104MP0004883_abnormal_blood_vessel0.65413667
105MP0002909_abnormal_adrenal_gland0.65043499
106MP0005164_abnormal_response_to0.63163410
107MP0005595_abnormal_vascular_smooth0.61296562
108MP0004381_abnormal_hair_follicle0.61224684
109MP0009763_increased_sensitivity_to0.60690441
110MP0005167_abnormal_blood-brain_barrier0.58165459
111MP0000767_abnormal_smooth_muscle0.57429825
112MP0003122_maternal_imprinting0.57106361
113MP0003566_abnormal_cell_adhesion0.56989839
114MP0004185_abnormal_adipocyte_glucose0.55531445
115MP0005375_adipose_tissue_phenotype0.55006143
116MP0001727_abnormal_embryo_implantation0.54645694
117MP0009250_abnormal_appendicular_skeleto0.53630626
118MP0002295_abnormal_pulmonary_circulatio0.52965397
119MP0002971_abnormal_brown_adipose0.50307466
120MP0002925_abnormal_cardiovascular_devel0.44186969
121MP0000003_abnormal_adipose_tissue0.43534094
122MP0000762_abnormal_tongue_morphology0.43474594
123MP0008438_abnormal_cutaneous_collagen0.42339352
124MP0001440_abnormal_grooming_behavior0.40616409
125MP0002133_abnormal_respiratory_system0.39288108
126MP0005388_respiratory_system_phenotype0.39288108
127MP0005670_abnormal_white_adipose0.38648244
128MP0009384_cardiac_valve_regurgitation0.37973267
129MP0003948_abnormal_gas_homeostasis0.36488423
130MP0001614_abnormal_blood_vessel0.35128627
131MP0006054_spinal_hemorrhage0.34919393
132MP0001958_emphysema0.33980435
133MP0008569_lethality_at_weaning0.33159948
134MP0001784_abnormal_fluid_regulation0.32836230
135MP0005386_behavior/neurological_phenoty0.29822893
136MP0004924_abnormal_behavior0.29822893
137MP0009046_muscle_twitch0.28749460
138MP0005535_abnormal_body_temperature0.28492911
139MP0000249_abnormal_blood_vessel0.28376817
140MP0002933_joint_inflammation0.27924696
141MP0000372_irregular_coat_pigmentation0.27494318
142MP0002078_abnormal_glucose_homeostasis0.26764241
143MP0003806_abnormal_nucleotide_metabolis0.25978913
144MP0004270_analgesia0.25119490
145MP0005083_abnormal_biliary_tract0.24071871
146MP0005584_abnormal_enzyme/coenzyme_acti0.22193149
147MP0005275_abnormal_skin_tensile0.21590397
148MP0004142_abnormal_muscle_tone0.19070530
149MP0003385_abnormal_body_wall0.18752796

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)7.83453726
2Exercise-induced myalgia (HP:0003738)7.19213734
3Calf muscle hypertrophy (HP:0008981)6.90415214
4Muscle hypertrophy of the lower extremities (HP:0008968)6.85962242
5Sudden death (HP:0001699)6.55181190
6Prolonged bleeding time (HP:0003010)5.56353567
7Ventricular tachycardia (HP:0004756)5.36959329
8Abnormality of the calf musculature (HP:0001430)5.22616167
9Muscle fiber splitting (HP:0003555)5.16728020
10Hyporeflexia of lower limbs (HP:0002600)5.15309248
11Myoglobinuria (HP:0002913)5.11285143
12Atrial fibrillation (HP:0005110)4.93030753
13EMG: myopathic abnormalities (HP:0003458)4.71913260
14Primary atrial arrhythmia (HP:0001692)4.59323935
15Menorrhagia (HP:0000132)4.58218777
16Abnormality of the left ventricular outflow tract (HP:0011103)4.57943855
17Subaortic stenosis (HP:0001682)4.57943855
18Lipoatrophy (HP:0100578)4.57261913
19Muscle fiber inclusion bodies (HP:0100299)4.44378720
20Increased mean platelet volume (HP:0011877)4.41476775
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.40798566
22Supraventricular tachycardia (HP:0004755)4.39196037
23Supraventricular arrhythmia (HP:0005115)4.31641061
24Abnormal platelet volume (HP:0011876)4.31069787
25Petechiae (HP:0000967)4.27441121
26Rhabdomyolysis (HP:0003201)4.07936024
27Purpura (HP:0000979)3.99617836
28Nemaline bodies (HP:0003798)3.93160139
29Acute necrotizing encephalopathy (HP:0006965)3.92025776
30Syncope (HP:0001279)3.83857226
31Abnormal mitochondria in muscle tissue (HP:0008316)3.80007487
32Difficulty running (HP:0009046)3.77246608
33Muscle stiffness (HP:0003552)3.75457471
34Epistaxis (HP:0000421)3.68156049
35Dilated cardiomyopathy (HP:0001644)3.65412795
36Palpitations (HP:0001962)3.65241945
37Right ventricular cardiomyopathy (HP:0011663)3.59697732
38Prolonged QT interval (HP:0001657)3.58586775
39Asymmetric septal hypertrophy (HP:0001670)3.55663553
40Myotonia (HP:0002486)3.52109577
41Type 1 muscle fiber predominance (HP:0003803)3.50837096
42Bundle branch block (HP:0011710)3.49526289
43Increased connective tissue (HP:0009025)3.48537095
44Ventricular arrhythmia (HP:0004308)3.40739668
45Progressive macrocephaly (HP:0004481)3.32214731
46Distal lower limb muscle weakness (HP:0009053)3.25372378
47Acute encephalopathy (HP:0006846)3.23189031
48Gingival bleeding (HP:0000225)3.19623638
49Centrally nucleated skeletal muscle fibers (HP:0003687)3.14575844
50Hyperlipoproteinemia (HP:0010980)3.05466595
51Frequent falls (HP:0002359)3.02601280
52Paralysis (HP:0003470)3.02352320
53Calcaneovalgus deformity (HP:0001848)2.97521866
54Areflexia of lower limbs (HP:0002522)2.96759926
55Heart block (HP:0012722)2.94492569
56Mitochondrial inheritance (HP:0001427)2.93382415
57Spontaneous hematomas (HP:0007420)2.92420497
58Ventricular fibrillation (HP:0001663)2.88560132
59Exercise intolerance (HP:0003546)2.86281208
60Neck muscle weakness (HP:0000467)2.82295304
61Abnormal atrioventricular conduction (HP:0005150)2.80569758
62Hepatic necrosis (HP:0002605)2.75232527
63Distal arthrogryposis (HP:0005684)2.68994329
64Increased CSF lactate (HP:0002490)2.68007627
65Cerebral edema (HP:0002181)2.65590906
66Left ventricular hypertrophy (HP:0001712)2.65149154
67Abnormal EKG (HP:0003115)2.56499089
68Deformed tarsal bones (HP:0008119)2.56406327
69Increased variability in muscle fiber diameter (HP:0003557)2.56003757
70Abnormality of skeletal muscle fiber size (HP:0012084)2.53856336
71Atrioventricular block (HP:0001678)2.52712550
72Difficulty climbing stairs (HP:0003551)2.52343166
73Malignant hyperthermia (HP:0002047)2.51680046
74Hepatocellular necrosis (HP:0001404)2.51154887
75Round ear (HP:0100830)2.49066849
76Weak cry (HP:0001612)2.47318079
77Abnormal finger flexion creases (HP:0006143)2.46219196
78Congenital malformation of the right heart (HP:0011723)2.46160702
79Double outlet right ventricle (HP:0001719)2.46160702
80Bulbar palsy (HP:0001283)2.41303026
81Abnormality of alanine metabolism (HP:0010916)2.39543933
82Hyperalaninemia (HP:0003348)2.39543933
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39543933
84Pheochromocytoma (HP:0002666)2.33022112
85Conjunctival hamartoma (HP:0100780)2.32169135
86Rimmed vacuoles (HP:0003805)2.31233727
87Abnormal platelet function (HP:0011869)2.30615158
88Impaired platelet aggregation (HP:0003540)2.30615158
89Stomatitis (HP:0010280)2.28267471
90Neoplasm of head and neck (HP:0012288)2.23884968
91Esophageal neoplasm (HP:0100751)2.23884968
92Hypoplastic ischia (HP:0003175)2.23607561
93Increased muscle lipid content (HP:0009058)2.22624370
94Ragged-red muscle fibers (HP:0003200)2.20760106
95Palmoplantar keratoderma (HP:0000982)2.18293888
96Hypoglycemic coma (HP:0001325)2.18144614
97Respiratory failure (HP:0002878)2.17777446
98Neuroendocrine neoplasm (HP:0100634)2.16067662
99Lactic acidosis (HP:0003128)2.15909530
100Increased intramyocellular lipid droplets (HP:0012240)2.11796035
101Muscular dystrophy (HP:0003560)2.11441581
102Poikilocytosis (HP:0004447)2.10719898
103Distal lower limb amyotrophy (HP:0008944)2.10043121
104Generalized muscle weakness (HP:0003324)2.09681288
105Abnormal pupillary function (HP:0007686)2.09502404
106Increased serum pyruvate (HP:0003542)2.08758217
107Abnormality of glycolysis (HP:0004366)2.08758217
108Myopathic facies (HP:0002058)2.07598490
109Ketoacidosis (HP:0001993)2.07498931
110Hyperkalemia (HP:0002153)2.01117507
111Fatigable weakness (HP:0003473)1.98125710
112Abnormality of the neuromuscular junction (HP:0003398)1.98125710
113Dyschromatopsia (HP:0007641)1.98004765
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97372355
115Limb-girdle muscle atrophy (HP:0003797)1.96981040
116Abnormality of lateral ventricle (HP:0030047)1.95568119
117Hypoplastic left heart (HP:0004383)1.94194047
118Abnormality of macrophages (HP:0004311)1.94183490
119Optic disc pallor (HP:0000543)1.92637856
120Abnormality of the ischium (HP:0003174)1.92186757
121Ulnar deviation of the wrist (HP:0003049)1.91285411
122EMG: neuropathic changes (HP:0003445)1.89678299
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87102320
124Dicarboxylic aciduria (HP:0003215)1.87102320
125Lipid accumulation in hepatocytes (HP:0006561)1.86040600
126Chest pain (HP:0100749)1.85806665
127Slender build (HP:0001533)1.85386288
128Facial diplegia (HP:0001349)1.79187438
129Lower limb amyotrophy (HP:0007210)1.78070175
130Gowers sign (HP:0003391)1.75668006
131Abnormality of the foot musculature (HP:0001436)1.74461677
132Waddling gait (HP:0002515)1.74075694
133Progressive muscle weakness (HP:0003323)1.73300729
134Absent phalangeal crease (HP:0006109)1.72344513
135Abnormality of iron homeostasis (HP:0011031)1.71428143
136Fetal akinesia sequence (HP:0001989)1.70363056
137Bruising susceptibility (HP:0000978)1.69841066
138Conjunctival telangiectasia (HP:0000524)1.69144054
139Acanthocytosis (HP:0001927)1.67899043
140Arterial thrombosis (HP:0004420)1.63862766
141Retrobulbar optic neuritis (HP:0100654)1.63697265
142Optic neuritis (HP:0100653)1.63697265
143Nonprogressive disorder (HP:0003680)1.60745064
144Eczematoid dermatitis (HP:0000976)1.58928595
145Episodic fever (HP:0001954)1.58376503
146Abnormality of the vasculature of the conjunctiva (HP:0008054)1.57965604
147Vertigo (HP:0002321)1.57786802
148Increased serum ferritin (HP:0003281)1.54298344
149Mildly elevated creatine phosphokinase (HP:0008180)1.53594982
150Scapular winging (HP:0003691)1.53430556
151Orchitis (HP:0100796)1.52905090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.06129747
2TTN5.29053807
3PHKG13.98729524
4PHKG23.98729524
5MYLK3.48703020
6PDK32.85690303
7PDK42.85690303
8STK242.79661884
9MST42.64385468
10LMTK22.64143298
11DMPK2.53269509
12PIK3CA2.14183041
13MUSK2.12635810
14PDK22.09671466
15PINK11.97797013
16BMX1.93201512
17NME11.86937843
18CAMK1G1.68860348
19KDR1.66296456
20TIE11.64555581
21TAOK31.64541059
22CAMK1D1.61494143
23GRK71.59385686
24BTK1.48613807
25CAMKK21.47553175
26WNK41.44714538
27ZAP701.42748100
28TEC1.42476683
29MAPK121.42257924
30BCKDK1.39865151
31TNK21.39381642
32ZAK1.39286716
33STK38L1.32675602
34BLK1.31146768
35PKN21.28296221
36RIPK11.26560119
37SYK1.23105720
38PIK3CG1.23049337
39DYRK1B1.22687140
40IRAK41.21932118
41TAOK11.21891626
42ACVR1B1.20613124
43MAP3K71.18760624
44NEK11.18329709
45IRAK11.16954233
46PTK2B1.16808465
47CAMK2D1.16639430
48MAP2K31.15282587
49TRPM71.11404141
50PRPF4B1.10111066
51PRKAA21.08345485
52PAK31.06978171
53INSRR1.04991008
54LIMK11.04881190
55CDC42BPA1.02806565
56IKBKB1.01640957
57IRAK21.00028117
58HCK0.99397075
59FGR0.98236823
60EIF2AK10.93055087
61DAPK20.91669948
62PRKD10.90631635
63ILK0.90377876
64CAMK10.89016890
65PRKAA10.88518328
66MAP3K30.88271309
67STK390.87522141
68EPHA30.85747767
69CSF1R0.83822303
70ROCK10.83117560
71MAP3K110.81417926
72TAOK20.79858391
73PKN10.79477642
74WNK10.79021701
75CAMK40.78545284
76EPHB10.76264299
77CSK0.76074741
78MAP2K40.75567125
79MAP3K120.74558275
80MAP3K10.74009304
81MAP3K140.71655459
82TRIB30.71129049
83GRK60.70999035
84TXK0.70687925
85CAMK2A0.69919615
86GRK50.68015128
87TBK10.67070705
88MAPKAPK30.66955776
89SGK30.65714892
90ROCK20.63698160
91SIK30.63571022
92DAPK30.62282093
93JAK20.60852636
94MAP2K10.60118717
95LYN0.58759781
96ADRBK20.58237683
97CAMK2G0.57024072
98FRK0.56104658
99TYK20.53851970
100MAP3K50.52738009
101MAPK70.52374140
102RIPK40.50038638
103IKBKE0.48953135
104SGK20.48939079
105TGFBR20.47993441
106PRKACA0.46999892
107PAK60.45493379
108STK30.45372347
109NME20.44315089
110EPHB20.44285978
111MATK0.43798397
112IRAK30.43171629
113EPHA40.41859206
114KSR20.41650851
115PRKG20.41593354
116MAPK130.40608538
117PRKG10.39865600
118MAP3K130.39500395
119PRKCE0.39292801
120PLK20.38336451
121STK40.37420365
122AKT20.37250277
123DYRK1A0.37163301
124PRKCQ0.35823718
125PAK10.35356425
126PRKACB0.32112981
127JAK30.31282775
128DYRK30.31082599
129CAMKK10.30548194
130JAK10.29937706
131SGK10.29050874
132PRKACG0.28954032
133MAPK40.28268089
134PDK10.27761898
135CCNB10.26981920
136TNIK0.26233887
137MAPK110.26069176
138ADRBK10.24975331
139PNCK0.24374955
140BMPR20.24357514
141PDPK10.22760690
142MAP3K40.22515587
143MAP2K60.21313260
144CAMK2B0.20159823
145KSR10.19298318
146MAP3K60.19166300
147MARK30.19127281
148LATS20.16624564
149RAF10.11599869
150MOS0.11441300
151FER0.11439984
152RPS6KC10.11431826
153RPS6KL10.11431826
154PRKCH0.11370835
155RPS6KA30.11146541
156ERBB30.11134988

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.85296657
2Cardiac muscle contraction_Homo sapiens_hsa042604.80160003
3Oxidative phosphorylation_Homo sapiens_hsa001904.41432445
4Parkinsons disease_Homo sapiens_hsa050124.23542772
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.59071319
6Dilated cardiomyopathy_Homo sapiens_hsa054143.48848003
7Alzheimers disease_Homo sapiens_hsa050103.34496161
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84401725
9Huntingtons disease_Homo sapiens_hsa050162.83889331
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.83074984
11Propanoate metabolism_Homo sapiens_hsa006402.76335533
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54714923
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17701396
14Carbon metabolism_Homo sapiens_hsa012001.91260652
15Nitrogen metabolism_Homo sapiens_hsa009101.88976446
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80244729
17Fatty acid degradation_Homo sapiens_hsa000711.72661255
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62576716
19Osteoclast differentiation_Homo sapiens_hsa043801.62115182
20Pyruvate metabolism_Homo sapiens_hsa006201.61555618
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56933290
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52667451
23Viral myocarditis_Homo sapiens_hsa054161.46137076
24Fatty acid metabolism_Homo sapiens_hsa012121.44844153
25Chemokine signaling pathway_Homo sapiens_hsa040621.44368547
26Hematopoietic cell lineage_Homo sapiens_hsa046401.39155248
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39140962
28Legionellosis_Homo sapiens_hsa051341.34116564
29B cell receptor signaling pathway_Homo sapiens_hsa046621.31142094
30Starch and sucrose metabolism_Homo sapiens_hsa005001.27803140
31Calcium signaling pathway_Homo sapiens_hsa040201.21757495
32Malaria_Homo sapiens_hsa051441.19696919
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19527009
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18033424
35Oxytocin signaling pathway_Homo sapiens_hsa049211.15173081
36Glucagon signaling pathway_Homo sapiens_hsa049221.13881808
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10358867
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05748939
39T cell receptor signaling pathway_Homo sapiens_hsa046601.03371080
40Fatty acid elongation_Homo sapiens_hsa000621.02014910
41Staphylococcus aureus infection_Homo sapiens_hsa051501.01930885
42Leishmaniasis_Homo sapiens_hsa051401.01812394
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00812029
44Tuberculosis_Homo sapiens_hsa051520.98446227
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98160381
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96276049
47Insulin resistance_Homo sapiens_hsa049310.95173312
48Arachidonic acid metabolism_Homo sapiens_hsa005900.91340451
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89780767
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.89047793
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.88167826
52Butanoate metabolism_Homo sapiens_hsa006500.84676746
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84245394
54Pentose phosphate pathway_Homo sapiens_hsa000300.83563799
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83339307
56HIF-1 signaling pathway_Homo sapiens_hsa040660.83106682
57TNF signaling pathway_Homo sapiens_hsa046680.82438017
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82389058
59Focal adhesion_Homo sapiens_hsa045100.81768203
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.77232253
61Renin secretion_Homo sapiens_hsa049240.76253780
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75880533
63Circadian entrainment_Homo sapiens_hsa047130.75634513
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75474503
65Circadian rhythm_Homo sapiens_hsa047100.74533388
66Insulin signaling pathway_Homo sapiens_hsa049100.73864728
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.73716830
68Linoleic acid metabolism_Homo sapiens_hsa005910.71362609
69Gastric acid secretion_Homo sapiens_hsa049710.70189348
70Arginine and proline metabolism_Homo sapiens_hsa003300.69410334
71Biosynthesis of amino acids_Homo sapiens_hsa012300.67508647
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67424401
73Endocytosis_Homo sapiens_hsa041440.67044809
74Collecting duct acid secretion_Homo sapiens_hsa049660.66965500
75Tight junction_Homo sapiens_hsa045300.66423314
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66028302
77Galactose metabolism_Homo sapiens_hsa000520.63323518
78VEGF signaling pathway_Homo sapiens_hsa043700.63200361
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.62864564
80Non-small cell lung cancer_Homo sapiens_hsa052230.62110841
81Measles_Homo sapiens_hsa051620.61527840
82Influenza A_Homo sapiens_hsa051640.59119032
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58586337
84cAMP signaling pathway_Homo sapiens_hsa040240.58415895
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57569974
86Olfactory transduction_Homo sapiens_hsa047400.53808554
87Taste transduction_Homo sapiens_hsa047420.53498136
88Glycerolipid metabolism_Homo sapiens_hsa005610.53201400
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52515217
90beta-Alanine metabolism_Homo sapiens_hsa004100.51641324
91AMPK signaling pathway_Homo sapiens_hsa041520.51537383
92Toxoplasmosis_Homo sapiens_hsa051450.51363145
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50771852
94ECM-receptor interaction_Homo sapiens_hsa045120.50724304
95Insulin secretion_Homo sapiens_hsa049110.50314077
96Choline metabolism in cancer_Homo sapiens_hsa052310.49638641
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49424414
98PPAR signaling pathway_Homo sapiens_hsa033200.48636986
99Shigellosis_Homo sapiens_hsa051310.48079013
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47286811
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.47120004
102Long-term depression_Homo sapiens_hsa047300.46849272
103Pertussis_Homo sapiens_hsa051330.46581628
104Phagosome_Homo sapiens_hsa041450.46237513
105Fatty acid biosynthesis_Homo sapiens_hsa000610.45427177
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45367553
107Glioma_Homo sapiens_hsa052140.44887041
108Morphine addiction_Homo sapiens_hsa050320.44179198
109Regulation of autophagy_Homo sapiens_hsa041400.44146223
110Salmonella infection_Homo sapiens_hsa051320.43244866
111Sulfur metabolism_Homo sapiens_hsa009200.42050564
112GABAergic synapse_Homo sapiens_hsa047270.41357479
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41052828
114Serotonergic synapse_Homo sapiens_hsa047260.40815787
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40765911
116African trypanosomiasis_Homo sapiens_hsa051430.40090823
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.39687538
118Cholinergic synapse_Homo sapiens_hsa047250.38846004
119Type II diabetes mellitus_Homo sapiens_hsa049300.38714431
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38031316
121Salivary secretion_Homo sapiens_hsa049700.37569631
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37400123
123Phenylalanine metabolism_Homo sapiens_hsa003600.36755700
124Adherens junction_Homo sapiens_hsa045200.36501776
125GnRH signaling pathway_Homo sapiens_hsa049120.36476679
126Long-term potentiation_Homo sapiens_hsa047200.35767759
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34825298
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.33221216
129Amoebiasis_Homo sapiens_hsa051460.31734875
130Fructose and mannose metabolism_Homo sapiens_hsa000510.31323973
131Dopaminergic synapse_Homo sapiens_hsa047280.30715709
132Pancreatic secretion_Homo sapiens_hsa049720.29032340
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28964337
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28950823
135Amphetamine addiction_Homo sapiens_hsa050310.28660165
136Metabolic pathways_Homo sapiens_hsa011000.28330303
137Melanogenesis_Homo sapiens_hsa049160.27971528
138Proteoglycans in cancer_Homo sapiens_hsa052050.27623625
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27286622
140Peroxisome_Homo sapiens_hsa041460.26536298
141MAPK signaling pathway_Homo sapiens_hsa040100.26423096
142Gap junction_Homo sapiens_hsa045400.26388107
143FoxO signaling pathway_Homo sapiens_hsa040680.26075976
144Arginine biosynthesis_Homo sapiens_hsa002200.24710996
145Glutamatergic synapse_Homo sapiens_hsa047240.24105146
146Platelet activation_Homo sapiens_hsa046110.23301363
147Rap1 signaling pathway_Homo sapiens_hsa040150.20503442
148Renal cell carcinoma_Homo sapiens_hsa052110.19594222
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19094296
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18931525
151Dorso-ventral axis formation_Homo sapiens_hsa043200.18610613
152Tryptophan metabolism_Homo sapiens_hsa003800.16507091
153Ras signaling pathway_Homo sapiens_hsa040140.14700083
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12922251

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