

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | actin-myosin filament sliding (GO:0033275) | 7.77148741 |
| 2 | muscle filament sliding (GO:0030049) | 7.77148741 |
| 3 | sarcomere organization (GO:0045214) | 7.76799001 |
| 4 | cardiac myofibril assembly (GO:0055003) | 7.33964897 |
| 5 | myofibril assembly (GO:0030239) | 7.02458854 |
| 6 | actin-mediated cell contraction (GO:0070252) | 6.50662552 |
| 7 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 6.45958960 |
| 8 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 6.38640299 |
| 9 | regulation of skeletal muscle contraction (GO:0014819) | 6.29012844 |
| 10 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.26990827 |
| 11 | cardiac muscle contraction (GO:0060048) | 6.01350400 |
| 12 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 5.96678381 |
| 13 | regulation of relaxation of muscle (GO:1901077) | 5.94780768 |
| 14 | regulation of cell communication by electrical coupling (GO:0010649) | 5.68677270 |
| 15 | regulation of actin filament-based movement (GO:1903115) | 5.63176141 |
| 16 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.57735198 |
| 17 | ATP synthesis coupled proton transport (GO:0015986) | 5.57735198 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.56441385 |
| 19 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.51212842 |
| 20 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 5.48459846 |
| 21 | striated muscle contraction (GO:0006941) | 5.38524814 |
| 22 | cardiac muscle tissue morphogenesis (GO:0055008) | 5.27954694 |
| 23 | tricarboxylic acid cycle (GO:0006099) | 5.27361719 |
| 24 | cardiac muscle cell development (GO:0055013) | 5.27230599 |
| 25 | neutrophil activation involved in immune response (GO:0002283) | 5.22369016 |
| 26 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.20465131 |
| 27 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.17867627 |
| 28 | actomyosin structure organization (GO:0031032) | 5.16277698 |
| 29 | heart process (GO:0003015) | 5.16059251 |
| 30 | heart contraction (GO:0060047) | 5.16059251 |
| 31 | plasma membrane repair (GO:0001778) | 5.00415226 |
| 32 | regulation of sarcomere organization (GO:0060297) | 5.00352619 |
| 33 | respiratory electron transport chain (GO:0022904) | 5.00151489 |
| 34 | cardiac cell development (GO:0055006) | 4.96769503 |
| 35 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.95778328 |
| 36 | actin filament-based movement (GO:0030048) | 4.85554454 |
| 37 | electron transport chain (GO:0022900) | 4.84001991 |
| 38 | muscle tissue morphogenesis (GO:0060415) | 4.80360609 |
| 39 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.79189667 |
| 40 | heart trabecula formation (GO:0060347) | 4.74247436 |
| 41 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.71411739 |
| 42 | regulation of striated muscle contraction (GO:0006942) | 4.61875445 |
| 43 | cardiac muscle hypertrophy (GO:0003300) | 4.60363267 |
| 44 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 4.57657571 |
| 45 | adult heart development (GO:0007512) | 4.55883806 |
| 46 | regulation of platelet aggregation (GO:0090330) | 4.55483670 |
| 47 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.52607570 |
| 48 | striated muscle hypertrophy (GO:0014897) | 4.42515695 |
| 49 | skeletal muscle contraction (GO:0003009) | 4.42494285 |
| 50 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.42046649 |
| 51 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.34927604 |
| 52 | carnitine shuttle (GO:0006853) | 4.31752007 |
| 53 | regulation of membrane repolarization (GO:0060306) | 4.20993035 |
| 54 | oxidative phosphorylation (GO:0006119) | 4.11206794 |
| 55 | regulation of the force of heart contraction (GO:0002026) | 4.11041795 |
| 56 | skeletal muscle tissue regeneration (GO:0043403) | 4.00990157 |
| 57 | skeletal muscle fiber development (GO:0048741) | 3.96102487 |
| 58 | regulation of cofactor metabolic process (GO:0051193) | 3.96101863 |
| 59 | regulation of coenzyme metabolic process (GO:0051196) | 3.96101863 |
| 60 | regulation of platelet activation (GO:0010543) | 3.96088451 |
| 61 | muscle hypertrophy (GO:0014896) | 3.92288800 |
| 62 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.91125432 |
| 63 | myotube cell development (GO:0014904) | 3.85721964 |
| 64 | leukocyte migration involved in inflammatory response (GO:0002523) | 3.83116656 |
| 65 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.81836448 |
| 66 | negative regulation of muscle contraction (GO:0045932) | 3.78048008 |
| 67 | protein neddylation (GO:0045116) | 3.75608967 |
| 68 | response to muscle activity (GO:0014850) | 3.75022656 |
| 69 | fatty acid transmembrane transport (GO:1902001) | 3.73420144 |
| 70 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 3.73258488 |
| 71 | negative regulation of protein localization to cell surface (GO:2000009) | 3.71019715 |
| 72 | muscle contraction (GO:0006936) | 3.70253841 |
| 73 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.69454392 |
| 74 | ATP biosynthetic process (GO:0006754) | 3.68290500 |
| 75 | thrombin receptor signaling pathway (GO:0070493) | 3.64349831 |
| 76 | regulation of cardiac muscle contraction (GO:0055117) | 3.63707538 |
| 77 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.63500601 |
| 78 | relaxation of cardiac muscle (GO:0055119) | 3.62790048 |
| 79 | neutrophil activation (GO:0042119) | 3.60736324 |
| 80 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.55233580 |
| 81 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 3.55122570 |
| 82 | skeletal muscle adaptation (GO:0043501) | 3.54879480 |
| 83 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.52679137 |
| 84 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.52679137 |
| 85 | glucan catabolic process (GO:0009251) | 3.50686542 |
| 86 | cytidine metabolic process (GO:0046087) | 3.50509576 |
| 87 | cytidine catabolic process (GO:0006216) | 3.50509576 |
| 88 | cytidine deamination (GO:0009972) | 3.50509576 |
| 89 | striated muscle cell development (GO:0055002) | 3.46147748 |
| 90 | muscle system process (GO:0003012) | 3.43517854 |
| 91 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.42385094 |
| 92 | regulation of heart rate (GO:0002027) | 3.41187198 |
| 93 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.39765339 |
| 94 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.39765339 |
| 95 | cellular polysaccharide catabolic process (GO:0044247) | 3.39664558 |
| 96 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.39574170 |
| 97 | cardiac muscle cell action potential (GO:0086001) | 3.39358424 |
| 98 | creatine metabolic process (GO:0006600) | 3.38537210 |
| 99 | cell communication involved in cardiac conduction (GO:0086065) | 3.38061655 |
| 100 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 3.36054555 |
| 101 | regulation of cardioblast differentiation (GO:0051890) | 3.32396499 |
| 102 | germinal center formation (GO:0002467) | 3.32389165 |
| 103 | positive regulation of heart rate (GO:0010460) | 3.31924919 |
| 104 | response to inactivity (GO:0014854) | 3.31852608 |
| 105 | granulocyte activation (GO:0036230) | 3.31166130 |
| 106 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 3.25071719 |
| 107 | neuronal action potential propagation (GO:0019227) | 3.23667639 |
| 108 | cardiac muscle adaptation (GO:0014887) | 3.23490787 |
| 109 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.23490787 |
| 110 | muscle hypertrophy in response to stress (GO:0003299) | 3.23490787 |
| 111 | cardiac conduction (GO:0061337) | 3.22660478 |
| 112 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.21384811 |
| 113 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.21384811 |
| 114 | regulation of sulfur metabolic process (GO:0042762) | 3.21345822 |
| 115 | regulation of muscle contraction (GO:0006937) | 3.20121471 |
| 116 | striated muscle adaptation (GO:0014888) | 3.19550787 |
| 117 | cell communication by electrical coupling (GO:0010644) | 3.19504547 |
| 118 | negative regulation of platelet activation (GO:0010544) | 3.19015536 |
| 119 | positive regulation of cation channel activity (GO:2001259) | 3.18958353 |
| 120 | regulation of ATPase activity (GO:0043462) | 3.18472650 |
| 121 | regulation of ATP catabolic process (GO:1903289) | 3.18472650 |
| 122 | glycogen catabolic process (GO:0005980) | 3.17171255 |
| 123 | relaxation of muscle (GO:0090075) | 3.16503665 |
| 124 | positive regulation of myoblast differentiation (GO:0045663) | 3.13658428 |
| 125 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.12332635 |
| 126 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 3.06612326 |
| 127 | polysaccharide catabolic process (GO:0000272) | 3.05820552 |
| 128 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.04812428 |
| 129 | adenosine receptor signaling pathway (GO:0001973) | 2.97971902 |
| 130 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.96558051 |
| 131 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.95968387 |
| 132 | negative regulation of norepinephrine secretion (GO:0010700) | 2.91809311 |
| 133 | regulation of receptor recycling (GO:0001919) | 2.89579051 |
| 134 | pyrimidine nucleoside catabolic process (GO:0046135) | 2.89407509 |
| 135 | positive regulation of receptor recycling (GO:0001921) | 2.86648789 |
| 136 | negative regulation of heart rate (GO:0010459) | 2.81442667 |
| 137 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 2.80642638 |
| 138 | positive regulation of Rho protein signal transduction (GO:0035025) | 2.77809671 |
| 139 | blood coagulation, intrinsic pathway (GO:0007597) | 2.76811281 |
| 140 | muscle fiber development (GO:0048747) | 2.75205353 |
| 141 | lipoxygenase pathway (GO:0019372) | 2.74509633 |
| 142 | microglial cell activation (GO:0001774) | 2.74254363 |
| 143 | regulation of homotypic cell-cell adhesion (GO:0034110) | 2.71182998 |
| 144 | response to activity (GO:0014823) | 2.71101737 |
| 145 | positive regulation of mast cell activation (GO:0033005) | 2.68848490 |
| 146 | skeletal muscle tissue development (GO:0007519) | 2.63337460 |
| 147 | negative regulation of phosphoprotein phosphatase activity (GO:0032515) | 2.62429921 |
| 148 | regulation of integrin-mediated signaling pathway (GO:2001044) | 2.61704437 |
| 149 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.59747118 |
| 150 | regulation of memory T cell differentiation (GO:0043380) | 2.59127971 |
| 151 | regulation of MHC class II biosynthetic process (GO:0045346) | 2.55493758 |
| 152 | negative regulation of heart contraction (GO:0045822) | 2.54284654 |
| 153 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.53288888 |
| 154 | striated muscle atrophy (GO:0014891) | 2.49022239 |
| 155 | cellular extravasation (GO:0045123) | 2.48383897 |
| 156 | negative regulation of calcium ion transport (GO:0051926) | 2.46767335 |
| 157 | purinergic receptor signaling pathway (GO:0035587) | 2.45276630 |
| 158 | negative regulation of blood circulation (GO:1903523) | 2.44178794 |
| 159 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.42637852 |
| 160 | phospholipid homeostasis (GO:0055091) | 2.42568433 |
| 161 | response to epinephrine (GO:0071871) | 2.41824280 |
| 162 | glucan metabolic process (GO:0044042) | 2.40758821 |
| 163 | cellular glucan metabolic process (GO:0006073) | 2.40758821 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 4.09156778 |
| 2 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 3.85886498 |
| 3 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.64988665 |
| 4 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.43850106 |
| 5 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 3.37425963 |
| 6 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 3.17128009 |
| 7 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 3.02364094 |
| 8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.98476781 |
| 9 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 2.92497591 |
| 10 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 2.85272900 |
| 11 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 2.85272900 |
| 12 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.69759607 |
| 13 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.68325864 |
| 14 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.47967793 |
| 15 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.45807258 |
| 16 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.44159393 |
| 17 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.28496383 |
| 18 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.27198301 |
| 19 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.20500048 |
| 20 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.12290704 |
| 21 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 2.09284953 |
| 22 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 2.08404273 |
| 23 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.05865209 |
| 24 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.05543986 |
| 25 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.04824126 |
| 26 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.01402554 |
| 27 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.96424913 |
| 28 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.88087427 |
| 29 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.87896024 |
| 30 | SPI1_23127762_ChIP-Seq_K562_Human | 1.87616802 |
| 31 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.86308777 |
| 32 | GATA1_19941826_ChIP-Seq_K562_Human | 1.83309953 |
| 33 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.79943763 |
| 34 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.78037806 |
| 35 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.77424986 |
| 36 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.77424986 |
| 37 | GATA2_19941826_ChIP-Seq_K562_Human | 1.76908471 |
| 38 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.76466909 |
| 39 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.74635723 |
| 40 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.74076970 |
| 41 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.70162828 |
| 42 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.68529294 |
| 43 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.67747175 |
| 44 | GATA1_22025678_ChIP-Seq_K562_Human | 1.64502926 |
| 45 | VDR_22108803_ChIP-Seq_LS180_Human | 1.62744379 |
| 46 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.60888814 |
| 47 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.59247020 |
| 48 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.57973268 |
| 49 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.57061381 |
| 50 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.56955062 |
| 51 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.56503479 |
| 52 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.51409426 |
| 53 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.49361192 |
| 54 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.49357270 |
| 55 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.44432303 |
| 56 | CJUN_26792858_Chip-Seq_BT549_Human | 1.41680473 |
| 57 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.40218035 |
| 58 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.39177686 |
| 59 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.38865099 |
| 60 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.37929402 |
| 61 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.36974402 |
| 62 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.36613622 |
| 63 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.34889523 |
| 64 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.34581516 |
| 65 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.33718733 |
| 66 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.33415546 |
| 67 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.30870213 |
| 68 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.29571289 |
| 69 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.28987344 |
| 70 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.28987344 |
| 71 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.28398173 |
| 72 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.27166230 |
| 73 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.25041968 |
| 74 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.24564461 |
| 75 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.24310759 |
| 76 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.23767622 |
| 77 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.23474621 |
| 78 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.22889643 |
| 79 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.22839513 |
| 80 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.22460348 |
| 81 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.22200631 |
| 82 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21641781 |
| 83 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.21589055 |
| 84 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.21439495 |
| 85 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.20764063 |
| 86 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.20629033 |
| 87 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.20111548 |
| 88 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.19585570 |
| 89 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.19537925 |
| 90 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.18914222 |
| 91 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.18901814 |
| 92 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.18647748 |
| 93 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.18175107 |
| 94 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.16707033 |
| 95 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.16236228 |
| 96 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.16070515 |
| 97 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.14490448 |
| 98 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.14019021 |
| 99 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.13219533 |
| 100 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.13213811 |
| 101 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.11718585 |
| 102 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.10848421 |
| 103 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.07721569 |
| 104 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.07584256 |
| 105 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.07433559 |
| 106 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.06880484 |
| 107 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.06834972 |
| 108 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.06522880 |
| 109 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.05791108 |
| 110 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.03566344 |
| 111 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.01320816 |
| 112 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.01042607 |
| 113 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.00820256 |
| 114 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.00696117 |
| 115 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.00333105 |
| 116 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.00222432 |
| 117 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.00078038 |
| 118 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.99933128 |
| 119 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.99886736 |
| 120 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.99349947 |
| 121 | FUS_26573619_Chip-Seq_HEK293_Human | 0.98551815 |
| 122 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.98445906 |
| 123 | P300_19829295_ChIP-Seq_ESCs_Human | 0.98356319 |
| 124 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.97636224 |
| 125 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.97147215 |
| 126 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.96792275 |
| 127 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.96550738 |
| 128 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.96352106 |
| 129 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.96005545 |
| 130 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.95929478 |
| 131 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.95871223 |
| 132 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.95720599 |
| 133 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.95229086 |
| 134 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.93894482 |
| 135 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.93579341 |
| 136 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.93572790 |
| 137 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.90371631 |
| 138 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.89557336 |
| 139 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.89529568 |
| 140 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.88936024 |
| 141 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.88765780 |
| 142 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.88453693 |
| 143 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.87733631 |
| 144 | RXR_22108803_ChIP-Seq_LS180_Human | 0.87416265 |
| 145 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.86175994 |
| 146 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.85647371 |
| 147 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.85621385 |
| 148 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.85527693 |
| 149 | GF1_26923725_Chip-Seq_HPCs_Mouse | 0.84916139 |
| 150 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.84228877 |
| 151 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.84123878 |
| 152 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.84075420 |
| 153 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.83630234 |
| 154 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.82627932 |
| 155 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.81689276 |
| 156 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81553763 |
| 157 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.80419120 |
| 158 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.80287644 |
| 159 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.79883347 |
| 160 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.79509132 |
| 161 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.78852698 |
| 162 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.78488457 |
| 163 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.78388613 |
| 164 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.78107811 |
| 165 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.78107811 |
| 166 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.77657709 |
| 167 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.77309594 |
| 168 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.77083814 |
| 169 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.76216863 |
| 170 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.76180305 |
| 171 | TP53_16413492_ChIP-PET_HCT116_Human | 0.75363634 |
| 172 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.73511055 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 5.79343047 |
| 2 | MP0000751_myopathy | 5.21766052 |
| 3 | MP0002837_dystrophic_cardiac_calcinosis | 5.19558468 |
| 4 | MP0004084_abnormal_cardiac_muscle | 5.15932336 |
| 5 | MP0005464_abnormal_platelet_physiology | 4.70128008 |
| 6 | MP0000749_muscle_degeneration | 4.67417120 |
| 7 | MP0004036_abnormal_muscle_relaxation | 4.54723556 |
| 8 | MP0004215_abnormal_myocardial_fiber | 4.32081181 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 3.88313238 |
| 10 | MP0005330_cardiomyopathy | 3.58236125 |
| 11 | MP0003724_increased_susceptibility_to | 3.43891209 |
| 12 | MP0008004_abnormal_stomach_pH | 3.26633429 |
| 13 | MP0005620_abnormal_muscle_contractility | 3.12045562 |
| 14 | MP0002972_abnormal_cardiac_muscle | 3.09599436 |
| 15 | MP0004087_abnormal_muscle_fiber | 3.05896832 |
| 16 | MP0002106_abnormal_muscle_physiology | 2.95237885 |
| 17 | MP0004484_altered_response_of | 2.92472739 |
| 18 | MP0003303_peritoneal_inflammation | 2.64590328 |
| 19 | MP0000750_abnormal_muscle_regeneration | 2.53045672 |
| 20 | MP0003137_abnormal_impulse_conducting | 2.52473837 |
| 21 | MP0000747_muscle_weakness | 2.47482772 |
| 22 | MP0005369_muscle_phenotype | 2.46219960 |
| 23 | MP0008775_abnormal_heart_ventricle | 2.42042916 |
| 24 | MP0003828_pulmonary_edema | 2.32900997 |
| 25 | MP0001544_abnormal_cardiovascular_syste | 2.29728729 |
| 26 | MP0005385_cardiovascular_system_phenoty | 2.29728729 |
| 27 | MP0002269_muscular_atrophy | 2.28667205 |
| 28 | MP0004130_abnormal_muscle_cell | 2.27047449 |
| 29 | MP0000759_abnormal_skeletal_muscle | 2.26184229 |
| 30 | MP0010630_abnormal_cardiac_muscle | 2.19892305 |
| 31 | MP0004233_abnormal_muscle_weight | 2.11394726 |
| 32 | MP0006138_congestive_heart_failure | 2.07584744 |
| 33 | MP0004510_myositis | 1.99140022 |
| 34 | MP0004085_abnormal_heartbeat | 1.92390827 |
| 35 | MP0003950_abnormal_plasma_membrane | 1.88225870 |
| 36 | MP0003221_abnormal_cardiomyocyte_apopto | 1.80719733 |
| 37 | MP0006036_abnormal_mitochondrial_physio | 1.80334874 |
| 38 | MP0001879_abnormal_lymphatic_vessel | 1.79818804 |
| 39 | MP0002332_abnormal_exercise_endurance | 1.69860131 |
| 40 | MP0002127_abnormal_cardiovascular_syste | 1.59720404 |
| 41 | MP0010368_abnormal_lymphatic_system | 1.52511774 |
| 42 | MP0003436_decreased_susceptibility_to | 1.43640036 |
| 43 | MP0002148_abnormal_hypersensitivity_rea | 1.39100897 |
| 44 | MP0001835_abnormal_antigen_presentation | 1.38697518 |
| 45 | MP0003656_abnormal_erythrocyte_physiolo | 1.38545029 |
| 46 | MP0003879_abnormal_hair_cell | 1.32503246 |
| 47 | MP0002108_abnormal_muscle_morphology | 1.28286067 |
| 48 | MP0000343_altered_response_to | 1.23236896 |
| 49 | MP0000465_gastrointestinal_hemorrhage | 1.22012701 |
| 50 | MP0003567_abnormal_fetal_cardiomyocyte | 1.18650080 |
| 51 | MP0005000_abnormal_immune_tolerance | 1.18139486 |
| 52 | MP0006035_abnormal_mitochondrial_morpho | 1.12395201 |
| 53 | MP0002132_abnormal_respiratory_system | 1.08353296 |
| 54 | MP0009764_decreased_sensitivity_to | 1.08296546 |
| 55 | MP0002419_abnormal_innate_immunity | 1.07469527 |
| 56 | MP0001800_abnormal_humoral_immune | 1.06455644 |
| 57 | MP0005165_increased_susceptibility_to | 1.06159731 |
| 58 | MP0008260_abnormal_autophagy | 1.05425759 |
| 59 | MP0002723_abnormal_immune_serum | 1.04424137 |
| 60 | MP0001533_abnormal_skeleton_physiology | 1.03511795 |
| 61 | MP0009785_altered_susceptibility_to | 1.02287544 |
| 62 | MP0000266_abnormal_heart_morphology | 1.01178378 |
| 63 | MP0001545_abnormal_hematopoietic_system | 1.01104196 |
| 64 | MP0005397_hematopoietic_system_phenotyp | 1.01104196 |
| 65 | MP0008874_decreased_physiological_sensi | 0.92986422 |
| 66 | MP0005166_decreased_susceptibility_to | 0.92050949 |
| 67 | MP0003195_calcinosis | 0.91918517 |
| 68 | MP0003045_fibrosis | 0.91822883 |
| 69 | MP0002452_abnormal_antigen_presenting | 0.91101311 |
| 70 | MP0010155_abnormal_intestine_physiology | 0.90442158 |
| 71 | MP0000230_abnormal_systemic_arterial | 0.89924825 |
| 72 | MP0005410_abnormal_fertilization | 0.88524218 |
| 73 | MP0001790_abnormal_immune_system | 0.87628566 |
| 74 | MP0005387_immune_system_phenotype | 0.87628566 |
| 75 | MP0004147_increased_porphyrin_level | 0.87305761 |
| 76 | MP0003638_abnormal_response/metabolism_ | 0.86958622 |
| 77 | MP0005671_abnormal_response_to | 0.86613135 |
| 78 | MP0003279_aneurysm | 0.85655082 |
| 79 | MP0005025_abnormal_response_to | 0.84399940 |
| 80 | MP0004043_abnormal_pH_regulation | 0.81162345 |
| 81 | MP0008872_abnormal_physiological_respon | 0.80807585 |
| 82 | MP0000013_abnormal_adipose_tissue | 0.80331685 |
| 83 | MP0000733_abnormal_muscle_development | 0.78857817 |
| 84 | MP0005666_abnormal_adipose_tissue | 0.78797512 |
| 85 | MP0009278_abnormal_bone_marrow | 0.78140380 |
| 86 | MP0001851_eye_inflammation | 0.77797676 |
| 87 | MP0005623_abnormal_meninges_morphology | 0.76595836 |
| 88 | MP0000685_abnormal_immune_system | 0.76562292 |
| 89 | MP0002234_abnormal_pharynx_morphology | 0.76417124 |
| 90 | MP0002420_abnormal_adaptive_immunity | 0.75119250 |
| 91 | MP0004947_skin_inflammation | 0.73978666 |
| 92 | MP0001819_abnormal_immune_cell | 0.73697525 |
| 93 | MP0003075_altered_response_to | 0.73215662 |
| 94 | MP0002128_abnormal_blood_circulation | 0.72608345 |
| 95 | MP0005503_abnormal_tendon_morphology | 0.72018233 |
| 96 | MP0002398_abnormal_bone_marrow | 0.71806615 |
| 97 | MP0004272_abnormal_basement_membrane | 0.71219666 |
| 98 | MP0005058_abnormal_lysosome_morphology | 0.71139310 |
| 99 | MP0001845_abnormal_inflammatory_respons | 0.70874941 |
| 100 | MP0005266_abnormal_metabolism | 0.70505601 |
| 101 | MP0005451_abnormal_body_composition | 0.70117959 |
| 102 | MP0002998_abnormal_bone_remodeling | 0.69072753 |
| 103 | MP0005171_absent_coat_pigmentation | 0.67372507 |
| 104 | MP0004883_abnormal_blood_vessel | 0.65413667 |
| 105 | MP0002909_abnormal_adrenal_gland | 0.65043499 |
| 106 | MP0005164_abnormal_response_to | 0.63163410 |
| 107 | MP0005595_abnormal_vascular_smooth | 0.61296562 |
| 108 | MP0004381_abnormal_hair_follicle | 0.61224684 |
| 109 | MP0009763_increased_sensitivity_to | 0.60690441 |
| 110 | MP0005167_abnormal_blood-brain_barrier | 0.58165459 |
| 111 | MP0000767_abnormal_smooth_muscle | 0.57429825 |
| 112 | MP0003122_maternal_imprinting | 0.57106361 |
| 113 | MP0003566_abnormal_cell_adhesion | 0.56989839 |
| 114 | MP0004185_abnormal_adipocyte_glucose | 0.55531445 |
| 115 | MP0005375_adipose_tissue_phenotype | 0.55006143 |
| 116 | MP0001727_abnormal_embryo_implantation | 0.54645694 |
| 117 | MP0009250_abnormal_appendicular_skeleto | 0.53630626 |
| 118 | MP0002295_abnormal_pulmonary_circulatio | 0.52965397 |
| 119 | MP0002971_abnormal_brown_adipose | 0.50307466 |
| 120 | MP0002925_abnormal_cardiovascular_devel | 0.44186969 |
| 121 | MP0000003_abnormal_adipose_tissue | 0.43534094 |
| 122 | MP0000762_abnormal_tongue_morphology | 0.43474594 |
| 123 | MP0008438_abnormal_cutaneous_collagen | 0.42339352 |
| 124 | MP0001440_abnormal_grooming_behavior | 0.40616409 |
| 125 | MP0002133_abnormal_respiratory_system | 0.39288108 |
| 126 | MP0005388_respiratory_system_phenotype | 0.39288108 |
| 127 | MP0005670_abnormal_white_adipose | 0.38648244 |
| 128 | MP0009384_cardiac_valve_regurgitation | 0.37973267 |
| 129 | MP0003948_abnormal_gas_homeostasis | 0.36488423 |
| 130 | MP0001614_abnormal_blood_vessel | 0.35128627 |
| 131 | MP0006054_spinal_hemorrhage | 0.34919393 |
| 132 | MP0001958_emphysema | 0.33980435 |
| 133 | MP0008569_lethality_at_weaning | 0.33159948 |
| 134 | MP0001784_abnormal_fluid_regulation | 0.32836230 |
| 135 | MP0005386_behavior/neurological_phenoty | 0.29822893 |
| 136 | MP0004924_abnormal_behavior | 0.29822893 |
| 137 | MP0009046_muscle_twitch | 0.28749460 |
| 138 | MP0005535_abnormal_body_temperature | 0.28492911 |
| 139 | MP0000249_abnormal_blood_vessel | 0.28376817 |
| 140 | MP0002933_joint_inflammation | 0.27924696 |
| 141 | MP0000372_irregular_coat_pigmentation | 0.27494318 |
| 142 | MP0002078_abnormal_glucose_homeostasis | 0.26764241 |
| 143 | MP0003806_abnormal_nucleotide_metabolis | 0.25978913 |
| 144 | MP0004270_analgesia | 0.25119490 |
| 145 | MP0005083_abnormal_biliary_tract | 0.24071871 |
| 146 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.22193149 |
| 147 | MP0005275_abnormal_skin_tensile | 0.21590397 |
| 148 | MP0004142_abnormal_muscle_tone | 0.19070530 |
| 149 | MP0003385_abnormal_body_wall | 0.18752796 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced muscle cramps (HP:0003710) | 7.83453726 |
| 2 | Exercise-induced myalgia (HP:0003738) | 7.19213734 |
| 3 | Calf muscle hypertrophy (HP:0008981) | 6.90415214 |
| 4 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.85962242 |
| 5 | Sudden death (HP:0001699) | 6.55181190 |
| 6 | Prolonged bleeding time (HP:0003010) | 5.56353567 |
| 7 | Ventricular tachycardia (HP:0004756) | 5.36959329 |
| 8 | Abnormality of the calf musculature (HP:0001430) | 5.22616167 |
| 9 | Muscle fiber splitting (HP:0003555) | 5.16728020 |
| 10 | Hyporeflexia of lower limbs (HP:0002600) | 5.15309248 |
| 11 | Myoglobinuria (HP:0002913) | 5.11285143 |
| 12 | Atrial fibrillation (HP:0005110) | 4.93030753 |
| 13 | EMG: myopathic abnormalities (HP:0003458) | 4.71913260 |
| 14 | Primary atrial arrhythmia (HP:0001692) | 4.59323935 |
| 15 | Menorrhagia (HP:0000132) | 4.58218777 |
| 16 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.57943855 |
| 17 | Subaortic stenosis (HP:0001682) | 4.57943855 |
| 18 | Lipoatrophy (HP:0100578) | 4.57261913 |
| 19 | Muscle fiber inclusion bodies (HP:0100299) | 4.44378720 |
| 20 | Increased mean platelet volume (HP:0011877) | 4.41476775 |
| 21 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.40798566 |
| 22 | Supraventricular tachycardia (HP:0004755) | 4.39196037 |
| 23 | Supraventricular arrhythmia (HP:0005115) | 4.31641061 |
| 24 | Abnormal platelet volume (HP:0011876) | 4.31069787 |
| 25 | Petechiae (HP:0000967) | 4.27441121 |
| 26 | Rhabdomyolysis (HP:0003201) | 4.07936024 |
| 27 | Purpura (HP:0000979) | 3.99617836 |
| 28 | Nemaline bodies (HP:0003798) | 3.93160139 |
| 29 | Acute necrotizing encephalopathy (HP:0006965) | 3.92025776 |
| 30 | Syncope (HP:0001279) | 3.83857226 |
| 31 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.80007487 |
| 32 | Difficulty running (HP:0009046) | 3.77246608 |
| 33 | Muscle stiffness (HP:0003552) | 3.75457471 |
| 34 | Epistaxis (HP:0000421) | 3.68156049 |
| 35 | Dilated cardiomyopathy (HP:0001644) | 3.65412795 |
| 36 | Palpitations (HP:0001962) | 3.65241945 |
| 37 | Right ventricular cardiomyopathy (HP:0011663) | 3.59697732 |
| 38 | Prolonged QT interval (HP:0001657) | 3.58586775 |
| 39 | Asymmetric septal hypertrophy (HP:0001670) | 3.55663553 |
| 40 | Myotonia (HP:0002486) | 3.52109577 |
| 41 | Type 1 muscle fiber predominance (HP:0003803) | 3.50837096 |
| 42 | Bundle branch block (HP:0011710) | 3.49526289 |
| 43 | Increased connective tissue (HP:0009025) | 3.48537095 |
| 44 | Ventricular arrhythmia (HP:0004308) | 3.40739668 |
| 45 | Progressive macrocephaly (HP:0004481) | 3.32214731 |
| 46 | Distal lower limb muscle weakness (HP:0009053) | 3.25372378 |
| 47 | Acute encephalopathy (HP:0006846) | 3.23189031 |
| 48 | Gingival bleeding (HP:0000225) | 3.19623638 |
| 49 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.14575844 |
| 50 | Hyperlipoproteinemia (HP:0010980) | 3.05466595 |
| 51 | Frequent falls (HP:0002359) | 3.02601280 |
| 52 | Paralysis (HP:0003470) | 3.02352320 |
| 53 | Calcaneovalgus deformity (HP:0001848) | 2.97521866 |
| 54 | Areflexia of lower limbs (HP:0002522) | 2.96759926 |
| 55 | Heart block (HP:0012722) | 2.94492569 |
| 56 | Mitochondrial inheritance (HP:0001427) | 2.93382415 |
| 57 | Spontaneous hematomas (HP:0007420) | 2.92420497 |
| 58 | Ventricular fibrillation (HP:0001663) | 2.88560132 |
| 59 | Exercise intolerance (HP:0003546) | 2.86281208 |
| 60 | Neck muscle weakness (HP:0000467) | 2.82295304 |
| 61 | Abnormal atrioventricular conduction (HP:0005150) | 2.80569758 |
| 62 | Hepatic necrosis (HP:0002605) | 2.75232527 |
| 63 | Distal arthrogryposis (HP:0005684) | 2.68994329 |
| 64 | Increased CSF lactate (HP:0002490) | 2.68007627 |
| 65 | Cerebral edema (HP:0002181) | 2.65590906 |
| 66 | Left ventricular hypertrophy (HP:0001712) | 2.65149154 |
| 67 | Abnormal EKG (HP:0003115) | 2.56499089 |
| 68 | Deformed tarsal bones (HP:0008119) | 2.56406327 |
| 69 | Increased variability in muscle fiber diameter (HP:0003557) | 2.56003757 |
| 70 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.53856336 |
| 71 | Atrioventricular block (HP:0001678) | 2.52712550 |
| 72 | Difficulty climbing stairs (HP:0003551) | 2.52343166 |
| 73 | Malignant hyperthermia (HP:0002047) | 2.51680046 |
| 74 | Hepatocellular necrosis (HP:0001404) | 2.51154887 |
| 75 | Round ear (HP:0100830) | 2.49066849 |
| 76 | Weak cry (HP:0001612) | 2.47318079 |
| 77 | Abnormal finger flexion creases (HP:0006143) | 2.46219196 |
| 78 | Congenital malformation of the right heart (HP:0011723) | 2.46160702 |
| 79 | Double outlet right ventricle (HP:0001719) | 2.46160702 |
| 80 | Bulbar palsy (HP:0001283) | 2.41303026 |
| 81 | Abnormality of alanine metabolism (HP:0010916) | 2.39543933 |
| 82 | Hyperalaninemia (HP:0003348) | 2.39543933 |
| 83 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.39543933 |
| 84 | Pheochromocytoma (HP:0002666) | 2.33022112 |
| 85 | Conjunctival hamartoma (HP:0100780) | 2.32169135 |
| 86 | Rimmed vacuoles (HP:0003805) | 2.31233727 |
| 87 | Abnormal platelet function (HP:0011869) | 2.30615158 |
| 88 | Impaired platelet aggregation (HP:0003540) | 2.30615158 |
| 89 | Stomatitis (HP:0010280) | 2.28267471 |
| 90 | Neoplasm of head and neck (HP:0012288) | 2.23884968 |
| 91 | Esophageal neoplasm (HP:0100751) | 2.23884968 |
| 92 | Hypoplastic ischia (HP:0003175) | 2.23607561 |
| 93 | Increased muscle lipid content (HP:0009058) | 2.22624370 |
| 94 | Ragged-red muscle fibers (HP:0003200) | 2.20760106 |
| 95 | Palmoplantar keratoderma (HP:0000982) | 2.18293888 |
| 96 | Hypoglycemic coma (HP:0001325) | 2.18144614 |
| 97 | Respiratory failure (HP:0002878) | 2.17777446 |
| 98 | Neuroendocrine neoplasm (HP:0100634) | 2.16067662 |
| 99 | Lactic acidosis (HP:0003128) | 2.15909530 |
| 100 | Increased intramyocellular lipid droplets (HP:0012240) | 2.11796035 |
| 101 | Muscular dystrophy (HP:0003560) | 2.11441581 |
| 102 | Poikilocytosis (HP:0004447) | 2.10719898 |
| 103 | Distal lower limb amyotrophy (HP:0008944) | 2.10043121 |
| 104 | Generalized muscle weakness (HP:0003324) | 2.09681288 |
| 105 | Abnormal pupillary function (HP:0007686) | 2.09502404 |
| 106 | Increased serum pyruvate (HP:0003542) | 2.08758217 |
| 107 | Abnormality of glycolysis (HP:0004366) | 2.08758217 |
| 108 | Myopathic facies (HP:0002058) | 2.07598490 |
| 109 | Ketoacidosis (HP:0001993) | 2.07498931 |
| 110 | Hyperkalemia (HP:0002153) | 2.01117507 |
| 111 | Fatigable weakness (HP:0003473) | 1.98125710 |
| 112 | Abnormality of the neuromuscular junction (HP:0003398) | 1.98125710 |
| 113 | Dyschromatopsia (HP:0007641) | 1.98004765 |
| 114 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.97372355 |
| 115 | Limb-girdle muscle atrophy (HP:0003797) | 1.96981040 |
| 116 | Abnormality of lateral ventricle (HP:0030047) | 1.95568119 |
| 117 | Hypoplastic left heart (HP:0004383) | 1.94194047 |
| 118 | Abnormality of macrophages (HP:0004311) | 1.94183490 |
| 119 | Optic disc pallor (HP:0000543) | 1.92637856 |
| 120 | Abnormality of the ischium (HP:0003174) | 1.92186757 |
| 121 | Ulnar deviation of the wrist (HP:0003049) | 1.91285411 |
| 122 | EMG: neuropathic changes (HP:0003445) | 1.89678299 |
| 123 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.87102320 |
| 124 | Dicarboxylic aciduria (HP:0003215) | 1.87102320 |
| 125 | Lipid accumulation in hepatocytes (HP:0006561) | 1.86040600 |
| 126 | Chest pain (HP:0100749) | 1.85806665 |
| 127 | Slender build (HP:0001533) | 1.85386288 |
| 128 | Facial diplegia (HP:0001349) | 1.79187438 |
| 129 | Lower limb amyotrophy (HP:0007210) | 1.78070175 |
| 130 | Gowers sign (HP:0003391) | 1.75668006 |
| 131 | Abnormality of the foot musculature (HP:0001436) | 1.74461677 |
| 132 | Waddling gait (HP:0002515) | 1.74075694 |
| 133 | Progressive muscle weakness (HP:0003323) | 1.73300729 |
| 134 | Absent phalangeal crease (HP:0006109) | 1.72344513 |
| 135 | Abnormality of iron homeostasis (HP:0011031) | 1.71428143 |
| 136 | Fetal akinesia sequence (HP:0001989) | 1.70363056 |
| 137 | Bruising susceptibility (HP:0000978) | 1.69841066 |
| 138 | Conjunctival telangiectasia (HP:0000524) | 1.69144054 |
| 139 | Acanthocytosis (HP:0001927) | 1.67899043 |
| 140 | Arterial thrombosis (HP:0004420) | 1.63862766 |
| 141 | Retrobulbar optic neuritis (HP:0100654) | 1.63697265 |
| 142 | Optic neuritis (HP:0100653) | 1.63697265 |
| 143 | Nonprogressive disorder (HP:0003680) | 1.60745064 |
| 144 | Eczematoid dermatitis (HP:0000976) | 1.58928595 |
| 145 | Episodic fever (HP:0001954) | 1.58376503 |
| 146 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.57965604 |
| 147 | Vertigo (HP:0002321) | 1.57786802 |
| 148 | Increased serum ferritin (HP:0003281) | 1.54298344 |
| 149 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.53594982 |
| 150 | Scapular winging (HP:0003691) | 1.53430556 |
| 151 | Orchitis (HP:0100796) | 1.52905090 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 6.06129747 |
| 2 | TTN | 5.29053807 |
| 3 | PHKG1 | 3.98729524 |
| 4 | PHKG2 | 3.98729524 |
| 5 | MYLK | 3.48703020 |
| 6 | PDK3 | 2.85690303 |
| 7 | PDK4 | 2.85690303 |
| 8 | STK24 | 2.79661884 |
| 9 | MST4 | 2.64385468 |
| 10 | LMTK2 | 2.64143298 |
| 11 | DMPK | 2.53269509 |
| 12 | PIK3CA | 2.14183041 |
| 13 | MUSK | 2.12635810 |
| 14 | PDK2 | 2.09671466 |
| 15 | PINK1 | 1.97797013 |
| 16 | BMX | 1.93201512 |
| 17 | NME1 | 1.86937843 |
| 18 | CAMK1G | 1.68860348 |
| 19 | KDR | 1.66296456 |
| 20 | TIE1 | 1.64555581 |
| 21 | TAOK3 | 1.64541059 |
| 22 | CAMK1D | 1.61494143 |
| 23 | GRK7 | 1.59385686 |
| 24 | BTK | 1.48613807 |
| 25 | CAMKK2 | 1.47553175 |
| 26 | WNK4 | 1.44714538 |
| 27 | ZAP70 | 1.42748100 |
| 28 | TEC | 1.42476683 |
| 29 | MAPK12 | 1.42257924 |
| 30 | BCKDK | 1.39865151 |
| 31 | TNK2 | 1.39381642 |
| 32 | ZAK | 1.39286716 |
| 33 | STK38L | 1.32675602 |
| 34 | BLK | 1.31146768 |
| 35 | PKN2 | 1.28296221 |
| 36 | RIPK1 | 1.26560119 |
| 37 | SYK | 1.23105720 |
| 38 | PIK3CG | 1.23049337 |
| 39 | DYRK1B | 1.22687140 |
| 40 | IRAK4 | 1.21932118 |
| 41 | TAOK1 | 1.21891626 |
| 42 | ACVR1B | 1.20613124 |
| 43 | MAP3K7 | 1.18760624 |
| 44 | NEK1 | 1.18329709 |
| 45 | IRAK1 | 1.16954233 |
| 46 | PTK2B | 1.16808465 |
| 47 | CAMK2D | 1.16639430 |
| 48 | MAP2K3 | 1.15282587 |
| 49 | TRPM7 | 1.11404141 |
| 50 | PRPF4B | 1.10111066 |
| 51 | PRKAA2 | 1.08345485 |
| 52 | PAK3 | 1.06978171 |
| 53 | INSRR | 1.04991008 |
| 54 | LIMK1 | 1.04881190 |
| 55 | CDC42BPA | 1.02806565 |
| 56 | IKBKB | 1.01640957 |
| 57 | IRAK2 | 1.00028117 |
| 58 | HCK | 0.99397075 |
| 59 | FGR | 0.98236823 |
| 60 | EIF2AK1 | 0.93055087 |
| 61 | DAPK2 | 0.91669948 |
| 62 | PRKD1 | 0.90631635 |
| 63 | ILK | 0.90377876 |
| 64 | CAMK1 | 0.89016890 |
| 65 | PRKAA1 | 0.88518328 |
| 66 | MAP3K3 | 0.88271309 |
| 67 | STK39 | 0.87522141 |
| 68 | EPHA3 | 0.85747767 |
| 69 | CSF1R | 0.83822303 |
| 70 | ROCK1 | 0.83117560 |
| 71 | MAP3K11 | 0.81417926 |
| 72 | TAOK2 | 0.79858391 |
| 73 | PKN1 | 0.79477642 |
| 74 | WNK1 | 0.79021701 |
| 75 | CAMK4 | 0.78545284 |
| 76 | EPHB1 | 0.76264299 |
| 77 | CSK | 0.76074741 |
| 78 | MAP2K4 | 0.75567125 |
| 79 | MAP3K12 | 0.74558275 |
| 80 | MAP3K1 | 0.74009304 |
| 81 | MAP3K14 | 0.71655459 |
| 82 | TRIB3 | 0.71129049 |
| 83 | GRK6 | 0.70999035 |
| 84 | TXK | 0.70687925 |
| 85 | CAMK2A | 0.69919615 |
| 86 | GRK5 | 0.68015128 |
| 87 | TBK1 | 0.67070705 |
| 88 | MAPKAPK3 | 0.66955776 |
| 89 | SGK3 | 0.65714892 |
| 90 | ROCK2 | 0.63698160 |
| 91 | SIK3 | 0.63571022 |
| 92 | DAPK3 | 0.62282093 |
| 93 | JAK2 | 0.60852636 |
| 94 | MAP2K1 | 0.60118717 |
| 95 | LYN | 0.58759781 |
| 96 | ADRBK2 | 0.58237683 |
| 97 | CAMK2G | 0.57024072 |
| 98 | FRK | 0.56104658 |
| 99 | TYK2 | 0.53851970 |
| 100 | MAP3K5 | 0.52738009 |
| 101 | MAPK7 | 0.52374140 |
| 102 | RIPK4 | 0.50038638 |
| 103 | IKBKE | 0.48953135 |
| 104 | SGK2 | 0.48939079 |
| 105 | TGFBR2 | 0.47993441 |
| 106 | PRKACA | 0.46999892 |
| 107 | PAK6 | 0.45493379 |
| 108 | STK3 | 0.45372347 |
| 109 | NME2 | 0.44315089 |
| 110 | EPHB2 | 0.44285978 |
| 111 | MATK | 0.43798397 |
| 112 | IRAK3 | 0.43171629 |
| 113 | EPHA4 | 0.41859206 |
| 114 | KSR2 | 0.41650851 |
| 115 | PRKG2 | 0.41593354 |
| 116 | MAPK13 | 0.40608538 |
| 117 | PRKG1 | 0.39865600 |
| 118 | MAP3K13 | 0.39500395 |
| 119 | PRKCE | 0.39292801 |
| 120 | PLK2 | 0.38336451 |
| 121 | STK4 | 0.37420365 |
| 122 | AKT2 | 0.37250277 |
| 123 | DYRK1A | 0.37163301 |
| 124 | PRKCQ | 0.35823718 |
| 125 | PAK1 | 0.35356425 |
| 126 | PRKACB | 0.32112981 |
| 127 | JAK3 | 0.31282775 |
| 128 | DYRK3 | 0.31082599 |
| 129 | CAMKK1 | 0.30548194 |
| 130 | JAK1 | 0.29937706 |
| 131 | SGK1 | 0.29050874 |
| 132 | PRKACG | 0.28954032 |
| 133 | MAPK4 | 0.28268089 |
| 134 | PDK1 | 0.27761898 |
| 135 | CCNB1 | 0.26981920 |
| 136 | TNIK | 0.26233887 |
| 137 | MAPK11 | 0.26069176 |
| 138 | ADRBK1 | 0.24975331 |
| 139 | PNCK | 0.24374955 |
| 140 | BMPR2 | 0.24357514 |
| 141 | PDPK1 | 0.22760690 |
| 142 | MAP3K4 | 0.22515587 |
| 143 | MAP2K6 | 0.21313260 |
| 144 | CAMK2B | 0.20159823 |
| 145 | KSR1 | 0.19298318 |
| 146 | MAP3K6 | 0.19166300 |
| 147 | MARK3 | 0.19127281 |
| 148 | LATS2 | 0.16624564 |
| 149 | RAF1 | 0.11599869 |
| 150 | MOS | 0.11441300 |
| 151 | FER | 0.11439984 |
| 152 | RPS6KC1 | 0.11431826 |
| 153 | RPS6KL1 | 0.11431826 |
| 154 | PRKCH | 0.11370835 |
| 155 | RPS6KA3 | 0.11146541 |
| 156 | ERBB3 | 0.11134988 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.85296657 |
| 2 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.80160003 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.41432445 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 4.23542772 |
| 5 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.59071319 |
| 6 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.48848003 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 3.34496161 |
| 8 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.84401725 |
| 9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.83889331 |
| 10 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.83074984 |
| 11 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.76335533 |
| 12 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.54714923 |
| 13 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.17701396 |
| 14 | Carbon metabolism_Homo sapiens_hsa01200 | 1.91260652 |
| 15 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.88976446 |
| 16 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.80244729 |
| 17 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.72661255 |
| 18 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.62576716 |
| 19 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.62115182 |
| 20 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.61555618 |
| 21 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.56933290 |
| 22 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.52667451 |
| 23 | Viral myocarditis_Homo sapiens_hsa05416 | 1.46137076 |
| 24 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.44844153 |
| 25 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.44368547 |
| 26 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.39155248 |
| 27 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.39140962 |
| 28 | Legionellosis_Homo sapiens_hsa05134 | 1.34116564 |
| 29 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.31142094 |
| 30 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.27803140 |
| 31 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.21757495 |
| 32 | Malaria_Homo sapiens_hsa05144 | 1.19696919 |
| 33 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.19527009 |
| 34 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.18033424 |
| 35 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.15173081 |
| 36 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.13881808 |
| 37 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.10358867 |
| 38 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.05748939 |
| 39 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.03371080 |
| 40 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.02014910 |
| 41 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.01930885 |
| 42 | Leishmaniasis_Homo sapiens_hsa05140 | 1.01812394 |
| 43 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.00812029 |
| 44 | Tuberculosis_Homo sapiens_hsa05152 | 0.98446227 |
| 45 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.98160381 |
| 46 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.96276049 |
| 47 | Insulin resistance_Homo sapiens_hsa04931 | 0.95173312 |
| 48 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.91340451 |
| 49 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.89780767 |
| 50 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89047793 |
| 51 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.88167826 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.84676746 |
| 53 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.84245394 |
| 54 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.83563799 |
| 55 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.83339307 |
| 56 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.83106682 |
| 57 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.82438017 |
| 58 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.82389058 |
| 59 | Focal adhesion_Homo sapiens_hsa04510 | 0.81768203 |
| 60 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.77232253 |
| 61 | Renin secretion_Homo sapiens_hsa04924 | 0.76253780 |
| 62 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.75880533 |
| 63 | Circadian entrainment_Homo sapiens_hsa04713 | 0.75634513 |
| 64 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.75474503 |
| 65 | Circadian rhythm_Homo sapiens_hsa04710 | 0.74533388 |
| 66 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.73864728 |
| 67 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.73716830 |
| 68 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.71362609 |
| 69 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.70189348 |
| 70 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.69410334 |
| 71 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.67508647 |
| 72 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.67424401 |
| 73 | Endocytosis_Homo sapiens_hsa04144 | 0.67044809 |
| 74 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.66965500 |
| 75 | Tight junction_Homo sapiens_hsa04530 | 0.66423314 |
| 76 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.66028302 |
| 77 | Galactose metabolism_Homo sapiens_hsa00052 | 0.63323518 |
| 78 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.63200361 |
| 79 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.62864564 |
| 80 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.62110841 |
| 81 | Measles_Homo sapiens_hsa05162 | 0.61527840 |
| 82 | Influenza A_Homo sapiens_hsa05164 | 0.59119032 |
| 83 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.58586337 |
| 84 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.58415895 |
| 85 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.57569974 |
| 86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.53808554 |
| 87 | Taste transduction_Homo sapiens_hsa04742 | 0.53498136 |
| 88 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.53201400 |
| 89 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.52515217 |
| 90 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51641324 |
| 91 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.51537383 |
| 92 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.51363145 |
| 93 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.50771852 |
| 94 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.50724304 |
| 95 | Insulin secretion_Homo sapiens_hsa04911 | 0.50314077 |
| 96 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.49638641 |
| 97 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.49424414 |
| 98 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.48636986 |
| 99 | Shigellosis_Homo sapiens_hsa05131 | 0.48079013 |
| 100 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47286811 |
| 101 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.47120004 |
| 102 | Long-term depression_Homo sapiens_hsa04730 | 0.46849272 |
| 103 | Pertussis_Homo sapiens_hsa05133 | 0.46581628 |
| 104 | Phagosome_Homo sapiens_hsa04145 | 0.46237513 |
| 105 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.45427177 |
| 106 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.45367553 |
| 107 | Glioma_Homo sapiens_hsa05214 | 0.44887041 |
| 108 | Morphine addiction_Homo sapiens_hsa05032 | 0.44179198 |
| 109 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44146223 |
| 110 | Salmonella infection_Homo sapiens_hsa05132 | 0.43244866 |
| 111 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.42050564 |
| 112 | GABAergic synapse_Homo sapiens_hsa04727 | 0.41357479 |
| 113 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.41052828 |
| 114 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.40815787 |
| 115 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.40765911 |
| 116 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.40090823 |
| 117 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.39687538 |
| 118 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.38846004 |
| 119 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.38714431 |
| 120 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.38031316 |
| 121 | Salivary secretion_Homo sapiens_hsa04970 | 0.37569631 |
| 122 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.37400123 |
| 123 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.36755700 |
| 124 | Adherens junction_Homo sapiens_hsa04520 | 0.36501776 |
| 125 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.36476679 |
| 126 | Long-term potentiation_Homo sapiens_hsa04720 | 0.35767759 |
| 127 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.34825298 |
| 128 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.33221216 |
| 129 | Amoebiasis_Homo sapiens_hsa05146 | 0.31734875 |
| 130 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.31323973 |
| 131 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.30715709 |
| 132 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.29032340 |
| 133 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.28964337 |
| 134 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.28950823 |
| 135 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.28660165 |
| 136 | Metabolic pathways_Homo sapiens_hsa01100 | 0.28330303 |
| 137 | Melanogenesis_Homo sapiens_hsa04916 | 0.27971528 |
| 138 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.27623625 |
| 139 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27286622 |
| 140 | Peroxisome_Homo sapiens_hsa04146 | 0.26536298 |
| 141 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.26423096 |
| 142 | Gap junction_Homo sapiens_hsa04540 | 0.26388107 |
| 143 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.26075976 |
| 144 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.24710996 |
| 145 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.24105146 |
| 146 | Platelet activation_Homo sapiens_hsa04611 | 0.23301363 |
| 147 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.20503442 |
| 148 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.19594222 |
| 149 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.19094296 |
| 150 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.18931525 |
| 151 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.18610613 |
| 152 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.16507091 |
| 153 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.14700083 |
| 154 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.12922251 |

