LSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.63201667
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.31622606
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07868076
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07868076
5neutrophil activation involved in immune response (GO:0002283)4.85617255
6positive regulation of gamma-delta T cell activation (GO:0046645)4.85531485
7detection of other organism (GO:0098543)4.79453435
8NIK/NF-kappaB signaling (GO:0038061)4.77517114
9detection of bacterium (GO:0016045)4.74397516
10negative thymic T cell selection (GO:0045060)4.67788499
11regulation of B cell receptor signaling pathway (GO:0050855)4.57452916
12negative T cell selection (GO:0043383)4.52786998
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42014311
14macrophage activation involved in immune response (GO:0002281)4.22469836
15positive regulation of antigen processing and presentation (GO:0002579)4.18732043
16negative regulation of interleukin-12 production (GO:0032695)4.14189413
17immunoglobulin mediated immune response (GO:0016064)4.12522618
18neutrophil activation (GO:0042119)4.11802624
19myeloid dendritic cell activation (GO:0001773)4.10236765
20regulation of interleukin-12 biosynthetic process (GO:0045075)4.09574256
21regulation of dendritic cell antigen processing and presentation (GO:0002604)4.05164521
22myeloid dendritic cell differentiation (GO:0043011)4.01661554
23leukocyte aggregation (GO:0070486)3.97541609
24T cell migration (GO:0072678)3.96570555
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.96133556
26regulation of alpha-beta T cell proliferation (GO:0046640)3.92033665
27cellular response to type I interferon (GO:0071357)3.91686599
28type I interferon signaling pathway (GO:0060337)3.91686599
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.91239435
30regulation of B cell differentiation (GO:0045577)3.89555420
31response to type I interferon (GO:0034340)3.89063338
32granulocyte activation (GO:0036230)3.88173116
33interferon-gamma-mediated signaling pathway (GO:0060333)3.87586356
34detection of external biotic stimulus (GO:0098581)3.85644965
35positive regulation of alpha-beta T cell proliferation (GO:0046641)3.80179622
36cellular response to zinc ion (GO:0071294)3.73459657
37Arp2/3 complex-mediated actin nucleation (GO:0034314)3.73337825
38regulation of antigen processing and presentation (GO:0002577)3.69068482
39negative regulation of leukocyte mediated immunity (GO:0002704)3.62758154
40regulation of T cell tolerance induction (GO:0002664)3.61808240
41response to peptidoglycan (GO:0032494)3.60861710
42negative regulation of T cell mediated immunity (GO:0002710)3.57371946
43positive regulation of interleukin-12 production (GO:0032735)3.57311714
44B cell mediated immunity (GO:0019724)3.55474210
45regulation of T-helper 1 cell differentiation (GO:0045625)3.52953365
46regulation of mast cell degranulation (GO:0043304)3.52553987
47response to host immune response (GO:0052572)3.51068032
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51068032
49positive regulation of interferon-alpha production (GO:0032727)3.43597013
50positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.42290855
51natural killer cell mediated cytotoxicity (GO:0042267)3.42059547
52natural killer cell mediated immunity (GO:0002228)3.42059547
53thymic T cell selection (GO:0045061)3.41334774
54response to muramyl dipeptide (GO:0032495)3.40682675
55sequestering of actin monomers (GO:0042989)3.40489286
56positive regulation of B cell differentiation (GO:0045579)3.40008951
57respiratory burst (GO:0045730)3.38949497
58positive regulation of natural killer cell differentiation (GO:0032825)3.38312363
59regulation of hypersensitivity (GO:0002883)3.37582344
60detection of biotic stimulus (GO:0009595)3.37373564
61defense response to protozoan (GO:0042832)3.36503634
62positive regulation of interleukin-2 production (GO:0032743)3.36495698
63cellular response to interferon-beta (GO:0035458)3.36049996
64B cell receptor signaling pathway (GO:0050853)3.34499469
65regulation of gamma-delta T cell differentiation (GO:0045586)3.33892077
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33564235
67negative regulation of cell killing (GO:0031342)3.33564235
68regulation of gamma-delta T cell activation (GO:0046643)3.30188017
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29679196
70positive regulation of mast cell activation (GO:0033005)3.28084576
71positive T cell selection (GO:0043368)3.26815474
72positive thymic T cell selection (GO:0045059)3.26511724
73T-helper 1 type immune response (GO:0042088)3.26433098
74negative regulation of phagocytosis (GO:0050765)3.25485572
75dendritic cell differentiation (GO:0097028)3.25368961
76detection of molecule of bacterial origin (GO:0032490)3.24534197
77response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23480784
78response to host (GO:0075136)3.23480784
79response to host defenses (GO:0052200)3.23480784
80T cell selection (GO:0045058)3.23394139
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23215565
82regulation of mast cell activation involved in immune response (GO:0033006)3.23106630
83regulation of interferon-alpha production (GO:0032647)3.23061481
84cellular extravasation (GO:0045123)3.21835540
85production of molecular mediator involved in inflammatory response (GO:0002532)3.21158975
86regulation of natural killer cell mediated immunity (GO:0002715)3.20452820
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.20452820
88regulation of RIG-I signaling pathway (GO:0039535)3.19338661
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18534028
90mast cell activation (GO:0045576)3.17287257
91regulation of T cell mediated cytotoxicity (GO:0001914)3.17100150
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16967104
93positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15410204
94regulation of myeloid leukocyte mediated immunity (GO:0002886)3.14621919
95regulation of interleukin-12 production (GO:0032655)3.14351089
96leukocyte degranulation (GO:0043299)3.13970383
97tolerance induction (GO:0002507)3.12820122
98response to protozoan (GO:0001562)3.12305671
99regulation of mast cell activation (GO:0033003)3.12265397
100cellular response to interleukin-15 (GO:0071350)3.11951191
101germinal center formation (GO:0002467)3.11618643
102microglial cell activation (GO:0001774)3.10856843
103natural killer cell activation (GO:0030101)3.09398245
104interferon-gamma production (GO:0032609)3.08993029
105regulation of activation of Janus kinase activity (GO:0010533)3.08896607
106regulation of leukocyte degranulation (GO:0043300)3.08148455
107dendritic cell migration (GO:0036336)3.05397776
108positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05374482
109cellular response to exogenous dsRNA (GO:0071360)3.03886847
110neutrophil mediated immunity (GO:0002446)3.03778160
111response to interferon-beta (GO:0035456)3.03656975
112dendritic cell chemotaxis (GO:0002407)3.03426081
113antigen processing and presentation via MHC class Ib (GO:0002475)3.02590745
114negative regulation of erythrocyte differentiation (GO:0045647)3.02462248
115leukocyte migration involved in inflammatory response (GO:0002523)3.02436424
116natural killer cell differentiation (GO:0001779)3.01071291
117negative regulation of innate immune response (GO:0045824)2.99779523
118myeloid cell activation involved in immune response (GO:0002275)2.99479128
119positive regulation of humoral immune response (GO:0002922)2.99146319
120response to interleukin-15 (GO:0070672)2.98824120
121positive regulation of isotype switching (GO:0045830)2.97429378
122leukocyte mediated cytotoxicity (GO:0001909)2.97368648
123macrophage activation (GO:0042116)2.96883867
124mature B cell differentiation (GO:0002335)2.95832486
125lymphocyte mediated immunity (GO:0002449)2.94924418
126regulation of tolerance induction (GO:0002643)2.93543379
127regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93094752
128positive regulation by symbiont of host defense response (GO:0052509)2.92961041
129modulation by symbiont of host defense response (GO:0052031)2.92961041
130modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92961041
131modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92961041
132positive regulation by organism of defense response of other organism involved in symbiotic interact2.92961041
133modulation by symbiont of host immune response (GO:0052553)2.92961041
134positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.92798175
135T cell costimulation (GO:0031295)2.91656137
136positive regulation of macrophage differentiation (GO:0045651)2.91443445
137cellular response to interferon-gamma (GO:0071346)2.90936251
138regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89987800
139regulation of interferon-beta biosynthetic process (GO:0045357)2.89679388
140positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86839364
141antigen receptor-mediated signaling pathway (GO:0050851)2.86196682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.61718027
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.68996672
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.42688493
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.75785908
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28283997
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.01495608
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.82589760
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.67617319
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.65042419
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.49895243
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24957534
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.20493598
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.11104327
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96493132
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.87540786
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75357428
17MYB_26560356_Chip-Seq_TH2_Human2.57614415
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.52279084
19RUNX_20019798_ChIP-Seq_JUKART_Human2.51143988
20SPI1_23547873_ChIP-Seq_NB4_Human2.48309577
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.42983020
22* MAF_26560356_Chip-Seq_TH1_Human2.40404384
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30487354
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21496509
25MYB_26560356_Chip-Seq_TH1_Human2.18270289
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16238305
27SCL_19346495_ChIP-Seq_HPC-7_Human2.15762322
28VDR_21846776_ChIP-Seq_THP-1_Human2.10788475
29E2F7_22180533_ChIP-Seq_HELA_Human2.06451068
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01841520
31VDR_24763502_ChIP-Seq_THP-1_Human1.99265141
32MYC_22102868_ChIP-Seq_BL_Human1.96025238
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92808045
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.92593041
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92053937
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88991994
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83642045
38UTX_26944678_Chip-Seq_JUKART_Human1.74454629
39* SPI1_23127762_ChIP-Seq_K562_Human1.67208482
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66684688
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64128009
42GATA3_27048872_Chip-Seq_THYMUS_Human1.64065829
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63527435
44PU_27001747_Chip-Seq_BMDM_Mouse1.57397153
45* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56199755
46GATA1_22025678_ChIP-Seq_K562_Human1.48831145
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48527532
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47103224
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46881314
50LXR_22292898_ChIP-Seq_THP-1_Human1.45868108
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44644722
52TCF7_22412390_ChIP-Seq_EML_Mouse1.44034099
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42394397
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40051127
55* MAF_26560356_Chip-Seq_TH2_Human1.39316397
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.39298220
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38721218
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.38369127
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36790910
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35770724
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33764734
62VDR_24787735_ChIP-Seq_THP-1_Human1.33336223
63GATA3_26560356_Chip-Seq_TH2_Human1.29508035
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28617718
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25294851
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21164323
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20401828
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17737685
69BCOR_27268052_Chip-Seq_Bcells_Human1.16941713
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16812466
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16709779
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16153552
73GATA1_19941826_ChIP-Seq_K562_Human1.09341162
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08274000
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07672893
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07573205
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.06073669
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.05911735
79CIITA_25753668_ChIP-Seq_RAJI_Human1.05314108
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05034505
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04771603
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03688396
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01319248
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00947114
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.99714216
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98160661
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97798540
88* KDM2B_26808549_Chip-Seq_DND41_Human0.97296566
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95058204
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.94733698
91CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94710909
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94591804
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93328691
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91875026
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91576927
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90498594
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.89532897
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88031208
99SA1_27219007_Chip-Seq_ERYTHROID_Human0.87630266
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86248136
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81595020
102SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73897664
103EGR1_19032775_ChIP-ChIP_M12_Human0.73227945
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72878713
105SMRT_27268052_Chip-Seq_Bcells_Human0.70150886
106CTCF_26484167_Chip-Seq_Bcells_Mouse0.62677951
107TFEB_21752829_ChIP-Seq_HELA_Human0.62281196
108VDR_23849224_ChIP-Seq_CD4+_Human0.61468147
109* SPI1_20517297_ChIP-Seq_HL60_Human0.61392279
110BCL6_27268052_Chip-Seq_Bcells_Human0.61245024
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59414895
112P300_27268052_Chip-Seq_Bcells_Human0.57956099
113ELK1_19687146_ChIP-ChIP_HELA_Human0.57638492
114NCOR1_26117541_ChIP-Seq_K562_Human0.56922633
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.56743044
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56673032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.64054958
2MP0005671_abnormal_response_to3.81106872
3* MP0000685_abnormal_immune_system3.71557582
4MP0009785_altered_susceptibility_to3.54766859
5MP0002148_abnormal_hypersensitivity_rea3.48712580
6MP0001790_abnormal_immune_system3.48550121
7MP0005387_immune_system_phenotype3.48550121
8MP0003436_decreased_susceptibility_to3.35474412
9MP0005000_abnormal_immune_tolerance3.17033938
10MP0001800_abnormal_humoral_immune3.13078864
11MP0002452_abnormal_antigen_presenting2.94714886
12MP0005025_abnormal_response_to2.93265712
13MP0002166_altered_tumor_susceptibility2.87105680
14MP0002723_abnormal_immune_serum2.80254099
15* MP0001819_abnormal_immune_cell2.70290623
16* MP0002420_abnormal_adaptive_immunity2.68398856
17* MP0002419_abnormal_innate_immunity2.67835762
18MP0004510_myositis2.65183476
19MP0002006_tumorigenesis2.52157967
20MP0003763_abnormal_thymus_physiology2.52142351
21MP0002138_abnormal_hepatobiliary_system2.43228523
22MP0006082_CNS_inflammation2.33372726
23* MP0002398_abnormal_bone_marrow2.22086697
24* MP0000716_abnormal_immune_system2.15163735
25MP0002405_respiratory_system_inflammati2.14375872
26MP0001853_heart_inflammation2.05121560
27MP0001348_abnormal_lacrimal_gland1.95356286
28MP0003303_peritoneal_inflammation1.94855420
29MP0003724_increased_susceptibility_to1.94308217
30MP0005310_abnormal_salivary_gland1.90650393
31MP0010155_abnormal_intestine_physiology1.82988662
32MP0005464_abnormal_platelet_physiology1.80823112
33MP0001845_abnormal_inflammatory_respons1.78946691
34MP0009333_abnormal_splenocyte_physiolog1.75916861
35MP0004947_skin_inflammation1.73623382
36MP0000689_abnormal_spleen_morphology1.73512332
37MP0001873_stomach_inflammation1.73360666
38* MP0002429_abnormal_blood_cell1.73343506
39MP0002722_abnormal_immune_system1.70655820
40MP0002396_abnormal_hematopoietic_system1.67034682
41MP0002163_abnormal_gland_morphology1.65444513
42MP0002009_preneoplasia1.61429939
43MP0005451_abnormal_body_composition1.50060939
44MP0001533_abnormal_skeleton_physiology1.50059045
45MP0002933_joint_inflammation1.48020051
46MP0008260_abnormal_autophagy1.45067579
47MP0008469_abnormal_protein_level1.41482447
48MP0003448_altered_tumor_morphology1.37075303
49MP0000703_abnormal_thymus_morphology1.36628051
50MP0000858_altered_metastatic_potential1.34205559
51MP0009764_decreased_sensitivity_to1.31121364
52MP0005397_hematopoietic_system_phenotyp1.27692972
53MP0001545_abnormal_hematopoietic_system1.27692972
54MP0004808_abnormal_hematopoietic_stem1.22902288
55MP0004381_abnormal_hair_follicle1.16635320
56MP0002254_reproductive_system_inflammat1.15728649
57MP0005058_abnormal_lysosome_morphology1.13618490
58MP0004883_abnormal_blood_vessel1.11068400
59MP0005174_abnormal_tail_pigmentation1.10833702
60MP0003300_gastrointestinal_ulcer1.08946768
61MP0003866_abnormal_defecation1.08722576
62MP0002998_abnormal_bone_remodeling1.08159851
63MP0009278_abnormal_bone_marrow1.02141727
64MP0003806_abnormal_nucleotide_metabolis0.94729553
65MP0005379_endocrine/exocrine_gland_phen0.93646892
66MP0002277_abnormal_respiratory_mucosa0.92380183
67MP0000604_amyloidosis0.92242278
68MP0000343_altered_response_to0.92041494
69MP0000569_abnormal_digit_pigmentation0.91655489
70MP0003690_abnormal_glial_cell0.90730806
71MP0005076_abnormal_cell_differentiation0.89455650
72MP0008057_abnormal_DNA_replication0.88582393
73MP0000490_abnormal_crypts_of0.88014786
74MP0005164_abnormal_response_to0.82559484
75MP0002877_abnormal_melanocyte_morpholog0.78727738
76MP0009840_abnormal_foam_cell0.78244716
77MP0002019_abnormal_tumor_incidence0.78097703
78MP0001346_abnormal_lacrimal_gland0.76846740
79MP0003828_pulmonary_edema0.76553835
80MP0003183_abnormal_peptide_metabolism0.76428114
81MP0000465_gastrointestinal_hemorrhage0.76084422
82MP0002132_abnormal_respiratory_system0.73991041
83MP0005390_skeleton_phenotype0.72991061
84MP0003075_altered_response_to0.71635239
85MP0009763_increased_sensitivity_to0.71468279
86MP0000249_abnormal_blood_vessel0.69888438
87MP0003172_abnormal_lysosome_physiology0.68676699
88MP0001986_abnormal_taste_sensitivity0.68167378
89MP0002876_abnormal_thyroid_physiology0.66356722
90MP0006054_spinal_hemorrhage0.65680518
91MP0009765_abnormal_xenobiotic_induced0.65371190
92MP0008004_abnormal_stomach_pH0.64931794
93MP0001851_eye_inflammation0.64925905
94MP0003191_abnormal_cellular_cholesterol0.64056977
95MP0008874_decreased_physiological_sensi0.62152706
96MP0010307_abnormal_tumor_latency0.61670909
97MP0005166_decreased_susceptibility_to0.58852580
98MP0000371_diluted_coat_color0.58040694
99MP0010352_gastrointestinal_tract_polyps0.57359279
100MP0003091_abnormal_cell_migration0.57317563
101MP0003656_abnormal_erythrocyte_physiolo0.56743575
102MP0003795_abnormal_bone_structure0.56248774
103MP0003045_fibrosis0.56136374
104MP0003453_abnormal_keratinocyte_physiol0.56112501
105MP0003566_abnormal_cell_adhesion0.55480042
106MP0002095_abnormal_skin_pigmentation0.55332194
107MP0000015_abnormal_ear_pigmentation0.55160670
108MP0002136_abnormal_kidney_physiology0.53667874
109MP0000767_abnormal_smooth_muscle0.52643293
110MP0005319_abnormal_enzyme/_coenzyme0.52338565
111MP0002693_abnormal_pancreas_physiology0.51809990
112MP0008007_abnormal_cellular_replicative0.50237574
113MP0001243_abnormal_dermal_layer0.49267082
114MP0005075_abnormal_melanosome_morpholog0.47464434
115MP0001881_abnormal_mammary_gland0.45372623
116MP0000609_abnormal_liver_physiology0.45262074
117MP0001663_abnormal_digestive_system0.44942196
118MP0000920_abnormal_myelination0.44531154
119MP0004130_abnormal_muscle_cell0.43658651
120MP0005381_digestive/alimentary_phenotyp0.43215169
121MP0005584_abnormal_enzyme/coenzyme_acti0.38765576
122MP0005376_homeostasis/metabolism_phenot0.36477313

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.36941287
2Recurrent bacterial skin infections (HP:0005406)6.07364846
3Eczematoid dermatitis (HP:0000976)5.93714665
4Elevated erythrocyte sedimentation rate (HP:0003565)5.51072508
5Myositis (HP:0100614)5.17568194
6Retrobulbar optic neuritis (HP:0100654)4.65434922
7Optic neuritis (HP:0100653)4.65434922
8Recurrent fungal infections (HP:0002841)4.63354273
9Orchitis (HP:0100796)4.46471276
10Recurrent viral infections (HP:0004429)4.27997591
11Recurrent skin infections (HP:0001581)4.20736067
12Recurrent gram-negative bacterial infections (HP:0005420)4.17653228
13Mediastinal lymphadenopathy (HP:0100721)4.11143448
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.07317947
15Increased IgM level (HP:0003496)4.04677177
16Chronic otitis media (HP:0000389)3.94652903
17Chronic mucocutaneous candidiasis (HP:0002728)3.81602384
18Recurrent cutaneous fungal infections (HP:0011370)3.81602384
19Abnormality of macrophages (HP:0004311)3.80608325
20Vasculitis (HP:0002633)3.79092846
21Autoimmune thrombocytopenia (HP:0001973)3.74249831
22Abnormality of T cell number (HP:0011839)3.69189952
23Agammaglobulinemia (HP:0004432)3.67429445
24Meningitis (HP:0001287)3.64837004
25Obstructive lung disease (HP:0006536)3.50792720
26Chronic obstructive pulmonary disease (HP:0006510)3.50792720
27Gastrointestinal infarctions (HP:0005244)3.50230924
28Recurrent bronchitis (HP:0002837)3.47155445
29Thrombocytosis (HP:0001894)3.37671568
30Panhypogammaglobulinemia (HP:0003139)3.36109601
31Cellulitis (HP:0100658)3.32145664
32T lymphocytopenia (HP:0005403)3.22324264
33IgM deficiency (HP:0002850)3.19957742
34Pulmonary infiltrates (HP:0002113)3.17075196
35Abnormality of T cells (HP:0002843)3.14498131
36Keratoconjunctivitis sicca (HP:0001097)3.11347116
37Gingivitis (HP:0000230)3.10471811
38Arterial thrombosis (HP:0004420)3.07510351
39Leukocytosis (HP:0001974)3.02299495
40Hypergammaglobulinemia (HP:0010702)2.96035441
41Nasal polyposis (HP:0100582)2.95227547
42Stomatitis (HP:0010280)2.94227696
43Abnormality of T cell physiology (HP:0011840)2.94037584
44Prolonged bleeding time (HP:0003010)2.91541262
45Inflammation of the large intestine (HP:0002037)2.91251038
46Colitis (HP:0002583)2.91167333
47Abnormality of liposaccharide metabolism (HP:0010968)2.89783506
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.89783506
49Abnormality of glycolipid metabolism (HP:0010969)2.89783506
50Encephalitis (HP:0002383)2.87913967
51Keratoconjunctivitis (HP:0001096)2.86891269
52Eosinophilia (HP:0001880)2.85401112
53Hypochromic microcytic anemia (HP:0004840)2.81019643
54IgG deficiency (HP:0004315)2.79977440
55Hemoptysis (HP:0002105)2.79904594
56Gastrointestinal inflammation (HP:0004386)2.79776426
57Pustule (HP:0200039)2.79746051
58Thyroiditis (HP:0100646)2.75555549
59Hypochromic anemia (HP:0001931)2.74447435
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.69605842
61Interstitial pulmonary disease (HP:0006530)2.68180779
62Spontaneous hematomas (HP:0007420)2.66734755
63Abnormality of the nasal mucosa (HP:0000433)2.63950871
64Autoimmune hemolytic anemia (HP:0001890)2.62731778
65Abnormality of eosinophils (HP:0001879)2.59676971
66Severe combined immunodeficiency (HP:0004430)2.59159898
67Recurrent pneumonia (HP:0006532)2.58868192
68Lymphopenia (HP:0001888)2.56848670
69Episodic fever (HP:0001954)2.56435168
70Basal ganglia calcification (HP:0002135)2.54491419
71Granulocytopenia (HP:0001913)2.54094433
72Recurrent lower respiratory tract infections (HP:0002783)2.51578996
73Urticaria (HP:0001025)2.51200509
74Pulmonary embolism (HP:0002204)2.49601083
75Periodontitis (HP:0000704)2.49195388
76Combined immunodeficiency (HP:0005387)2.47967704
77Increased IgE level (HP:0003212)2.42254809
78Spinal cord lesions (HP:0100561)2.40347338
79Syringomyelia (HP:0003396)2.40347338
80Systemic lupus erythematosus (HP:0002725)2.39189507
81Anorexia (HP:0002039)2.39071151
82Purpura (HP:0000979)2.37455602
83Chest pain (HP:0100749)2.35628407
84Petechiae (HP:0000967)2.35014380
85Vacuolated lymphocytes (HP:0001922)2.32924779
86Chronic diarrhea (HP:0002028)2.31020731
87Gastrointestinal stroma tumor (HP:0100723)2.30169629
88Hepatosplenomegaly (HP:0001433)2.29975927
89Peritonitis (HP:0002586)2.29016882
90Verrucae (HP:0200043)2.26101561
91Papilloma (HP:0012740)2.26101561
92Osteomyelitis (HP:0002754)2.26080501
93Absent frontal sinuses (HP:0002688)2.25449618
94Gangrene (HP:0100758)2.24390273
95Hematochezia (HP:0002573)2.23901222
96Gingival bleeding (HP:0000225)2.20083631
97Amyloidosis (HP:0011034)2.19708602
98Fatigue (HP:0012378)2.18053605
99Chronic sinusitis (HP:0011109)2.17329814
100IgA deficiency (HP:0002720)2.16867535
101Loss of speech (HP:0002371)2.16480067
102Microcytic anemia (HP:0001935)2.15314161
103Emphysema (HP:0002097)2.15297565
104Joint swelling (HP:0001386)2.14890071
105Prostate neoplasm (HP:0100787)2.12932784
106Increased neuronal autofluorescent lipopigment (HP:0002074)2.12266149
107Restrictive lung disease (HP:0002091)2.12238636
108Premature loss of primary teeth (HP:0006323)2.12014691
109Abnormality of the prostate (HP:0008775)2.11243395
110Dysostosis multiplex (HP:0000943)2.09562233
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09373991
112Skin rash (HP:0000988)2.09043930
113Glomerulopathy (HP:0100820)2.06227456
114Skin ulcer (HP:0200042)2.05975075
115Recurrent sinusitis (HP:0011108)2.04722187
116Sepsis (HP:0100806)2.04632471
117Abnormality of the pleura (HP:0002103)2.03634354
118Abnormality of the peritoneum (HP:0002585)2.02045998
119Increased serum ferritin (HP:0003281)2.01348656
120Agnosia (HP:0010524)1.99235534
121Arthralgia (HP:0002829)1.98113400
122Increased cerebral lipofuscin (HP:0011813)1.97945183
123Epistaxis (HP:0000421)1.96018603
124Abnormality of the fingertips (HP:0001211)1.95526983
125Polyneuropathy (HP:0001271)1.94268097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.43282751
2MAP3K144.39928114
3TYK23.39317932
4JAK33.37882477
5IRAK43.28431760
6TBK13.10969096
7IKBKB2.75388745
8BLK2.69909803
9TXK2.64545912
10IKBKE2.61564840
11PRPF4B2.41100284
12KIT2.35029172
13TNK22.27505710
14MAP3K132.26674301
15RIPK42.22520147
16ZAP702.16853293
17BTK2.06836380
18CSF1R2.05626609
19JAK12.03427354
20SYK1.93843346
21IRAK31.87700439
22CHUK1.81660287
23MAP3K111.80004263
24STK101.75773127
25FLT31.72047935
26TEC1.70287281
27PIM21.66679094
28CSK1.65160300
29TAOK11.50463858
30LCK1.41936105
31MAP3K31.39130019
32EPHB11.30444966
33ITK1.30344319
34FGFR41.28681086
35HCK1.28334487
36LRRK21.25315056
37PIM11.25029833
38NME21.24441121
39LYN1.20056475
40TAOK31.19905157
41NEK91.18686791
42FGFR31.11153218
43GRK61.09188127
44MST41.08467415
45MAP3K11.05894329
46NLK1.03882016
47KDR1.03089327
48RPS6KA41.02462973
49TAOK20.97697628
50CLK10.97058559
51FES0.92824819
52TGFBR20.91117801
53TESK20.88940408
54SMG10.88658493
55ERN10.85456826
56JAK20.83351762
57SIK30.83088885
58BMPR20.83053870
59PRKCQ0.82309371
60STK40.82189764
61MAP3K120.77008821
62PRKD20.76978108
63MAPK120.76130550
64KSR20.75703987
65MARK20.74947921
66STK240.69194625
67ACVR1B0.68787540
68GRK70.67770172
69CDC42BPA0.67623999
70MAP3K100.66866179
71FYN0.64456843
72CDK190.64213456
73MARK30.63745150
74MAP2K30.62106014
75PDPK10.61845822
76PRKCD0.60186274
77MAPK70.59537524
78PIK3CG0.59532036
79EPHA30.58174769
80TGFBR10.55967281
81TTN0.54806698
82FGR0.54574935
83CAMKK10.54041937
84TRPM70.53346130
85ABL10.53183458
86EIF2AK20.51534598
87HIPK20.51317589
88TRIB30.50873309
89TESK10.50567500
90IRAK20.49254391
91ARAF0.49127149
92MAP3K80.48866305
93MAP3K70.48694130
94IRAK10.47319460
95RPS6KA60.46632489
96SIK20.46197282
97ADRBK20.45015140
98MAP3K50.44164854
99* MAPKAPK20.41699226
100CAMKK20.41499639
101CDK90.40227051
102SIK10.37666699
103CDK40.37595440
104PTK60.36449582
105STK110.35153949
106MATK0.34950241
107MOS0.34740525
108RAF10.34293876
109YES10.34090134
110PRKCH0.33874940
111CDK60.33561718
112PKN10.32676485
113PTK2B0.32437960
114MAP3K60.31482689
115MAPK110.30529049
116DYRK1B0.30239514
117RPS6KC10.30057134
118RPS6KL10.30057134
119MAP2K20.29385914
120TLK10.28845629
121EGFR0.28420827
122RPS6KA50.25934439
123NUAK10.25704844
124MYLK0.25029397
125BMPR1B0.24558949
126BCKDK0.23629838
127PDK10.23174278
128MAPK40.22909386
129CDK120.22793016
130MAP2K60.22710251
131ABL20.22253324
132ILK0.21111395

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.51397598
2Allograft rejection_Homo sapiens_hsa053303.29784822
3Primary immunodeficiency_Homo sapiens_hsa053403.23598967
4Leishmaniasis_Homo sapiens_hsa051403.06498929
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.91807246
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.89732646
7Measles_Homo sapiens_hsa051622.54150753
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41633517
9Antigen processing and presentation_Homo sapiens_hsa046122.36968822
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28906254
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24798984
12Osteoclast differentiation_Homo sapiens_hsa043802.22524983
13B cell receptor signaling pathway_Homo sapiens_hsa046622.15065466
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11288478
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09499850
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96320060
17Autoimmune thyroid disease_Homo sapiens_hsa053201.93632739
18Herpes simplex infection_Homo sapiens_hsa051681.87202126
19Viral myocarditis_Homo sapiens_hsa054161.81506384
20Legionellosis_Homo sapiens_hsa051341.77892497
21Toxoplasmosis_Homo sapiens_hsa051451.75671235
22Influenza A_Homo sapiens_hsa051641.70375768
23Type I diabetes mellitus_Homo sapiens_hsa049401.69991690
24Pertussis_Homo sapiens_hsa051331.69638922
25T cell receptor signaling pathway_Homo sapiens_hsa046601.67441767
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.65406127
27Hematopoietic cell lineage_Homo sapiens_hsa046401.65205896
28Chemokine signaling pathway_Homo sapiens_hsa040621.65200689
29Shigellosis_Homo sapiens_hsa051311.64778451
30TNF signaling pathway_Homo sapiens_hsa046681.60806472
31Staphylococcus aureus infection_Homo sapiens_hsa051501.57159885
32Malaria_Homo sapiens_hsa051441.53526566
33* Tuberculosis_Homo sapiens_hsa051521.51765719
34Apoptosis_Homo sapiens_hsa042101.49845502
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47526499
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44128411
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36038290
38Salmonella infection_Homo sapiens_hsa051321.34995953
39Hepatitis B_Homo sapiens_hsa051611.22547692
40Asthma_Homo sapiens_hsa053101.21445023
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.20028968
42Rheumatoid arthritis_Homo sapiens_hsa053231.18466174
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10592251
44Acute myeloid leukemia_Homo sapiens_hsa052211.10048040
45African trypanosomiasis_Homo sapiens_hsa051431.07938756
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05956295
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03749947
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00305103
49Epstein-Barr virus infection_Homo sapiens_hsa051690.96402593
50Other glycan degradation_Homo sapiens_hsa005110.94676107
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88986287
52Hepatitis C_Homo sapiens_hsa051600.87188813
53Pancreatic cancer_Homo sapiens_hsa052120.86492609
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86209486
55Platelet activation_Homo sapiens_hsa046110.85049744
56Chronic myeloid leukemia_Homo sapiens_hsa052200.82353648
57Lysosome_Homo sapiens_hsa041420.79274038
58Viral carcinogenesis_Homo sapiens_hsa052030.70388840
59p53 signaling pathway_Homo sapiens_hsa041150.69284284
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.68714265
61HTLV-I infection_Homo sapiens_hsa051660.68682067
62Phagosome_Homo sapiens_hsa041450.68086889
63Prolactin signaling pathway_Homo sapiens_hsa049170.65695364
64Small cell lung cancer_Homo sapiens_hsa052220.61479279
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60854969
66Proteasome_Homo sapiens_hsa030500.59184952
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.57640567
68Base excision repair_Homo sapiens_hsa034100.54354180
69Ribosome_Homo sapiens_hsa030100.49417744
70DNA replication_Homo sapiens_hsa030300.49282189
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49190094
72Amoebiasis_Homo sapiens_hsa051460.44964663
73Renal cell carcinoma_Homo sapiens_hsa052110.44807997
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44560826
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44153488
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.43920470
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43908301
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42812600
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42793798
80VEGF signaling pathway_Homo sapiens_hsa043700.41092852
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37475981
82Non-small cell lung cancer_Homo sapiens_hsa052230.36884284
83Choline metabolism in cancer_Homo sapiens_hsa052310.32316467
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31887702
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31338552
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30878892
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.30864202
88GnRH signaling pathway_Homo sapiens_hsa049120.30776016
89Colorectal cancer_Homo sapiens_hsa052100.30602710
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.28774352
91Endocytosis_Homo sapiens_hsa041440.28661146
92Homologous recombination_Homo sapiens_hsa034400.26833109
93HIF-1 signaling pathway_Homo sapiens_hsa040660.26254688
94Notch signaling pathway_Homo sapiens_hsa043300.25818976
95Endometrial cancer_Homo sapiens_hsa052130.25718478
96Non-homologous end-joining_Homo sapiens_hsa034500.25683615
97Mismatch repair_Homo sapiens_hsa034300.25322544
98mTOR signaling pathway_Homo sapiens_hsa041500.25138415
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.24119213
100Regulation of autophagy_Homo sapiens_hsa041400.24038928
101Collecting duct acid secretion_Homo sapiens_hsa049660.22911174
102MAPK signaling pathway_Homo sapiens_hsa040100.22653129
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22485839
104Adherens junction_Homo sapiens_hsa045200.22354840
105Rap1 signaling pathway_Homo sapiens_hsa040150.22249465
106FoxO signaling pathway_Homo sapiens_hsa040680.21727946
107Pathways in cancer_Homo sapiens_hsa052000.21180146
108Systemic lupus erythematosus_Homo sapiens_hsa053220.20672864
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20554737
110Insulin resistance_Homo sapiens_hsa049310.20108400
111Type II diabetes mellitus_Homo sapiens_hsa049300.19750929
112Proteoglycans in cancer_Homo sapiens_hsa052050.19003988
113MicroRNAs in cancer_Homo sapiens_hsa052060.18544786
114Prostate cancer_Homo sapiens_hsa052150.15261402
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13646472
116Focal adhesion_Homo sapiens_hsa045100.11162315
117Inositol phosphate metabolism_Homo sapiens_hsa005620.11120355

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