LSS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cholesterol biosynthetic process (GO:0006695)9.45028358
2fatty acid elongation (GO:0030497)8.58585690
3* sterol biosynthetic process (GO:0016126)8.28413668
4long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.74230301
5isoprenoid biosynthetic process (GO:0008299)6.56293625
6axon ensheathment in central nervous system (GO:0032291)6.45045160
7central nervous system myelination (GO:0022010)6.45045160
8fatty-acyl-CoA biosynthetic process (GO:0046949)6.27104890
9long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.61938503
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.57603914
11L-phenylalanine catabolic process (GO:0006559)5.57603914
12thioester biosynthetic process (GO:0035384)5.28839398
13acyl-CoA biosynthetic process (GO:0071616)5.28839398
14alpha-linolenic acid metabolic process (GO:0036109)5.21883412
15fatty-acyl-CoA metabolic process (GO:0035337)5.09855818
16L-phenylalanine metabolic process (GO:0006558)4.94197220
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.94197220
18* cholesterol metabolic process (GO:0008203)4.78273473
19very long-chain fatty acid metabolic process (GO:0000038)4.77817899
20response to lipoprotein particle (GO:0055094)4.71831485
21acetyl-CoA metabolic process (GO:0006084)4.65757741
22* sterol metabolic process (GO:0016125)4.40602488
23response to methylmercury (GO:0051597)4.37439370
24axon ensheathment (GO:0008366)4.30642398
25ensheathment of neurons (GO:0007272)4.30642398
26L-serine metabolic process (GO:0006563)4.28764958
27* steroid biosynthetic process (GO:0006694)4.24271996
28myelination (GO:0042552)4.22569907
29long-chain fatty acid biosynthetic process (GO:0042759)4.21702761
30cellular response to cholesterol (GO:0071397)4.17752510
31aromatic amino acid family catabolic process (GO:0009074)4.16604426
32glyoxylate metabolic process (GO:0046487)4.07347109
33bile acid biosynthetic process (GO:0006699)4.01021632
34acyl-CoA metabolic process (GO:0006637)4.00494347
35thioester metabolic process (GO:0035383)4.00494347
36coenzyme catabolic process (GO:0009109)3.88982005
37plasma lipoprotein particle clearance (GO:0034381)3.85556968
38tyrosine metabolic process (GO:0006570)3.78649251
39regulation of cholesterol homeostasis (GO:2000188)3.73809530
40Golgi transport vesicle coating (GO:0048200)3.72969287
41COPI coating of Golgi vesicle (GO:0048205)3.72969287
42intestinal cholesterol absorption (GO:0030299)3.72877207
43protein retention in ER lumen (GO:0006621)3.68507640
44regulation of cholesterol biosynthetic process (GO:0045540)3.68424669
45* alcohol biosynthetic process (GO:0046165)3.66449244
46heme transport (GO:0015886)3.65692951
47pyrimidine nucleobase catabolic process (GO:0006208)3.61428920
48regulation of early endosome to late endosome transport (GO:2000641)3.60608264
49triglyceride biosynthetic process (GO:0019432)3.57677761
50very-low-density lipoprotein particle assembly (GO:0034379)3.57382557
51serine family amino acid biosynthetic process (GO:0009070)3.56565112
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.53262855
53coenzyme A metabolic process (GO:0015936)3.50276787
54regulation of NFAT protein import into nucleus (GO:0051532)3.49962417
55planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49869896
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.49626624
57acylglycerol biosynthetic process (GO:0046463)3.47234376
58neutral lipid biosynthetic process (GO:0046460)3.47234376
59cellular response to sterol (GO:0036315)3.45804947
60ethanol oxidation (GO:0006069)3.43225672
61negative regulation of fibrinolysis (GO:0051918)3.42085399
62semaphorin-plexin signaling pathway (GO:0071526)3.41156520
63amyloid precursor protein metabolic process (GO:0042982)3.41087569
64bile acid metabolic process (GO:0008206)3.37906202
65basement membrane organization (GO:0071711)3.37095872
66linoleic acid metabolic process (GO:0043651)3.34076306
67high-density lipoprotein particle remodeling (GO:0034375)3.31602603
68glycerophospholipid catabolic process (GO:0046475)3.30493392
69protein carboxylation (GO:0018214)3.28328279
70peptidyl-glutamic acid carboxylation (GO:0017187)3.28328279
71cytoskeletal anchoring at plasma membrane (GO:0007016)3.26575390
72ethanol metabolic process (GO:0006067)3.25379088
73cofactor catabolic process (GO:0051187)3.24267792
74aldehyde catabolic process (GO:0046185)3.24220891
75establishment of mitochondrion localization (GO:0051654)3.24180741
76regulation of lipoprotein metabolic process (GO:0050746)3.23306035
77low-density lipoprotein particle clearance (GO:0034383)3.23025292
78protein localization to endosome (GO:0036010)3.22794520
79amyloid precursor protein catabolic process (GO:0042987)3.22525523
80retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.21318853
81cysteine metabolic process (GO:0006534)3.20870060
82adherens junction assembly (GO:0034333)3.20143921
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18350299
84regulation of fibrinolysis (GO:0051917)3.17826861
85sulfur amino acid catabolic process (GO:0000098)3.15549516
86regulation of cholesterol storage (GO:0010885)3.15318408
87aromatic amino acid family metabolic process (GO:0009072)3.14399537
88urea metabolic process (GO:0019627)3.11373569
89urea cycle (GO:0000050)3.11373569
90* steroid metabolic process (GO:0008202)3.07992114
91positive regulation of cellular amine metabolic process (GO:0033240)3.07932586
92terpenoid biosynthetic process (GO:0016114)3.07824491
93layer formation in cerebral cortex (GO:0021819)3.07630988
94regulation of glucose import in response to insulin stimulus (GO:2001273)3.06433933
95cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.05766784
96regulation of cholesterol metabolic process (GO:0090181)3.05594391
97cholesterol efflux (GO:0033344)3.03336852
98focal adhesion assembly (GO:0048041)3.03016677
99cell-substrate adherens junction assembly (GO:0007045)3.03016677
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02037869
101myelin maintenance (GO:0043217)3.00141109
102estrogen biosynthetic process (GO:0006703)2.99288543
103response to cholesterol (GO:0070723)2.98884130
104regulation of collateral sprouting (GO:0048670)2.97950510
105proline biosynthetic process (GO:0006561)2.96968896
106negative regulation of fatty acid transport (GO:2000192)2.96034932
107response to phenylpropanoid (GO:0080184)2.95746669
108apical protein localization (GO:0045176)2.95180175
109* organic hydroxy compound biosynthetic process (GO:1901617)2.95135120
110regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95055252
111negative regulation of sterol transport (GO:0032372)2.93773447
112negative regulation of cholesterol transport (GO:0032375)2.93773447
113short-chain fatty acid metabolic process (GO:0046459)2.93623438
114indolalkylamine catabolic process (GO:0046218)2.93351598
115tryptophan catabolic process (GO:0006569)2.93351598
116indole-containing compound catabolic process (GO:0042436)2.93351598
117kynurenine metabolic process (GO:0070189)2.92748455
118iron coordination entity transport (GO:1901678)2.89355489
119regulation of plasminogen activation (GO:0010755)2.87136168
120serine family amino acid metabolic process (GO:0009069)2.85263544
121tryptophan metabolic process (GO:0006568)2.85249171
122cell-cell junction maintenance (GO:0045217)2.84894093
123cellular ketone body metabolic process (GO:0046950)2.84798217
124epithelial cell-cell adhesion (GO:0090136)2.83051680
125reverse cholesterol transport (GO:0043691)2.82798890
126plasma lipoprotein particle assembly (GO:0034377)2.82537481
127dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81604954
128protein-lipid complex assembly (GO:0065005)2.80705063
129cell-substrate junction assembly (GO:0007044)2.79252980
130regulation of apoptotic cell clearance (GO:2000425)2.78291082
131proline metabolic process (GO:0006560)2.74129978
132glucose 6-phosphate metabolic process (GO:0051156)2.71446353
133dicarboxylic acid biosynthetic process (GO:0043650)2.70242356
134adhesion of symbiont to host (GO:0044406)2.69180148
135cell adhesion mediated by integrin (GO:0033627)2.67415004
136barbed-end actin filament capping (GO:0051016)2.67029586
137negative regulation of fatty acid biosynthetic process (GO:0045717)2.65939453
138positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65577482
139negative regulation of lipid transport (GO:0032369)2.65555652
140activation of MAPKKK activity (GO:0000185)2.62600584
141convergent extension (GO:0060026)2.61360364
142hemidesmosome assembly (GO:0031581)2.60969664
143regulation of extracellular matrix disassembly (GO:0010715)2.58513304
144tricarboxylic acid metabolic process (GO:0072350)2.57717124
145response to follicle-stimulating hormone (GO:0032354)2.50690926
146axon extension involved in axon guidance (GO:0048846)2.48474871
147neuron projection extension involved in neuron projection guidance (GO:1902284)2.48474871
148endodermal cell differentiation (GO:0035987)2.44915577
149epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44852084
150negative regulation of cell size (GO:0045792)2.43775353
151activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.43518737
152biotin metabolic process (GO:0006768)2.42734280
153cellular response to prostaglandin stimulus (GO:0071379)2.41523416
154skin morphogenesis (GO:0043589)2.41216391
155positive regulation of extracellular matrix organization (GO:1903055)2.40410167
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.38819750
157axon extension (GO:0048675)2.38777017
158regulation of extracellular matrix organization (GO:1903053)2.36970833
159serine transport (GO:0032329)2.36304958
160cell migration in hindbrain (GO:0021535)2.36178328
161mannose metabolic process (GO:0006013)2.35924513
162stress fiber assembly (GO:0043149)2.31259769
163positive regulation of nuclease activity (GO:0032075)2.29851794
164insulin-like growth factor receptor signaling pathway (GO:0048009)2.29365905
165vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27395302
166skeletal muscle organ development (GO:0060538)2.26215690
167cochlea morphogenesis (GO:0090103)2.23645863
168gap junction assembly (GO:0016264)2.22437863
169Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.21374091
170apoptotic cell clearance (GO:0043277)2.21041640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.71337144
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.57080884
3LXR_22158963_ChIP-Seq_LIVER_Mouse4.02925574
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.72307574
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.61112396
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.56053835
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95323211
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93311126
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83029868
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60835975
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56282067
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.54429240
13* LXR_22292898_ChIP-Seq_THP-1_Human2.53431320
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36035589
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.34957612
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34721594
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.28561932
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24957815
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22908984
20GBX2_23144817_ChIP-Seq_PC3_Human2.19543285
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.18923266
22KDM2B_26808549_Chip-Seq_K562_Human2.15363764
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13558302
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12585093
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.10855310
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10809607
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09484010
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.08466793
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04696175
30* RACK7_27058665_Chip-Seq_MCF-7_Human2.03133145
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98528621
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92148927
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91461582
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79368494
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74300791
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.73194103
37HTT_18923047_ChIP-ChIP_STHdh_Human1.72503838
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62124348
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.61100696
40KDM2B_26808549_Chip-Seq_DND41_Human1.59499151
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59198690
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58131664
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58116482
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57390629
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56837136
46* CLOCK_20551151_ChIP-Seq_293T_Human1.56449410
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54811868
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53622389
49VDR_21846776_ChIP-Seq_THP-1_Human1.52921573
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50388799
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49375409
52MYC_22102868_ChIP-Seq_BL_Human1.48512660
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.45768233
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45617614
55AR_21572438_ChIP-Seq_LNCaP_Human1.44836747
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42052064
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41458378
58ZNF263_19887448_ChIP-Seq_K562_Human1.40782526
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.40486945
60TCF7_22412390_ChIP-Seq_EML_Mouse1.40387600
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39817153
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39623012
63* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39118274
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38922605
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36998399
66* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36764145
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36205801
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35498219
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35498219
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34227933
71TP53_22127205_ChIP-Seq_IMR90_Human1.33558730
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32076409
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31683922
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31519571
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.31465543
76SMC4_20622854_ChIP-Seq_HELA_Human1.29973372
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29405634
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29034475
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.27405809
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27257251
81CREB1_26743006_Chip-Seq_LNCaP_Human1.26051103
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.24489664
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23121550
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22816964
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21731965
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.20920558
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.20463350
88TP53_16413492_ChIP-PET_HCT116_Human1.17802749
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17415583
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17306316
91* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16823125
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16449612
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16234441
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.16093933
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15331633
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.14111335
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.13834998
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11846461
99P68_20966046_ChIP-Seq_HELA_Human1.11816174
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.11176622
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10686270
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09879667
103ATF3_27146783_Chip-Seq_COLON_Human1.08897022
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08619494
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08155869
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07025511
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.06842941
108CTCF_27219007_Chip-Seq_Bcells_Human1.06675825
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.06672484
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06371641
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06248996
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04586334
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04354148
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04038943
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03388356
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01779484
117ER_23166858_ChIP-Seq_MCF-7_Human1.01693839
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.99635330
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99175325
120* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98564843
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97555245
122EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96638515
123RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96638515
124POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96378758
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.96096478
126DROSHA_22980978_ChIP-Seq_HELA_Human0.95434116
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94803656
128EED_16625203_ChIP-ChIP_MESCs_Mouse0.93531382
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93402040
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93179161
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93093548
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92525011
133STAT3_23295773_ChIP-Seq_U87_Human0.92408638
134HNF4A_19822575_ChIP-Seq_HepG2_Human0.92304226
135TAF15_26573619_Chip-Seq_HEK293_Human0.92006233
136GATA1_19941826_ChIP-Seq_K562_Human0.90934736
137EOMES_21245162_ChIP-Seq_HESCs_Human0.90854277
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.90615802
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90478150
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89735471
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89397340
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87509246
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87314551
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.87091317
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86941396
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86489329
147GATA4_25053715_ChIP-Seq_YYC3_Human0.86079261
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85710718
149SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85689647
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84920974
151SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84808147
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84085583
153RXR_22108803_ChIP-Seq_LS180_Human0.83719194
154* FOXA1_25552417_ChIP-Seq_VCAP_Human0.82678874
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81876140
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.81517981
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.81335013
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80918354
159KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80409458
160KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80409458
161KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80409458
162SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80384608
163EZH2_27304074_Chip-Seq_ESCs_Mouse0.80374106
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80198903
165SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79404246
166CBP_21632823_ChIP-Seq_H3396_Human0.79387096
167PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79269271
168RING1B_27294783_Chip-Seq_NPCs_Mouse0.78957765
169RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77854718
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77498203
171SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77389919
172TP53_18474530_ChIP-ChIP_U2OS_Human0.77034611
173EZH2_27294783_Chip-Seq_ESCs_Mouse0.76846332
174MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76810638
175EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75217517
176SOX2_20726797_ChIP-Seq_SW620_Human0.74258615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.90998239
2MP0005083_abnormal_biliary_tract4.80448366
3MP0005085_abnormal_gallbladder_physiolo4.08763413
4MP0005360_urolithiasis4.07488442
5MP0003806_abnormal_nucleotide_metabolis3.67781791
6MP0005365_abnormal_bile_salt3.55762501
7MP0009840_abnormal_foam_cell3.32945552
8MP0000920_abnormal_myelination3.09048936
9MP0004272_abnormal_basement_membrane2.70065774
10MP0008875_abnormal_xenobiotic_pharmacok2.49663235
11MP0003252_abnormal_bile_duct2.46112276
12MP0003195_calcinosis2.42969507
13MP0003329_amyloid_beta_deposits2.30880610
14MP0002089_abnormal_postnatal_growth/wei2.26773422
15MP0003690_abnormal_glial_cell2.25261858
16MP0005451_abnormal_body_composition2.23696353
17MP0003122_maternal_imprinting2.19380971
18MP0003566_abnormal_cell_adhesion2.16861095
19MP0005409_darkened_coat_color2.14331714
20MP0000566_synostosis2.14195352
21MP0005076_abnormal_cell_differentiation2.13139190
22MP0010329_abnormal_lipoprotein_level2.05342816
23MP0003123_paternal_imprinting1.95510522
24MP0003172_abnormal_lysosome_physiology1.90143335
25MP0004885_abnormal_endolymph1.84201130
26MP0000778_abnormal_nervous_system1.82823803
27MP0002118_abnormal_lipid_homeostasis1.81190392
28MP0000647_abnormal_sebaceous_gland1.74138996
29MP0010678_abnormal_skin_adnexa1.74021983
30MP0003868_abnormal_feces_composition1.72980904
31MP0003632_abnormal_nervous_system1.72152861
32MP0005408_hypopigmentation1.64260375
33MP0003011_delayed_dark_adaptation1.62934497
34MP0001915_intracranial_hemorrhage1.58899545
35MP0000462_abnormal_digestive_system1.58165391
36MP0004233_abnormal_muscle_weight1.58024559
37MP0002877_abnormal_melanocyte_morpholog1.56050545
38MP0003634_abnormal_glial_cell1.55091443
39MP0003942_abnormal_urinary_system1.54791405
40MP0003950_abnormal_plasma_membrane1.54446106
41MP0010368_abnormal_lymphatic_system1.53436954
42MP0000604_amyloidosis1.52144132
43MP0001529_abnormal_vocalization1.51058256
44MP0003300_gastrointestinal_ulcer1.51029942
45MP0001666_abnormal_nutrient_absorption1.49898348
46MP0003091_abnormal_cell_migration1.49548258
47MP0009384_cardiac_valve_regurgitation1.47457324
48MP0008438_abnormal_cutaneous_collagen1.42283234
49MP0000383_abnormal_hair_follicle1.38506683
50MP0004381_abnormal_hair_follicle1.38067166
51MP0005332_abnormal_amino_acid1.37890506
52MP0001661_extended_life_span1.35461847
53MP0000372_irregular_coat_pigmentation1.33925399
54MP0003941_abnormal_skin_development1.33001900
55MP0000537_abnormal_urethra_morphology1.30705967
56MP0004742_abnormal_vestibular_system1.29891863
57MP0000579_abnormal_nail_morphology1.29133470
58MP0004134_abnormal_chest_morphology1.27163407
59MP0003937_abnormal_limbs/digits/tail_de1.27022250
60MP0008260_abnormal_autophagy1.26549534
61MP0005666_abnormal_adipose_tissue1.25173069
62MP0002796_impaired_skin_barrier1.25065930
63MP0004142_abnormal_muscle_tone1.24139225
64MP0001958_emphysema1.24015563
65MP0002254_reproductive_system_inflammat1.24007030
66MP0002938_white_spotting1.22466663
67MP0000751_myopathy1.21836402
68MP0000003_abnormal_adipose_tissue1.21149359
69MP0003136_yellow_coat_color1.18485797
70MP0010030_abnormal_orbit_morphology1.17585371
71MP0005375_adipose_tissue_phenotype1.16132338
72MP0000534_abnormal_ureter_morphology1.13467699
73MP0005171_absent_coat_pigmentation1.11428708
74MP0003115_abnormal_respiratory_system1.10151992
75MP0004185_abnormal_adipocyte_glucose1.09136154
76MP0003303_peritoneal_inflammation1.08649876
77MP0010234_abnormal_vibrissa_follicle1.08503842
78MP0005023_abnormal_wound_healing1.08131486
79MP0003718_maternal_effect1.07830535
80MP0001299_abnormal_eye_distance/1.07064102
81MP0004859_abnormal_synaptic_plasticity1.06574623
82MP0002896_abnormal_bone_mineralization1.05862838
83MP0000609_abnormal_liver_physiology1.04944305
84MP0004270_analgesia1.04869666
85MP0000678_abnormal_parathyroid_gland0.99745239
86MP0005275_abnormal_skin_tensile0.98933556
87MP0002092_abnormal_eye_morphology0.98525099
88MP0002249_abnormal_larynx_morphology0.97730675
89MP0001177_atelectasis0.95674611
90MP0002090_abnormal_vision0.94725507
91MP0002697_abnormal_eye_size0.93969126
92MP0003656_abnormal_erythrocyte_physiolo0.93283374
93MP0003890_abnormal_embryonic-extraembry0.93001629
94MP0003279_aneurysm0.92287655
95MP0000767_abnormal_smooth_muscle0.90569974
96MP0001348_abnormal_lacrimal_gland0.89788373
97MP0000467_abnormal_esophagus_morphology0.89562034
98MP0005220_abnormal_exocrine_pancreas0.87919991
99MP0000955_abnormal_spinal_cord0.85265297
100MP0001324_abnormal_eye_pigmentation0.84649615
101MP0005584_abnormal_enzyme/coenzyme_acti0.84348822
102MP0005508_abnormal_skeleton_morphology0.84311716
103MP0003191_abnormal_cellular_cholesterol0.84172477
104MP0004858_abnormal_nervous_system0.83334119
105MP0005195_abnormal_posterior_eye0.82424185
106MP0003631_nervous_system_phenotype0.82374307
107MP0000747_muscle_weakness0.82338821
108MP0003705_abnormal_hypodermis_morpholog0.82247574
109MP0009697_abnormal_copulation0.82165108
110MP0005257_abnormal_intraocular_pressure0.81813522
111MP0006054_spinal_hemorrhage0.80680613
112MP0000428_abnormal_craniofacial_morphol0.80389345
113MP0002971_abnormal_brown_adipose0.80102630
114MP0002229_neurodegeneration0.79966360
115MP0002060_abnormal_skin_morphology0.78841945
116MP0001293_anophthalmia0.78487397
117MP0009672_abnormal_birth_weight0.78338047
118MP0005395_other_phenotype0.77718941
119MP0004510_myositis0.77482963
120MP0009053_abnormal_anal_canal0.75984394
121MP0000733_abnormal_muscle_development0.75804952
122MP0005248_abnormal_Harderian_gland0.75449068
123MP0001486_abnormal_startle_reflex0.75221908
124MP0005423_abnormal_somatic_nervous0.74498880
125MP0002233_abnormal_nose_morphology0.74076830
126MP0005058_abnormal_lysosome_morphology0.73467454
127MP0001905_abnormal_dopamine_level0.73152587
128MP0001485_abnormal_pinna_reflex0.72761496
129MP0005623_abnormal_meninges_morphology0.71823369
130MP0002295_abnormal_pulmonary_circulatio0.71245510
131MP0010630_abnormal_cardiac_muscle0.71243856
132MP0005551_abnormal_eye_electrophysiolog0.71144645
133MP0000639_abnormal_adrenal_gland0.71096174
134MP0004087_abnormal_muscle_fiber0.69884834
135MP0001243_abnormal_dermal_layer0.69293019
136MP0002111_abnormal_tail_morphology0.69194777
137MP0001340_abnormal_eyelid_morphology0.69049760
138MP0005197_abnormal_uvea_morphology0.68929529
139MP0001730_embryonic_growth_arrest0.68418426
140MP0005391_vision/eye_phenotype0.68382554
141MP0000427_abnormal_hair_cycle0.68168625
142MP0003453_abnormal_keratinocyte_physiol0.66516161
143MP0000759_abnormal_skeletal_muscle0.64993980
144MP0002116_abnormal_craniofacial_bone0.64205579
145MP0000377_abnormal_hair_follicle0.63595048
146MP0003879_abnormal_hair_cell0.63228021
147MP0009780_abnormal_chondrocyte_physiolo0.62712753
148MP0005501_abnormal_skin_physiology0.62430954
149MP0004019_abnormal_vitamin_homeostasis0.62225297
150MP0003948_abnormal_gas_homeostasis0.61897423
151MP0000858_altered_metastatic_potential0.61145056
152MP0002098_abnormal_vibrissa_morphology0.61048315
153MP0003861_abnormal_nervous_system0.60928978
154MP0009278_abnormal_bone_marrow0.60894720
155MP0002882_abnormal_neuron_morphology0.60784354
156MP0003315_abnormal_perineum_morphology0.60121843
157MP0002909_abnormal_adrenal_gland0.59809202
158MP0000762_abnormal_tongue_morphology0.59763341
159MP0009765_abnormal_xenobiotic_induced0.58338902
160MP0003385_abnormal_body_wall0.57701277
161MP0001849_ear_inflammation0.57252419

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.45981597
2Parakeratosis (HP:0001036)5.16376562
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.90120967
4Xanthomatosis (HP:0000991)4.70438105
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.70243634
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.70243634
7Deep venous thrombosis (HP:0002625)4.67545888
8Epidermoid cyst (HP:0200040)4.62171583
9Abnormality of the corticospinal tract (HP:0002492)4.50194158
10Neurofibrillary tangles (HP:0002185)4.49164257
11Hypoplastic pelvis (HP:0008839)4.10783755
12Termporal pattern (HP:0011008)4.05824358
13Insidious onset (HP:0003587)4.05824358
14Protrusio acetabuli (HP:0003179)4.03825123
15Abnormality of glycolysis (HP:0004366)3.82365254
16Increased serum pyruvate (HP:0003542)3.82365254
17Cerebral inclusion bodies (HP:0100314)3.79805634
18Hypobetalipoproteinemia (HP:0003563)3.64685319
19Hyperlipoproteinemia (HP:0010980)3.58077961
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42796016
21Prolonged partial thromboplastin time (HP:0003645)3.32501669
22Hyperacusis (HP:0010780)3.30036831
23Peripheral hypomyelination (HP:0007182)3.24892838
24Acanthocytosis (HP:0001927)3.01906745
25Coronal craniosynostosis (HP:0004440)2.75823637
26Congenital ichthyosiform erythroderma (HP:0007431)2.74656815
27Abnormality of methionine metabolism (HP:0010901)2.74056085
28Shallow orbits (HP:0000586)2.73903797
29Myelomeningocele (HP:0002475)2.73127601
30Morphological abnormality of the pyramidal tract (HP:0002062)2.70040457
31Achilles tendon contracture (HP:0001771)2.68691595
32Partial agenesis of the corpus callosum (HP:0001338)2.67975746
33Abnormality of the Achilles tendon (HP:0005109)2.67760586
34Ulnar bowing (HP:0003031)2.67637605
35Abnormality of glycine metabolism (HP:0010895)2.67014589
36Abnormality of serine family amino acid metabolism (HP:0010894)2.67014589
37Onion bulb formation (HP:0003383)2.66977820
38Sensory axonal neuropathy (HP:0003390)2.65961539
39Upper limb amyotrophy (HP:0009129)2.65187566
40Distal upper limb amyotrophy (HP:0007149)2.65187566
41Cerebral aneurysm (HP:0004944)2.63321415
42Vertebral compression fractures (HP:0002953)2.62566930
43Turricephaly (HP:0000262)2.60537119
44Spastic gait (HP:0002064)2.59902250
45Cervical subluxation (HP:0003308)2.59627801
46Hyperglycinemia (HP:0002154)2.59140472
47Relative macrocephaly (HP:0004482)2.52514649
48Peripheral demyelination (HP:0011096)2.50478127
49Insomnia (HP:0100785)2.49630245
50Hypolipoproteinemia (HP:0010981)2.48551317
51Segmental peripheral demyelination/remyelination (HP:0003481)2.45348635
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.45145386
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.44888195
54Nuclear cataract (HP:0100018)2.42378157
55Asymmetry of the thorax (HP:0001555)2.41584395
56Supranuclear gaze palsy (HP:0000605)2.37597871
57Hand muscle atrophy (HP:0009130)2.36706463
58Hypophosphatemic rickets (HP:0004912)2.36682172
59Hammertoe (HP:0001765)2.35961901
60Ankle contracture (HP:0006466)2.32856723
61Hemorrhage of the eye (HP:0011885)2.31971095
62Fat malabsorption (HP:0002630)2.30906388
63Thin bony cortex (HP:0002753)2.29151367
64Skin nodule (HP:0200036)2.27934514
65Atrophic scars (HP:0001075)2.27482299
66Neonatal short-limb short stature (HP:0008921)2.27307304
67Bladder diverticulum (HP:0000015)2.26914297
68Large earlobe (HP:0009748)2.25689213
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25395411
70Advanced eruption of teeth (HP:0006288)2.25283010
71Pseudobulbar signs (HP:0002200)2.24565217
72Intention tremor (HP:0002080)2.23281800
73Renal duplication (HP:0000075)2.18284127
74Abnormality of the common coagulation pathway (HP:0010990)2.17342603
75Mitral regurgitation (HP:0001653)2.17336326
76Disproportionate tall stature (HP:0001519)2.13297090
77Abnormality of carpal bone ossification (HP:0006257)2.12326196
78Flat acetabular roof (HP:0003180)2.11906001
79Biconcave vertebral bodies (HP:0004586)2.11144739
80Akinesia (HP:0002304)2.10675283
81Bronchomalacia (HP:0002780)2.09736466
82Anomalous pulmonary venous return (HP:0010772)2.09160447
83Spastic paraplegia (HP:0001258)2.05344322
84Adrenal hypoplasia (HP:0000835)2.00328846
85Long palpebral fissure (HP:0000637)1.98902656
86Renovascular hypertension (HP:0100817)1.98127028
87Abnormal ossification of hand bones (HP:0005921)1.97441126
88Septate vagina (HP:0001153)1.97076156
89Arnold-Chiari malformation (HP:0002308)1.96471170
90Hypercholesterolemia (HP:0003124)1.96393638
91Stridor (HP:0010307)1.95112207
92Spinal rigidity (HP:0003306)1.94496267
93Overlapping toe (HP:0001845)1.94408342
94Abnormality of complement system (HP:0005339)1.93590510
95Natal tooth (HP:0000695)1.93104472
96Spastic paraparesis (HP:0002313)1.92718815
97Abnormality of dentin (HP:0010299)1.92604396
98Wormian bones (HP:0002645)1.92416461
99Decreased motor nerve conduction velocity (HP:0003431)1.91135738
100Broad metatarsal (HP:0001783)1.91075378
101Heterotopia (HP:0002282)1.91021947
102Hypoalphalipoproteinemia (HP:0003233)1.90812387
103Short nail (HP:0001799)1.90742690
104Complement deficiency (HP:0004431)1.90505446
105Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90451325
106Infantile muscular hypotonia (HP:0008947)1.90269049
107Blue sclerae (HP:0000592)1.89771542
108Peritonitis (HP:0002586)1.89433958
109Bifid scrotum (HP:0000048)1.89335565
110Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88154889
111Irritability (HP:0000737)1.87874273
112Premature skin wrinkling (HP:0100678)1.87029064
113Broad face (HP:0000283)1.84569498
114Generalized hypotonia (HP:0001290)1.83501086
115Dysostosis multiplex (HP:0000943)1.83263632
116Clonus (HP:0002169)1.82985150
117Urinary glycosaminoglycan excretion (HP:0003541)1.82421033
118Mucopolysacchariduria (HP:0008155)1.82421033
119Epiphyseal stippling (HP:0010655)1.82388902
120Hyperammonemia (HP:0001987)1.81880687
121Abnormal gallbladder morphology (HP:0012437)1.81476422
122Vascular tortuosity (HP:0004948)1.80746419
123Back pain (HP:0003418)1.79769150
124Aplasia involving bones of the extremities (HP:0009825)1.79016636
125Aplasia involving bones of the upper limbs (HP:0009823)1.79016636
126Aplasia of the phalanges of the hand (HP:0009802)1.79016636
127Myocardial infarction (HP:0001658)1.78928669
128Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78831724
129Small epiphyses (HP:0010585)1.78160777
130Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77717106
131Steatorrhea (HP:0002570)1.77185879
132Mitral stenosis (HP:0001718)1.76805633
133Vertebral clefting (HP:0008428)1.76380099
134Precocious puberty (HP:0000826)1.76207686
135Abnormal gallbladder physiology (HP:0012438)1.75655801
136Cholecystitis (HP:0001082)1.75655801
137Spastic tetraparesis (HP:0001285)1.74923022
138Microglossia (HP:0000171)1.74877694
139Mildly elevated creatine phosphokinase (HP:0008180)1.74533430
140Reticulocytosis (HP:0001923)1.74419982
141Septo-optic dysplasia (HP:0100842)1.73553103
142Postural tremor (HP:0002174)1.73405986
143Paraplegia (HP:0010550)1.73310058
144Ketosis (HP:0001946)1.72804431
145Rickets (HP:0002748)1.71573740
146Impaired pain sensation (HP:0007328)1.71542398
147Abnormality of pain sensation (HP:0010832)1.71542398
148Overriding aorta (HP:0002623)1.71213408
149Breech presentation (HP:0001623)1.71009886
150Cupped ear (HP:0000378)1.70065612
151Spastic diplegia (HP:0001264)1.69708872
152Abnormality of the pulmonary veins (HP:0011718)1.69320915
153Premature rupture of membranes (HP:0001788)1.68924547
154Opisthotonus (HP:0002179)1.68873375
155Fragile skin (HP:0001030)1.68802242
156Abnormality of the gallbladder (HP:0005264)1.68649617
157Cupped ribs (HP:0000887)1.67915953
158Axonal loss (HP:0003447)1.67862994
159Arterial tortuosity (HP:0005116)1.67676034
160Joint hemorrhage (HP:0005261)1.67317964
161Abnormality of polysaccharide metabolism (HP:0011012)1.66692483
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66692483
163Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66692483
164Clumsiness (HP:0002312)1.66225127
165Thin ribs (HP:0000883)1.65825835
166Abnormal delivery (HP:0001787)1.65626892
167Absent septum pellucidum (HP:0001331)1.65404304
168Genu recurvatum (HP:0002816)1.65289973
169Patellar dislocation (HP:0002999)1.64960899
170Abnormality of the acetabulum (HP:0003170)1.64537028
171Increased variability in muscle fiber diameter (HP:0003557)1.64473798
172Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64290941
173Elfin facies (HP:0004428)1.63844123
174Increased nuchal translucency (HP:0010880)1.63559457
175Conjugated hyperbilirubinemia (HP:0002908)1.63134634
176Pointed chin (HP:0000307)1.63062764
177Hyperparathyroidism (HP:0000843)1.62813559
178Hypochromic microcytic anemia (HP:0004840)1.62800942
179Aneurysm (HP:0002617)1.62483543
180Neonatal death (HP:0003811)1.62422729
181Hyperextensible skin (HP:0000974)1.62037604
182Distal lower limb amyotrophy (HP:0008944)1.59718873
183Cortical dysplasia (HP:0002539)1.59693469
184Abnormality of the thoracic spine (HP:0100711)1.59512868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.90175093
2TRIB34.63408769
3EPHB14.50806843
4RIPK13.11731957
5MET2.93381298
6IRAK32.86139638
7SIK12.73190963
8BCR2.68724681
9OXSR12.59516945
10MARK12.59391872
11PBK2.40778247
12PKN12.27528453
13PRPF4B2.22536267
14SMG12.16579562
15ICK2.07371368
16FGFR22.04703876
17CDK122.01913544
18TESK21.99260030
19NTRK11.94130203
20ERBB41.93523401
21PKN21.90451565
22CSNK1G31.82465522
23LATS11.80326381
24FGR1.80202317
25MAPKAPK51.79961245
26TNIK1.77278927
27CSNK1A1L1.76643549
28DYRK21.75737458
29ERN11.72658006
30UHMK11.70234350
31CAMK1G1.66496229
32WNK41.61425719
33PAK61.50439686
34TTN1.49097000
35CSNK1G11.46900943
36CAMK1D1.44706038
37TYRO31.43670682
38CSNK1G21.42267908
39EPHB21.40873317
40LIMK11.39170608
41ARAF1.36762208
42EPHA21.32495708
43PAK31.32153773
44PIM21.27269713
45CDC42BPA1.20863095
46RPS6KA21.20560618
47TAOK21.19531040
48TESK11.15342963
49MAP3K101.14381563
50BMX1.12655603
51NME21.07822632
52FGFR41.06393434
53PTK21.04792613
54PRKD31.03318357
55PNCK1.02745392
56MST1R1.01726018
57ERBB21.00802544
58FGFR30.99263307
59WNK10.98555206
60MOS0.97376500
61PDGFRB0.96361009
62GSK3A0.93931685
63PAK40.92908386
64DDR20.92125334
65SGK4940.90948332
66SGK2230.90948332
67TAOK10.88990117
68SIK20.88201312
69CSNK1D0.87659625
70MARK20.85780858
71MAP3K20.81266100
72ROCK20.80724562
73BRAF0.78942383
74LMTK20.78687598
75FGFR10.78537186
76MAP3K90.74772118
77PAK20.74581079
78MTOR0.71696281
79PRKD20.71362367
80NEK90.70073950
81NEK60.69316234
82RET0.67709198
83CSF1R0.67619895
84CDK140.66330568
85IRAK20.66145829
86PDGFRA0.65331555
87MAP3K60.63704445
88CSNK1E0.63658660
89ABL20.62419443
90ALK0.61796237
91CLK10.61096517
92CDK150.59554855
93STK30.58429897
94MKNK10.57237011
95MAPK130.56674502
96NTRK20.56572519
97MAPK110.56474515
98PRKCQ0.56134564
99EPHA30.56099810
100KSR20.56043731
101INSRR0.53915585
102MAP3K110.53848735
103CDK180.53507732
104RPS6KC10.52980432
105RPS6KL10.52980432
106BRD40.51578814
107FYN0.51169080
108CAMK2B0.50904130
109FLT30.50818054
110CDK11A0.50558014
111INSR0.49907104
112MAP2K30.48991988
113PTK60.48874495
114SGK30.48557912
115CDK60.47915975
116CDK50.44331463
117CDK190.43930185
118BMPR1B0.43903385
119MAP3K10.43576178
120AKT20.43381548
121MAP3K80.42958635
122ROCK10.42736420
123KSR10.42074232
124PRKAA10.40848374
125PRKCZ0.40838267
126BCKDK0.39132570
127PRKACB0.38052253
128DMPK0.37563390
129SRC0.37495958
130DYRK1B0.37224216
131PRKACG0.36268732
132MAPK100.34617864
133LATS20.34280615
134IGF1R0.33492857
135CAMK2D0.33133689
136CDK70.33071629
137MAP2K20.32939548
138EEF2K0.32840811
139NTRK30.32698122
140CAMK2G0.31085496
141PRKCE0.30968786
142CDK10.30149769
143MAP3K30.29206166
144HIPK20.28855854
145ILK0.28435525
146PRKG10.28368708
147CSNK1A10.28000485
148RPS6KA60.27621188
149MAPK40.27586352
150TBK10.27376467
151PDPK10.27184756
152CAMK2A0.26952115
153PAK10.26580171

Predicted pathways (KEGG)

RankGene SetZ-score
1* Steroid biosynthesis_Homo sapiens_hsa001005.88866153
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.58831125
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.48646983
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.95587608
5Fatty acid elongation_Homo sapiens_hsa000623.50288043
6Butanoate metabolism_Homo sapiens_hsa006502.87683744
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.71162737
8Nitrogen metabolism_Homo sapiens_hsa009102.66808846
9Fatty acid metabolism_Homo sapiens_hsa012122.39432022
10Other glycan degradation_Homo sapiens_hsa005112.25713299
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17176416
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02761881
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95385989
14Tryptophan metabolism_Homo sapiens_hsa003801.84277919
15Histidine metabolism_Homo sapiens_hsa003401.83565877
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81614661
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80888219
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.76500574
19Fatty acid degradation_Homo sapiens_hsa000711.68395099
20Propanoate metabolism_Homo sapiens_hsa006401.61166881
21Fatty acid biosynthesis_Homo sapiens_hsa000611.61150946
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60420699
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.60233690
24Sulfur metabolism_Homo sapiens_hsa009201.59068891
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56241247
26Arginine biosynthesis_Homo sapiens_hsa002201.54908750
27Peroxisome_Homo sapiens_hsa041461.51587465
28Vitamin B6 metabolism_Homo sapiens_hsa007501.50820963
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49156092
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47982891
31Complement and coagulation cascades_Homo sapiens_hsa046101.34007976
32Ether lipid metabolism_Homo sapiens_hsa005651.30824166
33Folate biosynthesis_Homo sapiens_hsa007901.26312689
34PPAR signaling pathway_Homo sapiens_hsa033201.26239773
35Notch signaling pathway_Homo sapiens_hsa043301.25682885
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23828216
37VEGF signaling pathway_Homo sapiens_hsa043701.23095398
38Chemical carcinogenesis_Homo sapiens_hsa052041.21339943
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20847422
40Chronic myeloid leukemia_Homo sapiens_hsa052201.20405908
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19976351
42Retinol metabolism_Homo sapiens_hsa008301.19378708
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18343455
44Endometrial cancer_Homo sapiens_hsa052131.17881540
45Tyrosine metabolism_Homo sapiens_hsa003501.17624447
46Pyruvate metabolism_Homo sapiens_hsa006201.16699734
47Insulin signaling pathway_Homo sapiens_hsa049101.15078845
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10588053
49beta-Alanine metabolism_Homo sapiens_hsa004101.08117774
50Focal adhesion_Homo sapiens_hsa045101.07222093
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06626945
52Fructose and mannose metabolism_Homo sapiens_hsa000511.06277008
53Phenylalanine metabolism_Homo sapiens_hsa003601.03777797
54Fat digestion and absorption_Homo sapiens_hsa049751.03280269
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02620797
56Galactose metabolism_Homo sapiens_hsa000521.01981441
57Bile secretion_Homo sapiens_hsa049761.00605097
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00236157
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99290242
60Arginine and proline metabolism_Homo sapiens_hsa003300.98287007
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98269676
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.96445003
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96070349
64Proteoglycans in cancer_Homo sapiens_hsa052050.89420802
65Lysosome_Homo sapiens_hsa041420.89284931
66Amoebiasis_Homo sapiens_hsa051460.89208754
67Adherens junction_Homo sapiens_hsa045200.88252190
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87833176
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87529284
70Selenocompound metabolism_Homo sapiens_hsa004500.85978257
71Glioma_Homo sapiens_hsa052140.82193725
72Linoleic acid metabolism_Homo sapiens_hsa005910.81028820
73Acute myeloid leukemia_Homo sapiens_hsa052210.81003653
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80540851
75Vibrio cholerae infection_Homo sapiens_hsa051100.80249592
76Thyroid cancer_Homo sapiens_hsa052160.78807654
77Prolactin signaling pathway_Homo sapiens_hsa049170.78215895
78Sulfur relay system_Homo sapiens_hsa041220.77241272
79MicroRNAs in cancer_Homo sapiens_hsa052060.74597638
80Non-small cell lung cancer_Homo sapiens_hsa052230.73344792
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73244132
82Biosynthesis of amino acids_Homo sapiens_hsa012300.73100694
83mTOR signaling pathway_Homo sapiens_hsa041500.72874247
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72538728
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.70895899
86ABC transporters_Homo sapiens_hsa020100.70003751
87Axon guidance_Homo sapiens_hsa043600.69854662
88Lysine degradation_Homo sapiens_hsa003100.69827721
89Staphylococcus aureus infection_Homo sapiens_hsa051500.68924266
90Estrogen signaling pathway_Homo sapiens_hsa049150.68105464
91Small cell lung cancer_Homo sapiens_hsa052220.67060411
92Insulin resistance_Homo sapiens_hsa049310.66139868
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.66102423
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63811704
95Glutathione metabolism_Homo sapiens_hsa004800.61767563
96Pancreatic cancer_Homo sapiens_hsa052120.58962490
97Vitamin digestion and absorption_Homo sapiens_hsa049770.58837856
98GnRH signaling pathway_Homo sapiens_hsa049120.58753068
99Carbon metabolism_Homo sapiens_hsa012000.57847095
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.57710520
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56502984
102Ovarian steroidogenesis_Homo sapiens_hsa049130.55754727
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55576859
104Gap junction_Homo sapiens_hsa045400.55277938
105Salmonella infection_Homo sapiens_hsa051320.52179364
106Type II diabetes mellitus_Homo sapiens_hsa049300.51996170
107Glucagon signaling pathway_Homo sapiens_hsa049220.51134595
108Choline metabolism in cancer_Homo sapiens_hsa052310.50796894
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.49469375
110Sphingolipid metabolism_Homo sapiens_hsa006000.48890415
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.48817893
112One carbon pool by folate_Homo sapiens_hsa006700.48430361
113Dilated cardiomyopathy_Homo sapiens_hsa054140.47571436
114HIF-1 signaling pathway_Homo sapiens_hsa040660.45016109
115Glycerolipid metabolism_Homo sapiens_hsa005610.44719767
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44585017
117TNF signaling pathway_Homo sapiens_hsa046680.43722578
118N-Glycan biosynthesis_Homo sapiens_hsa005100.42995177
119Colorectal cancer_Homo sapiens_hsa052100.41393705
120Caffeine metabolism_Homo sapiens_hsa002320.40137329
121* Metabolic pathways_Homo sapiens_hsa011000.38672744
122Pentose phosphate pathway_Homo sapiens_hsa000300.33663619
123Renal cell carcinoma_Homo sapiens_hsa052110.32756909
124Starch and sucrose metabolism_Homo sapiens_hsa005000.30183551
125Prion diseases_Homo sapiens_hsa050200.30019307
126Tight junction_Homo sapiens_hsa045300.24726405
127Hedgehog signaling pathway_Homo sapiens_hsa043400.22740075
128ECM-receptor interaction_Homo sapiens_hsa045120.21613176
129Basal cell carcinoma_Homo sapiens_hsa052170.21530165
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21515420
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18410275
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12983543
133AMPK signaling pathway_Homo sapiens_hsa041520.12796625
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.08023642
135Hippo signaling pathway_Homo sapiens_hsa043900.06632121
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.05581884
137ErbB signaling pathway_Homo sapiens_hsa040120.01384419
138Serotonergic synapse_Homo sapiens_hsa047260.00953400
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.00287535
140Hepatitis C_Homo sapiens_hsa05160-0.0745336
141Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0714408
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0665842
143Prostate cancer_Homo sapiens_hsa05215-0.0642913
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0595266
145Ras signaling pathway_Homo sapiens_hsa04014-0.0442429
146PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0400158
147Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0382209
148Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0375203
149Long-term depression_Homo sapiens_hsa04730-0.0152465
150Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0087095
151Bladder cancer_Homo sapiens_hsa05219-0.0050861

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