LST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.62210167
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.07127588
3negative regulation of cell killing (GO:0031342)6.07127588
4neutrophil activation involved in immune response (GO:0002283)5.92262892
5ribosomal small subunit assembly (GO:0000028)5.59188707
6response to peptidoglycan (GO:0032494)4.70051574
7response to interferon-beta (GO:0035456)4.62077082
8detection of bacterium (GO:0016045)4.61317608
9negative regulation of interleukin-12 production (GO:0032695)4.56899401
10mature B cell differentiation involved in immune response (GO:0002313)4.54130225
11viral transcription (GO:0019083)4.41566150
12immunoglobulin mediated immune response (GO:0016064)4.27868960
13macrophage activation involved in immune response (GO:0002281)4.24287815
14response to interferon-alpha (GO:0035455)4.21629595
15respiratory burst (GO:0045730)4.18672771
16regulation of gamma-delta T cell activation (GO:0046643)4.17819084
17translational termination (GO:0006415)4.17153131
18regulation of B cell receptor signaling pathway (GO:0050855)4.14556275
19eosinophil chemotaxis (GO:0048245)4.14043632
20detection of external biotic stimulus (GO:0098581)4.13369023
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07120752
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.07120752
23modulation by symbiont of host immune response (GO:0052553)4.07120752
24positive regulation by symbiont of host defense response (GO:0052509)4.07120752
25modulation by symbiont of host defense response (GO:0052031)4.07120752
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07120752
27platelet dense granule organization (GO:0060155)4.04932991
28mature B cell differentiation (GO:0002335)4.01181212
29granulocyte activation (GO:0036230)4.00364571
30myeloid cell activation involved in immune response (GO:0002275)4.00326447
31detection of molecule of bacterial origin (GO:0032490)3.96209190
32negative regulation of lymphocyte mediated immunity (GO:0002707)3.93138069
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.92460253
34antigen processing and presentation via MHC class Ib (GO:0002475)3.90962723
35eosinophil migration (GO:0072677)3.88796666
36regulation of interferon-beta biosynthetic process (GO:0045357)3.86258523
37neutrophil activation (GO:0042119)3.85040775
38endosome to pigment granule transport (GO:0043485)3.77592761
39endosome to melanosome transport (GO:0035646)3.77592761
40production of molecular mediator involved in inflammatory response (GO:0002532)3.74180362
41definitive hemopoiesis (GO:0060216)3.73527864
42detection of biotic stimulus (GO:0009595)3.70723515
43negative regulation of T cell mediated immunity (GO:0002710)3.69654214
44regulation of gamma-delta T cell differentiation (GO:0045586)3.67434303
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.66860607
46defense response to protozoan (GO:0042832)3.64262692
47mast cell activation (GO:0045576)3.63820642
48type I interferon signaling pathway (GO:0060337)3.63516578
49cellular response to type I interferon (GO:0071357)3.63516578
50response to type I interferon (GO:0034340)3.60204981
51leukocyte migration involved in inflammatory response (GO:0002523)3.59714017
52positive regulation of interferon-alpha production (GO:0032727)3.58805019
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.57534922
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55966307
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.55966307
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54212964
57negative regulation of leukocyte mediated immunity (GO:0002704)3.53257954
58response to protozoan (GO:0001562)3.51048519
59cotranslational protein targeting to membrane (GO:0006613)3.46726215
60ribosomal small subunit biogenesis (GO:0042274)3.46297519
61regulation of mast cell degranulation (GO:0043304)3.45713134
62protein targeting to ER (GO:0045047)3.45607758
63regulation of leukocyte degranulation (GO:0043300)3.44536100
64positive regulation of B cell differentiation (GO:0045579)3.44455802
65positive regulation of gamma-delta T cell activation (GO:0046645)3.44312854
66regulation of MHC class II biosynthetic process (GO:0045346)3.42714434
67T-helper 1 type immune response (GO:0042088)3.41180235
68response to interleukin-15 (GO:0070672)3.40707038
69microglial cell activation (GO:0001774)3.40703725
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40545930
71translational elongation (GO:0006414)3.39592937
72regulation of interferon-alpha production (GO:0032647)3.39115564
73positive regulation of macrophage differentiation (GO:0045651)3.38585584
74neutrophil mediated immunity (GO:0002446)3.38522126
75antigen processing and presentation of endogenous antigen (GO:0019883)3.37393456
76leukocyte degranulation (GO:0043299)3.36367097
77tolerance induction (GO:0002507)3.35614454
78myeloid dendritic cell activation (GO:0001773)3.33050243
79regulation of mast cell activation (GO:0033003)3.32475494
80regulation of T-helper 1 cell differentiation (GO:0045625)3.31408987
81B cell mediated immunity (GO:0019724)3.30775978
82cellular response to interleukin-15 (GO:0071350)3.30098514
83phagocytosis, engulfment (GO:0006911)3.29691108
84monocyte chemotaxis (GO:0002548)3.29362779
85regulation of mast cell activation involved in immune response (GO:0033006)3.28138197
86protein localization to endoplasmic reticulum (GO:0070972)3.27257828
87establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26608708
88positive regulation of antigen processing and presentation (GO:0002579)3.26447198
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18699604
90negative regulation of viral genome replication (GO:0045071)3.18252280
91interferon-gamma-mediated signaling pathway (GO:0060333)3.17098108
92viral life cycle (GO:0019058)3.17079569
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16221542
94response to host (GO:0075136)3.16221542
95response to host defenses (GO:0052200)3.16221542
96regulation of T cell mediated cytotoxicity (GO:0001914)3.16084752
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.15356594
98regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13798081
99myeloid dendritic cell differentiation (GO:0043011)3.13088009
100regulation of tolerance induction (GO:0002643)3.12828288
101positive regulation of lymphocyte migration (GO:2000403)3.12554920
102positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12150239
103regulation of T cell tolerance induction (GO:0002664)3.11562992
104germinal center formation (GO:0002467)3.10452788
105cellular extravasation (GO:0045123)3.09374970
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09004219
107macrophage activation (GO:0042116)3.08708981
108T cell migration (GO:0072678)3.08545936
109pinocytosis (GO:0006907)3.08346623
110cellular response to interferon-beta (GO:0035458)3.06142137
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05935452
112positive regulation of mast cell activation involved in immune response (GO:0033008)3.04871139
113positive regulation of mast cell degranulation (GO:0043306)3.04871139
114negative regulation of erythrocyte differentiation (GO:0045647)3.04247800
115positive thymic T cell selection (GO:0045059)3.04227002
116myeloid leukocyte activation (GO:0002274)3.03874268
117positive regulation of T cell mediated cytotoxicity (GO:0001916)3.01005585
118negative thymic T cell selection (GO:0045060)2.99985668
119regulation of B cell differentiation (GO:0045577)2.99967625
120nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99671631
121positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98586823
122B cell receptor signaling pathway (GO:0050853)2.96902731
123cellular protein complex disassembly (GO:0043624)2.96769688
124positive regulation of interleukin-17 production (GO:0032740)2.93690415
125negative regulation of interleukin-6 production (GO:0032715)2.93433089
126myeloid leukocyte mediated immunity (GO:0002444)2.92895898
127regulation of regulated secretory pathway (GO:1903305)2.92579561
128negative regulation of cytokine production involved in immune response (GO:0002719)2.92446391
129negative T cell selection (GO:0043383)2.91948955
130positive regulation of cellular amide metabolic process (GO:0034250)2.91867760
131regulation of alpha-beta T cell proliferation (GO:0046640)2.91366553
132positive regulation of mast cell activation (GO:0033005)2.90604242
133maturation of SSU-rRNA (GO:0030490)2.90453705
134megakaryocyte development (GO:0035855)2.89235263
135neutrophil chemotaxis (GO:0030593)2.89187673
136negative regulation of phagocytosis (GO:0050765)2.88869248
137lymphocyte chemotaxis (GO:0048247)2.88361787
138response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87762190
139response to host immune response (GO:0052572)2.87762190
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86922865
141detection of other organism (GO:0098543)2.86547955
142response to muramyl dipeptide (GO:0032495)2.85284452
143leukocyte aggregation (GO:0070486)2.84690339
144regulation of antigen processing and presentation (GO:0002577)2.83200634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.98985632
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.42059411
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.30130971
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.25586940
5SCL_19346495_ChIP-Seq_HPC-7_Human4.15368914
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.10676432
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.72078535
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63987923
9* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.37606663
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.30512599
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.26529995
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.17794566
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11123063
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86121532
15* SPI1_23547873_ChIP-Seq_NB4_Human2.83008313
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80705225
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.70845548
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.58793703
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58452676
20* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.57326760
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53643123
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52913449
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24299649
24* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.23953476
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.22844583
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19904007
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16724987
28* RUNX1_22412390_ChIP-Seq_EML_Mouse2.14362124
29VDR_21846776_ChIP-Seq_THP-1_Human2.10577722
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09747875
31VDR_24763502_ChIP-Seq_THP-1_Human2.05276926
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02332622
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02202548
34MYB_26560356_Chip-Seq_TH2_Human1.83321321
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.79379100
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.79094587
37* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77420684
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75832152
39MAF_26560356_Chip-Seq_TH1_Human1.71594956
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70944031
41SPI1_23127762_ChIP-Seq_K562_Human1.63462834
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62967837
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61065434
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60358010
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59663679
46* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.56859043
47MYB_26560356_Chip-Seq_TH1_Human1.56831323
48RUNX_20019798_ChIP-Seq_JUKART_Human1.55488917
49* PU_27001747_Chip-Seq_BMDM_Mouse1.55117375
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54837439
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54248170
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52084338
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50788230
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47375627
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.44859527
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44052237
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35799234
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35597850
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34831211
60MYC_22102868_ChIP-Seq_BL_Human1.34472324
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34375919
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31681561
63* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31577849
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28253116
65* UTX_26944678_Chip-Seq_JUKART_Human1.27592018
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27154192
67TCF7_22412390_ChIP-Seq_EML_Mouse1.25375493
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24943975
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.24814562
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.24434672
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22838099
72KDM2B_26808549_Chip-Seq_DND41_Human1.19172455
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18273843
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16709132
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.15822986
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14607003
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.14250237
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13689310
79E2F7_22180533_ChIP-Seq_HELA_Human1.09484907
80BCOR_27268052_Chip-Seq_Bcells_Human1.09399642
81GATA3_26560356_Chip-Seq_TH2_Human1.09307914
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05631248
83GATA1_22025678_ChIP-Seq_K562_Human1.05558487
84VDR_24787735_ChIP-Seq_THP-1_Human1.03914406
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02694248
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01756234
87* MAF_26560356_Chip-Seq_TH2_Human1.00834348
88GATA3_27048872_Chip-Seq_THYMUS_Human0.98680041
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98082186
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96328362
91EGR1_19032775_ChIP-ChIP_M12_Human0.95430471
92LXR_22292898_ChIP-Seq_THP-1_Human0.95411787
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95049862
94VDR_23849224_ChIP-Seq_CD4+_Human0.95007247
95* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94910859
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94857982
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.94490081
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.93799536
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92413309
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.91960395
101SPI1_20517297_ChIP-Seq_HL60_Human0.90803801
102MYC_18555785_ChIP-Seq_MESCs_Mouse0.90439850
103SRF_21415370_ChIP-Seq_HL-1_Mouse0.88808521
104P300_27268052_Chip-Seq_Bcells_Human0.87839481
105GATA2_19941826_ChIP-Seq_K562_Human0.87316224
106RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87304275
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85289130
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84897918
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83461421
110GATA1_19941826_ChIP-Seq_K562_Human0.83390900
111SMRT_27268052_Chip-Seq_Bcells_Human0.81916193
112RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81471654
113FOXP3_21729870_ChIP-Seq_TREG_Human0.79718772
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.79045893
115ELK1_19687146_ChIP-ChIP_HELA_Human0.78512367
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77632338
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76023802
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73528946
119BCL6_27268052_Chip-Seq_Bcells_Human0.72706075
120STAT1_20625510_ChIP-Seq_HELA_Human0.71341954
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.71189199
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.71068149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.66890188
2MP0003436_decreased_susceptibility_to3.81798529
3MP0009785_altered_susceptibility_to3.78135889
4MP0002148_abnormal_hypersensitivity_rea3.72836872
5MP0002419_abnormal_innate_immunity3.20053086
6MP0005025_abnormal_response_to3.08910367
7MP0005671_abnormal_response_to3.08374542
8MP0005000_abnormal_immune_tolerance2.96207985
9MP0005464_abnormal_platelet_physiology2.91541382
10MP0003724_increased_susceptibility_to2.90070857
11MP0000685_abnormal_immune_system2.75798215
12MP0002452_abnormal_antigen_presenting2.74621720
13MP0005058_abnormal_lysosome_morphology2.67964738
14MP0001800_abnormal_humoral_immune2.67652035
15MP0002723_abnormal_immune_serum2.64405318
16MP0006082_CNS_inflammation2.57876227
17MP0002420_abnormal_adaptive_immunity2.47992505
18MP0001819_abnormal_immune_cell2.47218804
19MP0003303_peritoneal_inflammation2.42372582
20MP0001790_abnormal_immune_system2.40982247
21MP0005387_immune_system_phenotype2.40982247
22MP0005174_abnormal_tail_pigmentation2.24530876
23MP0002396_abnormal_hematopoietic_system2.10268885
24MP0003191_abnormal_cellular_cholesterol2.05087818
25MP0004510_myositis2.01298704
26MP0001533_abnormal_skeleton_physiology1.97148811
27MP0002405_respiratory_system_inflammati1.96438894
28MP0002398_abnormal_bone_marrow1.96316402
29MP0001853_heart_inflammation1.93301820
30MP0000716_abnormal_immune_system1.90771679
31MP0001845_abnormal_inflammatory_respons1.87191990
32MP0001545_abnormal_hematopoietic_system1.85710763
33MP0005397_hematopoietic_system_phenotyp1.85710763
34MP0000343_altered_response_to1.83394428
35MP0004808_abnormal_hematopoietic_stem1.81792971
36MP0010155_abnormal_intestine_physiology1.78363383
37MP0000689_abnormal_spleen_morphology1.77047811
38MP0009379_abnormal_foot_pigmentation1.72106009
39MP0009333_abnormal_splenocyte_physiolog1.67759992
40MP0002429_abnormal_blood_cell1.66001339
41MP0000465_gastrointestinal_hemorrhage1.64766560
42MP0008469_abnormal_protein_level1.64306710
43MP0009764_decreased_sensitivity_to1.62909213
44MP0002722_abnormal_immune_system1.62098042
45MP0009278_abnormal_bone_marrow1.56983343
46MP0003172_abnormal_lysosome_physiology1.55895287
47MP0009840_abnormal_foam_cell1.45636470
48MP0003075_altered_response_to1.44348226
49MP0005310_abnormal_salivary_gland1.40142467
50MP0003763_abnormal_thymus_physiology1.37578017
51MP0000490_abnormal_crypts_of1.34166092
52MP0003806_abnormal_nucleotide_metabolis1.33669518
53MP0002166_altered_tumor_susceptibility1.33237620
54MP0002095_abnormal_skin_pigmentation1.31543109
55MP0003866_abnormal_defecation1.31288901
56MP0000015_abnormal_ear_pigmentation1.24704371
57MP0002006_tumorigenesis1.20790483
58MP0008260_abnormal_autophagy1.17039717
59MP0001851_eye_inflammation1.15778129
60MP0005075_abnormal_melanosome_morpholog1.14420260
61MP0002998_abnormal_bone_remodeling1.12516727
62MP0003828_pulmonary_edema1.11958545
63MP0002277_abnormal_respiratory_mucosa1.11067190
64MP0001873_stomach_inflammation1.07492181
65MP0003183_abnormal_peptide_metabolism1.02642738
66MP0005166_decreased_susceptibility_to1.01595483
67MP0000858_altered_metastatic_potential1.01256170
68MP0003448_altered_tumor_morphology1.01175933
69MP0004947_skin_inflammation1.00313133
70MP0002138_abnormal_hepatobiliary_system0.99922445
71MP0001986_abnormal_taste_sensitivity0.99110245
72MP0004147_increased_porphyrin_level0.98552288
73MP0004381_abnormal_hair_follicle0.97713068
74MP0000604_amyloidosis0.95381088
75MP0002254_reproductive_system_inflammat0.95172453
76MP0000703_abnormal_thymus_morphology0.94625293
77MP0002933_joint_inflammation0.92595911
78MP0009763_increased_sensitivity_to0.90484453
79MP0005409_darkened_coat_color0.90337208
80MP0003186_abnormal_redox_activity0.88520315
81MP0005390_skeleton_phenotype0.88106803
82MP0003656_abnormal_erythrocyte_physiolo0.87468342
83MP0010368_abnormal_lymphatic_system0.87434275
84MP0005167_abnormal_blood-brain_barrier0.87109971
85MP0005164_abnormal_response_to0.82813789
86MP0005377_hearing/vestibular/ear_phenot0.81797704
87MP0003878_abnormal_ear_physiology0.81797704
88MP0009765_abnormal_xenobiotic_induced0.80789519
89MP0002638_abnormal_pupillary_reflex0.78964570
90MP0005451_abnormal_body_composition0.77833607
91MP0001663_abnormal_digestive_system0.76991896
92MP0000249_abnormal_blood_vessel0.76188247
93MP0006054_spinal_hemorrhage0.70049900
94MP0000569_abnormal_digit_pigmentation0.69447620
95MP0002132_abnormal_respiratory_system0.65183200
96MP0003795_abnormal_bone_structure0.65177653
97MP0005083_abnormal_biliary_tract0.64788591
98MP0004782_abnormal_surfactant_physiolog0.63598230
99MP0006292_abnormal_olfactory_placode0.62679570
100MP0000681_abnormal_thyroid_gland0.60207463
101MP0003638_abnormal_response/metabolism_0.59845247
102MP0002653_abnormal_ependyma_morphology0.59146161
103MP0004130_abnormal_muscle_cell0.59118987
104MP0005319_abnormal_enzyme/_coenzyme0.58549243
105MP0004883_abnormal_blood_vessel0.58111535
106MP0002019_abnormal_tumor_incidence0.57606381
107MP0003195_calcinosis0.56423866
108MP0002693_abnormal_pancreas_physiology0.55435501
109MP0008873_increased_physiological_sensi0.55399225
110MP0003011_delayed_dark_adaptation0.55051295
111MP0001879_abnormal_lymphatic_vessel0.54650928
112MP0003300_gastrointestinal_ulcer0.54266339
113MP0008874_decreased_physiological_sensi0.53970038
114MP0003045_fibrosis0.52977171
115MP0005084_abnormal_gallbladder_morpholo0.52753189
116MP0002136_abnormal_kidney_physiology0.52635562
117MP0008004_abnormal_stomach_pH0.51571296
118MP0005584_abnormal_enzyme/coenzyme_acti0.50166736
119MP0003690_abnormal_glial_cell0.49465962

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.75529097
2Recurrent bacterial skin infections (HP:0005406)6.09324051
3Eczematoid dermatitis (HP:0000976)5.63128193
4Myositis (HP:0100614)4.56495024
5Vacuolated lymphocytes (HP:0001922)4.41823485
6Recurrent gram-negative bacterial infections (HP:0005420)4.40893156
7Elevated erythrocyte sedimentation rate (HP:0003565)4.39841744
8Abnormality of macrophages (HP:0004311)4.28804078
9Thrombocytosis (HP:0001894)4.23198333
10Recurrent skin infections (HP:0001581)4.01423486
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.96951482
12Abnormality of cells of the erythroid lineage (HP:0012130)3.90553581
13Abnormal number of erythroid precursors (HP:0012131)3.74610145
14Obstructive lung disease (HP:0006536)3.70645321
15Chronic obstructive pulmonary disease (HP:0006510)3.70645321
16Increased cerebral lipofuscin (HP:0011813)3.68922400
17Gastrointestinal infarctions (HP:0005244)3.68359596
18Mediastinal lymphadenopathy (HP:0100721)3.67401414
19Reticulocytopenia (HP:0001896)3.61482122
20Systemic lupus erythematosus (HP:0002725)3.54628117
21Petechiae (HP:0000967)3.54483637
22Recurrent fungal infections (HP:0002841)3.48107874
23Spontaneous hematomas (HP:0007420)3.47454890
24Prolonged bleeding time (HP:0003010)3.45894798
25Orchitis (HP:0100796)3.39727643
26Cellulitis (HP:0100658)3.28876232
27IgM deficiency (HP:0002850)3.26694495
28Agnosia (HP:0010524)3.19769582
29Stomatitis (HP:0010280)3.19133266
30Meningitis (HP:0001287)3.18813183
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.17531461
32T lymphocytopenia (HP:0005403)3.15794569
33Recurrent viral infections (HP:0004429)3.07418143
34Abnormality of T cell number (HP:0011839)3.06864205
35Epistaxis (HP:0000421)3.05571425
36Increased IgE level (HP:0003212)3.01671365
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.00532490
38Hypochromic microcytic anemia (HP:0004840)2.97448585
39Optic neuritis (HP:0100653)2.95003261
40Retrobulbar optic neuritis (HP:0100654)2.95003261
41Glomerulonephritis (HP:0000099)2.88849706
42Gingivitis (HP:0000230)2.88816924
43Chronic mucocutaneous candidiasis (HP:0002728)2.87912805
44Recurrent cutaneous fungal infections (HP:0011370)2.87912805
45Chronic otitis media (HP:0000389)2.87086097
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85107973
47Amyloidosis (HP:0011034)2.82683212
48Axonal loss (HP:0003447)2.82033752
49Basal ganglia calcification (HP:0002135)2.81368540
50Disinhibition (HP:0000734)2.80449402
51Vasculitis (HP:0002633)2.77992337
52Interstitial pulmonary disease (HP:0006530)2.77690323
53Abnormality of T cell physiology (HP:0011840)2.76572749
54Pallor (HP:0000980)2.75899038
55Hypochromic anemia (HP:0001931)2.75292000
56Loss of speech (HP:0002371)2.73736980
57Pulmonary embolism (HP:0002204)2.71748450
58Episodic fever (HP:0001954)2.70635971
59Abnormality of the prostate (HP:0008775)2.70420474
60Inflammation of the large intestine (HP:0002037)2.69788952
61Anorexia (HP:0002039)2.69711535
62Panhypogammaglobulinemia (HP:0003139)2.67226854
63Prostate neoplasm (HP:0100787)2.65908576
64Gastrointestinal inflammation (HP:0004386)2.62539654
65Pustule (HP:0200039)2.59407298
66Colitis (HP:0002583)2.58870038
67Gangrene (HP:0100758)2.57730130
68Increased IgM level (HP:0003496)2.55682966
69Purpura (HP:0000979)2.55216424
70Impaired platelet aggregation (HP:0003540)2.54532031
71Abnormal platelet function (HP:0011869)2.54532031
72Periodontitis (HP:0000704)2.53888866
73Autoimmune thrombocytopenia (HP:0001973)2.48468896
74Granulocytopenia (HP:0001913)2.46422310
75Urticaria (HP:0001025)2.46413888
76Abnormality of the pleura (HP:0002103)2.45212867
77Upper motor neuron abnormality (HP:0002127)2.38733897
78Aplastic anemia (HP:0001915)2.33907401
79Agammaglobulinemia (HP:0004432)2.31093722
80Gingival bleeding (HP:0000225)2.29755686
81Macrocytic anemia (HP:0001972)2.29178994
82Vertigo (HP:0002321)2.28161154
83Reduced antithrombin III activity (HP:0001976)2.28088844
84Sepsis (HP:0100806)2.27844009
85Arterial thrombosis (HP:0004420)2.26356939
86Hypergammaglobulinemia (HP:0010702)2.24124001
87Hepatosplenomegaly (HP:0001433)2.23902127
88Osteomyelitis (HP:0002754)2.22446142
89Polyneuropathy (HP:0001271)2.22161909
90Dysostosis multiplex (HP:0000943)2.22066083
91Albinism (HP:0001022)2.21061223
92Recurrent lower respiratory tract infections (HP:0002783)2.17777694
93Recurrent pneumonia (HP:0006532)2.14592642
94Glomerulopathy (HP:0100820)2.13334476
95Encephalitis (HP:0002383)2.11857905
96Eosinophilia (HP:0001880)2.11769947
97Joint hemorrhage (HP:0005261)2.11211300
98Abnormality of iron homeostasis (HP:0011031)2.10180659
99Leukocytosis (HP:0001974)2.09138367
100Chest pain (HP:0100749)2.08422239
101Thyroiditis (HP:0100646)2.08074489
102Hemoptysis (HP:0002105)2.07954830
103Mutism (HP:0002300)2.06924881
104Abnormality of T cells (HP:0002843)2.06838825
105Type I transferrin isoform profile (HP:0003642)2.05588153
106Microcytic anemia (HP:0001935)2.05463234
107Abnormality of the endocardium (HP:0004306)2.05023302
108Abnormality of eosinophils (HP:0001879)2.04802215
109Abnormality of the nasal mucosa (HP:0000433)2.03785698
110Keratoconjunctivitis sicca (HP:0001097)2.02804970
111Abnormality of the pericardium (HP:0001697)2.01949963
112Peritonitis (HP:0002586)2.01688917
113Keratitis (HP:0000491)1.99541523
114Premature loss of primary teeth (HP:0006323)1.96620217
115Pulmonary infiltrates (HP:0002113)1.95740258
116Acne (HP:0001061)1.93870268
117IgG deficiency (HP:0004315)1.92916197
118Lymphopenia (HP:0001888)1.92542332
119Nephritis (HP:0000123)1.92009491
120Poor head control (HP:0002421)1.91301388
121Progressive neurologic deterioration (HP:0002344)1.89993017
122Hematochezia (HP:0002573)1.89916886
123Abnormality of glycolipid metabolism (HP:0010969)1.89603586
124Abnormality of liposaccharide metabolism (HP:0010968)1.89603586
125Abnormality of glycosphingolipid metabolism (HP:0004343)1.89603586
126Exertional dyspnea (HP:0002875)1.89468594
127Menorrhagia (HP:0000132)1.88452859
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.88026703
129Arthralgia (HP:0002829)1.87093312
130Gastrointestinal stroma tumor (HP:0100723)1.86357387
131Recurrent bronchitis (HP:0002837)1.85912077
132Severe combined immunodeficiency (HP:0004430)1.85848439
133Skin ulcer (HP:0200042)1.85227262
134Increased serum ferritin (HP:0003281)1.84626345
135Keratoconjunctivitis (HP:0001096)1.84302072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.23629848
2RIPK43.15791047
3TGFBR23.03355354
4MAP4K12.99621203
5KIT2.97665260
6IRAK42.90321029
7NME22.72584647
8BTK2.42002375
9MAP2K32.41356693
10TEC2.38347162
11TBK12.24037009
12MUSK2.10185273
13TXK2.09227878
14TGFBR12.07612584
15TYK22.01910321
16IKBKE1.91521839
17ZAP701.82613596
18MAP3K141.80456682
19JAK31.77907526
20SYK1.75594823
21IRAK31.71725736
22IKBKB1.71441572
23MATK1.70291692
24MAP3K121.61070791
25CSF1R1.59972500
26GRK71.57539404
27FES1.55015486
28TNIK1.52652136
29LYN1.51328246
30CDK191.47169450
31TAOK11.44409307
32PIM21.41844547
33ACVR1B1.32855725
34CAMKK21.31633074
35ERN11.29058475
36MARK31.20877221
37PRPF4B1.18181472
38LCK1.15703564
39SIK21.13496631
40HCK1.12759235
41TAOK31.10552040
42CSK1.10506072
43TIE11.07709408
44BMPR1B1.05826505
45FLT31.05556623
46RPS6KA41.01355541
47PIM10.98689054
48CLK10.98510372
49CAMKK10.97295171
50SIK30.96044417
51WEE10.95465858
52MAP3K10.90274925
53EIF2AK20.88962511
54STK160.88557030
55CDK80.86296904
56EEF2K0.85321612
57PIK3CG0.85024740
58IRAK10.84165319
59NLK0.82640292
60MAPKAPK50.82225728
61MAP3K30.81887242
62TESK20.81583465
63MOS0.80972392
64KDR0.79957383
65BRSK20.79650685
66ADRBK20.79537223
67PASK0.77359791
68TAOK20.75049719
69TRPM70.74065803
70DYRK30.71715049
71PRKCQ0.71452784
72JAK10.69854610
73PRKG20.69219121
74TNK20.68716918
75EPHB10.68689796
76YES10.68406884
77STK100.67006166
78EIF2AK30.66972738
79MKNK10.66017559
80JAK20.65614216
81FGR0.65056154
82LRRK20.64804850
83MAP2K60.64384314
84MARK20.64201068
85PDPK10.63601467
86FYN0.63344479
87CAMK10.63020812
88MAP3K70.62038755
89MAPK70.61090051
90DAPK20.59235467
91MYLK0.58535251
92PRKCD0.58230137
93PRKD20.58181804
94ABL20.57808625
95MAPK40.57221470
96MAPK120.56446223
97IRAK20.55158654
98HIPK20.54338390
99CHUK0.53326063
100KSR20.51988395
101MST40.51458860
102RPS6KB20.50241387
103PTK2B0.49668853
104MAP2K20.48995008
105STK110.46093647
106PAK40.46044415
107PTK60.44811252
108RPS6KA50.44186457
109ITK0.44079149
110CCNB10.43241736
111CDC42BPA0.42989695
112VRK10.42615667
113MAP3K60.39916941
114SCYL20.39726047
115MAP3K50.39509422
116MAP3K130.39396390
117MAPKAPK20.37765258
118RPS6KA60.37521404
119MKNK20.37275799
120GRK60.35845787
121TLK10.35511121
122FRK0.34758976
123ABL10.34115147
124MAP3K110.33787692
125STK40.33591942
126BMPR20.32108389
127MAP2K40.30159950
128DYRK1B0.28814463
129PDK10.28206536
130NEK90.27345219
131RPS6KL10.26977456
132RPS6KC10.26977456
133STK380.23180511
134RPS6KA10.23036381
135ADRBK10.21477375
136MAP3K20.21295183
137OXSR10.18577545
138PRKCZ0.18244261

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.85278194
2Staphylococcus aureus infection_Homo sapiens_hsa051503.20794117
3Leishmaniasis_Homo sapiens_hsa051402.99642928
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.71933685
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36144260
6Osteoclast differentiation_Homo sapiens_hsa043802.33653200
7Pertussis_Homo sapiens_hsa051332.11747270
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09758261
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08878408
10B cell receptor signaling pathway_Homo sapiens_hsa046622.02533846
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.98499560
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.95691730
13Measles_Homo sapiens_hsa051621.95119159
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92698126
15Asthma_Homo sapiens_hsa053101.92068909
16Primary immunodeficiency_Homo sapiens_hsa053401.87777002
17Other glycan degradation_Homo sapiens_hsa005111.87501127
18Tuberculosis_Homo sapiens_hsa051521.80998525
19Legionellosis_Homo sapiens_hsa051341.78653447
20Allograft rejection_Homo sapiens_hsa053301.75131644
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74308651
22Graft-versus-host disease_Homo sapiens_hsa053321.70255922
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67550007
24Malaria_Homo sapiens_hsa051441.66764452
25Hematopoietic cell lineage_Homo sapiens_hsa046401.66046310
26Antigen processing and presentation_Homo sapiens_hsa046121.63859481
27Herpes simplex infection_Homo sapiens_hsa051681.59562215
28Lysosome_Homo sapiens_hsa041421.58179396
29Rheumatoid arthritis_Homo sapiens_hsa053231.56705958
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54476432
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.49429126
32Salmonella infection_Homo sapiens_hsa051321.47426521
33Chemokine signaling pathway_Homo sapiens_hsa040621.47224711
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.41991622
35DNA replication_Homo sapiens_hsa030301.40047918
36Caffeine metabolism_Homo sapiens_hsa002321.39872705
37Influenza A_Homo sapiens_hsa051641.39006295
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37397447
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26347502
40Shigellosis_Homo sapiens_hsa051311.24855365
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22953283
42Platelet activation_Homo sapiens_hsa046111.21574329
43Phagosome_Homo sapiens_hsa041451.20176403
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17835264
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12405522
46Toxoplasmosis_Homo sapiens_hsa051451.12363196
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12172834
48TNF signaling pathway_Homo sapiens_hsa046681.09624235
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04414132
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03891455
51Apoptosis_Homo sapiens_hsa042101.02857684
52African trypanosomiasis_Homo sapiens_hsa051430.94462279
53Acute myeloid leukemia_Homo sapiens_hsa052210.91485968
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91099403
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.89224458
56Hepatitis B_Homo sapiens_hsa051610.89046097
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85793957
58Autoimmune thyroid disease_Homo sapiens_hsa053200.84814830
59Base excision repair_Homo sapiens_hsa034100.78560240
60Arachidonic acid metabolism_Homo sapiens_hsa005900.78358339
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76290873
62Type I diabetes mellitus_Homo sapiens_hsa049400.74940860
63Pyrimidine metabolism_Homo sapiens_hsa002400.73461072
64Protein export_Homo sapiens_hsa030600.72058120
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71932993
66Collecting duct acid secretion_Homo sapiens_hsa049660.67682883
67Complement and coagulation cascades_Homo sapiens_hsa046100.67444563
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66850055
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65205019
70Homologous recombination_Homo sapiens_hsa034400.64853783
71Hepatitis C_Homo sapiens_hsa051600.64445930
72Mismatch repair_Homo sapiens_hsa034300.64148152
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62976495
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62678337
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61007398
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.58722426
77Epstein-Barr virus infection_Homo sapiens_hsa051690.58122643
78Non-small cell lung cancer_Homo sapiens_hsa052230.54404179
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54136404
80Endocytosis_Homo sapiens_hsa041440.52401567
81Folate biosynthesis_Homo sapiens_hsa007900.51593762
82RNA polymerase_Homo sapiens_hsa030200.50567890
83Proteasome_Homo sapiens_hsa030500.50557342
84N-Glycan biosynthesis_Homo sapiens_hsa005100.50549060
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50353362
86T cell receptor signaling pathway_Homo sapiens_hsa046600.47724592
87VEGF signaling pathway_Homo sapiens_hsa043700.47144815
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.44095424
89Systemic lupus erythematosus_Homo sapiens_hsa053220.43566317
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41640294
91HTLV-I infection_Homo sapiens_hsa051660.39998916
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.39108140
93Dorso-ventral axis formation_Homo sapiens_hsa043200.38425030
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38218436
95Regulation of autophagy_Homo sapiens_hsa041400.37585215
96Prolactin signaling pathway_Homo sapiens_hsa049170.37184567
97Nucleotide excision repair_Homo sapiens_hsa034200.36490960
98Viral carcinogenesis_Homo sapiens_hsa052030.36390269
99Sphingolipid metabolism_Homo sapiens_hsa006000.35992125
100Pentose phosphate pathway_Homo sapiens_hsa000300.35584155
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.35309812
102MAPK signaling pathway_Homo sapiens_hsa040100.34662278
103Pancreatic cancer_Homo sapiens_hsa052120.34491220
104Galactose metabolism_Homo sapiens_hsa000520.34048978
105Viral myocarditis_Homo sapiens_hsa054160.33880382
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33650796
107Type II diabetes mellitus_Homo sapiens_hsa049300.32418008
108Non-homologous end-joining_Homo sapiens_hsa034500.32189647
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.31051464
110Purine metabolism_Homo sapiens_hsa002300.30373341
111GnRH signaling pathway_Homo sapiens_hsa049120.30248774
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29928299
113Chronic myeloid leukemia_Homo sapiens_hsa052200.29914073
114HIF-1 signaling pathway_Homo sapiens_hsa040660.27986702
115p53 signaling pathway_Homo sapiens_hsa041150.27650165
116Spliceosome_Homo sapiens_hsa030400.25902104
117FoxO signaling pathway_Homo sapiens_hsa040680.25472662
118Amoebiasis_Homo sapiens_hsa051460.25128130
119Insulin resistance_Homo sapiens_hsa049310.23424535
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21443067
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20657357
122Choline metabolism in cancer_Homo sapiens_hsa052310.20231174
123Renal cell carcinoma_Homo sapiens_hsa052110.19432582
124Notch signaling pathway_Homo sapiens_hsa043300.19237423
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16956603
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15522593

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