LTA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.34871388
2regulation of interleukin-12 biosynthetic process (GO:0045075)6.12359661
3positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.07920056
4regulation of isotype switching to IgG isotypes (GO:0048302)5.90861020
5response to interleukin-15 (GO:0070672)5.86234794
6DNA deamination (GO:0045006)5.74271305
7regulation of gamma-delta T cell differentiation (GO:0045586)5.52423739
8tyrosine phosphorylation of STAT protein (GO:0007260)5.46133851
9cytidine deamination (GO:0009972)5.45795356
10cytidine metabolic process (GO:0046087)5.45795356
11cytidine catabolic process (GO:0006216)5.45795356
12negative T cell selection (GO:0043383)5.19337187
13positive regulation of T cell cytokine production (GO:0002726)5.15837190
14antigen processing and presentation of endogenous antigen (GO:0019883)5.09697157
15cellular response to interleukin-15 (GO:0071350)5.08943522
16negative thymic T cell selection (GO:0045060)5.08700713
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07086991
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07086991
19regulation of interleukin-2 biosynthetic process (GO:0045076)4.99310523
20regulation of gamma-delta T cell activation (GO:0046643)4.94744455
21positive regulation of isotype switching (GO:0045830)4.90186576
22regulation of regulatory T cell differentiation (GO:0045589)4.72527952
23interferon-gamma production (GO:0032609)4.70591246
24pyrimidine ribonucleoside catabolic process (GO:0046133)4.69793791
25positive thymic T cell selection (GO:0045059)4.60996736
26regulation of immunoglobulin secretion (GO:0051023)4.50606293
27* positive regulation of B cell mediated immunity (GO:0002714)4.46689626
28* positive regulation of immunoglobulin mediated immune response (GO:0002891)4.46689626
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.43671679
30regulation of response to tumor cell (GO:0002834)4.37762592
31positive regulation of response to tumor cell (GO:0002836)4.37762592
32positive regulation of immune response to tumor cell (GO:0002839)4.37762592
33regulation of immune response to tumor cell (GO:0002837)4.37762592
34regulation of alpha-beta T cell proliferation (GO:0046640)4.32759741
35myeloid dendritic cell differentiation (GO:0043011)4.30560882
36positive regulation of immunoglobulin production (GO:0002639)4.28319981
37positive regulation of interleukin-2 production (GO:0032743)4.26697673
38positive regulation of natural killer cell differentiation (GO:0032825)4.21968074
39JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.20643498
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.19920258
41positive regulation of DNA recombination (GO:0045911)4.18495399
42positive T cell selection (GO:0043368)4.15580240
43* regulation of chronic inflammatory response (GO:0002676)4.11471221
44tolerance induction (GO:0002507)4.08370646
45thymic T cell selection (GO:0045061)4.05950688
46positive regulation of alpha-beta T cell proliferation (GO:0046641)4.05072114
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98430429
48maturation of 5.8S rRNA (GO:0000460)3.94250685
49positive regulation of natural killer cell mediated immunity (GO:0002717)3.92841355
50positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.92841355
51myeloid dendritic cell activation (GO:0001773)3.91164620
52positive regulation of activated T cell proliferation (GO:0042104)3.90731168
53activated T cell proliferation (GO:0050798)3.88561761
54T cell lineage commitment (GO:0002360)3.85683133
55regulation of immunoglobulin production (GO:0002637)3.84490741
56T cell selection (GO:0045058)3.84362600
57positive regulation of defense response to virus by host (GO:0002230)3.80774434
58negative regulation of T cell mediated immunity (GO:0002710)3.79763879
59regulation of interleukin-2 production (GO:0032663)3.77077895
60NIK/NF-kappaB signaling (GO:0038061)3.75972580
61leukocyte aggregation (GO:0070486)3.73816799
62regulation of isotype switching (GO:0045191)3.72961124
63positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.72112899
64CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.71485859
65folic acid-containing compound biosynthetic process (GO:0009396)3.70959754
66positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.68790833
67rRNA modification (GO:0000154)3.68570870
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.68309922
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.65859429
70regulation of natural killer cell mediated immunity (GO:0002715)3.65859429
71* regulation of immunoglobulin mediated immune response (GO:0002889)3.64305408
72T cell costimulation (GO:0031295)3.63020832
73T cell migration (GO:0072678)3.61810389
74regulation of T cell chemotaxis (GO:0010819)3.59755469
75positive regulation of T cell chemotaxis (GO:0010820)3.59755469
76T cell homeostasis (GO:0043029)3.57848900
77regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.57520849
78positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.57520849
79* regulation of B cell mediated immunity (GO:0002712)3.57032143
80lymphocyte costimulation (GO:0031294)3.55101952
81positive regulation of cell killing (GO:0031343)3.54217393
82regulation of T cell cytokine production (GO:0002724)3.53780593
83* positive regulation of lymphocyte mediated immunity (GO:0002708)3.50334962
84positive regulation of interleukin-17 production (GO:0032740)3.49279328
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49278110
86T cell receptor signaling pathway (GO:0050852)3.46140696
87regulation of cellular amino acid metabolic process (GO:0006521)3.46026288
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.45533849
89negative regulation of T-helper cell differentiation (GO:0045623)3.45533849
90rRNA methylation (GO:0031167)3.45431820
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.42107893
92negative regulation of cell killing (GO:0031342)3.42107893
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41462925
94regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.40832778
95negative regulation of interleukin-12 production (GO:0032695)3.36560155
96proteasome assembly (GO:0043248)3.36431147
97regulation of leukocyte mediated cytotoxicity (GO:0001910)3.36341548
98mast cell activation (GO:0045576)3.35859391
99regulation of B cell receptor signaling pathway (GO:0050855)3.34986134
100regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.33868622
101mucosal-associated lymphoid tissue development (GO:0048537)3.32073627
102Peyers patch development (GO:0048541)3.32073627
103antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.30462257
104positive regulation of macrophage differentiation (GO:0045651)3.29347119
105positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27265949
106positive regulation of T-helper 1 type immune response (GO:0002827)3.26864599
107regulation of T-helper 1 type immune response (GO:0002825)3.25623649
108regulation of B cell differentiation (GO:0045577)3.25376110
109defense response to protozoan (GO:0042832)3.24514122
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22563376
111natural killer cell differentiation (GO:0001779)3.22043854
112T cell proliferation (GO:0042098)3.21464406
113DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20635276
114regulation of cell killing (GO:0031341)3.20412319
115natural killer cell activation (GO:0030101)3.20369233
116positive regulation of interleukin-10 production (GO:0032733)3.19588413
117* regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15936110
118negative regulation of nitric oxide biosynthetic process (GO:0045019)3.15395910
119regulation of T cell mediated cytotoxicity (GO:0001914)3.14171206
120positive regulation of production of molecular mediator of immune response (GO:0002702)3.13652057
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13133388
122signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13133388
123antigen receptor-mediated signaling pathway (GO:0050851)3.12715621
124regulation of T cell tolerance induction (GO:0002664)3.11868769
125hepatocyte apoptotic process (GO:0097284)3.10921984
126signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10157925
127signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10157925
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10157925
129positive regulation of T cell proliferation (GO:0042102)3.10024053
130ribosome assembly (GO:0042255)3.09295912
131T cell apoptotic process (GO:0070231)3.09096005
132regulation of lymphocyte chemotaxis (GO:1901623)3.08884712
133response to protozoan (GO:0001562)3.08784312
134regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.08391912
135regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.08308820
136positive regulation of astrocyte differentiation (GO:0048711)3.07383120
137positive regulation of cytokine biosynthetic process (GO:0042108)3.06380482
138cellular response to interleukin-4 (GO:0071353)3.06053524
139positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.04693844
140rRNA processing (GO:0006364)3.04424095
141signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98470340
142signal transduction involved in DNA damage checkpoint (GO:0072422)2.98470340
143positive regulation of prostaglandin secretion (GO:0032308)2.95650434
144* positive regulation of humoral immune response (GO:0002922)2.93241223
145signal transduction involved in cell cycle checkpoint (GO:0072395)2.92214026
146T cell differentiation involved in immune response (GO:0002292)2.91387072
147alpha-beta T cell differentiation involved in immune response (GO:0002293)2.91387072
148alpha-beta T cell activation involved in immune response (GO:0002287)2.91387072
149rRNA metabolic process (GO:0016072)2.91306475
150T-helper cell differentiation (GO:0042093)2.88517329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.05684327
2E2F7_22180533_ChIP-Seq_HELA_Human5.74974878
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.69183506
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.25149298
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.12319081
6MYC_22102868_ChIP-Seq_BL_Human3.89711782
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82354229
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81650674
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.62179204
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.44664932
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.37944510
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.20505286
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11545650
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97851580
15* MYB_26560356_Chip-Seq_TH2_Human2.71725441
16RUNX_20019798_ChIP-Seq_JUKART_Human2.70432513
17MAF_26560356_Chip-Seq_TH1_Human2.64762170
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.64409167
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62591522
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61897760
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.52689422
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50803948
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49317590
24MYB_26560356_Chip-Seq_TH1_Human2.49100789
25VDR_21846776_ChIP-Seq_THP-1_Human2.36473906
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.31425821
27UTX_26944678_Chip-Seq_JUKART_Human2.18011123
28GATA1_22025678_ChIP-Seq_K562_Human2.17268841
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16506103
30* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14807252
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06045925
32MAF_26560356_Chip-Seq_TH2_Human1.99394499
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95893723
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91556592
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90477813
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87668017
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86698364
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85934474
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.85241305
40TCF7_22412390_ChIP-Seq_EML_Mouse1.80949598
41VDR_24763502_ChIP-Seq_THP-1_Human1.79917906
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74889097
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74888944
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72444350
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.69925248
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.68147941
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68061039
48* GATA3_27048872_Chip-Seq_THYMUS_Human1.67361855
49SPI1_23547873_ChIP-Seq_NB4_Human1.64683210
50KDM2B_26808549_Chip-Seq_DND41_Human1.63707241
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63153736
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.61258479
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59681439
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58654311
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.58580016
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55075098
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54560329
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48393055
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47731431
60DCP1A_22483619_ChIP-Seq_HELA_Human1.43522865
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42842644
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.41143225
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.40050357
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37979192
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36990105
66* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35228294
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32503242
68GABP_19822575_ChIP-Seq_HepG2_Human1.32027859
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31820382
70CIITA_25753668_ChIP-Seq_RAJI_Human1.31487251
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22213044
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21505617
73TTF2_22483619_ChIP-Seq_HELA_Human1.21432204
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21363817
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20211690
76VDR_23849224_ChIP-Seq_CD4+_Human1.18460734
77SCL_19346495_ChIP-Seq_HPC-7_Human1.16362762
78IRF1_19129219_ChIP-ChIP_H3396_Human1.15257779
79SPI1_23127762_ChIP-Seq_K562_Human1.14818625
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.12722019
81FOXP3_21729870_ChIP-Seq_TREG_Human1.09415447
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08493729
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.08137838
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06146592
85XRN2_22483619_ChIP-Seq_HELA_Human1.06053401
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06016759
87PU_27001747_Chip-Seq_BMDM_Mouse1.05262141
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04181647
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99656232
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99111646
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98543410
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98539209
93* GATA3_26560356_Chip-Seq_TH2_Human0.97727470
94E2F1_21310950_ChIP-Seq_MCF-7_Human0.97654376
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97093459
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96246113
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.95345542
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94506301
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94023446
100MYC_18940864_ChIP-ChIP_HL60_Human0.93845519
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93309007
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92168218
103PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91363852
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91193950
105KDM5A_27292631_Chip-Seq_BREAST_Human0.90423836
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89405204
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87334551
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86297575
109ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85187028
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85105597
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84991331
112E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84721496
113MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83958453
114FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83688767
115ELF5_23300383_ChIP-Seq_T47D_Human0.83584479
116ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83128961
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83045185
118ELK1_19687146_ChIP-ChIP_HELA_Human0.82896168
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82755246
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80775813
121* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80234171
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79517649
123RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79245674
124EGR1_19032775_ChIP-ChIP_M12_Human0.79038999
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79029858
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78555847
127NCOR1_26117541_ChIP-Seq_K562_Human0.78515286
128HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77054591
129* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76655882
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75304607
131* GATA3_26560356_Chip-Seq_TH1_Human0.73849615
132VDR_22108803_ChIP-Seq_LS180_Human0.73481129
133MYC_18358816_ChIP-ChIP_MESCs_Mouse0.72658435
134RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72548296
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72267955
136* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70897572
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.69751580
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68395511
139* SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.68067594
140GABP_17652178_ChIP-ChIP_JURKAT_Human0.66232062
141EST1_17652178_ChIP-ChIP_JURKAT_Human0.65757913
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.65584070
143ETS1_20019798_ChIP-Seq_JURKAT_Human0.65543013
144CREB1_15753290_ChIP-ChIP_HEK293T_Human0.65494588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.32246629
2MP0005671_abnormal_response_to4.26622598
3MP0001835_abnormal_antigen_presentation4.14450382
4MP0001790_abnormal_immune_system3.58144866
5MP0005387_immune_system_phenotype3.58144866
6* MP0001800_abnormal_humoral_immune3.54153631
7* MP0000685_abnormal_immune_system3.27580117
8MP0003300_gastrointestinal_ulcer3.24236383
9* MP0005000_abnormal_immune_tolerance3.01278043
10* MP0003436_decreased_susceptibility_to3.00309653
11* MP0002723_abnormal_immune_serum2.92111030
12MP0009333_abnormal_splenocyte_physiolog2.89063289
13MP0003866_abnormal_defecation2.86818200
14* MP0009785_altered_susceptibility_to2.85394466
15* MP0002452_abnormal_antigen_presenting2.74814968
16MP0002396_abnormal_hematopoietic_system2.73343900
17* MP0002398_abnormal_bone_marrow2.72539738
18MP0003303_peritoneal_inflammation2.70607862
19* MP0002420_abnormal_adaptive_immunity2.67017062
20* MP0001819_abnormal_immune_cell2.62569674
21* MP0002405_respiratory_system_inflammati2.60411553
22* MP0005025_abnormal_response_to2.52185438
23MP0002166_altered_tumor_susceptibility2.49742616
24MP0010155_abnormal_intestine_physiology2.44019209
25MP0002148_abnormal_hypersensitivity_rea2.35445410
26MP0001853_heart_inflammation2.34440610
27* MP0000716_abnormal_immune_system2.33712274
28MP0002006_tumorigenesis2.28169342
29MP0006082_CNS_inflammation2.21504346
30* MP0000689_abnormal_spleen_morphology2.21002792
31MP0004510_myositis2.19509062
32* MP0000703_abnormal_thymus_morphology2.19421065
33* MP0002722_abnormal_immune_system2.14007010
34MP0001873_stomach_inflammation1.99708659
35MP0005645_abnormal_hypothalamus_physiol1.98518879
36MP0002933_joint_inflammation1.97946673
37* MP0002429_abnormal_blood_cell1.93579835
38* MP0002419_abnormal_innate_immunity1.76677244
39MP0004808_abnormal_hematopoietic_stem1.75113789
40* MP0001845_abnormal_inflammatory_respons1.73827569
41MP0004947_skin_inflammation1.72789802
42MP0003724_increased_susceptibility_to1.70603721
43MP0008057_abnormal_DNA_replication1.55489606
44MP0003806_abnormal_nucleotide_metabolis1.44467448
45MP0002254_reproductive_system_inflammat1.42003897
46MP0010352_gastrointestinal_tract_polyps1.30614699
47MP0005464_abnormal_platelet_physiology1.30051273
48MP0003646_muscle_fatigue1.25844505
49MP0005310_abnormal_salivary_gland1.22479011
50MP0008872_abnormal_physiological_respon1.21059040
51MP0003448_altered_tumor_morphology1.20469288
52MP0000490_abnormal_crypts_of1.19882755
53MP0000465_gastrointestinal_hemorrhage1.18985543
54MP0005076_abnormal_cell_differentiation1.16562289
55MP0000858_altered_metastatic_potential1.13234919
56* MP0001533_abnormal_skeleton_physiology1.10906121
57MP0002019_abnormal_tumor_incidence1.10834175
58MP0000604_amyloidosis1.09782539
59MP0002138_abnormal_hepatobiliary_system1.09348200
60* MP0008469_abnormal_protein_level1.09103322
61MP0003045_fibrosis1.05652978
62MP0010307_abnormal_tumor_latency1.05250903
63MP0001881_abnormal_mammary_gland1.03636166
64MP0004145_abnormal_muscle_electrophysio1.02989553
65MP0002876_abnormal_thyroid_physiology1.00585298
66MP0010094_abnormal_chromosome_stability1.00504995
67MP0003077_abnormal_cell_cycle0.99519334
68MP0005397_hematopoietic_system_phenotyp0.98019165
69MP0001545_abnormal_hematopoietic_system0.98019165
70MP0008961_abnormal_basal_metabolism0.93296276
71MP0004957_abnormal_blastocyst_morpholog0.92428799
72MP0003693_abnormal_embryo_hatching0.92351053
73MP0001919_abnormal_reproductive_system0.88091762
74MP0005379_endocrine/exocrine_gland_phen0.86628316
75MP0004381_abnormal_hair_follicle0.86054726
76MP0005408_hypopigmentation0.85570309
77MP0002998_abnormal_bone_remodeling0.81576492
78MP0005451_abnormal_body_composition0.80676152
79MP0004142_abnormal_muscle_tone0.80252883
80MP0001727_abnormal_embryo_implantation0.79567824
81MP0006036_abnormal_mitochondrial_physio0.75438361
82MP0001661_extended_life_span0.73378201
83MP0003959_abnormal_lean_body0.70872186
84MP0004742_abnormal_vestibular_system0.69696076
85MP0000627_abnormal_mammary_gland0.67569302
86MP0000350_abnormal_cell_proliferation0.66624965
87MP0001851_eye_inflammation0.66439976
88MP0003111_abnormal_nucleus_morphology0.66021277
89MP0004782_abnormal_surfactant_physiolog0.65863557
90MP0008875_abnormal_xenobiotic_pharmacok0.65368239
91MP0002132_abnormal_respiratory_system0.65336664
92MP0003453_abnormal_keratinocyte_physiol0.63035134
93MP0005075_abnormal_melanosome_morpholog0.61965312
94MP0001765_abnormal_ion_homeostasis0.60272437
95MP0002139_abnormal_hepatobiliary_system0.59745716
96MP0002163_abnormal_gland_morphology0.59573409
97* MP0009764_decreased_sensitivity_to0.59444896
98MP0000313_abnormal_cell_death0.58834399
99MP0002277_abnormal_respiratory_mucosa0.58822466
100MP0002332_abnormal_exercise_endurance0.58286643
101MP0009278_abnormal_bone_marrow0.57283069
102MP0001663_abnormal_digestive_system0.56311379
103MP0005166_decreased_susceptibility_to0.55470607
104MP0003091_abnormal_cell_migration0.55111681
105MP0006035_abnormal_mitochondrial_morpho0.54258688
106MP0005023_abnormal_wound_healing0.54094625
107MP0000477_abnormal_intestine_morphology0.54032839
108MP0005584_abnormal_enzyme/coenzyme_acti0.54024414
109MP0001730_embryonic_growth_arrest0.53974928
110MP0009765_abnormal_xenobiotic_induced0.53343191
111MP0003878_abnormal_ear_physiology0.52857755
112MP0005377_hearing/vestibular/ear_phenot0.52857755
113MP0005381_digestive/alimentary_phenotyp0.51959386
114MP0005636_abnormal_mineral_homeostasis0.51611299
115MP0000371_diluted_coat_color0.51278094
116* MP0000609_abnormal_liver_physiology0.50907447
117MP0001346_abnormal_lacrimal_gland0.50861281
118MP0003786_premature_aging0.50598810
119MP0005319_abnormal_enzyme/_coenzyme0.47805853
120* MP0009763_increased_sensitivity_to0.47668036
121MP0008007_abnormal_cellular_replicative0.46639584
122MP0000249_abnormal_blood_vessel0.45678147
123MP0002693_abnormal_pancreas_physiology0.45647362
124MP0001348_abnormal_lacrimal_gland0.45158389
125MP0003795_abnormal_bone_structure0.45004922
126MP0002136_abnormal_kidney_physiology0.44859452
127MP0001216_abnormal_epidermal_layer0.42121404
128MP0002088_abnormal_embryonic_growth/wei0.40917473
129MP0008058_abnormal_DNA_repair0.40632939
130MP0002083_premature_death0.39782551
131MP0003943_abnormal_hepatobiliary_system0.39354520
132MP0003984_embryonic_growth_retardation0.38619369

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.36176617
2Abnormality of T cell number (HP:0011839)6.25240079
3Stomatitis (HP:0010280)6.06040558
4Elevated erythrocyte sedimentation rate (HP:0003565)5.81425509
5Recurrent fungal infections (HP:0002841)5.18251001
6IgA deficiency (HP:0002720)5.15761849
7Abnormality of T cells (HP:0002843)5.15184426
8Recurrent bronchitis (HP:0002837)5.04069919
9Recurrent viral infections (HP:0004429)4.99339937
10Chronic diarrhea (HP:0002028)4.69557037
11Chronic mucocutaneous candidiasis (HP:0002728)4.60841098
12Recurrent cutaneous fungal infections (HP:0011370)4.60841098
13Panhypogammaglobulinemia (HP:0003139)4.57526560
14Eczematoid dermatitis (HP:0000976)4.38078547
15Nasal polyposis (HP:0100582)4.32125010
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.28947448
17Chronic otitis media (HP:0000389)4.23946926
18IgM deficiency (HP:0002850)4.09898036
19Acute necrotizing encephalopathy (HP:0006965)4.06194226
20IgG deficiency (HP:0004315)4.01367532
21Abnormality of T cell physiology (HP:0011840)3.97456911
22Severe combined immunodeficiency (HP:0004430)3.96167120
23Acute encephalopathy (HP:0006846)3.88225742
24Combined immunodeficiency (HP:0005387)3.86172483
25Thrombocytosis (HP:0001894)3.74577105
26Increased IgM level (HP:0003496)3.73707167
27Increased hepatocellular lipid droplets (HP:0006565)3.71959057
28Increased density of long bones (HP:0006392)3.69561458
29Agammaglobulinemia (HP:0004432)3.61424948
30Mediastinal lymphadenopathy (HP:0100721)3.54908905
31Autoimmune thrombocytopenia (HP:0001973)3.52751131
32Abnormality of the nasal mucosa (HP:0000433)3.51747842
33Abnormal mitochondria in muscle tissue (HP:0008316)3.51018767
34Vasculitis (HP:0002633)3.43600832
35Lipid accumulation in hepatocytes (HP:0006561)3.37840202
36Lymphopenia (HP:0001888)3.34221011
37Gastrointestinal infarctions (HP:0005244)3.34042234
38Gastrointestinal stroma tumor (HP:0100723)3.33157037
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.31360619
40Progressive macrocephaly (HP:0004481)3.26888446
41Joint swelling (HP:0001386)3.25280685
42Abnormality of the fingertips (HP:0001211)3.23779374
43Inflammation of the large intestine (HP:0002037)3.21082866
44Gastrointestinal inflammation (HP:0004386)3.19330658
45Increased CSF lactate (HP:0002490)3.16578338
46Anorexia (HP:0002039)3.10359365
47Myositis (HP:0100614)3.07881532
48Meningitis (HP:0001287)3.05123741
49Lymphoma (HP:0002665)3.01049930
50Pulmonary infiltrates (HP:0002113)3.00688935
51Mitochondrial inheritance (HP:0001427)2.96936252
52Recurrent sinusitis (HP:0011108)2.95596659
53Cellulitis (HP:0100658)2.94763596
54Chronic sinusitis (HP:0011109)2.90216470
55Autoimmune hemolytic anemia (HP:0001890)2.89348243
56Abnormality of B cell number (HP:0010975)2.85405156
57B lymphocytopenia (HP:0010976)2.85405156
58Persistence of primary teeth (HP:0006335)2.83425692
59Hemoptysis (HP:0002105)2.82348045
60Cheilitis (HP:0100825)2.82077045
61Gangrene (HP:0100758)2.80086006
62Bronchitis (HP:0012387)2.77732280
63Recurrent skin infections (HP:0001581)2.73486828
64Abnormal pupillary function (HP:0007686)2.72299051
65Increased intramyocellular lipid droplets (HP:0012240)2.72208672
66Hypergammaglobulinemia (HP:0010702)2.71770196
67Arterial thrombosis (HP:0004420)2.70629580
68Renal Fanconi syndrome (HP:0001994)2.68554043
69Abnormality of the anterior horn cell (HP:0006802)2.63536134
70Degeneration of anterior horn cells (HP:0002398)2.63536134
71Emphysema (HP:0002097)2.63129902
72Premature loss of primary teeth (HP:0006323)2.62875026
73Keratoconjunctivitis (HP:0001096)2.61185732
74Verrucae (HP:0200043)2.61160536
75Papilloma (HP:0012740)2.61160536
76Pancytopenia (HP:0001876)2.59182221
77Interstitial pulmonary disease (HP:0006530)2.59025934
78Thyroiditis (HP:0100646)2.58676001
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58128695
80Leukocytosis (HP:0001974)2.52132854
81Oral leukoplakia (HP:0002745)2.49762826
82Cerebral edema (HP:0002181)2.49373643
83Fatigue (HP:0012378)2.48114674
84Keratoconjunctivitis sicca (HP:0001097)2.46215190
85Chest pain (HP:0100749)2.44981190
86Recurrent abscess formation (HP:0002722)2.43470663
87Pustule (HP:0200039)2.42661997
88Optic neuritis (HP:0100653)2.42580225
89Retrobulbar optic neuritis (HP:0100654)2.42580225
90Increased IgE level (HP:0003212)2.41584102
91Amaurosis fugax (HP:0100576)2.37255017
92Abnormality of eosinophils (HP:0001879)2.35658094
93Eosinophilia (HP:0001880)2.35042999
94Aplastic anemia (HP:0001915)2.34851407
95Nausea (HP:0002018)2.28432124
96Increased muscle lipid content (HP:0009058)2.28403160
97Reduced subcutaneous adipose tissue (HP:0003758)2.24851551
98Obstructive lung disease (HP:0006536)2.24849900
99Chronic obstructive pulmonary disease (HP:0006510)2.24849900
100Abnormality of the pons (HP:0007361)2.24739145
101Exertional dyspnea (HP:0002875)2.19850160
102Optic disc pallor (HP:0000543)2.19737376
103Arthralgia (HP:0002829)2.18945238
104Colitis (HP:0002583)2.17252083
1053-Methylglutaconic aciduria (HP:0003535)2.16969588
106Increased serum lactate (HP:0002151)2.15827693
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13283018
108Leukopenia (HP:0001882)2.10943299
109Hepatosplenomegaly (HP:0001433)2.10524035
110Osteomyelitis (HP:0002754)2.09540524
111Granulocytopenia (HP:0001913)2.08547858
112Skin ulcer (HP:0200042)2.05096765
113Gingival bleeding (HP:0000225)2.04635285
114Hypertensive crisis (HP:0100735)2.03396208
115Hypoplasia of the thymus (HP:0000778)2.03358553
116Orchitis (HP:0100796)2.01106332
117Hypoplasia of the pons (HP:0012110)2.00789361
118Porencephaly (HP:0002132)1.99439009
119Recurrent bacterial skin infections (HP:0005406)1.99131093
120Restrictive lung disease (HP:0002091)1.98885753
121Leukodystrophy (HP:0002415)1.96923394
122Hepatocellular necrosis (HP:0001404)1.96595602
123Basal ganglia calcification (HP:0002135)1.96334249
124Acute myeloid leukemia (HP:0004808)1.95657198
125Basal cell carcinoma (HP:0002671)1.95618044
126Myocardial infarction (HP:0001658)1.95588418
127Cutis marmorata (HP:0000965)1.95176801
128Respiratory difficulties (HP:0002880)1.94533850
129Exercise intolerance (HP:0003546)1.94176886
130Chronic hepatic failure (HP:0100626)1.94059374
131Encephalitis (HP:0002383)1.93948685
132Abnormal gallbladder physiology (HP:0012438)1.93454025
133Cholecystitis (HP:0001082)1.93454025
134Duplicated collecting system (HP:0000081)1.92081326
135Hepatic necrosis (HP:0002605)1.91612543
136Methylmalonic acidemia (HP:0002912)1.91410277
137Hypoproteinemia (HP:0003075)1.90420878
138Paralysis (HP:0003470)1.88200374
139Methylmalonic aciduria (HP:0012120)1.87427723
140Aplasia/hypoplasia of the uterus (HP:0008684)1.86876110
141Acrocyanosis (HP:0001063)1.83293808
142Periodontitis (HP:0000704)1.81311356
143Spontaneous hematomas (HP:0007420)1.81260505
144Recurrent otitis media (HP:0000403)1.81183995
145Somatic mutation (HP:0001428)1.79769840
146Recurrent lower respiratory tract infections (HP:0002783)1.74501396
147Skin rash (HP:0000988)1.74480816
148Poikiloderma (HP:0001029)1.74022668
149Hepatitis (HP:0012115)1.70730660
150Abnormality of the endocardium (HP:0004306)1.67432880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.21787399
2TXK4.98792228
3JAK34.17098540
4SRPK13.61532429
5ZAP703.22104707
6MAPKAPK33.18050182
7MAP3K143.02172624
8EEF2K2.95850087
9EIF2AK32.84332696
10TLK12.77855593
11TRIM282.75632645
12ITK2.65492607
13EIF2AK12.33753299
14IKBKE2.25233225
15TYK22.16525934
16WNK42.13300961
17FGFR42.13091590
18BUB12.10084913
19PIM22.06646532
20TBK11.99722441
21TRIB31.89202659
22TAOK31.83619149
23STK101.80326321
24BLK1.79355623
25IKBKB1.76088834
26TEC1.75893708
27BTK1.74330504
28MAP3K101.71921724
29SYK1.70446343
30LCK1.64463318
31EIF2AK21.61599420
32CHUK1.61263370
33JAK11.60071103
34VRK21.55114142
35FGFR31.52007498
36PKN21.45070981
37MST41.44867978
38HCK1.44766018
39CSK1.43969219
40CDK121.43586304
41NLK1.40842802
42MAP3K131.29347530
43GRK61.28824564
44RPS6KA41.26245740
45ADRBK21.22568245
46PRKCH1.20728394
47NME21.19259505
48CLK11.16796889
49ALK1.15569261
50PIM11.14901166
51SIK21.10294430
52DAPK11.10237445
53WNK11.09593979
54SMG11.08542634
55MAP3K71.07779146
56VRK11.00471882
57JAK20.99273529
58MAP2K60.98949079
59LRRK20.97549140
60PRKCQ0.97096670
61LYN0.95700709
62TAOK10.94705893
63CAMKK20.94306352
64EPHA30.88195116
65PASK0.87684118
66TSSK60.85562686
67MAP3K110.85339385
68ZAK0.80902042
69CDK40.80231361
70STK390.80156051
71EPHB10.80098340
72MAP3K120.78739575
73NEK10.78689049
74RAF10.78575732
75CDC70.75100413
76CSF1R0.72854754
77IRAK40.71387114
78KIT0.68393276
79PLK30.65419777
80MAPK110.62485959
81NEK60.62478342
82FES0.62227286
83MAP3K80.58979088
84MARK30.56031300
85BCKDK0.54446120
86NUAK10.54237315
87STK160.53858901
88MAP2K30.53435259
89NEK20.51888819
90SIK30.50063102
91RIPK40.50011858
92CDC42BPA0.48781722
93TGFBR10.48224107
94FGFR10.47496348
95SIK10.47113791
96OXSR10.46981482
97PDK10.46743756
98MAP3K90.46369440
99MAPKAPK20.45711683
100PIK3CG0.44991847
101TNK20.44835659
102KDR0.44439484
103ERN10.44225777
104IRAK10.43594522
105PAK20.43470070
106PBK0.42991037
107TAF10.42479877
108CHEK10.40708464
109EGFR0.40616435
110PRKCI0.39768677
111MAP3K50.39763923
112CAMKK10.38174508
113BRD40.37824975
114PTK60.36935538
115NEK90.36847327
116CDK190.35864992
117RPS6KB10.35110449
118TESK20.34603342
119INSR0.33684201
120HIPK20.31835157
121RPS6KA50.31541226
122CSNK2A20.31123203
123BMX0.30798383
124RPS6KA10.30421755
125MARK20.29123710
126ABL10.28661414
127CDK70.28168312
128MELK0.27719860
129STK40.27373347
130MAPK40.25607274
131TAOK20.25436507
132CSNK1G30.24230315
133MTOR0.23255948
134SCYL20.23162175
135PRKCB0.22321124
136ATR0.22078648
137TTN0.21970119
138NME10.21578118
139BMPR20.21359107
140CDK90.20814538
141CDK60.20582436
142IRAK30.17709396

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.24382020
2Allograft rejection_Homo sapiens_hsa053303.77031719
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.60723235
4Graft-versus-host disease_Homo sapiens_hsa053323.40213007
5T cell receptor signaling pathway_Homo sapiens_hsa046603.05230663
6* NF-kappa B signaling pathway_Homo sapiens_hsa040642.95001008
7Measles_Homo sapiens_hsa051622.68572015
8Asthma_Homo sapiens_hsa053102.52469472
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.44593614
10Autoimmune thyroid disease_Homo sapiens_hsa053202.44127601
11Jak-STAT signaling pathway_Homo sapiens_hsa046302.32607535
12* Type I diabetes mellitus_Homo sapiens_hsa049402.28891550
13B cell receptor signaling pathway_Homo sapiens_hsa046622.09349894
14Leishmaniasis_Homo sapiens_hsa051402.06321268
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99296473
16RNA polymerase_Homo sapiens_hsa030201.92068734
17Antigen processing and presentation_Homo sapiens_hsa046121.83726106
18Osteoclast differentiation_Homo sapiens_hsa043801.83648473
19Hematopoietic cell lineage_Homo sapiens_hsa046401.82131457
20Viral myocarditis_Homo sapiens_hsa054161.75453364
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68980454
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68629950
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61248492
24* Herpes simplex infection_Homo sapiens_hsa051681.53574946
25Acute myeloid leukemia_Homo sapiens_hsa052211.50124269
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48560212
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45561095
28Toxoplasmosis_Homo sapiens_hsa051451.44141920
29* TNF signaling pathway_Homo sapiens_hsa046681.37576459
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36057579
31Chemokine signaling pathway_Homo sapiens_hsa040621.30809390
32Prolactin signaling pathway_Homo sapiens_hsa049171.30065046
33Protein export_Homo sapiens_hsa030601.30000177
34Legionellosis_Homo sapiens_hsa051341.28335426
35Influenza A_Homo sapiens_hsa051641.27765398
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26515478
37Hepatitis B_Homo sapiens_hsa051611.26251230
38Chronic myeloid leukemia_Homo sapiens_hsa052201.20479265
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18495439
40* HTLV-I infection_Homo sapiens_hsa051661.16785704
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15303263
42DNA replication_Homo sapiens_hsa030301.13160119
43Epstein-Barr virus infection_Homo sapiens_hsa051691.12556283
44Oxidative phosphorylation_Homo sapiens_hsa001901.09217216
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08646238
46Apoptosis_Homo sapiens_hsa042101.05049973
47One carbon pool by folate_Homo sapiens_hsa006701.04103445
48Parkinsons disease_Homo sapiens_hsa050120.98930024
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98097208
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96689797
51Shigellosis_Homo sapiens_hsa051310.96294823
52Viral carcinogenesis_Homo sapiens_hsa052030.96052880
53Basal transcription factors_Homo sapiens_hsa030220.95891381
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94954375
55Salmonella infection_Homo sapiens_hsa051320.94635908
56Rheumatoid arthritis_Homo sapiens_hsa053230.92397515
57Base excision repair_Homo sapiens_hsa034100.91022085
58Tuberculosis_Homo sapiens_hsa051520.90817402
59Malaria_Homo sapiens_hsa051440.88615183
60Sulfur relay system_Homo sapiens_hsa041220.86706732
61Pertussis_Homo sapiens_hsa051330.86504109
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.84936626
63Ribosome_Homo sapiens_hsa030100.83879441
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82643602
65Purine metabolism_Homo sapiens_hsa002300.82353662
66Pancreatic cancer_Homo sapiens_hsa052120.82073844
67RNA transport_Homo sapiens_hsa030130.77089302
68Hepatitis C_Homo sapiens_hsa051600.75476187
69Spliceosome_Homo sapiens_hsa030400.74358829
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71505698
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.71301959
72Small cell lung cancer_Homo sapiens_hsa052220.70869868
73Caffeine metabolism_Homo sapiens_hsa002320.68491591
74Mismatch repair_Homo sapiens_hsa034300.65941217
75Fanconi anemia pathway_Homo sapiens_hsa034600.65508951
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.65021198
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.64510906
78HIF-1 signaling pathway_Homo sapiens_hsa040660.62851884
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62291522
80VEGF signaling pathway_Homo sapiens_hsa043700.61631482
81Systemic lupus erythematosus_Homo sapiens_hsa053220.60378982
82Sulfur metabolism_Homo sapiens_hsa009200.59756949
83Regulation of autophagy_Homo sapiens_hsa041400.59679927
84p53 signaling pathway_Homo sapiens_hsa041150.59055281
85Huntingtons disease_Homo sapiens_hsa050160.55787837
86African trypanosomiasis_Homo sapiens_hsa051430.55482153
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.54735196
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54605149
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52030394
90Colorectal cancer_Homo sapiens_hsa052100.50428441
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49107973
92Alzheimers disease_Homo sapiens_hsa050100.48703575
93MicroRNAs in cancer_Homo sapiens_hsa052060.48170994
94RNA degradation_Homo sapiens_hsa030180.48129970
95mRNA surveillance pathway_Homo sapiens_hsa030150.47442913
96mTOR signaling pathway_Homo sapiens_hsa041500.45432867
97MAPK signaling pathway_Homo sapiens_hsa040100.44408807
98Staphylococcus aureus infection_Homo sapiens_hsa051500.44106391
99Proteasome_Homo sapiens_hsa030500.43549186
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43097221
101Non-small cell lung cancer_Homo sapiens_hsa052230.42135719
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41830798
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.40752993
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39473882
105Cell cycle_Homo sapiens_hsa041100.38581006
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38515215
107Linoleic acid metabolism_Homo sapiens_hsa005910.38293173
108Platelet activation_Homo sapiens_hsa046110.37580047
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36224969
110Homologous recombination_Homo sapiens_hsa034400.35627542
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34914476
112Renal cell carcinoma_Homo sapiens_hsa052110.33383248
113Insulin resistance_Homo sapiens_hsa049310.32022847
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31687047
115Prostate cancer_Homo sapiens_hsa052150.30805428
116Thyroid cancer_Homo sapiens_hsa052160.30267807
117Nucleotide excision repair_Homo sapiens_hsa034200.29746273
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29412686
119Phototransduction_Homo sapiens_hsa047440.27770740
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26519595
121Fructose and mannose metabolism_Homo sapiens_hsa000510.22313487
122Notch signaling pathway_Homo sapiens_hsa043300.21694323
123Propanoate metabolism_Homo sapiens_hsa006400.20530484
124Non-homologous end-joining_Homo sapiens_hsa034500.20004582
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.19210090
126Pyrimidine metabolism_Homo sapiens_hsa002400.18144041
127Endocytosis_Homo sapiens_hsa041440.17175745
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16809382
129Amoebiasis_Homo sapiens_hsa051460.16449514
130Pentose phosphate pathway_Homo sapiens_hsa000300.13981022
131Peroxisome_Homo sapiens_hsa041460.13866361
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10945096
133ABC transporters_Homo sapiens_hsa020100.10483480
134Folate biosynthesis_Homo sapiens_hsa007900.10243242
135Biosynthesis of amino acids_Homo sapiens_hsa012300.09914064
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.07418637

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