LTA4H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.19158303
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.10005271
3negative regulation of cell killing (GO:0031342)5.10005271
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.09391510
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.09391510
6modulation by symbiont of host immune response (GO:0052553)5.09391510
7positive regulation by symbiont of host defense response (GO:0052509)5.09391510
8modulation by symbiont of host defense response (GO:0052031)5.09391510
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.09391510
10disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.04447639
11killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.04447639
12detection of other organism (GO:0098543)5.02852860
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01113698
14negative regulation of phagocytosis (GO:0050765)4.94569929
15defense response to fungus (GO:0050832)4.89206159
16DNA unwinding involved in DNA replication (GO:0006268)4.85856822
17DNA strand elongation involved in DNA replication (GO:0006271)4.68504268
18detection of bacterium (GO:0016045)4.67729836
19response to fungus (GO:0009620)4.52624701
20DNA strand elongation (GO:0022616)4.48861702
21telomere maintenance via semi-conservative replication (GO:0032201)4.47378952
22negative regulation of interleukin-12 production (GO:0032695)4.36042789
23detection of molecule of bacterial origin (GO:0032490)4.34541060
24neutrophil mediated immunity (GO:0002446)4.34361697
25detection of external biotic stimulus (GO:0098581)4.31768723
26leukocyte aggregation (GO:0070486)4.26012938
27macrophage activation involved in immune response (GO:0002281)4.05056198
28neutrophil activation (GO:0042119)4.03270065
29pentose-phosphate shunt (GO:0006098)4.00634158
30regulation of gamma-delta T cell activation (GO:0046643)3.96345986
31protein localization to kinetochore (GO:0034501)3.94380116
32immunoglobulin mediated immune response (GO:0016064)3.94121015
33telomere maintenance via recombination (GO:0000722)3.94042205
34detection of biotic stimulus (GO:0009595)3.92981757
35disruption of cells of other organism (GO:0044364)3.92946127
36killing of cells of other organism (GO:0031640)3.92946127
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.85887092
38DNA replication initiation (GO:0006270)3.84972937
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.83160083
40response to host immune response (GO:0052572)3.82603654
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82603654
42viral transcription (GO:0019083)3.81144607
43positive regulation of mast cell activation (GO:0033005)3.77398442
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.77146598
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77146598
46negative regulation of growth of symbiont in host (GO:0044130)3.76667170
47negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.76667170
48modulation of growth of symbiont involved in interaction with host (GO:0044144)3.76667170
49regulation of growth of symbiont in host (GO:0044126)3.76667170
50translational termination (GO:0006415)3.71488979
51mitotic recombination (GO:0006312)3.70337482
52granulocyte activation (GO:0036230)3.70112280
53microglial cell activation (GO:0001774)3.63673380
54regulation of mast cell degranulation (GO:0043304)3.63494979
55NADPH regeneration (GO:0006740)3.61288424
56myeloid cell activation involved in immune response (GO:0002275)3.58933137
57B cell mediated immunity (GO:0019724)3.56140966
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54561606
59DNA deamination (GO:0045006)3.53242062
60response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.51141260
61response to host (GO:0075136)3.51141260
62response to host defenses (GO:0052200)3.51141260
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.51022359
64positive regulation of mast cell degranulation (GO:0043306)3.51022359
65regulation of gamma-delta T cell differentiation (GO:0045586)3.50534155
66cotranslational protein targeting to membrane (GO:0006613)3.45996742
67translational elongation (GO:0006414)3.44266309
68protein targeting to ER (GO:0045047)3.43587544
69regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43250742
70myeloid leukocyte mediated immunity (GO:0002444)3.39961205
71positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.32804686
72respiratory burst (GO:0045730)3.32708990
73negative regulation of lymphocyte mediated immunity (GO:0002707)3.32224962
74protein localization to chromosome, centromeric region (GO:0071459)3.31421298
75regulation of leukocyte degranulation (GO:0043300)3.31231885
76macrophage activation (GO:0042116)3.30451528
77telomere maintenance via telomere lengthening (GO:0010833)3.30146598
78regulation of mast cell activation involved in immune response (GO:0033006)3.29437072
79regulation of interferon-beta biosynthetic process (GO:0045357)3.28802827
80regulation of B cell differentiation (GO:0045577)3.27576886
81production of molecular mediator involved in inflammatory response (GO:0002532)3.27318187
82IMP metabolic process (GO:0046040)3.25905059
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25771729
84protein localization to endoplasmic reticulum (GO:0070972)3.24627205
85DNA replication checkpoint (GO:0000076)3.23858884
86regulation of mast cell activation (GO:0033003)3.23772315
87IMP biosynthetic process (GO:0006188)3.23319423
88nucleobase biosynthetic process (GO:0046112)3.20719290
89ribosomal small subunit biogenesis (GO:0042274)3.20590226
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.20416937
91positive regulation of cellular amide metabolic process (GO:0034250)3.18165082
92antigen processing and presentation of endogenous antigen (GO:0019883)3.15765209
93leukocyte degranulation (GO:0043299)3.12985163
94B cell receptor signaling pathway (GO:0050853)3.08748999
95positive regulation of leukocyte degranulation (GO:0043302)3.07765401
96formation of translation preinitiation complex (GO:0001731)3.07046299
97negative regulation of T cell mediated immunity (GO:0002710)3.05477721
98maturation of SSU-rRNA (GO:0030490)3.05004277
99sequestering of metal ion (GO:0051238)3.03276203
100mitotic chromosome condensation (GO:0007076)3.03212985
101nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00460744
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99558574
103response to muramyl dipeptide (GO:0032495)2.97286733
104positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96985312
105translational initiation (GO:0006413)2.96185245
106cellular protein complex disassembly (GO:0043624)2.95235781
107cellular response to zinc ion (GO:0071294)2.93873850
108negative regulation of leukocyte mediated immunity (GO:0002704)2.91708503
109viral life cycle (GO:0019058)2.91273732
110cell wall macromolecule catabolic process (GO:0016998)2.90576745
111pinocytosis (GO:0006907)2.89528291
112leukocyte mediated cytotoxicity (GO:0001909)2.86827519
113mitotic nuclear envelope disassembly (GO:0007077)2.86661947
114CENP-A containing nucleosome assembly (GO:0034080)2.85660151
115DNA topological change (GO:0006265)2.85128018
116regulation of tolerance induction (GO:0002643)2.84980643
117leukocyte migration involved in inflammatory response (GO:0002523)2.84292964
118negative regulation of interleukin-17 production (GO:0032700)2.82641508
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.79483428
120regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79292823
121regulation of protein heterodimerization activity (GO:0043497)2.77492001
122neutrophil chemotaxis (GO:0030593)2.77397352
123nucleobase-containing small molecule interconversion (GO:0015949)2.77078601
124positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76686218
125neutrophil activation involved in immune response (GO:0002283)2.75730738
126DNA duplex unwinding (GO:0032508)2.75033904
1273-UTR-mediated mRNA stabilization (GO:0070935)2.74346383
128positive thymic T cell selection (GO:0045059)2.73872630
129myeloid leukocyte activation (GO:0002274)2.72475534
130kinetochore organization (GO:0051383)2.72110887
131actin nucleation (GO:0045010)2.71876989
132chromatin remodeling at centromere (GO:0031055)2.71487333
133defense response to protozoan (GO:0042832)2.71133320
134protein complex disassembly (GO:0043241)2.70533488
135neutrophil migration (GO:1990266)2.70476489
136DNA geometric change (GO:0032392)2.70319638
137mitotic sister chromatid segregation (GO:0000070)2.70045252
138positive regulation of gamma-delta T cell activation (GO:0046645)2.69546193
139telomere maintenance (GO:0000723)2.69371799
140amino sugar catabolic process (GO:0046348)2.68939564
141glycosphingolipid catabolic process (GO:0046479)2.68832031
142regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68239815
143positive regulation of interferon-alpha production (GO:0032727)2.68227701
144telomere organization (GO:0032200)2.67625903
145folic acid-containing compound biosynthetic process (GO:0009396)2.67612023
146cellular extravasation (GO:0045123)2.66714533
147macrophage differentiation (GO:0030225)2.66325660
148interferon-gamma-mediated signaling pathway (GO:0060333)2.66172451
149response to peptidoglycan (GO:0032494)2.64781678
150regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64232021
151translesion synthesis (GO:0019985)2.63768694
152negative regulation of RNA splicing (GO:0033119)2.61812166
153regulation of interleukin-17 production (GO:0032660)2.61674204
154attachment of spindle microtubules to kinetochore (GO:0008608)2.61622199
155regulation of B cell receptor signaling pathway (GO:0050855)2.61405584
156glucose catabolic process (GO:0006007)2.61044289
157purine nucleobase biosynthetic process (GO:0009113)2.60929887
158positive regulation of B cell differentiation (GO:0045579)2.60861488
159nuclear envelope disassembly (GO:0051081)2.60251887
160membrane disassembly (GO:0030397)2.60251887
161oligosaccharide catabolic process (GO:0009313)2.59729671
162sister chromatid segregation (GO:0000819)2.59551853
163antigen processing and presentation via MHC class Ib (GO:0002475)2.58292626
164regulation of regulated secretory pathway (GO:1903305)2.58121309
165histone-serine phosphorylation (GO:0035404)2.56651006
166regulation of superoxide anion generation (GO:0032928)2.56213495
167positive regulation of toll-like receptor signaling pathway (GO:0034123)2.55767483
168negative regulation of innate immune response (GO:0045824)2.55451462
169regulation of spindle organization (GO:0090224)2.55389497
170mast cell activation (GO:0045576)2.54465321
171positive regulation of lamellipodium assembly (GO:0010592)2.52238763
172macromolecular complex disassembly (GO:0032984)2.51863426
173DNA replication-independent nucleosome assembly (GO:0006336)2.51209073
174DNA replication-independent nucleosome organization (GO:0034724)2.51209073
175lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50841895
176positive regulation of antigen processing and presentation (GO:0002579)2.50089401
177negative thymic T cell selection (GO:0045060)2.49769913
178regulation of T cell tolerance induction (GO:0002664)2.49336276
179dendritic cell migration (GO:0036336)2.47886370
180regulation of antigen processing and presentation (GO:0002577)2.47857554
181cellular response to thyroid hormone stimulus (GO:0097067)2.47104385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.35125484
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75181245
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.65972436
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19002543
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.04838715
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.88082620
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63644870
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57161903
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52361739
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51356916
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47077232
12VDR_21846776_ChIP-Seq_THP-1_Human2.44669777
13MYC_22102868_ChIP-Seq_BL_Human2.32121244
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26848369
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23119913
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15582351
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.14458050
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.11550338
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08122348
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06861572
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02418294
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98169019
23* SPI1_23547873_ChIP-Seq_NB4_Human1.97075924
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95142473
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93896533
26SCL_19346495_ChIP-Seq_HPC-7_Human1.90571065
27* ETS1_20019798_ChIP-Seq_JURKAT_Human1.86993066
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86094676
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85855842
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84716797
31XRN2_22483619_ChIP-Seq_HELA_Human1.84591730
32* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83125511
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82935283
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82790252
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.82698809
36* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80147537
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.79433973
38VDR_23849224_ChIP-Seq_CD4+_Human1.78224957
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75129578
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.74924635
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.74711082
42* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73457102
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73341376
44CIITA_25753668_ChIP-Seq_RAJI_Human1.72748282
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71409219
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63878214
47RUNX_20019798_ChIP-Seq_JUKART_Human1.61476388
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61412126
49AR_21909140_ChIP-Seq_LNCAP_Human1.61032268
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60304503
51VDR_24763502_ChIP-Seq_THP-1_Human1.60100906
52MYB_26560356_Chip-Seq_TH2_Human1.58186559
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51430360
54* PU_27001747_Chip-Seq_BMDM_Mouse1.51357112
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50688718
56DCP1A_22483619_ChIP-Seq_HELA_Human1.49890579
57UTX_26944678_Chip-Seq_JUKART_Human1.47815012
58MAF_26560356_Chip-Seq_TH1_Human1.47508600
59* RUNX1_22412390_ChIP-Seq_EML_Mouse1.46085868
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43052103
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42976924
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.42706826
63GABP_19822575_ChIP-Seq_HepG2_Human1.42491452
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39571705
65ELK1_19687146_ChIP-ChIP_HELA_Human1.37371950
66* VDR_24787735_ChIP-Seq_THP-1_Human1.37129283
67* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35997075
68MYB_26560356_Chip-Seq_TH1_Human1.35829995
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35779851
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35127470
71* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34367912
72* GATA3_27048872_Chip-Seq_THYMUS_Human1.31654701
73* TTF2_22483619_ChIP-Seq_HELA_Human1.29718415
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28763543
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27620215
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25294739
77* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24537120
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23198711
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23027351
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20377032
81TFEB_21752829_ChIP-Seq_HELA_Human1.19562037
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17923489
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17540282
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.16576297
85* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16268739
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15734162
87* GATA3_26560356_Chip-Seq_TH2_Human1.14470428
88* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12642093
89GATA1_22025678_ChIP-Seq_K562_Human1.12168986
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10401663
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10075292
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09683854
93* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08969561
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.08910332
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08180116
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07363303
97* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06264161
98* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05834792
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.04833316
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03870463
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03644167
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03540165
103KDM5A_27292631_Chip-Seq_BREAST_Human1.02698809
104TCF7_22412390_ChIP-Seq_EML_Mouse1.02621478
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01983339
106* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01741174
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01566100
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01221995
109* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00701450
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98791557
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97944640
112FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97130620
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97007290
114* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96719548
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95373906
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94485161
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94146822
118MAF_26560356_Chip-Seq_TH2_Human0.93035670
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92566582
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91379561
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91379561
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91379561
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90193275
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89838845
125* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89633092
126SPI1_23127762_ChIP-Seq_K562_Human0.88724605
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87191797
128* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81255380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.62021619
2MP0003693_abnormal_embryo_hatching3.45052165
3MP0010094_abnormal_chromosome_stability3.13277813
4MP0003436_decreased_susceptibility_to2.84611639
5MP0009785_altered_susceptibility_to2.71515662
6MP0001835_abnormal_antigen_presentation2.69741585
7MP0003111_abnormal_nucleus_morphology2.61667167
8MP0008260_abnormal_autophagy2.57742898
9MP0004957_abnormal_blastocyst_morpholog2.54717907
10MP0003077_abnormal_cell_cycle2.51516163
11MP0008057_abnormal_DNA_replication2.42846221
12MP0003303_peritoneal_inflammation2.42479663
13MP0006082_CNS_inflammation2.38948965
14MP0000490_abnormal_crypts_of2.36004036
15MP0003763_abnormal_thymus_physiology2.35360824
16MP0004808_abnormal_hematopoietic_stem2.30062186
17MP0006054_spinal_hemorrhage2.25528203
18MP0002419_abnormal_innate_immunity2.22238598
19MP0005464_abnormal_platelet_physiology2.19864947
20MP0005025_abnormal_response_to2.18220330
21MP0002398_abnormal_bone_marrow2.12357458
22MP0005671_abnormal_response_to2.10752722
23MP0003828_pulmonary_edema2.10000564
24MP0002420_abnormal_adaptive_immunity2.05371923
25MP0001819_abnormal_immune_cell2.02810941
26MP0002166_altered_tumor_susceptibility2.01169018
27MP0000685_abnormal_immune_system1.99078452
28MP0009333_abnormal_splenocyte_physiolog1.94785270
29MP0000465_gastrointestinal_hemorrhage1.94256668
30MP0008007_abnormal_cellular_replicative1.90861400
31MP0005174_abnormal_tail_pigmentation1.90142443
32MP0002452_abnormal_antigen_presenting1.88488693
33MP0001545_abnormal_hematopoietic_system1.87071545
34MP0005397_hematopoietic_system_phenotyp1.87071545
35MP0001800_abnormal_humoral_immune1.86623739
36MP0002722_abnormal_immune_system1.84110297
37MP0005000_abnormal_immune_tolerance1.83675310
38MP0000716_abnormal_immune_system1.81882825
39MP0003806_abnormal_nucleotide_metabolis1.77886972
40MP0002429_abnormal_blood_cell1.73980305
41MP0000689_abnormal_spleen_morphology1.73095684
42MP0002723_abnormal_immune_serum1.72666420
43MP0003183_abnormal_peptide_metabolism1.71784247
44MP0002405_respiratory_system_inflammati1.71508053
45MP0010352_gastrointestinal_tract_polyps1.68895989
46MP0010155_abnormal_intestine_physiology1.68834009
47MP0003172_abnormal_lysosome_physiology1.67270314
48MP0010307_abnormal_tumor_latency1.65727877
49MP0000858_altered_metastatic_potential1.64978287
50MP0000703_abnormal_thymus_morphology1.63125448
51MP0008058_abnormal_DNA_repair1.62236547
52MP0003724_increased_susceptibility_to1.57994146
53MP0001853_heart_inflammation1.57722569
54MP0002006_tumorigenesis1.53198675
55* MP0002148_abnormal_hypersensitivity_rea1.49553712
56MP0002019_abnormal_tumor_incidence1.49210591
57MP0004883_abnormal_blood_vessel1.48439203
58MP0001873_stomach_inflammation1.47765019
59MP0005075_abnormal_melanosome_morpholog1.41030124
60* MP0001845_abnormal_inflammatory_respons1.35289421
61MP0003300_gastrointestinal_ulcer1.34291641
62MP0003866_abnormal_defecation1.31990512
63MP0001533_abnormal_skeleton_physiology1.29979754
64MP0002095_abnormal_skin_pigmentation1.29898591
65MP0005387_immune_system_phenotype1.26641961
66MP0001790_abnormal_immune_system1.26641961
67MP0009278_abnormal_bone_marrow1.23680862
68MP0000350_abnormal_cell_proliferation1.22689161
69MP0000015_abnormal_ear_pigmentation1.22670174
70MP0002998_abnormal_bone_remodeling1.20273664
71MP0000604_amyloidosis1.19549755
72MP0000343_altered_response_to1.14721322
73MP0005310_abnormal_salivary_gland1.14220072
74MP0001730_embryonic_growth_arrest1.13163930
75MP0009764_decreased_sensitivity_to1.11712699
76MP0000313_abnormal_cell_death1.11382600
77MP0008932_abnormal_embryonic_tissue1.11100300
78MP0005164_abnormal_response_to1.05601635
79MP0000569_abnormal_digit_pigmentation1.04636920
80MP0005451_abnormal_body_composition1.03527528
81MP0003690_abnormal_glial_cell1.01170398
82MP0002009_preneoplasia1.00331783
83MP0005058_abnormal_lysosome_morphology0.99438870
84MP0005023_abnormal_wound_healing0.96899535
85MP0003123_paternal_imprinting0.94639048
86MP0003221_abnormal_cardiomyocyte_apopto0.94079092
87MP0001663_abnormal_digestive_system0.93290958
88MP0008469_abnormal_protein_level0.93252946
89MP0003186_abnormal_redox_activity0.92854880
90MP0003075_altered_response_to0.92000059
91MP0003566_abnormal_cell_adhesion0.91225372
92MP0001851_eye_inflammation0.89074662
93MP0002132_abnormal_respiratory_system0.88110014
94MP0002080_prenatal_lethality0.87197948
95MP0004947_skin_inflammation0.85838808
96MP0003656_abnormal_erythrocyte_physiolo0.85663199
97MP0000371_diluted_coat_color0.85183538
98MP0003191_abnormal_cellular_cholesterol0.85153544
99MP0004381_abnormal_hair_follicle0.84611546
100MP0004264_abnormal_extraembryonic_tissu0.84192576
101MP0009763_increased_sensitivity_to0.83606312
102MP0002877_abnormal_melanocyte_morpholog0.81565825
103MP0003448_altered_tumor_morphology0.81307770
104MP0003943_abnormal_hepatobiliary_system0.78625363
105MP0004782_abnormal_surfactant_physiolog0.77952654
106MP0010234_abnormal_vibrissa_follicle0.77043704
107MP0003567_abnormal_fetal_cardiomyocyte0.76485866
108MP0002933_joint_inflammation0.76248898
109MP0005388_respiratory_system_phenotype0.76131284
110MP0002133_abnormal_respiratory_system0.76131284
111MP0005166_decreased_susceptibility_to0.75839143
112MP0000477_abnormal_intestine_morphology0.74895759
113MP0001697_abnormal_embryo_size0.74729386
114MP0003786_premature_aging0.74445276
115MP0000358_abnormal_cell_content/0.74281127
116MP0002277_abnormal_respiratory_mucosa0.74276260
117MP0002089_abnormal_postnatal_growth/wei0.74165717
118MP0008873_increased_physiological_sensi0.68638511
119MP0005076_abnormal_cell_differentiation0.68359852
120MP0009840_abnormal_foam_cell0.67991114
121MP0003984_embryonic_growth_retardation0.67328698
122MP0009765_abnormal_xenobiotic_induced0.67031505
123MP0000249_abnormal_blood_vessel0.65407495
124MP0002086_abnormal_extraembryonic_tissu0.65194077
125MP0002088_abnormal_embryonic_growth/wei0.63805033
126MP0002254_reproductive_system_inflammat0.63772267
127MP0003795_abnormal_bone_structure0.63481544
128MP0008004_abnormal_stomach_pH0.59445925
129MP0005319_abnormal_enzyme/_coenzyme0.58913601

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.59360914
2Abnormality of glycolipid metabolism (HP:0010969)4.80028987
3Abnormality of liposaccharide metabolism (HP:0010968)4.80028987
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.80028987
5Eczematoid dermatitis (HP:0000976)4.51370225
6Recurrent abscess formation (HP:0002722)4.41863416
7Reticulocytopenia (HP:0001896)4.03661629
8Retrobulbar optic neuritis (HP:0100654)3.91723546
9Optic neuritis (HP:0100653)3.91723546
10Recurrent bacterial skin infections (HP:0005406)3.83389235
11Increased cerebral lipofuscin (HP:0011813)3.76681425
12Elevated erythrocyte sedimentation rate (HP:0003565)3.72738498
13IgM deficiency (HP:0002850)3.71773516
14Stomatitis (HP:0010280)3.66062015
15Obstructive lung disease (HP:0006536)3.64603342
16Chronic obstructive pulmonary disease (HP:0006510)3.64603342
17Abnormality of cells of the erythroid lineage (HP:0012130)3.61172475
18Abnormal number of erythroid precursors (HP:0012131)3.60329401
19B lymphocytopenia (HP:0010976)3.53422590
20Abnormality of B cell number (HP:0010975)3.53422590
21Aplastic anemia (HP:0001915)3.48451006
22Myositis (HP:0100614)3.32490723
23Abnormality of T cell physiology (HP:0011840)3.09542029
24Meningitis (HP:0001287)3.06680506
25Recurrent fungal infections (HP:0002841)3.06164942
26Disinhibition (HP:0000734)3.05115218
27Recurrent viral infections (HP:0004429)3.04608729
28Eosinophilia (HP:0001880)3.00108341
29Granulocytopenia (HP:0001913)2.99845113
30Petechiae (HP:0000967)2.99755608
31Gastrointestinal infarctions (HP:0005244)2.99271500
32Keratoconjunctivitis sicca (HP:0001097)2.98147410
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.91804295
34Periodontitis (HP:0000704)2.90800309
35Recurrent gram-negative bacterial infections (HP:0005420)2.89139938
36Encephalitis (HP:0002383)2.85512022
37Reduced antithrombin III activity (HP:0001976)2.81422768
38Abnormality of the prostate (HP:0008775)2.78536726
39Mediastinal lymphadenopathy (HP:0100721)2.77593164
40Loss of speech (HP:0002371)2.76124690
41Abnormality of T cells (HP:0002843)2.75958225
42Cellulitis (HP:0100658)2.75032800
43Keratoconjunctivitis (HP:0001096)2.74493470
44Chest pain (HP:0100749)2.72590716
45Chronic otitis media (HP:0000389)2.69091542
46Myocardial infarction (HP:0001658)2.67076031
47Poikiloderma (HP:0001029)2.67012462
48Hepatosplenomegaly (HP:0001433)2.58640086
49Inflammation of the large intestine (HP:0002037)2.55891532
50Amyloidosis (HP:0011034)2.54313716
51Gingival bleeding (HP:0000225)2.53506390
52Type I transferrin isoform profile (HP:0003642)2.52121400
53Pustule (HP:0200039)2.50958158
54Arterial thrombosis (HP:0004420)2.49562825
55Recurrent skin infections (HP:0001581)2.49083170
56Gastrointestinal inflammation (HP:0004386)2.46582104
57Leukocytosis (HP:0001974)2.46406235
58Anorexia (HP:0002039)2.46350250
59Cutaneous melanoma (HP:0012056)2.45560589
60Myelodysplasia (HP:0002863)2.43702204
61Papilledema (HP:0001085)2.43090118
62Hypochromic microcytic anemia (HP:0004840)2.42412072
63Pulmonary infiltrates (HP:0002113)2.40035424
64Abnormality of eosinophils (HP:0001879)2.36078377
65Abnormality of macrophages (HP:0004311)2.34990551
66Interstitial pulmonary disease (HP:0006530)2.33030328
67Epistaxis (HP:0000421)2.29794645
68Chromsome breakage (HP:0040012)2.26462805
69Spontaneous hematomas (HP:0007420)2.23278469
70Viral hepatitis (HP:0006562)2.23121077
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.22363666
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.21395601
7311 pairs of ribs (HP:0000878)2.21224630
74Recurrent bronchitis (HP:0002837)2.19416565
75Hemoptysis (HP:0002105)2.19221752
76Premature loss of primary teeth (HP:0006323)2.18788266
77Lymphopenia (HP:0001888)2.18220245
78Neutropenia (HP:0001875)2.17537675
79Panhypogammaglobulinemia (HP:0003139)2.16814779
80Pallor (HP:0000980)2.15711407
81Abnormal protein glycosylation (HP:0012346)2.14827901
82Abnormal glycosylation (HP:0012345)2.14827901
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14827901
84Abnormal protein N-linked glycosylation (HP:0012347)2.14827901
85Entropion (HP:0000621)2.12911439
86Amaurosis fugax (HP:0100576)2.11833630
87Lymphoma (HP:0002665)2.11424626
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.11268013
89Agnosia (HP:0010524)2.10053115
90Skin ulcer (HP:0200042)2.09626289
91Macrocytic anemia (HP:0001972)2.09573345
92Autoimmune thrombocytopenia (HP:0001973)2.09030561
93Oral leukoplakia (HP:0002745)2.08812346
94Abnormal platelet volume (HP:0011876)2.08686931
95Pulmonary embolism (HP:0002204)2.08179694
96Abnormality of DNA repair (HP:0003254)2.07524883
97Abnormal platelet function (HP:0011869)2.07408218
98Impaired platelet aggregation (HP:0003540)2.07408218
99Pulmonary fibrosis (HP:0002206)2.07263950
100Prostate neoplasm (HP:0100787)2.07130065
101Bone marrow hypocellularity (HP:0005528)2.05451511
102Osteomyelitis (HP:0002754)2.05157640
103Abnormality of the pleura (HP:0002103)2.05092401
104Prolonged bleeding time (HP:0003010)2.05073271
105Colitis (HP:0002583)2.02648176
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01555468
107Abnormality of the anterior horn cell (HP:0006802)2.00716127
108Degeneration of anterior horn cells (HP:0002398)2.00716127
109T lymphocytopenia (HP:0005403)2.00400913
110Vasculitis (HP:0002633)1.99436281
111Increased IgM level (HP:0003496)1.99419463
112Orchitis (HP:0100796)1.99279552
113Abnormality of chromosome stability (HP:0003220)1.98925438
114Gingivitis (HP:0000230)1.98629628
115Dysostosis multiplex (HP:0000943)1.98253449
116Gangrene (HP:0100758)1.97829022
117Combined immunodeficiency (HP:0005387)1.96500870
118Birth length less than 3rd percentile (HP:0003561)1.94707146
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94699419
120Hypergammaglobulinemia (HP:0010702)1.92852344
121Pancytopenia (HP:0001876)1.91391258
122Subacute progressive viral hepatitis (HP:0006572)1.91195647
123Severe combined immunodeficiency (HP:0004430)1.91090458
124Urticaria (HP:0001025)1.91073483
125Systemic lupus erythematosus (HP:0002725)1.90314946
126Basal cell carcinoma (HP:0002671)1.88688097
127Recurrent cutaneous fungal infections (HP:0011370)1.88505834
128Chronic mucocutaneous candidiasis (HP:0002728)1.88505834
129Ureteral stenosis (HP:0000071)1.87872136
130Premature graying of hair (HP:0002216)1.87423071
131Abnormality of T cell number (HP:0011839)1.87314646
132Acute myeloid leukemia (HP:0004808)1.86874527
133Sepsis (HP:0100806)1.86414557
134Glomerulopathy (HP:0100820)1.86199107
135Aplasia/Hypoplasia of the thymus (HP:0010515)1.85590753
136High pitched voice (HP:0001620)1.85530613
137IgG deficiency (HP:0004315)1.85349053
138Recurrent pneumonia (HP:0006532)1.85086643
139Abnormality of the thoracic spine (HP:0100711)1.84895103
140Hematochezia (HP:0002573)1.83192697
141Vacuolated lymphocytes (HP:0001922)1.80568893
142Polyneuropathy (HP:0001271)1.79224088
143Increased serum ferritin (HP:0003281)1.79155277
144Fatigue (HP:0012378)1.76250586
145Episodic fever (HP:0001954)1.75213699
146Abnormality of iron homeostasis (HP:0011031)1.74962716
147Microcytic anemia (HP:0001935)1.74010492
148Thrombophlebitis (HP:0004418)1.73741091
149Agammaglobulinemia (HP:0004432)1.71401157
150Increased IgE level (HP:0003212)1.70950015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.60663654
2MAP4K12.90530836
3WEE12.88535505
4BUB12.83937023
5CDC72.75424848
6IRAK42.66891610
7FGR2.65727744
8EEF2K2.65594575
9TESK22.54993853
10PKN22.46920999
11STK162.24631582
12TESK12.09190196
13BMPR22.07029112
14CDK192.05500258
15EIF2AK31.97467989
16BTK1.89855598
17MAP3K131.88344987
18NEK21.77739483
19FLT31.68112751
20TEC1.68031900
21BLK1.64029900
22BRSK21.61698616
23ZAP701.61473855
24GRK61.58675777
25STK101.58028987
26ERN11.55347742
27MAP2K31.54095032
28TRIB31.52716852
29TGFBR11.48839270
30PIM21.48015490
31PRPF4B1.47452019
32KDR1.47319805
33RPS6KB21.46909342
34PASK1.44677231
35LRRK21.38486839
36EIF2AK11.37351844
37CLK11.37182893
38MAP3K101.37065194
39ACVR1B1.36476654
40VRK11.36298436
41PAK41.36081653
42YES11.35310086
43TXK1.35058741
44KIT1.32556101
45FES1.29646965
46MAP3K121.28621667
47TSSK61.26134749
48JAK11.18794498
49TAOK31.17855183
50ATR1.17349205
51JAK31.16199591
52SCYL21.16071593
53NME21.12591664
54SYK1.10476638
55SRPK11.10458204
56JAK21.10403039
57CDK71.09868543
58TYK21.09752828
59MAP3K81.09621672
60MST41.06558729
61MARK31.06057246
62MAP3K31.04853249
63TNK21.03015731
64CDK41.02758178
65LIMK10.99942213
66NEK10.99340188
67ITK0.98450466
68RPS6KA40.96389503
69PIM10.94973636
70AURKB0.94789824
71MAP3K110.93207765
72ILK0.92998659
73STK40.89584776
74CSF1R0.89349224
75PBK0.89003647
76BRSK10.87513067
77MAPKAPK30.87448210
78PLK10.85117426
79SMG10.84713227
80MKNK10.83459107
81MAP3K60.83251840
82CDK80.82253055
83IKBKB0.81832667
84TBK10.81448806
85NEK90.80210007
86TRPM70.79617527
87SIK30.77677607
88CCNB10.76622973
89ALK0.75869391
90TGFBR20.75312973
91LYN0.74780666
92TLK10.74731932
93MAP3K10.72786737
94STK240.71879532
95NUAK10.70288619
96LCK0.70136337
97IRAK10.68655809
98IRAK20.67739128
99KSR20.67392447
100PIK3CG0.66528177
101PDK20.66315135
102HCK0.65437209
103CSK0.65412831
104MAPK40.64877222
105TTK0.63388259
106MAPK110.61609706
107VRK20.60774526
108CDK60.58634578
109RPS6KA60.58277155
110RPS6KC10.56770325
111RPS6KL10.56770325
112PDK10.56491431
113EPHB10.54368286
114MYLK0.53887739
115PLK40.53835803
116TAF10.53405522
117DAPK10.52271550
118FYN0.52042617
119NLK0.50876413
120IKBKE0.50826547
121BRD40.50440367
122PTK60.50124231
123MAP2K60.48688933
124RAF10.48199219
125EGFR0.47629433
126BCKDK0.47420083
127MAP3K140.46752891
128MATK0.46477426
129MAP3K50.46350707
130TTN0.45409406
131PDPK10.45405587
132DYRK30.44309827
133CHEK10.41992373
134PAK10.41486057
135EIF2AK20.40218615
136NEK60.40153340
137CHEK20.38654313
138ZAK0.37422577
139MAP3K20.36892212
140MAPKAPK20.36290553
141CSNK2A10.35626552
142PRKCQ0.35522472
143AURKA0.34980055
144MAPK70.34126760
145FGFR30.34051098
146MAP2K20.29977561

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15635237
2Mismatch repair_Homo sapiens_hsa034303.65743058
3Ribosome_Homo sapiens_hsa030103.15747051
4Staphylococcus aureus infection_Homo sapiens_hsa051503.14804635
5Base excision repair_Homo sapiens_hsa034102.92068058
6Allograft rejection_Homo sapiens_hsa053302.60520880
7Graft-versus-host disease_Homo sapiens_hsa053322.50569771
8Homologous recombination_Homo sapiens_hsa034402.49488997
9Autoimmune thyroid disease_Homo sapiens_hsa053202.39664149
10Spliceosome_Homo sapiens_hsa030402.38788656
11Nucleotide excision repair_Homo sapiens_hsa034202.23882618
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17940140
13Cell cycle_Homo sapiens_hsa041102.10181173
14Non-homologous end-joining_Homo sapiens_hsa034502.08722436
15Lysosome_Homo sapiens_hsa041422.08624920
16Proteasome_Homo sapiens_hsa030502.02096290
17One carbon pool by folate_Homo sapiens_hsa006701.97737707
18Pentose phosphate pathway_Homo sapiens_hsa000301.86210734
19Type I diabetes mellitus_Homo sapiens_hsa049401.83773649
20Primary immunodeficiency_Homo sapiens_hsa053401.80514065
21Leishmaniasis_Homo sapiens_hsa051401.79348093
22RNA transport_Homo sapiens_hsa030131.74572330
23Pyrimidine metabolism_Homo sapiens_hsa002401.71602231
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69889543
25Rheumatoid arthritis_Homo sapiens_hsa053231.67786232
26Malaria_Homo sapiens_hsa051441.63710051
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59653097
28Antigen processing and presentation_Homo sapiens_hsa046121.58762250
29Fanconi anemia pathway_Homo sapiens_hsa034601.49937574
30N-Glycan biosynthesis_Homo sapiens_hsa005101.39501365
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39412666
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29224146
33Legionellosis_Homo sapiens_hsa051341.26074553
34Protein export_Homo sapiens_hsa030601.25653487
35RNA polymerase_Homo sapiens_hsa030201.24943938
36Herpes simplex infection_Homo sapiens_hsa051681.20966247
37Other glycan degradation_Homo sapiens_hsa005111.20752043
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20138345
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19032313
40RNA degradation_Homo sapiens_hsa030181.18841425
41p53 signaling pathway_Homo sapiens_hsa041151.18105794
42Galactose metabolism_Homo sapiens_hsa000521.16006621
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14792321
44Measles_Homo sapiens_hsa051621.14720247
45Chemokine signaling pathway_Homo sapiens_hsa040621.12322571
46Shigellosis_Homo sapiens_hsa051311.10274815
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.09504528
48Renin-angiotensin system_Homo sapiens_hsa046141.02670492
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.96818579
50Epstein-Barr virus infection_Homo sapiens_hsa051690.95426381
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94809668
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91850228
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.90099612
54Osteoclast differentiation_Homo sapiens_hsa043800.89800566
55B cell receptor signaling pathway_Homo sapiens_hsa046620.89083280
56Apoptosis_Homo sapiens_hsa042100.88429184
57Hematopoietic cell lineage_Homo sapiens_hsa046400.87645313
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.86979273
59Viral carcinogenesis_Homo sapiens_hsa052030.86563896
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83805779
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83463140
62Systemic lupus erythematosus_Homo sapiens_hsa053220.82170380
63Biosynthesis of amino acids_Homo sapiens_hsa012300.82012696
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79757671
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.77668432
66Hepatitis B_Homo sapiens_hsa051610.77523567
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77189118
68Glutathione metabolism_Homo sapiens_hsa004800.76785497
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76465300
70Purine metabolism_Homo sapiens_hsa002300.76217105
71TNF signaling pathway_Homo sapiens_hsa046680.74822788
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74713495
73Viral myocarditis_Homo sapiens_hsa054160.74377742
74African trypanosomiasis_Homo sapiens_hsa051430.74364549
75mRNA surveillance pathway_Homo sapiens_hsa030150.73969819
76Carbon metabolism_Homo sapiens_hsa012000.73491384
77HTLV-I infection_Homo sapiens_hsa051660.71524330
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71271055
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70908092
80Thyroid cancer_Homo sapiens_hsa052160.69629984
81Pertussis_Homo sapiens_hsa051330.69286501
82Fructose and mannose metabolism_Homo sapiens_hsa000510.68928369
83Chronic myeloid leukemia_Homo sapiens_hsa052200.68797396
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68625437
85Toxoplasmosis_Homo sapiens_hsa051450.68353812
86Influenza A_Homo sapiens_hsa051640.68330352
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66561232
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66028981
89Platelet activation_Homo sapiens_hsa046110.65854029
90Regulation of autophagy_Homo sapiens_hsa041400.64497616
91Acute myeloid leukemia_Homo sapiens_hsa052210.64422167
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61727510
93Tuberculosis_Homo sapiens_hsa051520.61671285
94Hepatitis C_Homo sapiens_hsa051600.60998168
95Basal transcription factors_Homo sapiens_hsa030220.60807387
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.60052848
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57692440
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56947966
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.54474810
100T cell receptor signaling pathway_Homo sapiens_hsa046600.53820829
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53801989
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53478362
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53013226
104Asthma_Homo sapiens_hsa053100.52618355
105Small cell lung cancer_Homo sapiens_hsa052220.52165529
106Pancreatic cancer_Homo sapiens_hsa052120.50756193
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50487518
108Salmonella infection_Homo sapiens_hsa051320.49517172
109Phagosome_Homo sapiens_hsa041450.47559157
110Sulfur relay system_Homo sapiens_hsa041220.46432796
111Renal cell carcinoma_Homo sapiens_hsa052110.45547570
112HIF-1 signaling pathway_Homo sapiens_hsa040660.45463486
113Non-small cell lung cancer_Homo sapiens_hsa052230.45187015
114Starch and sucrose metabolism_Homo sapiens_hsa005000.44251346
115Selenocompound metabolism_Homo sapiens_hsa004500.43572931
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.42972031
117Caffeine metabolism_Homo sapiens_hsa002320.42614399
118Colorectal cancer_Homo sapiens_hsa052100.41550700
119Collecting duct acid secretion_Homo sapiens_hsa049660.41169851
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.39869849
121Amoebiasis_Homo sapiens_hsa051460.39169323
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38461811
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.37572948
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36262758
125Endocytosis_Homo sapiens_hsa041440.35995221
126Notch signaling pathway_Homo sapiens_hsa043300.29740091
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29140053
128FoxO signaling pathway_Homo sapiens_hsa040680.26539767
129Endometrial cancer_Homo sapiens_hsa052130.25643080
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.24379650

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