LTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.49729097
2cytidine metabolic process (GO:0046087)8.49729097
3cytidine catabolic process (GO:0006216)8.49729097
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.76889834
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.68411956
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.68411956
7positive regulation of gamma-delta T cell activation (GO:0046645)7.33092302
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.32140586
9antigen processing and presentation of endogenous antigen (GO:0019883)7.25912236
10DNA deamination (GO:0045006)6.64149498
11regulation of gamma-delta T cell differentiation (GO:0045586)6.05616126
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.00824701
13positive thymic T cell selection (GO:0045059)5.97256830
14response to interleukin-15 (GO:0070672)5.90435808
15negative T cell selection (GO:0043383)5.86066836
16negative thymic T cell selection (GO:0045060)5.77079995
17cellular response to interleukin-15 (GO:0071350)5.51828741
18regulation of gamma-delta T cell activation (GO:0046643)5.49117506
19positive T cell selection (GO:0043368)5.22471766
20thymic T cell selection (GO:0045061)5.10283511
21regulation of B cell receptor signaling pathway (GO:0050855)5.07803243
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.03482497
23negative regulation of cell killing (GO:0031342)5.03482497
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.96737868
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88672118
26T cell selection (GO:0045058)4.82253117
27T cell migration (GO:0072678)4.66160796
28regulation of isotype switching to IgG isotypes (GO:0048302)4.65739425
29leukocyte aggregation (GO:0070486)4.63962164
30positive regulation of interleukin-8 secretion (GO:2000484)4.63174627
31interferon-gamma production (GO:0032609)4.58896256
32regulation of activation of Janus kinase activity (GO:0010533)4.58202124
33negative regulation by host of viral transcription (GO:0043922)4.58000304
34B cell receptor signaling pathway (GO:0050853)4.54477833
35antigen processing and presentation via MHC class Ib (GO:0002475)4.43990539
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.40671838
37regulation of B cell differentiation (GO:0045577)4.30406562
38positive regulation of T cell mediated cytotoxicity (GO:0001916)4.29695867
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.29129467
40regulation of regulatory T cell differentiation (GO:0045589)4.26645816
41T cell receptor signaling pathway (GO:0050852)4.24365659
42antigen receptor-mediated signaling pathway (GO:0050851)4.22959550
43regulation of T cell mediated cytotoxicity (GO:0001914)4.21101879
44eosinophil chemotaxis (GO:0048245)4.15993448
45regulation of lymphocyte chemotaxis (GO:1901623)4.15343731
46regulation of leukocyte mediated cytotoxicity (GO:0001910)4.13301238
47ribosomal small subunit assembly (GO:0000028)4.04288852
48positive regulation of calcium-mediated signaling (GO:0050850)4.00619727
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.00206315
50regulation of alpha-beta T cell proliferation (GO:0046640)3.96917349
51positive regulation of defense response to virus by host (GO:0002230)3.96606299
52dendritic cell chemotaxis (GO:0002407)3.95649247
53T cell costimulation (GO:0031295)3.92984877
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.91046440
55negative regulation of T cell apoptotic process (GO:0070233)3.90809070
56regulation of T cell tolerance induction (GO:0002664)3.90075601
57lymphocyte costimulation (GO:0031294)3.89722939
58negative regulation of viral genome replication (GO:0045071)3.88421750
59NIK/NF-kappaB signaling (GO:0038061)3.87441397
60positive regulation of cell killing (GO:0031343)3.85815944
61viral transcription (GO:0019083)3.85267360
62mature B cell differentiation (GO:0002335)3.84299743
63positive regulation of B cell differentiation (GO:0045579)3.82539226
64T cell homeostasis (GO:0043029)3.81837700
65regulation of cell killing (GO:0031341)3.79571968
66eosinophil migration (GO:0072677)3.75802172
67regulation of T cell receptor signaling pathway (GO:0050856)3.71216606
68positive regulation of interleukin-2 production (GO:0032743)3.69576374
69pyrimidine nucleoside catabolic process (GO:0046135)3.66954439
70positive regulation of lymphocyte migration (GO:2000403)3.65782945
71translational termination (GO:0006415)3.63844967
72regulation of chronic inflammatory response (GO:0002676)3.63352193
73positive regulation of humoral immune response (GO:0002922)3.63337384
74cellular defense response (GO:0006968)3.58544936
75lymphocyte chemotaxis (GO:0048247)3.57813018
76negative regulation of erythrocyte differentiation (GO:0045647)3.53706977
77mature B cell differentiation involved in immune response (GO:0002313)3.53517601
78JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.51569402
79regulation of type I interferon-mediated signaling pathway (GO:0060338)3.49814426
80mast cell activation (GO:0045576)3.49083220
81positive regulation of isotype switching (GO:0045830)3.46804066
82response to type I interferon (GO:0034340)3.45173267
83macrophage chemotaxis (GO:0048246)3.44228218
84positive regulation of tolerance induction (GO:0002645)3.43644028
85regulation of response to interferon-gamma (GO:0060330)3.43360594
86granulocyte activation (GO:0036230)3.43269558
87chemokine-mediated signaling pathway (GO:0070098)3.42925357
88tolerance induction (GO:0002507)3.41765063
89cellular response to type I interferon (GO:0071357)3.39537018
90type I interferon signaling pathway (GO:0060337)3.39537018
91lymphocyte homeostasis (GO:0002260)3.38171054
92regulation of T cell chemotaxis (GO:0010819)3.36905482
93positive regulation of T cell chemotaxis (GO:0010820)3.36905482
94positive regulation of alpha-beta T cell proliferation (GO:0046641)3.36414293
95regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.34321253
96lymphocyte migration (GO:0072676)3.31387779
97actin nucleation (GO:0045010)3.29756368
98regulation of interleukin-8 secretion (GO:2000482)3.29395826
99dendritic cell migration (GO:0036336)3.27670867
100interferon-gamma-mediated signaling pathway (GO:0060333)3.22687239
101positive regulation of B cell mediated immunity (GO:0002714)3.22272379
102positive regulation of immunoglobulin mediated immune response (GO:0002891)3.22272379
103regulation of B cell mediated immunity (GO:0002712)3.20510348
104regulation of interleukin-2 biosynthetic process (GO:0045076)3.20446887
105leukocyte degranulation (GO:0043299)3.19724994
106regulation of immunoglobulin mediated immune response (GO:0002889)3.17367315
107negative regulation of B cell proliferation (GO:0030889)3.17365522
108leukocyte homeostasis (GO:0001776)3.16627030
109regulation of isotype switching (GO:0045191)3.15395783
110immune response-activating cell surface receptor signaling pathway (GO:0002429)3.15376273
111natural killer cell activation (GO:0030101)3.14763146
112activated T cell proliferation (GO:0050798)3.13480073
113positive regulation of immunoglobulin production (GO:0002639)3.13433213
114defense response to protozoan (GO:0042832)3.12542257
115translational elongation (GO:0006414)3.12467292
116myeloid dendritic cell activation (GO:0001773)3.11792201
117positive regulation of T cell mediated immunity (GO:0002711)3.11737088
118response to protozoan (GO:0001562)3.10606964
119regulation of natural killer cell mediated immunity (GO:0002715)3.09141631
120regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.09141631
121Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08198991
122negative regulation of T cell receptor signaling pathway (GO:0050860)3.07170213
123cellular response to zinc ion (GO:0071294)3.06404014
124ribosomal small subunit biogenesis (GO:0042274)3.06313337
125regulation of tolerance induction (GO:0002643)3.05554928
126regulation of lymphocyte migration (GO:2000401)3.04813305
127positive regulation of natural killer cell mediated immunity (GO:0002717)3.04525969
128positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.04525969
129positive regulation of monocyte chemotaxis (GO:0090026)3.04307159
130positive regulation of DNA recombination (GO:0045911)3.03346036
131T cell differentiation (GO:0030217)3.02313454
132monocyte chemotaxis (GO:0002548)3.02178460
133negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.01633682
134negative regulation of lymphocyte mediated immunity (GO:0002707)3.01613081
135alpha-beta T cell activation (GO:0046631)3.00680080
136neutrophil activation (GO:0042119)2.99731709
137* regulation of interleukin-12 biosynthetic process (GO:0045075)2.98714486
138positive regulation of macrophage differentiation (GO:0045651)2.98595019
139Peyers patch development (GO:0048541)2.98105243
140mucosal-associated lymphoid tissue development (GO:0048537)2.98105243
141mast cell activation involved in immune response (GO:0002279)2.97522160
142mast cell degranulation (GO:0043303)2.97522160
143immunoglobulin mediated immune response (GO:0016064)2.94360834
144nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93543251
145positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.93142652
146SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92445422
147regulation of immunoglobulin production (GO:0002637)2.92429834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.56235385
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.83974074
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.72180657
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.03718808
5MYC_22102868_ChIP-Seq_BL_Human3.96670626
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27197149
7* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.13665580
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.10244330
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.08281000
10RUNX_20019798_ChIP-Seq_JUKART_Human3.05998878
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93093945
12MYB_26560356_Chip-Seq_TH2_Human2.90969391
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89712959
14VDR_21846776_ChIP-Seq_THP-1_Human2.87248433
15MAF_26560356_Chip-Seq_TH1_Human2.86198728
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.75642783
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70565323
18MYB_26560356_Chip-Seq_TH1_Human2.61317792
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.58647297
20UTX_26944678_Chip-Seq_JUKART_Human2.55505568
21SCL_19346495_ChIP-Seq_HPC-7_Human2.54762413
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53700171
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.43240964
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22235888
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14198709
26E2F7_22180533_ChIP-Seq_HELA_Human2.12381142
27SPI1_23547873_ChIP-Seq_NB4_Human2.11854194
28* TCF7_22412390_ChIP-Seq_EML_Mouse2.10569925
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.04501287
30VDR_24763502_ChIP-Seq_THP-1_Human2.02348463
31MAF_26560356_Chip-Seq_TH2_Human2.01740575
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01114596
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00706029
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98434122
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97962282
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97431747
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.97226730
38* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93174408
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93041570
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90966038
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89384115
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84530332
43GATA3_27048872_Chip-Seq_THYMUS_Human1.75692573
44* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71429599
45CIITA_25753668_ChIP-Seq_RAJI_Human1.71015829
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68470707
47* KDM2B_26808549_Chip-Seq_DND41_Human1.68123116
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67344855
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61911770
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60802516
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58247739
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53786001
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49892579
54SPI1_23127762_ChIP-Seq_K562_Human1.46536243
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40366290
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.40319090
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39079873
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38586538
59* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38110670
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38096167
61* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36884782
62VDR_23849224_ChIP-Seq_CD4+_Human1.31372320
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30733628
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26625286
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24697081
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24355943
67* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22869742
68FOXP3_21729870_ChIP-Seq_TREG_Human1.19560654
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19263006
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18612370
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15798940
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14959696
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14570967
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.13481875
75PU_27001747_Chip-Seq_BMDM_Mouse1.10560213
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10483616
77RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10171760
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10025421
79GATA3_26560356_Chip-Seq_TH2_Human1.09722058
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04907547
81BCOR_27268052_Chip-Seq_Bcells_Human1.04244120
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03727438
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.01837652
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.01653909
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00827813
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.99965319
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97961644
88XRN2_22483619_ChIP-Seq_HELA_Human0.95075002
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94569826
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94425142
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93520030
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92843554
93NCOR1_26117541_ChIP-Seq_K562_Human0.92809655
94GATA3_26560356_Chip-Seq_TH1_Human0.92247793
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91884928
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91702704
97LXR_22292898_ChIP-Seq_THP-1_Human0.90430939
98BCL6_27268052_Chip-Seq_Bcells_Human0.89858802
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89760134
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88939416
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88822477
102MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86174648
103TAF2_19829295_ChIP-Seq_ESCs_Human0.85823615
104NANOG_20526341_ChIP-Seq_ESCs_Human0.85709037
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85510272
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84902555
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.83823990
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81500433
109VDR_24787735_ChIP-Seq_THP-1_Human0.80349091
110P300_27268052_Chip-Seq_Bcells_Human0.80281354
111SA1_27219007_Chip-Seq_Bcells_Human0.80231424
112GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80012232
113CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79796116
114SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79654716
115GATA1_22025678_ChIP-Seq_K562_Human0.79442771
116GABP_17652178_ChIP-ChIP_JURKAT_Human0.77739231
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76045983
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.75912996
119SPI1_20517297_ChIP-Seq_HL60_Human0.75505770
120SMRT_27268052_Chip-Seq_Bcells_Human0.75396380
121ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74464593
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.74318914
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72263043
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.71877974
125* CTCF_20526341_ChIP-Seq_ESCs_Human0.71256283
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70724390
127TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.70647827
128E2F1_20622854_ChIP-Seq_HELA_Human0.70483126
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68581768
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68542238
131STAT1_20625510_ChIP-Seq_HELA_Human0.67143765
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66300174
133RAC3_21632823_ChIP-Seq_H3396_Human0.64918013
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.63495820
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.63398871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.59980892
2MP0000685_abnormal_immune_system4.36166025
3MP0001835_abnormal_antigen_presentation4.29816629
4MP0005671_abnormal_response_to3.95591969
5* MP0001800_abnormal_humoral_immune3.63911887
6MP0001790_abnormal_immune_system3.62356956
7MP0005387_immune_system_phenotype3.62356956
8* MP0002452_abnormal_antigen_presenting2.95904066
9MP0005000_abnormal_immune_tolerance2.95588629
10* MP0002420_abnormal_adaptive_immunity2.94349470
11* MP0002723_abnormal_immune_serum2.94191723
12* MP0001819_abnormal_immune_cell2.89368344
13* MP0002398_abnormal_bone_marrow2.89205245
14* MP0009785_altered_susceptibility_to2.76027201
15MP0002396_abnormal_hematopoietic_system2.70116827
16MP0002166_altered_tumor_susceptibility2.67243633
17* MP0005025_abnormal_response_to2.56298910
18* MP0000716_abnormal_immune_system2.55786102
19MP0003436_decreased_susceptibility_to2.55638620
20MP0001873_stomach_inflammation2.51431365
21* MP0000689_abnormal_spleen_morphology2.39908795
22MP0009333_abnormal_splenocyte_physiolog2.39233081
23MP0002405_respiratory_system_inflammati2.36111077
24MP0003866_abnormal_defecation2.35466712
25* MP0002722_abnormal_immune_system2.33327369
26MP0003303_peritoneal_inflammation2.32130400
27MP0000703_abnormal_thymus_morphology2.26535766
28MP0003300_gastrointestinal_ulcer2.15939098
29* MP0002429_abnormal_blood_cell2.12479435
30* MP0010155_abnormal_intestine_physiology2.09963693
31MP0002006_tumorigenesis2.07516265
32MP0002148_abnormal_hypersensitivity_rea2.03680613
33MP0005464_abnormal_platelet_physiology2.02826271
34MP0002419_abnormal_innate_immunity2.02190103
35MP0004510_myositis1.99227216
36MP0004808_abnormal_hematopoietic_stem1.91936715
37MP0004947_skin_inflammation1.90081453
38MP0001853_heart_inflammation1.82074020
39MP0006082_CNS_inflammation1.78757251
40* MP0001845_abnormal_inflammatory_respons1.75422146
41MP0002933_joint_inflammation1.73672848
42MP0003724_increased_susceptibility_to1.66607714
43MP0000465_gastrointestinal_hemorrhage1.52455554
44MP0005397_hematopoietic_system_phenotyp1.43900539
45MP0001545_abnormal_hematopoietic_system1.43900539
46MP0000569_abnormal_digit_pigmentation1.41258378
47MP0005075_abnormal_melanosome_morpholog1.39358372
48MP0000490_abnormal_crypts_of1.38833207
49MP0005174_abnormal_tail_pigmentation1.34218081
50MP0002163_abnormal_gland_morphology1.28879500
51MP0005310_abnormal_salivary_gland1.28045889
52MP0002876_abnormal_thyroid_physiology1.22706611
53MP0002277_abnormal_respiratory_mucosa1.19022252
54MP0008469_abnormal_protein_level1.18772286
55MP0009278_abnormal_bone_marrow1.18060372
56MP0000858_altered_metastatic_potential1.12410916
57MP0002019_abnormal_tumor_incidence1.06086222
58MP0001533_abnormal_skeleton_physiology1.00384311
59MP0003878_abnormal_ear_physiology0.99713309
60MP0005377_hearing/vestibular/ear_phenot0.99713309
61MP0004145_abnormal_muscle_electrophysio0.94467862
62MP0002132_abnormal_respiratory_system0.83237166
63MP0002138_abnormal_hepatobiliary_system0.82829679
64MP0002095_abnormal_skin_pigmentation0.79832411
65MP0003448_altered_tumor_morphology0.78406645
66MP0010352_gastrointestinal_tract_polyps0.78285558
67MP0001851_eye_inflammation0.76681215
68MP0001348_abnormal_lacrimal_gland0.74981560
69MP0005390_skeleton_phenotype0.74062763
70MP0009764_decreased_sensitivity_to0.73666390
71MP0002102_abnormal_ear_morphology0.73612903
72MP0003077_abnormal_cell_cycle0.73394946
73MP0004381_abnormal_hair_follicle0.72558633
74MP0003279_aneurysm0.71924577
75MP0001663_abnormal_digestive_system0.71155392
76MP0005023_abnormal_wound_healing0.70949985
77MP0003786_premature_aging0.70404388
78MP0008961_abnormal_basal_metabolism0.70010877
79MP0000604_amyloidosis0.65983999
80MP0002998_abnormal_bone_remodeling0.64907653
81MP0008057_abnormal_DNA_replication0.64732881
82MP0001919_abnormal_reproductive_system0.64179552
83MP0000015_abnormal_ear_pigmentation0.63626907
84MP0003075_altered_response_to0.63151508
85MP0001501_abnormal_sleep_pattern0.62911925
86* MP0000477_abnormal_intestine_morphology0.61700480
87MP0005379_endocrine/exocrine_gland_phen0.61623346
88MP0003045_fibrosis0.61365865
89MP0001765_abnormal_ion_homeostasis0.60960282
90MP0001986_abnormal_taste_sensitivity0.59774359
91MP0002136_abnormal_kidney_physiology0.57407195
92MP0003693_abnormal_embryo_hatching0.57354076
93MP0008872_abnormal_physiological_respon0.56732499
94* MP0009763_increased_sensitivity_to0.56346366
95MP0000313_abnormal_cell_death0.56142108
96MP0005166_decreased_susceptibility_to0.55977068
97MP0002009_preneoplasia0.55841406
98MP0003191_abnormal_cellular_cholesterol0.55578955
99MP0003011_delayed_dark_adaptation0.54963531
100MP0000609_abnormal_liver_physiology0.52963333
101MP0003172_abnormal_lysosome_physiology0.52515148
102MP0004742_abnormal_vestibular_system0.51494751
103MP0008007_abnormal_cellular_replicative0.51254114
104MP0004957_abnormal_blastocyst_morpholog0.48101590
105MP0004130_abnormal_muscle_cell0.48071714
106MP0003091_abnormal_cell_migration0.47865381
107MP0003795_abnormal_bone_structure0.47563295
108MP0003453_abnormal_keratinocyte_physiol0.47366883
109MP0003943_abnormal_hepatobiliary_system0.45304004
110MP0001191_abnormal_skin_condition0.45131340
111* MP0009765_abnormal_xenobiotic_induced0.44794385
112MP0008877_abnormal_DNA_methylation0.44728528
113MP0003879_abnormal_hair_cell0.44604927
114MP0003828_pulmonary_edema0.43762819
115MP0003183_abnormal_peptide_metabolism0.43002914
116MP0000249_abnormal_blood_vessel0.42951683
117MP0009643_abnormal_urine_homeostasis0.42407370
118MP0000920_abnormal_myelination0.41919485
119MP0008058_abnormal_DNA_repair0.41565242
120MP0001968_abnormal_touch/_nociception0.39920387
121MP0008874_decreased_physiological_sensi0.39820761
122MP0002693_abnormal_pancreas_physiology0.39733506
123MP0006054_spinal_hemorrhage0.39549263
124MP0005165_increased_susceptibility_to0.38646712
125MP0008873_increased_physiological_sensi0.37959982
126MP0000343_altered_response_to0.37071323
127MP0002928_abnormal_bile_duct0.36589968
128MP0002083_premature_death0.36290340

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)5.98955659
2Chronic otitis media (HP:0000389)5.83354011
3T lymphocytopenia (HP:0005403)5.27358788
4IgM deficiency (HP:0002850)5.24196289
5Elevated erythrocyte sedimentation rate (HP:0003565)5.24195726
6Panhypogammaglobulinemia (HP:0003139)5.15876012
7Abnormal delayed hypersensitivity skin test (HP:0002963)5.15706524
8Nasal polyposis (HP:0100582)5.07268892
9Abnormality of T cell number (HP:0011839)5.05036897
10Agammaglobulinemia (HP:0004432)5.02238282
11Abnormality of T cells (HP:0002843)4.67457262
12Recurrent viral infections (HP:0004429)4.64376441
13Abnormality of the nasal mucosa (HP:0000433)4.52266288
14Recurrent fungal infections (HP:0002841)4.45686351
15Recurrent cutaneous fungal infections (HP:0011370)4.20485280
16Chronic mucocutaneous candidiasis (HP:0002728)4.20485280
17Lymphopenia (HP:0001888)4.13208399
18Inflammation of the large intestine (HP:0002037)4.09094253
19Gastrointestinal inflammation (HP:0004386)4.08711013
20Myositis (HP:0100614)4.02459478
21Thrombocytosis (HP:0001894)4.00893886
22Stomatitis (HP:0010280)3.99063656
23Recurrent sinusitis (HP:0011108)3.96131430
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.95058685
25Abnormality of T cell physiology (HP:0011840)3.92627582
26Colitis (HP:0002583)3.80920495
27Gastrointestinal stroma tumor (HP:0100723)3.77847491
28Chronic sinusitis (HP:0011109)3.77100126
29IgG deficiency (HP:0004315)3.75211326
30Abnormality of the prostate (HP:0008775)3.71443785
31Eczematoid dermatitis (HP:0000976)3.70058807
32Meningitis (HP:0001287)3.67410680
33Bronchitis (HP:0012387)3.49761994
34Chronic diarrhea (HP:0002028)3.47903923
35Recurrent abscess formation (HP:0002722)3.47797430
36Pustule (HP:0200039)3.42881894
37Abnormality of macrophages (HP:0004311)3.42105855
38Severe combined immunodeficiency (HP:0004430)3.39622036
39Combined immunodeficiency (HP:0005387)3.35181722
40Aplastic anemia (HP:0001915)3.34582249
41Abnormality of the fingertips (HP:0001211)3.33499344
42Cellulitis (HP:0100658)3.28097185
43Vasculitis (HP:0002633)3.20754629
44Abnormality of B cell number (HP:0010975)3.14460029
45B lymphocytopenia (HP:0010976)3.14460029
46Papilloma (HP:0012740)3.09703057
47Verrucae (HP:0200043)3.09703057
48Recurrent skin infections (HP:0001581)3.08689675
49Emphysema (HP:0002097)3.08445110
50Gangrene (HP:0100758)3.04066722
51Spontaneous hematomas (HP:0007420)3.00224142
52Thyroiditis (HP:0100646)2.91348812
53IgA deficiency (HP:0002720)2.91342917
54Recurrent bacterial skin infections (HP:0005406)2.86481910
55Prolonged bleeding time (HP:0003010)2.86108736
56Hypoproteinemia (HP:0003075)2.82491966
57Increased IgE level (HP:0003212)2.81876570
58Pulmonary fibrosis (HP:0002206)2.80044505
59Encephalitis (HP:0002383)2.76886136
60Mediastinal lymphadenopathy (HP:0100721)2.75305337
61Autoimmune thrombocytopenia (HP:0001973)2.74092090
62Keratoconjunctivitis (HP:0001096)2.73140805
63Lymphoma (HP:0002665)2.73061459
64Keratoconjunctivitis sicca (HP:0001097)2.70514313
65Abnormality of eosinophils (HP:0001879)2.68102638
66Abnormality of the pleura (HP:0002103)2.67024882
67Pulmonary embolism (HP:0002204)2.65513100
68Basal cell carcinoma (HP:0002671)2.62132369
69Interstitial pulmonary disease (HP:0006530)2.55160808
70Ureteral stenosis (HP:0000071)2.55142806
71Joint swelling (HP:0001386)2.54259391
72Epistaxis (HP:0000421)2.53699185
73Leukocytosis (HP:0001974)2.47230110
74Granulocytopenia (HP:0001913)2.45086523
75Eosinophilia (HP:0001880)2.44723438
76Hemoptysis (HP:0002105)2.43679991
77Autoimmune hemolytic anemia (HP:0001890)2.41551769
78Recurrent otitis media (HP:0000403)2.40790493
79Obstructive lung disease (HP:0006536)2.39229495
80Chronic obstructive pulmonary disease (HP:0006510)2.39229495
81Retrobulbar optic neuritis (HP:0100654)2.34393588
82Optic neuritis (HP:0100653)2.34393588
83Petechiae (HP:0000967)2.34353394
84Chest pain (HP:0100749)2.34039271
85Abnormality of cells of the erythroid lineage (HP:0012130)2.33437666
86Stomach cancer (HP:0012126)2.33395173
87Orchitis (HP:0100796)2.32328888
88Ureteral obstruction (HP:0006000)2.31350379
89Abnormality of the pericardium (HP:0001697)2.28805714
90Hypergammaglobulinemia (HP:0010702)2.27842541
91Poikiloderma (HP:0001029)2.26001100
92Pulmonary infiltrates (HP:0002113)2.25074286
93Hypochromic anemia (HP:0001931)2.23673214
94Polyneuropathy (HP:0001271)2.21388592
95Cheilitis (HP:0100825)2.21367084
96Arterial thrombosis (HP:0004420)2.21201400
97Hemiplegia (HP:0002301)2.19418554
98Anorexia (HP:0002039)2.18480642
99Premature loss of primary teeth (HP:0006323)2.18161337
100Abnormality of male internal genitalia (HP:0000022)2.17787302
101Restrictive lung disease (HP:0002091)2.17382420
102Gingival bleeding (HP:0000225)2.15175167
103Hypoplasia of the thymus (HP:0000778)2.14765775
104Bronchiectasis (HP:0002110)2.14168934
105Increased density of long bones (HP:0006392)2.13075673
106Fatigue (HP:0012378)2.12179099
107Abnormal number of erythroid precursors (HP:0012131)2.11838124
108Glomerulopathy (HP:0100820)2.09483681
109Increased IgM level (HP:0003496)2.08077674
110Skin ulcer (HP:0200042)2.07897559
111Amaurosis fugax (HP:0100576)2.05682037
112Hepatosplenomegaly (HP:0001433)2.04854358
113Osteomyelitis (HP:0002754)2.04716553
114Hepatitis (HP:0012115)2.01845150
115Gastrointestinal infarctions (HP:0005244)2.01833854
116Skin rash (HP:0000988)1.97906499
117Renal cortical cysts (HP:0000803)1.97892957
118Entropion (HP:0000621)1.97025626
119Viral hepatitis (HP:0006562)1.96150804
120Impaired platelet aggregation (HP:0003540)1.94440981
121Abnormal platelet function (HP:0011869)1.94440981
122Congenital stationary night blindness (HP:0007642)1.93945593
123Periodontitis (HP:0000704)1.93250864
124Recurrent gram-negative bacterial infections (HP:0005420)1.92825903
125Microcytic anemia (HP:0001935)1.90690157
126Urticaria (HP:0001025)1.89642180
127Diplopia (HP:0000651)1.88523561
128Abnormality of binocular vision (HP:0011514)1.88523561
129Sepsis (HP:0100806)1.84799097
130Pancreatitis (HP:0001733)1.81825807
131Severe visual impairment (HP:0001141)1.81389883
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78238504
133Abnormal albumin level (HP:0012116)1.77624377
134Hypoalbuminemia (HP:0003073)1.77624377
135Arthralgia (HP:0002829)1.71127457
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71015466
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71015466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.19905921
2TXK3.55323704
3JAK33.09064594
4ZAP702.77331665
5TYK22.62196511
6GRK62.56235415
7IKBKE2.55680520
8FGFR42.53646729
9ITK2.38162723
10STK102.30729506
11KIT2.24881263
12EEF2K2.17599497
13NME22.16023920
14BTK2.13814921
15NLK2.00888943
16MAP3K132.00460332
17MAP3K141.97450942
18TEC1.96298158
19TBK11.94447014
20MAP3K101.92285808
21BCKDK1.89269212
22JAK11.81712436
23SYK1.77181059
24BLK1.72712106
25CSF1R1.69100817
26LCK1.68046609
27FGFR31.66461625
28LRRK21.55924771
29FLT31.54505435
30TLK11.54469718
31IKBKB1.53684769
32HCK1.39705290
33IRAK41.35997856
34SIK21.34947662
35TGFBR21.32239990
36CSK1.30794885
37PKN21.28995748
38MAP2K31.26245230
39GRK71.25205674
40MARK31.22776811
41MAP2K21.19911345
42PIK3CA1.19546643
43SIK31.14504037
44MST41.13012391
45ERN11.12163070
46CAMKK11.11471654
47RPS6KA41.10856205
48TGFBR11.08876602
49FES1.03666058
50CLK11.02188276
51MAP4K21.00555753
52LYN0.99865212
53KDR0.98932649
54PIM10.96628959
55PRKCH0.96054341
56MAPKAPK30.95723966
57CHUK0.92388906
58PRKCQ0.83235650
59MAP3K70.82230594
60TRIB30.80504681
61EPHB10.76778490
62CAMKK20.74999684
63TNK20.74356859
64JAK20.73134426
65RIPK40.70754943
66HIPK20.68918687
67GRK10.67601763
68SIK10.67080224
69IRAK30.65085735
70PRKD20.63383817
71EPHA30.61535821
72TNIK0.61088989
73TYRO30.60259353
74MATK0.59846785
75TAOK10.55179835
76RPS6KB20.54774350
77PDK10.54148036
78MARK20.54093377
79CDK40.53950035
80PASK0.52068051
81BMPR20.51913158
82ACVR1B0.49514813
83IGF1R0.49419759
84ZAK0.46929351
85MAP2K60.46833006
86ADRBK20.45574332
87MAPK110.45001593
88CDK190.44794636
89TESK20.44748880
90NUAK10.42559837
91ALK0.42537216
92RAF10.39853638
93IRAK10.37361929
94CDK120.36716214
95TAOK30.36711474
96TESK10.36138358
97FGR0.35645449
98PRKCD0.35350313
99WNK40.35124390
100OXSR10.34579858
101MAP3K110.34529281
102MAP3K120.33670808
103MELK0.33222266
104RPS6KA50.32946620
105PTK60.32335122
106DAPK20.32199975
107MAPK40.31676152
108MAPK120.30790598
109NEK20.30548741
110MAP3K80.29917558
111ADRBK10.29760652
112PRKCA0.27242723
113PIM20.26868347
114BRD40.26422937
115PIK3CG0.26279755
116CDK90.25906669
117CDC42BPA0.25304525
118INSR0.25301806
119FYN0.24812596
120ABL10.24628847
121MAPK30.24427007
122RPS6KA60.23412523
123INSRR0.22827995
124DAPK10.22738142
125MAPKAPK20.22283804
126STK40.20969913
127SRC0.20769232
128MAPK70.20763252
129MUSK0.20119274
130GRK50.19797445
131FRK0.19332290
132EIF2AK30.19212754
133EGFR0.17717227
134LIMK10.17098588
135PDPK10.15221277
136PINK10.14686518
137RET0.13798750
138PRKCB0.13462152

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.64417532
2B cell receptor signaling pathway_Homo sapiens_hsa046623.22066607
3T cell receptor signaling pathway_Homo sapiens_hsa046603.16958016
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.82285261
5* NF-kappa B signaling pathway_Homo sapiens_hsa040642.61774741
6Measles_Homo sapiens_hsa051622.61117824
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53078097
8Antigen processing and presentation_Homo sapiens_hsa046122.51645401
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.50256881
10Ribosome_Homo sapiens_hsa030102.38526561
11Hematopoietic cell lineage_Homo sapiens_hsa046402.34289905
12Leishmaniasis_Homo sapiens_hsa051402.24662514
13Osteoclast differentiation_Homo sapiens_hsa043802.18514019
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96741245
15* Rheumatoid arthritis_Homo sapiens_hsa053231.95295218
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.93796372
17Herpes simplex infection_Homo sapiens_hsa051681.78830293
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77646605
19Acute myeloid leukemia_Homo sapiens_hsa052211.67457013
20Allograft rejection_Homo sapiens_hsa053301.61951164
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60108978
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54260570
23Shigellosis_Homo sapiens_hsa051311.43054885
24Chemokine signaling pathway_Homo sapiens_hsa040621.41697224
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.38465698
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37647940
27Graft-versus-host disease_Homo sapiens_hsa053321.36985049
28Toxoplasmosis_Homo sapiens_hsa051451.36890239
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36395535
30Hepatitis B_Homo sapiens_hsa051611.32738185
31Influenza A_Homo sapiens_hsa051641.25725304
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25108716
33Viral myocarditis_Homo sapiens_hsa054161.22771242
34Platelet activation_Homo sapiens_hsa046111.20353951
35TNF signaling pathway_Homo sapiens_hsa046681.14589760
36Epstein-Barr virus infection_Homo sapiens_hsa051691.10835734
37Apoptosis_Homo sapiens_hsa042101.07298718
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05348191
39* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04752487
40HTLV-I infection_Homo sapiens_hsa051661.03663579
41Chronic myeloid leukemia_Homo sapiens_hsa052201.03215478
42Pancreatic cancer_Homo sapiens_hsa052121.02147012
43Base excision repair_Homo sapiens_hsa034101.01348546
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01057529
45Proteasome_Homo sapiens_hsa030501.00954618
46Prolactin signaling pathway_Homo sapiens_hsa049170.93474613
47Tuberculosis_Homo sapiens_hsa051520.92954320
48Hepatitis C_Homo sapiens_hsa051600.90336426
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89426826
50Legionellosis_Homo sapiens_hsa051340.88704966
51DNA replication_Homo sapiens_hsa030300.87643357
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.87113016
53VEGF signaling pathway_Homo sapiens_hsa043700.86257948
54Autoimmune thyroid disease_Homo sapiens_hsa053200.85732259
55Colorectal cancer_Homo sapiens_hsa052100.82925750
56Spliceosome_Homo sapiens_hsa030400.82673053
57Viral carcinogenesis_Homo sapiens_hsa052030.79699828
58Asthma_Homo sapiens_hsa053100.77816905
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76298491
60Linoleic acid metabolism_Homo sapiens_hsa005910.74341529
61Mismatch repair_Homo sapiens_hsa034300.73567792
62Malaria_Homo sapiens_hsa051440.73246750
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72746404
64Non-small cell lung cancer_Homo sapiens_hsa052230.72576802
65Pertussis_Homo sapiens_hsa051330.71905372
66p53 signaling pathway_Homo sapiens_hsa041150.71792682
67Salmonella infection_Homo sapiens_hsa051320.70082926
68Type I diabetes mellitus_Homo sapiens_hsa049400.67147937
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65318328
70Sulfur relay system_Homo sapiens_hsa041220.64771011
71Phototransduction_Homo sapiens_hsa047440.63374182
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60756424
73Notch signaling pathway_Homo sapiens_hsa043300.60457429
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60320119
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51570662
76Non-homologous end-joining_Homo sapiens_hsa034500.50252178
77RNA degradation_Homo sapiens_hsa030180.49355480
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49261900
79Small cell lung cancer_Homo sapiens_hsa052220.48782680
80Thyroid cancer_Homo sapiens_hsa052160.48684964
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48001256
82Caffeine metabolism_Homo sapiens_hsa002320.47042130
83African trypanosomiasis_Homo sapiens_hsa051430.46728208
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45750756
85Systemic lupus erythematosus_Homo sapiens_hsa053220.45604641
86Nitrogen metabolism_Homo sapiens_hsa009100.45547582
87Insulin resistance_Homo sapiens_hsa049310.45245610
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44646679
89Other glycan degradation_Homo sapiens_hsa005110.44243862
90Staphylococcus aureus infection_Homo sapiens_hsa051500.42881958
91FoxO signaling pathway_Homo sapiens_hsa040680.41476881
92MAPK signaling pathway_Homo sapiens_hsa040100.40973123
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.38957081
94Arachidonic acid metabolism_Homo sapiens_hsa005900.38820605
95Endocytosis_Homo sapiens_hsa041440.38712734
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38409965
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.38208780
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38019826
99mTOR signaling pathway_Homo sapiens_hsa041500.37512418
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35927747
101Nucleotide excision repair_Homo sapiens_hsa034200.35865248
102Inositol phosphate metabolism_Homo sapiens_hsa005620.34626813
103HIF-1 signaling pathway_Homo sapiens_hsa040660.32167412
104Lysosome_Homo sapiens_hsa041420.32063669
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32044602
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29520251
107Phagosome_Homo sapiens_hsa041450.29284346
108Pyrimidine metabolism_Homo sapiens_hsa002400.28419164
109Pathways in cancer_Homo sapiens_hsa052000.27820453
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26243531
111Rap1 signaling pathway_Homo sapiens_hsa040150.25970151
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25156415
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24308276
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24197692
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23767414
116Endometrial cancer_Homo sapiens_hsa052130.23503482
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23435481
118RNA polymerase_Homo sapiens_hsa030200.23178363
119Prion diseases_Homo sapiens_hsa050200.22425595
120Oxidative phosphorylation_Homo sapiens_hsa001900.20510307
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.19837090
122Regulation of autophagy_Homo sapiens_hsa041400.18544810
123Peroxisome_Homo sapiens_hsa041460.17445952
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.17314163
125ABC transporters_Homo sapiens_hsa020100.14436713
126Ether lipid metabolism_Homo sapiens_hsa005650.12343971
127Retinol metabolism_Homo sapiens_hsa008300.11840863
128Glycerolipid metabolism_Homo sapiens_hsa005610.08161886
129Olfactory transduction_Homo sapiens_hsa047400.08157648
130Ras signaling pathway_Homo sapiens_hsa040140.07239122
131Morphine addiction_Homo sapiens_hsa050320.05953096
132Parkinsons disease_Homo sapiens_hsa050120.05723682
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.03963275
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03777497
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.02022556
136Collecting duct acid secretion_Homo sapiens_hsa049660.00984270
137Sulfur metabolism_Homo sapiens_hsa009200.00090050

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