LTB4R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.88116309
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.88116309
3detection of other organism (GO:0098543)5.67783050
4detection of bacterium (GO:0016045)5.62890916
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61851704
6positive regulation of gamma-delta T cell activation (GO:0046645)5.56412629
7positive regulation by symbiont of host defense response (GO:0052509)5.51260096
8modulation by symbiont of host defense response (GO:0052031)5.51260096
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.51260096
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.51260096
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.51260096
12modulation by symbiont of host immune response (GO:0052553)5.51260096
13neutrophil activation involved in immune response (GO:0002283)5.22158746
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.19208249
15leukocyte aggregation (GO:0070486)5.13302808
16antigen processing and presentation of endogenous antigen (GO:0019883)5.11716625
17response to peptidoglycan (GO:0032494)4.95281641
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.71151809
19regulation of B cell receptor signaling pathway (GO:0050855)4.65043320
20macrophage activation involved in immune response (GO:0002281)4.62540074
21detection of external biotic stimulus (GO:0098581)4.61895770
22leukocyte migration involved in inflammatory response (GO:0002523)4.46562154
23cellular extravasation (GO:0045123)4.40579408
24regulation of gamma-delta T cell activation (GO:0046643)4.31915929
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.25532719
26neutrophil activation (GO:0042119)4.15959469
27detection of biotic stimulus (GO:0009595)4.08704180
28regulation of interferon-beta biosynthetic process (GO:0045357)4.03635686
29response to host immune response (GO:0052572)3.95216685
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.95216685
31regulation of gamma-delta T cell differentiation (GO:0045586)3.93096303
32detection of molecule of bacterial origin (GO:0032490)3.91320951
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90296909
34negative regulation of T cell mediated immunity (GO:0002710)3.86039984
35negative regulation of interleukin-12 production (GO:0032695)3.84074836
36response to interleukin-15 (GO:0070672)3.82060580
37response to muramyl dipeptide (GO:0032495)3.80503557
38negative regulation of erythrocyte differentiation (GO:0045647)3.78647978
39respiratory burst (GO:0045730)3.73502534
40regulation of mast cell degranulation (GO:0043304)3.71537123
41negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.71270920
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.71224634
43response to host (GO:0075136)3.71224634
44response to host defenses (GO:0052200)3.71224634
45immunoglobulin mediated immune response (GO:0016064)3.71166666
46granulocyte activation (GO:0036230)3.70726348
47negative regulation of leukocyte mediated immunity (GO:0002704)3.69031242
48microglial cell activation (GO:0001774)3.65891374
49myeloid cell activation involved in immune response (GO:0002275)3.61604479
50neutrophil mediated immunity (GO:0002446)3.50667972
51regulation of myeloid leukocyte mediated immunity (GO:0002886)3.49717776
52antigen processing and presentation via MHC class Ib (GO:0002475)3.49480020
53cellular response to interleukin-15 (GO:0071350)3.44137230
54negative thymic T cell selection (GO:0045060)3.43362638
55regulation of mast cell activation involved in immune response (GO:0033006)3.38560626
56macrophage activation (GO:0042116)3.38373830
57negative regulation of phagocytosis (GO:0050765)3.36619730
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35931112
59positive regulation of mast cell activation (GO:0033005)3.35324337
60regulation of leukocyte degranulation (GO:0043300)3.32499063
61positive thymic T cell selection (GO:0045059)3.31800360
62B cell receptor signaling pathway (GO:0050853)3.29328987
63negative T cell selection (GO:0043383)3.28622874
64regulation of B cell differentiation (GO:0045577)3.27473462
65negative regulation of interleukin-6 production (GO:0032715)3.27436436
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27023738
67regulation of mast cell activation (GO:0033003)3.26720401
68leukocyte degranulation (GO:0043299)3.25512967
69germinal center formation (GO:0002467)3.24995789
70response to type I interferon (GO:0034340)3.21723098
71tolerance induction (GO:0002507)3.21023699
72cellular response to type I interferon (GO:0071357)3.20289307
73type I interferon signaling pathway (GO:0060337)3.20289307
74positive regulation of B cell differentiation (GO:0045579)3.17912129
75negative regulation of innate immune response (GO:0045824)3.14312194
76negative regulation of T-helper cell differentiation (GO:0045623)3.09548540
77negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09548540
78production of molecular mediator involved in inflammatory response (GO:0002532)3.08046767
79regulation of tolerance induction (GO:0002643)3.08024588
80T cell selection (GO:0045058)2.97795225
81activated T cell proliferation (GO:0050798)2.96068549
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.95165274
83B cell mediated immunity (GO:0019724)2.93833205
84regulation of T cell tolerance induction (GO:0002664)2.93416751
85defense response to protozoan (GO:0042832)2.92954916
86negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.92772559
87positive regulation of interferon-alpha production (GO:0032727)2.90666465
88positive regulation of mast cell activation involved in immune response (GO:0033008)2.90186751
89positive regulation of mast cell degranulation (GO:0043306)2.90186751
90defense response to fungus (GO:0050832)2.88552331
91thymic T cell selection (GO:0045061)2.87804790
92myeloid leukocyte mediated immunity (GO:0002444)2.87771863
93positive regulation of granulocyte differentiation (GO:0030854)2.84873136
94regulation of regulated secretory pathway (GO:1903305)2.84219739
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83895348
96regulation of T cell mediated cytotoxicity (GO:0001914)2.83746174
97mast cell activation (GO:0045576)2.82887549
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81590732
99negative regulation of type 2 immune response (GO:0002829)2.80347119
100interferon-gamma-mediated signaling pathway (GO:0060333)2.80095707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.95720760
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43847005
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42636888
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.36412846
5VDR_21846776_ChIP-Seq_THP-1_Human3.35668832
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85879672
7* VDR_24763502_ChIP-Seq_THP-1_Human2.84934342
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.84672366
9MYC_22102868_ChIP-Seq_BL_Human2.74864411
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62794191
11SPI1_23547873_ChIP-Seq_NB4_Human2.59363455
12MAF_26560356_Chip-Seq_TH1_Human2.57941086
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.53850149
14SCL_19346495_ChIP-Seq_HPC-7_Human2.51401546
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49249556
16RUNX_20019798_ChIP-Seq_JUKART_Human2.48348694
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42601886
18RUNX1_22412390_ChIP-Seq_EML_Mouse2.38150090
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36772334
20* UTX_26944678_Chip-Seq_JUKART_Human2.31780529
21MYB_26560356_Chip-Seq_TH2_Human2.30195510
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28644690
23SPI1_23127762_ChIP-Seq_K562_Human2.26971756
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25128769
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24457006
26TCF7_22412390_ChIP-Seq_EML_Mouse2.23694232
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22690070
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22140302
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11383112
30MAF_26560356_Chip-Seq_TH2_Human2.10587247
31MYB_26560356_Chip-Seq_TH1_Human2.10348231
32KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09771793
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07156420
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05720251
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02940066
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.00650771
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93302784
38KDM2B_26808549_Chip-Seq_DND41_Human1.92803248
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87435252
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85317824
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.83695068
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74103517
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72309928
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.70998515
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.63769629
46* LXR_22292898_ChIP-Seq_THP-1_Human1.60654980
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58942008
48GATA3_27048872_Chip-Seq_THYMUS_Human1.58606727
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54623447
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48940650
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.48132842
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47967542
53BCL6_27268052_Chip-Seq_Bcells_Human1.47128078
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46108724
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44608022
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44042741
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43065327
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42863721
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42854497
60BCOR_27268052_Chip-Seq_Bcells_Human1.42452071
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42216820
62VDR_24787735_ChIP-Seq_THP-1_Human1.40429895
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38598320
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35133851
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32613281
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.29280285
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28414490
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28259897
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27940770
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27902419
71GATA1_19941826_ChIP-Seq_K562_Human1.25973320
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22570844
73GATA3_26560356_Chip-Seq_TH2_Human1.22507812
74P68_20966046_ChIP-Seq_HELA_Human1.22265664
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20771710
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19597004
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19213192
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19170587
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18365358
80PU_27001747_Chip-Seq_BMDM_Mouse1.17530729
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16406769
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15283291
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.14327929
84* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12915921
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11271471
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10431167
87NCOR1_26117541_ChIP-Seq_K562_Human1.10326481
88RACK7_27058665_Chip-Seq_MCF-7_Human1.09114647
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.05669491
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04022246
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01950762
92E2F1_20622854_ChIP-Seq_HELA_Human1.01851548
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01576671
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01143712
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96690151
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96300213
97GATA2_19941826_ChIP-Seq_K562_Human0.94744984
98SPI1_20517297_ChIP-Seq_HL60_Human0.94394838
99P300_27268052_Chip-Seq_Bcells_Human0.94258551
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93789665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.40008676
2MP0003724_increased_susceptibility_to4.35733608
3MP0001835_abnormal_antigen_presentation3.41855520
4MP0002419_abnormal_innate_immunity3.06504221
5MP0000685_abnormal_immune_system2.97523850
6MP0003303_peritoneal_inflammation2.92871900
7MP0005671_abnormal_response_to2.87735916
8MP0005025_abnormal_response_to2.85235926
9MP0001800_abnormal_humoral_immune2.82131489
10MP0005000_abnormal_immune_tolerance2.72839001
11MP0009785_altered_susceptibility_to2.66315446
12MP0001790_abnormal_immune_system2.63556240
13MP0005387_immune_system_phenotype2.63556240
14MP0003763_abnormal_thymus_physiology2.62862328
15MP0002723_abnormal_immune_serum2.52240472
16MP0002420_abnormal_adaptive_immunity2.50550319
17MP0001819_abnormal_immune_cell2.48139414
18MP0004381_abnormal_hair_follicle2.40062595
19MP0002452_abnormal_antigen_presenting2.37834758
20MP0006082_CNS_inflammation2.24585979
21MP0004947_skin_inflammation2.20866809
22MP0003191_abnormal_cellular_cholesterol2.20866637
23MP0002396_abnormal_hematopoietic_system2.15547507
24MP0001533_abnormal_skeleton_physiology2.10998259
25MP0003300_gastrointestinal_ulcer2.09974786
26MP0003172_abnormal_lysosome_physiology2.09873787
27MP0002405_respiratory_system_inflammati2.09089277
28MP0002148_abnormal_hypersensitivity_rea2.00024372
29MP0002398_abnormal_bone_marrow1.98345797
30MP0005464_abnormal_platelet_physiology1.96313121
31MP0000716_abnormal_immune_system1.89003013
32MP0008260_abnormal_autophagy1.81768303
33MP0010155_abnormal_intestine_physiology1.79061711
34MP0009333_abnormal_splenocyte_physiolog1.77555049
35MP0009278_abnormal_bone_marrow1.74073060
36MP0001851_eye_inflammation1.73062429
37MP0002132_abnormal_respiratory_system1.70329443
38MP0002796_impaired_skin_barrier1.69150526
39MP0002722_abnormal_immune_system1.66618735
40MP0001845_abnormal_inflammatory_respons1.65781804
41MP0000465_gastrointestinal_hemorrhage1.61289435
42MP0000689_abnormal_spleen_morphology1.60342187
43MP0000703_abnormal_thymus_morphology1.59624790
44MP0002429_abnormal_blood_cell1.51667390
45MP0003828_pulmonary_edema1.50718151
46MP0003866_abnormal_defecation1.43097110
47MP0000858_altered_metastatic_potential1.42728394
48MP0002166_altered_tumor_susceptibility1.35028330
49MP0005075_abnormal_melanosome_morpholog1.34979231
50MP0005451_abnormal_body_composition1.33103649
51MP0008469_abnormal_protein_level1.30787365
52MP0003878_abnormal_ear_physiology1.30196133
53MP0005377_hearing/vestibular/ear_phenot1.30196133
54MP0000015_abnormal_ear_pigmentation1.28430091
55MP0005397_hematopoietic_system_phenotyp1.25116072
56MP0001545_abnormal_hematopoietic_system1.25116072
57MP0009764_decreased_sensitivity_to1.23305677
58MP0001873_stomach_inflammation1.22901223
59MP0003183_abnormal_peptide_metabolism1.21504990
60MP0003656_abnormal_erythrocyte_physiolo1.18533466
61MP0002277_abnormal_respiratory_mucosa1.15002138
62MP0002009_preneoplasia1.14401965
63MP0005310_abnormal_salivary_gland1.12478054
64MP0002998_abnormal_bone_remodeling1.07802640
65MP0001986_abnormal_taste_sensitivity1.06137357
66MP0004883_abnormal_blood_vessel1.02600048
67MP0003453_abnormal_keratinocyte_physiol1.01665987
68MP0001853_heart_inflammation0.98573318
69MP0005058_abnormal_lysosome_morphology0.95978105
70MP0005409_darkened_coat_color0.95745786
71MP0004264_abnormal_extraembryonic_tissu0.91083945
72MP0002138_abnormal_hepatobiliary_system0.90357715
73MP0002006_tumorigenesis0.87376065
74MP0005390_skeleton_phenotype0.86604435
75MP0001216_abnormal_epidermal_layer0.85301289
76MP0004808_abnormal_hematopoietic_stem0.84421752
77MP0005174_abnormal_tail_pigmentation0.84219224
78MP0009931_abnormal_skin_appearance0.83512190
79MP0005164_abnormal_response_to0.81132793
80MP0005076_abnormal_cell_differentiation0.80411296
81MP0005501_abnormal_skin_physiology0.79883345
82MP0002933_joint_inflammation0.79067790
83MP0009763_increased_sensitivity_to0.78486690
84MP0003806_abnormal_nucleotide_metabolis0.76664186
85MP0003075_altered_response_to0.75826315
86MP0001663_abnormal_digestive_system0.71044582
87MP0000490_abnormal_crypts_of0.70992364
88MP0003045_fibrosis0.70069440
89MP0004510_myositis0.69902795
90MP0003448_altered_tumor_morphology0.68418230
91MP0005083_abnormal_biliary_tract0.67620370
92MP0005166_decreased_susceptibility_to0.66827073
93MP0002019_abnormal_tumor_incidence0.66506230
94MP0009765_abnormal_xenobiotic_induced0.65503284
95MP0004185_abnormal_adipocyte_glucose0.65252636
96MP0010234_abnormal_vibrissa_follicle0.60990284
97MP0003795_abnormal_bone_structure0.57857654
98MP0003566_abnormal_cell_adhesion0.55536545
99MP0002095_abnormal_skin_pigmentation0.52988809
100MP0004130_abnormal_muscle_cell0.51940798

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.46504431
2Recurrent bacterial skin infections (HP:0005406)5.76600497
3Myositis (HP:0100614)5.60363380
4Recurrent abscess formation (HP:0002722)5.44858064
5Increased IgE level (HP:0003212)5.33654805
6Orchitis (HP:0100796)4.96627912
7Optic neuritis (HP:0100653)4.69888193
8Retrobulbar optic neuritis (HP:0100654)4.69888193
9Abnormality of macrophages (HP:0004311)4.61582531
10Elevated erythrocyte sedimentation rate (HP:0003565)4.50848478
11Stomatitis (HP:0010280)4.49270597
12Recurrent fungal infections (HP:0002841)4.24459876
13Recurrent gram-negative bacterial infections (HP:0005420)4.18710827
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.11567425
15Gastrointestinal infarctions (HP:0005244)4.06329569
16Recurrent skin infections (HP:0001581)4.03832947
17Hypochromic microcytic anemia (HP:0004840)3.95610436
18Keratoconjunctivitis sicca (HP:0001097)3.89494646
19Keratoconjunctivitis (HP:0001096)3.77361410
20Pustule (HP:0200039)3.77270152
21Obstructive lung disease (HP:0006536)3.77050913
22Chronic obstructive pulmonary disease (HP:0006510)3.77050913
23Meningitis (HP:0001287)3.73392147
24Mediastinal lymphadenopathy (HP:0100721)3.72878416
25Recurrent cutaneous fungal infections (HP:0011370)3.67134434
26Chronic mucocutaneous candidiasis (HP:0002728)3.67134434
27Hypochromic anemia (HP:0001931)3.60987733
28Urticaria (HP:0001025)3.59264638
29Encephalitis (HP:0002383)3.51284845
30Prolonged bleeding time (HP:0003010)3.46407562
31Gingivitis (HP:0000230)3.25407832
32Panhypogammaglobulinemia (HP:0003139)3.20661817
33Vasculitis (HP:0002633)3.14855317
34Gangrene (HP:0100758)3.01131228
35Chest pain (HP:0100749)2.93453249
36Anorexia (HP:0002039)2.93368992
37Hemoptysis (HP:0002105)2.91926286
38Spontaneous hematomas (HP:0007420)2.90135479
39Gingival bleeding (HP:0000225)2.80539494
40Inflammation of the large intestine (HP:0002037)2.80286926
41Pulmonary infiltrates (HP:0002113)2.78582885
42Granulocytopenia (HP:0001913)2.77583187
43Abnormality of nail color (HP:0100643)2.74839782
44Gastrointestinal inflammation (HP:0004386)2.74254332
45Epistaxis (HP:0000421)2.71992769
46Recurrent viral infections (HP:0004429)2.71906756
47Episodic fever (HP:0001954)2.65987295
48Arterial thrombosis (HP:0004420)2.65858332
49Cellulitis (HP:0100658)2.60709783
50Leukocytosis (HP:0001974)2.56061814
51Thick nail (HP:0001805)2.52962530
52Hypergammaglobulinemia (HP:0010702)2.47367748
53Abnormality of T cells (HP:0002843)2.45891105
54Skin ulcer (HP:0200042)2.44125068
55Abnormality of T cell physiology (HP:0011840)2.41888320
56Pulmonary embolism (HP:0002204)2.40102518
57T lymphocytopenia (HP:0005403)2.39948123
58Abnormality of T cell number (HP:0011839)2.37760807
59Sepsis (HP:0100806)2.35745476
60Osteomyelitis (HP:0002754)2.28228444
61Colitis (HP:0002583)2.27547594
62Amyloidosis (HP:0011034)2.26623738
63Microcytic anemia (HP:0001935)2.25415048
64Abnormality of the pleura (HP:0002103)2.24804633
65Cheilitis (HP:0100825)2.22313014
66Petechiae (HP:0000967)2.20587199
67Peritonitis (HP:0002586)2.16514179
68Increased IgM level (HP:0003496)2.16334935
69Keratitis (HP:0000491)2.15039137
70Palmoplantar hyperkeratosis (HP:0000972)2.12456727
71Papilloma (HP:0012740)2.09151963
72Verrucae (HP:0200043)2.09151963
73Increased serum ferritin (HP:0003281)2.07424613
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.06307996
75Eosinophilia (HP:0001880)2.06252342
76Lymphopenia (HP:0001888)2.02586110
77Premature loss of primary teeth (HP:0006323)2.01555570
78Abnormality of iron homeostasis (HP:0011031)1.95677694
79Agammaglobulinemia (HP:0004432)1.95222094
80Viral hepatitis (HP:0006562)1.93844464
81Abnormality of the endocardium (HP:0004306)1.91913212
82Abnormality of cells of the lymphoid lineage (HP:0012140)1.91114869
83Palmar hyperkeratosis (HP:0010765)1.90728773
84Abnormality of the peritoneum (HP:0002585)1.90321607
85Slow saccadic eye movements (HP:0000514)1.88065266
86Parakeratosis (HP:0001036)1.87118252
87Skin rash (HP:0000988)1.86830687
88Purpura (HP:0000979)1.86705219
89Glomerulopathy (HP:0100820)1.84927490
90Abnormality of the fingertips (HP:0001211)1.84506536
91Increased cerebral lipofuscin (HP:0011813)1.84054027
92Plantar hyperkeratosis (HP:0007556)1.83667553
93Hepatosplenomegaly (HP:0001433)1.82227178
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81977032
95Abnormality of the pericardium (HP:0001697)1.81470454
96Chronic otitis media (HP:0000389)1.79764020
97Vertigo (HP:0002321)1.79655574
98Loss of speech (HP:0002371)1.79628070
99Abnormal blistering of the skin (HP:0008066)1.78055389
100Abnormality of eosinophils (HP:0001879)1.77878875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.28868635
2MAP4K13.66130190
3MAP2K33.29488676
4BLK2.98308002
5ERN12.95098285
6IRAK42.83544745
7TNK22.53646265
8TYK22.48328022
9FES2.35218442
10CSK2.28155607
11ZAP702.18441462
12TXK2.07511831
13* GRK62.05122756
14BTK2.01194689
15PRPF4B1.97107191
16MAP3K31.95150523
17JAK31.80025909
18TAOK31.74053632
19EPHB11.73972662
20MAP3K141.70851513
21HCK1.63878432
22SYK1.63277810
23MAP3K131.62410758
24TRIB31.60590470
25MAP3K61.52341696
26TAOK11.51432723
27MAP3K111.51133547
28IKBKE1.44071055
29TBK11.42684298
30SIK31.40848046
31KIT1.37936753
32MAP3K11.37305718
33FGR1.32558989
34SIK21.29736685
35PRKD21.28569341
36ITK1.26003142
37LYN1.25507863
38MARK31.20282603
39MAP3K21.19105948
40KSR21.17888870
41JAK11.17301063
42IKBKB1.16678614
43LCK1.16119138
44TEC1.10217410
45SMG11.08389998
46SIK11.08175196
47JAK21.06903549
48MAP2K61.06021414
49CSF1R1.05969266
50MARK21.04316745
51MAP3K71.01746105
52MAPK70.95006780
53PTK60.92257821
54IRAK10.91527834
55YES10.84690130
56FGFR30.83336093
57CDK120.82105789
58MATK0.81904578
59FGFR40.79538392
60HIPK20.79014354
61PDK10.76650790
62MAPK120.74182114
63MAP2K40.72943404
64STK100.71964499
65PDPK10.68987860
66RPS6KL10.64682424
67RPS6KC10.64682424
68IRAK20.63208617
69PTK2B0.61173957
70TESK20.61048650
71CDC42BPA0.60403894
72RPS6KA60.59757122
73PIK3CG0.56377489
74CDK40.54789581
75RAF10.54643466
76FYN0.52113961
77MAP2K20.51610580
78MAPKAPK20.51571051
79RET0.50791155
80CDK190.46895297
81TAOK20.44861847
82PRKCQ0.44441421
83LRRK20.42711554
84BMPR20.42658073
85STK110.42075346
86EPHA30.40624744
87MUSK0.40236315
88SGK30.39463818
89RPS6KA20.39296424
90BRD40.37786849
91TGFBR20.33469107
92PIM10.33389483
93PKN20.32525753
94DYRK1B0.31272041
95MAPK110.29711250
96ABL10.28590474
97RPS6KA10.27254546
98CHUK0.24425855
99STK380.24291629
100PRKCH0.24185602

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.92232184
2Osteoclast differentiation_Homo sapiens_hsa043802.88946479
3Staphylococcus aureus infection_Homo sapiens_hsa051502.67175754
4Primary immunodeficiency_Homo sapiens_hsa053402.36720348
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32085854
6B cell receptor signaling pathway_Homo sapiens_hsa046622.31989521
7Graft-versus-host disease_Homo sapiens_hsa053322.29868789
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.13397876
9Allograft rejection_Homo sapiens_hsa053302.07224155
10Tuberculosis_Homo sapiens_hsa051522.03999000
11Acute myeloid leukemia_Homo sapiens_hsa052212.00547086
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00293221
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.98904869
14Autoimmune thyroid disease_Homo sapiens_hsa053201.91242022
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89790361
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83823652
17Malaria_Homo sapiens_hsa051441.80781791
18T cell receptor signaling pathway_Homo sapiens_hsa046601.77561658
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72449971
20Measles_Homo sapiens_hsa051621.71488454
21Hematopoietic cell lineage_Homo sapiens_hsa046401.69434466
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.63739980
23Other glycan degradation_Homo sapiens_hsa005111.62303452
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57958300
25Antigen processing and presentation_Homo sapiens_hsa046121.54142514
26Toxoplasmosis_Homo sapiens_hsa051451.54027107
27Influenza A_Homo sapiens_hsa051641.53221717
28Type I diabetes mellitus_Homo sapiens_hsa049401.49425912
29Herpes simplex infection_Homo sapiens_hsa051681.47722887
30Chemokine signaling pathway_Homo sapiens_hsa040621.46142607
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.39731752
32Non-small cell lung cancer_Homo sapiens_hsa052231.37623741
33TNF signaling pathway_Homo sapiens_hsa046681.27829592
34Platelet activation_Homo sapiens_hsa046111.26310600
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.24854881
36Asthma_Homo sapiens_hsa053101.22953977
37VEGF signaling pathway_Homo sapiens_hsa043701.21948893
38African trypanosomiasis_Homo sapiens_hsa051431.20322453
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19373608
40Hepatitis B_Homo sapiens_hsa051611.16484934
41Viral myocarditis_Homo sapiens_hsa054161.13404984
42Hepatitis C_Homo sapiens_hsa051601.11223637
43Legionellosis_Homo sapiens_hsa051341.10564212
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.09629896
45Pancreatic cancer_Homo sapiens_hsa052121.09506834
46Chronic myeloid leukemia_Homo sapiens_hsa052201.07664436
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05853349
48Pertussis_Homo sapiens_hsa051330.98802043
49Phagosome_Homo sapiens_hsa041450.96461253
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93686866
51Shigellosis_Homo sapiens_hsa051310.92754058
52Notch signaling pathway_Homo sapiens_hsa043300.91783366
53Prolactin signaling pathway_Homo sapiens_hsa049170.86100951
54Apoptosis_Homo sapiens_hsa042100.84925469
55Choline metabolism in cancer_Homo sapiens_hsa052310.84807466
56GnRH signaling pathway_Homo sapiens_hsa049120.83285442
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.82218449
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.81353664
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.81352728
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77134808
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.75068418
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.75048385
63Salmonella infection_Homo sapiens_hsa051320.73818650
64Dorso-ventral axis formation_Homo sapiens_hsa043200.73539675
65Epstein-Barr virus infection_Homo sapiens_hsa051690.71779355
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71122248
67Lysosome_Homo sapiens_hsa041420.68995461
68Renal cell carcinoma_Homo sapiens_hsa052110.68978341
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.67957371
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65877667
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65094757
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64679380
73Endocytosis_Homo sapiens_hsa041440.64523014
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64003622
75Rheumatoid arthritis_Homo sapiens_hsa053230.63866009
76Insulin resistance_Homo sapiens_hsa049310.62457193
77mTOR signaling pathway_Homo sapiens_hsa041500.61714457
78FoxO signaling pathway_Homo sapiens_hsa040680.60766831
79HTLV-I infection_Homo sapiens_hsa051660.60377620
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59821826
81Amoebiasis_Homo sapiens_hsa051460.58914266
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58621531
83Regulation of autophagy_Homo sapiens_hsa041400.58498422
84Inositol phosphate metabolism_Homo sapiens_hsa005620.57286089
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57230742
86Viral carcinogenesis_Homo sapiens_hsa052030.56513924
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56452182
88MAPK signaling pathway_Homo sapiens_hsa040100.55442916
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54049184
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53199605
91Endometrial cancer_Homo sapiens_hsa052130.51342483
92Colorectal cancer_Homo sapiens_hsa052100.49107337
93Prostate cancer_Homo sapiens_hsa052150.46082037
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45058457
95Type II diabetes mellitus_Homo sapiens_hsa049300.44996069
96Arachidonic acid metabolism_Homo sapiens_hsa005900.44965255
97Glioma_Homo sapiens_hsa052140.43265429
98Bladder cancer_Homo sapiens_hsa052190.41179872
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39852200
100HIF-1 signaling pathway_Homo sapiens_hsa040660.39208129

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