LTB4R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.16381898
2viral transcription (GO:0019083)6.90049183
3hemidesmosome assembly (GO:0031581)6.53435750
4translational termination (GO:0006415)6.47229335
5ribosomal small subunit biogenesis (GO:0042274)6.19940197
6maturation of SSU-rRNA (GO:0030490)5.91582958
7positive regulation of gamma-delta T cell activation (GO:0046645)5.30593947
8translational elongation (GO:0006414)5.21880893
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.21225741
10regulation of phospholipase A2 activity (GO:0032429)5.14795223
11protein targeting to ER (GO:0045047)5.13180365
12negative regulation of erythrocyte differentiation (GO:0045647)5.11239251
13cotranslational protein targeting to membrane (GO:0006613)5.08944957
14viral life cycle (GO:0019058)5.07709749
15detection of bacterium (GO:0016045)5.01794363
16regulation of water loss via skin (GO:0033561)5.00043803
17cellular protein complex disassembly (GO:0043624)4.95367870
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.94518677
19response to peptidoglycan (GO:0032494)4.92488039
20ribosomal large subunit biogenesis (GO:0042273)4.90196338
21ribosomal small subunit assembly (GO:0000028)4.88667359
22protein localization to endoplasmic reticulum (GO:0070972)4.83841750
23intestinal cholesterol absorption (GO:0030299)4.83549070
24bundle of His cell to Purkinje myocyte communication (GO:0086069)4.72242348
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.68951233
26phospholipid efflux (GO:0033700)4.67812290
27establishment of skin barrier (GO:0061436)4.65236029
28response to muramyl dipeptide (GO:0032495)4.64898581
29positive regulation by symbiont of host defense response (GO:0052509)4.58450589
30modulation by symbiont of host defense response (GO:0052031)4.58450589
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58450589
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58450589
33positive regulation by organism of defense response of other organism involved in symbiotic interact4.58450589
34modulation by symbiont of host immune response (GO:0052553)4.58450589
35detection of other organism (GO:0098543)4.51978025
36negative regulation of cell killing (GO:0031342)4.49418495
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49418495
38intestinal absorption (GO:0050892)4.47155439
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.41597330
40fatty acid elongation (GO:0030497)4.28545358
41regulation of chemokine secretion (GO:0090196)4.22108262
42atrioventricular valve morphogenesis (GO:0003181)4.20080710
43protein complex disassembly (GO:0043241)4.18813986
44cellular extravasation (GO:0045123)4.15801446
45leukocyte aggregation (GO:0070486)4.15478004
46keratinocyte proliferation (GO:0043616)4.12889561
47translational initiation (GO:0006413)4.10322481
48angiotensin maturation (GO:0002003)4.07994414
49regulation of triglyceride catabolic process (GO:0010896)3.96254923
50regulation of gamma-delta T cell activation (GO:0046643)3.95815301
51sphingoid metabolic process (GO:0046519)3.94856850
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90183150
53negative thymic T cell selection (GO:0045060)3.88547594
54interferon-gamma secretion (GO:0072643)3.88058316
55antigen processing and presentation of endogenous antigen (GO:0019883)3.84946989
56positive thymic T cell selection (GO:0045059)3.82854778
57regulation of natural killer cell differentiation (GO:0032823)3.82758518
58macromolecular complex disassembly (GO:0032984)3.81390192
59regulation of cholesterol esterification (GO:0010872)3.81118385
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78717453
61adhesion of symbiont to host cell (GO:0044650)3.77581628
62virion attachment to host cell (GO:0019062)3.77581628
63detection of external biotic stimulus (GO:0098581)3.72933941
64thymic T cell selection (GO:0045061)3.69312530
65macrophage activation involved in immune response (GO:0002281)3.66949907
66keratinization (GO:0031424)3.66798307
67negative T cell selection (GO:0043383)3.64681061
68regulation of B cell receptor signaling pathway (GO:0050855)3.64273687
69keratinocyte differentiation (GO:0030216)3.63082821
70regulation of gamma-delta T cell differentiation (GO:0045586)3.60420439
71very long-chain fatty acid metabolic process (GO:0000038)3.59649933
72negative regulation of T cell mediated immunity (GO:0002710)3.58056189
73neutrophil activation involved in immune response (GO:0002283)3.57123631
74protein targeting to membrane (GO:0006612)3.55796203
75fatty-acyl-CoA metabolic process (GO:0035337)3.53391933
76carnitine metabolic process (GO:0009437)3.50957717
77positive regulation of interleukin-8 secretion (GO:2000484)3.50652955
78negative regulation of sterol transport (GO:0032372)3.48923895
79negative regulation of cholesterol transport (GO:0032375)3.48923895
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48323495
81negative regulation of lipase activity (GO:0060192)3.45542128
82long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.44482776
83multicellular organismal water homeostasis (GO:0050891)3.40763927
84negative regulation of lymphocyte mediated immunity (GO:0002707)3.39912109
85T cell selection (GO:0045058)3.39885811
86sphingosine metabolic process (GO:0006670)3.39262083
87negative regulation of interleukin-12 production (GO:0032695)3.38610186
88response to host immune response (GO:0052572)3.38356546
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.38356546
90regulation of hypersensitivity (GO:0002883)3.37784702
91detection of biotic stimulus (GO:0009595)3.36803925
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36347352
93response to host (GO:0075136)3.36347352
94response to host defenses (GO:0052200)3.36347352
95high-density lipoprotein particle remodeling (GO:0034375)3.34673153
963-UTR-mediated mRNA stabilization (GO:0070935)3.34463795
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32333031
98amino-acid betaine metabolic process (GO:0006577)3.30844512
99regulation of cholesterol homeostasis (GO:2000188)3.28331074
100regulation of glucocorticoid metabolic process (GO:0031943)3.27839288
101regulation of apoptotic process involved in morphogenesis (GO:1902337)3.26788796
102primary alcohol catabolic process (GO:0034310)3.25780215
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.21522075
104epidermis development (GO:0008544)3.21483920
105regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.21223715
106germinal center formation (GO:0002467)3.21113293
107positive regulation of B cell differentiation (GO:0045579)3.20339356
108adhesion of symbiont to host (GO:0044406)3.18905252
109mannose metabolic process (GO:0006013)3.17876553
110detection of molecule of bacterial origin (GO:0032490)3.15499416
111plasma lipoprotein particle assembly (GO:0034377)3.14981764
112B cell receptor signaling pathway (GO:0050853)3.13748144
113regulation of ruffle assembly (GO:1900027)3.12672697
114response to phenylpropanoid (GO:0080184)3.12270174
115urea cycle (GO:0000050)3.11895548
116urea metabolic process (GO:0019627)3.11895548
117regulation of leukocyte degranulation (GO:0043300)3.10382144
118positive regulation of p38MAPK cascade (GO:1900745)3.10077845
119diol metabolic process (GO:0034311)3.09274265
120negative regulation of interferon-gamma production (GO:0032689)3.09172701
121keratinocyte development (GO:0003334)3.06639803
122antigen processing and presentation via MHC class Ib (GO:0002475)3.06607080
123positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.06524511
124negative regulation of leukocyte mediated immunity (GO:0002704)3.05941040
125regulation of mast cell degranulation (GO:0043304)3.05077283
126positive regulation of lipoprotein lipase activity (GO:0051006)3.04219618
127positive regulation of triglyceride lipase activity (GO:0061365)3.04219618
128planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04218041
129positive T cell selection (GO:0043368)3.03668539
130epidermal cell differentiation (GO:0009913)3.03049787
131negative regulation of stress fiber assembly (GO:0051497)3.01596780
132skin morphogenesis (GO:0043589)3.00540012
133regulation of interferon-beta biosynthetic process (GO:0045357)2.99664277
134water homeostasis (GO:0030104)2.98657450
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95900187
136positive regulation of chemokine secretion (GO:0090197)2.93873737
137molting cycle (GO:0042303)2.92235557
138hair cycle (GO:0042633)2.92235557
139lipoprotein metabolic process (GO:0042157)2.91678765
140cholesterol efflux (GO:0033344)2.90396580
141respiratory burst (GO:0045730)2.87410043
142flavonoid metabolic process (GO:0009812)2.87374133
143cholesterol homeostasis (GO:0042632)2.86415683
144myeloid cell activation involved in immune response (GO:0002275)2.85349567
145gland morphogenesis (GO:0022612)2.85220180
146protein-lipid complex remodeling (GO:0034368)2.85125991
147macromolecular complex remodeling (GO:0034367)2.85125991
148plasma lipoprotein particle remodeling (GO:0034369)2.85125991
149negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84553721
150peptidyl-glutamic acid carboxylation (GO:0017187)2.84285558
151protein carboxylation (GO:0018214)2.84285558
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84261974
153regulation of interleukin-8 secretion (GO:2000482)2.83520798
154negative regulation of interleukin-8 production (GO:0032717)2.82693173
155protein-lipid complex assembly (GO:0065005)2.82607517
156tolerance induction (GO:0002507)2.81971408
157regulation of B cell differentiation (GO:0045577)2.81507181
158fibrinolysis (GO:0042730)2.81291238
159positive regulation of fatty acid biosynthetic process (GO:0045723)2.80131149
160reverse cholesterol transport (GO:0043691)2.79724160
161response to laminar fluid shear stress (GO:0034616)2.76138590
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72975946
163response to interleukin-15 (GO:0070672)2.71697925
164regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71404567
165regulation of mast cell activation involved in immune response (GO:0033006)2.71279424
166neutrophil activation (GO:0042119)2.71162333
167neutrophil mediated immunity (GO:0002446)2.69245427
168negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.67834849
169histone H3-K36 demethylation (GO:0070544)2.67783202
170negative regulation of interleukin-6 production (GO:0032715)2.67664259
171positive regulation of granulocyte differentiation (GO:0030854)2.65427842
172immunoglobulin mediated immune response (GO:0016064)2.62105871
173embryonic process involved in female pregnancy (GO:0060136)2.61817510
174granulocyte activation (GO:0036230)2.58595023
175positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58154866
176positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57291880
177regulation of necroptotic process (GO:0060544)2.57076346
178T cell migration (GO:0072678)2.56298806
179Peyers patch development (GO:0048541)2.55839726
180mucosal-associated lymphoid tissue development (GO:0048537)2.55839726
181macrophage activation (GO:0042116)2.54390065
182defense response to protozoan (GO:0042832)2.54328916
183pinocytosis (GO:0006907)2.52889505
184negative regulation of toll-like receptor signaling pathway (GO:0034122)2.52045417
185negative regulation of innate immune response (GO:0045824)2.51812693
186regulation of histone H3-K27 methylation (GO:0061085)2.51346119
187histone H3-K4 trimethylation (GO:0080182)2.48417181
188response to protozoan (GO:0001562)2.46476184
189regulation of regulated secretory pathway (GO:1903305)2.46464991
190positive regulation of Cdc42 GTPase activity (GO:0043089)2.46298224
191megakaryocyte development (GO:0035855)2.45776872
192NIK/NF-kappaB signaling (GO:0038061)2.43833576
193leukocyte migration involved in inflammatory response (GO:0002523)2.43611773
194microglial cell activation (GO:0001774)2.43349779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.62285841
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.01408469
3GATA1_22025678_ChIP-Seq_K562_Human3.56725224
4MYC_22102868_ChIP-Seq_BL_Human3.54018887
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95034797
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85856950
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.84966735
8ZNF263_19887448_ChIP-Seq_K562_Human2.66217082
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.59848876
10VDR_24763502_ChIP-Seq_THP-1_Human2.57348967
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53005763
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.51778024
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48511240
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.47235849
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.43627143
16MAF_26560356_Chip-Seq_TH1_Human2.39726203
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38920318
18* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.31652138
19KDM2B_26808549_Chip-Seq_DND41_Human2.25649007
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19346765
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.16244069
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.12150112
23UTX_26944678_Chip-Seq_JUKART_Human2.10221621
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09668480
25LXR_22158963_ChIP-Seq_LIVER_Mouse2.06943459
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06719382
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.00298505
28TP63_17297297_ChIP-ChIP_HaCaT_Human14.5492306
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99837206
30* MAF_26560356_Chip-Seq_TH2_Human1.96733739
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96255741
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.95961755
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93138830
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88794611
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81008058
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.79343088
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78040345
38E2F7_22180533_ChIP-Seq_HELA_Human1.77509364
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77190002
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75305410
41SPI1_23547873_ChIP-Seq_NB4_Human1.73943158
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.71295307
43MYB_26560356_Chip-Seq_TH1_Human1.69866625
44MYB_26560356_Chip-Seq_TH2_Human1.67499632
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64178572
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.62103494
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60330364
48RUNX_20019798_ChIP-Seq_JUKART_Human1.59859336
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56920024
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.55597918
51SPI1_23127762_ChIP-Seq_K562_Human1.55590186
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53892035
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53892035
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49789448
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.49371100
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49275439
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45249222
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41842980
59* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40835710
60P68_20966046_ChIP-Seq_HELA_Human1.40389680
61LXR_22292898_ChIP-Seq_THP-1_Human1.39662975
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39096317
63RACK7_27058665_Chip-Seq_MCF-7_Human1.37256750
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35585940
65SOX2_20726797_ChIP-Seq_SW620_Human1.35457168
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34389093
67* GATA1_19941827_ChIP-Seq_MEL_Mouse1.34053237
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33689108
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.32799555
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32234188
71NCOR1_26117541_ChIP-Seq_K562_Human1.31936768
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31933129
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31226459
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30543995
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29482275
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29139536
77ATF3_27146783_Chip-Seq_COLON_Human1.28618625
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25433131
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24561799
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23865325
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23366276
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22962041
83CIITA_25753668_ChIP-Seq_RAJI_Human1.22506592
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20784615
85KDM2B_26808549_Chip-Seq_K562_Human1.20754815
86BCL6_27268052_Chip-Seq_Bcells_Human1.20353757
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19924887
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19471450
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18058074
90* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17991687
91GATA6_25053715_ChIP-Seq_YYC3_Human1.17965265
92* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17808120
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17507205
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.16937487
95* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16524088
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.15925107
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13800956
98GATA4_25053715_ChIP-Seq_YYC3_Human1.13472542
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13067616
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12822319
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12501351
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12037310
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11005604
104* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10797732
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09990216
106SMC4_20622854_ChIP-Seq_HELA_Human1.09633912
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08786178
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08338338
109* TP63_22573176_ChIP-Seq_HFKS_Human1.08146171
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08019998
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07647561
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06679554
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06043567
114VDR_21846776_ChIP-Seq_THP-1_Human1.06006367
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02236657
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02036560
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.01333233
118PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00892574
119* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99478166
120ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99257379
121KLF5_25053715_ChIP-Seq_YYC3_Human0.99199480
122PU_27001747_Chip-Seq_BMDM_Mouse0.97791619
123GATA3_27048872_Chip-Seq_THYMUS_Human0.96403899
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96258778
125TCF7_22412390_ChIP-Seq_EML_Mouse0.95956123
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94497360
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94367440
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94346248
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.94142330
130MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93855086
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93207426
132EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90681630
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89108957
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.89000348
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88223140
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88223140
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88223140
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87682874
139RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86872629
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85735928
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.85388709
142NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84837543
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84304012
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.82646691
145SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81741524
146RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79407330
147MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75634949
148* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75544926
149ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75098857
150BCOR_27268052_Chip-Seq_Bcells_Human0.74398630
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73424144
152TP63_23658742_ChIP-Seq_EP156T_Human0.72967902
153OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71818232
154SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71669073
155UBF1/2_26484160_Chip-Seq_HMECs_Human0.71075033
156* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70553693
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.68604083
158HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.68196240
159IRF8_22096565_ChIP-ChIP_GC-B_Human0.68143914
160* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.66556182
161CREB1_26743006_Chip-Seq_LNCaP_Human0.66273170
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66157553
163PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65689054
164RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.65477726
165MYC_18555785_ChIP-Seq_MESCs_Mouse0.65396202
166SCL_19346495_ChIP-Seq_HPC-7_Human0.64784452
167POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.64767597
168GATA1_19941826_ChIP-Seq_K562_Human0.63168687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.74612982
2MP0002254_reproductive_system_inflammat5.21840039
3MP0010234_abnormal_vibrissa_follicle4.59879632
4MP0005360_urolithiasis4.58675370
5MP0005501_abnormal_skin_physiology3.32325049
6MP0003941_abnormal_skin_development3.22414070
7MP0001346_abnormal_lacrimal_gland3.07228422
8MP0000467_abnormal_esophagus_morphology2.98742464
9MP0000579_abnormal_nail_morphology2.93488897
10MP0002060_abnormal_skin_morphology2.88700810
11MP0002098_abnormal_vibrissa_morphology2.88339216
12MP0003763_abnormal_thymus_physiology2.79208391
13MP0001216_abnormal_epidermal_layer2.69578372
14MP0001835_abnormal_antigen_presentation2.61205769
15MP0001666_abnormal_nutrient_absorption2.60124468
16MP0005275_abnormal_skin_tensile2.57703888
17MP0010678_abnormal_skin_adnexa2.57555888
18MP0000685_abnormal_immune_system2.55056834
19MP0005085_abnormal_gallbladder_physiolo2.51741479
20MP0009379_abnormal_foot_pigmentation2.50755669
21MP0009278_abnormal_bone_marrow2.49936336
22MP0000383_abnormal_hair_follicle2.47257835
23MP0003303_peritoneal_inflammation2.45964292
24MP0003705_abnormal_hypodermis_morpholog2.36426117
25MP0002396_abnormal_hematopoietic_system2.33358300
26MP0002139_abnormal_hepatobiliary_system2.32482559
27MP0004381_abnormal_hair_follicle2.22343987
28MP0001800_abnormal_humoral_immune2.21516216
29* MP0002419_abnormal_innate_immunity2.19516178
30MP0003453_abnormal_keratinocyte_physiol2.18895748
31MP0010771_integument_phenotype2.16210356
32MP0008260_abnormal_autophagy2.10975276
33* MP0005000_abnormal_immune_tolerance2.07083389
34MP0009840_abnormal_foam_cell2.06562500
35MP0003172_abnormal_lysosome_physiology2.02862173
36MP0003566_abnormal_cell_adhesion2.00458395
37* MP0002420_abnormal_adaptive_immunity1.99124960
38MP0009333_abnormal_splenocyte_physiolog1.98140824
39MP0004947_skin_inflammation1.98089470
40* MP0001819_abnormal_immune_cell1.97285462
41MP0008875_abnormal_xenobiotic_pharmacok1.95792075
42MP0010352_gastrointestinal_tract_polyps1.93817550
43MP0000377_abnormal_hair_follicle1.93244447
44MP0002723_abnormal_immune_serum1.92503515
45MP0002452_abnormal_antigen_presenting1.91528474
46MP0000647_abnormal_sebaceous_gland1.88270206
47MP0005387_immune_system_phenotype1.85527955
48MP0001790_abnormal_immune_system1.85527955
49MP0005671_abnormal_response_to1.84694186
50MP0002398_abnormal_bone_marrow1.82507609
51MP0005365_abnormal_bile_salt1.75925430
52MP0000427_abnormal_hair_cycle1.71787450
53MP0004019_abnormal_vitamin_homeostasis1.65778386
54MP0005058_abnormal_lysosome_morphology1.64716387
55MP0002405_respiratory_system_inflammati1.61850177
56MP0000716_abnormal_immune_system1.61632580
57MP0003806_abnormal_nucleotide_metabolis1.60619674
58MP0002722_abnormal_immune_system1.59476670
59MP0001191_abnormal_skin_condition1.58420348
60MP0000703_abnormal_thymus_morphology1.55459927
61MP0005464_abnormal_platelet_physiology1.55152370
62MP0010329_abnormal_lipoprotein_level1.52614387
63MP0000465_gastrointestinal_hemorrhage1.50097405
64MP0009931_abnormal_skin_appearance1.48323784
65MP0009785_altered_susceptibility_to1.47459835
66MP0000516_abnormal_urinary_system1.46302912
67MP0005367_renal/urinary_system_phenotyp1.46302912
68MP0005023_abnormal_wound_healing1.45887402
69MP0003828_pulmonary_edema1.44262048
70MP0000689_abnormal_spleen_morphology1.44217998
71MP0004808_abnormal_hematopoietic_stem1.39624263
72MP0002429_abnormal_blood_cell1.37614454
73MP0008057_abnormal_DNA_replication1.35066687
74MP0000762_abnormal_tongue_morphology1.32982697
75MP0001849_ear_inflammation1.29268396
76MP0003866_abnormal_defecation1.28958889
77MP0005409_darkened_coat_color1.27684552
78MP0009053_abnormal_anal_canal1.26871621
79MP0001873_stomach_inflammation1.26137192
80MP0001851_eye_inflammation1.23974305
81MP0003252_abnormal_bile_duct1.23047300
82MP0001845_abnormal_inflammatory_respons1.22702524
83MP0010030_abnormal_orbit_morphology1.17594025
84MP0006082_CNS_inflammation1.15060461
85MP0005310_abnormal_salivary_gland1.13447485
86MP0004264_abnormal_extraembryonic_tissu1.11625081
87MP0001348_abnormal_lacrimal_gland1.09815363
88MP0004510_myositis1.08278213
89MP0009384_cardiac_valve_regurgitation1.07613640
90MP0001243_abnormal_dermal_layer1.06234847
91MP0003656_abnormal_erythrocyte_physiolo1.06110382
92MP0002998_abnormal_bone_remodeling1.02537409
93MP0000015_abnormal_ear_pigmentation1.00672149
94MP0001340_abnormal_eyelid_morphology0.99562038
95MP0002019_abnormal_tumor_incidence0.98148627
96MP0002877_abnormal_melanocyte_morpholog0.97209505
97MP0000367_abnormal_coat/_hair0.96865041
98MP0000490_abnormal_crypts_of0.95330178
99MP0008469_abnormal_protein_level0.95181364
100MP0000538_abnormal_urinary_bladder0.93036343
101MP0002132_abnormal_respiratory_system0.92672199
102* MP0003436_decreased_susceptibility_to0.90872166
103MP0003191_abnormal_cellular_cholesterol0.90628282
104MP0002249_abnormal_larynx_morphology0.90289434
105MP0005076_abnormal_cell_differentiation0.90101785
106MP0004185_abnormal_adipocyte_glucose0.88406287
107MP0005666_abnormal_adipose_tissue0.86921358
108MP0005621_abnormal_cell_physiology0.84968988
109MP0003385_abnormal_body_wall0.84475588
110MP0003183_abnormal_peptide_metabolism0.80493628
111MP0000627_abnormal_mammary_gland0.78114359
112MP0005451_abnormal_body_composition0.75828752
113MP0000566_synostosis0.75006394
114MP0003448_altered_tumor_morphology0.74940046
115MP0003724_increased_susceptibility_to0.74903036
116MP0008961_abnormal_basal_metabolism0.74196349
117MP0003091_abnormal_cell_migration0.72711388
118MP0004272_abnormal_basement_membrane0.71962709
119MP0003011_delayed_dark_adaptation0.70822373
120MP0000609_abnormal_liver_physiology0.70284308
121MP0003638_abnormal_response/metabolism_0.69673729
122MP0003111_abnormal_nucleus_morphology0.68719567
123MP0002933_joint_inflammation0.68459975
124MP0005397_hematopoietic_system_phenotyp0.67721336
125MP0001545_abnormal_hematopoietic_system0.67721336
126MP0005375_adipose_tissue_phenotype0.65350203
127MP0002111_abnormal_tail_morphology0.65224336
128MP0002148_abnormal_hypersensitivity_rea0.63589029
129MP0009763_increased_sensitivity_to0.63425420
130MP0002118_abnormal_lipid_homeostasis0.63415613
131MP0010155_abnormal_intestine_physiology0.62456279
132MP0000613_abnormal_salivary_gland0.60666023
133MP0005623_abnormal_meninges_morphology0.60595336
134MP0009765_abnormal_xenobiotic_induced0.58784402
135MP0003136_yellow_coat_color0.58638038
136MP0000477_abnormal_intestine_morphology0.57674724
137MP0008007_abnormal_cellular_replicative0.55628993
138MP0002282_abnormal_trachea_morphology0.55321398
139MP0009764_decreased_sensitivity_to0.54435454
140MP0006054_spinal_hemorrhage0.51557687
141MP0003300_gastrointestinal_ulcer0.51145230
142MP0005319_abnormal_enzyme/_coenzyme0.49939539
143MP0000858_altered_metastatic_potential0.49529372
144MP0002006_tumorigenesis0.49239334
145MP0005332_abnormal_amino_acid0.49023296
146MP0009643_abnormal_urine_homeostasis0.48742849
147MP0000470_abnormal_stomach_morphology0.45662426
148MP0005083_abnormal_biliary_tract0.45218774
149MP0002009_preneoplasia0.44326913
150MP0001853_heart_inflammation0.43542166
151MP0002166_altered_tumor_susceptibility0.42565439
152MP0005025_abnormal_response_to0.42506005
153MP0000537_abnormal_urethra_morphology0.42265927
154MP0003075_altered_response_to0.41972163
155MP0002090_abnormal_vision0.41038532
156* MP0001533_abnormal_skeleton_physiology0.40385839
157MP0004858_abnormal_nervous_system0.40243835

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.74483147
2Fragile nails (HP:0001808)5.25190793
3Abnormality of cells of the erythroid lineage (HP:0012130)5.09008641
4Woolly hair (HP:0002224)5.00466894
5Parakeratosis (HP:0001036)4.87884875
6Right ventricular cardiomyopathy (HP:0011663)4.79762346
7Recurrent bacterial skin infections (HP:0005406)4.76307012
8Hypotrichosis (HP:0001006)4.74905825
9Plantar hyperkeratosis (HP:0007556)4.61302333
10Increased IgE level (HP:0003212)4.29198736
11Abnormal hemoglobin (HP:0011902)4.21687542
12Reticulocytopenia (HP:0001896)4.15643497
13Recurrent abscess formation (HP:0002722)4.07991039
14Onycholysis (HP:0001806)4.02599632
15Abnormal number of erythroid precursors (HP:0012131)3.87431349
16Milia (HP:0001056)3.82465376
17Macrocytic anemia (HP:0001972)3.81863536
18Myositis (HP:0100614)3.78141161
19Xanthomatosis (HP:0000991)3.75772398
20Hypobetalipoproteinemia (HP:0003563)3.67133052
21Erythema (HP:0010783)3.65491216
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.58180672
23Pili torti (HP:0003777)3.57595945
24Recurrent fungal infections (HP:0002841)3.57337929
25Abnormality of macrophages (HP:0004311)3.53709462
26Abnormality of the axillary hair (HP:0100134)3.46800625
27Abnormality of secondary sexual hair (HP:0009888)3.46800625
28Recurrent skin infections (HP:0001581)3.45010513
29Recurrent gram-negative bacterial infections (HP:0005420)3.32324720
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32181749
31Chronic mucocutaneous candidiasis (HP:0002728)3.32068447
32Recurrent cutaneous fungal infections (HP:0011370)3.32068447
33Abnormal blistering of the skin (HP:0008066)3.30291958
34Abnormality of the 2nd finger (HP:0004100)3.23494660
35Palmoplantar hyperkeratosis (HP:0000972)3.23378005
36Mediastinal lymphadenopathy (HP:0100721)3.21633971
37Orchitis (HP:0100796)3.17151182
38Intrahepatic cholestasis (HP:0001406)3.13459776
39Congenital ichthyosiform erythroderma (HP:0007431)3.11885286
40Pallor (HP:0000980)3.10619757
41Nail dystrophy (HP:0008404)3.09225016
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.05687063
43Sparse eyelashes (HP:0000653)3.04115195
44Palmar hyperkeratosis (HP:0010765)3.02148597
45Meningitis (HP:0001287)3.00603682
46Acanthocytosis (HP:0001927)2.96473271
47Severe Myopia (HP:0011003)2.93666983
48Elevated erythrocyte sedimentation rate (HP:0003565)2.93196723
49Retrobulbar optic neuritis (HP:0100654)2.92215150
50Optic neuritis (HP:0100653)2.92215150
51Recurrent viral infections (HP:0004429)2.88366589
52Gastrointestinal infarctions (HP:0005244)2.88351231
53Colitis (HP:0002583)2.82978410
54Erythroderma (HP:0001019)2.79704655
55Panhypogammaglobulinemia (HP:0003139)2.78240374
56Gastrointestinal inflammation (HP:0004386)2.77898440
57Cellulitis (HP:0100658)2.75982228
58Keratoconjunctivitis sicca (HP:0001097)2.75676611
59Abnormality of the fingertips (HP:0001211)2.74400826
60Chronic obstructive pulmonary disease (HP:0006510)2.70865307
61Obstructive lung disease (HP:0006536)2.70865307
62Gingivitis (HP:0000230)2.70239742
63Stenosis of the external auditory canal (HP:0000402)2.67939461
64Down-sloping shoulders (HP:0200021)2.65082370
65Malnutrition (HP:0004395)2.65058542
66Abnormality of nail color (HP:0100643)2.63033119
67Vascular calcification (HP:0004934)2.58619297
68Abnormal hair laboratory examination (HP:0003328)2.56670156
69Gangrene (HP:0100758)2.55941525
70Hypohidrosis (HP:0000966)2.55887357
71Inflammation of the large intestine (HP:0002037)2.54449173
72Keratoconjunctivitis (HP:0001096)2.54105038
73Sparse scalp hair (HP:0002209)2.53583538
74Atrophic scars (HP:0001075)2.50150849
75Prolonged bleeding time (HP:0003010)2.49496182
76Hydroxyprolinuria (HP:0003080)2.49271032
77Abnormality of proline metabolism (HP:0010907)2.49271032
78Trismus (HP:0000211)2.43803992
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.42837569
80Amyloidosis (HP:0011034)2.41795237
81Pruritus (HP:0000989)2.40988861
82Lip pit (HP:0100267)2.40662214
83Ileus (HP:0002595)2.39460490
84Abnormality of reticulocytes (HP:0004312)2.38854414
85Skin ulcer (HP:0200042)2.37127059
86Hypolipoproteinemia (HP:0010981)2.36527591
87Viral hepatitis (HP:0006562)2.35871960
88Abnormality of the gastric mucosa (HP:0004295)2.33176325
89Mesangial abnormality (HP:0001966)2.32155296
90Distal lower limb muscle weakness (HP:0009053)2.32144829
91Acanthosis nigricans (HP:0000956)2.32005484
92Cardiovascular calcification (HP:0011915)2.30823824
93Encephalitis (HP:0002383)2.30268854
94Broad face (HP:0000283)2.29405406
95Thick nail (HP:0001805)2.29122120
96Hypochromic anemia (HP:0001931)2.27898348
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27769857
98Increased serum ferritin (HP:0003281)2.24098808
99Sepsis (HP:0100806)2.24080837
100Pterygium (HP:0001059)2.23304029
101Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23096506
102Epistaxis (HP:0000421)2.20228666
103Cheilitis (HP:0100825)2.18951530
104Alopecia of scalp (HP:0002293)2.17443596
105Epidermoid cyst (HP:0200040)2.17421536
106Vasculitis (HP:0002633)2.16653067
107Granulocytopenia (HP:0001913)2.16575318
108Prolonged partial thromboplastin time (HP:0003645)2.15902389
109Popliteal pterygium (HP:0009756)2.15796549
110Corneal erosion (HP:0200020)2.12678928
111Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11931421
112Spontaneous hematomas (HP:0007420)2.10725466
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10052604
114Abnormality of lateral ventricle (HP:0030047)2.09595461
115Hypoplastic labia majora (HP:0000059)2.09221138
116Increased cerebral lipofuscin (HP:0011813)2.09109013
117Agammaglobulinemia (HP:0004432)2.06550681
118Hypercholesterolemia (HP:0003124)2.04854040
119Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03227536
120Verrucae (HP:0200043)2.02439417
121Papilloma (HP:0012740)2.02439417
122Ridged nail (HP:0001807)2.01149679
123Fragile skin (HP:0001030)1.99844704
124Stomatitis (HP:0010280)1.99173588
125Conjugated hyperbilirubinemia (HP:0002908)1.98129767
126Deep venous thrombosis (HP:0002625)1.97038840
127Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.95946882
128Fat malabsorption (HP:0002630)1.95119624
129Hemoptysis (HP:0002105)1.93997175
130Arterial thrombosis (HP:0004420)1.93734714
131Ventricular tachycardia (HP:0004756)1.93177444
132Hypergammaglobulinemia (HP:0010702)1.92211692
133Chest pain (HP:0100749)1.91964553
134Increased neuronal autofluorescent lipopigment (HP:0002074)1.91766110
135Concave nail (HP:0001598)1.91534214
136Hyporeflexia of lower limbs (HP:0002600)1.89394638
137Hypertriglyceridemia (HP:0002155)1.88110132
138Abnormality of T cell physiology (HP:0011840)1.87921390
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.87420504
140Urticaria (HP:0001025)1.87289980
141Abnormality of the labia majora (HP:0012881)1.86843282
142Subacute progressive viral hepatitis (HP:0006572)1.85735127
143Hyperlipoproteinemia (HP:0010980)1.85629246
144Dehydration (HP:0001944)1.84518700
145Hyperglycinuria (HP:0003108)1.83543394
146Osteomyelitis (HP:0002754)1.82530659
147Gingival bleeding (HP:0000225)1.82529883
148Pustule (HP:0200039)1.81353996
149Polygenic inheritance (HP:0010982)1.80472588
150Dysostosis multiplex (HP:0000943)1.80412284
151Curly hair (HP:0002212)1.79896609
152Fatigue (HP:0012378)1.79305867
153Slow saccadic eye movements (HP:0000514)1.79302591
154Poikilocytosis (HP:0004447)1.79032488
155Petechiae (HP:0000967)1.78709295
156Abnormality of iron homeostasis (HP:0011031)1.78330286
157Thin bony cortex (HP:0002753)1.78138293
158Bronchomalacia (HP:0002780)1.77759006
159Increased connective tissue (HP:0009025)1.77739668
160Abnormality of the peritoneum (HP:0002585)1.77326542
161Increased mean platelet volume (HP:0011877)1.77146715
162Abnormality of the columella (HP:0009929)1.76985221
163Abnormality of pyrimidine metabolism (HP:0004353)1.76789119
164Abnormality of T cells (HP:0002843)1.76665283
165Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76498562
166Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76424697
167Sex reversal (HP:0012245)1.74684320
168Abnormal sex determination (HP:0012244)1.74684320
169Oral leukoplakia (HP:0002745)1.74551676
170Syringomyelia (HP:0003396)1.74239139
171Spinal cord lesions (HP:0100561)1.74239139
172Pulmonary infiltrates (HP:0002113)1.74131875
173Segmental peripheral demyelination/remyelination (HP:0003481)1.73764005
174Loss of speech (HP:0002371)1.69324200
175Leukocytosis (HP:0001974)1.68968586
176T lymphocytopenia (HP:0005403)1.66872158
177Flat acetabular roof (HP:0003180)1.66671310
178Ectropion (HP:0000656)1.63772648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.53681445
2ERN13.95022684
3MAP3K33.89440480
4PRPF4B3.63283155
5MAPKAPK33.33314506
6TRIB33.13848219
7MAP2K33.13752145
8MET2.82251116
9CDK122.78482597
10LATS12.72512215
11PIM22.70150170
12RPS6KB22.60716534
13MAP3K22.58991878
14MST42.55572207
15LRRK22.35384027
16SMG12.33659690
17EEF2K2.11093912
18MAP3K132.08819916
19IRAK42.05589509
20EPHA21.89689027
21TRPM71.73881064
22JAK31.73689272
23RIPK11.66405716
24MAP3K101.58960411
25ZAP701.56857198
26MAP3K71.56791218
27CDK61.48193143
28MAPK111.45569064
29FER1.43746549
30FES1.41772386
31IRAK31.39435699
32MAP3K61.38112078
33TYK21.37309612
34CSK1.37176360
35TBK11.36747447
36STK101.32832083
37DYRK1B1.32197788
38TGFBR11.27504108
39PASK1.17494962
40EPHB21.17069892
41TNK21.16564738
42RIPK41.14468504
43BTK1.13424755
44STK241.13380616
45PKN21.07866472
46SYK1.04688044
47FGFR21.04674420
48TXK1.03562388
49CDK41.02868733
50FRK1.02502607
51JAK11.01397186
52SIK21.00119647
53FGFR40.98492529
54SIK10.98270963
55GRK60.97596623
56IRAK20.97203379
57CSF1R0.96119778
58CDK190.95433513
59PTK60.94972075
60PRKCI0.92207016
61MAPK120.91866759
62FGFR30.90530578
63TESK10.88051252
64IKBKB0.87717190
65RPS6KL10.85462001
66RPS6KC10.85462001
67TAOK20.83853147
68FGR0.83740452
69TESK20.82464699
70PRKD20.82366605
71MAPK70.81108265
72TLK10.80691472
73IRAK10.80569430
74LCK0.80225365
75BMX0.79986382
76NME20.79876563
77MTOR0.79050649
78MAP3K140.78721641
79KSR20.76796457
80ERBB40.76582517
81ERBB30.76075761
82BLK0.74514325
83BRD40.73237173
84CDC42BPA0.73040117
85MARK30.71728593
86SIK30.71699453
87MAP2K20.71468543
88ACVR1B0.69994099
89CAMK1D0.69775539
90RPS6KA60.69763089
91LYN0.69578499
92ERBB20.69558471
93IKBKE0.66605528
94PDPK10.66324423
95MAPK40.65567806
96PTK20.63089833
97MAP3K110.62873105
98TGFBR20.62619515
99PDK10.61516681
100MATK0.60411160
101SCYL20.59626782
102KDR0.58810188
103RET0.58319825
104MAPKAPK20.58116618
105NME10.54579693
106PIK3CG0.54353496
107RPS6KA20.54096798
108PRKG20.53851452
109HIPK20.53422327
110MAPK150.52215145
111CDK70.50878214
112TEC0.49650199
113JAK20.48574938
114ILK0.47038194
115MELK0.46605003
116MARK20.46139754
117NEK90.45797420
118TAOK10.44801724
119SGK30.44198899
120BMPR20.42896563
121MAP2K40.42112111
122ITK0.41514732
123TTN0.41482832
124GRK10.41392569
125MAPK30.39889543
126PAK20.38968790
127PIM10.38271668
128ABL20.38188415
129MAP3K80.36346429
130MUSK0.36218143
131STK110.36012875
132MAP3K10.35106087
133ABL10.34579788
134RPS6KA10.34026591
135MAP2K60.33876766
136DAPK30.33766733
137AURKB0.33140797
138ICK0.32058285
139AKT20.30254643
140EPHB10.29920034
141MAP2K10.29491631
142TAOK30.29166562
143MAP4K10.28955397
144KIT0.28323489
145HCK0.25587900
146BCKDK0.24794247
147CSNK1D0.24245511
148LATS20.23277248
149SRC0.23255613
150MAP3K90.22976533
151BCR0.22004429

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.17241082
2Ribosome_Homo sapiens_hsa030104.47786535
3Caffeine metabolism_Homo sapiens_hsa002323.25546344
4Fat digestion and absorption_Homo sapiens_hsa049753.10429330
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.92132853
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.75646853
7Folate biosynthesis_Homo sapiens_hsa007902.53765825
8B cell receptor signaling pathway_Homo sapiens_hsa046622.43482421
9Acute myeloid leukemia_Homo sapiens_hsa052212.33374450
10Leishmaniasis_Homo sapiens_hsa051402.32515417
11Osteoclast differentiation_Homo sapiens_hsa043802.30276701
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28998041
13Fatty acid elongation_Homo sapiens_hsa000622.23796556
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18327802
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.15483307
16Vitamin digestion and absorption_Homo sapiens_hsa049772.10385791
17Histidine metabolism_Homo sapiens_hsa003402.09921344
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09176636
19Other glycan degradation_Homo sapiens_hsa005112.08611221
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04760615
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92145624
22Renin-angiotensin system_Homo sapiens_hsa046141.91151908
23Arginine biosynthesis_Homo sapiens_hsa002201.90087500
24Retinol metabolism_Homo sapiens_hsa008301.89005891
25Non-small cell lung cancer_Homo sapiens_hsa052231.88383575
26Chemical carcinogenesis_Homo sapiens_hsa052041.87496877
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81829588
28Chronic myeloid leukemia_Homo sapiens_hsa052201.76326687
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76011334
30T cell receptor signaling pathway_Homo sapiens_hsa046601.73547440
31Primary immunodeficiency_Homo sapiens_hsa053401.73385140
32VEGF signaling pathway_Homo sapiens_hsa043701.70983281
33Mineral absorption_Homo sapiens_hsa049781.65117923
34Fatty acid degradation_Homo sapiens_hsa000711.64945684
35Glutathione metabolism_Homo sapiens_hsa004801.60283383
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59144333
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.58333420
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58270867
39Pancreatic cancer_Homo sapiens_hsa052121.57929628
40Tuberculosis_Homo sapiens_hsa051521.56799120
41Tryptophan metabolism_Homo sapiens_hsa003801.55584899
42Starch and sucrose metabolism_Homo sapiens_hsa005001.55233240
43Measles_Homo sapiens_hsa051621.52755342
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.50070435
45Graft-versus-host disease_Homo sapiens_hsa053321.48623819
46Influenza A_Homo sapiens_hsa051641.47282688
47Nitrogen metabolism_Homo sapiens_hsa009101.45523825
48Toxoplasmosis_Homo sapiens_hsa051451.44881268
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44646948
50Herpes simplex infection_Homo sapiens_hsa051681.44468523
51PPAR signaling pathway_Homo sapiens_hsa033201.43017829
52Phenylalanine metabolism_Homo sapiens_hsa003601.40724825
53TNF signaling pathway_Homo sapiens_hsa046681.38122665
54Bile secretion_Homo sapiens_hsa049761.36864420
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36351917
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35633353
57Hepatitis B_Homo sapiens_hsa051611.31326893
58Complement and coagulation cascades_Homo sapiens_hsa046101.24747997
59Malaria_Homo sapiens_hsa051441.23983664
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.23858042
61Galactose metabolism_Homo sapiens_hsa000521.18707580
62Sphingolipid metabolism_Homo sapiens_hsa006001.18170294
63Protein digestion and absorption_Homo sapiens_hsa049741.17309703
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.16889435
65Platelet activation_Homo sapiens_hsa046111.15261843
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15248572
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15172609
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14599868
69Allograft rejection_Homo sapiens_hsa053301.14552362
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13322793
71Steroid hormone biosynthesis_Homo sapiens_hsa001401.13268885
72Renal cell carcinoma_Homo sapiens_hsa052111.11401804
73Peroxisome_Homo sapiens_hsa041461.11008448
74GnRH signaling pathway_Homo sapiens_hsa049121.10014796
75Hematopoietic cell lineage_Homo sapiens_hsa046401.09843488
76Apoptosis_Homo sapiens_hsa042101.08512563
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07402405
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07072978
79beta-Alanine metabolism_Homo sapiens_hsa004101.06373206
80Autoimmune thyroid disease_Homo sapiens_hsa053201.05948529
81Chemokine signaling pathway_Homo sapiens_hsa040621.05900545
82Glycosaminoglycan degradation_Homo sapiens_hsa005311.04389164
83Shigellosis_Homo sapiens_hsa051311.03897682
84Choline metabolism in cancer_Homo sapiens_hsa052311.03804239
85Prolactin signaling pathway_Homo sapiens_hsa049171.03262686
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02312762
87p53 signaling pathway_Homo sapiens_hsa041151.02273513
88Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01118913
89Antigen processing and presentation_Homo sapiens_hsa046120.99994322
90ABC transporters_Homo sapiens_hsa020100.98363341
91mTOR signaling pathway_Homo sapiens_hsa041500.97506761
92Viral carcinogenesis_Homo sapiens_hsa052030.96799383
93Endometrial cancer_Homo sapiens_hsa052130.94881696
94Basal cell carcinoma_Homo sapiens_hsa052170.94846101
95HTLV-I infection_Homo sapiens_hsa051660.93144406
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91895850
97Viral myocarditis_Homo sapiens_hsa054160.90275788
98Inositol phosphate metabolism_Homo sapiens_hsa005620.89192577
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.89085302
100Staphylococcus aureus infection_Homo sapiens_hsa051500.88311572
101Colorectal cancer_Homo sapiens_hsa052100.86520080
102Small cell lung cancer_Homo sapiens_hsa052220.86470037
103Epstein-Barr virus infection_Homo sapiens_hsa051690.85834979
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.85183433
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85069472
106Fatty acid metabolism_Homo sapiens_hsa012120.84709884
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84080860
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.82719280
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82566322
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82248124
111ErbB signaling pathway_Homo sapiens_hsa040120.81290890
112Bladder cancer_Homo sapiens_hsa052190.80858116
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.80242480
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77757424
115Tyrosine metabolism_Homo sapiens_hsa003500.76940094
116Sulfur metabolism_Homo sapiens_hsa009200.76654721
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76642539
118FoxO signaling pathway_Homo sapiens_hsa040680.75905506
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75171347
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74163830
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.73587927
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73458396
123Glioma_Homo sapiens_hsa052140.72351620
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.72017318
125Prostate cancer_Homo sapiens_hsa052150.69212746
126Insulin signaling pathway_Homo sapiens_hsa049100.69148066
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68204966
128Linoleic acid metabolism_Homo sapiens_hsa005910.67955110
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67919815
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67871251
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66754890
132Lysosome_Homo sapiens_hsa041420.66336366
133Biosynthesis of amino acids_Homo sapiens_hsa012300.65447058
134MicroRNAs in cancer_Homo sapiens_hsa052060.64679337
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.64515350
136Selenocompound metabolism_Homo sapiens_hsa004500.62346364
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61746417
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60095565
139Dorso-ventral axis formation_Homo sapiens_hsa043200.59535267
140Amoebiasis_Homo sapiens_hsa051460.59282630
141Endocytosis_Homo sapiens_hsa041440.59009766
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58498779
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58452150
144Pentose phosphate pathway_Homo sapiens_hsa000300.58405737
145MAPK signaling pathway_Homo sapiens_hsa040100.58390753
146Type I diabetes mellitus_Homo sapiens_hsa049400.57560142
147HIF-1 signaling pathway_Homo sapiens_hsa040660.56526815
148Arginine and proline metabolism_Homo sapiens_hsa003300.55420427
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54884324
150Lysine degradation_Homo sapiens_hsa003100.54440978
151Phagosome_Homo sapiens_hsa041450.51000850
152Butanoate metabolism_Homo sapiens_hsa006500.50413574
153Arachidonic acid metabolism_Homo sapiens_hsa005900.50226517
154TGF-beta signaling pathway_Homo sapiens_hsa043500.47840076
155Estrogen signaling pathway_Homo sapiens_hsa049150.46831593
156Fatty acid biosynthesis_Homo sapiens_hsa000610.46277080
157Glycerolipid metabolism_Homo sapiens_hsa005610.41578364
158Carbon metabolism_Homo sapiens_hsa012000.41383126
159Legionellosis_Homo sapiens_hsa051340.41159074
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40953398
161Tight junction_Homo sapiens_hsa045300.35528096
162Hippo signaling pathway_Homo sapiens_hsa043900.35330729
163ECM-receptor interaction_Homo sapiens_hsa045120.34682626
164Steroid biosynthesis_Homo sapiens_hsa001000.33719210
165Fructose and mannose metabolism_Homo sapiens_hsa000510.31513635
166Thyroid cancer_Homo sapiens_hsa052160.31435761
167Notch signaling pathway_Homo sapiens_hsa043300.31401635
168Hepatitis C_Homo sapiens_hsa051600.30430526
169Metabolic pathways_Homo sapiens_hsa011000.29667739
170Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29298133
171Sulfur relay system_Homo sapiens_hsa041220.25895871
172Cysteine and methionine metabolism_Homo sapiens_hsa002700.23574334
173African trypanosomiasis_Homo sapiens_hsa051430.18673769
174Insulin resistance_Homo sapiens_hsa049310.18662950
175Pertussis_Homo sapiens_hsa051330.17550282
176Adherens junction_Homo sapiens_hsa045200.17493448
177Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17449493
178One carbon pool by folate_Homo sapiens_hsa006700.16711041
179Leukocyte transendothelial migration_Homo sapiens_hsa046700.16633330
180Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16106883
181Hedgehog signaling pathway_Homo sapiens_hsa043400.15647290
182Salmonella infection_Homo sapiens_hsa051320.13641701

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