LTBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.51321880
2negative regulation of fatty acid transport (GO:2000192)4.66508651
3collagen fibril organization (GO:0030199)4.55440439
4endothelial cell chemotaxis (GO:0035767)4.40840200
5hemidesmosome assembly (GO:0031581)4.35593373
6sequestering of extracellular ligand from receptor (GO:0035581)4.00658763
7endodermal cell differentiation (GO:0035987)3.96222320
8semaphorin-plexin signaling pathway (GO:0071526)3.92741619
9plasma membrane repair (GO:0001778)3.89598380
10regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.88411025
11skin morphogenesis (GO:0043589)3.85469262
12collagen metabolic process (GO:0032963)3.66633419
13chondrocyte proliferation (GO:0035988)3.63588811
14cell-substrate junction assembly (GO:0007044)3.62809539
15bone trabecula formation (GO:0060346)3.55210317
16collagen catabolic process (GO:0030574)3.53930860
17cellular response to vitamin (GO:0071295)3.51641373
18multicellular organismal macromolecule metabolic process (GO:0044259)3.50854322
19regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.43149091
20basement membrane organization (GO:0071711)3.41189180
21mannose metabolic process (GO:0006013)3.37695931
22peptidyl-proline hydroxylation (GO:0019511)3.37550814
23multicellular organismal metabolic process (GO:0044236)3.34431028
24apoptotic cell clearance (GO:0043277)3.34172003
25negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.31233774
26cell adhesion mediated by integrin (GO:0033627)3.29438506
27multicellular organismal catabolic process (GO:0044243)3.29031485
28epithelial cell-cell adhesion (GO:0090136)3.27741428
29COPI coating of Golgi vesicle (GO:0048205)3.27348748
30Golgi transport vesicle coating (GO:0048200)3.27348748
31extracellular matrix disassembly (GO:0022617)3.25440263
32positive regulation of endothelial cell apoptotic process (GO:2000353)3.25063479
33regulation of extracellular matrix disassembly (GO:0010715)3.21711967
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.18693728
35axon extension involved in axon guidance (GO:0048846)3.18693728
36mesenchymal-epithelial cell signaling (GO:0060638)3.18195354
37negative regulation of smooth muscle cell migration (GO:0014912)3.12308120
38glomerular basement membrane development (GO:0032836)3.07024189
39stress fiber assembly (GO:0043149)3.04103137
40pattern specification involved in kidney development (GO:0061004)2.99899244
41dermatan sulfate metabolic process (GO:0030205)2.99136122
42adherens junction assembly (GO:0034333)2.97031286
43renal filtration (GO:0097205)2.96477904
44atrioventricular valve morphogenesis (GO:0003181)2.96426051
45insulin-like growth factor receptor signaling pathway (GO:0048009)2.95609641
46retina vasculature morphogenesis in camera-type eye (GO:0061299)2.92998535
47protein hydroxylation (GO:0018126)2.92050538
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.91419216
49cell volume homeostasis (GO:0006884)2.88041618
50positive regulation of histone deacetylation (GO:0031065)2.87454103
51outer ear morphogenesis (GO:0042473)2.85993762
52planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83820388
53positive regulation of receptor recycling (GO:0001921)2.82760405
54vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.82422174
55positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.81292057
56gland morphogenesis (GO:0022612)2.79603617
57branching involved in salivary gland morphogenesis (GO:0060445)2.75827785
58vascular endothelial growth factor signaling pathway (GO:0038084)2.75233749
59chondroitin sulfate catabolic process (GO:0030207)2.75119073
60focal adhesion assembly (GO:0048041)2.74612751
61cell-substrate adherens junction assembly (GO:0007045)2.74612751
62negative regulation of cell size (GO:0045792)2.74025158
63positive regulation of osteoblast proliferation (GO:0033690)2.73986666
64protein localization to cell surface (GO:0034394)2.73534258
65venous blood vessel morphogenesis (GO:0048845)2.73383184
66barbed-end actin filament capping (GO:0051016)2.73090395
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72394023
68endothelial cell morphogenesis (GO:0001886)2.71998094
69negative regulation of osteoblast proliferation (GO:0033689)2.71875937
70positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.71624317
71cellular response to interferon-alpha (GO:0035457)2.69819479
72cell-cell junction maintenance (GO:0045217)2.69604630
73peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.69564684
74hippo signaling (GO:0035329)2.68369139
75regulation of glucose import in response to insulin stimulus (GO:2001273)2.66590889
76negative regulation of catenin import into nucleus (GO:0035414)2.66345462
77cell migration involved in heart development (GO:0060973)2.66025686
78low-density lipoprotein particle clearance (GO:0034383)2.65507789
79cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.65180624
80cellular response to vitamin D (GO:0071305)2.64999413
81regulation of osteoblast proliferation (GO:0033688)2.64921155
82metanephric mesenchyme development (GO:0072075)2.64148845
83positive regulation of myotube differentiation (GO:0010831)2.58211438
84regulation of endothelial cell chemotaxis (GO:2001026)2.57971673
85polarized epithelial cell differentiation (GO:0030859)2.57085240
86growth hormone receptor signaling pathway (GO:0060396)2.56903006
87regulation of p38MAPK cascade (GO:1900744)2.55511347
88glomerular filtration (GO:0003094)2.54744555
89cellular response to growth hormone stimulus (GO:0071378)2.53260875
90regulation of ARF GTPase activity (GO:0032312)2.52416388
91mesodermal cell differentiation (GO:0048333)2.52031094
92positive regulation of p38MAPK cascade (GO:1900745)2.51960841
93white fat cell differentiation (GO:0050872)2.51899871
94keratan sulfate catabolic process (GO:0042340)2.48289304
95extracellular matrix assembly (GO:0085029)2.47997570
96cell migration involved in sprouting angiogenesis (GO:0002042)2.47394404
97dermatan sulfate biosynthetic process (GO:0030208)2.45346208
98* extracellular matrix organization (GO:0030198)2.45252955
99regulation of protein heterodimerization activity (GO:0043497)2.44729856
100negative regulation of erythrocyte differentiation (GO:0045647)2.44644978
101* extracellular structure organization (GO:0043062)2.43936119
102kidney mesenchyme development (GO:0072074)2.43714436
103substrate adhesion-dependent cell spreading (GO:0034446)2.42630258
104apoptotic process involved in morphogenesis (GO:0060561)2.42520035
105extracellular fibril organization (GO:0043206)2.41813944
106positive regulation of glycogen biosynthetic process (GO:0045725)2.41361559
107adhesion of symbiont to host cell (GO:0044650)2.40710789
108virion attachment to host cell (GO:0019062)2.40710789
109positive regulation of mesenchymal cell proliferation (GO:0002053)2.40594462
110regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.40449564
111adhesion of symbiont to host (GO:0044406)2.40396231
112metanephric nephron epithelium development (GO:0072243)2.40345282
113lung epithelium development (GO:0060428)2.39389126
114wound healing, spreading of epidermal cells (GO:0035313)2.37672740
115G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.36677828
116protein targeting to plasma membrane (GO:0072661)2.36288298
117camera-type eye morphogenesis (GO:0048593)2.35738389
118negative regulation of anoikis (GO:2000811)2.35210415
119regulation of tight junction assembly (GO:2000810)2.34790105
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34749313
121regulation of fatty acid beta-oxidation (GO:0031998)2.33663429
122synaptic vesicle docking involved in exocytosis (GO:0016081)2.32797038
123craniofacial suture morphogenesis (GO:0097094)2.32449163
124endocardial cushion development (GO:0003197)2.32230040
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32112889
126regulation of extracellular matrix organization (GO:1903053)2.31850886
127lung vasculature development (GO:0060426)2.31489400
128cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.31080935
129ear development (GO:0043583)2.30559494
130positive regulation of extracellular matrix organization (GO:1903055)2.30466674
131retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.30201060
132positive regulation of fatty acid beta-oxidation (GO:0032000)2.29894648
133neural tube development (GO:0021915)2.29708932
134regulation of axon extension involved in axon guidance (GO:0048841)2.29443448
135positive regulation of protein kinase C signaling (GO:0090037)2.29081707
136* negative regulation of chondrocyte differentiation (GO:0032331)2.28951817
137muscle cell migration (GO:0014812)2.28852729
138regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.28515988
139protein retention in ER lumen (GO:0006621)2.28178713
140anatomical structure regression (GO:0060033)2.27450366
141metanephric tubule development (GO:0072170)2.25825188
142metanephric nephron tubule development (GO:0072234)2.25825188
143activation of Rac GTPase activity (GO:0032863)2.22813919
144fibril organization (GO:0097435)2.21848248
145desmosome organization (GO:0002934)2.21181080
146chondroitin sulfate biosynthetic process (GO:0030206)2.20040391
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.18987219
148heart valve morphogenesis (GO:0003179)2.17844992
149type B pancreatic cell proliferation (GO:0044342)2.16658916
150metanephric epithelium development (GO:0072207)2.15326540
151dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.14860803
152endocytic recycling (GO:0032456)2.13945527
153activation of JUN kinase activity (GO:0007257)2.11773871
154response to fluid shear stress (GO:0034405)2.11511519
155eye morphogenesis (GO:0048592)2.11321399
156surfactant homeostasis (GO:0043129)2.11049356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.56118886
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.23337265
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.67593906
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07094936
5CLOCK_20551151_ChIP-Seq_293T_Human2.90617386
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.34127953
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33135483
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.29584666
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.18807509
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.18419002
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.13941852
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10626740
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05271643
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95603396
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.91375209
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91325913
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85054196
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83304841
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83304841
20ZNF263_19887448_ChIP-Seq_K562_Human1.79911003
21* TCF7_22412390_ChIP-Seq_EML_Mouse1.79124294
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.78094890
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72338042
24CJUN_26792858_Chip-Seq_BT549_Human1.71693261
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70447973
26SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69447312
27* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66714966
28* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66629165
29* ELK3_25401928_ChIP-Seq_HUVEC_Human1.64436769
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64048451
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.63663678
32KDM2B_26808549_Chip-Seq_K562_Human1.60482466
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59156886
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57543152
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56695627
36* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55282838
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54906208
38VDR_21846776_ChIP-Seq_THP-1_Human1.53883629
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.51091498
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48504678
41* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47389327
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46182182
43* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44829398
44* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44306685
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44283976
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.44037115
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.44037115
48* SMC4_20622854_ChIP-Seq_HELA_Human1.43559362
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42932376
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42692432
51* RACK7_27058665_Chip-Seq_MCF-7_Human1.41983740
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39488850
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.37336319
54LXR_22292898_ChIP-Seq_THP-1_Human1.36371733
55* CTCF_27219007_Chip-Seq_Bcells_Human1.35304667
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34031630
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33679416
58BRD4_25478319_ChIP-Seq_HGPS_Human1.33089764
59* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31940880
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31314364
61P68_20966046_ChIP-Seq_HELA_Human1.30911693
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30531322
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30460619
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30460619
65* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30096478
66AHR_22903824_ChIP-Seq_MCF-7_Human1.29997593
67SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29624301
68SOX2_20726797_ChIP-Seq_SW620_Human1.29583210
69TP53_22127205_ChIP-Seq_IMR90_Human1.29308113
70* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29071120
71* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29071120
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29060598
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.28560843
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27870109
75CREB1_26743006_Chip-Seq_LNCaP_Human1.27847930
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27408690
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.24526671
78* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23797450
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23087438
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22554316
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21853589
82AR_21572438_ChIP-Seq_LNCaP_Human1.20326692
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20242613
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.19777606
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19489722
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18583473
87* TET1_21451524_ChIP-Seq_MESCs_Mouse1.18306408
88* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18024049
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.17413656
90* UBF1/2_26484160_Chip-Seq_HMECs_Human1.17044952
91* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16566155
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16112340
93* KDM2B_26808549_Chip-Seq_DND41_Human1.16001527
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15547199
95* EZH2_27294783_Chip-Seq_ESCs_Mouse1.15365198
96* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14012098
97RXR_22108803_ChIP-Seq_LS180_Human1.13915726
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.13085819
99TP63_22573176_ChIP-Seq_HFKS_Human1.12716329
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12578231
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.11740506
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.11693572
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11201269
104* KDM2B_26808549_Chip-Seq_JURKAT_Human1.11051526
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10676779
106EGR1_19374776_ChIP-ChIP_THP-1_Human1.10329085
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.10200452
108* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09960371
109SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09896424
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09352985
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09183099
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08347919
113MYC_22102868_ChIP-Seq_BL_Human1.07707812
114* ATF3_27146783_Chip-Seq_COLON_Human1.06695946
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06038834
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03940037
117* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03844521
118JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03576210
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03442708
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02525127
121* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01705472
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01632847
123DROSHA_22980978_ChIP-Seq_HELA_Human1.01564244
124TP53_23651856_ChIP-Seq_MEFs_Mouse1.01427721
125CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01291606
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.01175045
127KLF5_25053715_ChIP-Seq_YYC3_Human1.00367605
128* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00357825
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00123387
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99800477
131* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99571984
132* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99569131
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98220700
134* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97534771
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93741469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.72128299
2MP0005275_abnormal_skin_tensile4.76961443
3MP0005503_abnormal_tendon_morphology3.85152566
4MP0003705_abnormal_hypodermis_morpholog3.67103762
5MP0004272_abnormal_basement_membrane3.05738372
6MP0005623_abnormal_meninges_morphology2.96718331
7MP0001958_emphysema2.85314950
8MP0003279_aneurysm2.81748029
9MP0000013_abnormal_adipose_tissue2.16427771
10MP0003566_abnormal_cell_adhesion2.13630367
11MP0000751_myopathy2.07729802
12MP0002060_abnormal_skin_morphology2.01428720
13MP0005257_abnormal_intraocular_pressure1.95224527
14MP0005409_darkened_coat_color1.94086208
15MP0006054_spinal_hemorrhage1.85873565
16MP0005508_abnormal_skeleton_morphology1.85010370
17MP0005670_abnormal_white_adipose1.81717738
18MP0009384_cardiac_valve_regurgitation1.79683216
19MP0000733_abnormal_muscle_development1.76422816
20MP0003045_fibrosis1.75756587
21MP0000003_abnormal_adipose_tissue1.72995995
22MP0005058_abnormal_lysosome_morphology1.72675225
23MP0002896_abnormal_bone_mineralization1.65556823
24MP0002168_other_aberrant_phenotype1.62258183
25MP0005375_adipose_tissue_phenotype1.60071299
26MP0000750_abnormal_muscle_regeneration1.59742142
27MP0002108_abnormal_muscle_morphology1.59720808
28MP0005023_abnormal_wound_healing1.58078535
29MP0003091_abnormal_cell_migration1.56043625
30MP0001849_ear_inflammation1.52114446
31MP0003942_abnormal_urinary_system1.51116668
32MP0005666_abnormal_adipose_tissue1.48391651
33MP0003283_abnormal_digestive_organ1.47967758
34MP0000534_abnormal_ureter_morphology1.47780921
35MP0004858_abnormal_nervous_system1.45531316
36MP0004130_abnormal_muscle_cell1.44990164
37MP0010030_abnormal_orbit_morphology1.44913818
38MP0002295_abnormal_pulmonary_circulatio1.44200152
39MP0000678_abnormal_parathyroid_gland1.43814944
40MP0009250_abnormal_appendicular_skeleto1.42704928
41MP0003172_abnormal_lysosome_physiology1.39925581
42MP0002877_abnormal_melanocyte_morpholog1.39657288
43MP0004185_abnormal_adipocyte_glucose1.39178746
44MP0004145_abnormal_muscle_electrophysio1.38474181
45MP0001299_abnormal_eye_distance/1.35740263
46MP0003385_abnormal_body_wall1.34030048
47MP0002234_abnormal_pharynx_morphology1.28114296
48MP0005595_abnormal_vascular_smooth1.27317626
49MP0002837_dystrophic_cardiac_calcinosis1.26669893
50MP0009780_abnormal_chondrocyte_physiolo1.23994314
51MP0004087_abnormal_muscle_fiber1.20083455
52MP0000759_abnormal_skeletal_muscle1.19690418
53* MP0002933_joint_inflammation1.19542947
54MP0010234_abnormal_vibrissa_follicle1.18904715
55MP0003300_gastrointestinal_ulcer1.18305954
56MP0004084_abnormal_cardiac_muscle1.18235076
57MP0000767_abnormal_smooth_muscle1.16173436
58MP0003329_amyloid_beta_deposits1.14749439
59* MP0000163_abnormal_cartilage_morphology1.11052335
60MP0000537_abnormal_urethra_morphology1.10927363
61MP0004859_abnormal_synaptic_plasticity1.08567236
62MP0005076_abnormal_cell_differentiation1.08104396
63MP0004036_abnormal_muscle_relaxation1.06885184
64MP0002249_abnormal_larynx_morphology1.06384437
65MP0003879_abnormal_hair_cell1.05593158
66MP0000467_abnormal_esophagus_morphology1.05541816
67MP0010352_gastrointestinal_tract_polyps1.04615836
68MP0003115_abnormal_respiratory_system1.04377181
69MP0006138_congestive_heart_failure1.04273552
70MP0010368_abnormal_lymphatic_system1.02643319
71* MP0002115_abnormal_skeleton_extremities1.01611031
72MP0001502_abnormal_circadian_rhythm1.01197262
73MP0000749_muscle_degeneration1.00717278
74MP0001243_abnormal_dermal_layer0.98269739
75MP0005451_abnormal_body_composition0.97898158
76* MP0000428_abnormal_craniofacial_morphol0.94743760
77MP0000566_synostosis0.92982392
78MP0002909_abnormal_adrenal_gland0.92349795
79MP0005390_skeleton_phenotype0.92111545
80MP0004510_myositis0.91074902
81MP0002282_abnormal_trachea_morphology0.90384907
82MP0005369_muscle_phenotype0.90169710
83MP0000049_abnormal_middle_ear0.89274801
84MP0003634_abnormal_glial_cell0.88883503
85MP0000747_muscle_weakness0.88766655
86MP0008260_abnormal_autophagy0.88438098
87MP0004134_abnormal_chest_morphology0.87820823
88MP0001879_abnormal_lymphatic_vessel0.85247566
89MP0000249_abnormal_blood_vessel0.83979232
90MP0000762_abnormal_tongue_morphology0.83177386
91MP0001542_abnormal_bone_strength0.83075099
92MP0002089_abnormal_postnatal_growth/wei0.82308501
93MP0010630_abnormal_cardiac_muscle0.81001125
94MP0009840_abnormal_foam_cell0.80470628
95MP0002177_abnormal_outer_ear0.80391548
96MP0003191_abnormal_cellular_cholesterol0.78883961
97* MP0002998_abnormal_bone_remodeling0.78862262
98MP0003755_abnormal_palate_morphology0.78787844
99MP0002106_abnormal_muscle_physiology0.77567866
100MP0000681_abnormal_thyroid_gland0.77139222
101* MP0002932_abnormal_joint_morphology0.76984517
102MP0001614_abnormal_blood_vessel0.76832326
103* MP0002113_abnormal_skeleton_development0.76736183
104MP0003690_abnormal_glial_cell0.76438399
105MP0002233_abnormal_nose_morphology0.75779830
106MP0000462_abnormal_digestive_system0.74753243
107MP0002128_abnormal_blood_circulation0.73990810
108MP0000579_abnormal_nail_morphology0.72558880
109MP0001270_distended_abdomen0.72368629
110MP0002796_impaired_skin_barrier0.72195236
111MP0005164_abnormal_response_to0.71922870
112MP0005330_cardiomyopathy0.70846246
113MP0003935_abnormal_craniofacial_develop0.70702706
114MP0003453_abnormal_keratinocyte_physiol0.70397118
115MP0000538_abnormal_urinary_bladder0.69587712
116MP0005171_absent_coat_pigmentation0.69426100
117MP0002269_muscular_atrophy0.69235124
118MP0002925_abnormal_cardiovascular_devel0.68432999
119MP0009278_abnormal_bone_marrow0.68053988
120MP0009115_abnormal_fat_cell0.68038491
121MP0001544_abnormal_cardiovascular_syste0.67443785
122MP0005385_cardiovascular_system_phenoty0.67443785
123* MP0000432_abnormal_head_morphology0.67441201
124MP0010771_integument_phenotype0.67118751
125MP0002133_abnormal_respiratory_system0.67074229
126MP0005388_respiratory_system_phenotype0.67074229
127* MP0002116_abnormal_craniofacial_bone0.66923074
128MP0002254_reproductive_system_inflammat0.66788273

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.01676618
2Premature rupture of membranes (HP:0001788)6.23678255
3Ankle contracture (HP:0006466)5.14612727
4Atrophic scars (HP:0001075)4.93812864
5Shallow orbits (HP:0000586)4.84733075
6Obstructive sleep apnea (HP:0002870)4.63650549
7Broad metatarsal (HP:0001783)4.55131516
8Fragile skin (HP:0001030)4.09526063
9Type 1 muscle fiber predominance (HP:0003803)3.99116458
10Cerebral aneurysm (HP:0004944)3.95787476
11Aortic dissection (HP:0002647)3.88267142
12Increased connective tissue (HP:0009025)3.60497146
13Broad face (HP:0000283)3.55286423
14Spinal rigidity (HP:0003306)3.45657191
15Bladder diverticulum (HP:0000015)3.35310906
16Soft skin (HP:0000977)3.34861371
17Follicular hyperkeratosis (HP:0007502)3.23666057
18Peritonitis (HP:0002586)3.23091620
19Cervical subluxation (HP:0003308)3.10892712
20Increased variability in muscle fiber diameter (HP:0003557)3.10407351
21Mildly elevated creatine phosphokinase (HP:0008180)3.08882127
22Vertebral compression fractures (HP:0002953)3.04017056
23Neonatal short-limb short stature (HP:0008921)3.03970006
24Aortic aneurysm (HP:0004942)3.00943551
25Dilatation of the ascending aorta (HP:0005111)2.95727720
26Blue sclerae (HP:0000592)2.88822658
27Hyperacusis (HP:0010780)2.88309324
28Wormian bones (HP:0002645)2.87370863
29Abnormality of dentin (HP:0010299)2.86075843
30Mitral valve prolapse (HP:0001634)2.85330576
31Abnormality of skeletal muscle fiber size (HP:0012084)2.77156524
32Infantile muscular hypotonia (HP:0008947)2.76719723
33Aortic regurgitation (HP:0001659)2.71007557
34J-shaped sella turcica (HP:0002680)2.67241058
35Genu recurvatum (HP:0002816)2.59381768
36Wrist flexion contracture (HP:0001239)2.53747147
37Right ventricular cardiomyopathy (HP:0011663)2.52027189
38Joint stiffness (HP:0001387)2.50580729
39Hyperextensible skin (HP:0000974)2.47500595
40Muscle fiber splitting (HP:0003555)2.43449878
41Aneurysm (HP:0002617)2.37449641
42Slender build (HP:0001533)2.37222960
43Scapular winging (HP:0003691)2.33567234
44Biconcave vertebral bodies (HP:0004586)2.33190397
45Bowel diverticulosis (HP:0005222)2.30431137
46Distal lower limb amyotrophy (HP:0008944)2.28617490
47Short nail (HP:0001799)2.27495789
48Lymphangioma (HP:0100764)2.27283548
49Elbow flexion contracture (HP:0002987)2.25087967
50Deviation of the hallux (HP:0010051)2.25025689
51Premature skin wrinkling (HP:0100678)2.22555488
52Distal lower limb muscle weakness (HP:0009053)2.21377352
53Vascular tortuosity (HP:0004948)2.21000560
54Enlarged penis (HP:0000040)2.20617094
55Difficulty climbing stairs (HP:0003551)2.20175029
56Thin bony cortex (HP:0002753)2.19807019
57Difficulty running (HP:0009046)2.19111653
58Abnormality of the peritoneum (HP:0002585)2.18085889
59Overgrowth (HP:0001548)2.17602517
60Buphthalmos (HP:0000557)2.15375142
61Osteolytic defects of the hand bones (HP:0009699)2.14924480
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.14924480
63Hallux valgus (HP:0001822)2.14084641
64Turricephaly (HP:0000262)2.12962840
65Hypoplasia of the iris (HP:0007676)2.11252612
66Joint laxity (HP:0001388)2.09048639
67Milia (HP:0001056)2.08978327
68Round ear (HP:0100830)2.08512842
69Mitral regurgitation (HP:0001653)2.08267728
70Bronchomalacia (HP:0002780)2.07975218
71Wide anterior fontanel (HP:0000260)2.07274575
72Long toe (HP:0010511)2.05085514
73Hemorrhage of the eye (HP:0011885)2.04751325
74Nuclear cataract (HP:0100018)2.04652111
75Ulnar bowing (HP:0003031)2.04622875
76Breech presentation (HP:0001623)2.03364380
77Bowing of the arm (HP:0006488)2.03281443
78Bowed forearm bones (HP:0003956)2.03281443
79Spondylolisthesis (HP:0003302)2.02740163
80Abnormal delivery (HP:0001787)2.02077630
81Hyporeflexia of lower limbs (HP:0002600)2.00180537
82Abnormality of the acetabulum (HP:0003170)1.99887770
83Congenital glaucoma (HP:0001087)1.99507812
84Arterial tortuosity (HP:0005116)1.98971765
85Disproportionate tall stature (HP:0001519)1.98843556
86Aortic valve stenosis (HP:0001650)1.98690267
87Knee flexion contracture (HP:0006380)1.98041816
88Distal upper limb amyotrophy (HP:0007149)1.97881825
89Upper limb amyotrophy (HP:0009129)1.97881825
90Bell-shaped thorax (HP:0001591)1.97764522
91Radial bowing (HP:0002986)1.97751090
92Mucopolysacchariduria (HP:0008155)1.96123640
93Urinary glycosaminoglycan excretion (HP:0003541)1.96123640
94Ectopia lentis (HP:0001083)1.91612974
95Camptodactyly of toe (HP:0001836)1.90342277
96Flat acetabular roof (HP:0003180)1.89225184
97Striae distensae (HP:0001065)1.87576515
98Coxa vara (HP:0002812)1.85235412
99Venous abnormality (HP:0002624)1.84228034
100Dislocated radial head (HP:0003083)1.83608854
101Dysostosis multiplex (HP:0000943)1.83003423
102Abnormality of polysaccharide metabolism (HP:0011012)1.82712460
103Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82712460
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82712460
105Tibial bowing (HP:0002982)1.81183829
106Abnormality of the radial head (HP:0003995)1.78544055
107Hypercortisolism (HP:0001578)1.77136830
108Deformed sella turcica (HP:0002681)1.76244379
109Coronal craniosynostosis (HP:0004440)1.76054001
110Mesomelia (HP:0003027)1.75869559
111Advanced eruption of teeth (HP:0006288)1.75767251
112Osteoarthritis (HP:0002758)1.74974269
113Spinal cord lesions (HP:0100561)1.74389022
114Syringomyelia (HP:0003396)1.74389022
115Mild short stature (HP:0003502)1.73996352
116Generalized amyotrophy (HP:0003700)1.73992398
117Femoral bowing (HP:0002980)1.73905018
118Emphysema (HP:0002097)1.73780268
119Hypoventilation (HP:0002791)1.73734640
120Hypoplastic ischia (HP:0003175)1.73698889
121Protruding ear (HP:0000411)1.73349217
122Mitral stenosis (HP:0001718)1.73088565
123Tarsal synostosis (HP:0008368)1.71939187
124Asymmetric septal hypertrophy (HP:0001670)1.71866980
125Lumbar hyperlordosis (HP:0002938)1.71581795
126Stridor (HP:0010307)1.71404757
127Aplasia involving bones of the upper limbs (HP:0009823)1.70420139
128Aplasia of the phalanges of the hand (HP:0009802)1.70420139
129Aplasia involving bones of the extremities (HP:0009825)1.70420139
130Osteopenia (HP:0000938)1.69418326
131Acanthosis nigricans (HP:0000956)1.69205533
132Hip contracture (HP:0003273)1.69024148
133Lower limb amyotrophy (HP:0007210)1.66727396
134Neurofibrillary tangles (HP:0002185)1.66193676
135Natal tooth (HP:0000695)1.65835046
136Neoplasm of the heart (HP:0100544)1.65115796
137Venous insufficiency (HP:0005293)1.63569008
138Thin ribs (HP:0000883)1.61683842
139Hand muscle atrophy (HP:0009130)1.61018883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.37308369
2TTN3.80844173
3DDR23.52553939
4SIK13.45096311
5ERN12.95326254
6PDGFRA2.88656030
7PKN22.76527799
8RIPK12.69234359
9LATS12.66045400
10EPHB22.19832301
11FER1.95829643
12EEF2K1.87407421
13LATS21.85105536
14PTK61.81369105
15EPHB11.80239360
16BMX1.76153924
17PTK21.71361766
18SMG11.65784478
19CAMK1D1.65115092
20EPHA21.64027747
21LRRK21.62060949
22PRPF4B1.55085035
23CDK121.51258534
24TNK21.48142739
25CAMK1G1.46395972
26PAK21.42709736
27EPHA31.42329256
28PAK41.40665756
29TGFBR21.32762454
30DMPK1.30804488
31LMTK21.30306250
32TRPM71.28999549
33PRKD31.19847953
34PDGFRB1.17221416
35PAK31.17134666
36NTRK11.08865945
37TESK11.05478592
38MET1.04855982
39ILK1.04837028
40PRKD21.03387999
41MAP3K61.01301223
42MTOR1.00833933
43MAP3K131.00527228
44FGFR10.97269227
45MAPK70.96773883
46CDK60.94417562
47MAP2K10.94101540
48PRKD10.92511549
49ZAP700.91759633
50IRAK30.91664373
51RET0.91540457
52DYRK1B0.91422784
53MST1R0.84709113
54MAP3K30.82447168
55STK380.82393181
56ICK0.82124502
57SIK20.81571401
58PIK3CA0.79571389
59ROCK10.79372076
60STK30.78358403
61HIPK20.76693204
62MOS0.76599357
63FGFR20.75579426
64PRKCH0.75558842
65PTK2B0.75361579
66MAP2K30.74689961
67PDPK10.73344139
68MYLK0.73060070
69MAPK120.73029511
70FGFR40.71653462
71MAP3K70.69113859
72MUSK0.68677535
73NEK90.68563209
74CAMKK20.68505880
75MAPK150.66463693
76ROCK20.64332872
77MAP4K10.63936630
78CAMKK10.62964387
79WNK10.60477027
80PIK3CG0.60137792
81MAP3K20.59570374
82RPS6KA40.58792577
83NTRK30.58581127
84MARK20.56654337
85CDC42BPA0.56484361
86PHKG10.54392842
87PHKG20.54392842
88MAP3K100.54180305
89PAK60.53291046
90MAP2K60.51475079
91PRKG20.50513049
92AKT30.49669570
93SRC0.49446322
94WNK40.47700928
95JAK10.47290161
96BLK0.46918697
97TBK10.45947287
98FGFR30.45099267
99RPS6KA20.44711922
100TYK20.44702434
101CHUK0.44040718
102TAOK10.43413705
103MAP2K20.43316012
104MAPKAPK30.42953770
105ERBB40.42837328
106MAPK110.41013001
107JAK30.40636394
108SGK30.40017673
109GSK3A0.39801786
110INSR0.39579370
111MAP3K110.38596652
112PRKAA20.38169246
113INSRR0.37773773
114SCYL20.37735710
115MAPK80.35704151
116FLT30.34743084
117ERBB20.34725420
118EPHA40.34712220
119RPS6KL10.34518982
120RPS6KC10.34518982
121CDK90.34397191
122TYRO30.34243144
123MAP3K10.33796577
124UHMK10.33428389
125CAMK10.32509611
126ABL10.31929841
127RPS6KA60.31860857
128MAPKAPK50.30959630
129PDK30.30825437
130PDK40.30825437
131DAPK30.29784627
132HCK0.28074103

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.60876039
2Focal adhesion_Homo sapiens_hsa045102.61960810
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.58427181
4Protein digestion and absorption_Homo sapiens_hsa049742.14114725
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.13366931
6Other glycan degradation_Homo sapiens_hsa005112.11540941
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99910129
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.95836518
9Amoebiasis_Homo sapiens_hsa051461.94999357
10Proteoglycans in cancer_Homo sapiens_hsa052051.89405060
11Dilated cardiomyopathy_Homo sapiens_hsa054141.87526980
12Small cell lung cancer_Homo sapiens_hsa052221.76796114
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75709156
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75124490
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72482514
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60568250
17Bladder cancer_Homo sapiens_hsa052191.58294513
18Adherens junction_Homo sapiens_hsa045201.56735737
19Basal cell carcinoma_Homo sapiens_hsa052171.44651729
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42753252
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.38218528
22Hippo signaling pathway_Homo sapiens_hsa043901.33999543
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30986564
24Chronic myeloid leukemia_Homo sapiens_hsa052201.28377255
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28255677
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24483962
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24125347
28Fatty acid biosynthesis_Homo sapiens_hsa000611.19615620
29Notch signaling pathway_Homo sapiens_hsa043301.17139389
30TGF-beta signaling pathway_Homo sapiens_hsa043501.15967060
31Melanoma_Homo sapiens_hsa052181.15087610
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.12958508
33Ovarian steroidogenesis_Homo sapiens_hsa049131.08660794
34Hedgehog signaling pathway_Homo sapiens_hsa043401.08500943
35Tight junction_Homo sapiens_hsa045301.07462338
36Insulin resistance_Homo sapiens_hsa049311.07376620
37MicroRNAs in cancer_Homo sapiens_hsa052061.05654896
38Prostate cancer_Homo sapiens_hsa052151.05048398
39Prion diseases_Homo sapiens_hsa050201.04823561
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.04202604
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04084783
42Choline metabolism in cancer_Homo sapiens_hsa052311.03405624
43Toxoplasmosis_Homo sapiens_hsa051451.02683552
44PPAR signaling pathway_Homo sapiens_hsa033201.00875094
45Malaria_Homo sapiens_hsa051441.00596228
46Platelet activation_Homo sapiens_hsa046110.99198951
47Lysine degradation_Homo sapiens_hsa003100.97641741
48Glioma_Homo sapiens_hsa052140.96011202
49Bile secretion_Homo sapiens_hsa049760.95643737
50Pathways in cancer_Homo sapiens_hsa052000.94244631
51AMPK signaling pathway_Homo sapiens_hsa041520.94227325
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92598010
53Melanogenesis_Homo sapiens_hsa049160.91226660
54ErbB signaling pathway_Homo sapiens_hsa040120.90948301
55Wnt signaling pathway_Homo sapiens_hsa043100.88647694
56Estrogen signaling pathway_Homo sapiens_hsa049150.88142765
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.86351839
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86192179
59Pancreatic cancer_Homo sapiens_hsa052120.85767543
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85496479
61Insulin signaling pathway_Homo sapiens_hsa049100.84370177
62Renal cell carcinoma_Homo sapiens_hsa052110.83556184
63ABC transporters_Homo sapiens_hsa020100.83485475
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82359120
65Rap1 signaling pathway_Homo sapiens_hsa040150.81518170
66Complement and coagulation cascades_Homo sapiens_hsa046100.81238081
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81005674
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79688296
69HIF-1 signaling pathway_Homo sapiens_hsa040660.79198371
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79090085
71Endometrial cancer_Homo sapiens_hsa052130.78950018
72Axon guidance_Homo sapiens_hsa043600.78152410
73Inositol phosphate metabolism_Homo sapiens_hsa005620.77759538
74Long-term potentiation_Homo sapiens_hsa047200.76624475
75Viral myocarditis_Homo sapiens_hsa054160.76595265
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75936160
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75199818
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.74344301
79Colorectal cancer_Homo sapiens_hsa052100.73295927
80Insulin secretion_Homo sapiens_hsa049110.72714784
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71899951
82Gastric acid secretion_Homo sapiens_hsa049710.71159353
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.70298201
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.70260111
85Lysosome_Homo sapiens_hsa041420.69837826
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69647880
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.69129271
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68530052
89Thyroid hormone synthesis_Homo sapiens_hsa049180.68119611
90Fatty acid metabolism_Homo sapiens_hsa012120.67379296
91MAPK signaling pathway_Homo sapiens_hsa040100.66771745
92mTOR signaling pathway_Homo sapiens_hsa041500.66718782
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66226300
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66028904
95Acute myeloid leukemia_Homo sapiens_hsa052210.65715053
96GnRH signaling pathway_Homo sapiens_hsa049120.64428691
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63728017
98Cholinergic synapse_Homo sapiens_hsa047250.63177133
99VEGF signaling pathway_Homo sapiens_hsa043700.62672938
100Circadian entrainment_Homo sapiens_hsa047130.62460202
101Gap junction_Homo sapiens_hsa045400.61790203
102Thyroid cancer_Homo sapiens_hsa052160.61353702
103Prolactin signaling pathway_Homo sapiens_hsa049170.60883997
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59301990
105Cocaine addiction_Homo sapiens_hsa050300.58221827
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57938504
107Endocytosis_Homo sapiens_hsa041440.57473802
108Renin secretion_Homo sapiens_hsa049240.57076623
109Hepatitis C_Homo sapiens_hsa051600.56548305
110Oxytocin signaling pathway_Homo sapiens_hsa049210.56306946
111Calcium signaling pathway_Homo sapiens_hsa040200.56155192
112Glucagon signaling pathway_Homo sapiens_hsa049220.56029069
113Dorso-ventral axis formation_Homo sapiens_hsa043200.55878748
114TNF signaling pathway_Homo sapiens_hsa046680.54229016
115Type II diabetes mellitus_Homo sapiens_hsa049300.53047824
116cAMP signaling pathway_Homo sapiens_hsa040240.50137227
117Salivary secretion_Homo sapiens_hsa049700.49664495
118Glycerolipid metabolism_Homo sapiens_hsa005610.48967771
119Ras signaling pathway_Homo sapiens_hsa040140.47806441
120Non-small cell lung cancer_Homo sapiens_hsa052230.47633997
121FoxO signaling pathway_Homo sapiens_hsa040680.47453432
122Salmonella infection_Homo sapiens_hsa051320.46623627
123Fatty acid degradation_Homo sapiens_hsa000710.45170140

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