LTBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.72362890
2sarcomere organization (GO:0045214)5.10285400
3myofibril assembly (GO:0030239)4.79148540
4plasma membrane repair (GO:0001778)4.78388811
5protein heterotrimerization (GO:0070208)4.61186034
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.58208401
7gonadal mesoderm development (GO:0007506)4.53904908
8negative regulation of potassium ion transmembrane transport (GO:1901380)4.40385026
9peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.39399120
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.25679563
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.19253893
12heart trabecula formation (GO:0060347)4.11455333
13vascular endothelial growth factor signaling pathway (GO:0038084)4.06021647
14cardiac muscle cell development (GO:0055013)3.90004026
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.84589918
16regulation of skeletal muscle contraction (GO:0014819)3.84168855
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.83295476
18basement membrane organization (GO:0071711)3.82968454
19cell migration involved in heart development (GO:0060973)3.79335336
20regulation of cardioblast differentiation (GO:0051890)3.77061249
21actin-myosin filament sliding (GO:0033275)3.76612794
22muscle filament sliding (GO:0030049)3.76612794
23glomerular basement membrane development (GO:0032836)3.75187929
24cardiac cell development (GO:0055006)3.72195449
25ventricular cardiac muscle cell action potential (GO:0086005)3.70557220
26actomyosin structure organization (GO:0031032)3.69115933
27glomerular filtration (GO:0003094)3.66044745
28fibril organization (GO:0097435)3.63313804
29regulation of p38MAPK cascade (GO:1900744)3.62101052
30cardiac muscle contraction (GO:0060048)3.60336930
31renal filtration (GO:0097205)3.55435648
32carnitine shuttle (GO:0006853)3.53700898
33regulation of actin filament-based movement (GO:1903115)3.50383079
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.48801402
35epithelial cell-cell adhesion (GO:0090136)3.47600858
36retina vasculature morphogenesis in camera-type eye (GO:0061299)3.47276241
37endothelial cell chemotaxis (GO:0035767)3.43170696
38striated muscle hypertrophy (GO:0014897)3.42870018
39cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.41386601
40negative regulation of cardiac muscle tissue growth (GO:0055022)3.40488445
41negative regulation of heart growth (GO:0061117)3.40488445
42barbed-end actin filament capping (GO:0051016)3.39739161
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.38994958
44keratan sulfate catabolic process (GO:0042340)3.35977925
45ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.35930490
46blood vessel maturation (GO:0001955)3.34998344
47fatty acid transmembrane transport (GO:1902001)3.30016828
48trabecula formation (GO:0060343)3.29806651
49cardiac muscle tissue morphogenesis (GO:0055008)3.28311490
50atrioventricular valve morphogenesis (GO:0003181)3.25430361
51hemidesmosome assembly (GO:0031581)3.24612428
52venous blood vessel morphogenesis (GO:0048845)3.24603483
53negative regulation of catenin import into nucleus (GO:0035414)3.23463692
54endothelial cell morphogenesis (GO:0001886)3.23462864
55actin-mediated cell contraction (GO:0070252)3.16188373
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.13299265
57cardiac muscle hypertrophy (GO:0003300)3.12832354
58lymphangiogenesis (GO:0001946)3.12767969
59lymph vessel development (GO:0001945)3.11286502
60adult heart development (GO:0007512)3.10805921
61muscle tissue morphogenesis (GO:0060415)3.10647338
62adhesion of symbiont to host cell (GO:0044650)3.09921640
63virion attachment to host cell (GO:0019062)3.09921640
64regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09144699
65endothelial tube morphogenesis (GO:0061154)3.07441136
66morphogenesis of an endothelium (GO:0003159)3.07441136
67muscle hypertrophy (GO:0014896)3.00341792
68cell-substrate junction assembly (GO:0007044)2.98603463
69extracellular fibril organization (GO:0043206)2.98283673
70mannose metabolic process (GO:0006013)2.98076532
71lung vasculature development (GO:0060426)2.97620804
72fibroblast migration (GO:0010761)2.97593752
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.94825162
74regulation of extracellular matrix disassembly (GO:0010715)2.94002012
75cell-substrate adherens junction assembly (GO:0007045)2.93268685
76focal adhesion assembly (GO:0048041)2.93268685
77cell communication involved in cardiac conduction (GO:0086065)2.90655798
78negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.90517672
79surfactant homeostasis (GO:0043129)2.87962390
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87921251
81negative regulation of erythrocyte differentiation (GO:0045647)2.85357484
82apoptotic cell clearance (GO:0043277)2.84498724
83collagen fibril organization (GO:0030199)2.84377669
84adhesion of symbiont to host (GO:0044406)2.84117389
85semaphorin-plexin signaling pathway (GO:0071526)2.83915803
86stress fiber assembly (GO:0043149)2.81322025
87positive regulation of p38MAPK cascade (GO:1900745)2.80737976
88positive regulation of receptor recycling (GO:0001921)2.79767268
89tricarboxylic acid cycle (GO:0006099)2.79187425
90regulation of glucose import in response to insulin stimulus (GO:2001273)2.78777121
91extracellular matrix assembly (GO:0085029)2.77399043
92anatomical structure regression (GO:0060033)2.75926250
93cardiac muscle cell proliferation (GO:0060038)2.75829731
94Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.75696300
95cell migration involved in sprouting angiogenesis (GO:0002042)2.75528451
96oxygen transport (GO:0015671)2.74469554
97regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74309222
98collagen metabolic process (GO:0032963)2.74218736
99positive regulation of pseudopodium assembly (GO:0031274)2.73982135
100adherens junction assembly (GO:0034333)2.73711229
101skeletal muscle adaptation (GO:0043501)2.71834541
102regulation of the force of heart contraction (GO:0002026)2.70407446
103regulation of pseudopodium assembly (GO:0031272)2.68904795
104negative regulation of chondrocyte differentiation (GO:0032331)2.67748610
105multicellular organismal macromolecule metabolic process (GO:0044259)2.67564915
106regulation of striated muscle contraction (GO:0006942)2.67025104
107respiratory tube development (GO:0030323)2.66504242
108regulation of sarcomere organization (GO:0060297)2.66248465
109actin filament-based movement (GO:0030048)2.65322324
110type B pancreatic cell proliferation (GO:0044342)2.65261780
111regulation of endothelial cell differentiation (GO:0045601)2.64852679
112striated muscle contraction (GO:0006941)2.64224706
113regulation of fatty acid oxidation (GO:0046320)2.63934112
114dermatan sulfate metabolic process (GO:0030205)2.63816646
115ovulation from ovarian follicle (GO:0001542)2.63805409
116apoptotic process involved in morphogenesis (GO:0060561)2.63145835
117peripheral nervous system axon ensheathment (GO:0032292)2.62297123
118myelination in peripheral nervous system (GO:0022011)2.62297123
119desmosome organization (GO:0002934)2.60984245
120collagen catabolic process (GO:0030574)2.60971847
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60933068
122regulation of establishment of planar polarity (GO:0090175)2.60838124
123heart morphogenesis (GO:0003007)2.60786500
124cardiac muscle adaptation (GO:0014887)2.60534301
125cardiac muscle hypertrophy in response to stress (GO:0014898)2.60534301
126muscle hypertrophy in response to stress (GO:0003299)2.60534301
127metanephric mesenchyme development (GO:0072075)2.60040641
128UV protection (GO:0009650)2.58560495
129negative regulation of fatty acid transport (GO:2000192)2.58225732
130outflow tract septum morphogenesis (GO:0003148)2.56359369
131regulation of cardiac muscle cell contraction (GO:0086004)2.55857391
132carnitine transmembrane transport (GO:1902603)2.54707539
133blood vessel endothelial cell migration (GO:0043534)2.54694896
134cardiac muscle cell action potential involved in contraction (GO:0086002)2.54046065
135multicellular organismal metabolic process (GO:0044236)2.53930584
136NADH metabolic process (GO:0006734)2.51554594
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.51264305
138convergent extension (GO:0060026)2.49185034
139glial cell migration (GO:0008347)2.48649628
140response to laminar fluid shear stress (GO:0034616)2.48538996
141cell volume homeostasis (GO:0006884)2.47015485
142negative regulation of cartilage development (GO:0061037)2.46100776
143bone trabecula formation (GO:0060346)2.45808967
144multicellular organismal catabolic process (GO:0044243)2.44700054
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44638764
146cell-cell junction maintenance (GO:0045217)2.43580415
147kidney mesenchyme development (GO:0072074)2.41933165
148mesenchymal cell differentiation involved in renal system development (GO:2001012)2.40339402
149mesenchymal cell differentiation involved in kidney development (GO:0072161)2.40339402
150insulin-like growth factor receptor signaling pathway (GO:0048009)2.39905682
151cell differentiation involved in metanephros development (GO:0072202)2.39126211
152extracellular matrix disassembly (GO:0022617)2.38606611
153regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.38537774
154regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.38361147
155sequestering of extracellular ligand from receptor (GO:0035581)2.37519647
156negative regulation of myotube differentiation (GO:0010832)2.37510510
157cGMP-mediated signaling (GO:0019934)2.34597217
158response to fluid shear stress (GO:0034405)2.34586927
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34551384
160non-canonical Wnt signaling pathway (GO:0035567)2.34105509
161protein retention in ER lumen (GO:0006621)2.33137112
162cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.33079902
163negative regulation of cell size (GO:0045792)2.32505380
164cell proliferation involved in metanephros development (GO:0072203)2.30476987
165cochlea morphogenesis (GO:0090103)2.26469895
166skeletal muscle organ development (GO:0060538)2.24019258
167negative regulation of smooth muscle cell migration (GO:0014912)2.24016361
168diaphragm development (GO:0060539)2.23539761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33660623
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.51965621
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.23691147
4CLOCK_20551151_ChIP-Seq_293T_Human3.12160448
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.10762720
6ZNF263_19887448_ChIP-Seq_K562_Human2.82849007
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.56067927
8* TBX20_22328084_ChIP-Seq_HEART_Mouse2.34822173
9* TBX20_22080862_ChIP-Seq_HEART_Mouse2.34822173
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34437995
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.30351592
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28105148
13* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.24268092
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14107604
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.10488484
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.08790081
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.08767619
18* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01132289
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00098520
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.97599359
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92794873
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90514588
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88247361
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87163122
25VDR_21846776_ChIP-Seq_THP-1_Human1.83666810
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77598676
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76350643
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73407087
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.73262753
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72445068
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.71779869
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70206060
33LXR_22292898_ChIP-Seq_THP-1_Human1.66846853
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66827053
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66783082
36SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63234440
37RACK7_27058665_Chip-Seq_MCF-7_Human1.63189111
38* KDM2B_26808549_Chip-Seq_K562_Human1.62794410
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61782174
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61782174
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61782174
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60536304
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57334960
44* KDM2B_26808549_Chip-Seq_DND41_Human1.54844907
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.54604054
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.49712049
47P68_20966046_ChIP-Seq_HELA_Human1.48574454
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47862067
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.45242784
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45017225
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44569425
52* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40787408
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40216384
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38352721
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36194003
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35847501
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34659156
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33494642
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32795311
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.32697386
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.32296662
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32202406
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28644460
64SMC3_22415368_ChIP-Seq_MEFs_Mouse1.27968484
65CJUN_26792858_Chip-Seq_BT549_Human1.27574639
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27546133
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27432235
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27312182
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27167804
70* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25831567
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25176227
72TP53_22127205_ChIP-Seq_IMR90_Human1.24923705
73DROSHA_22980978_ChIP-Seq_HELA_Human1.24257431
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.23393897
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23089029
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22034124
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21926744
78* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21521663
79* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20615066
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20236403
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.19061956
82MYC_22102868_ChIP-Seq_BL_Human1.18302188
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18201595
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15693517
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15101502
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13742165
87CREB1_26743006_Chip-Seq_LNCaP_Human1.13697272
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12475628
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12380624
90* ATF3_27146783_Chip-Seq_COLON_Human1.12347476
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11784490
92* KDM2B_26808549_Chip-Seq_JURKAT_Human1.11274207
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10687060
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10629790
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10221241
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.08738016
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08003439
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.07447199
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07269879
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.06879458
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06420233
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06203434
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06051986
104CTCF_27219007_Chip-Seq_Bcells_Human1.06005866
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05345514
106TCF7_22412390_ChIP-Seq_EML_Mouse1.04814613
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04341214
108EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04341214
109TP63_22573176_ChIP-Seq_HFKS_Human1.03651850
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03630410
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03440276
112MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02069538
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02009586
114GATA1_19941826_ChIP-Seq_K562_Human1.01215851
115* NCOR1_26117541_ChIP-Seq_K562_Human1.00102142
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98871907
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98746527
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98268635
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97031332
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96684003
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.95895864
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.95667397
123VDR_24763502_ChIP-Seq_THP-1_Human0.94680032
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.94177172
125RNF2_27304074_Chip-Seq_ESCs_Mouse0.94151974
126SA1_27219007_Chip-Seq_Bcells_Human0.94126120
127EGR1_19374776_ChIP-ChIP_THP-1_Human0.93730697
128* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93535007
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92511293
130SMC4_20622854_ChIP-Seq_HELA_Human0.92424481
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91025537
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90704758
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90228182
134GATA1_22025678_ChIP-Seq_K562_Human0.89119249
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88208015
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86794969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.74435741
2MP0000751_myopathy4.54009478
3MP0002837_dystrophic_cardiac_calcinosis4.28160134
4MP0004084_abnormal_cardiac_muscle4.24578516
5MP0005275_abnormal_skin_tensile3.94236586
6MP0004272_abnormal_basement_membrane3.09242198
7MP0005503_abnormal_tendon_morphology3.03809516
8MP0003705_abnormal_hypodermis_morpholog2.98211125
9MP0004036_abnormal_muscle_relaxation2.97959023
10MP0010368_abnormal_lymphatic_system2.92907374
11MP0004215_abnormal_myocardial_fiber2.77984568
12MP0003646_muscle_fatigue2.60729069
13* MP0005330_cardiomyopathy2.43958612
14MP0000750_abnormal_muscle_regeneration2.42994488
15MP0006138_congestive_heart_failure2.32978224
16MP0004087_abnormal_muscle_fiber2.23297993
17MP0000749_muscle_degeneration2.16930449
18MP0004858_abnormal_nervous_system2.12113816
19MP0003279_aneurysm2.11228896
20MP0003828_pulmonary_edema2.04861327
21MP0005385_cardiovascular_system_phenoty2.02633496
22MP0001544_abnormal_cardiovascular_syste2.02633496
23MP0005409_darkened_coat_color1.99710755
24MP0010630_abnormal_cardiac_muscle1.98042350
25MP0008775_abnormal_heart_ventricle1.96815648
26MP0002972_abnormal_cardiac_muscle1.92074885
27MP0003566_abnormal_cell_adhesion1.89600904
28MP0005623_abnormal_meninges_morphology1.88091595
29MP0001849_ear_inflammation1.84880593
30* MP0001958_emphysema1.84551626
31MP0001879_abnormal_lymphatic_vessel1.81583590
32MP0002108_abnormal_muscle_morphology1.78872521
33MP0005620_abnormal_muscle_contractility1.78657232
34MP0004130_abnormal_muscle_cell1.75939735
35MP0002933_joint_inflammation1.65689641
36* MP0002106_abnormal_muscle_physiology1.59336653
37MP0005167_abnormal_blood-brain_barrier1.58510798
38MP0005670_abnormal_white_adipose1.57631455
39* MP0005369_muscle_phenotype1.48286237
40MP0003137_abnormal_impulse_conducting1.47798182
41MP0004484_altered_response_of1.46831788
42MP0004145_abnormal_muscle_electrophysio1.43685205
43MP0000566_synostosis1.43364303
44MP0006054_spinal_hemorrhage1.42726938
45MP0002269_muscular_atrophy1.42624007
46MP0004085_abnormal_heartbeat1.39397542
47MP0000767_abnormal_smooth_muscle1.38905528
48MP0002127_abnormal_cardiovascular_syste1.38631160
49MP0005666_abnormal_adipose_tissue1.37367115
50* MP0000759_abnormal_skeletal_muscle1.35768961
51MP0000678_abnormal_parathyroid_gland1.35515616
52MP0004185_abnormal_adipocyte_glucose1.26011405
53MP0002060_abnormal_skin_morphology1.24681052
54MP0000747_muscle_weakness1.24589547
55MP0000343_altered_response_to1.21743837
56MP0005375_adipose_tissue_phenotype1.18829881
57MP0003567_abnormal_fetal_cardiomyocyte1.15008400
58MP0005058_abnormal_lysosome_morphology1.14520257
59MP0002128_abnormal_blood_circulation1.13960404
60MP0000266_abnormal_heart_morphology1.12879779
61MP0000733_abnormal_muscle_development1.09446795
62MP0005390_skeleton_phenotype1.09106507
63MP0003045_fibrosis1.08976467
64MP0004233_abnormal_muscle_weight1.08341950
65MP0002932_abnormal_joint_morphology1.05816505
66MP0005508_abnormal_skeleton_morphology1.05138891
67MP0002295_abnormal_pulmonary_circulatio1.05047065
68MP0000013_abnormal_adipose_tissue1.04985859
69MP0009379_abnormal_foot_pigmentation1.03151196
70MP0001348_abnormal_lacrimal_gland1.02618481
71MP0003453_abnormal_keratinocyte_physiol1.02411494
72MP0000462_abnormal_digestive_system1.02150991
73MP0000003_abnormal_adipose_tissue1.01185772
74MP0001542_abnormal_bone_strength0.99296701
75MP0003941_abnormal_skin_development0.98356203
76MP0003283_abnormal_digestive_organ0.98242155
77MP0000049_abnormal_middle_ear0.97903923
78MP0002925_abnormal_cardiovascular_devel0.97423656
79MP0002234_abnormal_pharynx_morphology0.96020928
80MP0000762_abnormal_tongue_morphology0.95742095
81MP0004782_abnormal_surfactant_physiolog0.94723589
82MP0003115_abnormal_respiratory_system0.94710406
83MP0000681_abnormal_thyroid_gland0.93311616
84MP0005165_increased_susceptibility_to0.91747782
85MP0001243_abnormal_dermal_layer0.90765185
86MP0009840_abnormal_foam_cell0.90716054
87MP0003950_abnormal_plasma_membrane0.90180052
88MP0005360_urolithiasis0.90102932
89MP0003942_abnormal_urinary_system0.89621946
90MP0000163_abnormal_cartilage_morphology0.87285000
91MP0008995_early_reproductive_senescence0.85383544
92MP0001664_abnormal_digestion0.85238665
93MP0001614_abnormal_blood_vessel0.84985865
94MP0003221_abnormal_cardiomyocyte_apopto0.84913751
95MP0009278_abnormal_bone_marrow0.83659357
96MP0001299_abnormal_eye_distance/0.82491361
97MP0002998_abnormal_bone_remodeling0.82290172
98MP0000534_abnormal_ureter_morphology0.81227856
99MP0002971_abnormal_brown_adipose0.80630422
100MP0009384_cardiac_valve_regurgitation0.80535037
101MP0000428_abnormal_craniofacial_morphol0.79214274
102MP0004510_myositis0.78674967
103MP0005076_abnormal_cell_differentiation0.78644070
104MP0005023_abnormal_wound_healing0.78622542
105MP0005257_abnormal_intraocular_pressure0.77347253
106MP0005595_abnormal_vascular_smooth0.77210134
107MP0008961_abnormal_basal_metabolism0.77061199
108MP0002116_abnormal_craniofacial_bone0.75109377
109MP0003385_abnormal_body_wall0.74543211
110MP0010234_abnormal_vibrissa_follicle0.74430426
111MP0002332_abnormal_exercise_endurance0.74226774
112MP0003329_amyloid_beta_deposits0.74157588
113MP0009780_abnormal_chondrocyte_physiolo0.72995957
114MP0001661_extended_life_span0.72783274
115MP0000579_abnormal_nail_morphology0.72003008
116MP0003091_abnormal_cell_migration0.70620337
117MP0002877_abnormal_melanocyte_morpholog0.69937698
118MP0002115_abnormal_skeleton_extremities0.69630901
119MP0002896_abnormal_bone_mineralization0.66923844
120MP0000230_abnormal_systemic_arterial0.65378005
121MP0002168_other_aberrant_phenotype0.63927595
122MP0000249_abnormal_blood_vessel0.63885725
123MP0000537_abnormal_urethra_morphology0.62288245
124MP0002249_abnormal_larynx_morphology0.62052201
125MP0003935_abnormal_craniofacial_develop0.61615581
126MP0001784_abnormal_fluid_regulation0.61362705
127MP0002796_impaired_skin_barrier0.61212887
128MP0005377_hearing/vestibular/ear_phenot0.59601539
129MP0003878_abnormal_ear_physiology0.59601539
130MP0003119_abnormal_digestive_system0.56569019
131MP0010030_abnormal_orbit_morphology0.56437831
132* MP0002133_abnormal_respiratory_system0.54374957
133* MP0005388_respiratory_system_phenotype0.54374957
134MP0000467_abnormal_esophagus_morphology0.54193316
135MP0003252_abnormal_bile_duct0.52736905

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)5.76460912
2Muscle fiber splitting (HP:0003555)5.36039774
3Sudden death (HP:0001699)5.18531917
4Ankle contracture (HP:0006466)4.74950343
5Ventricular tachycardia (HP:0004756)4.63461686
6Protrusio acetabuli (HP:0003179)4.58517684
7Broad metatarsal (HP:0001783)4.55625478
8Type 1 muscle fiber predominance (HP:0003803)4.38474268
9Right ventricular cardiomyopathy (HP:0011663)4.32669205
10Hyporeflexia of lower limbs (HP:0002600)4.13212744
11Cerebral aneurysm (HP:0004944)3.94546702
12Atrial fibrillation (HP:0005110)3.81767764
13Increased variability in muscle fiber diameter (HP:0003557)3.75360400
14Lipoatrophy (HP:0100578)3.69647210
15Premature rupture of membranes (HP:0001788)3.64306059
16Primary atrial arrhythmia (HP:0001692)3.56180762
17Calf muscle hypertrophy (HP:0008981)3.55142341
18Mildly elevated creatine phosphokinase (HP:0008180)3.51985482
19Supraventricular arrhythmia (HP:0005115)3.50104961
20Abnormality of the calf musculature (HP:0001430)3.48200471
21Cervical subluxation (HP:0003308)3.46102382
22Obstructive sleep apnea (HP:0002870)3.43981216
23Exercise-induced myalgia (HP:0003738)3.42624823
24Supraventricular tachycardia (HP:0004755)3.39027176
25Spinal rigidity (HP:0003306)3.35186016
26Abnormality of skeletal muscle fiber size (HP:0012084)3.32308672
27Vascular tortuosity (HP:0004948)3.28454367
28Aortic dissection (HP:0002647)3.22908625
29Exercise-induced muscle cramps (HP:0003710)3.20316143
30Muscle hypertrophy of the lower extremities (HP:0008968)3.12046750
31Difficulty running (HP:0009046)3.11810368
32Aortic aneurysm (HP:0004942)3.09365475
33Abnormality of the left ventricular outflow tract (HP:0011103)2.99938328
34Subaortic stenosis (HP:0001682)2.99938328
35Shallow orbits (HP:0000586)2.96609518
36Difficulty climbing stairs (HP:0003551)2.93561752
37Follicular hyperkeratosis (HP:0007502)2.93181353
38Aneurysm (HP:0002617)2.84651787
39Thin bony cortex (HP:0002753)2.83774515
40Syncope (HP:0001279)2.80666163
41Arterial tortuosity (HP:0005116)2.79500020
42Lymphangioma (HP:0100764)2.79018119
43Prolonged QT interval (HP:0001657)2.70800464
44Wormian bones (HP:0002645)2.70347359
45Bundle branch block (HP:0011710)2.69924455
46EMG: myopathic abnormalities (HP:0003458)2.67670569
47Dilated cardiomyopathy (HP:0001644)2.67587498
48Vertebral compression fractures (HP:0002953)2.67532870
49Broad face (HP:0000283)2.66859508
50Mitral valve prolapse (HP:0001634)2.63734308
51Atrophic scars (HP:0001075)2.63056159
52Myotonia (HP:0002486)2.62289980
53Asymmetric septal hypertrophy (HP:0001670)2.62138917
54Myoglobinuria (HP:0002913)2.60152868
55Aortic regurgitation (HP:0001659)2.60119607
56Atrioventricular block (HP:0001678)2.57808797
57Ventricular arrhythmia (HP:0004308)2.57490629
58Polycythemia (HP:0001901)2.52143257
59Joint stiffness (HP:0001387)2.49892163
60Ventricular fibrillation (HP:0001663)2.49399624
61Mesangial abnormality (HP:0001966)2.46814181
62Neonatal short-limb short stature (HP:0008921)2.46346237
63Wrist flexion contracture (HP:0001239)2.44103056
64Abnormal atrioventricular conduction (HP:0005150)2.42957419
65Flat cornea (HP:0007720)2.41978578
66Turricephaly (HP:0000262)2.40913196
67Fragile skin (HP:0001030)2.40032894
68Mitral regurgitation (HP:0001653)2.39214726
69Heart block (HP:0012722)2.38662459
70Round ear (HP:0100830)2.38018440
71Slender build (HP:0001533)2.36896583
72Biconcave vertebral bodies (HP:0004586)2.34415035
73Palpitations (HP:0001962)2.34356995
74Testicular atrophy (HP:0000029)2.33137066
75Abnormality of complement system (HP:0005339)2.33013912
76Systemic lupus erythematosus (HP:0002725)2.25081840
77Soft skin (HP:0000977)2.24956680
78Distal lower limb muscle weakness (HP:0009053)2.23830782
79Striae distensae (HP:0001065)2.22705872
80* Bladder diverticulum (HP:0000015)2.21191000
81Disproportionate tall stature (HP:0001519)2.20345373
82Ulnar bowing (HP:0003031)2.18998704
83Genu recurvatum (HP:0002816)2.15071176
84Facial diplegia (HP:0001349)2.14616409
85Dilatation of the ascending aorta (HP:0005111)2.12538070
86Ulnar deviation of the wrist (HP:0003049)2.09857716
87Stridor (HP:0010307)2.09441109
88Generalized amyotrophy (HP:0003700)2.07439074
89Limb-girdle muscle weakness (HP:0003325)2.06905375
90* Joint laxity (HP:0001388)2.06442179
91Hematochezia (HP:0002573)2.05466235
92Abnormality of the 4th metacarpal (HP:0010012)2.03740161
93Hemorrhage of the eye (HP:0011885)2.03722444
94Hypoplastic ischia (HP:0003175)2.03042235
95Centrally nucleated skeletal muscle fibers (HP:0003687)2.01198124
96Aortic valve stenosis (HP:0001650)1.99912398
97Neoplasm of the heart (HP:0100544)1.98104535
98Complement deficiency (HP:0004431)1.96227924
99Coronal craniosynostosis (HP:0004440)1.95785658
100Ectopia lentis (HP:0001083)1.94514252
101Wide anterior fontanel (HP:0000260)1.93536453
102* Pulmonary artery stenosis (HP:0004415)1.93228512
103Hyperacusis (HP:0010780)1.92713714
104Myopathic facies (HP:0002058)1.92137091
105Persistence of primary teeth (HP:0006335)1.91942323
106Limb-girdle muscle atrophy (HP:0003797)1.91055513
107Thin ribs (HP:0000883)1.90624588
108Interstitial pulmonary disease (HP:0006530)1.89998762
109Scapular winging (HP:0003691)1.88774504
110Venous insufficiency (HP:0005293)1.86662643
111Hip contracture (HP:0003273)1.86015942
112Hypoventilation (HP:0002791)1.84830025
113Abnormality of the calcaneus (HP:0008364)1.84821192
114Venous abnormality (HP:0002624)1.83646258
115Natal tooth (HP:0000695)1.83097514
116Abnormality of the ischium (HP:0003174)1.82232102
117Overgrowth (HP:0001548)1.81912848
118Advanced eruption of teeth (HP:0006288)1.81824809
119Calcaneovalgus deformity (HP:0001848)1.81524047
120Renovascular hypertension (HP:0100817)1.81042443
121Osteolytic defects of the phalanges of the hand (HP:0009771)1.80797255
122Osteolytic defects of the hand bones (HP:0009699)1.80797255
123Distal lower limb amyotrophy (HP:0008944)1.80471945
124Atelectasis (HP:0100750)1.80252697
125Proximal amyotrophy (HP:0007126)1.79666773
126Malnutrition (HP:0004395)1.79337393
127Bowel diverticulosis (HP:0005222)1.76827174
128Hyperextensible skin (HP:0000974)1.76597874
129Distal upper limb amyotrophy (HP:0007149)1.76092180
130Upper limb amyotrophy (HP:0009129)1.76092180
131Gastrointestinal dysmotility (HP:0002579)1.73645936
132Areflexia of lower limbs (HP:0002522)1.72638293
133Spondylolisthesis (HP:0003302)1.72575256
134Abnormal EKG (HP:0003115)1.72078475
135Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71831479
136Rhabdomyolysis (HP:0003201)1.71751026
137Muscular dystrophy (HP:0003560)1.71553871
138Short 4th metacarpal (HP:0010044)1.70830649
139Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70830649
140Camptodactyly of toe (HP:0001836)1.70385237
141Long toe (HP:0010511)1.69963811
142Hypercortisolism (HP:0001578)1.68399370
143Deformed tarsal bones (HP:0008119)1.68394007
144Joint contractures involving the joints of the feet (HP:0100492)1.68382719
145Flexion contracture of toe (HP:0005830)1.68382719
146* Emphysema (HP:0002097)1.68120047
147Palmoplantar keratoderma (HP:0000982)1.66896303
148Neck muscle weakness (HP:0000467)1.66619719
149Visceral angiomatosis (HP:0100761)1.66475172
150Achilles tendon contracture (HP:0001771)1.66412465
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.65950423
152Short hallux (HP:0010109)1.65328688
153Hypoplasia of the iris (HP:0007676)1.63523394
154Acanthosis nigricans (HP:0000956)1.61778218
155Premature skin wrinkling (HP:0100678)1.61286668
156EMG: neuropathic changes (HP:0003445)1.60805681
157Elfin facies (HP:0004428)1.60494632
158Blue sclerae (HP:0000592)1.60419672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.87955126
2TIE14.38744059
3TRIB33.64933632
4MYLK3.38348928
5RIPK12.98343520
6DMPK2.69910476
7PKN22.62613740
8LMTK22.58296167
9TGFBR22.41226590
10PDGFRA2.34917642
11PHKG12.01915766
12PHKG22.01915766
13LATS11.92901365
14SMG11.79502850
15MAP3K61.76510720
16ERN11.74715640
17EPHB21.71604884
18PRKD31.69394249
19PRPF4B1.63361654
20PDK41.60434560
21PDK31.60434560
22OBSCN1.54347293
23SIK11.48829703
24NTRK11.46807506
25DDR21.46785340
26ICK1.36957801
27FER1.36890108
28LATS21.36739805
29MARK21.35363377
30TESK11.34498068
31BCKDK1.33639435
32PTK61.33372094
33EPHB11.31609011
34RPS6KA21.28607892
35KDR1.25983963
36PTK2B1.22283503
37PRKD11.20832784
38TGFBR11.20416011
39PDK21.19598734
40CDK121.19391632
41MAPKAPK31.18115977
42PRKD21.08106931
43STK38L1.06302479
44CAMK1D1.06290303
45MET1.06072586
46MAPK71.04896803
47FGFR41.04608471
48MAP3K70.98251310
49MAP3K30.95664696
50PAK40.94413848
51CDC42BPA0.94211274
52NEK10.94166374
53STK240.93981023
54PRKCH0.93527454
55PAK20.93267200
56TYRO30.92822681
57MTOR0.90964972
58HIPK20.89698106
59PIK3CA0.87857654
60BMX0.84695063
61ILK0.84116620
62EEF2K0.83583519
63ROCK10.82848861
64CAMK1G0.81554352
65PAK30.79438552
66STK380.77111235
67PDGFRB0.76734286
68PTK20.73985904
69PINK10.71670178
70DYRK1B0.71357255
71MAP3K100.71062447
72MAP2K30.67729602
73PDPK10.66191617
74CAMK40.63447352
75LRRK20.63384079
76EPHA20.63117043
77PRKAA20.60401785
78DAPK30.59778471
79FGFR20.58726501
80MAPK120.58541522
81MAPK40.58037384
82ZAP700.56958413
83EPHA30.56611106
84RPS6KA40.54884009
85MAP3K130.53940113
86MAP3K10.53261928
87WNK40.53010668
88GRK50.52724147
89MAPK150.52539575
90RET0.51377164
91MST1R0.51256461
92GSK3A0.50544890
93TBK10.50472501
94FGFR10.50005266
95FGFR30.49746436
96PRKAA10.49031635
97KIT0.48708265
98WNK10.48696831
99MAPK110.47506562
100GRK60.46999919
101TRPM70.45786932
102FLT30.45686422
103PRKG20.45151133
104CSK0.44700714
105STK30.43612539
106RPS6KL10.42753851
107RPS6KC10.42753851
108INSRR0.41811208
109ROCK20.41069272
110KSR20.40723617
111ERBB20.40507286
112MAPKAPK20.39728882
113TYK20.38782387
114MAP3K110.37596242
115DAPK20.36372704
116RPS6KA60.35740408
117MUSK0.35552426
118MAPK30.35466839
119MAPK10.35178777
120TAOK10.34601643
121STK40.33665771
122JAK30.33023650
123PRKACB0.32857636
124CDK90.32750013
125PIK3CG0.32602725
126MAP2K20.32471896
127MAPK80.31814553
128SRC0.31297662
129CDK60.31130479
130RPS6KA10.31017737
131JAK20.29923234
132JAK10.29763100
133CAMK2G0.29459740
134CLK10.29248503
135CDK40.28748466
136MAP2K60.28577150

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.34279900
2ECM-receptor interaction_Homo sapiens_hsa045123.28374926
3Dilated cardiomyopathy_Homo sapiens_hsa054143.25743730
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.06848811
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.01951481
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.82892865
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.52713725
8Focal adhesion_Homo sapiens_hsa045102.30829028
9Fatty acid degradation_Homo sapiens_hsa000712.27097329
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14987333
11Protein digestion and absorption_Homo sapiens_hsa049742.00078776
12Propanoate metabolism_Homo sapiens_hsa006401.99220157
13Cardiac muscle contraction_Homo sapiens_hsa042601.88332697
14Other glycan degradation_Homo sapiens_hsa005111.88008800
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.86678229
16Fatty acid metabolism_Homo sapiens_hsa012121.84157246
17Amoebiasis_Homo sapiens_hsa051461.67736918
18PPAR signaling pathway_Homo sapiens_hsa033201.66709694
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60358857
20Viral myocarditis_Homo sapiens_hsa054161.59417322
21Adherens junction_Homo sapiens_hsa045201.51971473
22Insulin resistance_Homo sapiens_hsa049311.44658384
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44521115
24Fructose and mannose metabolism_Homo sapiens_hsa000511.43898068
25Notch signaling pathway_Homo sapiens_hsa043301.38953096
26Lysine degradation_Homo sapiens_hsa003101.37551539
27Carbon metabolism_Homo sapiens_hsa012001.34423337
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34147498
29Small cell lung cancer_Homo sapiens_hsa052221.29264786
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28449719
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.25933582
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21337572
33Proteoglycans in cancer_Homo sapiens_hsa052051.20885131
34Renin-angiotensin system_Homo sapiens_hsa046141.18805115
35Dorso-ventral axis formation_Homo sapiens_hsa043201.18705305
36Basal cell carcinoma_Homo sapiens_hsa052171.18624090
37Fatty acid biosynthesis_Homo sapiens_hsa000611.14892523
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14446135
39Arginine biosynthesis_Homo sapiens_hsa002201.13386408
40Acute myeloid leukemia_Homo sapiens_hsa052211.12418837
41Tight junction_Homo sapiens_hsa045301.10269844
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09748213
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.08715799
44Pyruvate metabolism_Homo sapiens_hsa006201.05631419
45Renin secretion_Homo sapiens_hsa049241.05598099
46Nitrogen metabolism_Homo sapiens_hsa009101.04208096
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00849326
48TGF-beta signaling pathway_Homo sapiens_hsa043500.95888901
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95086410
50Hippo signaling pathway_Homo sapiens_hsa043900.93462700
51Hedgehog signaling pathway_Homo sapiens_hsa043400.93420105
52Insulin signaling pathway_Homo sapiens_hsa049100.92638777
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91934260
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91669317
55PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90294916
56Tryptophan metabolism_Homo sapiens_hsa003800.90090090
57AMPK signaling pathway_Homo sapiens_hsa041520.89544002
58Glucagon signaling pathway_Homo sapiens_hsa049220.88006174
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87123431
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84615418
61Bile secretion_Homo sapiens_hsa049760.84082008
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81201205
63Complement and coagulation cascades_Homo sapiens_hsa046100.80464001
64Sulfur relay system_Homo sapiens_hsa041220.80319252
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.80229042
66Ovarian steroidogenesis_Homo sapiens_hsa049130.78901723
67Starch and sucrose metabolism_Homo sapiens_hsa005000.76859656
68Choline metabolism in cancer_Homo sapiens_hsa052310.76785437
69Histidine metabolism_Homo sapiens_hsa003400.76268602
70Pancreatic cancer_Homo sapiens_hsa052120.75901317
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74734031
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.72327700
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71700067
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71593170
75Vitamin digestion and absorption_Homo sapiens_hsa049770.70810141
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.70418880
77Estrogen signaling pathway_Homo sapiens_hsa049150.70287068
78Pathways in cancer_Homo sapiens_hsa052000.70246611
79Pertussis_Homo sapiens_hsa051330.69448761
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69320005
81Type II diabetes mellitus_Homo sapiens_hsa049300.68948786
82cAMP signaling pathway_Homo sapiens_hsa040240.68867588
83HIF-1 signaling pathway_Homo sapiens_hsa040660.68445753
84Toxoplasmosis_Homo sapiens_hsa051450.68148876
85Platelet activation_Homo sapiens_hsa046110.67979779
86Fat digestion and absorption_Homo sapiens_hsa049750.66004993
87Glioma_Homo sapiens_hsa052140.65726331
88Gastric acid secretion_Homo sapiens_hsa049710.65457058
89Pentose phosphate pathway_Homo sapiens_hsa000300.65037365
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.64423282
91Thyroid cancer_Homo sapiens_hsa052160.63175600
92Endometrial cancer_Homo sapiens_hsa052130.61650430
93Biosynthesis of amino acids_Homo sapiens_hsa012300.61579779
94Rap1 signaling pathway_Homo sapiens_hsa040150.61201084
95Prion diseases_Homo sapiens_hsa050200.60609291
96Oxytocin signaling pathway_Homo sapiens_hsa049210.60529169
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60058540
98Prostate cancer_Homo sapiens_hsa052150.59862712
99MicroRNAs in cancer_Homo sapiens_hsa052060.59314590
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58798955
101Butanoate metabolism_Homo sapiens_hsa006500.57923545
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57685133
103beta-Alanine metabolism_Homo sapiens_hsa004100.56913934
104Renal cell carcinoma_Homo sapiens_hsa052110.54245938
105Melanogenesis_Homo sapiens_hsa049160.53678971
106Mineral absorption_Homo sapiens_hsa049780.53655824
107Non-small cell lung cancer_Homo sapiens_hsa052230.53344372
108ErbB signaling pathway_Homo sapiens_hsa040120.52687417
109Thyroid hormone synthesis_Homo sapiens_hsa049180.52677567
110Gap junction_Homo sapiens_hsa045400.52517892
111Axon guidance_Homo sapiens_hsa043600.52478104
112HTLV-I infection_Homo sapiens_hsa051660.51942773
113Endocytosis_Homo sapiens_hsa041440.51363616
114VEGF signaling pathway_Homo sapiens_hsa043700.50110755
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50047528
116Bladder cancer_Homo sapiens_hsa052190.49395124
117Arachidonic acid metabolism_Homo sapiens_hsa005900.49136369
118GnRH signaling pathway_Homo sapiens_hsa049120.49136343
119Calcium signaling pathway_Homo sapiens_hsa040200.47847793
120mTOR signaling pathway_Homo sapiens_hsa041500.46527716
121Malaria_Homo sapiens_hsa051440.43358305
122Chronic myeloid leukemia_Homo sapiens_hsa052200.42967893
123Phenylalanine metabolism_Homo sapiens_hsa003600.42616579
124Glycerolipid metabolism_Homo sapiens_hsa005610.38798260
125Wnt signaling pathway_Homo sapiens_hsa043100.38447273
126Arginine and proline metabolism_Homo sapiens_hsa003300.37456860
127Galactose metabolism_Homo sapiens_hsa000520.34939651
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34880687
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.34337514
130Caffeine metabolism_Homo sapiens_hsa002320.33585862
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33123363

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