LTBR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.54631448
2sulfur amino acid catabolic process (GO:0000098)5.22614584
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.15590586
4L-phenylalanine metabolic process (GO:0006558)5.15590586
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.13676069
6L-phenylalanine catabolic process (GO:0006559)5.13676069
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.87476881
8negative regulation of fibrinolysis (GO:0051918)4.60505207
9aromatic amino acid family catabolic process (GO:0009074)4.58677366
10desmosome organization (GO:0002934)4.54808532
11alpha-linolenic acid metabolic process (GO:0036109)4.48112689
12glyoxylate metabolic process (GO:0046487)4.47724686
13peptidyl-glutamic acid carboxylation (GO:0017187)4.44985039
14protein carboxylation (GO:0018214)4.44985039
15kynurenine metabolic process (GO:0070189)4.22671542
16cysteine metabolic process (GO:0006534)4.21914245
17indole-containing compound catabolic process (GO:0042436)4.13761860
18indolalkylamine catabolic process (GO:0046218)4.13761860
19tryptophan catabolic process (GO:0006569)4.13761860
20complement activation, alternative pathway (GO:0006957)4.13472099
21regulation of fibrinolysis (GO:0051917)4.13388273
22high-density lipoprotein particle remodeling (GO:0034375)4.13006063
23urea cycle (GO:0000050)4.10606847
24urea metabolic process (GO:0019627)4.10606847
25bile acid biosynthetic process (GO:0006699)4.09912297
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09331136
27regulation of protein activation cascade (GO:2000257)4.03318906
28homocysteine metabolic process (GO:0050667)3.97880835
29cellular modified amino acid catabolic process (GO:0042219)3.97668287
30tryptophan metabolic process (GO:0006568)3.91210148
31amino-acid betaine metabolic process (GO:0006577)3.90213852
32lysine metabolic process (GO:0006553)3.87361970
33lysine catabolic process (GO:0006554)3.87361970
34regulation of triglyceride catabolic process (GO:0010896)3.86363299
35plasma lipoprotein particle clearance (GO:0034381)3.84202712
36regulation of complement activation (GO:0030449)3.83206569
37epoxygenase P450 pathway (GO:0019373)3.82671211
38cellular glucuronidation (GO:0052695)3.77719724
39reverse cholesterol transport (GO:0043691)3.76519048
40nitrogen cycle metabolic process (GO:0071941)3.75107929
41coenzyme catabolic process (GO:0009109)3.74219024
42protein-lipid complex remodeling (GO:0034368)3.65654083
43macromolecular complex remodeling (GO:0034367)3.65654083
44plasma lipoprotein particle remodeling (GO:0034369)3.65654083
45regulation of cholesterol esterification (GO:0010872)3.65557358
46negative regulation of cholesterol transport (GO:0032375)3.63519197
47negative regulation of sterol transport (GO:0032372)3.63519197
48serine family amino acid catabolic process (GO:0009071)3.63084690
49phospholipid efflux (GO:0033700)3.62226383
50flavonoid metabolic process (GO:0009812)3.58676858
51bile acid and bile salt transport (GO:0015721)3.56664915
52bile acid metabolic process (GO:0008206)3.54727752
53primary alcohol catabolic process (GO:0034310)3.52505184
54regulation of apoptotic process involved in morphogenesis (GO:1902337)3.52360297
55adhesion of symbiont to host (GO:0044406)3.51988125
56regulation of cholesterol homeostasis (GO:2000188)3.50316937
57triglyceride homeostasis (GO:0070328)3.48959339
58acylglycerol homeostasis (GO:0055090)3.48959339
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.47090742
60adhesion of symbiont to host cell (GO:0044650)3.46821959
61virion attachment to host cell (GO:0019062)3.46821959
62lipoprotein metabolic process (GO:0042157)3.44175172
63positive regulation of fatty acid beta-oxidation (GO:0032000)3.38388630
64glucuronate metabolic process (GO:0019585)3.38267282
65uronic acid metabolic process (GO:0006063)3.38267282
66endothelial cell chemotaxis (GO:0035767)3.35533573
67ethanol oxidation (GO:0006069)3.33801433
68fibrinolysis (GO:0042730)3.32742222
69drug catabolic process (GO:0042737)3.32500437
70aromatic amino acid family metabolic process (GO:0009072)3.31622667
71positive regulation of lipid catabolic process (GO:0050996)3.26207820
72carnitine metabolic process (GO:0009437)3.22814162
73low-density lipoprotein particle clearance (GO:0034383)3.22418487
74positive regulation of lipoprotein lipase activity (GO:0051006)3.22073726
75positive regulation of triglyceride lipase activity (GO:0061365)3.22073726
76alpha-amino acid catabolic process (GO:1901606)3.21810600
77tyrosine metabolic process (GO:0006570)3.21104868
78hormone catabolic process (GO:0042447)3.20570991
79interleukin-1-mediated signaling pathway (GO:0070498)3.19642798
80drug metabolic process (GO:0017144)3.19105340
81response to nitrosative stress (GO:0051409)3.18766044
82skin morphogenesis (GO:0043589)3.17743495
83xenobiotic catabolic process (GO:0042178)3.17417302
84cellular amino acid catabolic process (GO:0009063)3.16593400
85valine metabolic process (GO:0006573)3.16536955
86basement membrane organization (GO:0071711)3.16122559
87fatty acid beta-oxidation (GO:0006635)3.16073686
88cholesterol homeostasis (GO:0042632)3.14562841
89cellular ketone body metabolic process (GO:0046950)3.14023871
90endosome to pigment granule transport (GO:0043485)3.13723520
91endosome to melanosome transport (GO:0035646)3.13723520
92regulation of plasminogen activation (GO:0010755)3.12220649
93sterol homeostasis (GO:0055092)3.11787689
94fatty acid oxidation (GO:0019395)3.10691008
95phospholipid homeostasis (GO:0055091)3.09654358
96negative regulation of leukocyte chemotaxis (GO:0002689)3.08366617
97positive regulation of triglyceride metabolic process (GO:0090208)3.07243276
98cofactor catabolic process (GO:0051187)3.06257514
99benzene-containing compound metabolic process (GO:0042537)3.06217762
100cholesterol efflux (GO:0033344)3.04633368
101regulation of fatty acid beta-oxidation (GO:0031998)3.04467512
102lipid oxidation (GO:0034440)3.04150206
103serine family amino acid metabolic process (GO:0009069)3.03399686
104negative regulation of fatty acid transport (GO:2000192)3.02431695
105regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.02399753
106glycine metabolic process (GO:0006544)3.01961318
107regulation of cholesterol metabolic process (GO:0090181)3.00951833
108plasma lipoprotein particle assembly (GO:0034377)2.99501533
109positive regulation of Cdc42 GTPase activity (GO:0043089)2.98971451
110acute-phase response (GO:0006953)2.98160487
111aldehyde catabolic process (GO:0046185)2.97925329
112short-chain fatty acid metabolic process (GO:0046459)2.96088873
113mannose metabolic process (GO:0006013)2.94745015
114ethanol metabolic process (GO:0006067)2.91661050
115positive regulation of fatty acid oxidation (GO:0046321)2.91307839
116exogenous drug catabolic process (GO:0042738)2.90881983
117cell-substrate junction assembly (GO:0007044)2.89782770
118low-density lipoprotein particle remodeling (GO:0034374)2.89526035
119fatty acid catabolic process (GO:0009062)2.88517249
120iron ion import (GO:0097286)2.84456253
121type B pancreatic cell proliferation (GO:0044342)2.78216244
122macroautophagy (GO:0016236)2.77095685
123renal filtration (GO:0097205)2.76310224
124amyloid precursor protein catabolic process (GO:0042987)2.69038393
125positive regulation of histone deacetylation (GO:0031065)2.68170460
126regulation of water loss via skin (GO:0033561)2.58513730
127endodermal cell differentiation (GO:0035987)2.57157783
128semaphorin-plexin signaling pathway (GO:0071526)2.55685650
129vascular endothelial growth factor signaling pathway (GO:0038084)2.54360907
130cell adhesion mediated by integrin (GO:0033627)2.47009354
131barbed-end actin filament capping (GO:0051016)2.46903399
132hyaluronan catabolic process (GO:0030214)2.46264399
133cellular response to exogenous dsRNA (GO:0071360)2.45686861
134protein heterotrimerization (GO:0070208)2.44849144
135positive regulation of triglyceride biosynthetic process (GO:0010867)2.43043327
136regulation of integrin activation (GO:0033623)2.42651017
137endocardial cushion development (GO:0003197)2.38872727
138regulation of membrane protein ectodomain proteolysis (GO:0051043)2.38330517
139protein retention in ER lumen (GO:0006621)2.37817573
140positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37116485
141lung vasculature development (GO:0060426)2.36585742
142regulation of histone phosphorylation (GO:0033127)2.35409898
143negative regulation of viral entry into host cell (GO:0046597)2.29618900
144protein localization to endosome (GO:0036010)2.28680160
145negative regulation of protein autophosphorylation (GO:0031953)2.26768493
146cell-cell junction maintenance (GO:0045217)2.26614294
147negative regulation of viral release from host cell (GO:1902187)2.25230202
148endothelial cell morphogenesis (GO:0001886)2.24966217
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.23337353
150regulation of viral release from host cell (GO:1902186)2.23050697
151glomerular filtration (GO:0003094)2.21866860
152endosome organization (GO:0007032)2.21807670
153oligosaccharide catabolic process (GO:0009313)2.21178197
154sequestering of extracellular ligand from receptor (GO:0035581)2.19147815
155regulation of triglyceride biosynthetic process (GO:0010866)2.18676690
156establishment of skin barrier (GO:0061436)2.16030052
157keratinocyte proliferation (GO:0043616)2.14819427
158keratan sulfate catabolic process (GO:0042340)2.11594132
159branching involved in mammary gland duct morphogenesis (GO:0060444)2.10726356
160GDP-mannose metabolic process (GO:0019673)2.10343094
161extracellular matrix disassembly (GO:0022617)2.09816107
162negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.08934690
163response to progesterone (GO:0032570)2.07794160
164negative regulation of protein tyrosine kinase activity (GO:0061099)2.07780793
165activation of Rac GTPase activity (GO:0032863)2.07758593
166atrioventricular valve morphogenesis (GO:0003181)2.07102335
167glycosphingolipid catabolic process (GO:0046479)2.06988755
168cyclooxygenase pathway (GO:0019371)2.06850229
169positive regulation of osteoblast proliferation (GO:0033690)2.06456833
170positive regulation of CREB transcription factor activity (GO:0032793)2.04188585
171apoptotic cell clearance (GO:0043277)2.03771242
172regulation of endothelial cell chemotaxis (GO:2001026)2.03764953
173glutathione biosynthetic process (GO:0006750)2.03338775
174bundle of His cell to Purkinje myocyte communication (GO:0086069)2.01302525
175positive regulation of receptor recycling (GO:0001921)2.00639970
176regulation of interleukin-8 secretion (GO:2000482)2.00504201
177regulation of extracellular matrix disassembly (GO:0010715)1.99875641
178protein hydroxylation (GO:0018126)1.99259938
179regulation of early endosome to late endosome transport (GO:2000641)1.99018784
180multicellular organismal water homeostasis (GO:0050891)1.98818599
181diaphragm development (GO:0060539)1.98217464
182vascular endothelial growth factor receptor signaling pathway (GO:0048010)1.97108969
183negative regulation of tumor necrosis factor production (GO:0032720)1.96848012
184negative regulation of interleukin-8 production (GO:0032717)1.96566275
185tooth mineralization (GO:0034505)1.96177945
186regulation of vitamin metabolic process (GO:0030656)1.95664086
187lysosome organization (GO:0007040)1.95069398
188lytic vacuole organization (GO:0080171)1.95069398
189dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.94818877
190glycolipid catabolic process (GO:0019377)1.94648424
191regulation of integrin-mediated signaling pathway (GO:2001044)1.94543962
192calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)1.94501153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.98104920
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.73528755
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.27593763
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.18501541
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.48707845
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.91917013
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.69057798
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.31576442
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.09505390
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77973516
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77558990
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56857401
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55882516
14CLOCK_20551151_ChIP-Seq_293T_Human2.54154464
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.23759716
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.11612484
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.10132366
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99815590
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95392435
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.90244733
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89353326
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74261100
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63768485
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.62435738
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.61857235
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60828607
27VDR_21846776_ChIP-Seq_THP-1_Human1.59277705
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.58896204
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58665468
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58194445
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55530970
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.55254105
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50889677
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.48648370
35* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46103553
36* TP53_22127205_ChIP-Seq_IMR90_Human1.45974197
37LXR_22292898_ChIP-Seq_THP-1_Human1.44924785
38P68_20966046_ChIP-Seq_HELA_Human1.44764173
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44761981
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.43022823
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42314876
42RACK7_27058665_Chip-Seq_MCF-7_Human1.41838086
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39342433
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37894722
45JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35991172
46TP63_22573176_ChIP-Seq_HFKS_Human1.35647176
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34666825
48* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33202909
49BCOR_27268052_Chip-Seq_Bcells_Human1.32720194
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31159436
51GATA4_25053715_ChIP-Seq_YYC3_Human1.28502955
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.28306190
53* SMC4_20622854_ChIP-Seq_HELA_Human1.28091249
54BCL6_27268052_Chip-Seq_Bcells_Human1.27536703
55VDR_24763502_ChIP-Seq_THP-1_Human1.25911693
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25112867
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.22331492
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.19603496
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18756210
60* UBF1/2_26484160_Chip-Seq_HMECs_Human1.18449954
61KLF5_25053715_ChIP-Seq_YYC3_Human1.18317128
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18098144
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.17953405
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17880133
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17094287
66ATF3_27146783_Chip-Seq_COLON_Human1.17065946
67SOX2_20726797_ChIP-Seq_SW620_Human1.16963939
68E2F1_20622854_ChIP-Seq_HELA_Human1.16496625
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16255554
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15871181
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14383893
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14383893
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14383893
74* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13451238
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12989835
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12883561
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12213973
78KDM2B_26808549_Chip-Seq_K562_Human1.11654322
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11217689
80CREB1_26743006_Chip-Seq_LNCaP_Human1.10311949
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10204909
82GATA6_25053715_ChIP-Seq_YYC3_Human1.09883253
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09212301
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08923942
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.08483731
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07586958
87CJUN_26792858_Chip-Seq_BT549_Human1.07523021
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.07230799
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07175843
90CTCF_27219007_Chip-Seq_Bcells_Human1.06719092
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04863683
92KDM2B_26808549_Chip-Seq_DND41_Human1.03501242
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03383068
94SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02910971
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02214474
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01094801
97PHF8_20622854_ChIP-Seq_HELA_Human1.00628248
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99847663
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99526455
100HNF4A_19822575_ChIP-Seq_HepG2_Human0.98907254
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98410691
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98368450
103CTCF_20526341_ChIP-Seq_ESCs_Human0.98014826
104TP53_23651856_ChIP-Seq_MEFs_Mouse0.98000095
105RARB_24833708_ChIP-Seq_LIVER_Mouse0.97659458
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.97486340
107* SA1_27219007_Chip-Seq_Bcells_Human0.96883806
108* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96382600
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95656115
110STAT1_20625510_ChIP-Seq_HELA_Human0.95279505
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94816007
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93800704
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93114423
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92584769
115GATA1_19941826_ChIP-Seq_K562_Human0.91557136
116NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91390763
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91136662
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90813749
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90375279
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86680807
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86210520
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85760015
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84200912
124ZNF263_19887448_ChIP-Seq_K562_Human0.83722539
125GATA1_22025678_ChIP-Seq_K562_Human0.81286022
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81261296
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79901326
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79901326
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78468802
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.78209911
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.77550594
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.77550594
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77543701
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76538224
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76538224
136TCF7_22412390_ChIP-Seq_EML_Mouse0.75897531
137NCOR1_26117541_ChIP-Seq_K562_Human0.75359799
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73179667
139* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73030956
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71067089
141IRF8_27001747_Chip-Seq_BMDM_Mouse0.70853744
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.69601191
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69034721
144EGR1_19374776_ChIP-ChIP_THP-1_Human0.68885900
145CTCF_21964334_Chip-Seq_Bcells_Human0.68862889
146* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68656584
147JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68599739
148BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67841908
149* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.67785982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.56854951
2MP0002139_abnormal_hepatobiliary_system5.53805985
3MP0005085_abnormal_gallbladder_physiolo4.32044719
4MP0005365_abnormal_bile_salt4.19900495
5MP0008875_abnormal_xenobiotic_pharmacok3.65684000
6MP0003705_abnormal_hypodermis_morpholog3.49183588
7MP0003252_abnormal_bile_duct3.01630107
8MP0009840_abnormal_foam_cell2.92415332
9MP0008438_abnormal_cutaneous_collagen2.69836884
10MP0010329_abnormal_lipoprotein_level2.68497817
11MP0003806_abnormal_nucleotide_metabolis2.67164929
12MP0003191_abnormal_cellular_cholesterol2.65876552
13MP0004858_abnormal_nervous_system2.48503302
14MP0005083_abnormal_biliary_tract2.31684805
15MP0001666_abnormal_nutrient_absorption2.15757025
16MP0005332_abnormal_amino_acid2.04190681
17MP0010368_abnormal_lymphatic_system1.83102787
18MP0002254_reproductive_system_inflammat1.82270331
19MP0003011_delayed_dark_adaptation1.76852089
20MP0000609_abnormal_liver_physiology1.76507324
21MP0004019_abnormal_vitamin_homeostasis1.74998404
22MP0005319_abnormal_enzyme/_coenzyme1.64923602
23MP0005275_abnormal_skin_tensile1.63623722
24MP0005076_abnormal_cell_differentiation1.60413915
25MP0002118_abnormal_lipid_homeostasis1.56726211
26MP0010234_abnormal_vibrissa_follicle1.53658323
27MP0003195_calcinosis1.52237259
28MP0003172_abnormal_lysosome_physiology1.52002066
29MP0000013_abnormal_adipose_tissue1.39861134
30MP0009643_abnormal_urine_homeostasis1.38471979
31MP0002138_abnormal_hepatobiliary_system1.37101585
32MP0005023_abnormal_wound_healing1.34238796
33MP0000467_abnormal_esophagus_morphology1.32215697
34MP0001542_abnormal_bone_strength1.31314044
35MP0004272_abnormal_basement_membrane1.31278179
36MP0000579_abnormal_nail_morphology1.30989219
37MP0003300_gastrointestinal_ulcer1.25795276
38MP0002998_abnormal_bone_remodeling1.25214315
39MP0001873_stomach_inflammation1.24511236
40MP0003279_aneurysm1.24128258
41MP0003186_abnormal_redox_activity1.23744691
42MP0002933_joint_inflammation1.23553754
43MP0001216_abnormal_epidermal_layer1.22044575
44MP0003091_abnormal_cell_migration1.21968133
45MP0004264_abnormal_extraembryonic_tissu1.21485599
46MP0005595_abnormal_vascular_smooth1.21312200
47MP0005257_abnormal_intraocular_pressure1.20681410
48MP0003566_abnormal_cell_adhesion1.20129115
49MP0000678_abnormal_parathyroid_gland1.19393105
50MP0003950_abnormal_plasma_membrane1.16742799
51MP0001958_emphysema1.15132324
52MP0002896_abnormal_bone_mineralization1.12787139
53MP0002148_abnormal_hypersensitivity_rea1.11950481
54MP0002060_abnormal_skin_morphology1.11822991
55MP0003045_fibrosis1.10439875
56MP0004510_myositis1.10405813
57MP0000003_abnormal_adipose_tissue1.10266454
58MP0000598_abnormal_liver_morphology1.10213661
59MP0003868_abnormal_feces_composition1.08648404
60MP0005584_abnormal_enzyme/coenzyme_acti1.08484570
61MP0003828_pulmonary_edema1.06397404
62MP0000538_abnormal_urinary_bladder1.06049528
63MP0005670_abnormal_white_adipose1.05535091
64MP0003879_abnormal_hair_cell1.02679728
65MP0010352_gastrointestinal_tract_polyps1.02025562
66MP0002419_abnormal_innate_immunity1.00799511
67MP0003436_decreased_susceptibility_to1.00538084
68MP0002098_abnormal_vibrissa_morphology1.00400067
69MP0003183_abnormal_peptide_metabolism0.99038813
70MP0009764_decreased_sensitivity_to0.96866433
71MP0009384_cardiac_valve_regurgitation0.96488974
72MP0003724_increased_susceptibility_to0.95377530
73MP0000750_abnormal_muscle_regeneration0.93005829
74MP0005409_darkened_coat_color0.92698641
75MP0006054_spinal_hemorrhage0.92273986
76MP0009780_abnormal_chondrocyte_physiolo0.91084280
77MP0010771_integument_phenotype0.90523739
78MP0003453_abnormal_keratinocyte_physiol0.89351876
79MP0005058_abnormal_lysosome_morphology0.88517952
80MP0005501_abnormal_skin_physiology0.87911751
81MP0000383_abnormal_hair_follicle0.86594943
82MP0009053_abnormal_anal_canal0.84257105
83MP0001243_abnormal_dermal_layer0.84230434
84MP0004782_abnormal_surfactant_physiolog0.83958674
85MP0002796_impaired_skin_barrier0.83823969
86MP0009763_increased_sensitivity_to0.83626676
87MP0006082_CNS_inflammation0.83425637
88MP0009931_abnormal_skin_appearance0.82764760
89MP0000762_abnormal_tongue_morphology0.82579192
90MP0005666_abnormal_adipose_tissue0.81650052
91* MP0008469_abnormal_protein_level0.81507455
92MP0001348_abnormal_lacrimal_gland0.81383617
93* MP0005025_abnormal_response_to0.80970267
94MP0004043_abnormal_pH_regulation0.80035557
95MP0001765_abnormal_ion_homeostasis0.79837503
96MP0004233_abnormal_muscle_weight0.79778641
97MP0005503_abnormal_tendon_morphology0.79558972
98MP0005375_adipose_tissue_phenotype0.78789580
99MP0001756_abnormal_urination0.77551114
100MP0000470_abnormal_stomach_morphology0.77175115
101MP0000343_altered_response_to0.76781417
102MP0005451_abnormal_body_composition0.75339502
103MP0002136_abnormal_kidney_physiology0.75291387
104MP0002295_abnormal_pulmonary_circulatio0.74183531
105MP0000249_abnormal_blood_vessel0.71137387
106MP0001533_abnormal_skeleton_physiology0.70821793
107MP0001764_abnormal_homeostasis0.70587886
108MP0005164_abnormal_response_to0.70551582
109MP0004185_abnormal_adipocyte_glucose0.70164520
110MP0005084_abnormal_gallbladder_morpholo0.69322131
111MP0002971_abnormal_brown_adipose0.69312900
112MP0003303_peritoneal_inflammation0.68822926
113MP0004130_abnormal_muscle_cell0.68706990
114MP0005636_abnormal_mineral_homeostasis0.68591814
115MP0010030_abnormal_orbit_morphology0.67057324
116MP0005167_abnormal_blood-brain_barrier0.66287963
117MP0009642_abnormal_blood_homeostasis0.65863529
118MP0002132_abnormal_respiratory_system0.65083750
119MP0005464_abnormal_platelet_physiology0.64390801
120MP0005220_abnormal_exocrine_pancreas0.63181142
121MP0005376_homeostasis/metabolism_phenot0.63159616
122MP0009115_abnormal_fat_cell0.62810014
123MP0000767_abnormal_smooth_muscle0.62762521
124MP0004883_abnormal_blood_vessel0.62717822
125MP0004947_skin_inflammation0.62417863
126MP0003075_altered_response_to0.60522298
127MP0001849_ear_inflammation0.59160033
128MP0010155_abnormal_intestine_physiology0.58517801
129MP0000604_amyloidosis0.56009438
130MP0005508_abnormal_skeleton_morphology0.54925723
131MP0005248_abnormal_Harderian_gland0.54556339
132MP0003656_abnormal_erythrocyte_physiolo0.54410898
133MP0005334_abnormal_fat_pad0.53829112
134MP0000858_altered_metastatic_potential0.53568830
135MP0002135_abnormal_kidney_morphology0.52600768
136MP0005165_increased_susceptibility_to0.52221054
137MP0005408_hypopigmentation0.51966680
138MP0005390_skeleton_phenotype0.51602944
139MP0001879_abnormal_lymphatic_vessel0.50989980
140MP0002877_abnormal_melanocyte_morpholog0.50852542
141MP0002168_other_aberrant_phenotype0.49485129

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.57956574
2Xanthomatosis (HP:0000991)4.97175437
3Intrahepatic cholestasis (HP:0001406)4.80772674
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.80129995
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.68526689
6Complement deficiency (HP:0004431)4.09021209
7Hypobetalipoproteinemia (HP:0003563)4.00747880
8Abnormality of glycolipid metabolism (HP:0010969)3.84913518
9Abnormality of liposaccharide metabolism (HP:0010968)3.84913518
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.84913518
11Prolonged partial thromboplastin time (HP:0003645)3.84199406
12Protrusio acetabuli (HP:0003179)3.79841528
13Hyperlipoproteinemia (HP:0010980)3.75277424
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.60148852
15Atrophic scars (HP:0001075)3.59731177
16Abnormality of the intrinsic pathway (HP:0010989)3.48980351
17Hypolipoproteinemia (HP:0010981)3.48860761
18Hypoalphalipoproteinemia (HP:0003233)3.47213082
19Peritonitis (HP:0002586)3.46618830
20Hyperammonemia (HP:0001987)3.44883196
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.43349961
22Abnormality of complement system (HP:0005339)3.39803917
23Joint hemorrhage (HP:0005261)3.39409418
24Increased cerebral lipofuscin (HP:0011813)3.34494130
25Abnormality of the common coagulation pathway (HP:0010990)3.28118838
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.22286621
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.20317117
28Ketosis (HP:0001946)3.20250295
29Hyperglycinuria (HP:0003108)3.17150767
30Cervical subluxation (HP:0003308)3.13711177
31Hypoglycemic coma (HP:0001325)3.01143049
32Dysostosis multiplex (HP:0000943)2.98389932
33Abnormality of serine family amino acid metabolism (HP:0010894)2.94596853
34Abnormality of glycine metabolism (HP:0010895)2.94596853
35Premature rupture of membranes (HP:0001788)2.93675599
36Fragile skin (HP:0001030)2.91530757
37Epidermoid cyst (HP:0200040)2.90486371
38Hypercholesterolemia (HP:0003124)2.89306939
39Myocardial infarction (HP:0001658)2.88947661
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.88261123
41Malnutrition (HP:0004395)2.86435562
42Alopecia of scalp (HP:0002293)2.83745513
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83538065
44Abnormality of polysaccharide metabolism (HP:0011012)2.83538065
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83538065
46Abnormal cartilage morphology (HP:0002763)2.82098833
47Fat malabsorption (HP:0002630)2.79841764
48Milia (HP:0001056)2.78343174
49Systemic lupus erythematosus (HP:0002725)2.78297887
50Abnormality of fatty-acid metabolism (HP:0004359)2.77379193
51Urinary glycosaminoglycan excretion (HP:0003541)2.75127332
52Mucopolysacchariduria (HP:0008155)2.75127332
53Follicular hyperkeratosis (HP:0007502)2.69737186
54Skin nodule (HP:0200036)2.68938722
55Hyperacusis (HP:0010780)2.66700656
56Hyperglycinemia (HP:0002154)2.65693997
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65326580
58Joint stiffness (HP:0001387)2.60790651
59Esophageal varix (HP:0002040)2.60093620
60Bladder diverticulum (HP:0000015)2.57979044
61Plantar hyperkeratosis (HP:0007556)2.55476427
62Abnormality of purine metabolism (HP:0004352)2.54377434
63Cardiovascular calcification (HP:0011915)2.53786215
64Vacuolated lymphocytes (HP:0001922)2.52947497
65Ketoacidosis (HP:0001993)2.52697190
66Amyloidosis (HP:0011034)2.51801722
67Vascular calcification (HP:0004934)2.48226831
68Broad face (HP:0000283)2.45519480
69Abnormality of the Achilles tendon (HP:0005109)2.44742755
70Gout (HP:0001997)2.44065127
71Abnormality of nucleobase metabolism (HP:0010932)2.42660427
72J-shaped sella turcica (HP:0002680)2.42659770
73Cheilitis (HP:0100825)2.40794645
74Hepatocellular carcinoma (HP:0001402)2.39461870
75Increased connective tissue (HP:0009025)2.38822180
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38052560
77Focal segmental glomerulosclerosis (HP:0000097)2.34442687
78Right ventricular cardiomyopathy (HP:0011663)2.32172509
79Thin bony cortex (HP:0002753)2.31173430
80Coxa vara (HP:0002812)2.30676283
81Natal tooth (HP:0000695)2.29176304
82Abnormality of methionine metabolism (HP:0010901)2.26233315
83Dicarboxylic aciduria (HP:0003215)2.24550822
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24550822
85Short nail (HP:0001799)2.23459066
86Hydroxyprolinuria (HP:0003080)2.22906944
87Abnormality of proline metabolism (HP:0010907)2.22906944
88Fragile nails (HP:0001808)2.22334412
89Abnormality of pyrimidine metabolism (HP:0004353)2.19226411
90Broad metatarsal (HP:0001783)2.19119314
91Spastic diplegia (HP:0001264)2.19094143
92Hyperbilirubinemia (HP:0002904)2.18333256
93Hypochromic microcytic anemia (HP:0004840)2.17857421
94Glomerulonephritis (HP:0000099)2.13463166
95Thick nail (HP:0001805)2.13102707
96Elbow flexion contracture (HP:0002987)2.11235531
97Palmoplantar hyperkeratosis (HP:0000972)2.04704955
98Multiple enchondromatosis (HP:0005701)2.02966174
99Ovoid vertebral bodies (HP:0003300)2.02640802
100Nonimmune hydrops fetalis (HP:0001790)2.02509954
101Vascular tortuosity (HP:0004948)2.02163417
102Onycholysis (HP:0001806)2.01879900
103Metabolic acidosis (HP:0001942)2.01703105
104Steatorrhea (HP:0002570)2.01193574
105Aortic aneurysm (HP:0004942)2.01104039
106Aortic dissection (HP:0002647)1.99822164
107Achilles tendon contracture (HP:0001771)1.99716024
108Polycythemia (HP:0001901)1.99347303
109Mitral stenosis (HP:0001718)1.98694709
110Amelogenesis imperfecta (HP:0000705)1.98435600
111Nail dystrophy (HP:0008404)1.97772001
112Delayed CNS myelination (HP:0002188)1.97023084
113Lymphangioma (HP:0100764)1.96771887
114Abnormal hair laboratory examination (HP:0003328)1.95786746
115Hemorrhage of the eye (HP:0011885)1.95349932
116Nephritis (HP:0000123)1.94472243
117Breast hypoplasia (HP:0003187)1.94071655
118Glomerulosclerosis (HP:0000096)1.93581160
119Cardiomegaly (HP:0001640)1.92942797
120Ankle contracture (HP:0006466)1.92908645
121Gingival bleeding (HP:0000225)1.91886901
122Spontaneous abortion (HP:0005268)1.91615160
123Conjugated hyperbilirubinemia (HP:0002908)1.90633179
124Spondylolisthesis (HP:0003302)1.89760603
125Abnormality of iron homeostasis (HP:0011031)1.89615093
126Wormian bones (HP:0002645)1.89305772
127Cerebral aneurysm (HP:0004944)1.88070278
128Protuberant abdomen (HP:0001538)1.87791718
129Flat acetabular roof (HP:0003180)1.85770750
130Generalized aminoaciduria (HP:0002909)1.85369296
131Vertebral compression fractures (HP:0002953)1.85014217
132Mildly elevated creatine phosphokinase (HP:0008180)1.84564584
133Recurrent gram-negative bacterial infections (HP:0005420)1.83364456
134Prolonged neonatal jaundice (HP:0006579)1.82918669
135Aneurysm (HP:0002617)1.82844467
136Hepatoblastoma (HP:0002884)1.82740292
137Menorrhagia (HP:0000132)1.82593367
138Abnormality of transition element cation homeostasis (HP:0011030)1.82469929
139Late onset (HP:0003584)1.80897855
140Mitral valve prolapse (HP:0001634)1.80783396
141Abnormal tarsal ossification (HP:0008369)1.80167555
142Interstitial pulmonary disease (HP:0006530)1.78980174
143Distal lower limb muscle weakness (HP:0009053)1.78275890
144Ectopia lentis (HP:0001083)1.77915727
145Upper limb amyotrophy (HP:0009129)1.77444241
146Distal upper limb amyotrophy (HP:0007149)1.77444241
147Pancreatitis (HP:0001733)1.76619897
148Abdominal distention (HP:0003270)1.76413251
149Increased serum ferritin (HP:0003281)1.76254385
150Abnormal enzyme/coenzyme activity (HP:0012379)1.76177331
151Arterial tortuosity (HP:0005116)1.74841819
152Long toe (HP:0010511)1.74669744
153Abnormal delivery (HP:0001787)1.74135630
154Spinal rigidity (HP:0003306)1.73659973
155Polygenic inheritance (HP:0010982)1.73451820
156Axonal loss (HP:0003447)1.73432913
157Blue sclerae (HP:0000592)1.72962057
158Abnormal blistering of the skin (HP:0008066)1.72807772
159Asymmetric septal hypertrophy (HP:0001670)1.72371892
160Shallow orbits (HP:0000586)1.70831868
161Palmar hyperkeratosis (HP:0010765)1.70718247
162Elevated erythrocyte sedimentation rate (HP:0003565)1.70598260
163Soft skin (HP:0000977)1.70551155
164Bradycardia (HP:0001662)1.69848012
165Femoral bowing (HP:0002980)1.69531721
166Loss of speech (HP:0002371)1.68986771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.03249833
2TRIB33.85487224
3BCKDK3.25725182
4PKN22.93639448
5SIK12.83307349
6TGFBR22.62521159
7MST1R2.35922214
8FGFR42.22797864
9RIPK12.11374435
10TTN1.84279503
11PTK61.74592436
12KDR1.65303040
13PRKD21.63663730
14ICK1.62396134
15GRK61.61613424
16PRKG21.52594459
17PAK41.51872867
18CDK121.47733399
19MAP2K31.42322521
20TBK11.42267035
21MAP3K31.41356709
22CDC42BPA1.40248511
23EPHB11.39973590
24EPHB21.38727205
25FLT31.37118113
26PDGFRA1.35489863
27TIE11.35326432
28MYLK1.34651187
29MAP3K101.31721124
30LRRK21.30679477
31CSF1R1.29660668
32EPHA21.26100004
33LATS11.25443571
34SMG11.22289099
35NEK91.20948806
36ADRBK21.20274433
37PTK21.18631133
38ACVR1B1.17623934
39MET1.11987427
40WNK41.10294807
41DDR21.10200256
42LIMK11.09491177
43BMX1.09165591
44PIK3CG1.08323396
45TAOK31.07604747
46STK381.07536467
47STK101.05964256
48TYK21.05426501
49MAP2K21.04644263
50PDPK11.02120795
51MATK1.01424996
52IRAK41.01411255
53ABL21.00069017
54ADRBK10.98312402
55NTRK10.98231267
56MAPK150.96346736
57MAP3K70.95465519
58MOS0.93431068
59RPS6KA20.92009127
60CSK0.88835767
61RPS6KA60.88435445
62KIT0.88190838
63FRK0.87019432
64TLK10.86804450
65ERBB40.86606749
66EPHA30.86547139
67PAK20.85707659
68PIK3CA0.84963449
69LMTK20.84106762
70MAP3K60.83651667
71FGFR30.82243515
72PIM20.80704709
73CAMK1D0.79234602
74GRK10.78604403
75MAPK70.77307941
76LATS20.74897915
77MAPK110.74549467
78PTK2B0.74144569
79PRKCI0.70496510
80PDGFRB0.68470816
81AKT30.68465266
82TAOK20.68172168
83JAK10.67473194
84CDK60.67325139
85MARK20.67111716
86EEF2K0.66169244
87TGFBR10.66096908
88RPS6KC10.65681575
89RPS6KL10.65681575
90JAK20.65237835
91HIPK20.64649686
92MAP3K10.63644076
93MAP3K110.63456635
94FER0.61211312
95MAP2K10.60814174
96IRAK30.60499881
97NME20.60498490
98MAPKAPK20.60425500
99MTOR0.59447266
100DYRK1B0.58835016
101GSK3A0.55567828
102IRAK10.54764567
103GRK50.53987466
104ERBB20.53912220
105BLK0.53408607
106MAPKAPK30.52581973
107TESK10.51679443
108INSRR0.51219396
109RPS6KA40.50674622
110PRKAA20.50483273
111MAPK40.48344678
112DAPK30.46266604
113ILK0.46068643
114GRK70.44373336
115ZAP700.44209826
116MAP2K60.43537803
117IGF1R0.42070014
118MAPK120.41726328
119MUSK0.41576976
120SCYL20.41499353
121STK30.40643532
122CAMK40.39800136
123PRKD30.37952817
124TAOK10.37248096
125MAP3K20.36281205
126MAP3K140.35475571
127IKBKB0.35299464
128STK38L0.35147705
129TTK0.34604069
130JAK30.34314532
131CHUK0.34198250
132RPS6KB20.33939316
133TRPM70.32646216

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58373007
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34069655
3Nitrogen metabolism_Homo sapiens_hsa009102.76524091
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.67211189
5Complement and coagulation cascades_Homo sapiens_hsa046102.61950553
6Fatty acid degradation_Homo sapiens_hsa000712.58184456
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56388784
8Tryptophan metabolism_Homo sapiens_hsa003802.49545349
9Arginine biosynthesis_Homo sapiens_hsa002202.49410824
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37804765
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29526800
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.26920884
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.19106614
14PPAR signaling pathway_Homo sapiens_hsa033202.11064310
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08333579
16Chemical carcinogenesis_Homo sapiens_hsa052042.07207220
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06601902
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00743245
19Caffeine metabolism_Homo sapiens_hsa002321.95670544
20Staphylococcus aureus infection_Homo sapiens_hsa051501.80484981
21Peroxisome_Homo sapiens_hsa041461.80350652
22Histidine metabolism_Homo sapiens_hsa003401.76457011
23Propanoate metabolism_Homo sapiens_hsa006401.76209513
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73623997
25Fatty acid metabolism_Homo sapiens_hsa012121.73216311
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68070484
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.65042787
28Sulfur metabolism_Homo sapiens_hsa009201.62089224
29Butanoate metabolism_Homo sapiens_hsa006501.61690505
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.55965427
31beta-Alanine metabolism_Homo sapiens_hsa004101.55566296
32Fat digestion and absorption_Homo sapiens_hsa049751.54904394
33Starch and sucrose metabolism_Homo sapiens_hsa005001.51810550
34Bile secretion_Homo sapiens_hsa049761.51497573
35Retinol metabolism_Homo sapiens_hsa008301.47342576
36Selenocompound metabolism_Homo sapiens_hsa004501.42833467
37Phenylalanine metabolism_Homo sapiens_hsa003601.36176488
38Sulfur relay system_Homo sapiens_hsa041221.33539182
39TNF signaling pathway_Homo sapiens_hsa046681.33246645
40Carbon metabolism_Homo sapiens_hsa012001.25882901
41Folate biosynthesis_Homo sapiens_hsa007901.25036563
42Pyruvate metabolism_Homo sapiens_hsa006201.21008835
43Tyrosine metabolism_Homo sapiens_hsa003501.18409922
44Toxoplasmosis_Homo sapiens_hsa051451.12225025
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09158274
46Biosynthesis of amino acids_Homo sapiens_hsa012301.09030883
47Sphingolipid metabolism_Homo sapiens_hsa006001.06886498
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06203181
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05323358
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02699647
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00973605
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00944828
53ABC transporters_Homo sapiens_hsa020101.00394062
54Galactose metabolism_Homo sapiens_hsa000520.97699047
55Glutathione metabolism_Homo sapiens_hsa004800.97571424
56Vitamin digestion and absorption_Homo sapiens_hsa049770.96704764
57Osteoclast differentiation_Homo sapiens_hsa043800.95209227
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.92462151
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91934203
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.90491770
61Arginine and proline metabolism_Homo sapiens_hsa003300.89717816
62Fructose and mannose metabolism_Homo sapiens_hsa000510.87434180
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83983951
64Pentose phosphate pathway_Homo sapiens_hsa000300.82071935
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80879881
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79305697
67Vitamin B6 metabolism_Homo sapiens_hsa007500.79114611
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.78794716
69Lysine degradation_Homo sapiens_hsa003100.78285868
70Fatty acid elongation_Homo sapiens_hsa000620.77939928
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76155942
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75795278
73Glycerolipid metabolism_Homo sapiens_hsa005610.75065037
74Ovarian steroidogenesis_Homo sapiens_hsa049130.74846149
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74630152
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70641032
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70362931
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.69748538
79Steroid biosynthesis_Homo sapiens_hsa001000.68411335
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66371781
81Acute myeloid leukemia_Homo sapiens_hsa052210.65066167
82Ether lipid metabolism_Homo sapiens_hsa005650.64975068
83Tuberculosis_Homo sapiens_hsa051520.64184403
84VEGF signaling pathway_Homo sapiens_hsa043700.63415592
85Notch signaling pathway_Homo sapiens_hsa043300.63061626
86African trypanosomiasis_Homo sapiens_hsa051430.56506307
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.55594037
88N-Glycan biosynthesis_Homo sapiens_hsa005100.55358533
89One carbon pool by folate_Homo sapiens_hsa006700.55339194
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54750407
91* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54116379
92Influenza A_Homo sapiens_hsa051640.53510750
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53323362
94ECM-receptor interaction_Homo sapiens_hsa045120.52199660
95* NF-kappa B signaling pathway_Homo sapiens_hsa040640.51908943
96Protein digestion and absorption_Homo sapiens_hsa049740.50544584
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.49846038
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49329994
99Bladder cancer_Homo sapiens_hsa052190.49314518
100Endocytosis_Homo sapiens_hsa041440.48974588
101Insulin resistance_Homo sapiens_hsa049310.48656641
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48365813
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47428737
104Other glycan degradation_Homo sapiens_hsa005110.47190816
105Phagosome_Homo sapiens_hsa041450.46686863
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46073693
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.41556045
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41425624
109Linoleic acid metabolism_Homo sapiens_hsa005910.40546689
110Apoptosis_Homo sapiens_hsa042100.38844344
111Rheumatoid arthritis_Homo sapiens_hsa053230.38685967
112Fatty acid biosynthesis_Homo sapiens_hsa000610.37066640
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36506857
114Arachidonic acid metabolism_Homo sapiens_hsa005900.35928803
115Metabolic pathways_Homo sapiens_hsa011000.35583383
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35560883
117Amoebiasis_Homo sapiens_hsa051460.33733255
118Renin-angiotensin system_Homo sapiens_hsa046140.33209960
119Malaria_Homo sapiens_hsa051440.32993055
120Prion diseases_Homo sapiens_hsa050200.31932857
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29104484
122Lysosome_Homo sapiens_hsa041420.28646424
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25230608
124Focal adhesion_Homo sapiens_hsa045100.24709157
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20742403
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.20005354
127Pertussis_Homo sapiens_hsa051330.19885655
128Mineral absorption_Homo sapiens_hsa049780.18314043
129AMPK signaling pathway_Homo sapiens_hsa041520.16990830
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16716158
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.16398719
132Small cell lung cancer_Homo sapiens_hsa052220.14859060
133Proteoglycans in cancer_Homo sapiens_hsa052050.14553605
134Hepatitis C_Homo sapiens_hsa051600.13434521
135Legionellosis_Homo sapiens_hsa051340.11695415
136Leishmaniasis_Homo sapiens_hsa051400.10818215

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