LTK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.03309717
2polyketide metabolic process (GO:0030638)9.03309717
3doxorubicin metabolic process (GO:0044598)9.03309717
4maintenance of protein location in nucleus (GO:0051457)6.45529186
5aminoglycoside antibiotic metabolic process (GO:0030647)5.75758651
6negative regulation of cell killing (GO:0031342)5.74840123
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.74840123
8positive regulation of gamma-delta T cell activation (GO:0046645)5.69926013
9somite rostral/caudal axis specification (GO:0032525)5.63682314
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59007572
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.56534837
12regulation of response to osmotic stress (GO:0047484)5.55906172
13regulation of cilium movement (GO:0003352)5.53771560
14antigen processing and presentation of endogenous antigen (GO:0019883)5.45856856
15regulation of mammary gland epithelial cell proliferation (GO:0033599)5.43071229
16synaptic vesicle maturation (GO:0016188)5.41320774
17histone H4-K5 acetylation (GO:0043981)5.29112234
18histone H4-K8 acetylation (GO:0043982)5.29112234
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.16669473
20negative regulation of epidermis development (GO:0045683)5.13024881
21proline transport (GO:0015824)5.10995269
22regulation of MHC class I biosynthetic process (GO:0045343)5.08885403
23negative regulation of erythrocyte differentiation (GO:0045647)5.02747544
24negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.93860442
25histone H4-K12 acetylation (GO:0043983)4.93707634
26negative regulation of telomerase activity (GO:0051974)4.66639577
27muscle organ morphogenesis (GO:0048644)4.62586641
28response to dietary excess (GO:0002021)4.60497818
29regulation of telomere maintenance via telomerase (GO:0032210)4.54071232
30neutrophil activation involved in immune response (GO:0002283)4.48010031
31protein polyglutamylation (GO:0018095)4.43681111
32phenol-containing compound catabolic process (GO:0019336)4.41277750
33regulation of nuclear cell cycle DNA replication (GO:0033262)4.36847388
34negative regulation of cell cycle G2/M phase transition (GO:1902750)4.36437286
35cytidine metabolic process (GO:0046087)4.34738796
36cytidine catabolic process (GO:0006216)4.34738796
37cytidine deamination (GO:0009972)4.34738796
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.30765005
39rRNA transcription (GO:0009303)4.29077081
40regulation of B cell receptor signaling pathway (GO:0050855)4.29063828
41positive thymic T cell selection (GO:0045059)4.27899969
42protein localization to kinetochore (GO:0034501)4.25072641
43mitochondrion distribution (GO:0048311)4.24989115
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.23502784
45microtubule severing (GO:0051013)4.23111289
46tachykinin receptor signaling pathway (GO:0007217)4.21855648
47histone H4-K16 acetylation (GO:0043984)4.21058869
48regulation of gamma-delta T cell differentiation (GO:0045586)4.14858257
49regulation of gamma-delta T cell activation (GO:0046643)4.13500350
50detection of bacterium (GO:0016045)4.13442706
51B cell receptor signaling pathway (GO:0050853)4.12353652
52detection of other organism (GO:0098543)4.09128373
53positive regulation by symbiont of host defense response (GO:0052509)4.05555177
54modulation by symbiont of host defense response (GO:0052031)4.05555177
55modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.05555177
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.05555177
57positive regulation by organism of defense response of other organism involved in symbiotic interact4.05555177
58modulation by symbiont of host immune response (GO:0052553)4.05555177
59glutamate secretion (GO:0014047)4.02948579
60positive regulation of B cell differentiation (GO:0045579)3.98592402
61negative thymic T cell selection (GO:0045060)3.97582649
62negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.96633793
63calcium-mediated signaling using intracellular calcium source (GO:0035584)3.96575508
64tolerance induction (GO:0002507)3.94983432
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.93798314
66leukocyte aggregation (GO:0070486)3.93633301
67mannose metabolic process (GO:0006013)3.89773222
68interferon-gamma production (GO:0032609)3.85892492
69heterochromatin organization (GO:0070828)3.85816981
70thymic T cell selection (GO:0045061)3.85132960
71negative regulation of epidermal cell differentiation (GO:0045605)3.82264738
72negative T cell selection (GO:0043383)3.82008739
73hormone catabolic process (GO:0042447)3.79508522
74mitotic sister chromatid segregation (GO:0000070)3.76264630
75response to peptidoglycan (GO:0032494)3.76186741
76regulation of mast cell degranulation (GO:0043304)3.76011803
77regulation of B cell differentiation (GO:0045577)3.72760545
78T cell selection (GO:0045058)3.71552775
79response to muramyl dipeptide (GO:0032495)3.64694743
80ventricular system development (GO:0021591)3.59774756
81notochord development (GO:0030903)3.58103830
82maintenance of protein localization in organelle (GO:0072595)3.56116622
83regulation of leukocyte degranulation (GO:0043300)3.55684478
84positive T cell selection (GO:0043368)3.53401422
85negative regulation of leukocyte mediated immunity (GO:0002704)3.52863637
86regulation of myeloid leukocyte mediated immunity (GO:0002886)3.50652499
87regulation of tolerance induction (GO:0002643)3.49600579
88protein localization to cilium (GO:0061512)3.48467809
89regulation of microtubule-based movement (GO:0060632)3.47434371
90positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47355702
91branching involved in mammary gland duct morphogenesis (GO:0060444)3.46859971
92cellular extravasation (GO:0045123)3.42774572
93negative regulation of T cell mediated immunity (GO:0002710)3.41194313
94regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41133666
95positive regulation of granulocyte differentiation (GO:0030854)3.38292463
96pyrimidine ribonucleoside catabolic process (GO:0046133)3.38098010
97regulation of mast cell activation involved in immune response (GO:0033006)3.34926202
98positive regulation of DNA-dependent DNA replication (GO:2000105)3.33543894
99neutrophil activation (GO:0042119)3.33308057
100synaptic vesicle docking involved in exocytosis (GO:0016081)3.31583987
101negative regulation of telomere maintenance (GO:0032205)3.30380946
102immunoglobulin mediated immune response (GO:0016064)3.28158910
103transepithelial transport (GO:0070633)3.27117958
104macrophage activation involved in immune response (GO:0002281)3.26274971
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.23759892
106nucleoside transmembrane transport (GO:1901642)3.22083052
107regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.21823505
108positive regulation of digestive system process (GO:0060456)3.21108796
109hypotonic response (GO:0006971)3.20147133
110primitive streak formation (GO:0090009)3.19453300
111positive regulation of tolerance induction (GO:0002645)3.18322422
112detection of temperature stimulus (GO:0016048)3.16713094
113locomotory exploration behavior (GO:0035641)3.15839668
114rRNA methylation (GO:0031167)3.14475065
115negative regulation of glycoprotein biosynthetic process (GO:0010561)3.14094314
116cellular modified amino acid catabolic process (GO:0042219)3.13196563
117intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.12609081
118respiratory burst (GO:0045730)3.12208022
119pre-miRNA processing (GO:0031054)3.11893477
120chromatin assembly (GO:0031497)3.10154957
121positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09267241
122coenzyme catabolic process (GO:0009109)3.09107275
123antigen processing and presentation via MHC class Ib (GO:0002475)3.08080143
124negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07882065
125synaptic vesicle exocytosis (GO:0016079)3.05813113
126quinone metabolic process (GO:1901661)3.05755378
127regulation of interferon-beta biosynthetic process (GO:0045357)3.05528436
128detection of external biotic stimulus (GO:0098581)3.03564757
129regulation of telomere maintenance (GO:0032204)3.03377532
130negative regulation of potassium ion transmembrane transport (GO:1901380)3.02442152
131sister chromatid segregation (GO:0000819)3.02266258
132cell fate commitment involved in formation of primary germ layer (GO:0060795)3.01772360
133cardiovascular system development (GO:0072358)3.01331723
134response to interleukin-15 (GO:0070672)3.00804217
135positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00098179
136positive regulation of Rap GTPase activity (GO:0032854)2.99594981
137regulation of apoptotic process involved in morphogenesis (GO:1902337)2.99147011
138T cell migration (GO:0072678)2.97120354
139regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.96871455
140regulation of Rap GTPase activity (GO:0032317)2.96656305
141negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.95631632
142positive regulation of protein deacetylation (GO:0090312)2.94870108
143granulocyte activation (GO:0036230)2.94473293
144positive regulation of synapse maturation (GO:0090129)2.93879624
145regulation of regulated secretory pathway (GO:1903305)2.91948489
146regulation of necroptotic process (GO:0060544)2.91236724
147regulation of telomerase activity (GO:0051972)2.90743190
148receptor recycling (GO:0001881)2.90457108
149negative regulation of interleukin-6 production (GO:0032715)2.90333788
150arachidonic acid secretion (GO:0050482)2.90262287
151icosanoid secretion (GO:0032309)2.90262287
152germinal center formation (GO:0002467)2.89961623
153negative regulation of phagocytosis (GO:0050765)2.89853807
154regulation of T cell tolerance induction (GO:0002664)2.89610026
155protein localization to chromosome, centromeric region (GO:0071459)2.88926115
156adaptation of signaling pathway (GO:0023058)2.87980515
157vocalization behavior (GO:0071625)2.87249640
158response to laminar fluid shear stress (GO:0034616)2.85737065
159apoptotic DNA fragmentation (GO:0006309)2.84524924
160negative regulation of interleukin-8 production (GO:0032717)2.83058896
161retinoic acid receptor signaling pathway (GO:0048384)2.82023204
162G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81165939
163Peyers patch development (GO:0048541)2.80694821
164mucosal-associated lymphoid tissue development (GO:0048537)2.80694821
165ovulation cycle (GO:0042698)2.77664585
166negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77374397
167response to type I interferon (GO:0034340)2.75993034
168type I interferon signaling pathway (GO:0060337)2.75240626
169cellular response to type I interferon (GO:0071357)2.75240626
170regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75059277
171melanosome transport (GO:0032402)2.74866530
172myeloid cell activation involved in immune response (GO:0002275)2.74739665
173antigen receptor-mediated signaling pathway (GO:0050851)2.74387164
174positive regulation of macrophage cytokine production (GO:0060907)2.73749701
175positive regulation of histone deacetylation (GO:0031065)2.73402978
176neurotransmitter secretion (GO:0007269)2.72836464
177negative regulation of innate immune response (GO:0045824)2.72196204
178regulation of mast cell activation (GO:0033003)2.70390354
179regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69872657
180Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67524144
181regulation of granulocyte differentiation (GO:0030852)2.67424313
1823-UTR-mediated mRNA stabilization (GO:0070935)2.66990813
183defense response to protozoan (GO:0042832)2.66975409
184detection of biotic stimulus (GO:0009595)2.65833730
185positive regulation of mast cell activation (GO:0033005)2.65326427
186actin filament polymerization (GO:0030041)2.65303082
187negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65190381
188phospholipid scrambling (GO:0017121)2.64952921
189T cell homeostasis (GO:0043029)2.63207735
190neutrophil mediated immunity (GO:0002446)2.63203013
191leukocyte degranulation (GO:0043299)2.62907787
192axonemal dynein complex assembly (GO:0070286)2.62459571
193regulation of alpha-beta T cell proliferation (GO:0046640)2.60828008
194megakaryocyte development (GO:0035855)2.59714522
195negative regulation of toll-like receptor signaling pathway (GO:0034122)2.58556248
196histone H3-K36 demethylation (GO:0070544)2.58428476
197negative regulation of type 2 immune response (GO:0002829)2.58300478
198response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57688916
199response to host immune response (GO:0052572)2.57688916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.42008465
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.96162386
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.96162386
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.96162386
5VDR_21846776_ChIP-Seq_THP-1_Human3.75736457
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.57301901
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53637448
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.16702458
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.86593007
10VDR_24763502_ChIP-Seq_THP-1_Human2.83505925
11EZH2_22144423_ChIP-Seq_EOC_Human2.82927683
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79315093
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.68705478
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49702975
15MAF_26560356_Chip-Seq_TH1_Human2.49304789
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37692938
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37559922
18UTX_26944678_Chip-Seq_JUKART_Human2.36844349
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.35158063
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.31652024
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.29833733
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25854137
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.25136680
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.24769251
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20826760
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19605639
27TCF3_18692474_ChIP-Seq_MESCs_Mouse2.19422300
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15855315
29SPI1_23547873_ChIP-Seq_NB4_Human2.12599604
30KDM2B_26808549_Chip-Seq_DND41_Human2.10919774
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10754997
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07202292
33ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07129859
34SCL_19346495_ChIP-Seq_HPC-7_Human2.06518698
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06297556
36SPI1_23127762_ChIP-Seq_K562_Human2.04285829
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03980009
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.03538074
39RARB_27405468_Chip-Seq_BRAIN_Mouse2.01564811
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99633261
41MYB_26560356_Chip-Seq_TH2_Human1.99423522
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98393246
43MAF_26560356_Chip-Seq_TH2_Human1.97856401
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96925879
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95340499
46MYB_26560356_Chip-Seq_TH1_Human1.90401431
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89556849
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88881517
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83632726
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82733328
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80006396
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79311288
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.79226585
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.78036926
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77630279
56RUNX_20019798_ChIP-Seq_JUKART_Human1.74561836
57TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.69341194
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.68921240
59REST_21632747_ChIP-Seq_MESCs_Mouse1.68667689
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65899073
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65514262
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65137216
63NCOR1_26117541_ChIP-Seq_K562_Human1.64464590
64GATA1_19941826_ChIP-Seq_K562_Human1.61093789
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.60634615
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.60616795
67KDM2B_26808549_Chip-Seq_K562_Human1.59444836
68E2F1_17053090_ChIP-ChIP_MCF-7_Human1.58767122
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57926269
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.57811030
71* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57500333
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57370654
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56833530
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56483206
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55301308
76RACK7_27058665_Chip-Seq_MCF-7_Human1.53469879
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53403508
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53263314
79PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.52902022
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.52240956
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51961022
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51894381
83IRF1_19129219_ChIP-ChIP_H3396_Human1.50701037
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.49081661
85P68_20966046_ChIP-Seq_HELA_Human1.48278898
86* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47353875
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47183304
88* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46914087
89* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46914087
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.46744808
91RNF2_27304074_Chip-Seq_NSC_Mouse1.45818212
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44178013
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.43980738
94BCL6_27268052_Chip-Seq_Bcells_Human1.43223765
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42664094
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.42398749
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41930951
98BCOR_27268052_Chip-Seq_Bcells_Human1.41599408
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41423313
100SMC4_20622854_ChIP-Seq_HELA_Human1.38570122
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38167067
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.38026259
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35041072
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34790633
105* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34491458
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34265877
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.34231539
108GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31514246
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30471133
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29255846
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29159232
112GATA3_27048872_Chip-Seq_THYMUS_Human1.29116390
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28422100
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27411474
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.27399707
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26819239
117NANOG_18692474_ChIP-Seq_MESCs_Mouse1.25922728
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25780579
119NANOG_16518401_ChIP-PET_MESCs_Mouse1.22637142
120* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22216857
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22098521
122CIITA_25753668_ChIP-Seq_RAJI_Human1.21631928
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21409626
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21301940
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.21039026
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20188658
127POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.19751385
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17759212
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15881136
130TET1_21451524_ChIP-Seq_MESCs_Mouse1.14823699
131POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11670268
132RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10312447
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10280542
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09920836
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09516101
136MYC_22102868_ChIP-Seq_BL_Human1.06611369
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06281484
138GATA2_19941826_ChIP-Seq_K562_Human1.05795113
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04685138
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04564868
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04464962
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03804004
143SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03611302
144GATA1_26923725_Chip-Seq_HPCs_Mouse1.02752515
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02573431
146* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02435629
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02218876
148* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02090681
149BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01920492
150TCF7_22412390_ChIP-Seq_EML_Mouse1.01782748
151CREB1_26743006_Chip-Seq_LNCaP_Human1.01340125
152* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01200720
153* STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00180630
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.99798222
155P300_27268052_Chip-Seq_Bcells_Human0.98662985
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98642680
157PHF8_20622854_ChIP-Seq_HELA_Human0.98558695
158CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98512158
159TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98208415
160ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98182794
161* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97701462
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97410740
163EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97377754
164TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96878673
165RING1B_27294783_Chip-Seq_ESCs_Mouse0.96053460
166CTCF_26484167_Chip-Seq_Bcells_Mouse0.95094936
167* LXR_22292898_ChIP-Seq_THP-1_Human0.95024875
168ETS1_21867929_ChIP-Seq_TH2_Mouse0.94993803
169DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94828481
170* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94431918
171* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92715244
172TP53_22127205_ChIP-Seq_IMR90_Human0.92345923
173SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91880314
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91237386
175* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89822414
176EZH2_27304074_Chip-Seq_ESCs_Mouse0.88804042
177* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86330706
178SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86077721
179CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85537855
180DPY_21335234_ChIP-Seq_ESCs_Mouse0.84801678
181SOX3_22085726_ChIP-Seq_NPCs_Mouse0.83728356
182OCT4_19829295_ChIP-Seq_ESCs_Human0.83347193
183STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83057486
184AHR_22903824_ChIP-Seq_MCF-7_Human0.81509332
185NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81194320
186SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.81171493
187OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80402330
188STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80091953
189EZH2_27294783_Chip-Seq_ESCs_Mouse0.78574029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005499_abnormal_olfactory_system4.38758374
2MP0005394_taste/olfaction_phenotype4.38758374
3MP0004858_abnormal_nervous_system4.30824269
4MP0006292_abnormal_olfactory_placode3.88973550
5MP0003436_decreased_susceptibility_to3.83884303
6MP0004859_abnormal_synaptic_plasticity3.72057075
7MP0002254_reproductive_system_inflammat3.61542605
8MP0004264_abnormal_extraembryonic_tissu3.53641881
9MP0003303_peritoneal_inflammation3.44916027
10MP0001835_abnormal_antigen_presentation3.33654291
11MP0003011_delayed_dark_adaptation3.26326071
12MP0003122_maternal_imprinting3.17844135
13MP0003724_increased_susceptibility_to3.02122923
14MP0003763_abnormal_thymus_physiology2.94144368
15MP0003890_abnormal_embryonic-extraembry2.86526600
16MP0002132_abnormal_respiratory_system2.74948132
17MP0004270_analgesia2.68922570
18MP0001800_abnormal_humoral_immune2.66417729
19MP0002396_abnormal_hematopoietic_system2.58047480
20MP0002419_abnormal_innate_immunity2.56892450
21MP0005025_abnormal_response_to2.56573473
22MP0005075_abnormal_melanosome_morpholog2.46732046
23MP0005464_abnormal_platelet_physiology2.42352001
24MP0002420_abnormal_adaptive_immunity2.36094667
25MP0001819_abnormal_immune_cell2.33244216
26MP0005000_abnormal_immune_tolerance2.31882741
27MP0001790_abnormal_immune_system2.31640077
28MP0005387_immune_system_phenotype2.31640077
29MP0010155_abnormal_intestine_physiology2.29888477
30MP0002723_abnormal_immune_serum2.28117623
31MP0002332_abnormal_exercise_endurance2.25078776
32MP0003635_abnormal_synaptic_transmissio2.22418851
33MP0002452_abnormal_antigen_presenting2.20157722
34MP0002653_abnormal_ependyma_morphology2.19621703
35MP0008961_abnormal_basal_metabolism2.19502369
36MP0003121_genomic_imprinting2.19011465
37MP0003183_abnormal_peptide_metabolism2.15827692
38MP0003172_abnormal_lysosome_physiology2.14384080
39MP0002398_abnormal_bone_marrow2.13735123
40MP0003866_abnormal_defecation2.12920778
41MP0009333_abnormal_splenocyte_physiolog2.10276312
42MP0000465_gastrointestinal_hemorrhage2.08667269
43MP0003300_gastrointestinal_ulcer2.07886514
44MP0008260_abnormal_autophagy2.07661002
45MP0008789_abnormal_olfactory_epithelium2.06472052
46MP0000685_abnormal_immune_system2.04572489
47MP0006035_abnormal_mitochondrial_morpho1.99312207
48MP0009278_abnormal_bone_marrow1.97263905
49MP0005058_abnormal_lysosome_morphology1.95439119
50MP0003880_abnormal_central_pattern1.95241885
51MP0003787_abnormal_imprinting1.95013124
52MP0005671_abnormal_response_to1.94473280
53MP0002063_abnormal_learning/memory/cond1.93649206
54MP0005451_abnormal_body_composition1.87738683
55MP0002572_abnormal_emotion/affect_behav1.87727856
56MP0000716_abnormal_immune_system1.87031643
57MP0002405_respiratory_system_inflammati1.84521411
58MP0005397_hematopoietic_system_phenotyp1.80562678
59MP0001545_abnormal_hematopoietic_system1.80562678
60MP0001984_abnormal_olfaction1.80407209
61MP0009046_muscle_twitch1.80194891
62MP0001486_abnormal_startle_reflex1.79988751
63MP0002722_abnormal_immune_system1.79261592
64MP0000703_abnormal_thymus_morphology1.78501967
65MP0009785_altered_susceptibility_to1.78008741
66MP0004947_skin_inflammation1.77345021
67MP0008057_abnormal_DNA_replication1.73132476
68MP0003938_abnormal_ear_development1.72536155
69MP0003191_abnormal_cellular_cholesterol1.72323189
70MP0002064_seizures1.67386255
71MP0000689_abnormal_spleen_morphology1.67375707
72MP0002429_abnormal_blood_cell1.62221895
73MP0008004_abnormal_stomach_pH1.61106292
74MP0001533_abnormal_skeleton_physiology1.58876316
75MP0005257_abnormal_intraocular_pressure1.58466863
76MP0002148_abnormal_hypersensitivity_rea1.57573411
77MP0009745_abnormal_behavioral_response1.56899498
78MP0002009_preneoplasia1.55387157
79MP0003123_paternal_imprinting1.53061078
80MP0002734_abnormal_mechanical_nocicepti1.52705562
81MP0003656_abnormal_erythrocyte_physiolo1.51752164
82MP0001873_stomach_inflammation1.51152757
83MP0001501_abnormal_sleep_pattern1.48647331
84MP0000858_altered_metastatic_potential1.48434140
85MP0000678_abnormal_parathyroid_gland1.47902608
86MP0001845_abnormal_inflammatory_respons1.47237938
87MP0003828_pulmonary_edema1.45238546
88MP0002127_abnormal_cardiovascular_syste1.42549293
89MP0002909_abnormal_adrenal_gland1.42486641
90MP0002272_abnormal_nervous_system1.37737644
91MP0000490_abnormal_crypts_of1.37491942
92MP0004043_abnormal_pH_regulation1.37323355
93MP0004808_abnormal_hematopoietic_stem1.30549276
94MP0003705_abnormal_hypodermis_morpholog1.28169692
95MP0002184_abnormal_innervation1.26446982
96MP0004957_abnormal_blastocyst_morpholog1.25657799
97MP0008872_abnormal_physiological_respon1.24132563
98MP0008469_abnormal_protein_level1.22716279
99MP0003283_abnormal_digestive_organ1.22294231
100MP0001851_eye_inflammation1.19729960
101MP0002233_abnormal_nose_morphology1.14097223
102MP0002166_altered_tumor_susceptibility1.13904159
103MP0005076_abnormal_cell_differentiation1.13285978
104MP0002277_abnormal_respiratory_mucosa1.12738069
105MP0004381_abnormal_hair_follicle1.11870518
106MP0001663_abnormal_digestive_system1.11785510
107MP0000955_abnormal_spinal_cord1.11470332
108MP0003137_abnormal_impulse_conducting1.09834281
109MP0002733_abnormal_thermal_nociception1.08846974
110MP0001293_anophthalmia1.04811189
111MP0000762_abnormal_tongue_morphology1.04196768
112MP0001672_abnormal_embryogenesis/_devel1.03255315
113MP0005380_embryogenesis_phenotype1.03255315
114MP0002998_abnormal_bone_remodeling1.00747868
115MP0010352_gastrointestinal_tract_polyps1.00322507
116MP0002933_joint_inflammation0.99734201
117MP0002932_abnormal_joint_morphology0.98922130
118MP0002822_catalepsy0.97670452
119MP0001970_abnormal_pain_threshold0.96490676
120MP0001853_heart_inflammation0.96264531
121MP0008770_decreased_survivor_rate0.95930773
122MP0001348_abnormal_lacrimal_gland0.94902801
123MP0004185_abnormal_adipocyte_glucose0.94853200
124MP0002088_abnormal_embryonic_growth/wei0.94399572
125MP0001849_ear_inflammation0.93990553
126MP0003984_embryonic_growth_retardation0.93759725
127MP0005360_urolithiasis0.93012204
128MP0001968_abnormal_touch/_nociception0.92890554
129MP0005266_abnormal_metabolism0.91531428
130MP0005166_decreased_susceptibility_to0.91360460
131MP0000778_abnormal_nervous_system0.91224350
132MP0004811_abnormal_neuron_physiology0.89876689
133MP0002882_abnormal_neuron_morphology0.89847039
134MP0002557_abnormal_social/conspecific_i0.87560597
135MP0001440_abnormal_grooming_behavior0.87466749
136MP0002751_abnormal_autonomic_nervous0.87009935
137MP0002067_abnormal_sensory_capabilities0.86832329
138MP0004883_abnormal_blood_vessel0.86556238
139MP0003119_abnormal_digestive_system0.86552081
140MP0002752_abnormal_somatic_nervous0.86086226
141MP0006082_CNS_inflammation0.85419534
142MP0002114_abnormal_axial_skeleton0.84094355
143MP0000015_abnormal_ear_pigmentation0.83964421
144MP0002092_abnormal_eye_morphology0.83134704
145MP0010234_abnormal_vibrissa_follicle0.82869279
146MP0000049_abnormal_middle_ear0.82472052
147MP0003091_abnormal_cell_migration0.82383552
148MP0008874_decreased_physiological_sensi0.81872842
149MP0005083_abnormal_biliary_tract0.79771932
150MP0001765_abnormal_ion_homeostasis0.79415131
151MP0000249_abnormal_blood_vessel0.79410880
152MP0003861_abnormal_nervous_system0.78561826
153MP0004142_abnormal_muscle_tone0.77261994
154MP0005623_abnormal_meninges_morphology0.76531516
155MP0000681_abnormal_thyroid_gland0.76197526
156MP0005666_abnormal_adipose_tissue0.74974968
157MP0002019_abnormal_tumor_incidence0.74759365
158MP0004085_abnormal_heartbeat0.73770038
159MP0005390_skeleton_phenotype0.73696737
160MP0005409_darkened_coat_color0.73198325
161MP0004133_heterotaxia0.72742359
162MP0009763_increased_sensitivity_to0.71840409
163MP0005381_digestive/alimentary_phenotyp0.70215927
164MP0003045_fibrosis0.69775947
165MP0000477_abnormal_intestine_morphology0.68905882
166MP0002081_perinatal_lethality0.68276541
167MP0005164_abnormal_response_to0.67867648
168MP0000631_abnormal_neuroendocrine_gland0.67536285
169MP0000350_abnormal_cell_proliferation0.67294501
170MP0001986_abnormal_taste_sensitivity0.67260397
171MP0002970_abnormal_white_adipose0.67258410
172MP0002152_abnormal_brain_morphology0.65756779
173MP0009840_abnormal_foam_cell0.65659620
174MP0005391_vision/eye_phenotype0.65598496
175MP0002086_abnormal_extraembryonic_tissu0.65269158
176MP0002249_abnormal_larynx_morphology0.64947525
177MP0002085_abnormal_embryonic_tissue0.64714792
178MP0003453_abnormal_keratinocyte_physiol0.63525833
179MP0003935_abnormal_craniofacial_develop0.63410794
180MP0005310_abnormal_salivary_gland0.62222612
181MP0002229_neurodegeneration0.62034411
182MP0003755_abnormal_palate_morphology0.60953908
183MP0001664_abnormal_digestion0.60346094
184MP0005621_abnormal_cell_physiology0.60023418
185MP0002066_abnormal_motor_capabilities/c0.59705637
186MP0003448_altered_tumor_morphology0.59182646
187MP0005253_abnormal_eye_physiology0.59163389
188MP0003795_abnormal_bone_structure0.57724914
189MP0005410_abnormal_fertilization0.57476633
190MP0009764_decreased_sensitivity_to0.57399930
191MP0000470_abnormal_stomach_morphology0.56111686

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.11466658
2Hypochromic microcytic anemia (HP:0004840)6.37123699
3Abnormality of the lower motor neuron (HP:0002366)5.68251191
4Eczematoid dermatitis (HP:0000976)5.33000524
5Hepatoblastoma (HP:0002884)5.24811072
6Recurrent abscess formation (HP:0002722)4.87383517
7Recurrent bacterial skin infections (HP:0005406)4.80381757
8Nasal polyposis (HP:0100582)4.46560462
9Hyperventilation (HP:0002883)4.35208500
10Multiple enchondromatosis (HP:0005701)4.14808250
11Rib fusion (HP:0000902)4.12331741
12Myositis (HP:0100614)3.98538574
13Elevated erythrocyte sedimentation rate (HP:0003565)3.97982953
14Abnormality of macrophages (HP:0004311)3.87235691
15Abnormality of the nasal mucosa (HP:0000433)3.86339351
16Gastrointestinal infarctions (HP:0005244)3.74445341
17Chronic obstructive pulmonary disease (HP:0006510)3.70277362
18Obstructive lung disease (HP:0006536)3.70277362
19Prolonged bleeding time (HP:0003010)3.69691769
20Febrile seizures (HP:0002373)3.64575784
21Ependymoma (HP:0002888)3.59696787
22Testicular atrophy (HP:0000029)3.59113814
23Amyotrophic lateral sclerosis (HP:0007354)3.57144077
24Amblyopia (HP:0000646)3.44015341
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.43808165
26Recurrent gram-negative bacterial infections (HP:0005420)3.40248252
27Neoplasm of striated muscle (HP:0009728)3.37952516
28Recurrent fungal infections (HP:0002841)3.35676062
29Meningitis (HP:0001287)3.31127062
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.29496575
31Epileptic encephalopathy (HP:0200134)3.24232251
32Bifid tongue (HP:0010297)3.23071285
33Increased IgE level (HP:0003212)3.20606095
34Horizontal nystagmus (HP:0000666)3.20404252
35Nephroblastoma (Wilms tumor) (HP:0002667)3.16899154
36Generalized hypotonia (HP:0001290)3.15139167
37Recurrent skin infections (HP:0001581)3.14895577
38Dynein arm defect of respiratory motile cilia (HP:0012255)3.11532061
39Absent/shortened dynein arms (HP:0200106)3.11532061
40Cellulitis (HP:0100658)3.11070274
41Pustule (HP:0200039)3.10705850
42Stomatitis (HP:0010280)3.06402047
43Gastrointestinal inflammation (HP:0004386)3.05628570
44Spontaneous hematomas (HP:0007420)3.05191190
45Petechiae (HP:0000967)3.03138482
46Recurrent viral infections (HP:0004429)3.00838165
47Panhypogammaglobulinemia (HP:0003139)2.98418325
48Ragged-red muscle fibers (HP:0003200)2.98337573
49Rhabdomyosarcoma (HP:0002859)2.98013642
50Inflammation of the large intestine (HP:0002037)2.95252354
51Embryonal renal neoplasm (HP:0011794)2.93539731
52Focal seizures (HP:0007359)2.92734559
53Atonic seizures (HP:0010819)2.91392855
54Colitis (HP:0002583)2.84529669
55Abnormal respiratory epithelium morphology (HP:0012253)2.83379953
56Abnormal respiratory motile cilium morphology (HP:0005938)2.83379953
57Orchitis (HP:0100796)2.82453523
58Mediastinal lymphadenopathy (HP:0100721)2.81047657
59Gingivitis (HP:0000230)2.80874846
60Recurrent cutaneous fungal infections (HP:0011370)2.80531471
61Chronic mucocutaneous candidiasis (HP:0002728)2.80531471
62Agammaglobulinemia (HP:0004432)2.79973875
63Abnormality of the astrocytes (HP:0100707)2.79906912
64Astrocytoma (HP:0009592)2.79906912
65Abnormality of the fingertips (HP:0001211)2.79273764
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.77945826
67Hypoplasia of the fovea (HP:0007750)2.77945826
68Epistaxis (HP:0000421)2.77145821
69Encephalitis (HP:0002383)2.74915887
70Resting tremor (HP:0002322)2.74697417
71Abnormal respiratory motile cilium physiology (HP:0012261)2.73615788
72Neoplasm of the heart (HP:0100544)2.69113922
73Chronic otitis media (HP:0000389)2.68478651
74Sensory axonal neuropathy (HP:0003390)2.67190962
75Purpura (HP:0000979)2.66756316
76Recurrent sinusitis (HP:0011108)2.65136658
77Chest pain (HP:0100749)2.64997953
78Dialeptic seizures (HP:0011146)2.62933866
79Vasculitis (HP:0002633)2.61921310
80Abnormal ciliary motility (HP:0012262)2.61724001
81Rectal fistula (HP:0100590)2.59754281
82Rectovaginal fistula (HP:0000143)2.59754281
83Tetraplegia (HP:0002445)2.56716558
84Partial duplication of thumb phalanx (HP:0009944)2.55451305
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51707053
86Anomalous pulmonary venous return (HP:0010772)2.50311339
87Retrobulbar optic neuritis (HP:0100654)2.48929016
88Optic neuritis (HP:0100653)2.48929016
89Abnormality of the salivary glands (HP:0010286)2.48709865
90Dyschromatopsia (HP:0007641)2.48693458
91Bronchiectasis (HP:0002110)2.48570878
92Focal motor seizures (HP:0011153)2.48339353
93Osteomyelitis (HP:0002754)2.48202737
94Abnormality of T cell physiology (HP:0011840)2.46645490
95Granulocytopenia (HP:0001913)2.44721156
96Preauricular pit (HP:0004467)2.43161081
97Periauricular skin pits (HP:0100277)2.43161081
98Hemiparesis (HP:0001269)2.41774597
99Intestinal fistula (HP:0100819)2.41294464
100Abnormality of T cells (HP:0002843)2.37038022
101Hypochromic anemia (HP:0001931)2.36883382
102Amyloidosis (HP:0011034)2.36369694
103Fused cervical vertebrae (HP:0002949)2.35544673
104Hyperinsulinemic hypoglycemia (HP:0000825)2.33601819
105Urticaria (HP:0001025)2.33247709
106Rhinitis (HP:0012384)2.31022620
107Polygenic inheritance (HP:0010982)2.30014469
108Preauricular skin tag (HP:0000384)2.29423758
109Recurrent otitis media (HP:0000403)2.28745113
110Hypertensive crisis (HP:0100735)2.28745011
111Polycythemia (HP:0001901)2.27504143
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.27194847
113Abnormality of chromosome segregation (HP:0002916)2.27027401
114Vaginal fistula (HP:0004320)2.25428493
115Malnutrition (HP:0004395)2.24923078
116Short humerus (HP:0005792)2.22323274
117Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21815269
118Malignant neoplasm of the central nervous system (HP:0100836)2.21600586
119Renal duplication (HP:0000075)2.21416264
120Hemorrhage of the eye (HP:0011885)2.20924917
121Gingival bleeding (HP:0000225)2.20552511
122Myokymia (HP:0002411)2.20077950
123Abnormality of the fovea (HP:0000493)2.19587405
124Seborrheic dermatitis (HP:0001051)2.15827552
125Recurrent bronchitis (HP:0002837)2.15557854
126Aplasia/hypoplasia of the humerus (HP:0006507)2.15545552
127Partial duplication of the phalanx of hand (HP:0009999)2.14645335
128Increased serum ferritin (HP:0003281)2.14364431
129Viral hepatitis (HP:0006562)2.12861455
130Generalized tonic-clonic seizures (HP:0002069)2.12639399
131Thrombocytosis (HP:0001894)2.12153728
132Status epilepticus (HP:0002133)2.12018641
133Papilloma (HP:0012740)2.11676834
134Verrucae (HP:0200043)2.11676834
135Nasolacrimal duct obstruction (HP:0000579)2.11061458
136Abnormality of the pubic bones (HP:0003172)2.10347480
137Atelectasis (HP:0100750)2.09864029
138Skin tags (HP:0010609)2.08364239
139Abnormal platelet function (HP:0011869)2.08360940
140Impaired platelet aggregation (HP:0003540)2.08360940
141Abnormal lung lobation (HP:0002101)2.08316199
142Lymphopenia (HP:0001888)2.05962822
143Abnormality of the pulmonary veins (HP:0011718)2.04722137
144Abnormality of the phalanges of the hallux (HP:0010057)2.04180585
145Trismus (HP:0000211)2.03491416
146Episodic fever (HP:0001954)2.02425046
147Arterial thrombosis (HP:0004420)2.02371754
148Abnormality of small intestinal villus morphology (HP:0011472)2.02147366
149Villous atrophy (HP:0011473)2.02147366
150Absence seizures (HP:0002121)2.01912073
151Large earlobe (HP:0009748)2.01892511
152T lymphocytopenia (HP:0005403)2.01572016
153Difficulty running (HP:0009046)2.01369064
154Bronchitis (HP:0012387)2.00485633
155Shawl scrotum (HP:0000049)1.99433762
156Abnormality of cells of the lymphoid lineage (HP:0012140)1.98253560
157Hand muscle atrophy (HP:0009130)1.98144922
158Abnormal cartilage morphology (HP:0002763)1.97430069
159Progressive external ophthalmoplegia (HP:0000590)1.97137196
160Glioma (HP:0009733)1.95710461
161Hypopigmentation of the fundus (HP:0007894)1.95679541
162Visual hallucinations (HP:0002367)1.94937321
163Slow saccadic eye movements (HP:0000514)1.93999857
164Hemoptysis (HP:0002105)1.93973047
165Sepsis (HP:0100806)1.93722141
166Abnormality of the corticospinal tract (HP:0002492)1.92686438
167Supernumerary spleens (HP:0009799)1.92667467
168Achilles tendon contracture (HP:0001771)1.91999920
169Chronic sinusitis (HP:0011109)1.91900742
170Abnormality of the musculature of the hand (HP:0001421)1.91457314
171Centrally nucleated skeletal muscle fibers (HP:0003687)1.91099940
172Pendular nystagmus (HP:0012043)1.90916097
173Abnormality of T cell number (HP:0011839)1.90883367
174Supernumerary nipples (HP:0002558)1.90689238
175Spastic tetraparesis (HP:0001285)1.90606065
176Skin pits (HP:0100276)1.90404600
177Abnormality of iron homeostasis (HP:0011031)1.90270995
178Metaphyseal cupping (HP:0003021)1.89827853
179Leukocytosis (HP:0001974)1.88477560
180Progressive muscle weakness (HP:0003323)1.88030039
181Abnormality of the heme biosynthetic pathway (HP:0010472)1.87253174
182Neuroectodermal neoplasm (HP:0030061)1.87108531
183Neuroepithelial neoplasm (HP:0030063)1.87108531
184Nervous tissue neoplasm (HP:0030060)1.87108531
185Facial cleft (HP:0002006)1.86806541
186Fatigue (HP:0012378)1.85494905
187Multifactorial inheritance (HP:0001426)1.85253054
188Open mouth (HP:0000194)1.85043658
189Gastrointestinal stroma tumor (HP:0100723)1.84262457
190Skin ulcer (HP:0200042)1.83228619
191Dysphonia (HP:0001618)1.82662834
192Atrophy/Degeneration involving motor neurons (HP:0007373)1.82533140
193Hypergammaglobulinemia (HP:0010702)1.82198932
194Pulmonary infiltrates (HP:0002113)1.81649628
195Tongue fasciculations (HP:0001308)1.81265189
196Tented upper lip vermilion (HP:0010804)1.81165207
197Drooling (HP:0002307)1.79710128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.45063640
2GRK55.41837347
3GRK64.16505511
4MAP4K13.86018962
5ERN13.61147701
6TYRO32.94110020
7GRK12.93540420
8TRIB32.93085052
9MAP3K92.75469916
10ADRBK22.65143390
11MAP2K32.45731613
12TYK22.44867809
13CSF1R2.37953618
14FES2.34510435
15EPHA42.30222095
16NTRK12.16031495
17MAPK72.15086170
18MATK2.14092981
19ZAP702.07472449
20SMG12.07427053
21MAP2K42.05894022
22BTK2.01580833
23GRK71.99808853
24BLK1.99418014
25NTRK31.94835308
26MOS1.93593903
27MAPK151.93500815
28WNK11.91298746
29DAPK21.66499831
30IRAK41.65659374
31TGFBR21.61957896
32ARAF1.58249623
33SIK31.56796998
34TTK1.48233518
35CAMK41.47427036
36HCK1.45646805
37TBK11.43904379
38MAP3K141.35704326
39MARK21.35098048
40EPHB11.35040434
41SIK21.30815635
42SYK1.29795360
43JAK31.28242244
44PRPF4B1.27651893
45MAP3K31.24589752
46MAP3K11.24200590
47EEF2K1.22227093
48MAP3K111.21641302
49TXK1.16686875
50NME21.16079451
51ITK1.14946898
52STK101.13332398
53LRRK21.10584452
54TEC1.10569937
55PTK61.10128678
56MAP3K41.07045220
57HIPK21.06985589
58MAP3K71.06205881
59DAPK11.02493597
60AKT31.01507247
61LYN1.00963283
62LCK0.99834002
63NTRK20.95036742
64JAK20.94754366
65CASK0.94407596
66KIT0.93929701
67PDPK10.93565907
68PAK60.92296519
69IKBKE0.92008975
70PKN20.91937826
71MAP3K130.90883761
72PRKG20.90759566
73TAOK20.90659886
74MAP3K20.89603678
75ADRBK10.89234798
76JAK10.88566537
77BMPR20.86510549
78RIPK10.85124252
79MST1R0.84809896
80KSR20.84478895
81STK380.84104317
82TESK20.83739212
83ALK0.83408947
84RIPK40.82804109
85MAPK120.82707037
86MARK30.82404080
87PRKD30.81983355
88PRKCG0.81576320
89FGFR30.80856700
90CDK40.79284549
91MAP3K100.76013724
92MINK10.75502376
93MAP2K60.73204272
94SIK10.72468062
95MAPK110.71721070
96MAP3K60.69247350
97RET0.67430547
98CDK60.64361640
99CDK50.62906849
100TAOK30.62600803
101YES10.62055069
102FGFR40.59748014
103MAP3K80.59433611
104PRKCH0.59227153
105MAP2K20.58129630
106CHEK20.58120194
107DYRK1A0.57924815
108MAP2K70.57717754
109PRKCQ0.55077432
110RPS6KA40.54624768
111TRPM70.54095253
112CDK150.53728435
113KDR0.53194219
114PASK0.52488329
115AKT20.52303701
116BRD40.52004615
117CDK180.51852958
118TNK20.50800056
119CDK70.50523565
120PRKD20.49855733
121CSK0.49343717
122IKBKB0.48991718
123PDGFRA0.48461917
124PAK30.47429492
125FYN0.46757209
126RPS6KC10.46231890
127RPS6KL10.46231890
128CDK11A0.45213677
129PTK2B0.44290858
130DYRK1B0.43747605
131TAOK10.43649531
132MAPK100.42566223
133KSR10.42108146
134PAK40.41765613
135PLK10.41353835
136CDK140.40265627
137CAMK10.40080215
138PDK10.39500368
139CAMKK10.38936228
140PRKCI0.37828951
141EPHA20.37451606
142LATS20.37385378
143MAPKAPK20.36703608
144CHEK10.36315890
145RAF10.35710340
146PIM10.35673236
147UHMK10.35130081
148CDK190.34662012
149ICK0.34090913
150PLK20.32181201
151FGR0.31554678
152DDR20.30190139
153CSNK1E0.28104204
154BMX0.27032394
155PTK20.26867575
156MARK10.26634286
157RPS6KA30.26143067
158PHKG10.23303266
159PHKG20.23303266
160PRKCD0.22649838
161GSK3B0.22271883
162STK110.22094061
163CDC42BPA0.21795843
164CDK20.21318408
165BRAF0.21005811
166IGF1R0.20289231
167PRKACA0.18983992

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.50119622
2Vitamin B6 metabolism_Homo sapiens_hsa007503.60763676
3Olfactory transduction_Homo sapiens_hsa047402.95403468
4Other glycan degradation_Homo sapiens_hsa005112.75845262
5Glutamatergic synapse_Homo sapiens_hsa047242.45905703
6Leishmaniasis_Homo sapiens_hsa051402.45686449
7Osteoclast differentiation_Homo sapiens_hsa043802.39253129
8Long-term potentiation_Homo sapiens_hsa047202.36540145
9Acute myeloid leukemia_Homo sapiens_hsa052212.32154645
10GABAergic synapse_Homo sapiens_hsa047272.28722816
11Nicotine addiction_Homo sapiens_hsa050332.26274341
12Fructose and mannose metabolism_Homo sapiens_hsa000512.21885437
13Primary immunodeficiency_Homo sapiens_hsa053402.17339741
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14915602
15Synaptic vesicle cycle_Homo sapiens_hsa047212.13828418
16Allograft rejection_Homo sapiens_hsa053302.05063491
17Graft-versus-host disease_Homo sapiens_hsa053322.02868208
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01581114
19Autoimmune thyroid disease_Homo sapiens_hsa053201.97725843
20Taste transduction_Homo sapiens_hsa047421.96241248
21Circadian entrainment_Homo sapiens_hsa047131.95281691
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81389031
23Staphylococcus aureus infection_Homo sapiens_hsa051501.77181322
24Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.74161501
25Serotonergic synapse_Homo sapiens_hsa047261.73418689
26Dopaminergic synapse_Homo sapiens_hsa047281.70702402
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68558919
28Amphetamine addiction_Homo sapiens_hsa050311.66637405
29Morphine addiction_Homo sapiens_hsa050321.66185810
30Salivary secretion_Homo sapiens_hsa049701.63191709
31Chronic myeloid leukemia_Homo sapiens_hsa052201.58492037
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56947374
33mTOR signaling pathway_Homo sapiens_hsa041501.54761377
34Viral myocarditis_Homo sapiens_hsa054161.53685958
35Tuberculosis_Homo sapiens_hsa051521.53095383
36GnRH signaling pathway_Homo sapiens_hsa049121.52975487
37Long-term depression_Homo sapiens_hsa047301.52693882
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51353744
39Hematopoietic cell lineage_Homo sapiens_hsa046401.50658346
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46624318
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44917264
42Antigen processing and presentation_Homo sapiens_hsa046121.43973618
43Pancreatic cancer_Homo sapiens_hsa052121.43789910
44Calcium signaling pathway_Homo sapiens_hsa040201.42161944
45Measles_Homo sapiens_hsa051621.41181794
46Herpes simplex infection_Homo sapiens_hsa051681.40859770
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40339016
48Oxytocin signaling pathway_Homo sapiens_hsa049211.38940796
49Influenza A_Homo sapiens_hsa051641.38464499
50Toxoplasmosis_Homo sapiens_hsa051451.37015928
51Galactose metabolism_Homo sapiens_hsa000521.32765177
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.32152332
53Asthma_Homo sapiens_hsa053101.31817120
54Type I diabetes mellitus_Homo sapiens_hsa049401.31036662
55Platelet activation_Homo sapiens_hsa046111.29490113
56Insulin secretion_Homo sapiens_hsa049111.29198092
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27448459
58Chemokine signaling pathway_Homo sapiens_hsa040621.26035074
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25398315
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.24694019
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23920455
62Hepatitis B_Homo sapiens_hsa051611.23124006
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.21055788
64Renin secretion_Homo sapiens_hsa049241.19949979
65cAMP signaling pathway_Homo sapiens_hsa040241.16928062
66Inositol phosphate metabolism_Homo sapiens_hsa005621.16530945
67Cholinergic synapse_Homo sapiens_hsa047251.15082884
68Arachidonic acid metabolism_Homo sapiens_hsa005901.13129219
69Notch signaling pathway_Homo sapiens_hsa043301.12265482
70Jak-STAT signaling pathway_Homo sapiens_hsa046301.11573661
71Choline metabolism in cancer_Homo sapiens_hsa052311.09608235
72Gastric acid secretion_Homo sapiens_hsa049711.09498323
73Malaria_Homo sapiens_hsa051441.09125424
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08660571
75VEGF signaling pathway_Homo sapiens_hsa043701.06394037
76TNF signaling pathway_Homo sapiens_hsa046681.06276200
77Apoptosis_Homo sapiens_hsa042101.05395806
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04214077
79Hepatitis C_Homo sapiens_hsa051601.03428650
80Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02295897
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00135394
82Linoleic acid metabolism_Homo sapiens_hsa005910.99150892
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98117131
84Renal cell carcinoma_Homo sapiens_hsa052110.97835047
85Ovarian steroidogenesis_Homo sapiens_hsa049130.97797408
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.96205730
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94639070
88Thyroid cancer_Homo sapiens_hsa052160.94153469
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93045207
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91550594
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91491538
92Rap1 signaling pathway_Homo sapiens_hsa040150.89127898
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.87082989
94Shigellosis_Homo sapiens_hsa051310.83796243
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83465832
96Non-small cell lung cancer_Homo sapiens_hsa052230.82902191
97ErbB signaling pathway_Homo sapiens_hsa040120.81246109
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81059332
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80937305
100Glioma_Homo sapiens_hsa052140.80704608
101Ras signaling pathway_Homo sapiens_hsa040140.80276098
102Endocytosis_Homo sapiens_hsa041440.79114242
103Gap junction_Homo sapiens_hsa045400.78894183
104HTLV-I infection_Homo sapiens_hsa051660.76593321
105B cell receptor signaling pathway_Homo sapiens_hsa046620.76056223
106Viral carcinogenesis_Homo sapiens_hsa052030.75505095
107Collecting duct acid secretion_Homo sapiens_hsa049660.75447862
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75096555
109Dorso-ventral axis formation_Homo sapiens_hsa043200.74865785
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74731958
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74390492
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74024893
113Phagosome_Homo sapiens_hsa041450.72805882
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.71988439
115African trypanosomiasis_Homo sapiens_hsa051430.71806152
116Epstein-Barr virus infection_Homo sapiens_hsa051690.70078363
117Oocyte meiosis_Homo sapiens_hsa041140.69892215
118Axon guidance_Homo sapiens_hsa043600.68160148
119MAPK signaling pathway_Homo sapiens_hsa040100.68027578
120Pertussis_Homo sapiens_hsa051330.67540503
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66381542
122Melanogenesis_Homo sapiens_hsa049160.64743736
123Prolactin signaling pathway_Homo sapiens_hsa049170.63071954
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.62860085
125Legionellosis_Homo sapiens_hsa051340.60265777
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59899584
127Insulin resistance_Homo sapiens_hsa049310.59707373
128FoxO signaling pathway_Homo sapiens_hsa040680.59573068
129Cocaine addiction_Homo sapiens_hsa050300.58938393
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58763104
131Wnt signaling pathway_Homo sapiens_hsa043100.58539529
132Estrogen signaling pathway_Homo sapiens_hsa049150.57414698
133mRNA surveillance pathway_Homo sapiens_hsa030150.57116333
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.57115476
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.56680346
136Salmonella infection_Homo sapiens_hsa051320.56171757
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55748590
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55524600
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.54910627
140Amoebiasis_Homo sapiens_hsa051460.53799521
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.53243449
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50848175
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50592784
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50058054
145Dilated cardiomyopathy_Homo sapiens_hsa054140.48403752
146Phototransduction_Homo sapiens_hsa047440.48173791
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47258642
148Lysosome_Homo sapiens_hsa041420.46459428
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46061629
150Ether lipid metabolism_Homo sapiens_hsa005650.45584383
151Insulin signaling pathway_Homo sapiens_hsa049100.45545322
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45172545
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43938439
154Pentose phosphate pathway_Homo sapiens_hsa000300.43673281
155Hedgehog signaling pathway_Homo sapiens_hsa043400.43397344
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43181943
157Prostate cancer_Homo sapiens_hsa052150.43065489
158Renin-angiotensin system_Homo sapiens_hsa046140.41771737
159Endometrial cancer_Homo sapiens_hsa052130.41684723
160Type II diabetes mellitus_Homo sapiens_hsa049300.40236115
161Tight junction_Homo sapiens_hsa045300.40229353
162Pathways in cancer_Homo sapiens_hsa052000.39694972
163T cell receptor signaling pathway_Homo sapiens_hsa046600.38572632
164Colorectal cancer_Homo sapiens_hsa052100.38108490
165Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37890995
166Cardiac muscle contraction_Homo sapiens_hsa042600.37850966
167AMPK signaling pathway_Homo sapiens_hsa041520.33251991
168Glucagon signaling pathway_Homo sapiens_hsa049220.32819577
169Leukocyte transendothelial migration_Homo sapiens_hsa046700.31517844

Most similar genes based on co-expression Upload to Enrichr

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