LTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to xenobiotic stimulus (GO:0009410)7.00103926
2nuclear pore complex assembly (GO:0051292)6.76899538
3cysteine metabolic process (GO:0006534)6.72649588
4response to nitrosative stress (GO:0051409)6.41621353
5mitotic sister chromatid cohesion (GO:0007064)6.18000674
6nuclear pore organization (GO:0006999)6.11065055
7definitive hemopoiesis (GO:0060216)5.06305158
8monoubiquitinated protein deubiquitination (GO:0035520)5.00782640
9heparin biosynthetic process (GO:0030210)4.85489848
10heparin metabolic process (GO:0030202)4.85489848
11regulation of RNA export from nucleus (GO:0046831)4.75138750
12pore complex assembly (GO:0046931)4.72499081
13negative regulation of T cell differentiation in thymus (GO:0033085)4.68775105
14regulation of DNA endoreduplication (GO:0032875)4.47107640
15intra-S DNA damage checkpoint (GO:0031573)4.45682200
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.41174244
17viral mRNA export from host cell nucleus (GO:0046784)4.25988298
18regulation of nucleobase-containing compound transport (GO:0032239)4.22142707
19sister chromatid segregation (GO:0000819)4.21512805
20regulation of translational fidelity (GO:0006450)4.14126859
21DNA unwinding involved in DNA replication (GO:0006268)4.08997945
22mitotic chromosome condensation (GO:0007076)4.03831479
23COPI coating of Golgi vesicle (GO:0048205)3.93899016
24Golgi transport vesicle coating (GO:0048200)3.93899016
25protein K11-linked deubiquitination (GO:0035871)3.93078624
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.90271308
27L-ascorbic acid metabolic process (GO:0019852)3.89351704
28negative regulation of DNA recombination (GO:0045910)3.80568503
29mitotic nuclear envelope disassembly (GO:0007077)3.78653494
30nuclear envelope disassembly (GO:0051081)3.77037135
31membrane disassembly (GO:0030397)3.77037135
32peptidyl-lysine dimethylation (GO:0018027)3.75664292
33double-strand break repair via nonhomologous end joining (GO:0006303)3.75403045
34non-recombinational repair (GO:0000726)3.75403045
35ribosome assembly (GO:0042255)3.73977853
36S-adenosylmethionine metabolic process (GO:0046500)3.73244101
37NLS-bearing protein import into nucleus (GO:0006607)3.70053882
38regulation of translational termination (GO:0006449)3.67902493
39regulation of histone H3-K9 methylation (GO:0051570)3.65399300
40acrosome assembly (GO:0001675)3.61978205
41protein localization to kinetochore (GO:0034501)3.54974645
42regulation of protein polyubiquitination (GO:1902914)3.52228891
43chromosome condensation (GO:0030261)3.48116308
44nucleus organization (GO:0006997)3.46440610
45pre-miRNA processing (GO:0031054)3.46007912
46centriole replication (GO:0007099)3.43338900
47mitotic sister chromatid segregation (GO:0000070)3.43153620
48spindle assembly involved in mitosis (GO:0090307)3.41728099
49negative regulation of histone methylation (GO:0031061)3.37766706
50regulation of centriole replication (GO:0046599)3.35011694
51response to pheromone (GO:0019236)3.34865959
52phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29392034
53protein targeting to Golgi (GO:0000042)3.26284197
54DNA geometric change (GO:0032392)3.23560934
55DNA duplex unwinding (GO:0032508)3.21907238
56regulation of interleukin-12 biosynthetic process (GO:0045075)3.21146732
57regulation of mitotic spindle organization (GO:0060236)3.20120080
58microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.18552672
59cytoplasmic mRNA processing body assembly (GO:0033962)3.17605364
60establishment of protein localization to Golgi (GO:0072600)3.16995322
61chromatin assembly (GO:0031497)3.15952983
62dosage compensation (GO:0007549)3.15145676
63regulation of spindle organization (GO:0090224)3.15016608
64microtubule polymerization or depolymerization (GO:0031109)3.14182391
65retrograde transport, vesicle recycling within Golgi (GO:0000301)3.13279134
66regulation of mitochondrial depolarization (GO:0051900)3.12726185
67positive regulation of histone H3-K4 methylation (GO:0051571)3.10224490
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.10095900
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10095900
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10095900
71regulation of meiosis I (GO:0060631)3.09776978
72protein localization to chromosome, centromeric region (GO:0071459)3.08542063
73positive regulation of chromosome segregation (GO:0051984)3.08191776
74gene silencing by RNA (GO:0031047)3.07946013
75regulation of centrosome duplication (GO:0010824)3.05738271
76DNA packaging (GO:0006323)3.04378571
77rRNA methylation (GO:0031167)3.03945996
78sister chromatid cohesion (GO:0007062)3.03071378
79regulation of translational elongation (GO:0006448)3.02071128
80positive regulation of histone deacetylation (GO:0031065)2.99421720
81chaperone-mediated protein complex assembly (GO:0051131)2.98993159
82histone mRNA catabolic process (GO:0071044)2.96944426
83translesion synthesis (GO:0019985)2.96554189
84sperm motility (GO:0030317)2.95731609
85musculoskeletal movement (GO:0050881)2.93842672
86multicellular organismal movement (GO:0050879)2.93842672
87protein export from nucleus (GO:0006611)2.92690997
88regulation of sister chromatid cohesion (GO:0007063)2.92246442
89zinc ion transport (GO:0006829)2.89621886
90nuclear envelope organization (GO:0006998)2.89509281
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87764646
92isotype switching (GO:0045190)2.87764646
93somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87764646
94regulation of centrosome cycle (GO:0046605)2.86618392
95ncRNA catabolic process (GO:0034661)2.86037685
96myelin assembly (GO:0032288)2.83128442
97replication fork processing (GO:0031297)2.82998303
98DNA conformation change (GO:0071103)2.81297686
99cytoskeleton-dependent cytokinesis (GO:0061640)2.80315693
100protein localization to Golgi apparatus (GO:0034067)2.79231721
101DNA replication-dependent nucleosome assembly (GO:0006335)2.78082530
102DNA replication-dependent nucleosome organization (GO:0034723)2.78082530
103regulation of gamma-delta T cell differentiation (GO:0045586)2.77664023
104gene silencing (GO:0016458)2.76059764
105mitotic cytokinesis (GO:0000281)2.75885121
106cellular response to glucose starvation (GO:0042149)2.75160387
107negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.74948697
108establishment of mitotic spindle localization (GO:0040001)2.74545265
109regulation of thymocyte apoptotic process (GO:0070243)2.72513963
110mRNA stabilization (GO:0048255)2.71021188
111RNA stabilization (GO:0043489)2.71021188
112microtubule anchoring (GO:0034453)2.69729258
113regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.69553475
114COPII vesicle coating (GO:0048208)2.69540513
115intestinal epithelial cell development (GO:0060576)2.69203139
116histone H2A monoubiquitination (GO:0035518)2.66958038
117glucocorticoid receptor signaling pathway (GO:0042921)2.64735757
118mitotic spindle organization (GO:0007052)2.64648622
119negative regulation of DNA repair (GO:0045738)2.64395332
120meiotic cell cycle (GO:0051321)2.63338189
121interkinetic nuclear migration (GO:0022027)2.62802767
122regulation of T cell differentiation in thymus (GO:0033081)2.62214432
123microtubule depolymerization (GO:0007019)2.61813063
124negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.61396700
125establishment of nucleus localization (GO:0040023)2.60844962
126establishment of mitotic spindle orientation (GO:0000132)2.60118486
127spermatid nucleus differentiation (GO:0007289)2.59317953
128protein localization to endosome (GO:0036010)2.58346662
129lipid translocation (GO:0034204)2.58181383
130phospholipid translocation (GO:0045332)2.58181383
131Golgi to endosome transport (GO:0006895)2.58002237
132histone H3-K9 methylation (GO:0051567)2.57782725
133regulation of establishment of cell polarity (GO:2000114)2.57669080
134histone phosphorylation (GO:0016572)2.57096971
135positive regulation of T cell apoptotic process (GO:0070234)2.56385727
136genitalia morphogenesis (GO:0035112)2.55634920
137inositol phosphate catabolic process (GO:0071545)2.53776620
138chromatin silencing (GO:0006342)2.53715046
139vesicle coating (GO:0006901)2.52920009
140histone-serine phosphorylation (GO:0035404)2.52809978
141attachment of spindle microtubules to kinetochore (GO:0008608)2.52618804
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.52453421
143response to arsenic-containing substance (GO:0046685)2.52333787
144positive regulation of cell cycle checkpoint (GO:1901978)2.52237155
145proteasome assembly (GO:0043248)2.51633849
146DNA topological change (GO:0006265)2.51461234
147regulation of DNA damage checkpoint (GO:2000001)2.50354529
148corticosteroid receptor signaling pathway (GO:0031958)2.49857883
149folic acid-containing compound biosynthetic process (GO:0009396)2.49179163
150regulation of mitotic sister chromatid separation (GO:0010965)2.48831121
151regulation of mitotic sister chromatid segregation (GO:0033047)2.48831121
152regulation of sister chromatid segregation (GO:0033045)2.48831121
153response to epidermal growth factor (GO:0070849)2.48524069
154negative regulation of neurotransmitter secretion (GO:0046929)2.48260792
155protein K48-linked deubiquitination (GO:0071108)2.47912530
156somatic recombination of immunoglobulin gene segments (GO:0016447)2.47522834
157peptidyl-threonine phosphorylation (GO:0018107)2.47222465
158regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.46774643
159positive regulation of T cell differentiation in thymus (GO:0033089)2.45465072
160N-terminal protein amino acid acetylation (GO:0006474)2.45365592
161prenylation (GO:0097354)2.45279132
162protein prenylation (GO:0018342)2.45279132
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.41264974
164regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.41264974
165neural tube formation (GO:0001841)2.40708722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.30807725
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.30743952
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.35430758
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.08197450
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.98310265
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.74970790
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37011300
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.73737140
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72073358
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66186414
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.61216520
12AR_21909140_ChIP-Seq_LNCAP_Human2.45886374
13GBX2_23144817_ChIP-Seq_PC3_Human2.32688603
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30199146
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.29481205
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24453930
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17377226
18IGF1R_20145208_ChIP-Seq_DFB_Human2.07136654
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02332350
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94753597
21P300_19829295_ChIP-Seq_ESCs_Human1.92283917
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.74013512
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72425612
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71314130
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67311740
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65448240
27ELK1_19687146_ChIP-ChIP_HELA_Human1.65324726
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61086452
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59547117
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58328951
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56124536
32CBP_20019798_ChIP-Seq_JUKART_Human1.56124536
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55359907
34CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54037079
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52427685
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.49478740
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46368133
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45832184
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45423935
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44439930
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43361032
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43262258
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42975854
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42151623
45ZNF274_21170338_ChIP-Seq_K562_Hela1.40385874
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40268532
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.38531971
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36873124
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36648530
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35623967
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35623967
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.34449330
53MYC_22102868_ChIP-Seq_BL_Human1.33252506
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32956739
55VDR_22108803_ChIP-Seq_LS180_Human1.32571698
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32047946
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.30515618
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.30387760
59TP53_16413492_ChIP-PET_HCT116_Human1.28791865
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28703375
61CLOCK_20551151_ChIP-Seq_293T_Human1.27007318
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25051877
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.24337534
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23339924
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23233692
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.23028670
67BRD4_25478319_ChIP-Seq_HGPS_Human1.20660943
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20585167
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19469572
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18908644
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18325781
72EWS_26573619_Chip-Seq_HEK293_Human1.18250178
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17566571
74SALL4_22934838_ChIP-ChIP_CD34+_Human1.16466164
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16027307
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.15852120
77FUS_26573619_Chip-Seq_HEK293_Human1.15765951
78AR_25329375_ChIP-Seq_VCAP_Human1.13471112
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12951762
80STAT3_23295773_ChIP-Seq_U87_Human1.12235217
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11412329
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11284506
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11164037
84RUNX2_22187159_ChIP-Seq_PCA_Human1.09850042
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08213307
86CJUN_26792858_Chip-Seq_BT549_Human1.07476942
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07437239
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07437239
89CHD1_26751641_Chip-Seq_LNCaP_Human1.06489972
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05803592
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.05231835
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04767984
93TCF4_23295773_ChIP-Seq_U87_Human1.04106007
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03361359
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02794666
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02582885
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01979190
98GATA1_22025678_ChIP-Seq_K562_Human1.01728286
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01426201
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00910047
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00710862
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00021520
103E2F1_18555785_Chip-Seq_ESCs_Mouse0.99439794
104CMYC_18555785_Chip-Seq_ESCs_Mouse0.97767129
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.97388767
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.96826228
107TCF4_18268006_ChIP-ChIP_LS174T_Human0.96685837
108TAF15_26573619_Chip-Seq_HEK293_Human0.96542783
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96489232
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96383094
111SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96007895
112NFYB_21822215_ChIP-Seq_K562_Human0.95981929
113JUN_21703547_ChIP-Seq_K562_Human0.95788504
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95766628
115TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95764830
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95600943
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92336677
118MYB_26560356_Chip-Seq_TH1_Human0.89264179
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88643396
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88508510
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88349460
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86071834
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84726338
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84318604
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83678796
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82361346
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82301393
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81843705
129KDM5A_27292631_Chip-Seq_BREAST_Human0.80578266
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80455315
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.77834280
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77115727
133SMAD_19615063_ChIP-ChIP_OVARY_Human0.77062754
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.74971897
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74856836
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.74770526
137AR_21572438_ChIP-Seq_LNCaP_Human0.74406145
138FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.73812530
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73469117
140SMAD4_21799915_ChIP-Seq_A2780_Human0.72514303
141MYB_26560356_Chip-Seq_TH2_Human0.70860936
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70527239
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.69867172
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69435265
145GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.68834385
146CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68793783
147SOX9_26525672_Chip-Seq_HEART_Mouse0.68591820
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.68280889
149ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67532698
150TFEB_21752829_ChIP-Seq_HELA_Human0.67303117
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.66979932
152ER_23166858_ChIP-Seq_MCF-7_Human0.66898726
153GATA3_27048872_Chip-Seq_THYMUS_Human0.66459967
154MYB_21317192_ChIP-Seq_ERMYB_Mouse0.66344464
155CDX2_22108803_ChIP-Seq_LS180_Human0.66231017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.54043031
2MP0005423_abnormal_somatic_nervous3.66782104
3MP0010352_gastrointestinal_tract_polyps3.24517473
4MP0010094_abnormal_chromosome_stability3.10715074
5MP0003705_abnormal_hypodermis_morpholog2.95136207
6MP0010307_abnormal_tumor_latency2.92529701
7MP0008057_abnormal_DNA_replication2.84933892
8MP0003300_gastrointestinal_ulcer2.73422998
9MP0008877_abnormal_DNA_methylation2.69803174
10MP0010234_abnormal_vibrissa_follicle2.54616029
11MP0005410_abnormal_fertilization2.29158537
12MP0002877_abnormal_melanocyte_morpholog2.27437683
13MP0001730_embryonic_growth_arrest2.25090814
14MP0003111_abnormal_nucleus_morphology2.19443603
15MP0005076_abnormal_cell_differentiation2.17980940
16MP0003950_abnormal_plasma_membrane2.17932078
17MP0003221_abnormal_cardiomyocyte_apopto2.13746723
18MP0003121_genomic_imprinting2.09810892
19MP0004084_abnormal_cardiac_muscle2.09673153
20MP0004957_abnormal_blastocyst_morpholog2.03421722
21MP0003123_paternal_imprinting1.98791144
22MP0003077_abnormal_cell_cycle1.94264903
23MP0003693_abnormal_embryo_hatching1.91968780
24MP0003787_abnormal_imprinting1.90417249
25MP0004264_abnormal_extraembryonic_tissu1.86856963
26MP0008438_abnormal_cutaneous_collagen1.85528579
27MP0005623_abnormal_meninges_morphology1.83692889
28MP0000537_abnormal_urethra_morphology1.81164964
29MP0003091_abnormal_cell_migration1.78450486
30MP0003943_abnormal_hepatobiliary_system1.76671921
31MP0001299_abnormal_eye_distance/1.76583263
32MP0004197_abnormal_fetal_growth/weight/1.72576994
33MP0003984_embryonic_growth_retardation1.63945152
34MP0002088_abnormal_embryonic_growth/wei1.63586357
35MP0005380_embryogenesis_phenotype1.61312931
36MP0001672_abnormal_embryogenesis/_devel1.61312931
37MP0002086_abnormal_extraembryonic_tissu1.57763939
38MP0009780_abnormal_chondrocyte_physiolo1.57703365
39MP0002084_abnormal_developmental_patter1.52413457
40MP0004808_abnormal_hematopoietic_stem1.51767770
41MP0002396_abnormal_hematopoietic_system1.51603315
42MP0000350_abnormal_cell_proliferation1.49676196
43MP0001697_abnormal_embryo_size1.45096848
44MP0002102_abnormal_ear_morphology1.43597146
45MP0004233_abnormal_muscle_weight1.41803824
46MP0002254_reproductive_system_inflammat1.39400066
47MP0003890_abnormal_embryonic-extraembry1.39116125
48MP0003566_abnormal_cell_adhesion1.38960574
49MP0009703_decreased_birth_body1.37865034
50MP0001661_extended_life_span1.34765915
51MP0003718_maternal_effect1.33659787
52MP0004185_abnormal_adipocyte_glucose1.33626884
53MP0004134_abnormal_chest_morphology1.33206371
54MP0001929_abnormal_gametogenesis1.31643369
55MP0008007_abnormal_cellular_replicative1.28450050
56MP0003632_abnormal_nervous_system1.24539877
57MP0004145_abnormal_muscle_electrophysio1.24419841
58MP0002085_abnormal_embryonic_tissue1.21916581
59MP0004484_altered_response_of1.21915493
60MP0003763_abnormal_thymus_physiology1.21402469
61MP0003045_fibrosis1.19724992
62MP0003698_abnormal_male_reproductive1.18667028
63MP0006054_spinal_hemorrhage1.18185083
64* MP0002080_prenatal_lethality1.17415044
65MP0000427_abnormal_hair_cycle1.16155456
66MP0003646_muscle_fatigue1.15712505
67MP0000428_abnormal_craniofacial_morphol1.14056528
68MP0002166_altered_tumor_susceptibility1.13969520
69MP0010678_abnormal_skin_adnexa1.11500448
70MP0009672_abnormal_birth_weight1.11142959
71MP0008775_abnormal_heart_ventricle1.10008848
72MP0000733_abnormal_muscle_development1.07495640
73MP0001986_abnormal_taste_sensitivity1.06957355
74MP0005621_abnormal_cell_physiology1.04317396
75MP0001915_intracranial_hemorrhage1.04131373
76MP0009250_abnormal_appendicular_skeleto1.03138797
77MP0005023_abnormal_wound_healing1.02259003
78MP0009697_abnormal_copulation0.99011411
79* MP0002269_muscular_atrophy0.98409886
80MP0004215_abnormal_myocardial_fiber0.97435254
81MP0000015_abnormal_ear_pigmentation0.96609936
82MP0004147_increased_porphyrin_level0.96324683
83MP0003172_abnormal_lysosome_physiology0.96198980
84MP0000371_diluted_coat_color0.95447643
85MP0010368_abnormal_lymphatic_system0.95318100
86MP0008058_abnormal_DNA_repair0.92732260
87MP0002234_abnormal_pharynx_morphology0.92164498
88MP0001145_abnormal_male_reproductive0.91902623
89MP0004036_abnormal_muscle_relaxation0.91804214
90MP0003937_abnormal_limbs/digits/tail_de0.91015120
91MP0002210_abnormal_sex_determination0.90939925
92MP0003115_abnormal_respiratory_system0.90520404
93MP0005384_cellular_phenotype0.90004944
94MP0000003_abnormal_adipose_tissue0.89512835
95MP0003122_maternal_imprinting0.86446534
96MP0002925_abnormal_cardiovascular_devel0.86395556
97MP0003880_abnormal_central_pattern0.85036073
98MP0005266_abnormal_metabolism0.84757348
99MP0000920_abnormal_myelination0.83216480
100MP0001177_atelectasis0.81803071
101MP0003633_abnormal_nervous_system0.81012863
102MP0005310_abnormal_salivary_gland0.80775939
103MP0005187_abnormal_penis_morphology0.80749489
104MP0000762_abnormal_tongue_morphology0.79976229
105MP0008770_decreased_survivor_rate0.78948237
106MP0003252_abnormal_bile_duct0.78687387
107MP0000313_abnormal_cell_death0.78349418
108MP0001348_abnormal_lacrimal_gland0.77983124
109MP0002127_abnormal_cardiovascular_syste0.77678066
110MP0002114_abnormal_axial_skeleton0.77284002
111MP0004742_abnormal_vestibular_system0.77225498
112MP0002896_abnormal_bone_mineralization0.77039072
113MP0008932_abnormal_embryonic_tissue0.76844390
114MP0003567_abnormal_fetal_cardiomyocyte0.76645598
115MP0002161_abnormal_fertility/fecundity0.76087031
116MP0005647_abnormal_sex_gland0.75346806
117MP0001340_abnormal_eyelid_morphology0.74703286
118MP0003935_abnormal_craniofacial_develop0.73505292
119MP0003806_abnormal_nucleotide_metabolis0.73246969
120MP0002282_abnormal_trachea_morphology0.73081308
121MP0000653_abnormal_sex_gland0.72397863
122MP0005408_hypopigmentation0.70688887
123MP0003690_abnormal_glial_cell0.69913124
124MP0000604_amyloidosis0.69490373
125MP0003941_abnormal_skin_development0.69179952
126MP0005171_absent_coat_pigmentation0.68959959
127MP0005395_other_phenotype0.68731856
128MP0001293_anophthalmia0.68532189
129MP0000703_abnormal_thymus_morphology0.68327360
130MP0000383_abnormal_hair_follicle0.68265400
131MP0000516_abnormal_urinary_system0.67468519
132MP0005367_renal/urinary_system_phenotyp0.67468519
133MP0000432_abnormal_head_morphology0.67250737
134MP0002006_tumorigenesis0.66466088
135MP0003868_abnormal_feces_composition0.66297184
136MP0002109_abnormal_limb_morphology0.64813880
137MP0002009_preneoplasia0.64371666
138MP0005666_abnormal_adipose_tissue0.64252862
139MP0001784_abnormal_fluid_regulation0.63993267
140MP0002108_abnormal_muscle_morphology0.63717767
141MP0005377_hearing/vestibular/ear_phenot0.63669487
142MP0003878_abnormal_ear_physiology0.63669487
143MP0003861_abnormal_nervous_system0.62915863
144MP0004859_abnormal_synaptic_plasticity0.62615648
145MP0000747_muscle_weakness0.61956183
146MP0002092_abnormal_eye_morphology0.61751689
147MP0000266_abnormal_heart_morphology0.61150206
148MP0005275_abnormal_skin_tensile0.60708121
149MP0003329_amyloid_beta_deposits0.59189947
150* MP0004811_abnormal_neuron_physiology0.58217660

Predicted human phenotypes

RankGene SetZ-score
1Acute myeloid leukemia (HP:0004808)4.57429310
2Chronic hepatic failure (HP:0100626)3.99099217
3Curly hair (HP:0002212)3.69003498
4Volvulus (HP:0002580)3.67100090
5Carpal bone hypoplasia (HP:0001498)3.46475713
6Macroorchidism (HP:0000053)3.28199000
7Heterotopia (HP:0002282)3.22176004
8Short 4th metacarpal (HP:0010044)3.17259869
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.17259869
10Absent frontal sinuses (HP:0002688)3.08599364
11Thyroiditis (HP:0100646)3.08179819
12Thyroid carcinoma (HP:0002890)3.06215035
13Chromsome breakage (HP:0040012)3.04677481
14Protruding tongue (HP:0010808)3.03825960
15Abnormality of DNA repair (HP:0003254)3.01440834
16Spinal muscular atrophy (HP:0007269)2.89440624
17Metaphyseal dysplasia (HP:0100255)2.85510655
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78327544
19Subacute progressive viral hepatitis (HP:0006572)2.76833445
20Cystic hygroma (HP:0000476)2.72782470
21Deep philtrum (HP:0002002)2.70042582
22Entropion (HP:0000621)2.65158743
23Astrocytoma (HP:0009592)2.63595634
24Abnormality of the astrocytes (HP:0100707)2.63595634
25Fair hair (HP:0002286)2.56804087
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.55785721
27Hip dysplasia (HP:0001385)2.52927833
28Atrophy/Degeneration involving motor neurons (HP:0007373)2.52653254
29Papilledema (HP:0001085)2.48712105
30Truncal obesity (HP:0001956)2.44662665
31Hyperventilation (HP:0002883)2.41144472
32Abnormality of oral frenula (HP:0000190)2.39712870
33Limb hypertonia (HP:0002509)2.39377385
34Ankyloglossia (HP:0010296)2.37025670
35Abnormality of the lower motor neuron (HP:0002366)2.36052642
36Severe combined immunodeficiency (HP:0004430)2.35301402
37Abnormality of the fingertips (HP:0001211)2.34530156
38Abnormality of the 4th metacarpal (HP:0010012)2.34450194
39Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.34377599
40Deviation of the thumb (HP:0009603)2.34263156
41Insidious onset (HP:0003587)2.33129046
42Termporal pattern (HP:0011008)2.33129046
43Small hand (HP:0200055)2.30961593
44Relative macrocephaly (HP:0004482)2.30881520
45Ependymoma (HP:0002888)2.28972502
46Abnormal foot bone ossification (HP:0010675)2.26862574
47Hypopigmentation of the fundus (HP:0007894)2.25781586
48Glioma (HP:0009733)2.25680439
49Sandal gap (HP:0001852)2.25621063
50Obsessive-compulsive behavior (HP:0000722)2.24133835
51High pitched voice (HP:0001620)2.23143570
52Renal cortical cysts (HP:0000803)2.22399211
53Broad alveolar ridges (HP:0000187)2.17195957
54Increased nuchal translucency (HP:0010880)2.17156909
55Proximal placement of thumb (HP:0009623)2.16158704
56Dysmetric saccades (HP:0000641)2.15861597
57Impaired smooth pursuit (HP:0007772)2.15222711
58Cutaneous melanoma (HP:0012056)2.14306267
59Tubulointerstitial nephritis (HP:0001970)2.13048469
60Pancreatic islet-cell hyperplasia (HP:0004510)2.09506515
61Long clavicles (HP:0000890)2.09482059
62Abnormality of ocular smooth pursuit (HP:0000617)2.09383801
63Capillary hemangiomas (HP:0005306)2.08689209
64Thickened helices (HP:0000391)2.07977972
65Retinal dysplasia (HP:0007973)2.02857688
66Difficulty running (HP:0009046)2.02832227
67Aortic aneurysm (HP:0004942)2.01963947
68Hypobetalipoproteinemia (HP:0003563)2.01628376
69Resting tremor (HP:0002322)2.01282237
70Poikiloderma (HP:0001029)2.01078470
71Generalized hypopigmentation of hair (HP:0011358)2.00266005
72Submucous cleft hard palate (HP:0000176)1.98255549
73T lymphocytopenia (HP:0005403)1.97615892
74Increased mean platelet volume (HP:0011877)1.97408909
75Hypoplastic ischia (HP:0003175)1.96179682
76Urinary urgency (HP:0000012)1.95182623
77Nephroblastoma (Wilms tumor) (HP:0002667)1.94978013
78Broad thumb (HP:0011304)1.92706329
79Bell-shaped thorax (HP:0001591)1.91611049
80Narrow palate (HP:0000189)1.90753760
81Spondylolisthesis (HP:0003302)1.89150816
82Abnormality of the ileum (HP:0001549)1.88775846
83Low anterior hairline (HP:0000294)1.88633842
84Abnormality of the calcaneus (HP:0008364)1.87678877
85Drooling (HP:0002307)1.87142745
86Embryonal renal neoplasm (HP:0011794)1.87012403
87Barrel-shaped chest (HP:0001552)1.86734705
88Prominent nose (HP:0000448)1.86330553
89Intestinal atresia (HP:0011100)1.85655540
90Combined immunodeficiency (HP:0005387)1.85631637
91Proximal amyotrophy (HP:0007126)1.83030706
92Rhabdomyosarcoma (HP:0002859)1.82716530
93Hyperkalemia (HP:0002153)1.81520092
94Papillary thyroid carcinoma (HP:0002895)1.81282849
95Intellectual disability, moderate (HP:0002342)1.80356821
96Abnormality of the corticospinal tract (HP:0002492)1.79933511
97Cortical dysplasia (HP:0002539)1.78987252
98Long eyelashes (HP:0000527)1.78302559
99Limited elbow extension (HP:0001377)1.77985002
100Global brain atrophy (HP:0002283)1.77788566
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77387142
102Fibular aplasia (HP:0002990)1.76798616
103Abnormality of the ischium (HP:0003174)1.74662150
104Cerebral aneurysm (HP:0004944)1.74419155
105Pelvic girdle muscle weakness (HP:0003749)1.73916370
106Complete atrioventricular canal defect (HP:0001674)1.72229177
107Myelodysplasia (HP:0002863)1.72105079
108Aqueductal stenosis (HP:0002410)1.71483113
109Abnormality of the renal cortex (HP:0011035)1.69616668
110Neoplasm of the oral cavity (HP:0100649)1.69523049
111Abnormality of T cell number (HP:0011839)1.69148141
112Ectopic kidney (HP:0000086)1.68752840
113Impaired vibration sensation in the lower limbs (HP:0002166)1.68496013
114Abnormality of methionine metabolism (HP:0010901)1.68407049
115Mitral valve prolapse (HP:0001634)1.67997646
116Cutis marmorata (HP:0000965)1.67627331
117Medulloblastoma (HP:0002885)1.67540279
118Hypoplastic labia majora (HP:0000059)1.66574507
119Midline defect of the nose (HP:0004122)1.66175456
120Flat acetabular roof (HP:0003180)1.65564912
121Abnormal platelet volume (HP:0011876)1.64771773
122Cerebellar dysplasia (HP:0007033)1.63965706
123Broad-based gait (HP:0002136)1.63805068
124Metaphyseal cupping (HP:0003021)1.63613475
125Cafe-au-lait spot (HP:0000957)1.63305864
126Abnormality of the frontal sinuses (HP:0002687)1.61580164
127Freckling (HP:0001480)1.61304386
128Excessive salivation (HP:0003781)1.61050327
129Bifid tongue (HP:0010297)1.60640082
130Abnormality of the costochondral junction (HP:0000919)1.60599481
131Scanning speech (HP:0002168)1.60356271
132Bowel diverticulosis (HP:0005222)1.59750405
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.59731075
134Exotropia (HP:0000577)1.59429803
135Meckel diverticulum (HP:0002245)1.58704555
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.57956482
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57956482
138Skull defect (HP:0001362)1.57009623
139Transitional cell carcinoma of the bladder (HP:0006740)1.56953207
140Renovascular hypertension (HP:0100817)1.56782931
141Biliary tract neoplasm (HP:0100574)1.56636204
142Spastic gait (HP:0002064)1.56268047
143Abnormality of chromosome stability (HP:0003220)1.56217989
144Fibrous tissue neoplasm (HP:0012316)1.55695818
145Abnormality of macular pigmentation (HP:0008002)1.55687509
146Gastrointestinal carcinoma (HP:0002672)1.55608007
147Malignant gastrointestinal tract tumors (HP:0006749)1.55608007
148Pheochromocytoma (HP:0002666)1.55607032
149Abnormality of chromosome segregation (HP:0002916)1.55605615
150Open mouth (HP:0000194)1.54856901
151Aplasia/Hypoplasia of the sternum (HP:0006714)1.54776916
152Short ribs (HP:0000773)1.53960844
153Broad palm (HP:0001169)1.53567396
154Distal upper limb amyotrophy (HP:0007149)1.53395095
155Upper limb amyotrophy (HP:0009129)1.53395095
156Acanthocytosis (HP:0001927)1.53267512
157Aneurysm (HP:0002617)1.53154224
158Amyotrophic lateral sclerosis (HP:0007354)1.52946051
159Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.52805647
160Limited hip movement (HP:0008800)1.52717678
161Absent eyebrow (HP:0002223)1.52397749
162Abnormal biliary tract morphology (HP:0012440)1.52197835
163Large earlobe (HP:0009748)1.52123552
164Rhizomelia (HP:0008905)1.52082871
165Cervical subluxation (HP:0003308)1.52073662
166Fetal akinesia sequence (HP:0001989)1.51908586
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.51509238
168Impulsivity (HP:0100710)1.51508917
169Hand muscle atrophy (HP:0009130)1.51115995
170Small epiphyses (HP:0010585)1.50764610
171Upper limb muscle weakness (HP:0003484)1.50689463
172Basal cell carcinoma (HP:0002671)1.49766729
173Lip pit (HP:0100267)1.49257232
174Ectropion (HP:0000656)1.47025856
175Neoplasm of the tracheobronchial system (HP:0100552)1.46857870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.11012677
2CDC72.98672507
3NUAK12.78370933
4SCYL22.67492344
5PRKD32.62944520
6PDK42.59460275
7PDK32.59460275
8PLK42.54539299
9PKN22.33348554
10TAOK32.19611594
11EIF2AK32.12625867
12MELK2.10721272
13NEK21.98006170
14BRD41.97496151
15LATS11.95766474
16EEF2K1.91632411
17SRPK11.74920126
18MST41.74034244
19NEK11.72008601
20TTK1.69907219
21DYRK21.65377395
22FRK1.58972139
23ERBB31.55574805
24PDK21.55527702
25PDGFRA1.55282161
26PASK1.51733646
27HIPK21.48762738
28MET1.48211899
29TTN1.47944931
30INSRR1.46166856
31STK38L1.42667529
32SIK11.41327251
33AKT31.39482491
34ATR1.39466138
35BRSK21.39008722
36FGFR21.38463067
37TNIK1.37580380
38TRIM281.35092555
39BCR1.33315638
40ACVR1B1.25752061
41MKNK11.23908794
42PNCK1.23262557
43CAMK1D1.22911595
44STK101.22880952
45MKNK21.21874054
46ALK1.21338966
47MAP3K121.19209942
48PTK61.17673415
49FLT31.17241712
50ZAK1.16648358
51PLK31.16094719
52PDGFRB1.15782641
53CHEK11.15030029
54PBK1.11696475
55TSSK61.10085780
56STK31.09772798
57CAMK1G1.09566933
58WNK31.07540750
59MAP4K21.06868978
60FGFR11.06296770
61MTOR1.04111685
62ATM1.03872293
63DDR20.99078305
64MAP3K80.98635094
65STK380.97868116
66RAF10.97780974
67JAK30.95719453
68TRIB30.95181677
69FGFR30.93520169
70TESK10.93347060
71SGK4940.91657362
72SGK2230.91657362
73WEE10.91633095
74RPS6KB10.90435202
75MAP3K40.90037306
76PAK30.88998337
77YES10.88360187
78FER0.88112278
79CASK0.87715564
80PAK20.86678193
81TEC0.86249909
82OBSCN0.86127137
83STK390.85274276
84CDK60.84512382
85RET0.82593679
86PDK10.82544199
87CSNK1D0.81120653
88TIE10.80846662
89EPHA30.79806259
90PRKCH0.79499966
91MAP3K100.78643509
92CDK40.76949347
93TYRO30.76115449
94MAP3K90.73698312
95JAK10.71607386
96BMPR1B0.70845985
97CHEK20.70658676
98CSNK1A1L0.70336421
99CDK20.70060562
100MARK10.69588228
101CDK10.69582237
102PIK3CG0.69284987
103NLK0.68650696
104PRKAA20.66232972
105MAP3K20.65738041
106BRAF0.65598186
107SGK30.65392094
108PRKDC0.64658526
109KSR20.63844755
110BRSK10.63499891
111PAK60.61570615
112KSR10.59681523
113WNK10.59099509
114BMX0.58314185
115MAP3K70.58151415
116EIF2AK20.57819164
117PLK10.55853104
118RIPK10.53529574
119PDPK10.53137822
120ICK0.52621348
121CHUK0.52245921
122RPS6KB20.50440538
123MAP3K130.49849630
124TGFBR10.49650121
125PTK2B0.48695174
126PLK20.48070631
127NEK60.47814024
128CSNK1G20.47475257
129AURKB0.47453241
130CDK90.46579633
131CSNK1E0.46439097
132MAPK140.44383225
133TRPM70.43688872
134CDC42BPA0.42898874
135SGK10.42786702
136MAPK100.42240901
137CLK10.41649861
138MUSK0.41028775
139GSK3B0.40804271
140NTRK30.40705187
141INSR0.40213948
142STK40.39066153
143PTK20.38050388
144SGK20.37791023
145TGFBR20.37748822
146NME10.36851898
147TAF10.36029399
148PRKCE0.34643142
149ITK0.34301216
150RPS6KA40.34185251
151PRKAA10.33914721
152CSNK1G10.33118978

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.16510574
2Non-homologous end-joining_Homo sapiens_hsa034502.00901184
3Lysine degradation_Homo sapiens_hsa003101.90144645
4Circadian rhythm_Homo sapiens_hsa047101.89746516
5Propanoate metabolism_Homo sapiens_hsa006401.86097354
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80576750
7mTOR signaling pathway_Homo sapiens_hsa041501.79253377
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.77339544
9Dorso-ventral axis formation_Homo sapiens_hsa043201.74634463
10Cell cycle_Homo sapiens_hsa041101.71234334
11Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70867518
12mRNA surveillance pathway_Homo sapiens_hsa030151.64291949
13Regulation of autophagy_Homo sapiens_hsa041401.61344261
14RNA transport_Homo sapiens_hsa030131.61057415
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.57774429
16Selenocompound metabolism_Homo sapiens_hsa004501.57679987
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55262725
18Oocyte meiosis_Homo sapiens_hsa041141.50522621
19Basal transcription factors_Homo sapiens_hsa030221.49476648
20One carbon pool by folate_Homo sapiens_hsa006701.48188674
21Systemic lupus erythematosus_Homo sapiens_hsa053221.40260650
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37508945
23Nucleotide excision repair_Homo sapiens_hsa034201.33318612
24Type II diabetes mellitus_Homo sapiens_hsa049301.31949929
25MicroRNAs in cancer_Homo sapiens_hsa052061.31197815
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29624829
27Glioma_Homo sapiens_hsa052141.23209173
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22665467
29Viral carcinogenesis_Homo sapiens_hsa052031.22563628
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22269394
31Long-term potentiation_Homo sapiens_hsa047201.20789187
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19324898
33Chronic myeloid leukemia_Homo sapiens_hsa052201.17307105
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14906479
35Mismatch repair_Homo sapiens_hsa034301.13968884
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12788569
37Glucagon signaling pathway_Homo sapiens_hsa049221.08766800
38DNA replication_Homo sapiens_hsa030301.04475642
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04384017
40Proteoglycans in cancer_Homo sapiens_hsa052051.03661891
41Alcoholism_Homo sapiens_hsa050341.03562290
42Estrogen signaling pathway_Homo sapiens_hsa049151.02275842
43Legionellosis_Homo sapiens_hsa051341.01735844
44Non-small cell lung cancer_Homo sapiens_hsa052231.00987943
45Focal adhesion_Homo sapiens_hsa045101.00533205
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00493450
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99070903
48Adherens junction_Homo sapiens_hsa045200.98975803
49Colorectal cancer_Homo sapiens_hsa052100.98330882
50Renal cell carcinoma_Homo sapiens_hsa052110.98304288
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98279084
52Endometrial cancer_Homo sapiens_hsa052130.97670132
53AMPK signaling pathway_Homo sapiens_hsa041520.94035614
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93662448
55Small cell lung cancer_Homo sapiens_hsa052220.92866420
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90765340
57Prostate cancer_Homo sapiens_hsa052150.90702939
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90485496
59ErbB signaling pathway_Homo sapiens_hsa040120.87813606
60Thyroid hormone synthesis_Homo sapiens_hsa049180.86049174
61Pancreatic cancer_Homo sapiens_hsa052120.85781254
62Insulin resistance_Homo sapiens_hsa049310.85687839
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84424086
64RNA degradation_Homo sapiens_hsa030180.80093711
65T cell receptor signaling pathway_Homo sapiens_hsa046600.80050398
66Olfactory transduction_Homo sapiens_hsa047400.79735190
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79493554
68ECM-receptor interaction_Homo sapiens_hsa045120.78224436
69Arginine biosynthesis_Homo sapiens_hsa002200.78221081
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78162951
71Protein export_Homo sapiens_hsa030600.78079844
72Antigen processing and presentation_Homo sapiens_hsa046120.77984576
73N-Glycan biosynthesis_Homo sapiens_hsa005100.76505381
74Long-term depression_Homo sapiens_hsa047300.76361566
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76149618
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72587666
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71213406
78Taste transduction_Homo sapiens_hsa047420.70228173
79Choline metabolism in cancer_Homo sapiens_hsa052310.68992864
80Caffeine metabolism_Homo sapiens_hsa002320.68659232
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67726633
82ABC transporters_Homo sapiens_hsa020100.66100981
83Insulin signaling pathway_Homo sapiens_hsa049100.65971914
84Pyruvate metabolism_Homo sapiens_hsa006200.65926309
85Amphetamine addiction_Homo sapiens_hsa050310.63597767
86VEGF signaling pathway_Homo sapiens_hsa043700.63437363
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63395229
88Platelet activation_Homo sapiens_hsa046110.63125820
89Fatty acid biosynthesis_Homo sapiens_hsa000610.62797056
90Biosynthesis of amino acids_Homo sapiens_hsa012300.62209749
91B cell receptor signaling pathway_Homo sapiens_hsa046620.62109723
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.61052052
93HTLV-I infection_Homo sapiens_hsa051660.60869418
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.60332324
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60312726
96Vitamin digestion and absorption_Homo sapiens_hsa049770.58932002
97Spliceosome_Homo sapiens_hsa030400.58279888
98Hepatitis B_Homo sapiens_hsa051610.58067269
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58008177
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57711697
101Fanconi anemia pathway_Homo sapiens_hsa034600.55784769
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55559992
103Dopaminergic synapse_Homo sapiens_hsa047280.54300457
104Renin secretion_Homo sapiens_hsa049240.54182995
105FoxO signaling pathway_Homo sapiens_hsa040680.53991934
106Insulin secretion_Homo sapiens_hsa049110.53826577
107Thyroid cancer_Homo sapiens_hsa052160.53721916
108Hippo signaling pathway_Homo sapiens_hsa043900.52104055
109Primary immunodeficiency_Homo sapiens_hsa053400.52072754
110Nicotine addiction_Homo sapiens_hsa050330.51136233
111Homologous recombination_Homo sapiens_hsa034400.50913540
112Serotonergic synapse_Homo sapiens_hsa047260.50886460
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50160891
114Tight junction_Homo sapiens_hsa045300.49310536
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48963647
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48557923
117p53 signaling pathway_Homo sapiens_hsa041150.48420668
118Glutamatergic synapse_Homo sapiens_hsa047240.47613783
119Melanoma_Homo sapiens_hsa052180.47570082
120Glutathione metabolism_Homo sapiens_hsa004800.47016129
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.46622905
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45912211
123HIF-1 signaling pathway_Homo sapiens_hsa040660.44868105
124Inositol phosphate metabolism_Homo sapiens_hsa005620.44695611
125Glycerolipid metabolism_Homo sapiens_hsa005610.44511302
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44068139
127MAPK signaling pathway_Homo sapiens_hsa040100.43963627
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43538745
129Fatty acid metabolism_Homo sapiens_hsa012120.43160512
130Bile secretion_Homo sapiens_hsa049760.43016553
131Prolactin signaling pathway_Homo sapiens_hsa049170.42996626
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.42868381
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42811775
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.42700905
135Purine metabolism_Homo sapiens_hsa002300.41706863
136TGF-beta signaling pathway_Homo sapiens_hsa043500.41567260
137Hedgehog signaling pathway_Homo sapiens_hsa043400.41074692
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.40762457
139Steroid biosynthesis_Homo sapiens_hsa001000.40362473
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.40297772
141Dilated cardiomyopathy_Homo sapiens_hsa054140.39163731
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.38708103
143Oxytocin signaling pathway_Homo sapiens_hsa049210.38412196
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36125054

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