Rank | Gene Set | Z-score |
---|---|---|
1 | purine nucleobase biosynthetic process (GO:0009113) | 4.87056376 |
2 | nucleobase biosynthetic process (GO:0046112) | 4.81918739 |
3 | formation of translation preinitiation complex (GO:0001731) | 4.72287998 |
4 | ribosome assembly (GO:0042255) | 4.54136807 |
5 | mitotic metaphase plate congression (GO:0007080) | 4.47510841 |
6 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.29928008 |
7 | maturation of SSU-rRNA (GO:0030490) | 4.28313798 |
8 | ribosome biogenesis (GO:0042254) | 4.26658019 |
9 | DNA replication checkpoint (GO:0000076) | 4.19436628 |
10 | DNA replication initiation (GO:0006270) | 4.19164723 |
11 | mitotic nuclear envelope disassembly (GO:0007077) | 4.09811941 |
12 | DNA strand elongation (GO:0022616) | 4.07542217 |
13 | nuclear pore organization (GO:0006999) | 4.07112886 |
14 | establishment of integrated proviral latency (GO:0075713) | 4.00004753 |
15 | DNA deamination (GO:0045006) | 3.98264257 |
16 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.91429833 |
17 | protein localization to kinetochore (GO:0034501) | 3.89789601 |
18 | metaphase plate congression (GO:0051310) | 3.84151266 |
19 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.83504233 |
20 | nuclear pore complex assembly (GO:0051292) | 3.81437911 |
21 | IMP biosynthetic process (GO:0006188) | 3.79000489 |
22 | nuclear envelope disassembly (GO:0051081) | 3.78235046 |
23 | membrane disassembly (GO:0030397) | 3.78235046 |
24 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.77836455 |
25 | rRNA methylation (GO:0031167) | 3.74959526 |
26 | cullin deneddylation (GO:0010388) | 3.71719996 |
27 | regulation of spindle organization (GO:0090224) | 3.70009883 |
28 | ribosomal large subunit biogenesis (GO:0042273) | 3.68024131 |
29 | CENP-A containing nucleosome assembly (GO:0034080) | 3.65607952 |
30 | telomere maintenance via recombination (GO:0000722) | 3.62118859 |
31 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.61447224 |
32 | DNA unwinding involved in DNA replication (GO:0006268) | 3.57802154 |
33 | chromatin remodeling at centromere (GO:0031055) | 3.57688813 |
34 | rRNA processing (GO:0006364) | 3.55931094 |
35 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.55857153 |
36 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.55857153 |
37 | proteasome assembly (GO:0043248) | 3.55546890 |
38 | ribosomal small subunit assembly (GO:0000028) | 3.55382894 |
39 | transcription from mitochondrial promoter (GO:0006390) | 3.52244716 |
40 | chaperone-mediated protein transport (GO:0072321) | 3.51760043 |
41 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.45221506 |
42 | protein deneddylation (GO:0000338) | 3.44624893 |
43 | rRNA metabolic process (GO:0016072) | 3.44238667 |
44 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.43261535 |
45 | mitotic recombination (GO:0006312) | 3.42684916 |
46 | IMP metabolic process (GO:0046040) | 3.39765746 |
47 | folic acid metabolic process (GO:0046655) | 3.39263770 |
48 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.38187087 |
49 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.35731434 |
50 | spliceosomal snRNP assembly (GO:0000387) | 3.35621027 |
51 | rRNA modification (GO:0000154) | 3.34924208 |
52 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.33854526 |
53 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.33535381 |
54 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.33535381 |
55 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.32848103 |
56 | establishment of chromosome localization (GO:0051303) | 3.32832077 |
57 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.32784477 |
58 | DNA replication-independent nucleosome organization (GO:0034724) | 3.32784477 |
59 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.32690672 |
60 | protein localization to chromosome, centromeric region (GO:0071459) | 3.32470840 |
61 | regulation of centriole replication (GO:0046599) | 3.31801774 |
62 | termination of RNA polymerase III transcription (GO:0006386) | 3.31424905 |
63 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.31424905 |
64 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.31385635 |
65 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.31244302 |
66 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.27847726 |
67 | telomere maintenance via telomere lengthening (GO:0010833) | 3.26479416 |
68 | DNA double-strand break processing (GO:0000729) | 3.26082913 |
69 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.25837565 |
70 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.25837565 |
71 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.25837565 |
72 | pseudouridine synthesis (GO:0001522) | 3.25594295 |
73 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.25228668 |
74 | DNA damage response, detection of DNA damage (GO:0042769) | 3.24441315 |
75 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.24321716 |
76 | mitochondrial RNA metabolic process (GO:0000959) | 3.24304632 |
77 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.23344886 |
78 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.23344886 |
79 | histone mRNA metabolic process (GO:0008334) | 3.22356916 |
80 | kinetochore organization (GO:0051383) | 3.20730531 |
81 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.20472835 |
82 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.20472835 |
83 | translational initiation (GO:0006413) | 3.19302606 |
84 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.18107392 |
85 | positive regulation of chromosome segregation (GO:0051984) | 3.17273424 |
86 | sister chromatid segregation (GO:0000819) | 3.16422280 |
87 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.16369918 |
88 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.15938269 |
89 | pore complex assembly (GO:0046931) | 3.15093382 |
90 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.14986083 |
91 | non-recombinational repair (GO:0000726) | 3.14986083 |
92 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.13535296 |
93 | DNA ligation (GO:0006266) | 3.13455728 |
94 | histone exchange (GO:0043486) | 3.13334867 |
95 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.11324485 |
96 | protein targeting to mitochondrion (GO:0006626) | 3.11149195 |
97 | regulation of mitochondrial translation (GO:0070129) | 3.10545358 |
98 | regulation of helicase activity (GO:0051095) | 3.09885153 |
99 | 7-methylguanosine mRNA capping (GO:0006370) | 3.09514948 |
100 | regulation of mitotic spindle organization (GO:0060236) | 3.08887669 |
101 | regulation of ligase activity (GO:0051340) | 3.08705275 |
102 | ribosomal small subunit biogenesis (GO:0042274) | 3.08562516 |
103 | cell cycle G1/S phase transition (GO:0044843) | 3.08366659 |
104 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.08366659 |
105 | translational termination (GO:0006415) | 3.06769267 |
106 | 7-methylguanosine RNA capping (GO:0009452) | 3.03882626 |
107 | RNA capping (GO:0036260) | 3.03882626 |
108 | negative regulation of ligase activity (GO:0051352) | 3.03624602 |
109 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.03624602 |
110 | viral transcription (GO:0019083) | 3.01806646 |
111 | termination of RNA polymerase I transcription (GO:0006363) | 3.00576190 |
112 | transcription from RNA polymerase I promoter (GO:0006360) | 3.00471985 |
113 | spindle checkpoint (GO:0031577) | 3.00102232 |
114 | nuclear envelope organization (GO:0006998) | 2.99715003 |
115 | kinetochore assembly (GO:0051382) | 2.98849932 |
116 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.98098801 |
117 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.97292125 |
118 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.96712973 |
119 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.96597409 |
120 | negative regulation of chromosome segregation (GO:0051985) | 2.96143162 |
121 | maturation of 5.8S rRNA (GO:0000460) | 2.96054583 |
122 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.93889517 |
123 | negative regulation of sister chromatid segregation (GO:0033046) | 2.93889517 |
124 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.93889517 |
125 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.93889517 |
126 | mitotic spindle checkpoint (GO:0071174) | 2.91044880 |
127 | mitotic spindle assembly checkpoint (GO:0007094) | 2.90832710 |
128 | translational elongation (GO:0006414) | 2.90752856 |
129 | regulation of chromosome segregation (GO:0051983) | 2.89840956 |
130 | regulation of translation in response to stress (GO:0043555) | 2.89547024 |
131 | mitotic sister chromatid segregation (GO:0000070) | 2.89303269 |
132 | spindle assembly checkpoint (GO:0071173) | 2.89161339 |
133 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.86093601 |
134 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.85320139 |
135 | cellular component biogenesis (GO:0044085) | 2.84270245 |
136 | positive regulation of ligase activity (GO:0051351) | 2.82403586 |
137 | regulation of centrosome cycle (GO:0046605) | 2.82189520 |
138 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.81289803 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.58470185 |
2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.37922070 |
3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.67899830 |
4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.45753192 |
5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.41115226 |
6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.33022440 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.09174116 |
8 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.08408759 |
9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.01165367 |
10 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.00129677 |
11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.97910115 |
12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.92881747 |
13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.88070600 |
14 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.86733730 |
15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.85866762 |
16 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.42089156 |
17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.35556075 |
18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.29636438 |
19 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.29537736 |
20 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.28859810 |
21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.21910667 |
22 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.20127453 |
23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.13249398 |
24 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.12165433 |
25 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.06504097 |
26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.04773405 |
27 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.99095475 |
28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.98170251 |
29 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.95732051 |
30 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.94791633 |
31 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.94775637 |
32 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.86873989 |
33 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.80997196 |
34 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.80443882 |
35 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.79569855 |
36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78030571 |
37 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.77161650 |
38 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.75934353 |
39 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.72121284 |
40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.70271877 |
41 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.69649844 |
42 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.68222408 |
43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.65078420 |
44 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.58924393 |
45 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.57637135 |
46 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.54469511 |
47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.53611838 |
48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.52481995 |
49 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.49062032 |
50 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49061373 |
51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.46811821 |
52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.46004918 |
53 | MYC_22102868_ChIP-Seq_BL_Human | 1.43544865 |
54 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.43280432 |
55 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.35105817 |
56 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.31179441 |
57 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30242765 |
58 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.28514460 |
59 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.28394591 |
60 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.26535327 |
61 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.24678985 |
62 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.24415705 |
63 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.23459296 |
64 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.21592576 |
65 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.21193878 |
66 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.19756242 |
67 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.19721690 |
68 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.18729290 |
69 | EWS_26573619_Chip-Seq_HEK293_Human | 1.15823637 |
70 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13552348 |
71 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.12912206 |
72 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.12829245 |
73 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.12520130 |
74 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.11009830 |
75 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08304976 |
76 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.06852891 |
77 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.04237251 |
78 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.03275229 |
79 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.02526838 |
80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.02281103 |
81 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02063510 |
82 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.01558394 |
83 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.01413460 |
84 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.00552725 |
85 | FUS_26573619_Chip-Seq_HEK293_Human | 0.99592682 |
86 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.99418878 |
87 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.97684999 |
88 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.96153681 |
89 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.96062727 |
90 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.94923271 |
91 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.92383768 |
92 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.92238801 |
93 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.90988724 |
94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.90621990 |
95 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.88197508 |
96 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.86935938 |
97 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86916091 |
98 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86123553 |
99 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.85288781 |
100 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.83263357 |
101 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.82827097 |
102 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.80267187 |
103 | VDR_22108803_ChIP-Seq_LS180_Human | 0.77114556 |
104 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.76666539 |
105 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.76544991 |
106 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.75605812 |
107 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.72818637 |
108 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.72800660 |
109 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.72091965 |
110 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.72044115 |
111 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.71789708 |
112 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71596538 |
113 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.71570100 |
114 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.71011864 |
115 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.70917963 |
116 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.69089325 |
117 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.64721412 |
118 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.63303990 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 5.77946291 |
2 | MP0004957_abnormal_blastocyst_morpholog | 4.43782109 |
3 | MP0010094_abnormal_chromosome_stability | 4.26960070 |
4 | MP0003111_abnormal_nucleus_morphology | 4.22907164 |
5 | MP0008057_abnormal_DNA_replication | 4.08342135 |
6 | MP0003077_abnormal_cell_cycle | 3.85740228 |
7 | MP0008058_abnormal_DNA_repair | 3.40779355 |
8 | MP0008007_abnormal_cellular_replicative | 2.81351333 |
9 | MP0008932_abnormal_embryonic_tissue | 2.55952049 |
10 | MP0003123_paternal_imprinting | 2.42151737 |
11 | MP0001730_embryonic_growth_arrest | 2.40701117 |
12 | MP0002396_abnormal_hematopoietic_system | 2.31428832 |
13 | MP0000350_abnormal_cell_proliferation | 2.16955725 |
14 | MP0003806_abnormal_nucleotide_metabolis | 2.12849262 |
15 | MP0010352_gastrointestinal_tract_polyps | 2.05278537 |
16 | MP0006292_abnormal_olfactory_placode | 2.03642767 |
17 | MP0003786_premature_aging | 2.01763882 |
18 | MP0003718_maternal_effect | 1.96601554 |
19 | MP0009333_abnormal_splenocyte_physiolog | 1.84719472 |
20 | MP0008877_abnormal_DNA_methylation | 1.83896110 |
21 | MP0001672_abnormal_embryogenesis/_devel | 1.73315541 |
22 | MP0005380_embryogenesis_phenotype | 1.73315541 |
23 | MP0001697_abnormal_embryo_size | 1.71497477 |
24 | MP0010307_abnormal_tumor_latency | 1.67896419 |
25 | MP0000490_abnormal_crypts_of | 1.62612141 |
26 | MP0003984_embryonic_growth_retardation | 1.59880291 |
27 | MP0002102_abnormal_ear_morphology | 1.58093022 |
28 | MP0002088_abnormal_embryonic_growth/wei | 1.55194532 |
29 | MP0003567_abnormal_fetal_cardiomyocyte | 1.54084328 |
30 | MP0002080_prenatal_lethality | 1.53652731 |
31 | MP0000372_irregular_coat_pigmentation | 1.47110389 |
32 | MP0002019_abnormal_tumor_incidence | 1.39491009 |
33 | MP0000313_abnormal_cell_death | 1.39345894 |
34 | MP0005397_hematopoietic_system_phenotyp | 1.34779602 |
35 | MP0001545_abnormal_hematopoietic_system | 1.34779602 |
36 | MP0005410_abnormal_fertilization | 1.34758402 |
37 | MP0004808_abnormal_hematopoietic_stem | 1.34528726 |
38 | MP0002086_abnormal_extraembryonic_tissu | 1.34125992 |
39 | MP0004197_abnormal_fetal_growth/weight/ | 1.31009785 |
40 | MP0002085_abnormal_embryonic_tissue | 1.30601681 |
41 | MP0003950_abnormal_plasma_membrane | 1.30315669 |
42 | MP0003186_abnormal_redox_activity | 1.28084772 |
43 | MP0002084_abnormal_developmental_patter | 1.21079284 |
44 | MP0003221_abnormal_cardiomyocyte_apopto | 1.17266306 |
45 | MP0002210_abnormal_sex_determination | 1.15568240 |
46 | MP0003763_abnormal_thymus_physiology | 1.15562950 |
47 | MP0002398_abnormal_bone_marrow | 1.08490615 |
48 | MP0001293_anophthalmia | 1.05415749 |
49 | MP0002722_abnormal_immune_system | 1.04883918 |
50 | MP0002163_abnormal_gland_morphology | 1.03185244 |
51 | MP0004147_increased_porphyrin_level | 1.01695940 |
52 | MP0005076_abnormal_cell_differentiation | 1.01498858 |
53 | MP0001145_abnormal_male_reproductive | 1.00482973 |
54 | MP0000358_abnormal_cell_content/ | 1.00346910 |
55 | MP0000689_abnormal_spleen_morphology | 0.98837015 |
56 | MP0008995_early_reproductive_senescence | 0.98487658 |
57 | MP0001853_heart_inflammation | 0.97485663 |
58 | MP0000858_altered_metastatic_potential | 0.97183072 |
59 | MP0000703_abnormal_thymus_morphology | 0.95709148 |
60 | MP0005084_abnormal_gallbladder_morpholo | 0.93775181 |
61 | MP0008789_abnormal_olfactory_epithelium | 0.90247408 |
62 | MP0005379_endocrine/exocrine_gland_phen | 0.89717287 |
63 | MP0001764_abnormal_homeostasis | 0.89390556 |
64 | MP0002429_abnormal_blood_cell | 0.89329312 |
65 | MP0005023_abnormal_wound_healing | 0.88950944 |
66 | MP0006072_abnormal_retinal_apoptosis | 0.88193661 |
67 | MP0001929_abnormal_gametogenesis | 0.87616480 |
68 | MP0005408_hypopigmentation | 0.87406433 |
69 | MP0001835_abnormal_antigen_presentation | 0.87350631 |
70 | MP0000653_abnormal_sex_gland | 0.84687603 |
71 | MP0002132_abnormal_respiratory_system | 0.84629092 |
72 | MP0003315_abnormal_perineum_morphology | 0.84302263 |
73 | MP0005384_cellular_phenotype | 0.83808862 |
74 | MP0002254_reproductive_system_inflammat | 0.83361015 |
75 | MP0002938_white_spotting | 0.83316069 |
76 | MP0001727_abnormal_embryo_implantation | 0.82691881 |
77 | MP0005075_abnormal_melanosome_morpholog | 0.82212273 |
78 | MP0005621_abnormal_cell_physiology | 0.81092628 |
79 | MP0009697_abnormal_copulation | 0.80334860 |
80 | MP0003566_abnormal_cell_adhesion | 0.80313786 |
81 | MP0008260_abnormal_autophagy | 0.80158061 |
82 | MP0003698_abnormal_male_reproductive | 0.79735160 |
83 | MP0006036_abnormal_mitochondrial_physio | 0.79100681 |
84 | MP0003436_decreased_susceptibility_to | 0.78939140 |
85 | MP0003121_genomic_imprinting | 0.78831172 |
86 | MP0001529_abnormal_vocalization | 0.78672403 |
87 | MP0000716_abnormal_immune_system | 0.78558053 |
88 | MP0001661_extended_life_span | 0.77735062 |
89 | MP0001119_abnormal_female_reproductive | 0.77667596 |
90 | MP0009672_abnormal_birth_weight | 0.77220062 |
91 | MP0000750_abnormal_muscle_regeneration | 0.76221760 |
92 | MP0001188_hyperpigmentation | 0.75926226 |
93 | MP0001881_abnormal_mammary_gland | 0.75736026 |
94 | MP0002160_abnormal_reproductive_system | 0.74317262 |
95 | MP0004264_abnormal_extraembryonic_tissu | 0.74274296 |
96 | MP0001542_abnormal_bone_strength | 0.74184055 |
97 | MP0006054_spinal_hemorrhage | 0.73521545 |
98 | MP0001286_abnormal_eye_development | 0.73321386 |
99 | MP0003890_abnormal_embryonic-extraembry | 0.73012754 |
100 | MP0002234_abnormal_pharynx_morphology | 0.72780316 |
101 | MP0003937_abnormal_limbs/digits/tail_de | 0.72242517 |
102 | MP0004084_abnormal_cardiac_muscle | 0.71996702 |
103 | MP0003699_abnormal_female_reproductive | 0.71673004 |
104 | MP0005671_abnormal_response_to | 0.71380475 |
105 | MP0010030_abnormal_orbit_morphology | 0.71266223 |
106 | MP0003448_altered_tumor_morphology | 0.71156699 |
107 | MP0005501_abnormal_skin_physiology | 0.69632303 |
108 | MP0008873_increased_physiological_sensi | 0.68467545 |
109 | MP0001800_abnormal_humoral_immune | 0.67766514 |
110 | MP0002877_abnormal_melanocyte_morpholog | 0.67703371 |
111 | MP0002161_abnormal_fertility/fecundity | 0.67553594 |
112 | MP0002452_abnormal_antigen_presenting | 0.66958660 |
113 | MP0002111_abnormal_tail_morphology | 0.66009803 |
114 | MP0005389_reproductive_system_phenotype | 0.65371141 |
115 | MP0000647_abnormal_sebaceous_gland | 0.65256424 |
116 | MP0002420_abnormal_adaptive_immunity | 0.64529521 |
117 | MP0001819_abnormal_immune_cell | 0.63688629 |
118 | MP0002723_abnormal_immune_serum | 0.61364705 |
119 | MP0005395_other_phenotype | 0.61342766 |
120 | MP0002006_tumorigenesis | 0.60608083 |
121 | MP0003941_abnormal_skin_development | 0.60360213 |
122 | MP0002405_respiratory_system_inflammati | 0.60156739 |
123 | MP0005266_abnormal_metabolism | 0.59502932 |
124 | MP0009785_altered_susceptibility_to | 0.59445500 |
125 | MP0009053_abnormal_anal_canal | 0.58680529 |
126 | MP0003656_abnormal_erythrocyte_physiolo | 0.57941093 |
127 | MP0005000_abnormal_immune_tolerance | 0.57299429 |
128 | MP0009703_decreased_birth_body | 0.55403784 |
129 | MP0003943_abnormal_hepatobiliary_system | 0.55295887 |
130 | MP0002233_abnormal_nose_morphology | 0.55260316 |
131 | MP0006035_abnormal_mitochondrial_morpho | 0.54847447 |
132 | MP0002269_muscular_atrophy | 0.54694572 |
133 | MP0000477_abnormal_intestine_morphology | 0.53821342 |
134 | MP0002933_joint_inflammation | 0.53339539 |
135 | MP0001243_abnormal_dermal_layer | 0.52926226 |
136 | MP0000465_gastrointestinal_hemorrhage | 0.52666334 |
137 | MP0004782_abnormal_surfactant_physiolog | 0.52620473 |
138 | MP0002796_impaired_skin_barrier | 0.49651645 |
139 | MP0000627_abnormal_mammary_gland | 0.47852911 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Birth length less than 3rd percentile (HP:0003561) | 5.61333551 |
2 | Carpal bone hypoplasia (HP:0001498) | 4.31451759 |
3 | Breast hypoplasia (HP:0003187) | 4.09559747 |
4 | Irregular epiphyses (HP:0010582) | 4.07760256 |
5 | Acute necrotizing encephalopathy (HP:0006965) | 4.02001849 |
6 | Increased hepatocellular lipid droplets (HP:0006565) | 3.75679228 |
7 | Rough bone trabeculation (HP:0100670) | 3.75406524 |
8 | Acute encephalopathy (HP:0006846) | 3.66820164 |
9 | Degeneration of anterior horn cells (HP:0002398) | 3.62536561 |
10 | Abnormality of the anterior horn cell (HP:0006802) | 3.62536561 |
11 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.60563024 |
12 | Increased CSF lactate (HP:0002490) | 3.53475771 |
13 | Oral leukoplakia (HP:0002745) | 3.50649738 |
14 | Mitochondrial inheritance (HP:0001427) | 3.43531479 |
15 | Cerebral hypomyelination (HP:0006808) | 3.36516371 |
16 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.28036288 |
17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.26388485 |
18 | Reticulocytopenia (HP:0001896) | 3.25559361 |
19 | Progressive macrocephaly (HP:0004481) | 3.25165000 |
20 | Increased serum pyruvate (HP:0003542) | 3.24335453 |
21 | Patellar aplasia (HP:0006443) | 3.21707873 |
22 | Abnormal number of erythroid precursors (HP:0012131) | 3.19863673 |
23 | Aplastic anemia (HP:0001915) | 3.16517042 |
24 | Selective tooth agenesis (HP:0001592) | 3.15967410 |
25 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.05759264 |
26 | Cerebral edema (HP:0002181) | 3.02526762 |
27 | Abnormality of glycolysis (HP:0004366) | 2.99329973 |
28 | Increased serum lactate (HP:0002151) | 2.97745283 |
29 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.84346250 |
30 | Renal Fanconi syndrome (HP:0001994) | 2.84324104 |
31 | Abnormal trabecular bone morphology (HP:0100671) | 2.81531248 |
32 | Abnormality of methionine metabolism (HP:0010901) | 2.80477144 |
33 | Hepatocellular necrosis (HP:0001404) | 2.78385183 |
34 | Colon cancer (HP:0003003) | 2.78071885 |
35 | Microvesicular hepatic steatosis (HP:0001414) | 2.77019791 |
36 | Impulsivity (HP:0100710) | 2.74673390 |
37 | Small epiphyses (HP:0010585) | 2.71891179 |
38 | Abnormal lung lobation (HP:0002101) | 2.71641688 |
39 | Chromsome breakage (HP:0040012) | 2.69816943 |
40 | Abnormality of the preputium (HP:0100587) | 2.68861455 |
41 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.68568577 |
42 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.67514335 |
43 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.67514335 |
44 | Meckel diverticulum (HP:0002245) | 2.67185411 |
45 | Microretrognathia (HP:0000308) | 2.64059203 |
46 | Abnormality of chromosome stability (HP:0003220) | 2.64010273 |
47 | Multiple enchondromatosis (HP:0005701) | 2.60889140 |
48 | Hepatic necrosis (HP:0002605) | 2.60797079 |
49 | Reduced antithrombin III activity (HP:0001976) | 2.58463280 |
50 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.58151494 |
51 | Absent epiphyses (HP:0010577) | 2.58151494 |
52 | Agnosia (HP:0010524) | 2.57717752 |
53 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.56153495 |
54 | Lactic acidosis (HP:0003128) | 2.53607576 |
55 | Abnormality of the ileum (HP:0001549) | 2.52975245 |
56 | Macrocytic anemia (HP:0001972) | 2.52448067 |
57 | Trismus (HP:0000211) | 2.47061896 |
58 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.46523213 |
59 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.46048066 |
60 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.43945366 |
61 | Premature graying of hair (HP:0002216) | 2.43399594 |
62 | Flat capital femoral epiphysis (HP:0003370) | 2.38217832 |
63 | Increased intramyocellular lipid droplets (HP:0012240) | 2.36745117 |
64 | Medulloblastoma (HP:0002885) | 2.34721468 |
65 | Bone marrow hypocellularity (HP:0005528) | 2.34579510 |
66 | Exercise intolerance (HP:0003546) | 2.34576742 |
67 | Embryonal renal neoplasm (HP:0011794) | 2.34557240 |
68 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.33768507 |
69 | Absent radius (HP:0003974) | 2.33641835 |
70 | Glossoptosis (HP:0000162) | 2.33091331 |
71 | Abnormality of the pons (HP:0007361) | 2.31491962 |
72 | Entropion (HP:0000621) | 2.31435577 |
73 | Secondary amenorrhea (HP:0000869) | 2.29982850 |
74 | Abnormality of the umbilical cord (HP:0010881) | 2.29980412 |
75 | Myelodysplasia (HP:0002863) | 2.29623096 |
76 | Respiratory difficulties (HP:0002880) | 2.29372150 |
77 | Exertional dyspnea (HP:0002875) | 2.28872922 |
78 | Premature ovarian failure (HP:0008209) | 2.28346610 |
79 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.27967653 |
80 | Delayed epiphyseal ossification (HP:0002663) | 2.27133557 |
81 | Volvulus (HP:0002580) | 2.27108119 |
82 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.23429289 |
83 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.23429289 |
84 | Abnormal protein glycosylation (HP:0012346) | 2.23429289 |
85 | Abnormal glycosylation (HP:0012345) | 2.23429289 |
86 | Neoplasm of the pancreas (HP:0002894) | 2.22245098 |
87 | Absent thumb (HP:0009777) | 2.21891911 |
88 | Methylmalonic acidemia (HP:0002912) | 2.20197815 |
89 | Muscle fiber atrophy (HP:0100295) | 2.18507423 |
90 | Abnormality of the duodenum (HP:0002246) | 2.16450827 |
91 | Progressive muscle weakness (HP:0003323) | 2.15908749 |
92 | Progressive external ophthalmoplegia (HP:0000590) | 2.15139598 |
93 | Abnormality of serum amino acid levels (HP:0003112) | 2.15012126 |
94 | Pallor (HP:0000980) | 2.14048942 |
95 | Small intestinal stenosis (HP:0012848) | 2.09961558 |
96 | Duodenal stenosis (HP:0100867) | 2.09961558 |
97 | Aplasia involving forearm bones (HP:0009822) | 2.09644835 |
98 | Absent forearm bone (HP:0003953) | 2.09644835 |
99 | Thrombocytosis (HP:0001894) | 2.09590601 |
100 | Respiratory failure (HP:0002878) | 2.07752029 |
101 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.07231807 |
102 | Type 2 muscle fiber atrophy (HP:0003554) | 2.06085564 |
103 | Sparse eyelashes (HP:0000653) | 2.06074831 |
104 | Ependymoma (HP:0002888) | 2.03781681 |
105 | Spinal muscular atrophy (HP:0007269) | 2.03287277 |
106 | Abnormality of the labia minora (HP:0012880) | 2.03147495 |
107 | Stillbirth (HP:0003826) | 2.02786483 |
108 | Ureteral duplication (HP:0000073) | 2.02697429 |
109 | Leukodystrophy (HP:0002415) | 2.02628340 |
110 | Megaloblastic anemia (HP:0001889) | 2.02173329 |
111 | Cleft eyelid (HP:0000625) | 2.01910922 |
112 | CNS hypomyelination (HP:0003429) | 2.01530651 |
113 | Hypoplasia of the pons (HP:0012110) | 2.00344521 |
114 | Cellular immunodeficiency (HP:0005374) | 1.99095198 |
115 | Poor head control (HP:0002421) | 1.98379515 |
116 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.98030814 |
117 | Genu varum (HP:0002970) | 1.96183869 |
118 | Sloping forehead (HP:0000340) | 1.95118441 |
119 | Neoplasm of the colon (HP:0100273) | 1.94325131 |
120 | Rhabdomyosarcoma (HP:0002859) | 1.92186124 |
121 | 11 pairs of ribs (HP:0000878) | 1.91470329 |
122 | Horseshoe kidney (HP:0000085) | 1.91153074 |
123 | IgM deficiency (HP:0002850) | 1.89883490 |
124 | Atresia of the external auditory canal (HP:0000413) | 1.89549481 |
125 | Lymphoma (HP:0002665) | 1.89358695 |
126 | Patent foramen ovale (HP:0001655) | 1.87856982 |
127 | Abnormal spermatogenesis (HP:0008669) | 1.86593612 |
128 | Deviation of the thumb (HP:0009603) | 1.86103565 |
129 | Glioma (HP:0009733) | 1.85788213 |
130 | Type I transferrin isoform profile (HP:0003642) | 1.84937582 |
131 | Slender long bone (HP:0003100) | 1.83979728 |
132 | Optic disc pallor (HP:0000543) | 1.83576391 |
133 | Abnormality of placental membranes (HP:0011409) | 1.82848375 |
134 | Amniotic constriction ring (HP:0009775) | 1.82848375 |
135 | Postnatal microcephaly (HP:0005484) | 1.82546557 |
136 | 3-Methylglutaconic aciduria (HP:0003535) | 1.80120190 |
137 | Proximal placement of thumb (HP:0009623) | 1.79961046 |
138 | Tracheoesophageal fistula (HP:0002575) | 1.79576356 |
139 | Neoplasm of the adrenal gland (HP:0100631) | 1.79313656 |
140 | Abnormal number of incisors (HP:0011064) | 1.78669635 |
141 | Pancytopenia (HP:0001876) | 1.78490896 |
142 | Lethargy (HP:0001254) | 1.78148445 |
143 | Hyperglycinemia (HP:0002154) | 1.77966829 |
144 | Increased nuchal translucency (HP:0010880) | 1.77029438 |
145 | Squamous cell carcinoma (HP:0002860) | 1.76679150 |
146 | Abnormality of alanine metabolism (HP:0010916) | 1.76003736 |
147 | Hyperalaninemia (HP:0003348) | 1.76003736 |
148 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.76003736 |
149 | Metaphyseal cupping (HP:0003021) | 1.75782393 |
150 | Sensory axonal neuropathy (HP:0003390) | 1.75754526 |
151 | Abnormality of femoral epiphyses (HP:0006499) | 1.75573948 |
152 | Abnormality involving the epiphyses of the lower limbs (HP:0006500) | 1.75573948 |
153 | Ectopic kidney (HP:0000086) | 1.75249393 |
154 | Aseptic necrosis (HP:0010885) | 1.74847382 |
155 | Amaurosis fugax (HP:0100576) | 1.73419467 |
156 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 1.73149863 |
157 | Triphalangeal thumb (HP:0001199) | 1.72864165 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 4.98847368 |
2 | WEE1 | 4.46794533 |
3 | EIF2AK1 | 3.82153759 |
4 | BRSK2 | 3.14038108 |
5 | CDC7 | 3.06870424 |
6 | VRK2 | 2.66368500 |
7 | TSSK6 | 2.51936500 |
8 | ACVR1B | 2.49951718 |
9 | NEK2 | 2.48751102 |
10 | EIF2AK3 | 2.47658029 |
11 | SRPK1 | 2.41731866 |
12 | NME2 | 2.39671409 |
13 | PLK4 | 2.39292444 |
14 | TRIM28 | 2.15418264 |
15 | TTK | 2.15081443 |
16 | STK16 | 2.02307306 |
17 | NUAK1 | 1.99749149 |
18 | PLK1 | 1.93944883 |
19 | NEK1 | 1.87066125 |
20 | PLK3 | 1.80628513 |
21 | MKNK1 | 1.70540954 |
22 | BRSK1 | 1.65275301 |
23 | PIM2 | 1.64371591 |
24 | TESK2 | 1.55736086 |
25 | RPS6KA4 | 1.55042878 |
26 | DYRK3 | 1.54934219 |
27 | AURKB | 1.54134655 |
28 | CDK7 | 1.44588925 |
29 | VRK1 | 1.44341029 |
30 | STK10 | 1.42816496 |
31 | MKNK2 | 1.41535754 |
32 | ATR | 1.38309915 |
33 | EPHA2 | 1.36907631 |
34 | MAP3K8 | 1.35608984 |
35 | RPS6KB2 | 1.33521405 |
36 | TNIK | 1.31579051 |
37 | PASK | 1.28036786 |
38 | TAF1 | 1.24083244 |
39 | CHEK2 | 1.22816668 |
40 | CDK4 | 1.17629080 |
41 | AURKA | 1.13993346 |
42 | PBK | 1.12022911 |
43 | CHEK1 | 1.04627411 |
44 | STK3 | 1.03091541 |
45 | BMPR1B | 1.03018878 |
46 | PIM1 | 0.92855962 |
47 | MAP4K2 | 0.92008374 |
48 | TAOK2 | 0.90623103 |
49 | ERBB3 | 0.90600298 |
50 | SCYL2 | 0.90314723 |
51 | EIF2AK2 | 0.88837411 |
52 | ZAK | 0.88245242 |
53 | PNCK | 0.88244633 |
54 | TGFBR1 | 0.87976025 |
55 | MAP3K3 | 0.87492117 |
56 | CLK1 | 0.85059130 |
57 | PAK4 | 0.84936527 |
58 | STK4 | 0.83682080 |
59 | CDK12 | 0.83378372 |
60 | TESK1 | 0.82491171 |
61 | MST4 | 0.82058251 |
62 | MAP4K1 | 0.79923913 |
63 | FLT3 | 0.77426111 |
64 | CCNB1 | 0.76297260 |
65 | TLK1 | 0.74300171 |
66 | ALK | 0.73954954 |
67 | MARK3 | 0.73852672 |
68 | STK38L | 0.72252556 |
69 | MELK | 0.72089922 |
70 | CDK2 | 0.68519935 |
71 | KDR | 0.67881871 |
72 | ATM | 0.66033745 |
73 | CSNK2A2 | 0.65127513 |
74 | CSNK2A1 | 0.65037692 |
75 | MAP2K3 | 0.63880272 |
76 | BMPR2 | 0.62213969 |
77 | PAK1 | 0.62143526 |
78 | NME1 | 0.61272377 |
79 | ZAP70 | 0.60962931 |
80 | CDK8 | 0.60158363 |
81 | BCKDK | 0.58611987 |
82 | MAP3K12 | 0.56847998 |
83 | MAP3K11 | 0.56609348 |
84 | STK24 | 0.56335040 |
85 | CDK3 | 0.56011920 |
86 | CSNK1E | 0.54879991 |
87 | LRRK2 | 0.54403872 |
88 | WNK3 | 0.53570236 |
89 | PDK3 | 0.53448651 |
90 | PDK4 | 0.53448651 |
91 | DAPK1 | 0.50965344 |
92 | BRAF | 0.49837138 |
93 | CSNK1G1 | 0.48691798 |
94 | PLK2 | 0.47768061 |
95 | PRKCI | 0.47354407 |
96 | NLK | 0.46443647 |
97 | RPS6KA5 | 0.45823009 |
98 | CDK1 | 0.44789611 |
99 | IRAK3 | 0.44289098 |
100 | FGFR1 | 0.44206488 |
101 | TEC | 0.43115526 |
102 | MAP3K5 | 0.42859867 |
103 | PDK2 | 0.42596960 |
104 | IKBKB | 0.41507316 |
105 | ERBB4 | 0.38566556 |
106 | CDK9 | 0.38170966 |
107 | CSNK1G3 | 0.37428069 |
108 | CDK19 | 0.37190554 |
109 | EEF2K | 0.35907541 |
110 | CDK6 | 0.34355244 |
111 | PRKDC | 0.34347754 |
112 | STK39 | 0.34314516 |
113 | RAF1 | 0.33956052 |
114 | JAK3 | 0.33797409 |
115 | BCR | 0.32309102 |
116 | NEK9 | 0.32285850 |
117 | ABL2 | 0.31143602 |
118 | LIMK1 | 0.30535342 |
119 | TXK | 0.30315223 |
120 | BRD4 | 0.29818418 |
121 | MAPKAPK2 | 0.29299070 |
122 | PAK2 | 0.28417412 |
123 | CHUK | 0.27727805 |
124 | ILK | 0.26514152 |
125 | MAPKAPK3 | 0.26060267 |
126 | BTK | 0.25776004 |
127 | GRK1 | 0.24903366 |
128 | PIK3CG | 0.23959024 |
129 | CSNK1A1L | 0.21755884 |
130 | AKT2 | 0.21556259 |
131 | OXSR1 | 0.21338969 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 4.34863042 |
2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.07838230 |
3 | RNA polymerase_Homo sapiens_hsa03020 | 3.79081954 |
4 | Proteasome_Homo sapiens_hsa03050 | 3.70318478 |
5 | Mismatch repair_Homo sapiens_hsa03430 | 3.65090988 |
6 | RNA transport_Homo sapiens_hsa03013 | 3.22471193 |
7 | Ribosome_Homo sapiens_hsa03010 | 3.09043457 |
8 | Spliceosome_Homo sapiens_hsa03040 | 3.08837496 |
9 | Base excision repair_Homo sapiens_hsa03410 | 2.72158850 |
10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.63940524 |
11 | Homologous recombination_Homo sapiens_hsa03440 | 2.59767170 |
12 | Cell cycle_Homo sapiens_hsa04110 | 2.58078874 |
13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.50178732 |
14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.37394566 |
15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.34106620 |
16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.06829102 |
17 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.06240460 |
18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.93943324 |
19 | RNA degradation_Homo sapiens_hsa03018 | 1.84146017 |
20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.83081465 |
21 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.76864113 |
22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.65687347 |
23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.59596969 |
24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.40986298 |
25 | Purine metabolism_Homo sapiens_hsa00230 | 1.37592564 |
26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.37507126 |
27 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.36212844 |
28 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.35737772 |
29 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.26175863 |
30 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.20469182 |
31 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.15635777 |
32 | Protein export_Homo sapiens_hsa03060 | 1.09317442 |
33 | Alzheimers disease_Homo sapiens_hsa05010 | 1.02096162 |
34 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.01047321 |
35 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.99874552 |
36 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.98521007 |
37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.98459906 |
38 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.97966677 |
39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.95565615 |
40 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.94085428 |
41 | Legionellosis_Homo sapiens_hsa05134 | 0.93143295 |
42 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.88458476 |
43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.87737854 |
44 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.87704901 |
45 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.83099669 |
46 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.82297483 |
47 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.79155447 |
48 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.78913058 |
49 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.77909267 |
50 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.69634959 |
51 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.67632954 |
52 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64357353 |
53 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.61241719 |
54 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.60577762 |
55 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.59333496 |
56 | HTLV-I infection_Homo sapiens_hsa05166 | 0.58777146 |
57 | Carbon metabolism_Homo sapiens_hsa01200 | 0.58311105 |
58 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.57518190 |
59 | Sulfur relay system_Homo sapiens_hsa04122 | 0.55668281 |
60 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.54631595 |
61 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.53447749 |
62 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.51863683 |
63 | Thyroid cancer_Homo sapiens_hsa05216 | 0.51554437 |
64 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.50375408 |
65 | Measles_Homo sapiens_hsa05162 | 0.49255839 |
66 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.48477280 |
67 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.48040928 |
68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.47380095 |
69 | Apoptosis_Homo sapiens_hsa04210 | 0.46901669 |
70 | Huntingtons disease_Homo sapiens_hsa05016 | 0.46345974 |
71 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.44856778 |
72 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.44405373 |
73 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.44046316 |
74 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.41232842 |
75 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.40712209 |
76 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.40675999 |
77 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.39524604 |
78 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.39171289 |
79 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.36784241 |
80 | Influenza A_Homo sapiens_hsa05164 | 0.36779076 |
81 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.36612252 |
82 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.36578063 |
83 | Shigellosis_Homo sapiens_hsa05131 | 0.35378753 |
84 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.34784465 |
85 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.34742158 |
86 | Peroxisome_Homo sapiens_hsa04146 | 0.34596095 |
87 | Hepatitis B_Homo sapiens_hsa05161 | 0.33641765 |
88 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.33430236 |
89 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.33287436 |
90 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.32462912 |
91 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.31767576 |
92 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.31594146 |
93 | Galactose metabolism_Homo sapiens_hsa00052 | 0.30858797 |
94 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.30015269 |
95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.29342227 |
96 | Metabolic pathways_Homo sapiens_hsa01100 | 0.28820136 |
97 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.28377622 |
98 | Allograft rejection_Homo sapiens_hsa05330 | 0.27942005 |
99 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.25983720 |
100 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.25959420 |
101 | Asthma_Homo sapiens_hsa05310 | 0.25214639 |
102 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.24212549 |
103 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.21176302 |
104 | Leishmaniasis_Homo sapiens_hsa05140 | 0.20795653 |
105 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.20767498 |
106 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.20180897 |
107 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.20059078 |
108 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.20012947 |
109 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.19773832 |
110 | Lysine degradation_Homo sapiens_hsa00310 | 0.19674473 |
111 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.19486388 |
112 | Parkinsons disease_Homo sapiens_hsa05012 | 0.18946596 |
113 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.18827957 |
114 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.18618593 |
115 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.18498577 |
116 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.16908270 |
117 | Colorectal cancer_Homo sapiens_hsa05210 | 0.14394589 |
118 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.13642409 |
119 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.13469885 |
120 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.12758325 |
121 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.11457828 |
122 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.11311487 |
123 | Viral myocarditis_Homo sapiens_hsa05416 | 0.11221068 |
124 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.11200725 |
125 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.08597216 |
126 | Olfactory transduction_Homo sapiens_hsa04740 | 0.07811394 |
127 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.07346085 |
128 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.04944456 |
129 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.03980405 |
130 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.01211522 |