LUC7L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.08333329
2behavioral response to nicotine (GO:0035095)5.01408829
3nucleobase catabolic process (GO:0046113)4.79258736
4establishment of mitochondrion localization (GO:0051654)4.43742456
5mitochondrion transport along microtubule (GO:0047497)3.85497035
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.85497035
7* mRNA splice site selection (GO:0006376)3.80456005
8presynaptic membrane organization (GO:0097090)3.79431594
9head development (GO:0060322)3.57381952
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56319282
11nonmotile primary cilium assembly (GO:0035058)3.56169792
12histone H2A acetylation (GO:0043968)3.50128757
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43679546
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.43679546
15regulation of translation, ncRNA-mediated (GO:0045974)3.43679546
16somite development (GO:0061053)3.37681141
17neuron cell-cell adhesion (GO:0007158)3.33701657
18regulation of mRNA splicing, via spliceosome (GO:0048024)3.25155696
19forebrain neuron differentiation (GO:0021879)3.23405502
20neural tube formation (GO:0001841)3.20633991
21synapse assembly (GO:0007416)3.20277617
22gamma-aminobutyric acid transport (GO:0015812)3.19298837
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19018693
24neurotransmitter-gated ion channel clustering (GO:0072578)3.16334488
25retinal ganglion cell axon guidance (GO:0031290)3.11518527
26regulation of collateral sprouting (GO:0048670)3.07710671
27regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.03695522
28intraciliary transport (GO:0042073)3.03578149
29negative regulation of transcription regulatory region DNA binding (GO:2000678)3.01829517
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.00616440
31olfactory bulb development (GO:0021772)2.99369377
32tachykinin receptor signaling pathway (GO:0007217)2.99020515
33glycerophospholipid catabolic process (GO:0046475)2.97581080
34epithelial cilium movement (GO:0003351)2.97476186
35spinal cord association neuron differentiation (GO:0021527)2.97367521
36positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.95962467
37negative regulation of RNA splicing (GO:0033119)2.95086723
38dendritic spine morphogenesis (GO:0060997)2.93906859
39axoneme assembly (GO:0035082)2.93364220
40regulation of short-term neuronal synaptic plasticity (GO:0048172)2.91421236
41synaptic transmission, cholinergic (GO:0007271)2.90345195
42positive regulation of oligodendrocyte differentiation (GO:0048714)2.87633917
43short-term memory (GO:0007614)2.87326454
44microtubule depolymerization (GO:0007019)2.87028187
45vocalization behavior (GO:0071625)2.86989866
46establishment of integrated proviral latency (GO:0075713)2.86460836
47negative regulation of telomere maintenance (GO:0032205)2.86244993
48spinal cord development (GO:0021510)2.85865529
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85551431
50positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.85132738
51mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.85132738
52neuronal action potential propagation (GO:0019227)2.84268565
53calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.83225581
54spliceosomal complex assembly (GO:0000245)2.83207724
55auditory behavior (GO:0031223)2.81841343
56peptidyl-arginine omega-N-methylation (GO:0035247)2.80774748
57cell migration in hindbrain (GO:0021535)2.80192300
58protein polyglutamylation (GO:0018095)2.79722927
59neuron recognition (GO:0008038)2.79055058
60negative regulation of mRNA processing (GO:0050686)2.78957894
61cell differentiation in spinal cord (GO:0021515)2.78435854
62appendage development (GO:0048736)2.77862052
63limb development (GO:0060173)2.77862052
64hippocampus development (GO:0021766)2.76878725
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76452972
66regulation of cilium movement (GO:0003352)2.75075334
67protein localization to cilium (GO:0061512)2.74887768
68protein localization to synapse (GO:0035418)2.73789224
69regulation of mRNA processing (GO:0050684)2.71566755
70behavioral response to ethanol (GO:0048149)2.71499010
71spliceosomal tri-snRNP complex assembly (GO:0000244)2.71248323
72spliceosomal snRNP assembly (GO:0000387)2.69820887
73mechanosensory behavior (GO:0007638)2.69636050
74limb bud formation (GO:0060174)2.67695148
75negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67095822
76peptidyl-arginine methylation (GO:0018216)2.66769181
77peptidyl-arginine N-methylation (GO:0035246)2.66769181
78regulation of synapse maturation (GO:0090128)2.65749104
79regulation of microtubule-based movement (GO:0060632)2.64875897
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64652033
81regulation of synapse structural plasticity (GO:0051823)2.64031467
82regulation of development, heterochronic (GO:0040034)2.60154685
83mRNA splicing, via spliceosome (GO:0000398)2.59779132
84RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.59779132
85dendrite morphogenesis (GO:0048813)2.59595792
86cerebellar Purkinje cell differentiation (GO:0021702)2.59334556
87RNA splicing, via transesterification reactions (GO:0000375)2.58230267
88pre-miRNA processing (GO:0031054)2.58181625
89positive regulation of synapse maturation (GO:0090129)2.57850327
90axonal fasciculation (GO:0007413)2.57503864
91cilium movement (GO:0003341)2.57242980
92hindbrain development (GO:0030902)2.56196050
93neuronal ion channel clustering (GO:0045161)2.56043334
94DNA double-strand break processing (GO:0000729)2.55851363
95regulation of glutamate receptor signaling pathway (GO:1900449)2.55696192
96cilium assembly (GO:0042384)2.55190962
97histone H3-K4 trimethylation (GO:0080182)2.54641746
98synaptic transmission, glutamatergic (GO:0035249)2.54299137
99adult walking behavior (GO:0007628)2.54154221
100cilium organization (GO:0044782)2.53967196
101positive regulation of mitochondrial fission (GO:0090141)2.53882682
102positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53162984
103substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52302147
104substrate-independent telencephalic tangential migration (GO:0021826)2.52302147
105response to misfolded protein (GO:0051788)2.52055058
106regulation of RNA splicing (GO:0043484)2.51254274
107central nervous system projection neuron axonogenesis (GO:0021952)2.51091283
108DNA unwinding involved in DNA replication (GO:0006268)2.50822233
109ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50818483
110regulation of respiratory gaseous exchange (GO:0043576)2.50731829
111viral mRNA export from host cell nucleus (GO:0046784)2.48517526
112regulation of mRNA metabolic process (GO:1903311)2.47768492
113histone H2B ubiquitination (GO:0033523)2.47680971
114ionotropic glutamate receptor signaling pathway (GO:0035235)2.47443699
115startle response (GO:0001964)2.46572796
116cardiovascular system development (GO:0072358)2.46470862
117sympathetic nervous system development (GO:0048485)2.45914143
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.45463637
119postsynaptic membrane organization (GO:0001941)2.44827705
120synaptic vesicle exocytosis (GO:0016079)2.44265569
121cell proliferation in forebrain (GO:0021846)2.44132575
122neurofilament cytoskeleton organization (GO:0060052)2.42798160
123histone H4-K5 acetylation (GO:0043981)2.41659660
124histone H4-K8 acetylation (GO:0043982)2.41659660
125RNA export from nucleus (GO:0006405)2.41444827
126termination of RNA polymerase II transcription (GO:0006369)2.40468586
127positive regulation of growth hormone secretion (GO:0060124)2.40388248
128regulation of telomere maintenance (GO:0032204)2.39873569
129negative regulation of oligodendrocyte differentiation (GO:0048715)2.39567319
130layer formation in cerebral cortex (GO:0021819)2.39102459
131mRNA export from nucleus (GO:0006406)2.38958025
132intra-S DNA damage checkpoint (GO:0031573)2.37675883
133positive regulation of dendritic spine morphogenesis (GO:0061003)2.37434119
134negative regulation of microtubule polymerization (GO:0031115)2.36351705
135transmission of nerve impulse (GO:0019226)2.36258857
136histone arginine methylation (GO:0034969)2.32529176
137RNA splicing (GO:0008380)2.30772617
138neuron-neuron synaptic transmission (GO:0007270)2.29865397
139cerebellum development (GO:0021549)2.29054983
140negative regulation of histone methylation (GO:0031061)2.28932960
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.28904231
142protein-DNA complex disassembly (GO:0032986)2.28437123
143nucleosome disassembly (GO:0006337)2.28437123
144regulation of DNA damage checkpoint (GO:2000001)2.28385429
145glutamate receptor signaling pathway (GO:0007215)2.27835709
146mitotic sister chromatid cohesion (GO:0007064)2.27826842
147negative regulation of DNA recombination (GO:0045910)2.27767790
148negative regulation of mRNA metabolic process (GO:1903312)2.27321350
149kinetochore organization (GO:0051383)2.26904816
150DNA replication-dependent nucleosome organization (GO:0034723)2.26318149
151DNA replication-dependent nucleosome assembly (GO:0006335)2.26318149
152regulation of helicase activity (GO:0051095)2.24487209
153cerebral cortex radially oriented cell migration (GO:0021799)2.24087433
154DNA strand renaturation (GO:0000733)2.22192050
155presynaptic membrane assembly (GO:0097105)2.22161566
156DNA topological change (GO:0006265)2.21991696
157transcription elongation from RNA polymerase I promoter (GO:0006362)2.21785268
158DNA replication-independent nucleosome assembly (GO:0006336)2.21076373
159DNA replication-independent nucleosome organization (GO:0034724)2.21076373
160regulation of respiratory system process (GO:0044065)2.20399350
161DNA-templated transcription, termination (GO:0006353)2.20371946
162ATP-dependent chromatin remodeling (GO:0043044)2.20000633
163positive regulation of histone H3-K4 methylation (GO:0051571)2.19342738
164termination of RNA polymerase I transcription (GO:0006363)2.18712981
165alternative mRNA splicing, via spliceosome (GO:0000380)2.17511485
166kinetochore assembly (GO:0051382)2.17146755
167positive regulation of synapse assembly (GO:0051965)2.16399679
168glial cell proliferation (GO:0014009)2.16064869
169peptidyl-lysine trimethylation (GO:0018023)2.15537184
170histone H3-K9 methylation (GO:0051567)2.15418016
171regulation of histone H3-K4 methylation (GO:0051569)2.14854160
172* ribonucleoprotein complex assembly (GO:0022618)2.13163308
173histone H4 acetylation (GO:0043967)2.11257857
174neuronal stem cell maintenance (GO:0097150)2.10999212
175mRNA processing (GO:0006397)2.10310201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.61325106
2EZH2_22144423_ChIP-Seq_EOC_Human3.97046196
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79265079
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54290083
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49383867
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.41809694
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39938464
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37678647
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35230274
10IGF1R_20145208_ChIP-Seq_DFB_Human2.33675942
11* MYC_18555785_ChIP-Seq_MESCs_Mouse2.33185091
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31386302
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.23726515
14VDR_22108803_ChIP-Seq_LS180_Human2.17916201
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16586954
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.15700410
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14316788
18GBX2_23144817_ChIP-Seq_PC3_Human2.10033188
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07101448
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96317032
21CIITA_25753668_ChIP-Seq_RAJI_Human1.92504841
22FUS_26573619_Chip-Seq_HEK293_Human1.83555853
23* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82403487
24IRF1_19129219_ChIP-ChIP_H3396_Human1.79549355
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76686177
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.73901923
27DROSHA_22980978_ChIP-Seq_HELA_Human1.73307910
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73241018
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68971077
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68942087
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68141479
32ZNF274_21170338_ChIP-Seq_K562_Hela1.67541219
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65683868
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65184585
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63180906
36REST_21632747_ChIP-Seq_MESCs_Mouse1.60683669
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.60631196
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.59525500
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59274360
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57773083
41EWS_26573619_Chip-Seq_HEK293_Human1.53066281
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52626837
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49953565
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48359044
45* ETS1_20019798_ChIP-Seq_JURKAT_Human1.48330549
46TAF15_26573619_Chip-Seq_HEK293_Human1.42550227
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41595928
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40229208
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.39300832
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.37519248
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.36336057
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35779783
53* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34205498
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34083471
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33554759
56XRN2_22483619_ChIP-Seq_HELA_Human1.33083468
57TTF2_22483619_ChIP-Seq_HELA_Human1.32106730
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30820329
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28742394
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.28210317
61RNF2_27304074_Chip-Seq_NSC_Mouse1.26216419
62* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25154706
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25062502
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25036581
65* E2F1_21310950_ChIP-Seq_MCF-7_Human1.24285511
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24175233
67* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23958327
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22704788
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22043978
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21937514
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.21494109
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.21260408
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21260036
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21092916
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19717288
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18795418
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17855589
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17540699
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16848544
80ER_23166858_ChIP-Seq_MCF-7_Human1.16646699
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16078021
82VDR_23849224_ChIP-Seq_CD4+_Human1.15762907
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.15515765
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15113747
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14849264
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14628953
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13849191
88RUNX2_22187159_ChIP-Seq_PCA_Human1.13605598
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13297937
90* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12769132
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11945633
92FOXP3_21729870_ChIP-Seq_TREG_Human1.11937377
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11213510
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11213510
95SOX9_26525672_Chip-Seq_HEART_Mouse1.10557068
96WDR5_24793694_ChIP-Seq_LNCAP_Human1.10071267
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08792557
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08792557
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08334240
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.07804358
101CBP_20019798_ChIP-Seq_JUKART_Human1.07750755
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07750755
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07573525
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07476909
105STAT3_23295773_ChIP-Seq_U87_Human1.06694865
106TCF4_23295773_ChIP-Seq_U87_Human1.06590110
107SMAD4_21799915_ChIP-Seq_A2780_Human1.06572057
108* TP53_22573176_ChIP-Seq_HFKS_Human1.05961326
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05529018
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05000759
111MYC_18940864_ChIP-ChIP_HL60_Human1.04594848
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03833535
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03723492
114* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03612831
115AR_25329375_ChIP-Seq_VCAP_Human1.03504406
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03351686
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02522185
118RNF2_27304074_Chip-Seq_ESCs_Mouse1.02348961
119POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02309702
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02302557
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01326217
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99387686
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99382573
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98836176
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98823272
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98064062
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97880685
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97666532
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97624829
130SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97572422
131PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97336139
132* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97249646
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97078930
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96498789
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96323872
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95838162
137P300_19829295_ChIP-Seq_ESCs_Human0.95544121
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95382189
139AR_21572438_ChIP-Seq_LNCaP_Human0.94750549
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94728086
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.94553322
142SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94277416
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93435066
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93234174
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.93202935
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92029623
147* AR_19668381_ChIP-Seq_PC3_Human0.91491188
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90978030
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.90803522
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90345071
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90060768
152E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89824072
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87398635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.17614547
2MP0003787_abnormal_imprinting3.07104516
3MP0004859_abnormal_synaptic_plasticity2.99747515
4MP0005423_abnormal_somatic_nervous2.53809118
5MP0006292_abnormal_olfactory_placode2.53707453
6MP0003121_genomic_imprinting2.46319219
7MP0000778_abnormal_nervous_system2.32219242
8MP0003635_abnormal_synaptic_transmissio2.24361728
9MP0003122_maternal_imprinting2.15244012
10MP0001188_hyperpigmentation2.02075505
11MP0003111_abnormal_nucleus_morphology1.99491926
12MP0002063_abnormal_learning/memory/cond1.96433242
13MP0003123_paternal_imprinting1.94599391
14MP0008057_abnormal_DNA_replication1.86435441
15MP0010094_abnormal_chromosome_stability1.84970795
16MP0008058_abnormal_DNA_repair1.81988312
17MP0005646_abnormal_pituitary_gland1.77029689
18MP0002184_abnormal_innervation1.72975062
19MP0003693_abnormal_embryo_hatching1.70835075
20MP0004142_abnormal_muscle_tone1.70818719
21MP0006276_abnormal_autonomic_nervous1.69705845
22MP0005499_abnormal_olfactory_system1.68725810
23MP0005394_taste/olfaction_phenotype1.68725810
24MP0009745_abnormal_behavioral_response1.68144377
25MP0008877_abnormal_DNA_methylation1.67872884
26MP0002572_abnormal_emotion/affect_behav1.66917027
27MP0003890_abnormal_embryonic-extraembry1.65086433
28MP0008789_abnormal_olfactory_epithelium1.63590235
29MP0000631_abnormal_neuroendocrine_gland1.62981781
30MP0004270_analgesia1.62216762
31MP0001486_abnormal_startle_reflex1.62061502
32MP0001529_abnormal_vocalization1.56414200
33MP0008995_early_reproductive_senescence1.54112323
34MP0002751_abnormal_autonomic_nervous1.53675393
35MP0006072_abnormal_retinal_apoptosis1.52046227
36MP0001968_abnormal_touch/_nociception1.50008644
37MP0002557_abnormal_social/conspecific_i1.47395507
38MP0003077_abnormal_cell_cycle1.46783091
39MP0009046_muscle_twitch1.43492386
40MP0003861_abnormal_nervous_system1.43040435
41MP0002064_seizures1.42630888
42MP0000569_abnormal_digit_pigmentation1.42581061
43MP0002102_abnormal_ear_morphology1.41575766
44MP0002734_abnormal_mechanical_nocicepti1.38860381
45MP0004957_abnormal_blastocyst_morpholog1.38369485
46MP0000537_abnormal_urethra_morphology1.37940803
47MP0003938_abnormal_ear_development1.34022440
48MP0002735_abnormal_chemical_nociception1.32682273
49MP0004742_abnormal_vestibular_system1.32252486
50MP0005409_darkened_coat_color1.31305151
51MP0003136_yellow_coat_color1.30247770
52MP0008007_abnormal_cellular_replicative1.30101544
53MP0002272_abnormal_nervous_system1.29463785
54MP0000049_abnormal_middle_ear1.28847550
55MP0003119_abnormal_digestive_system1.28077434
56MP0002152_abnormal_brain_morphology1.27947013
57MP0004043_abnormal_pH_regulation1.25909645
58MP0002638_abnormal_pupillary_reflex1.24898310
59MP0001986_abnormal_taste_sensitivity1.24013481
60MP0004811_abnormal_neuron_physiology1.23990040
61MP0000955_abnormal_spinal_cord1.23460111
62MP0002067_abnormal_sensory_capabilities1.21909566
63MP0002736_abnormal_nociception_after1.20555636
64MP0002822_catalepsy1.19547476
65MP0003315_abnormal_perineum_morphology1.19410773
66MP0005645_abnormal_hypothalamus_physiol1.17119527
67MP0002882_abnormal_neuron_morphology1.16587811
68MP0001984_abnormal_olfaction1.13856478
69MP0010030_abnormal_orbit_morphology1.12720412
70MP0004133_heterotaxia1.12697577
71MP0005386_behavior/neurological_phenoty1.11921001
72MP0004924_abnormal_behavior1.11921001
73MP0008932_abnormal_embryonic_tissue1.10821724
74MP0003567_abnormal_fetal_cardiomyocyte1.06658850
75MP0003878_abnormal_ear_physiology1.05757802
76MP0005377_hearing/vestibular/ear_phenot1.05757802
77MP0002733_abnormal_thermal_nociception1.01766662
78MP0002938_white_spotting1.01656782
79MP0004885_abnormal_endolymph1.00807830
80MP0002909_abnormal_adrenal_gland0.98482346
81MP0002752_abnormal_somatic_nervous0.98288442
82MP0005391_vision/eye_phenotype0.96800762
83MP0001440_abnormal_grooming_behavior0.96681380
84MP0005195_abnormal_posterior_eye0.95048628
85MP0003937_abnormal_limbs/digits/tail_de0.94322409
86MP0001485_abnormal_pinna_reflex0.92495271
87MP0001286_abnormal_eye_development0.91961761
88MP0000015_abnormal_ear_pigmentation0.91739791
89MP0002081_perinatal_lethality0.90066251
90MP0003942_abnormal_urinary_system0.90022473
91MP0002084_abnormal_developmental_patter0.89701296
92MP0001970_abnormal_pain_threshold0.89629218
93MP0001905_abnormal_dopamine_level0.88697415
94MP0003755_abnormal_palate_morphology0.87657838
95MP0008569_lethality_at_weaning0.87072345
96MP0000566_synostosis0.86823336
97MP0005253_abnormal_eye_physiology0.86089167
98MP0005551_abnormal_eye_electrophysiolog0.86009828
99MP0001730_embryonic_growth_arrest0.85927093
100MP0002085_abnormal_embryonic_tissue0.85729761
101MP0002069_abnormal_eating/drinking_beha0.85725050
102MP0002653_abnormal_ependyma_morphology0.85268303
103MP0002928_abnormal_bile_duct0.85048610
104MP0000026_abnormal_inner_ear0.83719798
105MP0000350_abnormal_cell_proliferation0.83712328
106MP0000372_irregular_coat_pigmentation0.83237351
107MP0002066_abnormal_motor_capabilities/c0.82102685
108MP0001502_abnormal_circadian_rhythm0.81941436
109MP0003115_abnormal_respiratory_system0.81437932
110MP0001293_anophthalmia0.81160573
111MP0002234_abnormal_pharynx_morphology0.80395516
112MP0003385_abnormal_body_wall0.79528614
113MP0001501_abnormal_sleep_pattern0.79371014
114MP0001963_abnormal_hearing_physiology0.78619297
115MP0002233_abnormal_nose_morphology0.77686066
116MP0002116_abnormal_craniofacial_bone0.77573127
117MP0005167_abnormal_blood-brain_barrier0.76645818
118MP0002229_neurodegeneration0.75756772
119MP0001299_abnormal_eye_distance/0.75713002
120MP0008872_abnormal_physiological_respon0.74546544
121MP0002095_abnormal_skin_pigmentation0.65090822
122MP0003698_abnormal_male_reproductive0.64224773
123MP0010386_abnormal_urinary_bladder0.62585674

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.52186974
2Pancreatic cysts (HP:0001737)3.37395926
3True hermaphroditism (HP:0010459)3.28759194
4Nephronophthisis (HP:0000090)3.26693301
5Molar tooth sign on MRI (HP:0002419)3.25391859
6Abnormality of midbrain morphology (HP:0002418)3.25391859
7Medial flaring of the eyebrow (HP:0010747)3.21424833
8Medulloblastoma (HP:0002885)2.90866849
9Abnormality of the renal medulla (HP:0100957)2.81667285
10Colon cancer (HP:0003003)2.77390918
11Abnormality of the labia minora (HP:0012880)2.71194776
12Hyperventilation (HP:0002883)2.66080093
13Polyphagia (HP:0002591)2.61645463
14Type II lissencephaly (HP:0007260)2.61365709
15Retinal dysplasia (HP:0007973)2.57227444
16Cystic liver disease (HP:0006706)2.51600432
17Genital tract atresia (HP:0001827)2.50548300
18Occipital encephalocele (HP:0002085)2.50269834
19Vaginal atresia (HP:0000148)2.49967400
20Chronic hepatic failure (HP:0100626)2.46396929
21Poor coordination (HP:0002370)2.45224452
22Ependymoma (HP:0002888)2.41487790
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34055587
24Pachygyria (HP:0001302)2.31119975
25Focal motor seizures (HP:0011153)2.28621930
26Progressive cerebellar ataxia (HP:0002073)2.24660632
27Febrile seizures (HP:0002373)2.24602778
28Broad-based gait (HP:0002136)2.24059957
29Abnormal hair whorl (HP:0010721)2.21279738
30Nephroblastoma (Wilms tumor) (HP:0002667)2.20820062
31Anencephaly (HP:0002323)2.20593337
32Focal seizures (HP:0007359)2.20577229
33Rib fusion (HP:0000902)2.20335280
34Chromsome breakage (HP:0040012)2.19772652
35Postaxial foot polydactyly (HP:0001830)2.18301736
36Agitation (HP:0000713)2.17463534
37Epileptic encephalopathy (HP:0200134)2.16999503
38Protruding tongue (HP:0010808)2.16997223
39Sclerocornea (HP:0000647)2.14546855
40Specific learning disability (HP:0001328)2.14134966
41Abnormality of the astrocytes (HP:0100707)2.13674711
42Astrocytoma (HP:0009592)2.13674711
43Abnormal number of incisors (HP:0011064)2.12266191
44Optic nerve coloboma (HP:0000588)2.09249092
45Embryonal renal neoplasm (HP:0011794)2.08525641
46Tubulointerstitial nephritis (HP:0001970)2.02451410
47Supernumerary spleens (HP:0009799)2.01359192
48Myokymia (HP:0002411)2.00351756
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.00243187
50Drooling (HP:0002307)2.00139735
51Excessive salivation (HP:0003781)2.00139735
52Patellar aplasia (HP:0006443)1.99791021
53Glioma (HP:0009733)1.98951965
54Birth length less than 3rd percentile (HP:0003561)1.98613164
55Volvulus (HP:0002580)1.98366838
56Failure to thrive in infancy (HP:0001531)1.97297354
57Postaxial hand polydactyly (HP:0001162)1.96830396
58Cerebellar dysplasia (HP:0007033)1.95670561
59Acute lymphatic leukemia (HP:0006721)1.94449991
60Hemiparesis (HP:0001269)1.92375453
61Septo-optic dysplasia (HP:0100842)1.91206006
62Pendular nystagmus (HP:0012043)1.90720276
63Shoulder girdle muscle weakness (HP:0003547)1.90472998
64Aqueductal stenosis (HP:0002410)1.90290025
65Atonic seizures (HP:0010819)1.89953306
66Renal duplication (HP:0000075)1.88702576
67Visual hallucinations (HP:0002367)1.88305217
68Congenital hepatic fibrosis (HP:0002612)1.87414102
69Short foot (HP:0001773)1.86161624
70Abnormal lung lobation (HP:0002101)1.85756389
71Abnormality of the renal cortex (HP:0011035)1.85725108
72High anterior hairline (HP:0009890)1.85628527
73Amblyopia (HP:0000646)1.85341382
74Broad foot (HP:0001769)1.85155338
75Aplasia/Hypoplasia of the patella (HP:0006498)1.85046314
76Intestinal atresia (HP:0011100)1.84805788
77Increased nuchal translucency (HP:0010880)1.84385965
78Abnormal respiratory epithelium morphology (HP:0012253)1.83911740
79Abnormal respiratory motile cilium morphology (HP:0005938)1.83911740
80Abnormal biliary tract physiology (HP:0012439)1.82978281
81Bile duct proliferation (HP:0001408)1.82978281
82Anophthalmia (HP:0000528)1.82667386
83Gastroesophageal reflux (HP:0002020)1.82446013
84Congenital stationary night blindness (HP:0007642)1.82385620
85Gait imbalance (HP:0002141)1.80229181
86Broad alveolar ridges (HP:0000187)1.80053419
87Dandy-Walker malformation (HP:0001305)1.79676352
88Hypoplastic iliac wings (HP:0002866)1.79384406
89Abnormality of the aortic arch (HP:0012303)1.78806054
90Meckel diverticulum (HP:0002245)1.78103585
91Hip dysplasia (HP:0001385)1.77828951
92Trigonocephaly (HP:0000243)1.77621543
93Lissencephaly (HP:0001339)1.76624129
94Aganglionic megacolon (HP:0002251)1.76618076
95Gaze-evoked nystagmus (HP:0000640)1.75164658
96Abnormality of the ileum (HP:0001549)1.74659005
97Embryonal neoplasm (HP:0002898)1.74222573
98Macroglossia (HP:0000158)1.73891372
99Short 4th metacarpal (HP:0010044)1.73726671
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73726671
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.72831645
102Partial agenesis of the corpus callosum (HP:0001338)1.72202530
103Pointed chin (HP:0000307)1.70128688
104Status epilepticus (HP:0002133)1.70012054
105Esophageal atresia (HP:0002032)1.69776984
106Exotropia (HP:0000577)1.69102618
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68859700
108Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68500881
109Abnormality of the antihelix (HP:0009738)1.68297751
110Renal hypoplasia (HP:0000089)1.68120000
111Inability to walk (HP:0002540)1.67933000
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.67848387
113Hypoplasia of the brainstem (HP:0002365)1.67786769
114Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67786769
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.65992467
116Bilateral microphthalmos (HP:0007633)1.65659229
117Dialeptic seizures (HP:0011146)1.65448447
118Limb dystonia (HP:0002451)1.65273370
119Impaired vibration sensation in the lower limbs (HP:0002166)1.65185283
120Obsessive-compulsive behavior (HP:0000722)1.63258686
121Abnormality of the intervertebral disk (HP:0005108)1.63082592
122Renal dysplasia (HP:0000110)1.62584821
123Autism (HP:0000717)1.62295339
124Amyotrophic lateral sclerosis (HP:0007354)1.62250513
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.61023981
126Retinitis pigmentosa (HP:0000510)1.60572306
127Absent speech (HP:0001344)1.60135893
128Abnormal eating behavior (HP:0100738)1.60016488
129Impaired smooth pursuit (HP:0007772)1.59832438
130Preaxial hand polydactyly (HP:0001177)1.59574343
131Inappropriate behavior (HP:0000719)1.59097668
132Prominent nasal bridge (HP:0000426)1.58975763
133Genetic anticipation (HP:0003743)1.58938556
134Abnormality of chromosome stability (HP:0003220)1.58668436
135Abnormality of the preputium (HP:0100587)1.57730681
136Insomnia (HP:0100785)1.57534619
137Hyperacusis (HP:0010780)1.57063801
138Facial hemangioma (HP:0000329)1.57028529
139Abnormality of the carotid arteries (HP:0005344)1.56779600
140Horseshoe kidney (HP:0000085)1.55803427
141Sacral dimple (HP:0000960)1.55760669
142Optic nerve hypoplasia (HP:0000609)1.55280707
143Gastrointestinal atresia (HP:0002589)1.55141167
144Ankle clonus (HP:0011448)1.53736617
145Micropenis (HP:0000054)1.53491434
146Anal stenosis (HP:0002025)1.52878336
147Proximal placement of thumb (HP:0009623)1.52427284
148Nephrogenic diabetes insipidus (HP:0009806)1.52169142
149Abnormality of chromosome segregation (HP:0002916)1.50540308
150Neoplasm of the adrenal cortex (HP:0100641)1.50276315
151Neoplasm of the oral cavity (HP:0100649)1.50012251
152Overriding aorta (HP:0002623)1.49667087
153Congenital primary aphakia (HP:0007707)1.48591355
154Severe visual impairment (HP:0001141)1.48255752
155Abnormality of the incisor (HP:0000676)1.48219440
156Narrow forehead (HP:0000341)1.47822741
157Hepatoblastoma (HP:0002884)1.47724510
158Heterotopia (HP:0002282)1.46289393
159Oligodactyly (hands) (HP:0001180)1.46185106
160Anteriorly placed anus (HP:0001545)1.45095799
161Abnormality of the metopic suture (HP:0005556)1.44728474
162Cerebral hypomyelination (HP:0006808)1.44714384
163Duodenal stenosis (HP:0100867)1.44408462
164Small intestinal stenosis (HP:0012848)1.44408462
165Renovascular hypertension (HP:0100817)1.43625589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.80593199
2MAPK133.12863831
3SRPK12.96108459
4NTRK32.90704724
5CASK2.61140298
6PNCK2.51864307
7MAP3K42.47269807
8MKNK12.40970084
9MKNK22.38043065
10PINK12.28705415
11TSSK62.22208293
12CDC72.19824775
13MAP4K22.19822482
14BUB12.12852943
15FRK2.11878795
16EPHA42.11757049
17MAP2K72.10412316
18NTRK21.95898972
19PLK31.94547389
20SIK21.92447743
21VRK11.84798587
22UHMK11.77717092
23ERBB31.77521014
24EEF2K1.69411261
25WEE11.68123345
26ADRBK21.63303546
27TNIK1.59996784
28CDK191.56669212
29MINK11.48337566
30DYRK21.47497039
31BMPR1B1.47447454
32BRD41.39827459
33PAK31.37081860
34CDK81.33219590
35EPHA31.32652897
36TAOK31.30916902
37MAPK151.30204212
38KSR11.25568318
39PRPF4B1.24376058
40PASK1.21214100
41AKT31.20270615
42BCKDK1.17508890
43STK161.14822417
44ATR1.13900716
45DYRK31.10595725
46CDK31.10237458
47DYRK1A1.10114571
48CAMK1G1.09923662
49CAMK1D1.08412082
50DYRK1B1.07078783
51YES11.06606236
52CHEK21.05034192
53FGFR21.01139625
54DAPK11.00680061
55CSNK1G31.00252165
56CSNK1G20.98431699
57PLK20.98277740
58ZAK0.97010285
59CAMKK20.92736002
60MAP3K90.91776546
61CAMK10.91152626
62SIK30.90958383
63CHEK10.90855963
64CAMKK10.90458426
65INSRR0.89363475
66SGK20.89249986
67MARK20.88658553
68NUAK10.88553565
69CSNK1A1L0.82358702
70WNK30.82304935
71STK110.81206211
72GRK10.79704542
73CDK50.78931410
74PLK10.78795148
75SGK4940.77188597
76SGK2230.77188597
77BCR0.76553138
78CDK10.75174867
79PRKD30.74774505
80PIK3CA0.74619373
81RPS6KA20.74418020
82CDK20.74170878
83PKN10.74104343
84RPS6KB10.73935818
85CSNK1E0.73506346
86TAOK20.73127066
87PRKCG0.72624193
88ATM0.70992375
89CAMK40.70332060
90CDK70.69927396
91RPS6KB20.68975973
92GRK70.66150392
93PRKCZ0.66058172
94MAP2K40.64752090
95AURKA0.64744634
96CDK180.64599036
97TLK10.64309515
98BRSK10.63493419
99RPS6KA40.63455627
100WNK40.63195081
101NEK20.63058815
102PRKCI0.62416814
103ERBB20.60889575
104CDK11A0.60653364
105MAP3K70.60520410
106FES0.59753290
107GSK3B0.58934662
108EIF2AK20.58101619
109CDK150.58021023
110CSNK1G10.57447545
111TGFBR10.56921767
112OXSR10.56261240
113PAK60.56009599
114PDK20.54979196
115TIE10.53853087
116MAPK90.53379081
117PRKCH0.52950393
118CCNB10.52447502
119PRKAA10.52321165
120DAPK20.50590442
121TEC0.49954469
122NEK60.49371153
123RPS6KA50.49361906
124MAPK140.49169677
125GRK50.48909901
126TTK0.48859282
127PRKDC0.48260478
128CSNK1A10.48239229
129CSNK1D0.47719850
130CDK140.47203263
131MAPK100.46705519
132MAPK80.46538865
133ALK0.46157417
134CAMK2A0.45628266
135TYRO30.45580141
136MAP3K60.45562020
137CSNK2A20.45293075
138CDK120.44846246
139ITK0.44688631
140RPS6KA60.43926039
141TNK20.43718040
142SGK10.42472912
143EIF2AK10.41693637
144FLT30.41322279
145PRKCE0.41320805
146AURKB0.40610274
147PRKACA0.40023136
148CHUK0.39542764
149NLK0.35402990
150AKT10.34628786
151EPHB20.31647272

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030402.95700887
2Nicotine addiction_Homo sapiens_hsa050332.85042853
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.60037662
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57744269
5Mismatch repair_Homo sapiens_hsa034302.39812994
6Linoleic acid metabolism_Homo sapiens_hsa005912.36672109
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23171874
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13185415
9RNA transport_Homo sapiens_hsa030132.12039419
10Ether lipid metabolism_Homo sapiens_hsa005652.04593968
11mRNA surveillance pathway_Homo sapiens_hsa030152.01891088
12RNA polymerase_Homo sapiens_hsa030201.98043889
13DNA replication_Homo sapiens_hsa030301.97652832
14Fanconi anemia pathway_Homo sapiens_hsa034601.84694948
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79912419
16Circadian entrainment_Homo sapiens_hsa047131.76123012
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73533486
18Glutamatergic synapse_Homo sapiens_hsa047241.71899484
19Morphine addiction_Homo sapiens_hsa050321.70222422
20GABAergic synapse_Homo sapiens_hsa047271.65705846
21Dopaminergic synapse_Homo sapiens_hsa047281.65646889
22Non-homologous end-joining_Homo sapiens_hsa034501.63398630
23Amphetamine addiction_Homo sapiens_hsa050311.63066867
24RNA degradation_Homo sapiens_hsa030181.60770341
25Olfactory transduction_Homo sapiens_hsa047401.60169891
26Nucleotide excision repair_Homo sapiens_hsa034201.59156637
27Long-term potentiation_Homo sapiens_hsa047201.58394963
28Regulation of autophagy_Homo sapiens_hsa041401.57731579
29Cell cycle_Homo sapiens_hsa041101.55525532
30Synaptic vesicle cycle_Homo sapiens_hsa047211.54205362
31Butanoate metabolism_Homo sapiens_hsa006501.52168555
32Base excision repair_Homo sapiens_hsa034101.49812345
33Phototransduction_Homo sapiens_hsa047441.49804090
34Basal transcription factors_Homo sapiens_hsa030221.46868729
35Taste transduction_Homo sapiens_hsa047421.44491609
36Oocyte meiosis_Homo sapiens_hsa041141.42027220
37Homologous recombination_Homo sapiens_hsa034401.41883118
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38559357
39Cardiac muscle contraction_Homo sapiens_hsa042601.37170730
40Oxidative phosphorylation_Homo sapiens_hsa001901.34850995
41Steroid biosynthesis_Homo sapiens_hsa001001.33595218
42Cocaine addiction_Homo sapiens_hsa050301.30907686
43Alcoholism_Homo sapiens_hsa050341.30595590
44Parkinsons disease_Homo sapiens_hsa050121.28396619
45Serotonergic synapse_Homo sapiens_hsa047261.26754808
46Axon guidance_Homo sapiens_hsa043601.26753749
47Selenocompound metabolism_Homo sapiens_hsa004501.23337140
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20308690
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18989261
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18682910
51Cholinergic synapse_Homo sapiens_hsa047251.17749615
52Ribosome_Homo sapiens_hsa030101.14257829
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09223818
54Insulin secretion_Homo sapiens_hsa049111.09216641
55Long-term depression_Homo sapiens_hsa047301.06574327
56Pyrimidine metabolism_Homo sapiens_hsa002401.06308151
57Protein export_Homo sapiens_hsa030601.02503929
58Wnt signaling pathway_Homo sapiens_hsa043100.99450755
59Huntingtons disease_Homo sapiens_hsa050160.99328991
60Colorectal cancer_Homo sapiens_hsa052100.98613239
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98123594
62Ovarian steroidogenesis_Homo sapiens_hsa049130.96121321
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96010751
64Purine metabolism_Homo sapiens_hsa002300.93468960
65Basal cell carcinoma_Homo sapiens_hsa052170.92706266
66ErbB signaling pathway_Homo sapiens_hsa040120.92553647
67Gap junction_Homo sapiens_hsa045400.92180247
68Proteasome_Homo sapiens_hsa030500.90046053
69Oxytocin signaling pathway_Homo sapiens_hsa049210.88838664
70Melanogenesis_Homo sapiens_hsa049160.87726802
71Calcium signaling pathway_Homo sapiens_hsa040200.86816300
72Hedgehog signaling pathway_Homo sapiens_hsa043400.86030914
73Salivary secretion_Homo sapiens_hsa049700.84105531
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83847972
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81018207
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.79883497
77Endometrial cancer_Homo sapiens_hsa052130.79403357
78Estrogen signaling pathway_Homo sapiens_hsa049150.76234958
79Glioma_Homo sapiens_hsa052140.75224040
80Renin secretion_Homo sapiens_hsa049240.74296091
81ABC transporters_Homo sapiens_hsa020100.73296636
82GnRH signaling pathway_Homo sapiens_hsa049120.71979758
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71976938
84Gastric acid secretion_Homo sapiens_hsa049710.68262706
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68017917
86Epstein-Barr virus infection_Homo sapiens_hsa051690.67209504
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66902221
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65945078
89Glycerolipid metabolism_Homo sapiens_hsa005610.64628731
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64272095
91Hippo signaling pathway_Homo sapiens_hsa043900.63538922
92Collecting duct acid secretion_Homo sapiens_hsa049660.62595336
93One carbon pool by folate_Homo sapiens_hsa006700.62553256
94Non-small cell lung cancer_Homo sapiens_hsa052230.61035716
95cAMP signaling pathway_Homo sapiens_hsa040240.60308040
96Propanoate metabolism_Homo sapiens_hsa006400.59542361
97Notch signaling pathway_Homo sapiens_hsa043300.59422681
98MicroRNAs in cancer_Homo sapiens_hsa052060.59104140
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58996057
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58899945
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57892464
102Dorso-ventral axis formation_Homo sapiens_hsa043200.57884747
103Systemic lupus erythematosus_Homo sapiens_hsa053220.57856187
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57363199
105Nitrogen metabolism_Homo sapiens_hsa009100.56727665
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.56698040
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54289907
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54269219
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53797567
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53258266
111MAPK signaling pathway_Homo sapiens_hsa040100.52504296
112Peroxisome_Homo sapiens_hsa041460.50812932
113mTOR signaling pathway_Homo sapiens_hsa041500.50508293
114HTLV-I infection_Homo sapiens_hsa051660.49580266
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.49139889
116Type II diabetes mellitus_Homo sapiens_hsa049300.48873269
117Alzheimers disease_Homo sapiens_hsa050100.48741058
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.47643202
119N-Glycan biosynthesis_Homo sapiens_hsa005100.46578880
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45034606
121Circadian rhythm_Homo sapiens_hsa047100.44978174
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.43328118
123Arachidonic acid metabolism_Homo sapiens_hsa005900.42572383
124Pathways in cancer_Homo sapiens_hsa052000.41685901
125Viral carcinogenesis_Homo sapiens_hsa052030.40864237
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40144254
127Tryptophan metabolism_Homo sapiens_hsa003800.39724575
128Renal cell carcinoma_Homo sapiens_hsa052110.39691015
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38758211
130Choline metabolism in cancer_Homo sapiens_hsa052310.38194067
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38179498
132Melanoma_Homo sapiens_hsa052180.36636835
133Lysine degradation_Homo sapiens_hsa003100.36406173
134Vibrio cholerae infection_Homo sapiens_hsa051100.34988277
135Prostate cancer_Homo sapiens_hsa052150.34296118
136Rap1 signaling pathway_Homo sapiens_hsa040150.34256187
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33711540
138Ras signaling pathway_Homo sapiens_hsa040140.33349270
139Sulfur relay system_Homo sapiens_hsa041220.25743985

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