LUC7L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)6.01231547
2nuclear pore complex assembly (GO:0051292)5.37802846
3negative regulation of histone methylation (GO:0031061)4.89708203
4viral transcription (GO:0019083)4.78753818
5DNA topological change (GO:0006265)4.77506857
6translational termination (GO:0006415)4.72261911
7nuclear pore organization (GO:0006999)4.61797677
8regulation of RNA export from nucleus (GO:0046831)4.53155365
9mitotic chromosome condensation (GO:0007076)4.50493522
10alternative mRNA splicing, via spliceosome (GO:0000380)4.49407007
11DNA unwinding involved in DNA replication (GO:0006268)4.27317665
12regulation of histone H3-K4 methylation (GO:0051569)4.27175484
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.19975711
14ribosomal small subunit biogenesis (GO:0042274)4.15118972
15regulation of histone H3-K9 methylation (GO:0051570)4.10817278
16maturation of SSU-rRNA (GO:0030490)4.10370112
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.03874930
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.00674572
19negative regulation of translation, ncRNA-mediated (GO:0040033)4.00674572
20regulation of translation, ncRNA-mediated (GO:0045974)4.00674572
21peptidyl-lysine trimethylation (GO:0018023)3.93840883
22histone H3-K4 methylation (GO:0051568)3.93300019
23cellular protein complex disassembly (GO:0043624)3.80611080
24cytoplasmic mRNA processing body assembly (GO:0033962)3.78004148
25negative regulation of RNA splicing (GO:0033119)3.76726780
26meiotic chromosome segregation (GO:0045132)3.74486407
27pore complex assembly (GO:0046931)3.69479858
28negative regulation of mRNA processing (GO:0050686)3.69319515
29sister chromatid segregation (GO:0000819)3.65434886
30translational elongation (GO:0006414)3.65306462
31histone H3-K36 demethylation (GO:0070544)3.63377975
32regulation of histone methylation (GO:0031060)3.63239411
33viral life cycle (GO:0019058)3.62956691
34DNA replication checkpoint (GO:0000076)3.62856857
35protein complex disassembly (GO:0043241)3.61521819
36regulation of chromatin binding (GO:0035561)3.60830493
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56410734
38translational initiation (GO:0006413)3.54915829
39cotranslational protein targeting to membrane (GO:0006613)3.54853347
40protein targeting to ER (GO:0045047)3.54690804
41kinetochore organization (GO:0051383)3.51501341
42mitotic sister chromatid segregation (GO:0000070)3.48391055
43macromolecular complex disassembly (GO:0032984)3.48050948
44regulation of centriole replication (GO:0046599)3.47145308
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47030826
46positive regulation of histone H3-K4 methylation (GO:0051571)3.44942334
47centriole replication (GO:0007099)3.42865966
48histone H2B ubiquitination (GO:0033523)3.42046775
49regulation of nucleobase-containing compound transport (GO:0032239)3.41512322
50mRNA splicing, via spliceosome (GO:0000398)3.40689147
51RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.40689147
52RNA splicing, via transesterification reactions (GO:0000375)3.37901461
53microtubule depolymerization (GO:0007019)3.37282954
54positive regulation of response to oxidative stress (GO:1902884)3.36463658
55positive regulation of cellular response to oxidative stress (GO:1900409)3.36463658
56ribosomal small subunit assembly (GO:0000028)3.35960407
57DNA strand elongation involved in DNA replication (GO:0006271)3.26241997
58protein localization to endoplasmic reticulum (GO:0070972)3.21521969
59negative regulation of mRNA metabolic process (GO:1903312)3.20549430
60regulation of histone H3-K27 methylation (GO:0061085)3.18140024
61histone lysine methylation (GO:0034968)3.14956656
62DNA strand elongation (GO:0022616)3.11587485
63regulation of DNA endoreduplication (GO:0032875)3.10412736
64ribosomal large subunit biogenesis (GO:0042273)3.09360374
65DNA replication initiation (GO:0006270)3.09075019
66positive regulation of histone methylation (GO:0031062)3.08010876
67positive T cell selection (GO:0043368)3.07815265
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07798309
69regulation of centrosome cycle (GO:0046605)3.06656382
70spermatid nucleus differentiation (GO:0007289)3.04343015
71insulin-like growth factor receptor signaling pathway (GO:0048009)3.00332085
72chromosome condensation (GO:0030261)3.00215962
73CENP-A containing nucleosome assembly (GO:0034080)2.99586141
74mitotic sister chromatid cohesion (GO:0007064)2.98071701
75V(D)J recombination (GO:0033151)2.96939860
76dosage compensation (GO:0007549)2.96526927
77cerebellar Purkinje cell differentiation (GO:0021702)2.96428281
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96063603
79negative regulation of cell killing (GO:0031342)2.96063603
80ionotropic glutamate receptor signaling pathway (GO:0035235)2.95227959
81regulation of centrosome duplication (GO:0010824)2.94211304
82nuclear-transcribed mRNA catabolic process (GO:0000956)2.93592971
83* mRNA splice site selection (GO:0006376)2.93126927
84chromatin remodeling at centromere (GO:0031055)2.91334965
85mitotic nuclear envelope disassembly (GO:0007077)2.89902559
86DNA conformation change (GO:0071103)2.88493231
87monoubiquitinated protein deubiquitination (GO:0035520)2.87770427
88centriole assembly (GO:0098534)2.87655841
89DNA synthesis involved in DNA repair (GO:0000731)2.86305320
90DNA duplex unwinding (GO:0032508)2.85732289
91termination of RNA polymerase II transcription (GO:0006369)2.85329912
92glucocorticoid receptor signaling pathway (GO:0042921)2.83938711
93DNA replication-independent nucleosome assembly (GO:0006336)2.83929458
94DNA replication-independent nucleosome organization (GO:0034724)2.83929458
95ribonucleoprotein complex biogenesis (GO:0022613)2.83523661
96peptidyl-lysine methylation (GO:0018022)2.83428627
97mRNA catabolic process (GO:0006402)2.82733998
98membrane disassembly (GO:0030397)2.82479018
99nuclear envelope disassembly (GO:0051081)2.82479018
100positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.82373596
101regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.82373596
102RNA splicing (GO:0008380)2.80623281
103sister chromatid cohesion (GO:0007062)2.80543186
104positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.79313743
105regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.79313743
106RNA stabilization (GO:0043489)2.78735862
107mRNA stabilization (GO:0048255)2.78735862
108DNA packaging (GO:0006323)2.77294069
109ATP-dependent chromatin remodeling (GO:0043044)2.77287699
110DNA geometric change (GO:0032392)2.76920364
111positive regulation of RNA splicing (GO:0033120)2.76680285
112mRNA export from nucleus (GO:0006406)2.76318121
113interkinetic nuclear migration (GO:0022027)2.76212819
114protein localization to chromosome, centromeric region (GO:0071459)2.73078141
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69619916
116retrograde transport, vesicle recycling within Golgi (GO:0000301)2.69533459
117histone H3-K9 modification (GO:0061647)2.68099686
118positive thymic T cell selection (GO:0045059)2.66048142
119positive regulation of histone deacetylation (GO:0031065)2.62194728
120histone H3-K9 demethylation (GO:0033169)2.55028785
121establishment of protein localization to Golgi (GO:0072600)2.54799295
122histone H3-K9 methylation (GO:0051567)2.46845053
123protein targeting to Golgi (GO:0000042)2.44633560
124embryonic camera-type eye morphogenesis (GO:0048596)2.44271666
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.43231477
126Golgi to endosome transport (GO:0006895)2.43110481
127positive regulation of CREB transcription factor activity (GO:0032793)2.42448567
128I-kappaB phosphorylation (GO:0007252)2.39012496
129positive regulation of gamma-delta T cell activation (GO:0046645)2.37918267
130positive regulation of mRNA catabolic process (GO:0061014)2.33625124
131stress granule assembly (GO:0034063)2.32920125
132histone methylation (GO:0016571)2.31082846
133B cell homeostasis (GO:0001782)2.29694657
134histone lysine demethylation (GO:0070076)2.26757351
135regulation of histone deacetylation (GO:0031063)2.26171718
136glutamate receptor signaling pathway (GO:0007215)2.25052383
137nucleus localization (GO:0051647)2.24886736
138histone demethylation (GO:0016577)2.24519632
139nerve growth factor signaling pathway (GO:0038180)2.23956508
140regulation of mRNA catabolic process (GO:0061013)2.23943168
141regulation of protein polyubiquitination (GO:1902914)2.23670309
142germinal center formation (GO:0002467)2.23264511
143positive regulation of granulocyte differentiation (GO:0030854)2.22227110
144prostate gland growth (GO:0060736)2.21994476
145early endosome to late endosome transport (GO:0045022)2.21992392
146positive regulation of cardiac muscle cell differentiation (GO:2000727)2.19389678
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.18755528
148cAMP catabolic process (GO:0006198)2.17101223
149definitive hemopoiesis (GO:0060216)2.16752671
150T cell selection (GO:0045058)2.14838442
151cyclic nucleotide catabolic process (GO:0009214)2.12877736
152presynaptic membrane assembly (GO:0097105)2.12477999
153regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.11435035
154synaptic transmission, glutamatergic (GO:0035249)2.08857473
155relaxation of cardiac muscle (GO:0055119)2.08210782
156import into cell (GO:0098657)2.07473876
157negative T cell selection (GO:0043383)2.06237979
158histone H4-K16 acetylation (GO:0043984)2.06158015
159megakaryocyte development (GO:0035855)2.04367903
160central nervous system projection neuron axonogenesis (GO:0021952)2.04029397
161positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.03838558
162CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.03795095
163regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.02345069
164activated T cell proliferation (GO:0050798)2.00645230
165chondrocyte development (GO:0002063)2.00326007
166growth hormone receptor signaling pathway (GO:0060396)2.00014529
167peptidyl-threonine phosphorylation (GO:0018107)1.99336740
168genitalia morphogenesis (GO:0035112)1.98466354
169phosphatidylinositol phosphorylation (GO:0046854)1.97013608
170regulation of Rac protein signal transduction (GO:0035020)1.96830060
171phospholipid translocation (GO:0045332)1.94704754
172lipid translocation (GO:0034204)1.94704754
173poly(A)+ mRNA export from nucleus (GO:0016973)1.94572612
174phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.94185237
175regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.93025498
176interferon-gamma production (GO:0032609)1.92571771
177heart morphogenesis (GO:0003007)1.92044976
178negative thymic T cell selection (GO:0045060)1.90976362
179coronary vasculature morphogenesis (GO:0060977)1.90398927
180establishment of nucleus localization (GO:0040023)1.89967113
181phosphatidylinositol dephosphorylation (GO:0046856)1.89829442
182regulation of B cell receptor signaling pathway (GO:0050855)1.89821353
183thymic T cell selection (GO:0045061)1.89492757
184developmental pigmentation (GO:0048066)1.89401471
185embryonic viscerocranium morphogenesis (GO:0048703)1.89237429
186positive regulation of cation channel activity (GO:2001259)1.88548831
187gamma-aminobutyric acid transport (GO:0015812)1.88153318
188regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.88099259
189peptidyl-threonine modification (GO:0018210)1.86007913
190positive regulation of mRNA processing (GO:0050685)1.85848400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.98310346
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55890927
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.33446207
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11864306
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.09917274
6EZH2_22144423_ChIP-Seq_EOC_Human2.99430986
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.97054909
8GBX2_23144817_ChIP-Seq_PC3_Human2.86669708
9* E2F1_21310950_ChIP-Seq_MCF-7_Human2.80775948
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76076071
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.70022669
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53275212
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45228125
14* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44132240
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41354832
16* MYC_22102868_ChIP-Seq_BL_Human2.41012726
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35709189
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30577337
19* XRN2_22483619_ChIP-Seq_HELA_Human2.27505894
20AR_21909140_ChIP-Seq_LNCAP_Human2.25409447
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.20361339
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.19749333
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17339550
24* TTF2_22483619_ChIP-Seq_HELA_Human2.16546726
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13010235
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06271768
27E2F7_22180533_ChIP-Seq_HELA_Human10.5842886
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96197331
29TP53_16413492_ChIP-PET_HCT116_Human1.88785365
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88095256
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87421725
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84309688
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79841892
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78831824
35DROSHA_22980978_ChIP-Seq_HELA_Human1.78372479
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77978064
37ELK1_19687146_ChIP-ChIP_HELA_Human1.76428417
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70494955
39* KDM5A_27292631_Chip-Seq_BREAST_Human1.66294583
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65958060
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63191590
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61006486
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.60817314
44CIITA_25753668_ChIP-Seq_RAJI_Human1.60744268
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59002396
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58435814
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57073953
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54250637
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53966838
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53935685
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.53684789
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.51337202
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.50615695
54TAF15_26573619_Chip-Seq_HEK293_Human1.50552341
55RUNX_20019798_ChIP-Seq_JUKART_Human1.50114789
56* STAT3_23295773_ChIP-Seq_U87_Human1.49383168
57AHR_22903824_ChIP-Seq_MCF-7_Human1.48783953
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48576263
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47447165
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47173159
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47130558
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47036872
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46588547
64* VDR_23849224_ChIP-Seq_CD4+_Human1.45912712
65GATA1_22025678_ChIP-Seq_K562_Human1.45213969
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44459881
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44114537
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.43739358
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.40891177
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.39611506
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.39541284
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38950484
73TCF4_23295773_ChIP-Seq_U87_Human1.38087506
74AR_21572438_ChIP-Seq_LNCaP_Human1.38019092
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37989629
76FUS_26573619_Chip-Seq_HEK293_Human1.37283395
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36730369
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35415978
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35398883
80P300_19829295_ChIP-Seq_ESCs_Human1.34430773
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.34177614
82MYC_18940864_ChIP-ChIP_HL60_Human1.32284763
83DCP1A_22483619_ChIP-Seq_HELA_Human1.32130736
84* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.31240434
85KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29745498
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29097498
87* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28789860
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27214788
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25519803
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25240215
91CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24220383
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24061753
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23300499
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.22451975
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22397688
96* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21707615
97EWS_26573619_Chip-Seq_HEK293_Human1.21496336
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.21385630
99P53_22387025_ChIP-Seq_ESCs_Mouse1.20539241
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20443786
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20443786
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20443786
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20104402
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20104402
105CHD1_26751641_Chip-Seq_LNCaP_Human1.18451630
106NCOR1_26117541_ChIP-Seq_K562_Human1.18023528
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17876698
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17151217
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16856040
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.16725796
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16265395
112SCL_19346495_ChIP-Seq_HPC-7_Human1.15735120
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15516004
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14515078
115FOXP3_21729870_ChIP-Seq_TREG_Human1.14096532
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.13628091
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13040361
118* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12765631
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12680169
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12618999
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12613738
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12207088
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11891524
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.11872050
125SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11711909
126* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11688609
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11685466
128PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11228923
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10853734
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10714105
131GABP_17652178_ChIP-ChIP_JURKAT_Human1.10377228
132RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10114588
133EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10114588
134FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09603299
135RUNX2_22187159_ChIP-Seq_PCA_Human1.08879511
136WT1_19549856_ChIP-ChIP_CCG9911_Human1.08876789
137YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08141477
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07387202
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07211283
140P300_18555785_Chip-Seq_ESCs_Mouse1.06284014
141EED_16625203_ChIP-ChIP_MESCs_Mouse1.05900783
142RXR_22108803_ChIP-Seq_LS180_Human1.05040283
143* TP53_18474530_ChIP-ChIP_U2OS_Human1.04565929
144ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04535344
145* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04365158
146ER_23166858_ChIP-Seq_MCF-7_Human1.03744056
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02935697
148GATA1_19941826_ChIP-Seq_K562_Human1.02694939
149TBL1_22424771_ChIP-Seq_293T_Human1.02411311
150* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02238558
151VDR_24787735_ChIP-Seq_THP-1_Human1.02223153
152* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01809041
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01592064
154AR_19668381_ChIP-Seq_PC3_Human1.01216531
155RNF2_27304074_Chip-Seq_NSC_Mouse1.01024892
156MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00298012
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00019648
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.99622573
159GATA2_21666600_ChIP-Seq_HMVEC_Human0.99159852
160* AR_25329375_ChIP-Seq_VCAP_Human0.98442253
161STAT3_18555785_Chip-Seq_ESCs_Mouse0.97095725
162SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96655929
163TCF4_18268006_ChIP-ChIP_LS174T_Human0.96608732
164ISL1_27105846_Chip-Seq_CPCs_Mouse0.96370041
165RARB_27405468_Chip-Seq_BRAIN_Mouse0.96180353
166CBX2_27304074_Chip-Seq_ESCs_Mouse0.93913817
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.91123689
168HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90773982
169* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90482180
170SOX2_16153702_ChIP-ChIP_HESCs_Human0.90219195
171CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88496634
172RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87200183
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86855203
174SOX9_26525672_Chip-Seq_HEART_Mouse0.86686290
175KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82973465
176E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81826491
177* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80624825
178TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79716293
179SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79255956
180ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77917468
181GABP_19822575_ChIP-Seq_HepG2_Human0.77720419
182HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76937725
183ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74475261
184VDR_22108803_ChIP-Seq_LS180_Human0.74002224
185ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71549373
186JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.69714154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.73116221
2MP0003787_abnormal_imprinting4.02675899
3MP0010094_abnormal_chromosome_stability3.88480685
4MP0009379_abnormal_foot_pigmentation3.66889729
5MP0003136_yellow_coat_color3.22050999
6MP0003693_abnormal_embryo_hatching2.99244894
7MP0003111_abnormal_nucleus_morphology2.97597607
8MP0003077_abnormal_cell_cycle2.96586071
9MP0005409_darkened_coat_color2.91226769
10MP0008058_abnormal_DNA_repair2.83901432
11MP0002009_preneoplasia2.73862665
12MP0004957_abnormal_blastocyst_morpholog2.67058637
13MP0003045_fibrosis2.37181480
14MP0004859_abnormal_synaptic_plasticity2.35772686
15MP0008995_early_reproductive_senescence2.15490265
16MP0000350_abnormal_cell_proliferation1.90061318
17MP0008932_abnormal_embryonic_tissue1.87235287
18MP0002166_altered_tumor_susceptibility1.84472788
19MP0005174_abnormal_tail_pigmentation1.75745814
20MP0009780_abnormal_chondrocyte_physiolo1.73530797
21MP0003300_gastrointestinal_ulcer1.71564531
22MP0001346_abnormal_lacrimal_gland1.68801682
23MP0002877_abnormal_melanocyte_morpholog1.66968227
24MP0009697_abnormal_copulation1.64802640
25MP0008877_abnormal_DNA_methylation1.64766263
26MP0001188_hyperpigmentation1.64455010
27MP0008057_abnormal_DNA_replication1.63109796
28MP0004885_abnormal_endolymph1.62329793
29MP0000015_abnormal_ear_pigmentation1.55288687
30MP0005670_abnormal_white_adipose1.53797569
31MP0008007_abnormal_cellular_replicative1.53504745
32MP0001299_abnormal_eye_distance/1.53497628
33MP0001730_embryonic_growth_arrest1.52943210
34MP0004510_myositis1.50787480
35MP0000383_abnormal_hair_follicle1.50772772
36MP0001697_abnormal_embryo_size1.50426720
37MP0004381_abnormal_hair_follicle1.48810507
38MP0005187_abnormal_penis_morphology1.48764672
39MP0003868_abnormal_feces_composition1.46602040
40MP0010678_abnormal_skin_adnexa1.45409448
41MP0002006_tumorigenesis1.44710914
42MP0001486_abnormal_startle_reflex1.41228940
43MP0004808_abnormal_hematopoietic_stem1.41131889
44MP0009745_abnormal_behavioral_response1.40623265
45MP0002095_abnormal_skin_pigmentation1.39533095
46MP0005076_abnormal_cell_differentiation1.38579311
47MP0003635_abnormal_synaptic_transmissio1.38048118
48MP0003984_embryonic_growth_retardation1.36142519
49MP0001177_atelectasis1.36138455
50MP0005171_absent_coat_pigmentation1.34210759
51MP0005380_embryogenesis_phenotype1.31932715
52MP0001672_abnormal_embryogenesis/_devel1.31932715
53MP0003656_abnormal_erythrocyte_physiolo1.31596601
54MP0002088_abnormal_embryonic_growth/wei1.30958072
55MP0002928_abnormal_bile_duct1.30170881
56MP0001501_abnormal_sleep_pattern1.29708157
57MP0001286_abnormal_eye_development1.29536174
58MP0002084_abnormal_developmental_patter1.27863881
59MP0000631_abnormal_neuroendocrine_gland1.26990079
60MP0000313_abnormal_cell_death1.25396328
61MP0002697_abnormal_eye_size1.24931074
62MP0000566_synostosis1.24030377
63MP0002085_abnormal_embryonic_tissue1.22845299
64MP0009703_decreased_birth_body1.22176329
65MP0004197_abnormal_fetal_growth/weight/1.16663876
66MP0008961_abnormal_basal_metabolism1.16007492
67MP0002210_abnormal_sex_determination1.15244024
68MP0003935_abnormal_craniofacial_develop1.13423903
69MP0005646_abnormal_pituitary_gland1.11846526
70MP0002080_prenatal_lethality1.11308974
71MP0003937_abnormal_limbs/digits/tail_de1.09085868
72MP0003880_abnormal_central_pattern1.08118081
73MP0004147_increased_porphyrin_level1.08088479
74MP0002396_abnormal_hematopoietic_system1.07257733
75MP0003861_abnormal_nervous_system1.05951366
76MP0003121_genomic_imprinting1.05863752
77MP0003690_abnormal_glial_cell1.05030539
78MP0000537_abnormal_urethra_morphology1.04242328
79MP0002938_white_spotting1.03844730
80MP0005367_renal/urinary_system_phenotyp1.03672226
81MP0000516_abnormal_urinary_system1.03672226
82MP0003252_abnormal_bile_duct1.03141423
83MP0000703_abnormal_thymus_morphology1.01104479
84MP0005464_abnormal_platelet_physiology1.00727334
85MP0008569_lethality_at_weaning1.00663652
86MP0002876_abnormal_thyroid_physiology0.99479172
87MP0001929_abnormal_gametogenesis0.99243084
88MP0003938_abnormal_ear_development0.98191554
89MP0000778_abnormal_nervous_system0.96811801
90MP0006292_abnormal_olfactory_placode0.96379143
91MP0000432_abnormal_head_morphology0.96182447
92MP0003698_abnormal_male_reproductive0.96105955
93MP0003183_abnormal_peptide_metabolism0.95304395
94MP0000371_diluted_coat_color0.95216761
95MP0002075_abnormal_coat/hair_pigmentati0.93872698
96MP0003763_abnormal_thymus_physiology0.93854688
97MP0002064_seizures0.93511421
98MP0002572_abnormal_emotion/affect_behav0.93178724
99MP0001270_distended_abdomen0.92102363
100MP0002177_abnormal_outer_ear0.91578258
101MP0001851_eye_inflammation0.90754499
102MP0001790_abnormal_immune_system0.90469648
103MP0005387_immune_system_phenotype0.90469648
104MP0002067_abnormal_sensory_capabilities0.89239473
105MP0009672_abnormal_birth_weight0.89199373
106MP0002063_abnormal_learning/memory/cond0.89005301
107MP0000003_abnormal_adipose_tissue0.88717366
108MP0001145_abnormal_male_reproductive0.88395812
109MP0002086_abnormal_extraembryonic_tissu0.87668814
110MP0000372_irregular_coat_pigmentation0.87007690
111MP0009278_abnormal_bone_marrow0.86976650
112MP0002653_abnormal_ependyma_morphology0.85630889
113MP0003943_abnormal_hepatobiliary_system0.85120316
114MP0002081_perinatal_lethality0.82842601
115MP0000920_abnormal_myelination0.82646016
116MP0001879_abnormal_lymphatic_vessel0.82492110
117MP0004084_abnormal_cardiac_muscle0.82302961
118MP0001186_pigmentation_phenotype0.82297769
119MP0004145_abnormal_muscle_electrophysio0.82245630
120MP0001800_abnormal_humoral_immune0.82214486
121MP0000579_abnormal_nail_morphology0.82200167
122MP0005334_abnormal_fat_pad0.81801467
123MP0005423_abnormal_somatic_nervous0.81604807
124MP0002998_abnormal_bone_remodeling0.81575197
125MP0002735_abnormal_chemical_nociception0.79930244
126MP0001873_stomach_inflammation0.79864325
127MP0001661_extended_life_span0.78343690
128MP0002925_abnormal_cardiovascular_devel0.78049999
129MP0004134_abnormal_chest_morphology0.77931046
130MP0003890_abnormal_embryonic-extraembry0.77919586
131MP0003828_pulmonary_edema0.77868002
132MP0004130_abnormal_muscle_cell0.77806507
133MP0000653_abnormal_sex_gland0.77336906
134MP0001502_abnormal_circadian_rhythm0.76466529
135MP0005645_abnormal_hypothalamus_physiol0.76080799
136MP0010630_abnormal_cardiac_muscle0.75683834
137MP0001293_anophthalmia0.75379306
138MP0002971_abnormal_brown_adipose0.74796114
139MP0003942_abnormal_urinary_system0.74310373
140MP0002398_abnormal_bone_marrow0.74232690
141MP0005397_hematopoietic_system_phenotyp0.72979664
142MP0001545_abnormal_hematopoietic_system0.72979664
143MP0004484_altered_response_of0.72471077
144MP0004742_abnormal_vestibular_system0.71973183
145MP0004185_abnormal_adipocyte_glucose0.71930953
146MP0002736_abnormal_nociception_after0.71840158
147MP0000427_abnormal_hair_cycle0.71699965
148MP0001440_abnormal_grooming_behavior0.71684294
149MP0002249_abnormal_larynx_morphology0.71498624
150MP0000428_abnormal_craniofacial_morphol0.71375130
151MP0005375_adipose_tissue_phenotype0.71323054
152MP0010768_mortality/aging0.70364513
153MP0002693_abnormal_pancreas_physiology0.69586839
154MP0002272_abnormal_nervous_system0.69424550
155MP0002933_joint_inflammation0.69131352
156MP0010769_abnormal_survival0.68826853
157MP0002909_abnormal_adrenal_gland0.68668486
158MP0003091_abnormal_cell_migration0.68583365
159MP0001784_abnormal_fluid_regulation0.68384616
160MP0002019_abnormal_tumor_incidence0.68307477
161MP0008004_abnormal_stomach_pH0.67794492
162MP0002277_abnormal_respiratory_mucosa0.66995520
163MP0008770_decreased_survivor_rate0.66979696
164MP0005671_abnormal_response_to0.66425391
165MP0004142_abnormal_muscle_tone0.66260063
166MP0002082_postnatal_lethality0.65958386
167MP0010770_preweaning_lethality0.65958386
168MP0002168_other_aberrant_phenotype0.65925946
169MP0002152_abnormal_brain_morphology0.65502220
170MP0004264_abnormal_extraembryonic_tissu0.65271655
171MP0005220_abnormal_exocrine_pancreas0.64939475
172MP0002092_abnormal_eye_morphology0.64284777
173MP0003786_premature_aging0.62862173
174MP0005666_abnormal_adipose_tissue0.60873635
175MP0003115_abnormal_respiratory_system0.60613731
176MP0002161_abnormal_fertility/fecundity0.60533208

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.61576559
2Reticulocytopenia (HP:0001896)3.88425237
3Abnormality of cells of the erythroid lineage (HP:0012130)3.86270024
4Birth length less than 3rd percentile (HP:0003561)3.63469779
5Chromsome breakage (HP:0040012)3.58967523
6Absent frontal sinuses (HP:0002688)3.56704352
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50110771
8Abnormal number of erythroid precursors (HP:0012131)3.49307798
9Volvulus (HP:0002580)3.18156922
10Hypoplastic ischia (HP:0003175)3.13047946
11Abnormal number of incisors (HP:0011064)2.97933132
12Abnormality of the ischium (HP:0003174)2.85364203
13Macroorchidism (HP:0000053)2.78522795
14Macrocytic anemia (HP:0001972)2.78072617
15Narrow palate (HP:0000189)2.75994589
16Duplicated collecting system (HP:0000081)2.63247744
17Febrile seizures (HP:0002373)2.59628636
18Pallor (HP:0000980)2.58213853
19Syringomyelia (HP:0003396)2.57924237
20Spinal cord lesions (HP:0100561)2.57924237
21Lip pit (HP:0100267)2.57071070
22Increased nuchal translucency (HP:0010880)2.56638550
23Abnormality of the nasal septum (HP:0000419)2.47876896
24Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.46891821
25Prolonged bleeding time (HP:0003010)2.44490380
26Supernumerary ribs (HP:0005815)2.43898265
27Abnormality of cochlea (HP:0000375)2.43341740
28Abnormality of incisor morphology (HP:0011063)2.41608335
29Myelodysplasia (HP:0002863)2.36296710
30Short middle phalanx of the 5th finger (HP:0004220)2.34027705
31Aqueductal stenosis (HP:0002410)2.33982207
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31896114
33Distal lower limb amyotrophy (HP:0008944)2.29518370
34Chronic hepatic failure (HP:0100626)2.29230971
35Hyperkalemia (HP:0002153)2.29117529
36Protruding tongue (HP:0010808)2.28710798
37Abnormality of the frontal sinuses (HP:0002687)2.28666491
38Abnormality of reticulocytes (HP:0004312)2.28247923
39Generalized hypopigmentation of hair (HP:0011358)2.27085904
40Hypochromic microcytic anemia (HP:0004840)2.27001903
41Genetic anticipation (HP:0003743)2.24545401
42Overlapping toe (HP:0001845)2.23029175
43Abnormal ciliary motility (HP:0012262)2.21758578
44Supernumerary bones of the axial skeleton (HP:0009144)2.20937301
45Widely spaced teeth (HP:0000687)2.18425478
46Long eyelashes (HP:0000527)2.18259776
47Morphological abnormality of the inner ear (HP:0011390)2.18038360
48Oligodactyly (hands) (HP:0001180)2.17628799
49Fair hair (HP:0002286)2.13753380
50Obsessive-compulsive behavior (HP:0000722)2.13660314
51Abnormal respiratory motile cilium physiology (HP:0012261)2.11778709
52Abnormality of the parietal bone (HP:0002696)2.09522827
53Abnormality of the renal collecting system (HP:0004742)2.09261232
54Calcaneovalgus deformity (HP:0001848)2.08662005
55Anal stenosis (HP:0002025)2.08280340
56Increased mean platelet volume (HP:0011877)2.08111853
57Septate vagina (HP:0001153)2.04820387
58Bell-shaped thorax (HP:0001591)2.04656216
59Lower limb amyotrophy (HP:0007210)2.04448451
60Abnormality of chromosome stability (HP:0003220)2.04191127
61Truncus arteriosus (HP:0001660)2.03689630
62Bowel incontinence (HP:0002607)2.03593887
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.03158329
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03158329
65Duplication of thumb phalanx (HP:0009942)2.00162458
6611 pairs of ribs (HP:0000878)1.99893368
67Missing ribs (HP:0000921)1.99782471
68Abnormal large intestine physiology (HP:0012700)1.99748982
69Poikilocytosis (HP:0004447)1.98212846
70Broad-based gait (HP:0002136)1.97739905
71Sandal gap (HP:0001852)1.97487451
72Abnormality of the diencephalon (HP:0010662)1.96987126
73Excessive salivation (HP:0003781)1.96640369
74Drooling (HP:0002307)1.96640369
75Urethral obstruction (HP:0000796)1.95995084
76Abnormality of the carotid arteries (HP:0005344)1.95149258
77Abnormality of chromosome segregation (HP:0002916)1.89787552
78Truncal obesity (HP:0001956)1.88341126
79Acute myeloid leukemia (HP:0004808)1.86485581
80Blue irides (HP:0000635)1.86302722
81Deformed tarsal bones (HP:0008119)1.86088245
82Epiphyseal dysplasia (HP:0002656)1.85830817
83T lymphocytopenia (HP:0005403)1.85724686
84Long clavicles (HP:0000890)1.84918578
85Deep philtrum (HP:0002002)1.83899785
86Submucous cleft hard palate (HP:0000176)1.83304628
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.83023093
88Limited hip movement (HP:0008800)1.82347193
89Dysmetric saccades (HP:0000641)1.80031299
90Hypoplastic labia majora (HP:0000059)1.79749946
91Thyroiditis (HP:0100646)1.79715886
92Patellar aplasia (HP:0006443)1.77856934
93Triphalangeal thumb (HP:0001199)1.77589151
94Abnormal respiratory epithelium morphology (HP:0012253)1.77579125
95Abnormal respiratory motile cilium morphology (HP:0005938)1.77579125
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.77462848
97Vertebral arch anomaly (HP:0008438)1.77331051
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.76917407
99Rhinitis (HP:0012384)1.76009761
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75982515
101Depressed nasal tip (HP:0000437)1.75378639
102Transitional cell carcinoma of the bladder (HP:0006740)1.75282262
103Gaze-evoked nystagmus (HP:0000640)1.75249370
104Abnormality of lateral ventricle (HP:0030047)1.74984305
105Limited elbow extension (HP:0001377)1.74758685
106Thick eyebrow (HP:0000574)1.74010971
107Hypoplasia of the iris (HP:0007676)1.73421298
108Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72668464
109Trigonocephaly (HP:0000243)1.71917449
110Low anterior hairline (HP:0000294)1.71727161
111Tubulointerstitial nephritis (HP:0001970)1.71610050
112Neoplasm of the tracheobronchial system (HP:0100552)1.71220395
113Abnormal platelet volume (HP:0011876)1.71191789
114Abnormality of T cell number (HP:0011839)1.70769724
115Impulsivity (HP:0100710)1.70210737
116Acute lymphatic leukemia (HP:0006721)1.69819929
117Mesomelia (HP:0003027)1.69714805
118Ankyloglossia (HP:0010296)1.69050962
119Hypoplasia of the maxilla (HP:0000327)1.69001013
120Coarctation of aorta (HP:0001680)1.68809040
121Focal motor seizures (HP:0011153)1.68075694
122Small epiphyses (HP:0010585)1.67913344
123Abnormal hair whorl (HP:0010721)1.67835129
124Optic nerve coloboma (HP:0000588)1.67780527
125Abnormality of the incisor (HP:0000676)1.67237121
126Pseudobulbar signs (HP:0002200)1.66851190
127Seborrheic dermatitis (HP:0001051)1.66574359
128Asymmetry of the thorax (HP:0001555)1.66527475
129Heterotopia (HP:0002282)1.66003351
130Abnormality of the preputium (HP:0100587)1.65967404
131Abnormality of homocysteine metabolism (HP:0010919)1.65395260
132Homocystinuria (HP:0002156)1.65395260
133Abnormality of the labia majora (HP:0012881)1.65354065
134Tapered finger (HP:0001182)1.65007783
135Broad metatarsal (HP:0001783)1.64859784
136Absent/shortened dynein arms (HP:0200106)1.64459289
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.64459289
138Papillary thyroid carcinoma (HP:0002895)1.63453894
139Nasolacrimal duct obstruction (HP:0000579)1.62557161
140Limb hypertonia (HP:0002509)1.61875411
141Breast hypoplasia (HP:0003187)1.61828966
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61517510
143Termporal pattern (HP:0011008)1.61393855
144Insidious onset (HP:0003587)1.61393855
145Neoplasm of the adrenal cortex (HP:0100641)1.60784425
146Inappropriate behavior (HP:0000719)1.60432675
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60091006
148Smooth philtrum (HP:0000319)1.60057537
149Chronic diarrhea (HP:0002028)1.59890859
150Cutis marmorata (HP:0000965)1.59813229
151Ectopic kidney (HP:0000086)1.59698474
152Abnormality of the left ventricular outflow tract (HP:0011103)1.58780453
153Subaortic stenosis (HP:0001682)1.58780453
154Short middle phalanx of finger (HP:0005819)1.58736908
155Short thumb (HP:0009778)1.57844639
156Absent radius (HP:0003974)1.57572610
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.57130446
158Cortical dysplasia (HP:0002539)1.56666298
159Atresia of the external auditory canal (HP:0000413)1.56643334
160Spondylolisthesis (HP:0003302)1.56585522
161Hypoplastic nipples (HP:0002557)1.56360490
162Tented upper lip vermilion (HP:0010804)1.55968418
163Midline defect of the nose (HP:0004122)1.55215616
164Synophrys (HP:0000664)1.52317126
165Renovascular hypertension (HP:0100817)1.51960912
166Deeply set eye (HP:0000490)1.50890113
167Hip contracture (HP:0003273)1.50271957
168Ectropion (HP:0000656)1.48969117
169Progressive cerebellar ataxia (HP:0002073)1.48533679
170Absent speech (HP:0001344)1.46319690
171Exotropia (HP:0000577)1.46047677
172Bladder carcinoma (HP:0002862)1.45985963
173Bladder neoplasm (HP:0009725)1.45985963
174Macrotia (HP:0000400)1.45924775
175Aplasia cutis congenita (HP:0001057)1.44435926
176Abnormality of the right ventricle (HP:0001707)1.43903791
177Chin dimple (HP:0010751)1.43839017
178Leiomyosarcoma (HP:0100243)1.43482170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD43.91038037
2CDC73.72974232
3CAMK1G2.82756968
4CDK122.67532173
5INSRR2.52280341
6MAP3K102.40173402
7PASK2.38980221
8MKNK22.35588639
9NTRK32.30289961
10WEE12.30247678
11TNIK2.28390016
12CAMK1D2.17741126
13SIK22.10643797
14EIF2AK12.04172711
15MAP3K141.85848922
16LATS11.84337639
17TTK1.78129123
18IRAK31.76752486
19SGK21.75056294
20BRSK21.72072065
21MAP3K131.69998128
22MAPK151.66755894
23WNK11.62138722
24SGK31.59662963
25FRK1.57693365
26FGFR21.56554216
27EPHA41.55282183
28NUAK11.53126542
29RPS6KA41.52085937
30TAOK31.51822429
31ZAK1.48239019
32CHEK21.45423998
33MST41.43932248
34ATR1.40686954
35NEK21.38124756
36EEF2K1.34687503
37TXK1.30841713
38TSSK61.30581151
39JAK11.27641996
40TYRO31.25472626
41MAP3K71.24157706
42CDK41.21139287
43BMX1.19762821
44PLK41.19015712
45CHEK11.16864011
46PNCK1.16628351
47RIPK41.15888171
48SGK11.15885576
49IRAK41.15843233
50SIK11.13647106
51CDC42BPA1.12258027
52DYRK31.09912400
53PIK3CA1.09876625
54MKNK11.09264853
55PDGFRB1.06033175
56FGFR31.05527493
57FES1.05397760
58TAF11.03688128
59AKT31.02319150
60YES11.01969504
61HIPK21.01949180
62NEK61.01726372
63DMPK0.99206255
64MARK20.98581085
65CDK90.97717720
66RPS6KB20.92755822
67CDK20.92217366
68PRKAA20.90771469
69TRPM70.90305563
70SGK2230.88382893
71SGK4940.88382893
72CDK10.87588866
73VRK10.87563513
74CSNK1E0.86138167
75CDK70.83158235
76PRKCH0.82087631
77UHMK10.80754517
78PKN10.79753970
79BTK0.78728268
80PRKCQ0.77495766
81PLK30.77264738
82TNK20.74513664
83AURKB0.74339977
84CLK10.72230588
85VRK20.71769509
86EPHB10.71355637
87CDK60.70951827
88CHUK0.70434363
89CDK30.70247083
90STK30.68498576
91MAPK70.68055969
92ITK0.67952958
93HCK0.67472998
94MAP4K10.66449525
95ERBB30.66366909
96PDGFRA0.64647368
97IRAK20.64456042
98CSK0.63980696
99TTN0.63815036
100MAPK130.63612628
101STK240.63161413
102PTK60.61954584
103CAMK40.61517508
104NME10.61407581
105KSR10.58557952
106MAPK100.58481337
107ALK0.57963313
108JAK30.57574233
109PRPF4B0.56584717
110RPS6KA50.56568451
111PLK10.56322199
112RPS6KB10.56048674
113NLK0.55880287
114CSNK2A20.54510857
115CAMK10.54413475
116STK380.53811305
117ATM0.53414148
118PRKD20.52534679
119MAPK140.51085074
120MAP3K40.50950694
121PRKDC0.50473948
122DYRK1A0.49806875
123STK40.49492270
124ICK0.49213722
125PIM10.48845663
126TEC0.48344673
127TLK10.48280288
128GSK3B0.47743901
129LCK0.47285434
130PRKG10.46762727
131TRIB30.46559883
132BMPR20.45980654
133AKT10.45585292
134OBSCN0.44203833
135MTOR0.43974505
136ABL10.43679459
137MARK30.43252206
138MAPK80.42837244
139CAMKK10.42321377
140CDK80.42220822
141SRPK10.42055690
142EPHA30.41439803
143RPS6KA30.40959724
144CSNK1D0.40347859
145FGR0.39751314
146MAPK120.39544794
147IRAK10.39392846
148RAF10.39053119
149DDR20.38747305
150MAPK110.36214200
151CCNB10.33674801
152DYRK20.33315423
153KSR20.33071101
154NTRK20.32987300
155RET0.31174469

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.84334222
2Ribosome_Homo sapiens_hsa030103.77739014
3DNA replication_Homo sapiens_hsa030303.45586595
4Mismatch repair_Homo sapiens_hsa034303.15373533
5Cell cycle_Homo sapiens_hsa041102.60491283
6RNA transport_Homo sapiens_hsa030132.57956786
7Homologous recombination_Homo sapiens_hsa034402.40443325
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33319823
9mRNA surveillance pathway_Homo sapiens_hsa030152.30587575
10Lysine degradation_Homo sapiens_hsa003102.26498592
11Nucleotide excision repair_Homo sapiens_hsa034202.06886660
12Basal transcription factors_Homo sapiens_hsa030222.00819927
13Fanconi anemia pathway_Homo sapiens_hsa034601.97566455
14Base excision repair_Homo sapiens_hsa034101.89043531
15Non-homologous end-joining_Homo sapiens_hsa034501.81408479
16Nicotine addiction_Homo sapiens_hsa050331.75396016
17Caffeine metabolism_Homo sapiens_hsa002321.73444150
18One carbon pool by folate_Homo sapiens_hsa006701.67519969
19RNA degradation_Homo sapiens_hsa030181.67493135
20Type II diabetes mellitus_Homo sapiens_hsa049301.65349660
21Long-term potentiation_Homo sapiens_hsa047201.64905673
22Glutamatergic synapse_Homo sapiens_hsa047241.62254763
23RNA polymerase_Homo sapiens_hsa030201.58386892
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53623555
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51125410
26Circadian entrainment_Homo sapiens_hsa047131.48429115
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40455813
28Renal cell carcinoma_Homo sapiens_hsa052111.36002477
29Dorso-ventral axis formation_Homo sapiens_hsa043201.35892702
30Morphine addiction_Homo sapiens_hsa050321.33434200
31Amphetamine addiction_Homo sapiens_hsa050311.31902316
32Taste transduction_Homo sapiens_hsa047421.30683632
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29629903
34B cell receptor signaling pathway_Homo sapiens_hsa046621.29039338
35Renin secretion_Homo sapiens_hsa049241.26576649
36Thyroid cancer_Homo sapiens_hsa052161.25777693
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21785166
38cAMP signaling pathway_Homo sapiens_hsa040241.20956738
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19987194
40T cell receptor signaling pathway_Homo sapiens_hsa046601.18666471
41Calcium signaling pathway_Homo sapiens_hsa040201.18227025
42Primary immunodeficiency_Homo sapiens_hsa053401.18004340
43Nitrogen metabolism_Homo sapiens_hsa009101.14821455
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.14638527
45Colorectal cancer_Homo sapiens_hsa052101.14532185
46Salivary secretion_Homo sapiens_hsa049701.14455874
47Huntingtons disease_Homo sapiens_hsa050161.14080620
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11577118
49Insulin secretion_Homo sapiens_hsa049111.11329870
50Long-term depression_Homo sapiens_hsa047301.07554690
51Oxytocin signaling pathway_Homo sapiens_hsa049211.06738216
52Pyrimidine metabolism_Homo sapiens_hsa002401.06217886
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04726343
54Prostate cancer_Homo sapiens_hsa052151.03120625
55GABAergic synapse_Homo sapiens_hsa047271.02291235
56Choline metabolism in cancer_Homo sapiens_hsa052311.00822480
57Cholinergic synapse_Homo sapiens_hsa047251.00061861
58Circadian rhythm_Homo sapiens_hsa047100.99374381
59Dilated cardiomyopathy_Homo sapiens_hsa054140.99355761
60Olfactory transduction_Homo sapiens_hsa047400.99171465
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98934424
62Purine metabolism_Homo sapiens_hsa002300.98869077
63ABC transporters_Homo sapiens_hsa020100.98238775
64Insulin resistance_Homo sapiens_hsa049310.97293659
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95396003
66MicroRNAs in cancer_Homo sapiens_hsa052060.95119694
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94805723
68Osteoclast differentiation_Homo sapiens_hsa043800.94693556
69Hematopoietic cell lineage_Homo sapiens_hsa046400.94461880
70Cardiac muscle contraction_Homo sapiens_hsa042600.93780826
71Oocyte meiosis_Homo sapiens_hsa041140.93419010
72Gastric acid secretion_Homo sapiens_hsa049710.93154113
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91615704
74Inositol phosphate metabolism_Homo sapiens_hsa005620.91383776
75ECM-receptor interaction_Homo sapiens_hsa045120.90386420
76ErbB signaling pathway_Homo sapiens_hsa040120.90188589
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89653612
78Parkinsons disease_Homo sapiens_hsa050120.89632673
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88664134
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88596219
81Cocaine addiction_Homo sapiens_hsa050300.87499810
82Adherens junction_Homo sapiens_hsa045200.87384598
83GnRH signaling pathway_Homo sapiens_hsa049120.87024605
84Basal cell carcinoma_Homo sapiens_hsa052170.86900598
85Viral carcinogenesis_Homo sapiens_hsa052030.86837660
86Dopaminergic synapse_Homo sapiens_hsa047280.86791914
87FoxO signaling pathway_Homo sapiens_hsa040680.85406891
88Pancreatic secretion_Homo sapiens_hsa049720.85120625
89MAPK signaling pathway_Homo sapiens_hsa040100.84389366
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83943793
91Platelet activation_Homo sapiens_hsa046110.83783248
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83729873
93Glioma_Homo sapiens_hsa052140.81892816
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80535864
95mTOR signaling pathway_Homo sapiens_hsa041500.79842196
96Chemokine signaling pathway_Homo sapiens_hsa040620.79313985
97Chronic myeloid leukemia_Homo sapiens_hsa052200.78759656
98Axon guidance_Homo sapiens_hsa043600.78285496
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78129071
100Glucagon signaling pathway_Homo sapiens_hsa049220.77770470
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76528084
102Epstein-Barr virus infection_Homo sapiens_hsa051690.75141348
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.74867445
104Ovarian steroidogenesis_Homo sapiens_hsa049130.74367558
105Focal adhesion_Homo sapiens_hsa045100.73808141
106Gap junction_Homo sapiens_hsa045400.73758721
107Wnt signaling pathway_Homo sapiens_hsa043100.73542540
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.73295929
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72705777
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71464202
111Non-small cell lung cancer_Homo sapiens_hsa052230.71284006
112Estrogen signaling pathway_Homo sapiens_hsa049150.70790124
113Measles_Homo sapiens_hsa051620.70760560
114HTLV-I infection_Homo sapiens_hsa051660.69441287
115Serotonergic synapse_Homo sapiens_hsa047260.68850934
116Melanogenesis_Homo sapiens_hsa049160.67395371
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67224551
118Oxidative phosphorylation_Homo sapiens_hsa001900.67151305
119Acute myeloid leukemia_Homo sapiens_hsa052210.66938939
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66478779
121Protein export_Homo sapiens_hsa030600.66103615
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65358573
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65184450
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64812467
125Small cell lung cancer_Homo sapiens_hsa052220.64640400
126Notch signaling pathway_Homo sapiens_hsa043300.64269921
127Hedgehog signaling pathway_Homo sapiens_hsa043400.63307308
128TGF-beta signaling pathway_Homo sapiens_hsa043500.62377129
129Endometrial cancer_Homo sapiens_hsa052130.61305653
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.60415017
131Thyroid hormone synthesis_Homo sapiens_hsa049180.60376645
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59768569
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.59213239
134Pathways in cancer_Homo sapiens_hsa052000.58613717
135Proteoglycans in cancer_Homo sapiens_hsa052050.57916307
136Hepatitis B_Homo sapiens_hsa051610.57605926
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.57175963
138Pancreatic cancer_Homo sapiens_hsa052120.56681148
139Alcoholism_Homo sapiens_hsa050340.56223288
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55908613
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55829891
142Prolactin signaling pathway_Homo sapiens_hsa049170.55741798
143Melanoma_Homo sapiens_hsa052180.55722713
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53343147
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52569911
146Protein digestion and absorption_Homo sapiens_hsa049740.52540470
147VEGF signaling pathway_Homo sapiens_hsa043700.50681585
148p53 signaling pathway_Homo sapiens_hsa041150.45974748
149Alzheimers disease_Homo sapiens_hsa050100.42075394
150Herpes simplex infection_Homo sapiens_hsa051680.38083652
151HIF-1 signaling pathway_Homo sapiens_hsa040660.33221717
152Bladder cancer_Homo sapiens_hsa052190.31595769

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