LUC7L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)4.68683278
2glutamate receptor signaling pathway (GO:0007215)4.52675692
3G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.40819145
4pyrimidine nucleobase catabolic process (GO:0006208)4.35669157
5behavioral response to nicotine (GO:0035095)4.27953052
6presynaptic membrane assembly (GO:0097105)4.13470269
7somite development (GO:0061053)4.07789937
8neuron cell-cell adhesion (GO:0007158)4.02840881
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.01684620
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99087946
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.92753599
12synaptic transmission, glutamatergic (GO:0035249)3.90785861
13vocalization behavior (GO:0071625)3.86060322
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.84427986
15histone H3-K4 trimethylation (GO:0080182)3.78080168
16presynaptic membrane organization (GO:0097090)3.69996925
17neuron-neuron synaptic transmission (GO:0007270)3.65954194
18startle response (GO:0001964)3.63786514
19protein localization to synapse (GO:0035418)3.57628962
20nucleobase catabolic process (GO:0046113)3.51544948
21negative regulation of synaptic transmission, GABAergic (GO:0032229)3.51236191
22postsynaptic membrane organization (GO:0001941)3.48218070
23retina layer formation (GO:0010842)3.46699583
24cerebellar Purkinje cell differentiation (GO:0021702)3.44677756
25centriole replication (GO:0007099)3.41810028
26regulation of glutamate receptor signaling pathway (GO:1900449)3.39448679
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.38996490
28neuron recognition (GO:0008038)3.34787221
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27035976
30cell proliferation in forebrain (GO:0021846)3.21427815
31central nervous system projection neuron axonogenesis (GO:0021952)3.15390579
32locomotory exploration behavior (GO:0035641)3.15018879
33* mRNA splice site selection (GO:0006376)3.13601941
34dendritic spine morphogenesis (GO:0060997)3.13291579
35transmission of nerve impulse (GO:0019226)3.12624084
36L-amino acid import (GO:0043092)3.12198539
37auditory behavior (GO:0031223)3.10800360
38axonal fasciculation (GO:0007413)3.09784437
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08769012
40axon ensheathment in central nervous system (GO:0032291)3.06090283
41central nervous system myelination (GO:0022010)3.06090283
42synaptic vesicle endocytosis (GO:0048488)3.02995402
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02675639
44peptidyl-lysine trimethylation (GO:0018023)3.02407312
45gamma-aminobutyric acid transport (GO:0015812)3.01355554
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.01195031
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00672457
48viral transcription (GO:0019083)2.99848877
49long-term memory (GO:0007616)2.98429603
50neuronal action potential propagation (GO:0019227)2.98124475
51mechanosensory behavior (GO:0007638)2.96502044
52translational termination (GO:0006415)2.95841750
53epithelial cilium movement (GO:0003351)2.95139014
54cerebral cortex radially oriented cell migration (GO:0021799)2.92919817
55otic vesicle formation (GO:0030916)2.92822959
56atrial cardiac muscle cell action potential (GO:0086014)2.92748229
57righting reflex (GO:0060013)2.91094938
58synaptic vesicle exocytosis (GO:0016079)2.90389316
59kidney morphogenesis (GO:0060993)2.88097406
60positive regulation of dendritic spine morphogenesis (GO:0061003)2.87732092
61cerebellar granule cell differentiation (GO:0021707)2.87293222
62intraciliary transport (GO:0042073)2.87035069
63regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85613272
64synaptic vesicle docking involved in exocytosis (GO:0016081)2.84871651
65hindbrain development (GO:0030902)2.84118254
66positive regulation of synapse maturation (GO:0090129)2.83706957
67spinal cord development (GO:0021510)2.82875490
68regulation of postsynaptic membrane potential (GO:0060078)2.82419653
69amino acid import (GO:0043090)2.81293318
70neuron projection extension involved in neuron projection guidance (GO:1902284)2.79597770
71axon extension involved in axon guidance (GO:0048846)2.79597770
72regulation of synaptic vesicle exocytosis (GO:2000300)2.79412874
73positive regulation of growth hormone secretion (GO:0060124)2.78493630
74histone H3-K9 methylation (GO:0051567)2.78474453
75neurotransmitter-gated ion channel clustering (GO:0072578)2.77244600
76layer formation in cerebral cortex (GO:0021819)2.75010702
77positive regulation of synapse assembly (GO:0051965)2.74972609
78neural tube formation (GO:0001841)2.73065623
79forebrain morphogenesis (GO:0048853)2.72004285
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70861047
81dendrite morphogenesis (GO:0048813)2.70349102
82mitochondrion transport along microtubule (GO:0047497)2.69168209
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69168209
84cellular potassium ion homeostasis (GO:0030007)2.69073285
85negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67748105
86negative regulation of translation, ncRNA-mediated (GO:0040033)2.67748105
87regulation of translation, ncRNA-mediated (GO:0045974)2.67748105
88synapse assembly (GO:0007416)2.66822719
89regulation of growth hormone secretion (GO:0060123)2.65144308
90neuromuscular synaptic transmission (GO:0007274)2.64946176
91retinal ganglion cell axon guidance (GO:0031290)2.64693535
92synaptic vesicle maturation (GO:0016188)2.64669641
93membrane depolarization during action potential (GO:0086010)2.64627684
94regulation of DNA endoreduplication (GO:0032875)2.62702088
95response to pheromone (GO:0019236)2.62239453
96negative regulation of astrocyte differentiation (GO:0048712)2.62195209
97cell differentiation in hindbrain (GO:0021533)2.61633004
98regulation of synapse maturation (GO:0090128)2.60565338
99regulation of respiratory system process (GO:0044065)2.58445832
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.56702729
101nonmotile primary cilium assembly (GO:0035058)2.56341362
102eye photoreceptor cell development (GO:0042462)2.56337480
103central nervous system neuron axonogenesis (GO:0021955)2.55581159
104glutamate secretion (GO:0014047)2.55028680
105positive regulation of dendritic spine development (GO:0060999)2.54741554
106regulation of mRNA splicing, via spliceosome (GO:0048024)2.53654036
107negative regulation of neurotransmitter secretion (GO:0046929)2.53527711
108neurotransmitter secretion (GO:0007269)2.52933629
109regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52218818
110head development (GO:0060322)2.52133897
111cranial nerve structural organization (GO:0021604)2.51814074
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51578075
113response to auditory stimulus (GO:0010996)2.51029179
114regulation of synapse assembly (GO:0051963)2.50523785
115response to histamine (GO:0034776)2.50232753
116adult walking behavior (GO:0007628)2.50220597
117cell migration in hindbrain (GO:0021535)2.50137309
118innervation (GO:0060384)2.49483320
119replication fork processing (GO:0031297)2.49185130
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.48514737
121photoreceptor cell development (GO:0042461)2.48488527
122membrane depolarization (GO:0051899)2.48485011
123exploration behavior (GO:0035640)2.47888713
124behavioral defense response (GO:0002209)2.47786921
125behavioral fear response (GO:0001662)2.47786921
126regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46459414
127fear response (GO:0042596)2.46186177
128regulation of synaptic vesicle transport (GO:1902803)2.44380347
129nucleus localization (GO:0051647)2.44297320
130regulation of dendritic spine morphogenesis (GO:0061001)2.43876682
131limb bud formation (GO:0060174)2.43356020
132ribosomal small subunit assembly (GO:0000028)2.42946655
133regulation of neuronal synaptic plasticity (GO:0048168)2.42310524
134positive regulation of membrane potential (GO:0045838)2.42285001
135establishment of mitochondrion localization (GO:0051654)2.41553077
136membrane hyperpolarization (GO:0060081)2.40197090
137regulation of long-term neuronal synaptic plasticity (GO:0048169)2.39749258
138spinal cord association neuron differentiation (GO:0021527)2.39388690
139cilium movement (GO:0003341)2.38962986
140cilium organization (GO:0044782)2.38867895
141cilium assembly (GO:0042384)2.38782186
142neuronal stem cell maintenance (GO:0097150)2.38712529
143regulation of cilium movement (GO:0003352)2.38321093
144cell differentiation in spinal cord (GO:0021515)2.37662468
145regulation of neurotransmitter secretion (GO:0046928)2.37262779
146negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35892004
147resolution of meiotic recombination intermediates (GO:0000712)2.35733168
148substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.33266131
149substrate-independent telencephalic tangential migration (GO:0021826)2.33266131
150protein localization to cilium (GO:0061512)2.33093921
151calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32708679
152dentate gyrus development (GO:0021542)2.32153693
153forebrain neuron differentiation (GO:0021879)2.31852621
154centriole assembly (GO:0098534)2.31798586
155cellular response to cholesterol (GO:0071397)2.31116205
156negative regulation of transcription regulatory region DNA binding (GO:2000678)2.29950871
157regulation of telomere maintenance (GO:0032204)2.29783260
158negative regulation of neurotransmitter transport (GO:0051589)2.29012691
159brain morphogenesis (GO:0048854)2.28917200
160seminiferous tubule development (GO:0072520)2.28726844
161regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.27858753
162behavioral response to ethanol (GO:0048149)2.27710494
163dendrite development (GO:0016358)2.27493621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49134383
2GBX2_23144817_ChIP-Seq_PC3_Human4.23045403
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.72861043
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65975404
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49790898
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38560495
7TAF15_26573619_Chip-Seq_HEK293_Human2.30087930
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28599214
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26130562
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.25916791
11FUS_26573619_Chip-Seq_HEK293_Human2.19745595
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15979241
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11702689
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11702689
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10010630
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.09635727
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08890811
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06605478
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03928918
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01153148
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01051680
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00445676
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98079615
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.94435277
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91656996
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87156162
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86942277
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84494801
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.84311573
30REST_21632747_ChIP-Seq_MESCs_Mouse1.81889315
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79653454
32P300_19829295_ChIP-Seq_ESCs_Human1.79073621
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75346800
34DROSHA_22980978_ChIP-Seq_HELA_Human1.72379001
35AR_21572438_ChIP-Seq_LNCaP_Human1.71995345
36SMAD4_21799915_ChIP-Seq_A2780_Human1.70156540
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69522032
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.67609249
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66338873
40EWS_26573619_Chip-Seq_HEK293_Human1.61015278
41IGF1R_20145208_ChIP-Seq_DFB_Human1.60117250
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59990807
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59544669
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57471868
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.57385882
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.57295452
47RNF2_27304074_Chip-Seq_NSC_Mouse1.56163659
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55522144
49IRF1_19129219_ChIP-ChIP_H3396_Human1.54799263
50TP53_16413492_ChIP-PET_HCT116_Human1.54748838
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.53056377
52STAT3_23295773_ChIP-Seq_U87_Human1.52737383
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52205712
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51976718
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51665747
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48578619
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46165200
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46165200
59ZNF274_21170338_ChIP-Seq_K562_Hela1.42532430
60* RARB_27405468_Chip-Seq_BRAIN_Mouse1.41695327
61ER_23166858_ChIP-Seq_MCF-7_Human1.41489914
62TCF4_23295773_ChIP-Seq_U87_Human1.41419647
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.40700330
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38193982
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36095201
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34920549
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34334916
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34256886
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34217131
70MYC_18940864_ChIP-ChIP_HL60_Human1.34216385
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31221966
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31034069
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.29874745
74E2F7_22180533_ChIP-Seq_HELA_Human1.29215869
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29025547
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28883882
77AR_25329375_ChIP-Seq_VCAP_Human1.27167953
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.26977382
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26486788
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26127857
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25839782
82VDR_22108803_ChIP-Seq_LS180_Human1.25588939
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25528914
84RUNX2_22187159_ChIP-Seq_PCA_Human1.24867327
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.24498210
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.24397135
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22364683
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21120124
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21094074
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20615224
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.20484748
92AR_19668381_ChIP-Seq_PC3_Human1.19573297
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19331300
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19186685
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18830642
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.18714086
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.18469902
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17985482
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16646989
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15831354
101P53_22387025_ChIP-Seq_ESCs_Mouse1.15334327
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.15146019
103CBP_20019798_ChIP-Seq_JUKART_Human1.15061273
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15061273
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14823431
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14025558
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.13336177
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12830626
109SOX9_26525672_Chip-Seq_HEART_Mouse1.11097143
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10805391
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09623036
112SALL1_21062744_ChIP-ChIP_HESCs_Human1.09454402
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08437956
114P300_18555785_Chip-Seq_ESCs_Mouse1.08157094
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08028068
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06755742
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.05827627
118E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03434367
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02466336
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.97972133
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.97032628
122WDR5_24793694_ChIP-Seq_LNCAP_Human0.96076936
123ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95884542
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92100266
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91750390
126* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90459567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.00233591
2MP0003880_abnormal_central_pattern3.62345406
3MP0004859_abnormal_synaptic_plasticity3.62005229
4MP0005409_darkened_coat_color2.88024998
5MP0004270_analgesia2.74929666
6MP0003635_abnormal_synaptic_transmissio2.74634142
7MP0003136_yellow_coat_color2.71373633
8MP0001486_abnormal_startle_reflex2.47247867
9MP0005423_abnormal_somatic_nervous2.44343299
10MP0009379_abnormal_foot_pigmentation2.42575760
11MP0009745_abnormal_behavioral_response2.41732742
12MP0001188_hyperpigmentation2.25648146
13MP0000778_abnormal_nervous_system2.18501572
14MP0009046_muscle_twitch2.18468716
15MP0002063_abnormal_learning/memory/cond2.16085760
16MP0006292_abnormal_olfactory_placode2.15894188
17MP0003121_genomic_imprinting2.13608165
18MP0002064_seizures2.10931715
19MP0002572_abnormal_emotion/affect_behav2.08140220
20MP0002734_abnormal_mechanical_nocicepti2.01041870
21MP0001968_abnormal_touch/_nociception1.99863751
22MP0002272_abnormal_nervous_system1.92432833
23MP0005551_abnormal_eye_electrophysiolog1.92031455
24MP0008789_abnormal_olfactory_epithelium1.87673054
25MP0000566_synostosis1.82245170
26MP0008877_abnormal_DNA_methylation1.81263402
27MP0002067_abnormal_sensory_capabilities1.77678912
28MP0006072_abnormal_retinal_apoptosis1.76675819
29MP0001293_anophthalmia1.75011792
30MP0001440_abnormal_grooming_behavior1.74593193
31MP0002735_abnormal_chemical_nociception1.71023073
32MP0002557_abnormal_social/conspecific_i1.68713286
33MP0003122_maternal_imprinting1.66298320
34MP0002184_abnormal_innervation1.62052536
35MP0000569_abnormal_digit_pigmentation1.61392493
36MP0002736_abnormal_nociception_after1.56585741
37MP0001529_abnormal_vocalization1.55408299
38MP0008057_abnormal_DNA_replication1.51872720
39MP0004742_abnormal_vestibular_system1.48374366
40MP0010030_abnormal_orbit_morphology1.48044139
41MP0004145_abnormal_muscle_electrophysio1.47342064
42MP0002234_abnormal_pharynx_morphology1.45161491
43MP0002653_abnormal_ependyma_morphology1.43945202
44MP0000631_abnormal_neuroendocrine_gland1.43405353
45MP0001502_abnormal_circadian_rhythm1.43294536
46MP0001485_abnormal_pinna_reflex1.36622661
47MP0002882_abnormal_neuron_morphology1.35267924
48MP0004885_abnormal_endolymph1.35264283
49MP0002102_abnormal_ear_morphology1.35238646
50MP0005253_abnormal_eye_physiology1.33094143
51MP0004133_heterotaxia1.33017595
52MP0001501_abnormal_sleep_pattern1.31536630
53MP0008569_lethality_at_weaning1.31050943
54MP0001984_abnormal_olfaction1.28124983
55MP0002249_abnormal_larynx_morphology1.26869695
56MP0002638_abnormal_pupillary_reflex1.26298618
57MP0005670_abnormal_white_adipose1.25541898
58MP0001986_abnormal_taste_sensitivity1.25141029
59MP0003950_abnormal_plasma_membrane1.22099724
60MP0008058_abnormal_DNA_repair1.21031658
61MP0005386_behavior/neurological_phenoty1.20677519
62MP0004924_abnormal_behavior1.20677519
63MP0004142_abnormal_muscle_tone1.20087621
64MP0005171_absent_coat_pigmentation1.20050277
65MP0003890_abnormal_embryonic-extraembry1.19895667
66MP0008995_early_reproductive_senescence1.19345236
67MP0001963_abnormal_hearing_physiology1.17719092
68MP0005645_abnormal_hypothalamus_physiol1.17510215
69MP0002152_abnormal_brain_morphology1.17194106
70MP0001970_abnormal_pain_threshold1.16859604
71MP0002733_abnormal_thermal_nociception1.16084543
72MP0003878_abnormal_ear_physiology1.15433523
73MP0005377_hearing/vestibular/ear_phenot1.15433523
74MP0005646_abnormal_pituitary_gland1.15414559
75MP0002752_abnormal_somatic_nervous1.14420127
76MP0002233_abnormal_nose_morphology1.12883071
77MP0000955_abnormal_spinal_cord1.11634563
78MP0006276_abnormal_autonomic_nervous1.10868711
79MP0000026_abnormal_inner_ear1.08056869
80MP0000015_abnormal_ear_pigmentation1.06318728
81MP0002066_abnormal_motor_capabilities/c1.04138323
82MP0003938_abnormal_ear_development1.03624463
83MP0002938_white_spotting1.03106440
84MP0003861_abnormal_nervous_system0.99872734
85MP0001286_abnormal_eye_development0.99242391
86MP0000049_abnormal_middle_ear0.96414424
87MP0002928_abnormal_bile_duct0.95711760
88MP0005195_abnormal_posterior_eye0.95283782
89MP0002160_abnormal_reproductive_system0.94330089
90MP0002229_neurodegeneration0.91305771
91MP0004215_abnormal_myocardial_fiber0.90974235
92MP0004811_abnormal_neuron_physiology0.90663327
93MP0003567_abnormal_fetal_cardiomyocyte0.90298530
94MP0003123_paternal_imprinting0.89918395
95MP0003937_abnormal_limbs/digits/tail_de0.89530697
96MP0001299_abnormal_eye_distance/0.87778633
97MP0003385_abnormal_body_wall0.87306855
98MP0003119_abnormal_digestive_system0.85528145
99MP0010094_abnormal_chromosome_stability0.85147950
100MP0003698_abnormal_male_reproductive0.84801918
101MP0005499_abnormal_olfactory_system0.82468770
102MP0005394_taste/olfaction_phenotype0.82468770
103MP0002210_abnormal_sex_determination0.80602867
104MP0003755_abnormal_palate_morphology0.79469479
105MP0002089_abnormal_postnatal_growth/wei0.78949175
106MP0003137_abnormal_impulse_conducting0.78651845
107MP0010386_abnormal_urinary_bladder0.77981238
108MP0004043_abnormal_pH_regulation0.77387905
109MP0002822_catalepsy0.76533551
110MP0002697_abnormal_eye_size0.75886492
111MP0003942_abnormal_urinary_system0.75714800
112MP0001177_atelectasis0.73351167
113MP0008872_abnormal_physiological_respon0.72519486
114MP0001905_abnormal_dopamine_level0.72290570
115MP0000462_abnormal_digestive_system0.69917907
116MP0002082_postnatal_lethality0.68942659
117MP0010770_preweaning_lethality0.68942659
118MP0005391_vision/eye_phenotype0.67378265
119MP0002081_perinatal_lethality0.67313098
120MP0010769_abnormal_survival0.66141752
121MP0002751_abnormal_autonomic_nervous0.64451927
122MP0010768_mortality/aging0.64198053
123MP0002127_abnormal_cardiovascular_syste0.63957661
124MP0003935_abnormal_craniofacial_develop0.63604782
125MP0000428_abnormal_craniofacial_morphol0.63235541
126MP0005174_abnormal_tail_pigmentation0.63175239
127MP0009250_abnormal_appendicular_skeleto0.62301743
128MP0002116_abnormal_craniofacial_bone0.60929040

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.39084095
2Febrile seizures (HP:0002373)4.04550334
3Epileptic encephalopathy (HP:0200134)3.53091928
4Pancreatic cysts (HP:0001737)3.20790214
5Progressive cerebellar ataxia (HP:0002073)3.13409992
6Atonic seizures (HP:0010819)3.02210473
7Focal seizures (HP:0007359)3.01413557
8Broad-based gait (HP:0002136)2.88064019
9Rib fusion (HP:0000902)2.72713753
10Protruding tongue (HP:0010808)2.66593999
11Congenital primary aphakia (HP:0007707)2.63367957
12Gaze-evoked nystagmus (HP:0000640)2.60196154
13Volvulus (HP:0002580)2.58939570
14Excessive salivation (HP:0003781)2.58010211
15Drooling (HP:0002307)2.58010211
16Congenital stationary night blindness (HP:0007642)2.57663468
17Genetic anticipation (HP:0003743)2.50318053
18Cystic liver disease (HP:0006706)2.47289393
19Nephrogenic diabetes insipidus (HP:0009806)2.46867735
20Abnormal hair whorl (HP:0010721)2.46016827
21Absence seizures (HP:0002121)2.42082404
22Reticulocytopenia (HP:0001896)2.40607445
23Genital tract atresia (HP:0001827)2.39547360
24Nephronophthisis (HP:0000090)2.38238410
25Vaginal atresia (HP:0000148)2.37041738
26Tubulointerstitial nephritis (HP:0001970)2.36138821
27Chronic hepatic failure (HP:0100626)2.34256471
28Anophthalmia (HP:0000528)2.31690334
29Hemiparesis (HP:0001269)2.25256379
30Dialeptic seizures (HP:0011146)2.23534270
31Abnormality of the renal cortex (HP:0011035)2.22717926
32Poor coordination (HP:0002370)2.22332645
33Absent speech (HP:0001344)2.21927070
34Visual hallucinations (HP:0002367)2.20539985
35Dysdiadochokinesis (HP:0002075)2.16576042
36Blue irides (HP:0000635)2.15713941
37Aplasia involving bones of the upper limbs (HP:0009823)2.14356563
38Aplasia of the phalanges of the hand (HP:0009802)2.14356563
39Aplasia involving bones of the extremities (HP:0009825)2.14356563
40Action tremor (HP:0002345)2.13687207
41Hepatoblastoma (HP:0002884)2.11737128
42Sclerocornea (HP:0000647)2.11713607
43Abnormality of cells of the erythroid lineage (HP:0012130)2.10521797
44Hyperventilation (HP:0002883)2.09816057
45Postaxial foot polydactyly (HP:0001830)2.09768582
46Abnormality of the columella (HP:0009929)2.09336111
47Colon cancer (HP:0003003)2.09118604
48Long nose (HP:0003189)2.07595192
49Oligodactyly (hands) (HP:0001180)2.06801392
50Aplasia cutis congenita (HP:0001057)2.06620867
51Abnormality of the renal medulla (HP:0100957)2.02312177
52High anterior hairline (HP:0009890)2.01194295
53Anencephaly (HP:0002323)1.98706247
54Diplopia (HP:0000651)1.97633293
55Abnormality of binocular vision (HP:0011514)1.97633293
56Midline defect of the nose (HP:0004122)1.96524169
57Bile duct proliferation (HP:0001408)1.96277078
58Abnormal biliary tract physiology (HP:0012439)1.96277078
59Occipital encephalocele (HP:0002085)1.94486244
60Oligodactyly (HP:0012165)1.94036299
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.92515313
62Widely spaced teeth (HP:0000687)1.92465332
63Supernumerary spleens (HP:0009799)1.90779528
64Congenital hepatic fibrosis (HP:0002612)1.90480553
65Intestinal atresia (HP:0011100)1.89260343
66Gastroesophageal reflux (HP:0002020)1.88846520
67Molar tooth sign on MRI (HP:0002419)1.87914687
68Abnormality of midbrain morphology (HP:0002418)1.87914687
69Dysmetria (HP:0001310)1.87906804
70Postaxial hand polydactyly (HP:0001162)1.87689769
71Truncal ataxia (HP:0002078)1.86821013
72Abnormality of the ileum (HP:0001549)1.86809897
73Septo-optic dysplasia (HP:0100842)1.86617156
74Triphalangeal thumb (HP:0001199)1.85597118
75Meckel diverticulum (HP:0002245)1.85367387
76Abnormality of salivation (HP:0100755)1.84430180
77Abnormality of the diencephalon (HP:0010662)1.83324072
78Macrocytic anemia (HP:0001972)1.83244206
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83069080
80Patellar aplasia (HP:0006443)1.82561824
81Abnormality of the aortic arch (HP:0012303)1.82121507
82Absent/shortened dynein arms (HP:0200106)1.81939760
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.81939760
84Specific learning disability (HP:0001328)1.81906507
85Tubular atrophy (HP:0000092)1.81539634
86Status epilepticus (HP:0002133)1.81025914
87Inappropriate behavior (HP:0000719)1.80887487
88Abnormality of incisor morphology (HP:0011063)1.80527630
89Aganglionic megacolon (HP:0002251)1.78830726
90Myelomeningocele (HP:0002475)1.78775520
91Generalized tonic-clonic seizures (HP:0002069)1.78584095
92Cutaneous syndactyly (HP:0012725)1.78185044
93True hermaphroditism (HP:0010459)1.78060214
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.77764552
95Scanning speech (HP:0002168)1.77224771
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77187089
97Ectopic kidney (HP:0000086)1.76659008
98Aqueductal stenosis (HP:0002410)1.76228513
99Preaxial hand polydactyly (HP:0001177)1.75868810
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.75561240
101Multicystic kidney dysplasia (HP:0000003)1.75292334
102Abnormality of chromosome stability (HP:0003220)1.75262149
103Fair hair (HP:0002286)1.75217005
104Pancreatic fibrosis (HP:0100732)1.74933175
105Myokymia (HP:0002411)1.74658165
106Abnormal number of incisors (HP:0011064)1.74315143
107Abnormal number of erythroid precursors (HP:0012131)1.74180116
10811 pairs of ribs (HP:0000878)1.73753757
109Holoprosencephaly (HP:0001360)1.73557569
110Obsessive-compulsive behavior (HP:0000722)1.73537790
111Tented upper lip vermilion (HP:0010804)1.73172506
112Abnormal rod and cone electroretinograms (HP:0008323)1.72577938
113Limb dystonia (HP:0002451)1.71481036
114Highly arched eyebrow (HP:0002553)1.71432644
115Abnormal respiratory motile cilium morphology (HP:0005938)1.71209473
116Abnormal respiratory epithelium morphology (HP:0012253)1.71209473
117Abnormality of the incisor (HP:0000676)1.71156760
118Hypoplastic left heart (HP:0004383)1.70563010
119Male pseudohermaphroditism (HP:0000037)1.70387826
120Optic nerve hypoplasia (HP:0000609)1.69975664
121Medial flaring of the eyebrow (HP:0010747)1.69892468
122Type II lissencephaly (HP:0007260)1.69727466
123Autism (HP:0000717)1.67898123
124Aplasia/Hypoplasia of the patella (HP:0006498)1.67350331
125Urethral obstruction (HP:0000796)1.67092223
126Supernumerary ribs (HP:0005815)1.66188483
127Growth hormone deficiency (HP:0000824)1.66069420
128Generalized hypopigmentation of hair (HP:0011358)1.66059170
129Follicular hyperkeratosis (HP:0007502)1.65321962
130Abnormality of the labia minora (HP:0012880)1.64710458
131Optic nerve coloboma (HP:0000588)1.64570073
132Short foot (HP:0001773)1.64468050
133Gait imbalance (HP:0002141)1.64161646
134Narrow nasal bridge (HP:0000446)1.63892572
135Astigmatism (HP:0000483)1.63305616
136Hemiplegia (HP:0002301)1.63200959
137Broad alveolar ridges (HP:0000187)1.62360158
138Acute lymphatic leukemia (HP:0006721)1.62136492
139Impaired smooth pursuit (HP:0007772)1.60915495
140Cutaneous finger syndactyly (HP:0010554)1.60743339
141Trigonocephaly (HP:0000243)1.58966888
142Mixed hearing impairment (HP:0000410)1.58890711
143Ectopic anus (HP:0004397)1.58447003
144Exotropia (HP:0000577)1.58230594
145Cupped ear (HP:0000378)1.58164850
146Chromsome breakage (HP:0040012)1.58094639
147Intellectual disability, moderate (HP:0002342)1.58013351
148Anteriorly placed anus (HP:0001545)1.57450154
149Abnormal ciliary motility (HP:0012262)1.57371483
150Absent septum pellucidum (HP:0001331)1.56880291
151Wide intermamillary distance (HP:0006610)1.56483963
152Supernumerary bones of the axial skeleton (HP:0009144)1.56145651
153Abnormality of the nasolacrimal system (HP:0000614)1.56121334
154Decreased central vision (HP:0007663)1.55561732
155Scotoma (HP:0000575)1.55358115
156Abnormality of the antihelix (HP:0009738)1.54617177
157Deeply set eye (HP:0000490)1.53971340
158Abnormality of chromosome segregation (HP:0002916)1.53955663
159Hypoplastic nipples (HP:0002557)1.53263715
160Narrow forehead (HP:0000341)1.53237283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.59992234
2TNIK6.50107264
3MKNK14.13461188
4CASK3.13197399
5NTRK32.92774359
6TRIM282.71337069
7WNK32.65769702
8FRK2.44008834
9MAP2K72.30131165
10EPHA42.21580879
11PNCK2.10269309
12MAP3K42.01917437
13MAP4K21.99348165
14BRD41.97320555
15MAPK131.86563549
16SIK21.82822249
17WNK41.81428409
18PLK41.77293983
19DYRK21.74836853
20TYRO31.51926951
21MARK11.48713836
22NTRK21.37656803
23SRPK11.37613498
24PLK21.36219059
25AKT31.32612021
26CAMK1G1.30657031
27PRPF4B1.20989149
28BCR1.20843366
29CDK31.19064024
30MAPK151.17386097
31SGK21.12208512
32PINK11.10085443
33NEK21.05404364
34PRKCG1.04399963
35EPHB20.98704807
36STK160.95864369
37DYRK30.94160429
38RIPK40.93468715
39SGK10.93416941
40DYRK1A0.93122103
41YES10.91020257
42INSRR0.90597135
43CDC70.90037159
44SGK2230.87138568
45SGK4940.87138568
46ADRBK20.86154610
47SGK30.83519096
48WNK10.83299783
49MARK20.82928834
50NUAK10.82319318
51PAK30.79073357
52FES0.78896098
53MINK10.76945181
54MAP2K40.76351841
55TNK20.75727013
56WEE10.75679618
57CSNK1A1L0.75552914
58CAMKK10.74541625
59PKN10.73497996
60NEK60.73338221
61RIPK10.71563775
62ERBB30.71176951
63NME10.70626724
64CDK120.70260780
65PHKG10.69730388
66PHKG20.69730388
67CSNK1E0.68226742
68DYRK1B0.67992428
69CDK50.64594702
70STK380.64341049
71GRK10.63768691
72ICK0.63436167
73PAK60.63328292
74DMPK0.63228054
75CSNK1G20.62520773
76CAMK10.60004174
77UHMK10.59923044
78MAPK100.59693684
79CAMK2A0.59432289
80OXSR10.58954557
81CAMK1D0.56896440
82FGR0.56638950
83PASK0.55858989
84GSK3B0.54905344
85CAMK2B0.54247297
86GRK70.53847574
87MUSK0.53697499
88TAOK30.53696617
89CDK20.53662479
90SIK30.52621053
91PLK10.51691180
92KSR10.51555449
93TAF10.51548179
94ZAK0.51363518
95CAMK40.51243160
96ATM0.50719293
97CDC42BPA0.50368433
98DAPK20.49929834
99CHEK20.48119166
100FGFR20.47621469
101RPS6KA40.47314253
102IRAK20.46656496
103TGFBR10.46572577
104PRKCE0.46510596
105TEC0.46501432
106CDK10.46114013
107MAPK140.45924570
108FGFR10.45436476
109CAMKK20.44868515
110CHEK10.44848049
111BMPR1B0.44299863
112MAP3K100.44054732
113CCNB10.44025220
114PRKG10.43873051
115VRK10.43102128
116TLK10.42987859
117PRKCH0.42539801
118RPS6KA30.42416442
119PRKCB0.42384046
120PRKACB0.42152093
121MAP3K70.42052921
122PRKACA0.41640022
123MAP3K130.41574816
124PRKDC0.41260016
125CSNK2A20.40432575
126PLK30.39886268
127CSNK1A10.39724468
128BMPR20.39155110
129CSNK1G30.38781799
130ATR0.37637573
131PIK3CA0.37338541
132CSNK1G10.36881707
133CLK10.36281746
134CDK190.35745030
135MAPK80.35317065
136STK110.34865449
137CSNK1D0.33700160
138STK390.33460030
139CDK90.33156644

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23678777
2Ribosome_Homo sapiens_hsa030103.04455964
3Glutamatergic synapse_Homo sapiens_hsa047242.70157550
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68322036
5Phototransduction_Homo sapiens_hsa047442.54107941
6Homologous recombination_Homo sapiens_hsa034402.51825007
7Circadian entrainment_Homo sapiens_hsa047132.43886364
8Morphine addiction_Homo sapiens_hsa050322.36370580
9GABAergic synapse_Homo sapiens_hsa047272.31120703
10Long-term potentiation_Homo sapiens_hsa047202.29973546
11Taste transduction_Homo sapiens_hsa047422.04947662
12Olfactory transduction_Homo sapiens_hsa047401.98797019
13Amphetamine addiction_Homo sapiens_hsa050311.93568813
14Long-term depression_Homo sapiens_hsa047301.84616119
15Salivary secretion_Homo sapiens_hsa049701.80492649
16Serotonergic synapse_Homo sapiens_hsa047261.77917931
17Synaptic vesicle cycle_Homo sapiens_hsa047211.77006159
18Dopaminergic synapse_Homo sapiens_hsa047281.75160463
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72653232
20Oxidative phosphorylation_Homo sapiens_hsa001901.62276162
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60985747
22Mismatch repair_Homo sapiens_hsa034301.59800125
23Calcium signaling pathway_Homo sapiens_hsa040201.57740915
24Insulin secretion_Homo sapiens_hsa049111.55504967
25Renin secretion_Homo sapiens_hsa049241.54900385
26Base excision repair_Homo sapiens_hsa034101.51973849
27Non-homologous end-joining_Homo sapiens_hsa034501.51635866
28Parkinsons disease_Homo sapiens_hsa050121.48048331
29Cholinergic synapse_Homo sapiens_hsa047251.47189238
30Linoleic acid metabolism_Homo sapiens_hsa005911.46559497
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41311207
32Axon guidance_Homo sapiens_hsa043601.40417964
33Basal transcription factors_Homo sapiens_hsa030221.39968165
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39667946
35Cocaine addiction_Homo sapiens_hsa050301.37103370
36Butanoate metabolism_Homo sapiens_hsa006501.35745869
37Oxytocin signaling pathway_Homo sapiens_hsa049211.34897143
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32229372
39Gastric acid secretion_Homo sapiens_hsa049711.31087966
40cAMP signaling pathway_Homo sapiens_hsa040241.25586675
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24403479
42Protein export_Homo sapiens_hsa030601.24396879
43DNA replication_Homo sapiens_hsa030301.23689178
44RNA polymerase_Homo sapiens_hsa030201.23682137
45Nucleotide excision repair_Homo sapiens_hsa034201.20871196
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18030117
47GnRH signaling pathway_Homo sapiens_hsa049121.14379671
48Circadian rhythm_Homo sapiens_hsa047101.14363777
49mRNA surveillance pathway_Homo sapiens_hsa030151.14082556
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12811068
51Wnt signaling pathway_Homo sapiens_hsa043101.11869468
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11837037
53Huntingtons disease_Homo sapiens_hsa050161.07726755
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07239078
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05871462
56RNA transport_Homo sapiens_hsa030131.04173529
57Basal cell carcinoma_Homo sapiens_hsa052171.02156401
58Melanogenesis_Homo sapiens_hsa049161.01915864
59ErbB signaling pathway_Homo sapiens_hsa040121.01510390
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.01144272
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.99905530
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99176507
63Gap junction_Homo sapiens_hsa045400.97919820
64Dilated cardiomyopathy_Homo sapiens_hsa054140.96913422
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96086018
66Fanconi anemia pathway_Homo sapiens_hsa034600.93860288
67Propanoate metabolism_Homo sapiens_hsa006400.92863523
68Type II diabetes mellitus_Homo sapiens_hsa049300.92732823
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92324436
70Glioma_Homo sapiens_hsa052140.90017180
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88371587
72Dorso-ventral axis formation_Homo sapiens_hsa043200.88213515
73Alzheimers disease_Homo sapiens_hsa050100.86808027
74Alcoholism_Homo sapiens_hsa050340.85277560
75MAPK signaling pathway_Homo sapiens_hsa040100.84534403
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83846756
77Pancreatic secretion_Homo sapiens_hsa049720.83381518
78Melanoma_Homo sapiens_hsa052180.83067087
79Oocyte meiosis_Homo sapiens_hsa041140.81153452
80Lysine degradation_Homo sapiens_hsa003100.79673407
81Selenocompound metabolism_Homo sapiens_hsa004500.78671442
82Hedgehog signaling pathway_Homo sapiens_hsa043400.77823818
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.77440579
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76984870
85Choline metabolism in cancer_Homo sapiens_hsa052310.75914757
86Nitrogen metabolism_Homo sapiens_hsa009100.74282616
87Ras signaling pathway_Homo sapiens_hsa040140.74220850
88Estrogen signaling pathway_Homo sapiens_hsa049150.74051464
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73270808
90Regulation of autophagy_Homo sapiens_hsa041400.71685023
91Inositol phosphate metabolism_Homo sapiens_hsa005620.68765359
92Purine metabolism_Homo sapiens_hsa002300.67714534
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64757356
94Spliceosome_Homo sapiens_hsa030400.64591514
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64471957
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63416703
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63154688
98Cardiac muscle contraction_Homo sapiens_hsa042600.61825040
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60410861
100Rap1 signaling pathway_Homo sapiens_hsa040150.59448976
101One carbon pool by folate_Homo sapiens_hsa006700.59420996
102mTOR signaling pathway_Homo sapiens_hsa041500.58370342
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56460517
104Ovarian steroidogenesis_Homo sapiens_hsa049130.56261348
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56003710
106Steroid biosynthesis_Homo sapiens_hsa001000.54630009
107Ether lipid metabolism_Homo sapiens_hsa005650.54157435
108Peroxisome_Homo sapiens_hsa041460.53935556
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53080032
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52841315
111Glycerolipid metabolism_Homo sapiens_hsa005610.51805072
112Colorectal cancer_Homo sapiens_hsa052100.50542734
113Endometrial cancer_Homo sapiens_hsa052130.50077920
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49744208
115Renal cell carcinoma_Homo sapiens_hsa052110.49576630
116Notch signaling pathway_Homo sapiens_hsa043300.49012223
117Collecting duct acid secretion_Homo sapiens_hsa049660.48874326
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48869973
119Thyroid hormone synthesis_Homo sapiens_hsa049180.48556335
120MicroRNAs in cancer_Homo sapiens_hsa052060.48373836
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.46908149
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46888213
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46566055
124Prostate cancer_Homo sapiens_hsa052150.45728186
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45563431
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43827088
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43732305
128ABC transporters_Homo sapiens_hsa020100.43577080
129Non-small cell lung cancer_Homo sapiens_hsa052230.43459322
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.43180413
131Cell cycle_Homo sapiens_hsa041100.41260720
132Pathways in cancer_Homo sapiens_hsa052000.41075406
133RNA degradation_Homo sapiens_hsa030180.40941257
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39675879
135Autoimmune thyroid disease_Homo sapiens_hsa053200.39291482
136Pyrimidine metabolism_Homo sapiens_hsa002400.38588667
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37911188
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37455620
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37170423
140Hippo signaling pathway_Homo sapiens_hsa043900.36517136
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35687340
142Chemokine signaling pathway_Homo sapiens_hsa040620.35151395

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