LUM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)8.07131915
2protein heterotrimerization (GO:0070208)7.72036742
3* collagen fibril organization (GO:0030199)6.88776533
4cell migration involved in heart development (GO:0060973)6.51985268
5* keratan sulfate catabolic process (GO:0042340)6.50420635
6mesenchymal-epithelial cell signaling (GO:0060638)6.36548637
7collagen catabolic process (GO:0030574)5.85683188
8collagen metabolic process (GO:0032963)5.82338547
9dermatan sulfate biosynthetic process (GO:0030208)5.54039399
10multicellular organismal macromolecule metabolic process (GO:0044259)5.48239142
11multicellular organismal catabolic process (GO:0044243)5.40747451
12extracellular fibril organization (GO:0043206)5.39798563
13bone trabecula formation (GO:0060346)5.38030503
14multicellular organismal metabolic process (GO:0044236)5.22654691
15cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.19645022
16dermatan sulfate metabolic process (GO:0030205)5.05595482
17regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.84978478
18extracellular matrix disassembly (GO:0022617)4.77813615
19chondrocyte development (GO:0002063)4.75842218
20fibril organization (GO:0097435)4.52407218
21cell aggregation (GO:0098743)4.44687075
22cartilage condensation (GO:0001502)4.44687075
23protein retention in ER lumen (GO:0006621)4.37429229
24sequestering of extracellular ligand from receptor (GO:0035581)4.26667553
25endodermal cell differentiation (GO:0035987)4.20750660
26cochlea morphogenesis (GO:0090103)4.19105287
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.16981566
28chondrocyte proliferation (GO:0035988)4.10107867
29endocardial cushion development (GO:0003197)3.99885665
30mesenchyme morphogenesis (GO:0072132)3.94703007
31endocardial cushion morphogenesis (GO:0003203)3.90082738
32glomerular basement membrane development (GO:0032836)3.88696361
33* extracellular matrix organization (GO:0030198)3.82003809
34substrate-dependent cell migration (GO:0006929)3.81908433
35* extracellular structure organization (GO:0043062)3.80395881
36chondroitin sulfate catabolic process (GO:0030207)3.75086346
37negative regulation of chondrocyte differentiation (GO:0032331)3.74610876
38notochord development (GO:0030903)3.74440555
39chondroitin sulfate biosynthetic process (GO:0030206)3.71726392
40glomerular filtration (GO:0003094)3.70812618
41protein localization to cell surface (GO:0034394)3.68734103
42pericardium development (GO:0060039)3.61326035
43tooth mineralization (GO:0034505)3.55103004
44blood vessel maturation (GO:0001955)3.54489592
45endothelial cell morphogenesis (GO:0001886)3.54476104
46smooth muscle tissue development (GO:0048745)3.54083682
47outer ear morphogenesis (GO:0042473)3.53981897
48regulation of extracellular matrix disassembly (GO:0010715)3.52352665
49lymph vessel development (GO:0001945)3.51144281
50retina vasculature morphogenesis in camera-type eye (GO:0061299)3.49295503
51negative regulation of protein activation cascade (GO:2000258)3.46930452
52skin morphogenesis (GO:0043589)3.45546348
53regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38352367
54negative regulation of cartilage development (GO:0061037)3.37935992
55renal filtration (GO:0097205)3.34134106
56embryonic skeletal joint morphogenesis (GO:0060272)3.33525648
57peptidyl-proline hydroxylation (GO:0019511)3.32860846
58basement membrane organization (GO:0071711)3.32207196
59regulation of cardioblast differentiation (GO:0051890)3.31299075
60embryonic cranial skeleton morphogenesis (GO:0048701)3.30518532
61regulation of integrin-mediated signaling pathway (GO:2001044)3.28131872
62virion attachment to host cell (GO:0019062)3.27208784
63adhesion of symbiont to host cell (GO:0044650)3.27208784
64regulation of organ formation (GO:0003156)3.25036481
65face morphogenesis (GO:0060325)3.22717040
66establishment of planar polarity (GO:0001736)3.21695395
67establishment of tissue polarity (GO:0007164)3.21695395
68cell proliferation involved in kidney development (GO:0072111)3.21587779
69positive regulation of osteoblast proliferation (GO:0033690)3.20726388
70positive regulation of mesenchymal cell proliferation (GO:0002053)3.17981822
71planar cell polarity pathway involved in neural tube closure (GO:0090179)3.16315530
72regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.13994789
73cell adhesion mediated by integrin (GO:0033627)3.13060791
74neuron projection extension involved in neuron projection guidance (GO:1902284)3.12554459
75axon extension involved in axon guidance (GO:0048846)3.12554459
76regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.12004635
77positive regulation of extracellular matrix organization (GO:1903055)3.11268431
78iron ion import (GO:0097286)3.09813774
79* glycosaminoglycan catabolic process (GO:0006027)3.08922220
80* cartilage development (GO:0051216)3.07021462
81regulation of biomineral tissue development (GO:0070167)3.05835201
82metanephric mesenchyme development (GO:0072075)3.04376610
83extracellular matrix assembly (GO:0085029)3.03047990
84biomineral tissue development (GO:0031214)3.02791424
85complement activation, classical pathway (GO:0006958)3.02644907
86extracellular negative regulation of signal transduction (GO:1900116)3.02236867
87extracellular regulation of signal transduction (GO:1900115)3.02236867
88protein trimerization (GO:0070206)3.00782813
89regulation of macrophage cytokine production (GO:0010935)3.00479697
90regulation of cardioblast proliferation (GO:0003264)3.00442142
91regulation of secondary heart field cardioblast proliferation (GO:0003266)3.00442142
92opsonization (GO:0008228)3.00281027
93response to BMP (GO:0071772)3.00041449
94cellular response to BMP stimulus (GO:0071773)3.00041449
95atrioventricular valve morphogenesis (GO:0003181)3.00033766
96regulation of bone mineralization (GO:0030500)2.98969201
97ossification (GO:0001503)2.98251124
98negative regulation of complement activation (GO:0045916)2.97313218
99nucleotide-sugar biosynthetic process (GO:0009226)2.96953200
100pathway-restricted SMAD protein phosphorylation (GO:0060389)2.96259503
101regulation of mesenchymal cell proliferation (GO:0010464)2.96227204
102* sulfur compound catabolic process (GO:0044273)2.95916347
103negative regulation of glycogen biosynthetic process (GO:0045719)2.95346210
104positive regulation of respiratory burst (GO:0060267)2.95244896
105Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.95179356
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94576973
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94533020
108organ induction (GO:0001759)2.94152122
109mesenchymal cell proliferation (GO:0010463)2.91362609
110regulation of chondrocyte differentiation (GO:0032330)2.91232067
111positive regulation of macrophage cytokine production (GO:0060907)2.90268654
112non-canonical Wnt signaling pathway (GO:0035567)2.90025053
113regulation of cartilage development (GO:0061035)2.89897778
114positive regulation of cartilage development (GO:0061036)2.89098285
115negative regulation of BMP signaling pathway (GO:0030514)2.88354030
116negative regulation of biomineral tissue development (GO:0070168)2.88046263
117negative regulation of heart growth (GO:0061117)2.88035472
118negative regulation of cardiac muscle tissue growth (GO:0055022)2.88035472
119negative regulation of catenin import into nucleus (GO:0035414)2.87504711
120type B pancreatic cell proliferation (GO:0044342)2.87257588
121platelet-derived growth factor receptor signaling pathway (GO:0048008)2.86421115
122* aminoglycan catabolic process (GO:0006026)2.86374913
123skeletal system development (GO:0001501)2.85624683
124cell proliferation involved in metanephros development (GO:0072203)2.84716062
125positive regulation of glycogen biosynthetic process (GO:0045725)2.84619717
126wound healing, spreading of epidermal cells (GO:0035313)2.83729393
127negative regulation of humoral immune response (GO:0002921)2.83122473
128regulation of establishment of planar polarity (GO:0090175)2.82866156
129positive regulation of epithelial to mesenchymal transition (GO:0010718)2.82455091
130* keratan sulfate biosynthetic process (GO:0018146)2.82305398
131kidney mesenchyme development (GO:0072074)2.81767227
132craniofacial suture morphogenesis (GO:0097094)2.80311072
133bone mineralization (GO:0030282)2.79472017
134cellular response to amino acid stimulus (GO:0071230)2.79181502
135chondroitin sulfate metabolic process (GO:0030204)2.78800701
136* glycosaminoglycan biosynthetic process (GO:0006024)2.78518675
137adhesion of symbiont to host (GO:0044406)2.77951951
138middle ear morphogenesis (GO:0042474)2.76819593
139peptide cross-linking (GO:0018149)2.76189680
140negative regulation of fatty acid transport (GO:2000192)2.75319637
141negative regulation of cardiac muscle tissue development (GO:0055026)2.74953813
142trivalent inorganic anion homeostasis (GO:0072506)2.74677096
143phosphate ion homeostasis (GO:0055062)2.74677096
144surfactant homeostasis (GO:0043129)2.72645226
145vascular endothelial growth factor signaling pathway (GO:0038084)2.70372575
146protein hydroxylation (GO:0018126)2.65476434
147endochondral ossification (GO:0001958)2.64885235
148replacement ossification (GO:0036075)2.64885235
149negative regulation of smooth muscle cell migration (GO:0014912)2.64386487
150substrate adhesion-dependent cell spreading (GO:0034446)2.64265757
151regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59246800
152regulation of odontogenesis (GO:0042481)2.59038768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRIM28_21343339_ChIP-Seq_HEK293_Human6.67469368
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.02046304
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.48305890
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.31082548
5AR_21572438_ChIP-Seq_LNCaP_Human3.08105927
6* ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.01587673
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.68683977
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.62837027
9CLOCK_20551151_ChIP-Seq_293T_Human2.59398399
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.54355319
11CJUN_26792858_Chip-Seq_BT549_Human2.46830547
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.41323475
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24989781
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.21981118
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12149152
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11364470
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11364470
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05348270
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95960572
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92025252
21TP53_18474530_ChIP-ChIP_U2OS_Human1.91340038
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.88843165
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87858809
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.87707807
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81277470
26* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80867671
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76864314
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76695046
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.74619799
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.74619799
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73451933
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.73234674
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69274490
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66993584
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66631639
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.65288515
37TP53_16413492_ChIP-PET_HCT116_Human1.65268173
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63768128
39GATA1_22025678_ChIP-Seq_K562_Human1.62432645
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.61427387
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.60657459
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57602487
43* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56005757
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53117733
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51166632
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50758056
47* BRD4_25478319_ChIP-Seq_HGPS_Human1.50711015
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45243212
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45057795
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44585992
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43766417
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41034673
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35641572
54SOX2_20726797_ChIP-Seq_SW620_Human1.35111573
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.34532360
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34263922
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.33750980
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33157323
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28422871
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.27848539
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27318151
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17588901
63BCAT_22108803_ChIP-Seq_LS180_Human1.16127476
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.15613799
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15526037
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15302875
67VDR_24787735_ChIP-Seq_THP-1_Human1.12501223
68* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10981476
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.09488406
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.09444955
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09136932
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08530980
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08460266
74SMAD4_21799915_ChIP-Seq_A2780_Human1.07738841
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.05500562
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04966910
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04946514
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04854222
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03071887
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02663259
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02412329
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02148703
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.01860849
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01460545
85GBX2_23144817_ChIP-Seq_PC3_Human1.00323598
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99854950
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98685021
88DROSHA_22980978_ChIP-Seq_HELA_Human0.98406715
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98140566
90SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97344236
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97172061
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96281299
93TCF4_18268006_ChIP-ChIP_LS174T_Human0.96177151
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96079176
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.96023103
96NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95775325
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.95436211
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94663993
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94263204
100KDM2B_26808549_Chip-Seq_REH_Human0.93982548
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93898082
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93673653
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93567980
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.93342550
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93328445
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92129937
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92129937
108* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92122960
109RING1B_27294783_Chip-Seq_ESCs_Mouse0.91784272
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90696154
111TBX20_22080862_ChIP-Seq_HEART_Mouse0.90089342
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.90089342
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89566988
114RXR_22108803_ChIP-Seq_LS180_Human0.89411571
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89257948
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.88313612
117* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87594860
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86275110
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84514914
120TP63_23658742_ChIP-Seq_EP156T_Human0.83731997
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.83496508
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82389545
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81997655
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81691587
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.79789230
126AHR_22903824_ChIP-Seq_MCF-7_Human0.79499049
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.78811606
128SA1_22415368_ChIP-Seq_MEFs_Mouse0.78514385
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.77385203
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.77273864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.33319639
2* MP0005503_abnormal_tendon_morphology7.49306211
3* MP0005275_abnormal_skin_tensile5.90511218
4MP0006054_spinal_hemorrhage3.26606195
5MP0004272_abnormal_basement_membrane3.08235398
6MP0001958_emphysema2.68173032
7* MP0005508_abnormal_skeleton_morphology2.67900492
8MP0001542_abnormal_bone_strength2.50445953
9MP0003279_aneurysm2.44113731
10* MP0002108_abnormal_muscle_morphology2.35270073
11MP0003705_abnormal_hypodermis_morpholog2.34580820
12MP0002933_joint_inflammation2.24610527
13MP0002060_abnormal_skin_morphology2.21584953
14MP0010368_abnormal_lymphatic_system2.20101914
15MP0009250_abnormal_appendicular_skeleto2.19837173
16MP0002282_abnormal_trachea_morphology2.07683783
17MP0004134_abnormal_chest_morphology2.02662327
18MP0000163_abnormal_cartilage_morphology1.99389687
19MP0002896_abnormal_bone_mineralization1.90503422
20MP0002115_abnormal_skeleton_extremities1.73501935
21* MP0005390_skeleton_phenotype1.70782897
22MP0000751_myopathy1.66671744
23MP0009780_abnormal_chondrocyte_physiolo1.57990551
24MP0003385_abnormal_body_wall1.57593582
25MP0003950_abnormal_plasma_membrane1.55778865
26MP0002113_abnormal_skeleton_development1.54508737
27MP0001879_abnormal_lymphatic_vessel1.53996855
28MP0002998_abnormal_bone_remodeling1.50635641
29MP0009384_cardiac_valve_regurgitation1.48006913
30MP0003566_abnormal_cell_adhesion1.46447070
31MP0003195_calcinosis1.40557600
32MP0002254_reproductive_system_inflammat1.37169369
33* MP0001243_abnormal_dermal_layer1.32776193
34MP0002249_abnormal_larynx_morphology1.32359413
35MP0000049_abnormal_middle_ear1.30880552
36MP0000762_abnormal_tongue_morphology1.30523243
37MP0001533_abnormal_skeleton_physiology1.27321539
38MP0010352_gastrointestinal_tract_polyps1.26770774
39MP0002089_abnormal_postnatal_growth/wei1.26678900
40* MP0005023_abnormal_wound_healing1.26676959
41MP0003795_abnormal_bone_structure1.21740103
42MP0010030_abnormal_orbit_morphology1.20202050
43MP0002295_abnormal_pulmonary_circulatio1.18907155
44MP0002932_abnormal_joint_morphology1.16459426
45MP0002116_abnormal_craniofacial_bone1.16385246
46MP0005257_abnormal_intraocular_pressure1.15235259
47MP0001348_abnormal_lacrimal_gland1.14710198
48MP0000534_abnormal_ureter_morphology1.14628662
49MP0003122_maternal_imprinting1.14244122
50MP0000767_abnormal_smooth_muscle1.09732008
51MP0002109_abnormal_limb_morphology1.09215555
52MP0003942_abnormal_urinary_system1.08939137
53MP0004883_abnormal_blood_vessel1.06052107
54MP0000462_abnormal_digestive_system1.04919918
55MP0000432_abnormal_head_morphology0.99430581
56MP0003755_abnormal_palate_morphology0.98865155
57MP0003941_abnormal_skin_development0.97551192
58MP0005171_absent_coat_pigmentation0.95755905
59MP0005623_abnormal_meninges_morphology0.95334254
60MP0001299_abnormal_eye_distance/0.91981835
61MP0003115_abnormal_respiratory_system0.91313780
62MP0003011_delayed_dark_adaptation0.89593907
63MP0003283_abnormal_digestive_organ0.87438328
64MP0002233_abnormal_nose_morphology0.86835224
65MP0000428_abnormal_craniofacial_morphol0.85963488
66MP0001270_distended_abdomen0.85382969
67MP0000733_abnormal_muscle_development0.85379993
68MP0000537_abnormal_urethra_morphology0.85284787
69MP0000613_abnormal_salivary_gland0.84166514
70MP0005248_abnormal_Harderian_gland0.80727118
71MP0003935_abnormal_craniofacial_develop0.80221417
72MP0009053_abnormal_anal_canal0.79010360
73MP0003123_paternal_imprinting0.78729701
74MP0002114_abnormal_axial_skeleton0.77826060
75MP0000003_abnormal_adipose_tissue0.75625871
76MP0005164_abnormal_response_to0.75604554
77MP0000013_abnormal_adipose_tissue0.74119751
78MP0005367_renal/urinary_system_phenotyp0.74032692
79MP0000516_abnormal_urinary_system0.74032692
80MP0003252_abnormal_bile_duct0.73608057
81MP0000343_altered_response_to0.73080686
82MP0002938_white_spotting0.72645495
83MP0004185_abnormal_adipocyte_glucose0.71634521
84* MP0005369_muscle_phenotype0.69607715
85MP0001175_abnormal_lung_morphology0.68205202
86MP0008004_abnormal_stomach_pH0.66993884
87MP0002111_abnormal_tail_morphology0.65823505
88MP0003091_abnormal_cell_migration0.65626046
89MP0002168_other_aberrant_phenotype0.63957374
90MP0002876_abnormal_thyroid_physiology0.63850360
91MP0010771_integument_phenotype0.61374222
92MP0005165_increased_susceptibility_to0.61194678
93MP0002133_abnormal_respiratory_system0.61123641
94MP0005388_respiratory_system_phenotype0.61123641
95MP0003448_altered_tumor_morphology0.59935507
96MP0000750_abnormal_muscle_regeneration0.58676560
97MP0005197_abnormal_uvea_morphology0.57279697
98MP0001614_abnormal_blood_vessel0.56910340
99MP0000604_amyloidosis0.55574043
100* MP0002128_abnormal_blood_circulation0.55503203
101MP0000681_abnormal_thyroid_gland0.55234605
102MP0005595_abnormal_vascular_smooth0.54326237
103MP0004084_abnormal_cardiac_muscle0.53905663
104MP0000538_abnormal_urinary_bladder0.53765143
105MP0010386_abnormal_urinary_bladder0.52866942
106MP0001177_atelectasis0.52817194
107MP0002837_dystrophic_cardiac_calcinosis0.51351793
108MP0002102_abnormal_ear_morphology0.50632925
109MP0003937_abnormal_limbs/digits/tail_de0.50608790
110MP0003567_abnormal_fetal_cardiomyocyte0.49040177
111MP0003300_gastrointestinal_ulcer0.48506002
112MP0005375_adipose_tissue_phenotype0.47699540
113MP0000749_muscle_degeneration0.47544516
114MP0004484_altered_response_of0.47324436
115MP0000249_abnormal_blood_vessel0.47147580
116* MP0005193_abnormal_anterior_eye0.45338055
117MP0004858_abnormal_nervous_system0.41787324
118MP0001661_extended_life_span0.41733732

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.77723130
2Premature rupture of membranes (HP:0001788)5.96997207
3Epiphyseal dysplasia (HP:0002656)5.57708130
4Neonatal short-limb short stature (HP:0008921)5.29220740
5Broad metatarsal (HP:0001783)4.43866852
6Vitreoretinal degeneration (HP:0000655)4.32135878
7Irregular epiphyses (HP:0010582)4.30518584
8Aortic dissection (HP:0002647)4.29130893
9Ankle contracture (HP:0006466)4.26003799
10Biconcave vertebral bodies (HP:0004586)4.17666983
11Mild short stature (HP:0003502)4.14127453
12Hypoplastic ischia (HP:0003175)4.11934971
13Follicular hyperkeratosis (HP:0007502)4.08434358
14Cervical subluxation (HP:0003308)4.01045505
15Soft skin (HP:0000977)3.94494476
16Abnormality of the frontal sinuses (HP:0002687)3.69513321
17Wormian bones (HP:0002645)3.63603934
18Abnormality of the ischium (HP:0003174)3.62845910
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.61203628
20Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.56783708
21Osteoarthritis (HP:0002758)3.55731583
22Small epiphyses (HP:0010585)3.55316951
23Cupped ribs (HP:0000887)3.46895978
24Shallow orbits (HP:0000586)3.39947381
25Atrophic scars (HP:0001075)3.38914042
26Abnormality of dentin (HP:0010299)3.25761637
27Bladder diverticulum (HP:0000015)3.15386482
28Persistence of primary teeth (HP:0006335)3.13779810
29Blue sclerae (HP:0000592)3.13488724
30Type 1 muscle fiber predominance (HP:0003803)3.08340478
31Platyspondyly (HP:0000926)3.05511404
32Aortic aneurysm (HP:0004942)2.93334631
33Spondylolisthesis (HP:0003302)2.90621613
34Metaphyseal cupping (HP:0003021)2.85372292
35Delayed cranial suture closure (HP:0000270)2.85311174
36Abnormal tarsal ossification (HP:0008369)2.84689722
37Mitral valve prolapse (HP:0001634)2.82623853
38Hip contracture (HP:0003273)2.80383068
39Fragile skin (HP:0001030)2.80215589
40Partial duplication of the phalanx of hand (HP:0009999)2.74304663
41Tibial bowing (HP:0002982)2.65654737
42Limited hip movement (HP:0008800)2.63925595
43Vertebral compression fractures (HP:0002953)2.59224658
44Slender build (HP:0001533)2.58599844
45Genu varum (HP:0002970)2.54126070
46Delayed epiphyseal ossification (HP:0002663)2.53444239
47Absent frontal sinuses (HP:0002688)2.52894283
48Short middle phalanx of the 5th finger (HP:0004220)2.52686451
49Spinal rigidity (HP:0003306)2.51812065
50Bowel diverticulosis (HP:0005222)2.50032531
51Coxa vara (HP:0002812)2.47005043
52Nonimmune hydrops fetalis (HP:0001790)2.46954534
53Cerebral aneurysm (HP:0004944)2.46460190
54Overgrowth (HP:0001548)2.46412693
55Abnormality of the acetabulum (HP:0003170)2.45197963
56Keratoconus (HP:0000563)2.41162866
57Increased corneal curvature (HP:0100692)2.41162866
58Dilatation of the ascending aorta (HP:0005111)2.39871712
59Asymmetry of the thorax (HP:0001555)2.39199903
60Systemic lupus erythematosus (HP:0002725)2.38064584
61Breech presentation (HP:0001623)2.37401976
62Vascular tortuosity (HP:0004948)2.36767039
63Wide anterior fontanel (HP:0000260)2.36467903
64Flattened epiphyses (HP:0003071)2.35387320
65Hyperextensible skin (HP:0000974)2.34663163
66Wrist flexion contracture (HP:0001239)2.33478382
67Absent epiphyses (HP:0010577)2.32777271
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.32777271
69Infantile muscular hypotonia (HP:0008947)2.32435434
70Arterial tortuosity (HP:0005116)2.30625730
71Abnormality of the vertebral endplates (HP:0005106)2.30527861
72Genu recurvatum (HP:0002816)2.30486155
73Mesomelia (HP:0003027)2.28415140
74Pulmonary artery stenosis (HP:0004415)2.27786504
75Osteolytic defects of the hand bones (HP:0009699)2.26114397
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.26114397
77Aplasia of the musculature (HP:0100854)2.24925904
78Joint laxity (HP:0001388)2.22493808
79Beaking of vertebral bodies (HP:0004568)2.22170035
80Flared iliac wings (HP:0002869)2.21936992
81Striae distensae (HP:0001065)2.21460420
82Ectopia lentis (HP:0001083)2.19507427
83Abnormal delivery (HP:0001787)2.19191103
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18040599
85Broad ribs (HP:0000885)2.17953975
86Metaphyseal dysplasia (HP:0100255)2.17537541
87Narrow palate (HP:0000189)2.16886362
88Severe Myopia (HP:0011003)2.16427311
89Broad long bones (HP:0005622)2.15095065
90Aneurysm (HP:0002617)2.14045988
91Abnormal foot bone ossification (HP:0010675)2.13597225
92Exostoses (HP:0100777)2.11298901
93Peritonitis (HP:0002586)2.11005106
94Hypoplasia of the iris (HP:0007676)2.09963910
95Abnormality of skull ossification (HP:0002703)2.08986690
96Dislocated radial head (HP:0003083)2.08895011
97Mitral stenosis (HP:0001718)2.08569726
98Disproportionate tall stature (HP:0001519)2.06377959
99Thoracolumbar scoliosis (HP:0002944)2.05544384
100Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03674178
101Bell-shaped thorax (HP:0001591)2.03528467
102Ovoid vertebral bodies (HP:0003300)2.03313828
103Enlarged epiphyses (HP:0010580)2.02878259
104Flat capital femoral epiphysis (HP:0003370)2.02698460
105Increased connective tissue (HP:0009025)2.02458774
106Cardiovascular calcification (HP:0011915)2.02386854
107Radial bowing (HP:0002986)1.99689854
108Decreased skull ossification (HP:0004331)1.99302796
109Abnormality of complement system (HP:0005339)1.98518634
110Aortic regurgitation (HP:0001659)1.98097907
111Flat acetabular roof (HP:0003180)1.97725178
112Irregular vertebral endplates (HP:0003301)1.97471003
113Ulnar bowing (HP:0003031)1.97085299
114Coronal craniosynostosis (HP:0004440)1.96617204
115Abnormality of the radial head (HP:0003995)1.94710531
116Delayed closure of the anterior fontanelle (HP:0001476)1.94399124
117Hypophosphatemic rickets (HP:0004912)1.94383576
118Abnormality of femoral epiphyses (HP:0006499)1.92770675
119Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.92770675
120Long clavicles (HP:0000890)1.91297678
121Abnormality of the pubic bones (HP:0003172)1.90583539
122Alopecia of scalp (HP:0002293)1.89944712
123Osteopenia (HP:0000938)1.89344426
124Abnormality of incisor morphology (HP:0011063)1.89131821
125Abnormality of carpal bone ossification (HP:0006257)1.88454244
126Mildly elevated creatine phosphokinase (HP:0008180)1.88002393
127Aortic valve stenosis (HP:0001650)1.86148092
128Abnormality of the 2nd finger (HP:0004100)1.85894326
129Partial duplication of thumb phalanx (HP:0009944)1.84162258
130Femoral bowing (HP:0002980)1.83793057
131Abnormality of primary teeth (HP:0006481)1.83263549
132Broad phalanx (HP:0006009)1.83205695
133Morphological abnormality of the middle ear (HP:0008609)1.82891499
134Syringomyelia (HP:0003396)1.81733516
135Spinal cord lesions (HP:0100561)1.81733516
136Deviation of the hallux (HP:0010051)1.80877978
137Hallux valgus (HP:0001822)1.80421821
138Arthropathy (HP:0003040)1.77665199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.69526678
2PDGFRA3.53447977
3INSRR3.08675948
4EPHB23.03569979
5EPHA33.01410039
6TYK22.93510387
7LATS12.75684227
8TGFBR22.70900727
9TRPM72.66312554
10NME22.51317018
11ERBB32.23948529
12STK38L2.20825864
13TTN2.20442253
14MAP3K122.12461721
15SIK12.04436800
16MET1.95422326
17AKT31.93066988
18CDC42BPA1.87654022
19FER1.87627882
20TRIB31.79575247
21ZAK1.77200398
22FRK1.75798137
23ERN11.75758621
24MYLK1.72643204
25MAP3K31.66500029
26SCYL21.57830545
27STK31.55679723
28PAK21.46122068
29LATS21.45815552
30TNIK1.38428211
31STK241.36866732
32PIK3CG1.28868514
33PLK21.25195429
34PDGFRB1.24551772
35DMPK1.21943530
36PIK3CA1.20682484
37NTRK11.13904120
38PIM21.12855052
39PRKG21.05408429
40STK380.98695586
41PTK20.97728622
42FLT30.94276494
43NEK60.93570839
44ROCK10.91523354
45MST1R0.89646966
46PAK30.87548949
47WNK10.85410730
48ABL20.84649873
49TNK20.84387357
50GRK10.80135103
51GRK70.79478871
52ADRBK20.75825537
53PTK60.75479925
54PRKD20.74852818
55BCR0.73613724
56TIE10.73448741
57BMX0.72087151
58EPHB10.71621830
59JAK10.70165367
60GRK50.68809934
61PRKCH0.67389271
62FGFR10.67116579
63STK390.66898668
64GSK3A0.65024519
65PRKCE0.64679646
66NUAK10.63706024
67RET0.60905631
68ADRBK10.60573870
69ILK0.60293212
70PKN20.59174960
71MAP3K20.58835718
72CAMK1G0.57982231
73CSK0.57867421
74RIPK10.57246131
75LRRK20.56537519
76BCKDK0.56232486
77MAP3K60.55308012
78SGK30.54999902
79TGFBR10.54265693
80ABL10.54027891
81CAMK1D0.52492372
82FGFR30.51116625
83PTK2B0.49589366
84KSR10.49179857
85LMTK20.48635809
86CDK60.48423683
87MELK0.47129093
88IGF1R0.45484150
89PAK40.44750394
90MAPKAPK50.44099310
91FGFR20.44012795
92CAMK2G0.42473798
93MAP2K10.41516930
94PLK30.41120289
95RAF10.40749409
96NLK0.39900303
97ROCK20.39451956
98MAPK120.39264590
99MAPK70.37627292
100INSR0.37554388
101TESK10.37116997
102FGFR40.37107451
103MAP3K70.36880471
104SGK20.36854670
105PRKD10.36782965
106PAK60.36635929
107EIF2AK30.35586247
108OBSCN0.35448157
109JAK30.35311943
110PDK20.33066581
111NEK90.32777837
112MAPK10.32767472
113CAMK40.32478656
114MKNK10.32171593
115MAPKAPK20.30731458
116MTOR0.30467032
117PRKCG0.29114175
118SRC0.29108400
119ZAP700.28454830
120DAPK30.28239373
121ACVR1B0.27816591
122MKNK20.27378554
123MAPKAPK30.26438461
124HIPK20.25921796
125PRKCD0.25757843
126CAMK2D0.25488612
127LIMK10.25270580
128MAPK30.25142691
129PRKG10.25100920
130PHKG10.24802563
131PHKG20.24802563
132KIT0.24052332
133MAPK40.23924777
134NEK10.23526687

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.88295212
2Protein digestion and absorption_Homo sapiens_hsa049744.71519744
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.54310295
4Focal adhesion_Homo sapiens_hsa045103.17834047
5TGF-beta signaling pathway_Homo sapiens_hsa043502.38548587
6Basal cell carcinoma_Homo sapiens_hsa052172.27687714
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.06968548
8* Proteoglycans in cancer_Homo sapiens_hsa052052.00479328
9Amoebiasis_Homo sapiens_hsa051461.98253734
10PI3K-Akt signaling pathway_Homo sapiens_hsa041511.94463422
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.82149350
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81766100
13Malaria_Homo sapiens_hsa051441.78725999
14Hippo signaling pathway_Homo sapiens_hsa043901.74650043
15Pertussis_Homo sapiens_hsa051331.72843388
16Hedgehog signaling pathway_Homo sapiens_hsa043401.70764181
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67676364
18Dilated cardiomyopathy_Homo sapiens_hsa054141.63905922
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58564002
20Adherens junction_Homo sapiens_hsa045201.58150378
21Starch and sucrose metabolism_Homo sapiens_hsa005001.37658987
22Complement and coagulation cascades_Homo sapiens_hsa046101.37376336
23Wnt signaling pathway_Homo sapiens_hsa043101.36398632
24Mineral absorption_Homo sapiens_hsa049781.29099718
25Thyroid hormone synthesis_Homo sapiens_hsa049181.27799094
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21555264
27Melanogenesis_Homo sapiens_hsa049161.15920640
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12759497
29Small cell lung cancer_Homo sapiens_hsa052221.10583822
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10576909
31Ovarian steroidogenesis_Homo sapiens_hsa049131.10214034
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09430716
33Renin-angiotensin system_Homo sapiens_hsa046141.07885846
34Prostate cancer_Homo sapiens_hsa052151.07745901
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05061101
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03761697
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00877951
38Arachidonic acid metabolism_Homo sapiens_hsa005901.00635991
39Glycosaminoglycan degradation_Homo sapiens_hsa005310.98758507
40Pathways in cancer_Homo sapiens_hsa052000.97958363
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97567325
42Lysine degradation_Homo sapiens_hsa003100.96305616
43MicroRNAs in cancer_Homo sapiens_hsa052060.92101173
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91906355
45Protein export_Homo sapiens_hsa030600.85819371
46Viral myocarditis_Homo sapiens_hsa054160.84371836
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81689619
48Melanoma_Homo sapiens_hsa052180.78174106
49TNF signaling pathway_Homo sapiens_hsa046680.73520008
50African trypanosomiasis_Homo sapiens_hsa051430.73474774
51N-Glycan biosynthesis_Homo sapiens_hsa005100.71929687
52Chemical carcinogenesis_Homo sapiens_hsa052040.71753023
53Staphylococcus aureus infection_Homo sapiens_hsa051500.71297713
54Chronic myeloid leukemia_Homo sapiens_hsa052200.71176189
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70500247
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69808418
57Colorectal cancer_Homo sapiens_hsa052100.68014094
58Bladder cancer_Homo sapiens_hsa052190.67948805
59Insulin resistance_Homo sapiens_hsa049310.66977501
60Other glycan degradation_Homo sapiens_hsa005110.66591016
61Glioma_Homo sapiens_hsa052140.66454288
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.64637650
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63602643
64Toxoplasmosis_Homo sapiens_hsa051450.62591105
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62435209
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62367978
67Vitamin digestion and absorption_Homo sapiens_hsa049770.62324821
68Circadian rhythm_Homo sapiens_hsa047100.62300805
69PPAR signaling pathway_Homo sapiens_hsa033200.61579223
70Platelet activation_Homo sapiens_hsa046110.60479089
71Estrogen signaling pathway_Homo sapiens_hsa049150.60372974
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59444950
73Glutathione metabolism_Homo sapiens_hsa004800.58677747
74Endometrial cancer_Homo sapiens_hsa052130.58208006
75Rap1 signaling pathway_Homo sapiens_hsa040150.57086167
76HTLV-I infection_Homo sapiens_hsa051660.56246233
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.56196211
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.54736121
79Axon guidance_Homo sapiens_hsa043600.54525442
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.53736498
81Hepatitis C_Homo sapiens_hsa051600.53146391
82Retinol metabolism_Homo sapiens_hsa008300.52848653
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52444260
84Sphingolipid metabolism_Homo sapiens_hsa006000.51288902
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50955943
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50929925
87Ras signaling pathway_Homo sapiens_hsa040140.50484697
88Pancreatic cancer_Homo sapiens_hsa052120.48029261
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47500789
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45892777
91Dorso-ventral axis formation_Homo sapiens_hsa043200.44379138
92Fat digestion and absorption_Homo sapiens_hsa049750.43588073
93Influenza A_Homo sapiens_hsa051640.43244830
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.42739688
95Hepatitis B_Homo sapiens_hsa051610.42166243
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41434343
97Arginine and proline metabolism_Homo sapiens_hsa003300.39720089
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39571619
99Prion diseases_Homo sapiens_hsa050200.39159468
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38346747
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37998937
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37991154
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37922028
104Osteoclast differentiation_Homo sapiens_hsa043800.37918812
105ABC transporters_Homo sapiens_hsa020100.37437412
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36908812
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36280154
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36208801
109Gap junction_Homo sapiens_hsa045400.35651637
110Choline metabolism in cancer_Homo sapiens_hsa052310.35247173
111Phenylalanine metabolism_Homo sapiens_hsa003600.34390235
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33632483
113Cocaine addiction_Homo sapiens_hsa050300.33522791
114Phagosome_Homo sapiens_hsa041450.33187685
115Nitrogen metabolism_Homo sapiens_hsa009100.33113150
116Endocytosis_Homo sapiens_hsa041440.32185903
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31968342
118FoxO signaling pathway_Homo sapiens_hsa040680.30347122
119Notch signaling pathway_Homo sapiens_hsa043300.30333845
120Lysosome_Homo sapiens_hsa041420.30003182
121Vibrio cholerae infection_Homo sapiens_hsa051100.29266091
122Renal cell carcinoma_Homo sapiens_hsa052110.29061394
123AMPK signaling pathway_Homo sapiens_hsa041520.28417013
124Galactose metabolism_Homo sapiens_hsa000520.28031326
125Tight junction_Homo sapiens_hsa045300.27962648
126Rheumatoid arthritis_Homo sapiens_hsa053230.27852103
127Renin secretion_Homo sapiens_hsa049240.24992864
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.24549911
129Sulfur metabolism_Homo sapiens_hsa009200.24265879
130Propanoate metabolism_Homo sapiens_hsa006400.23825805

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »