LURAP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.36186541
2L-phenylalanine catabolic process (GO:0006559)6.36186541
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.27435305
4L-phenylalanine metabolic process (GO:0006558)6.27435305
5desmosome organization (GO:0002934)5.54820483
6negative regulation of fibrinolysis (GO:0051918)5.34087661
7aromatic amino acid family catabolic process (GO:0009074)5.29296659
8regulation of fibrinolysis (GO:0051917)4.92050363
9peptidyl-glutamic acid carboxylation (GO:0017187)4.89523964
10protein carboxylation (GO:0018214)4.89523964
11sulfur amino acid catabolic process (GO:0000098)4.85361857
12Golgi transport vesicle coating (GO:0048200)4.84531963
13COPI coating of Golgi vesicle (GO:0048205)4.84531963
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.77025261
15bile acid biosynthetic process (GO:0006699)4.74661380
16hemidesmosome assembly (GO:0031581)4.62692038
17cysteine metabolic process (GO:0006534)4.62458814
18alpha-linolenic acid metabolic process (GO:0036109)4.51806926
19regulation of protein activation cascade (GO:2000257)4.40224354
20kynurenine metabolic process (GO:0070189)4.38944416
21tryptophan catabolic process (GO:0006569)4.38337867
22indole-containing compound catabolic process (GO:0042436)4.38337867
23indolalkylamine catabolic process (GO:0046218)4.38337867
24urea cycle (GO:0000050)4.38011393
25urea metabolic process (GO:0019627)4.38011393
26intestinal cholesterol absorption (GO:0030299)4.33135711
27high-density lipoprotein particle remodeling (GO:0034375)4.21978327
28glyoxylate metabolic process (GO:0046487)4.19866469
29regulation of complement activation (GO:0030449)4.15338870
30tryptophan metabolic process (GO:0006568)4.15311930
31homocysteine metabolic process (GO:0050667)4.12526756
32bile acid metabolic process (GO:0008206)4.09723665
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07913309
34complement activation, alternative pathway (GO:0006957)4.07398411
35nitrogen cycle metabolic process (GO:0071941)4.00953680
36cellular ketone body metabolic process (GO:0046950)3.90779056
37regulation of water loss via skin (GO:0033561)3.90566443
38aromatic amino acid family metabolic process (GO:0009072)3.88690760
39reverse cholesterol transport (GO:0043691)3.88206510
40regulation of triglyceride catabolic process (GO:0010896)3.85083125
41lysine catabolic process (GO:0006554)3.84929158
42lysine metabolic process (GO:0006553)3.84929158
43cellular glucuronidation (GO:0052695)3.82112237
44fibrinolysis (GO:0042730)3.80696966
45acylglycerol homeostasis (GO:0055090)3.78285868
46triglyceride homeostasis (GO:0070328)3.78285868
47epoxygenase P450 pathway (GO:0019373)3.78253153
48regulation of cholesterol homeostasis (GO:2000188)3.74328807
49cell adhesion mediated by integrin (GO:0033627)3.73986679
50regulation of bile acid biosynthetic process (GO:0070857)3.73247872
51bile acid and bile salt transport (GO:0015721)3.69691874
52coenzyme catabolic process (GO:0009109)3.69666325
53drug catabolic process (GO:0042737)3.68274409
54tyrosine metabolic process (GO:0006570)3.67889146
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.65849604
56amino-acid betaine metabolic process (GO:0006577)3.57505704
57regulation of cholesterol esterification (GO:0010872)3.55865084
58negative regulation of sterol transport (GO:0032372)3.55845280
59negative regulation of cholesterol transport (GO:0032375)3.55845280
60COPII vesicle coating (GO:0048208)3.52657839
61uronic acid metabolic process (GO:0006063)3.52152213
62glucuronate metabolic process (GO:0019585)3.52152213
63cellular modified amino acid catabolic process (GO:0042219)3.50369781
64serine family amino acid catabolic process (GO:0009071)3.50092200
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49408613
66type B pancreatic cell proliferation (GO:0044342)3.47903042
67plasma lipoprotein particle remodeling (GO:0034369)3.47815810
68protein-lipid complex remodeling (GO:0034368)3.47815810
69macromolecular complex remodeling (GO:0034367)3.47815810
70skin morphogenesis (GO:0043589)3.47537721
71establishment of skin barrier (GO:0061436)3.45891518
72regulation of plasminogen activation (GO:0010755)3.45867401
73alpha-amino acid catabolic process (GO:1901606)3.45511352
74flavonoid metabolic process (GO:0009812)3.43464706
75aldehyde catabolic process (GO:0046185)3.40642436
76phospholipid efflux (GO:0033700)3.39953108
77prostate gland growth (GO:0060736)3.37564996
78glutamate metabolic process (GO:0006536)3.35541484
79ketone body metabolic process (GO:1902224)3.33009243
80plasma lipoprotein particle clearance (GO:0034381)3.32955241
81cellular amino acid catabolic process (GO:0009063)3.28808442
82mammary gland epithelial cell differentiation (GO:0060644)3.28593443
83intestinal absorption (GO:0050892)3.24711676
84cholesterol efflux (GO:0033344)3.23508461
85activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.21678601
86positive regulation of fatty acid biosynthetic process (GO:0045723)3.21595197
87negative regulation of protein activation cascade (GO:2000258)3.21455487
88iron ion import (GO:0097286)3.19220361
89negative regulation of lipase activity (GO:0060192)3.19004045
90drug metabolic process (GO:0017144)3.17732892
91bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16739513
92ovulation from ovarian follicle (GO:0001542)3.15110000
93opsonization (GO:0008228)3.13834400
94regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.13507003
95arginine metabolic process (GO:0006525)3.10758049
96ethanol oxidation (GO:0006069)3.10001113
97indolalkylamine metabolic process (GO:0006586)3.08840768
98benzene-containing compound metabolic process (GO:0042537)3.07834027
99dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.07702004
100exogenous drug catabolic process (GO:0042738)3.06720394
101cholesterol homeostasis (GO:0042632)3.06193853
102lipoprotein metabolic process (GO:0042157)3.05870535
103cofactor catabolic process (GO:0051187)3.05263994
104regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.04502894
105sterol homeostasis (GO:0055092)3.03720993
106branching involved in mammary gland duct morphogenesis (GO:0060444)3.03002781
107sequestering of extracellular ligand from receptor (GO:0035581)3.01185830
108positive regulation of lipid catabolic process (GO:0050996)2.98104067
109positive regulation of lipoprotein lipase activity (GO:0051006)2.95459928
110positive regulation of triglyceride lipase activity (GO:0061365)2.95459928
111macroautophagy (GO:0016236)2.95311718
112epithelial cell-cell adhesion (GO:0090136)2.93153911
113response to nitrosative stress (GO:0051409)2.92801295
114complement activation, classical pathway (GO:0006958)2.92797773
115serine family amino acid metabolic process (GO:0009069)2.91555849
116cytolysis (GO:0019835)2.91080592
117acute-phase response (GO:0006953)2.91014076
118retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.90650367
119organic acid catabolic process (GO:0016054)2.88973490
120carboxylic acid catabolic process (GO:0046395)2.88973490
121plasma lipoprotein particle assembly (GO:0034377)2.88630994
122imidazole-containing compound metabolic process (GO:0052803)2.87432891
123drug transmembrane transport (GO:0006855)2.86869320
124protein retention in ER lumen (GO:0006621)2.84021541
125multicellular organismal water homeostasis (GO:0050891)2.84016297
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84003392
127positive regulation of fatty acid beta-oxidation (GO:0032000)2.83963714
128cell-substrate junction assembly (GO:0007044)2.83295571
129negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.82720167
130tonic smooth muscle contraction (GO:0014820)2.70185586
131endocardial cushion development (GO:0003197)2.67534013
132mammary gland alveolus development (GO:0060749)2.67285642
133lung lobe morphogenesis (GO:0060463)2.67123677
134negative regulation of complement activation (GO:0045916)2.66046420
135vesicle coating (GO:0006901)2.65548780
136surfactant homeostasis (GO:0043129)2.63760589
137negative regulation of keratinocyte proliferation (GO:0010839)2.62068226
138heparin biosynthetic process (GO:0030210)2.57716231
139heparin metabolic process (GO:0030202)2.57716231
140tight junction assembly (GO:0070830)2.54255103
141ER overload response (GO:0006983)2.52076588
142water homeostasis (GO:0030104)2.50367991
143keratan sulfate catabolic process (GO:0042340)2.49455738
144negative regulation of protein localization to plasma membrane (GO:1903077)2.48230064
145basement membrane organization (GO:0071711)2.48138097
146biotin metabolic process (GO:0006768)2.47072240
147regulation of integrin-mediated signaling pathway (GO:2001044)2.47070490
148intestinal epithelial cell development (GO:0060576)2.46401875
149endocrine hormone secretion (GO:0060986)2.45788089
150L-serine transport (GO:0015825)2.42580585
151insulin-like growth factor receptor signaling pathway (GO:0048009)2.40643907
152artery smooth muscle contraction (GO:0014824)2.40547833
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.40401103
154smooth muscle tissue development (GO:0048745)2.39233612
155collagen fibril organization (GO:0030199)2.34270184
156cardiac right ventricle morphogenesis (GO:0003215)2.33736824
157polarized epithelial cell differentiation (GO:0030859)2.32596200
158regulation of hippo signaling (GO:0035330)2.31765771
159regulation of type B pancreatic cell apoptotic process (GO:2000674)2.29738775
160activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.29417575
161embryo implantation (GO:0007566)2.27963890
162cytoskeletal anchoring at plasma membrane (GO:0007016)2.27928080
163polyketide metabolic process (GO:0030638)2.26148204
164doxorubicin metabolic process (GO:0044598)2.26148204
165daunorubicin metabolic process (GO:0044597)2.26148204
166positive regulation of endothelial cell apoptotic process (GO:2000353)2.24346961
167negative regulation of fatty acid transport (GO:2000192)2.23897343
168regulation of protein localization to cell surface (GO:2000008)2.23493705
169endoplasmic reticulum unfolded protein response (GO:0030968)2.23266767
170protein localization to endosome (GO:0036010)2.22989716
171retinal metabolic process (GO:0042574)2.22526041
172regulation of extracellular matrix disassembly (GO:0010715)2.22519199
173epithelial cell maturation (GO:0002070)2.21299617
174peptidyl-proline hydroxylation (GO:0019511)2.20643422
175positive regulation of actin filament depolymerization (GO:0030836)2.20340384
176protein hydroxylation (GO:0018126)2.19740955
177amyloid precursor protein metabolic process (GO:0042982)2.19499391
178endodermal cell differentiation (GO:0035987)2.19338949
179amyloid precursor protein catabolic process (GO:0042987)2.18219053
180negative regulation of chondrocyte differentiation (GO:0032331)2.16952071
181gap junction assembly (GO:0016264)2.16102273
182protein heterotrimerization (GO:0070208)2.16100466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.26415609
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.98037739
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.10338378
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.71464107
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.21487430
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.62687439
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.54795181
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.44697960
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.32751376
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.15775967
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.06826253
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96129980
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.60840872
14CLOCK_20551151_ChIP-Seq_293T_Human2.57326616
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.12327158
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94010319
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85275180
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.83461892
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79076271
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72346429
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.69074825
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66571316
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63050696
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63050696
25SOX2_20726797_ChIP-Seq_SW620_Human1.62742985
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.53260264
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53133170
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.47471824
29GATA4_25053715_ChIP-Seq_YYC3_Human1.40214377
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40044066
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.32865690
32ZNF263_19887448_ChIP-Seq_K562_Human1.32098449
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.32096964
34CJUN_26792858_Chip-Seq_BT549_Human1.30551717
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28526405
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27313368
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25340195
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22923306
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.21073834
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.19932243
41BRD4_25478319_ChIP-Seq_HGPS_Human1.19057441
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17871047
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17150658
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15711462
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.12540728
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11592407
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09227670
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09088718
49EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08914993
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07861716
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06474541
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05108571
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.04724950
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03300508
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03149907
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01937509
57ELF5_23300383_ChIP-Seq_T47D_Human1.01371176
58PIAS1_25552417_ChIP-Seq_VCAP_Human0.97928231
59TP53_18474530_ChIP-ChIP_U2OS_Human0.97385431
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97369053
61P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96619479
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95210631
63GATA6_25053715_ChIP-Seq_YYC3_Human0.94294918
64ATF3_27146783_Chip-Seq_COLON_Human0.93779206
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93607624
66PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93476216
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92330985
68KLF5_25053715_ChIP-Seq_YYC3_Human0.90005786
69HTT_18923047_ChIP-ChIP_STHdh_Human0.89600279
70BCAT_22108803_ChIP-Seq_LS180_Human0.89478043
71TP53_16413492_ChIP-PET_HCT116_Human0.89411552
72UBF1/2_26484160_Chip-Seq_HMECs_Human0.89088296
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87853702
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87305489
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86781195
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86268321
77TBX20_22328084_ChIP-Seq_HEART_Mouse0.85012164
78TBX20_22080862_ChIP-Seq_HEART_Mouse0.85012164
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84478937
80CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84327092
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83376696
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83376696
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83282733
84GATA3_24758297_ChIP-Seq_MCF-7_Human0.82719905
85RACK7_27058665_Chip-Seq_MCF-7_Human0.82116212
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81772797
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81031956
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79640195
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.79624110
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78866038
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77762838
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76430693
93P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76148319
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75053768
95SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74593505
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74557558
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74526134
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74168068
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.72948105
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72735958
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72160864
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71891068
103MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.71859274
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70963346
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70314236
106TP63_23658742_ChIP-Seq_EP156T_Human0.70094597
107FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69806686
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.67603658
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.66226951
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.66206432
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.65676856
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.65092151
113MTF2_20144788_ChIP-Seq_MESCs_Mouse0.64738787
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.64658187
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63698119
116EED_16625203_ChIP-ChIP_MESCs_Mouse0.62981843
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.61483197
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61168305
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.61070202
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.58657617
121AHR_22903824_ChIP-Seq_MCF-7_Human0.58651350
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.58196292
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.57456830
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.57444321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.87519475
2MP0005360_urolithiasis5.86369527
3MP0005085_abnormal_gallbladder_physiolo5.03321649
4MP0005365_abnormal_bile_salt4.69859751
5MP0008875_abnormal_xenobiotic_pharmacok4.03186165
6MP0003252_abnormal_bile_duct3.85508158
7MP0003705_abnormal_hypodermis_morpholog3.24337446
8MP0005083_abnormal_biliary_tract3.21361257
9MP0003806_abnormal_nucleotide_metabolis3.04841281
10MP0001666_abnormal_nutrient_absorption2.99424446
11MP0002138_abnormal_hepatobiliary_system2.86041124
12MP0008438_abnormal_cutaneous_collagen2.74182757
13MP0003195_calcinosis2.68727881
14MP0010329_abnormal_lipoprotein_level2.57406967
15MP0005248_abnormal_Harderian_gland2.40838548
16MP0009840_abnormal_foam_cell2.36453407
17MP0010234_abnormal_vibrissa_follicle2.32770751
18MP0001346_abnormal_lacrimal_gland2.20102131
19MP0005084_abnormal_gallbladder_morpholo2.16453457
20MP0003941_abnormal_skin_development2.14787846
21MP0005332_abnormal_amino_acid2.12960507
22MP0005275_abnormal_skin_tensile2.06389874
23MP0009384_cardiac_valve_regurgitation2.02359381
24MP0002098_abnormal_vibrissa_morphology1.89172929
25MP0003868_abnormal_feces_composition1.81555521
26MP0005501_abnormal_skin_physiology1.80977672
27MP0010678_abnormal_skin_adnexa1.77325822
28MP0005220_abnormal_exocrine_pancreas1.74178084
29MP0004019_abnormal_vitamin_homeostasis1.69027350
30MP0000627_abnormal_mammary_gland1.61019117
31MP0001881_abnormal_mammary_gland1.56515811
32MP0000762_abnormal_tongue_morphology1.55868249
33MP0010368_abnormal_lymphatic_system1.52567819
34MP0002118_abnormal_lipid_homeostasis1.52419335
35MP0003191_abnormal_cellular_cholesterol1.48131212
36MP0000467_abnormal_esophagus_morphology1.46542997
37MP0000609_abnormal_liver_physiology1.45958793
38MP0002928_abnormal_bile_duct1.42550637
39MP0003950_abnormal_plasma_membrane1.42435286
40MP0004233_abnormal_muscle_weight1.33461651
41MP0005379_endocrine/exocrine_gland_phen1.32418365
42MP0002295_abnormal_pulmonary_circulatio1.29885464
43MP0000383_abnormal_hair_follicle1.29112705
44MP0002060_abnormal_skin_morphology1.27051447
45MP0003279_aneurysm1.26444190
46MP0005623_abnormal_meninges_morphology1.25607262
47MP0001216_abnormal_epidermal_layer1.24814154
48MP0005319_abnormal_enzyme/_coenzyme1.22894948
49MP0000377_abnormal_hair_follicle1.21268558
50MP0002877_abnormal_melanocyte_morpholog1.18323245
51MP0003300_gastrointestinal_ulcer1.16325588
52MP0009643_abnormal_urine_homeostasis1.15599935
53MP0001661_extended_life_span1.12969470
54MP0001919_abnormal_reproductive_system1.11559265
55MP0000013_abnormal_adipose_tissue1.10222172
56MP0005058_abnormal_lysosome_morphology1.10104676
57MP0000767_abnormal_smooth_muscle1.08109134
58MP0003329_amyloid_beta_deposits1.07962890
59MP0005508_abnormal_skeleton_morphology1.06905485
60MP0001849_ear_inflammation1.05578802
61MP0003283_abnormal_digestive_organ1.04963117
62MP0004272_abnormal_basement_membrane1.04140387
63MP0002108_abnormal_muscle_morphology1.03110641
64MP0000003_abnormal_adipose_tissue1.02193796
65MP0002909_abnormal_adrenal_gland1.02083025
66MP0009780_abnormal_chondrocyte_physiolo0.99403246
67MP0005503_abnormal_tendon_morphology0.98547218
68MP0005409_darkened_coat_color0.98103818
69MP0002168_other_aberrant_phenotype0.98055834
70MP0005023_abnormal_wound_healing0.97700472
71MP0006054_spinal_hemorrhage0.97698238
72MP0000462_abnormal_digestive_system0.97682585
73MP0008004_abnormal_stomach_pH0.96727319
74MP0005408_hypopigmentation0.95657398
75MP0001958_emphysema0.95612948
76MP0004264_abnormal_extraembryonic_tissu0.95210147
77MP0003011_delayed_dark_adaptation0.93831517
78MP0002796_impaired_skin_barrier0.89934282
79MP0009053_abnormal_anal_canal0.87859000
80MP0000604_amyloidosis0.87584876
81MP0009697_abnormal_copulation0.84382585
82MP0003936_abnormal_reproductive_system0.84099965
83MP0009379_abnormal_foot_pigmentation0.83365581
84MP0005395_other_phenotype0.82946119
85MP0000598_abnormal_liver_morphology0.81136608
86MP0001944_abnormal_pancreas_morphology0.80878058
87MP0002089_abnormal_postnatal_growth/wei0.80805602
88MP0003566_abnormal_cell_adhesion0.79950153
89MP0001764_abnormal_homeostasis0.79643391
90MP0005584_abnormal_enzyme/coenzyme_acti0.79477396
91MP0005636_abnormal_mineral_homeostasis0.79342884
92MP0001879_abnormal_lymphatic_vessel0.78708530
93MP0002896_abnormal_bone_mineralization0.78356610
94MP0010352_gastrointestinal_tract_polyps0.77688074
95MP0000534_abnormal_ureter_morphology0.76405916
96MP0002254_reproductive_system_inflammat0.75671953
97MP0000538_abnormal_urinary_bladder0.74730200
98MP0000163_abnormal_cartilage_morphology0.74328698
99MP0001243_abnormal_dermal_layer0.74147435
100MP0001542_abnormal_bone_strength0.72854045
101MP0000566_synostosis0.72227700
102MP0000613_abnormal_salivary_gland0.71821436
103MP0003942_abnormal_urinary_system0.71033618
104MP0009931_abnormal_skin_appearance0.69914238
105MP0005595_abnormal_vascular_smooth0.68582359
106MP0010386_abnormal_urinary_bladder0.68003110
107MP0001756_abnormal_urination0.67914440
108MP0005257_abnormal_intraocular_pressure0.67758644
109MP0002837_dystrophic_cardiac_calcinosis0.67667649
110MP0002078_abnormal_glucose_homeostasis0.67279183
111MP0003186_abnormal_redox_activity0.65899155
112MP0000537_abnormal_urethra_morphology0.64834977
113MP0002876_abnormal_thyroid_physiology0.64363264
114MP0005164_abnormal_response_to0.61041348
115MP0004782_abnormal_surfactant_physiolog0.60534562
116MP0005165_increased_susceptibility_to0.58696258
117MP0003045_fibrosis0.58220546
118MP0003091_abnormal_cell_migration0.57982896
119MP0005647_abnormal_sex_gland0.57501679
120MP0001664_abnormal_digestion0.57031853
121MP0009764_decreased_sensitivity_to0.56305915
122MP0003453_abnormal_keratinocyte_physiol0.56111621
123MP0009642_abnormal_blood_homeostasis0.56062996
124MP0004883_abnormal_blood_vessel0.55847820
125MP0005376_homeostasis/metabolism_phenot0.54154440
126MP0005451_abnormal_body_composition0.54049943
127MP0010030_abnormal_orbit_morphology0.52078019
128MP0001765_abnormal_ion_homeostasis0.51120910
129MP0009763_increased_sensitivity_to0.50653255
130MP0005187_abnormal_penis_morphology0.49781265
131MP0000579_abnormal_nail_morphology0.49114147
132MP0002282_abnormal_trachea_morphology0.47485898
133MP0000427_abnormal_hair_cycle0.46781314
134MP0003638_abnormal_response/metabolism_0.45925859
135MP0003959_abnormal_lean_body0.45256785
136MP0005448_abnormal_energy_balance0.45163659
137MP0010771_integument_phenotype0.43198359

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.26829662
2Deep venous thrombosis (HP:0002625)6.21215436
3Intrahepatic cholestasis (HP:0001406)5.72746926
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.39467939
5Xanthomatosis (HP:0000991)5.22250022
6Hypobetalipoproteinemia (HP:0003563)4.95815272
7Prolonged partial thromboplastin time (HP:0003645)4.61867804
8Protrusio acetabuli (HP:0003179)4.12845113
9Hypolipoproteinemia (HP:0010981)3.93152202
10Complement deficiency (HP:0004431)3.89043071
11Hyperlipoproteinemia (HP:0010980)3.86942765
12Abnormality of the common coagulation pathway (HP:0010990)3.86156170
13Fat malabsorption (HP:0002630)3.77982823
14Premature rupture of membranes (HP:0001788)3.63826901
15Gout (HP:0001997)3.61158126
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.59195086
17Hypoalphalipoproteinemia (HP:0003233)3.58972023
18Abnormality of the intrinsic pathway (HP:0010989)3.54738938
19Sparse lateral eyebrow (HP:0005338)3.54260388
20Menorrhagia (HP:0000132)3.53409786
21Right ventricular cardiomyopathy (HP:0011663)3.44923240
22Abnormality of nail color (HP:0100643)3.42446964
23Conjugated hyperbilirubinemia (HP:0002908)3.40166037
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39847606
25Cervical subluxation (HP:0003308)3.36341676
26Ketosis (HP:0001946)3.28245357
27Hypoglycemic coma (HP:0001325)3.28104906
28Hyperammonemia (HP:0001987)3.26014617
29Vascular tortuosity (HP:0004948)3.22926924
30Arterial tortuosity (HP:0005116)3.14850201
31Broad metatarsal (HP:0001783)3.12667712
32Epidermoid cyst (HP:0200040)3.12562411
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.12175487
34Follicular hyperkeratosis (HP:0007502)3.12127023
35Abnormality of complement system (HP:0005339)3.07112848
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.06833253
37Peritonitis (HP:0002586)2.95751821
38Abnormality of methionine metabolism (HP:0010901)2.87262382
39Steatorrhea (HP:0002570)2.85622560
40Concave nail (HP:0001598)2.84687852
41Hyperglycinemia (HP:0002154)2.79342236
42Skin nodule (HP:0200036)2.76267241
43Abnormality of purine metabolism (HP:0004352)2.73477262
44Malnutrition (HP:0004395)2.72666185
45Flat capital femoral epiphysis (HP:0003370)2.71348909
46Oligomenorrhea (HP:0000876)2.69186631
47Pili torti (HP:0003777)2.68978137
48Ileus (HP:0002595)2.68441757
49Ketoacidosis (HP:0001993)2.67626834
50Mucopolysacchariduria (HP:0008155)2.65936231
51Urinary glycosaminoglycan excretion (HP:0003541)2.65936231
52Abnormality of the proximal phalanges of the hand (HP:0009834)2.65868879
53Abnormality of the distal phalanges of the toes (HP:0010182)2.65645422
54Joint hemorrhage (HP:0005261)2.63238620
55Esophageal varix (HP:0002040)2.62473141
56Vertebral compression fractures (HP:0002953)2.61141667
57Cardiovascular calcification (HP:0011915)2.53219484
58Spontaneous abortion (HP:0005268)2.49746770
59Hypercholesterolemia (HP:0003124)2.49607113
60Abnormality of nucleobase metabolism (HP:0010932)2.47376494
61Abnormality of glycine metabolism (HP:0010895)2.46959849
62Abnormality of serine family amino acid metabolism (HP:0010894)2.46959849
63Late onset (HP:0003584)2.44944308
64Hepatocellular carcinoma (HP:0001402)2.44555729
65Hyperglycinuria (HP:0003108)2.42583329
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41769528
67Abnormality of polysaccharide metabolism (HP:0011012)2.41769528
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41769528
69Atrophic scars (HP:0001075)2.41607531
70Myocardial infarction (HP:0001658)2.41187789
71Infantile muscular hypotonia (HP:0008947)2.38060140
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.36296838
73Osteolytic defects of the hand bones (HP:0009699)2.36296838
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35013818
75Ankle contracture (HP:0006466)2.34957851
76Alopecia of scalp (HP:0002293)2.32827907
77Abnormality of fatty-acid metabolism (HP:0004359)2.32010497
78Blue sclerae (HP:0000592)2.32007159
79Flat acetabular roof (HP:0003180)2.31895452
80Mitral stenosis (HP:0001718)2.29570598
81Aortic aneurysm (HP:0004942)2.28431169
82Acanthosis nigricans (HP:0000956)2.27852634
83Vascular calcification (HP:0004934)2.26562184
84Osteoarthritis (HP:0002758)2.25676637
85Hyperglycemia (HP:0003074)2.24784771
86Hypoplasia of dental enamel (HP:0006297)2.24361721
87Congenital glaucoma (HP:0001087)2.24341359
88Natal tooth (HP:0000695)2.24158159
89Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.23710443
90Termporal pattern (HP:0011008)2.23666982
91Insidious onset (HP:0003587)2.23666982
92Aortic dissection (HP:0002647)2.20000710
93Abnormality of dentin (HP:0010299)2.18831186
94Advanced eruption of teeth (HP:0006288)2.18724251
95Hypoglycemic seizures (HP:0002173)2.18384843
96Increased purine levels (HP:0004368)2.18136670
97Hyperuricemia (HP:0002149)2.18136670
98Curly hair (HP:0002212)2.17511347
99Spastic diplegia (HP:0001264)2.16305978
100Abnormal gallbladder physiology (HP:0012438)2.15727477
101Cholecystitis (HP:0001082)2.15727477
102Hyperbilirubinemia (HP:0002904)2.15301744
103Abnormal cartilage morphology (HP:0002763)2.14760558
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.13753497
105Ovoid vertebral bodies (HP:0003300)2.11959516
106Sensorimotor neuropathy (HP:0007141)2.09974120
107Abnormality of carpal bone ossification (HP:0006257)2.09098706
108Abnormal hair laboratory examination (HP:0003328)2.09090982
109Thin bony cortex (HP:0002753)2.07255639
110Fragile skin (HP:0001030)2.07163587
111Dysostosis multiplex (HP:0000943)2.07149577
112Soft skin (HP:0000977)2.06941833
113Abnormality of serum amino acid levels (HP:0003112)2.04238383
114Milia (HP:0001056)2.04057484
115Abnormal delivery (HP:0001787)2.01175150
116Lethargy (HP:0001254)2.00295095
117Exostoses (HP:0100777)2.00080828
118Abnormality of the Achilles tendon (HP:0005109)1.96824254
119Potter facies (HP:0002009)1.96519699
120Facial shape deformation (HP:0011334)1.96519699
121Biconcave vertebral bodies (HP:0004586)1.96146373
122Wormian bones (HP:0002645)1.96018151
123Spinal rigidity (HP:0003306)1.95583218
124Coxa vara (HP:0002812)1.95446726
125Abnormality of pyrimidine metabolism (HP:0004353)1.95174958
126Bladder diverticulum (HP:0000015)1.95139357
127Ectopia lentis (HP:0001083)1.94658249
128Metabolic acidosis (HP:0001942)1.93863512
129Distal lower limb muscle weakness (HP:0009053)1.93040660
130Abdominal distention (HP:0003270)1.92674595
131Septate vagina (HP:0001153)1.92267241
132Enlarged kidneys (HP:0000105)1.92135528
133Abnormal gallbladder morphology (HP:0012437)1.91801843
134Fragile nails (HP:0001808)1.90095416
135Hydroxyprolinuria (HP:0003080)1.89443497
136Abnormality of proline metabolism (HP:0010907)1.89443497
137Abnormality of the acetabulum (HP:0003170)1.88497965
138Short nail (HP:0001799)1.87817049
139Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86480082
140Hyperinsulinemic hypoglycemia (HP:0000825)1.86081974
141Cholelithiasis (HP:0001081)1.82846013
142Back pain (HP:0003418)1.82436150
143Abnormal hand bone ossification (HP:0010660)1.81233320
144Glycosuria (HP:0003076)1.80901730
145Abnormality of urine glucose concentration (HP:0011016)1.80901730
146Cerebral aneurysm (HP:0004944)1.79713116
147Delayed CNS myelination (HP:0002188)1.79401887
148Irritability (HP:0000737)1.79359799
149Abnormality of the epiphyses of the hand (HP:0005924)1.78950763
150Joint stiffness (HP:0001387)1.78841354
151Buphthalmos (HP:0000557)1.78400289
152Abnormal hemoglobin (HP:0011902)1.78162249
153Neonatal onset (HP:0003623)1.77739766
154Neonatal short-limb short stature (HP:0008921)1.76861484
155Glomerulosclerosis (HP:0000096)1.76803852
156Turricephaly (HP:0000262)1.76742118
157Pancreatitis (HP:0001733)1.76696627
158Insulin resistance (HP:0000855)1.76368336
159Abnormal tarsal ossification (HP:0008369)1.76357465
160Cerebral edema (HP:0002181)1.76340701
161Amyloidosis (HP:0011034)1.75876232
162Opisthotonus (HP:0002179)1.75425245
163Sparse eyelashes (HP:0000653)1.73737709
164Abnormal ossification of hand bones (HP:0005921)1.73700829
165Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.70738094
166Pterygium (HP:0001059)1.70012575
167Aneurysm (HP:0002617)1.69946986
168Plantar hyperkeratosis (HP:0007556)1.67077030
169Mildly elevated creatine phosphokinase (HP:0008180)1.65240346
170Joint laxity (HP:0001388)1.65219102
171Neonatal death (HP:0003811)1.64869898
172Long toe (HP:0010511)1.63870633
173Microglossia (HP:0000171)1.63425788
174Hypotrichosis (HP:0001006)1.61832285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.06368779
2ERN13.57866107
3EPHA23.51916589
4BCKDK3.24182463
5MST1R2.90921743
6FGFR42.55777616
7FER2.42208441
8LATS12.38574060
9SIK12.34163150
10LATS22.20842718
11TRIB32.12383454
12ERBB42.10685329
13DDR22.02201718
14EPHB21.93191829
15PTK21.88741645
16PIK3CG1.74896203
17SCYL21.72603145
18MET1.71328354
19EIF2AK11.70265988
20PAK31.66270384
21TESK11.65527084
22MAP2K11.60057532
23PTK61.55803064
24TAOK31.54670738
25STK38L1.54217658
26MAPKAPK31.47838438
27MAP3K21.47019688
28PDGFRA1.44039332
29EPHA31.43230407
30STK381.41772712
31MYLK1.37374044
32PKN21.36889872
33INSRR1.33331359
34PIM21.23888511
35PIK3CA1.22728892
36DMPK1.22643936
37ICK1.21604180
38MOS1.21069273
39LMTK21.20028193
40MAP2K41.19486631
41MAPK151.18603667
42MAP2K21.18015497
43MAP3K31.15238757
44PTK2B1.15136316
45LIMK11.12005438
46ARAF1.11564435
47KSR21.08640471
48MAP3K91.05602316
49TTN1.03832064
50RIPK11.03058269
51ILK1.02737304
52PDGFRB1.01874557
53FGFR21.01530081
54EPHA40.99431965
55NME10.96419577
56NEK90.95979411
57ABL20.94663836
58NTRK10.94151109
59ERBB20.86045924
60PAK20.84121231
61MAP3K120.81783712
62MAP3K10.75957289
63KDR0.74903472
64PRKD20.74575692
65CAMK2G0.73460131
66DYRK1B0.73106381
67TESK20.72310584
68PRKG20.70820502
69MAP3K110.69449046
70TRPM70.67500038
71EPHB10.66218348
72PAK40.65791425
73RET0.65625333
74JAK10.62090229
75RPS6KB20.60292484
76FGFR30.59522208
77CAMK2B0.59222549
78NEK60.59113467
79MAPK110.58510136
80GRK50.57028027
81DAPK20.56819163
82MUSK0.56490104
83PRKCI0.56487882
84NME20.56063540
85ROCK20.54793139
86RPS6KA20.54743032
87ROCK10.54384241
88EIF2AK30.54227626
89FGFR10.53860091
90TGFBR20.53304926
91CAMK2D0.49312588
92CDC42BPA0.48310044
93LRRK20.48225129
94RPS6KA40.46567928
95BMX0.46560940
96BRAF0.46504488
97CDK60.46488888
98PRKCZ0.44854662
99MAP3K70.44301166
100ZAP700.43766682
101DAPK30.43640339
102WNK40.42298969
103CAMK2A0.41733079
104PNCK0.41567554
105GRK10.41407497
106PRKCE0.40493525
107FLT30.39981325
108CHUK0.39043473
109MAP3K130.38949092
110HIPK20.38000647
111AKT30.37655146
112SIK30.35608082
113MAPKAPK20.35109277
114SGK30.33622881
115IGF1R0.33432541
116TAOK20.33133069
117GSK3A0.33081812
118PRKD10.32726575
119PRKAA20.31894701
120JAK20.31315833
121KSR10.31165054
122ADRBK10.30561180
123SRC0.30217017
124STK30.29313486
125MST40.29233546
126TAOK10.28571539
127STK390.27378921
128INSR0.26725916
129PDK20.26441300
130NTRK30.26247069
131GRK60.26179352
132MTOR0.26019880
133STK240.25180035
134CDK80.25073615
135TSSK60.24889547

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.17922967
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30908546
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26169114
4Nitrogen metabolism_Homo sapiens_hsa009102.92058464
5Arginine biosynthesis_Homo sapiens_hsa002202.67994960
6Tryptophan metabolism_Homo sapiens_hsa003802.51286550
7Sulfur metabolism_Homo sapiens_hsa009202.49649098
8Complement and coagulation cascades_Homo sapiens_hsa046102.46315334
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.32745517
10Fatty acid degradation_Homo sapiens_hsa000712.20957947
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17836580
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17562776
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.14293417
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13476456
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10461579
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08526762
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04007474
18Chemical carcinogenesis_Homo sapiens_hsa052042.03053662
19Butanoate metabolism_Homo sapiens_hsa006501.96451327
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96281815
21Caffeine metabolism_Homo sapiens_hsa002321.93021788
22Histidine metabolism_Homo sapiens_hsa003401.79416363
23Peroxisome_Homo sapiens_hsa041461.79096628
24Fat digestion and absorption_Homo sapiens_hsa049751.73562909
25Bile secretion_Homo sapiens_hsa049761.63262394
26PPAR signaling pathway_Homo sapiens_hsa033201.62366643
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.60815532
28Retinol metabolism_Homo sapiens_hsa008301.50961907
29Phenylalanine metabolism_Homo sapiens_hsa003601.49472097
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48110835
31Propanoate metabolism_Homo sapiens_hsa006401.46796279
32Sphingolipid metabolism_Homo sapiens_hsa006001.45468944
33Selenocompound metabolism_Homo sapiens_hsa004501.45467868
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44801297
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.42350886
36Fatty acid metabolism_Homo sapiens_hsa012121.41666147
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39058161
38Pyruvate metabolism_Homo sapiens_hsa006201.33183732
39Starch and sucrose metabolism_Homo sapiens_hsa005001.32868228
40beta-Alanine metabolism_Homo sapiens_hsa004101.31754191
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28579843
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24837967
43Tyrosine metabolism_Homo sapiens_hsa003501.23110450
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22124625
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21973441
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.18659267
47Folate biosynthesis_Homo sapiens_hsa007901.18225383
48N-Glycan biosynthesis_Homo sapiens_hsa005101.14155526
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11744797
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09243244
51Proteoglycans in cancer_Homo sapiens_hsa052051.04190241
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03062502
53Other glycan degradation_Homo sapiens_hsa005111.02784754
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97789289
55Thyroid cancer_Homo sapiens_hsa052160.97456782
56Sulfur relay system_Homo sapiens_hsa041220.96468517
57Arginine and proline metabolism_Homo sapiens_hsa003300.96385891
58Biosynthesis of amino acids_Homo sapiens_hsa012300.95485022
59Carbon metabolism_Homo sapiens_hsa012000.92984055
60Vitamin digestion and absorption_Homo sapiens_hsa049770.91062439
61Fatty acid elongation_Homo sapiens_hsa000620.89224380
62Steroid biosynthesis_Homo sapiens_hsa001000.87207822
63Staphylococcus aureus infection_Homo sapiens_hsa051500.85084845
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84952360
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.83413178
66Glutathione metabolism_Homo sapiens_hsa004800.82338524
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80567986
68ABC transporters_Homo sapiens_hsa020100.79159136
69Lysosome_Homo sapiens_hsa041420.77566666
70Dilated cardiomyopathy_Homo sapiens_hsa054140.76384615
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74025061
72Small cell lung cancer_Homo sapiens_hsa052220.73575331
73Circadian rhythm_Homo sapiens_hsa047100.71742021
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70993103
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70941141
76Glycerolipid metabolism_Homo sapiens_hsa005610.70672010
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66149641
78TGF-beta signaling pathway_Homo sapiens_hsa043500.66009196
79Arachidonic acid metabolism_Homo sapiens_hsa005900.65562859
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.65489420
81Renal cell carcinoma_Homo sapiens_hsa052110.64676950
82Axon guidance_Homo sapiens_hsa043600.64619683
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64609660
84Endocytosis_Homo sapiens_hsa041440.64374004
85Protein digestion and absorption_Homo sapiens_hsa049740.64125777
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63465272
87Prolactin signaling pathway_Homo sapiens_hsa049170.63048005
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61449494
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61365625
90Hippo signaling pathway_Homo sapiens_hsa043900.61341515
91Hepatitis C_Homo sapiens_hsa051600.61311687
92Endometrial cancer_Homo sapiens_hsa052130.58876183
93Bladder cancer_Homo sapiens_hsa052190.58796041
94ErbB signaling pathway_Homo sapiens_hsa040120.50864626
95Melanoma_Homo sapiens_hsa052180.50345916
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50180115
97ECM-receptor interaction_Homo sapiens_hsa045120.50058279
98Prion diseases_Homo sapiens_hsa050200.49250275
99Pancreatic secretion_Homo sapiens_hsa049720.46339560
100Mineral absorption_Homo sapiens_hsa049780.45907135
101Insulin signaling pathway_Homo sapiens_hsa049100.44235647
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40368202
103Metabolic pathways_Homo sapiens_hsa011000.39862283
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37949837
105Fructose and mannose metabolism_Homo sapiens_hsa000510.37810308
106Protein export_Homo sapiens_hsa030600.37594970
107Pentose phosphate pathway_Homo sapiens_hsa000300.36486115
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34514607
109Galactose metabolism_Homo sapiens_hsa000520.33974654
110Linoleic acid metabolism_Homo sapiens_hsa005910.33550328
111Lysine degradation_Homo sapiens_hsa003100.31101333
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30616676
113Vibrio cholerae infection_Homo sapiens_hsa051100.30557679
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28236610
115Thyroid hormone synthesis_Homo sapiens_hsa049180.25959303
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25850256
117Renin-angiotensin system_Homo sapiens_hsa046140.24929535
118Amoebiasis_Homo sapiens_hsa051460.22096632
119Vitamin B6 metabolism_Homo sapiens_hsa007500.21879735
120Tight junction_Homo sapiens_hsa045300.19685986
121Adherens junction_Homo sapiens_hsa045200.18212493
122Glucagon signaling pathway_Homo sapiens_hsa049220.17790618
123Insulin resistance_Homo sapiens_hsa049310.17355487
124Focal adhesion_Homo sapiens_hsa045100.16448361
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16074765
126Fatty acid biosynthesis_Homo sapiens_hsa000610.12468712
127Ovarian steroidogenesis_Homo sapiens_hsa049130.10983068
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.10504781
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07088695
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.04397301
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03628652
132AMPK signaling pathway_Homo sapiens_hsa041520.03150277
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02783453
134Insulin secretion_Homo sapiens_hsa049110.01944711

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