LUZP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)3.94954748
2negative regulation of keratinocyte proliferation (GO:0010839)3.83907234
3paraxial mesoderm development (GO:0048339)3.83536084
4plasma membrane repair (GO:0001778)3.83423809
5vitamin transmembrane transport (GO:0035461)3.75791309
6hippo signaling (GO:0035329)3.69174860
7DNA damage induced protein phosphorylation (GO:0006975)3.62666548
8hemidesmosome assembly (GO:0031581)3.57337628
9gap junction assembly (GO:0016264)3.52091083
10mesodermal cell differentiation (GO:0048333)3.51013682
11peptidyl-tyrosine autophosphorylation (GO:0038083)3.40162592
12negative regulation of chondrocyte differentiation (GO:0032331)3.39156355
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.34739559
14desmosome organization (GO:0002934)3.28950394
15pore complex assembly (GO:0046931)3.27987532
16axon extension involved in axon guidance (GO:0048846)3.22944758
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.22944758
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.20289246
19chromosome condensation (GO:0030261)3.17324429
20skin morphogenesis (GO:0043589)3.17294547
21retina vasculature morphogenesis in camera-type eye (GO:0061299)3.08747005
22regulation of early endosome to late endosome transport (GO:2000641)3.08306679
23cell communication involved in cardiac conduction (GO:0086065)3.07423657
24cell adhesion mediated by integrin (GO:0033627)3.04470077
25substrate-dependent cell migration (GO:0006929)3.00218970
26regulation of tight junction assembly (GO:2000810)2.97499885
27embryonic foregut morphogenesis (GO:0048617)2.97119314
28vascular endothelial growth factor signaling pathway (GO:0038084)2.95367028
29regulation of cardioblast differentiation (GO:0051890)2.90696645
30sodium ion export (GO:0071436)2.90139734
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90066812
32planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89911712
33epithelial cell-cell adhesion (GO:0090136)2.89244990
34cell migration involved in sprouting angiogenesis (GO:0002042)2.85022933
35DNA packaging (GO:0006323)2.83988217
36wound healing, spreading of cells (GO:0044319)2.83587062
37wound healing, spreading of epidermal cells (GO:0035313)2.80356485
38protein complex localization (GO:0031503)2.80207605
39cell-substrate junction assembly (GO:0007044)2.80076429
40notochord development (GO:0030903)2.79731513
41pre-miRNA processing (GO:0031054)2.79400885
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78203678
43nuclear pore complex assembly (GO:0051292)2.77790038
44protein localization to endosome (GO:0036010)2.77060294
45NLS-bearing protein import into nucleus (GO:0006607)2.76003203
46renal filtration (GO:0097205)2.75408548
47regulation of RNA export from nucleus (GO:0046831)2.75210519
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74863404
49determination of adult lifespan (GO:0008340)2.74190608
50adherens junction assembly (GO:0034333)2.73512120
51negative regulation of potassium ion transmembrane transport (GO:1901380)2.73450843
52chondrocyte proliferation (GO:0035988)2.72731726
53anterior/posterior axis specification, embryo (GO:0008595)2.71177739
54glomerular visceral epithelial cell development (GO:0072015)2.70617007
55regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68942763
56lymphangiogenesis (GO:0001946)2.67174004
57endothelium development (GO:0003158)2.66909196
58regulation of hippo signaling (GO:0035330)2.65797235
59cellular protein complex localization (GO:0034629)2.64500865
60regulation of transforming growth factor beta2 production (GO:0032909)2.63726132
61cell communication by electrical coupling (GO:0010644)2.61938966
62keratinocyte proliferation (GO:0043616)2.61344978
63negative regulation of hormone biosynthetic process (GO:0032353)2.61028780
64negative regulation of hormone metabolic process (GO:0032351)2.61028780
65mitotic chromosome condensation (GO:0007076)2.60622999
66cell junction assembly (GO:0034329)2.58498984
67regulation of histone phosphorylation (GO:0033127)2.58405833
68glomerular basement membrane development (GO:0032836)2.57549696
69positive regulation of glycoprotein biosynthetic process (GO:0010560)2.56511543
70regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.55772416
71regulation of nucleobase-containing compound transport (GO:0032239)2.55245132
72blood vessel maturation (GO:0001955)2.54984898
73vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54933838
74ventricular cardiac muscle cell action potential (GO:0086005)2.53658513
75regulation of mitotic spindle organization (GO:0060236)2.53377385
76regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.53087362
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52609366
78positive regulation of glycoprotein metabolic process (GO:1903020)2.51481201
79establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.50475939
80SMAD protein complex assembly (GO:0007183)2.49344048
81sprouting angiogenesis (GO:0002040)2.49017229
82negative regulation of DNA repair (GO:0045738)2.46563215
83mitotic metaphase plate congression (GO:0007080)2.46382837
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46093014
85atrioventricular valve morphogenesis (GO:0003181)2.45584052
86negative regulation of anoikis (GO:2000811)2.44342485
87regulation of SMAD protein import into nucleus (GO:0060390)2.43683497
88positive regulation of catenin import into nucleus (GO:0035413)2.43428145
89establishment of nucleus localization (GO:0040023)2.43389536
90dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42799703
91glomerular epithelial cell development (GO:0072310)2.42046365
92regulation of cell fate specification (GO:0042659)2.41658843
93bone trabecula formation (GO:0060346)2.40472607
94negative regulation of vascular permeability (GO:0043116)2.40124931
95basement membrane organization (GO:0071711)2.39896521
96blood vessel endothelial cell migration (GO:0043534)2.39127282
97endodermal cell differentiation (GO:0035987)2.39068787
98lung-associated mesenchyme development (GO:0060484)2.38406510
99nuclear pore organization (GO:0006999)2.38397744
100negative regulation of cell fate specification (GO:0009996)2.37944997
101mitotic sister chromatid cohesion (GO:0007064)2.37943781
102endocardial cushion development (GO:0003197)2.37267312
103heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.36193573
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.36117069
105multicellular organismal macromolecule metabolic process (GO:0044259)2.36082975
106cell junction organization (GO:0034330)2.36021552
107establishment of epithelial cell polarity (GO:0090162)2.35733885
108substrate adhesion-dependent cell spreading (GO:0034446)2.34494580
109focal adhesion assembly (GO:0048041)2.33470009
110cell-substrate adherens junction assembly (GO:0007045)2.33470009
111mitotic G1 DNA damage checkpoint (GO:0031571)2.33392324
112regulation of keratinocyte proliferation (GO:0010837)2.33171353
113collagen metabolic process (GO:0032963)2.32848855
114lymph vessel development (GO:0001945)2.32488168
115insulin-like growth factor receptor signaling pathway (GO:0048009)2.32433986
116stress fiber assembly (GO:0043149)2.31887089
117pericardium development (GO:0060039)2.30509556
118regulation of gene silencing by RNA (GO:0060966)2.29519666
119regulation of posttranscriptional gene silencing (GO:0060147)2.29519666
120regulation of gene silencing by miRNA (GO:0060964)2.29519666
121negative regulation of cartilage development (GO:0061037)2.29099942
122glomerular filtration (GO:0003094)2.28806276
123regulation of G0 to G1 transition (GO:0070316)2.28063096
124cell migration involved in gastrulation (GO:0042074)2.28027059
125polarized epithelial cell differentiation (GO:0030859)2.27530309
126response to hepatocyte growth factor (GO:0035728)2.27510525
127cellular response to hepatocyte growth factor stimulus (GO:0035729)2.27510525
128regulation of clathrin-mediated endocytosis (GO:2000369)2.26779832
129protein retention in ER lumen (GO:0006621)2.26714426
130fibroblast migration (GO:0010761)2.26512274
131collagen fibril organization (GO:0030199)2.26341461
132endothelial cell morphogenesis (GO:0001886)2.26280748
133branching involved in salivary gland morphogenesis (GO:0060445)2.26248536
134semaphorin-plexin signaling pathway (GO:0071526)2.26051044
135regulation of p38MAPK cascade (GO:1900744)2.25704189
136dorsal/ventral axis specification (GO:0009950)2.24917487
137multicellular organismal metabolic process (GO:0044236)2.24221610
138cardiac myofibril assembly (GO:0055003)2.23900653
139hypotonic response (GO:0006971)2.22222843
140heterochromatin organization (GO:0070828)2.20786102
141establishment of apical/basal cell polarity (GO:0035089)2.20549970
142apoptotic cell clearance (GO:0043277)2.20382719
143cellular potassium ion homeostasis (GO:0030007)2.20141038
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.19447790
145adherens junction organization (GO:0034332)2.19402716
146gastrulation with mouth forming second (GO:0001702)2.17794264
147negative regulation of catenin import into nucleus (GO:0035414)2.17675881
148regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.17485525
149regulation of protein polyubiquitination (GO:1902914)2.16209861
150intestinal epithelial cell development (GO:0060576)2.15964360
151protein targeting to plasma membrane (GO:0072661)2.15584803
152positive regulation of p38MAPK cascade (GO:1900745)2.15151457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.83982956
2E2F7_22180533_ChIP-Seq_HELA_Human4.51733990
3NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.57181642
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55197147
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.49510036
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.21631944
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14456035
8ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.13268208
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.06327968
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96988094
11GATA2_21666600_ChIP-Seq_HMVEC_Human1.93800823
12WT1_19549856_ChIP-ChIP_CCG9911_Human1.91158542
13EGR1_19374776_ChIP-ChIP_THP-1_Human1.90445306
14EP300_21415370_ChIP-Seq_HL-1_Mouse1.90230253
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87164986
16* UBF1/2_26484160_Chip-Seq_HMECs_Human1.86623525
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77747806
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.76397499
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73796701
20CLOCK_20551151_ChIP-Seq_293T_Human1.73265249
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71384429
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66686756
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66524442
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.65970921
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59378217
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58645569
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57986704
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.54954396
29* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53506133
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52600341
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51274109
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.48746919
33CJUN_26792858_Chip-Seq_BT549_Human1.48380575
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47449518
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46310088
36TP53_16413492_ChIP-PET_HCT116_Human1.44947639
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.44798714
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44255342
39EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.43023948
40TP53_22127205_ChIP-Seq_IMR90_Human1.43001702
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39074606
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39074606
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39011868
44AR_21909140_ChIP-Seq_LNCAP_Human1.38536860
45ZNF274_21170338_ChIP-Seq_K562_Hela1.38391722
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37013675
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36455890
48* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35488529
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.34568185
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32825042
51* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32182797
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31197545
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29928851
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28857356
55ATF3_27146783_Chip-Seq_COLON_Human1.28702009
56BRD4_25478319_ChIP-Seq_HGPS_Human1.26902889
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.24708497
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24156103
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23369103
60* KDM2B_26808549_Chip-Seq_K562_Human1.21900661
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21140062
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20702173
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.20295043
64ZNF263_19887448_ChIP-Seq_K562_Human1.19127280
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18801115
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18354307
67AHR_22903824_ChIP-Seq_MCF-7_Human1.18238787
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17844951
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.17111494
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16349719
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15265591
72KLF5_25053715_ChIP-Seq_YYC3_Human1.14405942
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13967340
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.13814360
75* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13282503
76* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12351212
77* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12066957
78* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11859537
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.11811829
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10925686
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10654685
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09520320
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09001042
84* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08936981
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08821930
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.08253088
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07432086
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07432086
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07432086
90TP53_23651856_ChIP-Seq_MEFs_Mouse1.07421060
91GATA6_25053715_ChIP-Seq_YYC3_Human1.07380271
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07321077
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07291445
94SOX2_20726797_ChIP-Seq_SW620_Human1.06947246
95* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05946829
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05625859
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04938539
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04901922
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03754838
100* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03636870
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.03382160
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.03382160
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02903290
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02903290
105TP63_23658742_ChIP-Seq_EP156T_Human1.02499714
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99891332
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99062094
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98203720
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98203720
110E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98191507
111* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98065326
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97471241
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.97154846
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96701721
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96579140
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95784418
117* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95699614
118TP63_19390658_ChIP-ChIP_HaCaT_Human0.95071847
119CHD1_26751641_Chip-Seq_LNCaP_Human0.94522370
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94496585
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94367737
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93972097
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93710583
124DROSHA_22980978_ChIP-Seq_HELA_Human0.93211817
125* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93106189
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92376712
127RNF2_27304074_Chip-Seq_ESCs_Mouse0.90900291
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90697939
129RACK7_27058665_Chip-Seq_MCF-7_Human0.90125386
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89788507
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.89113850
132TP53_18474530_ChIP-ChIP_U2OS_Human0.88216064
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88050650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure4.03925359
2MP0003705_abnormal_hypodermis_morpholog4.03473228
3MP0010234_abnormal_vibrissa_follicle3.99875072
4MP0005623_abnormal_meninges_morphology2.88184214
5MP0003941_abnormal_skin_development2.74945958
6MP0004272_abnormal_basement_membrane2.68920129
7MP0000579_abnormal_nail_morphology2.60070616
8MP0008438_abnormal_cutaneous_collagen2.54778371
9MP0005377_hearing/vestibular/ear_phenot2.50962514
10MP0003878_abnormal_ear_physiology2.50962514
11MP0005275_abnormal_skin_tensile2.49269214
12MP0005076_abnormal_cell_differentiation2.46191082
13MP0010352_gastrointestinal_tract_polyps2.33525026
14MP0000537_abnormal_urethra_morphology2.25720523
15MP0005409_darkened_coat_color2.22973030
16MP0003566_abnormal_cell_adhesion2.12546381
17MP0005167_abnormal_blood-brain_barrier2.10939904
18MP0009053_abnormal_anal_canal2.06034337
19MP0004084_abnormal_cardiac_muscle2.04541288
20MP0000762_abnormal_tongue_morphology1.99854192
21MP0003123_paternal_imprinting1.92672625
22MP0010368_abnormal_lymphatic_system1.86703951
23MP0005503_abnormal_tendon_morphology1.82288872
24MP0004957_abnormal_blastocyst_morpholog1.69088327
25MP0010030_abnormal_orbit_morphology1.68035336
26MP0005670_abnormal_white_adipose1.62563412
27MP0003950_abnormal_plasma_membrane1.61822728
28MP0004185_abnormal_adipocyte_glucose1.61710958
29MP0000013_abnormal_adipose_tissue1.56643850
30MP0000467_abnormal_esophagus_morphology1.54811214
31MP0004233_abnormal_muscle_weight1.54126711
32MP0001849_ear_inflammation1.49299995
33MP0000534_abnormal_ureter_morphology1.43231613
34MP0000733_abnormal_muscle_development1.42063967
35MP0003091_abnormal_cell_migration1.39452908
36MP0006138_congestive_heart_failure1.37607079
37MP0003283_abnormal_digestive_organ1.36986180
38MP0000751_myopathy1.36831580
39MP0005023_abnormal_wound_healing1.36558068
40MP0002822_catalepsy1.36401967
41* MP0003385_abnormal_body_wall1.36210557
42MP0003279_aneurysm1.34913058
43MP0004264_abnormal_extraembryonic_tissu1.31803280
44MP0008932_abnormal_embryonic_tissue1.30796192
45MP0005501_abnormal_skin_physiology1.28283487
46MP0003045_fibrosis1.26768207
47MP0003115_abnormal_respiratory_system1.25960205
48MP0000678_abnormal_parathyroid_gland1.24618051
49MP0003111_abnormal_nucleus_morphology1.24329384
50MP0009697_abnormal_copulation1.24144971
51MP0010678_abnormal_skin_adnexa1.21710353
52MP0005187_abnormal_penis_morphology1.21201495
53MP0003693_abnormal_embryo_hatching1.20693716
54MP0002697_abnormal_eye_size1.19164885
55MP0008007_abnormal_cellular_replicative1.18307038
56MP0006054_spinal_hemorrhage1.16443976
57MP0003077_abnormal_cell_cycle1.15131935
58MP0001879_abnormal_lymphatic_vessel1.14642556
59MP0002060_abnormal_skin_morphology1.14056818
60MP0004484_altered_response_of1.13330582
61MP0009384_cardiac_valve_regurgitation1.12943333
62MP0002925_abnormal_cardiovascular_devel1.11697353
63MP0002796_impaired_skin_barrier1.11688161
64MP0009780_abnormal_chondrocyte_physiolo1.11265869
65MP0001915_intracranial_hemorrhage1.09690122
66MP0000516_abnormal_urinary_system1.09568529
67MP0005367_renal/urinary_system_phenotyp1.09568529
68MP0003937_abnormal_limbs/digits/tail_de1.07469600
69MP0008057_abnormal_DNA_replication1.07179806
70MP0005410_abnormal_fertilization1.05607525
71MP0001216_abnormal_epidermal_layer1.04811918
72MP0010630_abnormal_cardiac_muscle1.04041780
73MP0002086_abnormal_extraembryonic_tissu1.03884037
74MP0002234_abnormal_pharynx_morphology1.03722400
75MP0004215_abnormal_myocardial_fiber1.02971798
76MP0009672_abnormal_birth_weight1.01699170
77MP0001299_abnormal_eye_distance/1.01289254
78MP0003984_embryonic_growth_retardation0.99558393
79MP0002088_abnormal_embryonic_growth/wei0.98203327
80MP0002084_abnormal_developmental_patter0.97886274
81MP0003119_abnormal_digestive_system0.97704760
82MP0005197_abnormal_uvea_morphology0.97513000
83MP0004087_abnormal_muscle_fiber0.97158387
84MP0000767_abnormal_smooth_muscle0.97095540
85MP0001348_abnormal_lacrimal_gland0.97047235
86MP0004859_abnormal_synaptic_plasticity0.96615905
87MP0005380_embryogenesis_phenotype0.95226723
88MP0001672_abnormal_embryogenesis/_devel0.95226723
89MP0003315_abnormal_perineum_morphology0.95022112
90MP0010307_abnormal_tumor_latency0.94691272
91MP0000428_abnormal_craniofacial_morphol0.94602276
92* MP0003935_abnormal_craniofacial_develop0.94317196
93MP0002089_abnormal_postnatal_growth/wei0.93926542
94MP0008775_abnormal_heart_ventricle0.93376453
95MP0005666_abnormal_adipose_tissue0.93340631
96* MP0002080_prenatal_lethality0.92788305
97MP0003828_pulmonary_edema0.92378355
98MP0005248_abnormal_Harderian_gland0.91936161
99MP0000003_abnormal_adipose_tissue0.91147196
100MP0004197_abnormal_fetal_growth/weight/0.90743158
101MP0000750_abnormal_muscle_regeneration0.89383029
102MP0010771_integument_phenotype0.89114783
103MP0000432_abnormal_head_morphology0.89069165
104MP0001958_emphysema0.88911679
105MP0009250_abnormal_appendicular_skeleto0.88867565
106MP0002896_abnormal_bone_mineralization0.87332736
107MP0001730_embryonic_growth_arrest0.86569302
108MP0001697_abnormal_embryo_size0.85964027
109* MP0002085_abnormal_embryonic_tissue0.84891327
110* MP0003755_abnormal_palate_morphology0.84369542
111MP0005595_abnormal_vascular_smooth0.84182079
112MP0005621_abnormal_cell_physiology0.84062937
113MP0002295_abnormal_pulmonary_circulatio0.84020463
114MP0004036_abnormal_muscle_relaxation0.83937588
115MP0002254_reproductive_system_inflammat0.83895008
116MP0003300_gastrointestinal_ulcer0.83336103
117MP0000383_abnormal_hair_follicle0.82885661
118MP0002111_abnormal_tail_morphology0.80384936
119MP0000569_abnormal_digit_pigmentation0.80043042
120MP0003718_maternal_effect0.79558318
121MP0002108_abnormal_muscle_morphology0.79256615
122MP0001614_abnormal_blood_vessel0.79168026
123MP0005508_abnormal_skeleton_morphology0.79103627
124MP0002282_abnormal_trachea_morphology0.78222736
125MP0000350_abnormal_cell_proliferation0.78109446
126MP0002877_abnormal_melanocyte_morpholog0.77577825
127MP0001544_abnormal_cardiovascular_syste0.77165098
128MP0005385_cardiovascular_system_phenoty0.77165098
129MP0002972_abnormal_cardiac_muscle0.76812103
130MP0003453_abnormal_keratinocyte_physiol0.76641288
131MP0002092_abnormal_eye_morphology0.76164485
132MP0010094_abnormal_chromosome_stability0.75389865
133MP0000627_abnormal_mammary_gland0.74309389
134MP0002098_abnormal_vibrissa_morphology0.74002317
135MP0005360_urolithiasis0.72780710

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.65974191
2Shallow orbits (HP:0000586)3.66076365
3Protrusio acetabuli (HP:0003179)3.61563525
4Prostate neoplasm (HP:0100787)3.58971650
5Premature rupture of membranes (HP:0001788)3.15718397
6Atrophic scars (HP:0001075)3.01070461
7Fragile nails (HP:0001808)2.89645693
8Ankyloglossia (HP:0010296)2.80145653
9Increased connective tissue (HP:0009025)2.77331373
10Natal tooth (HP:0000695)2.77292280
11Cerebral aneurysm (HP:0004944)2.70478045
12Abnormality of oral frenula (HP:0000190)2.63930603
13Ankle contracture (HP:0006466)2.63444002
14Onycholysis (HP:0001806)2.58151605
15Difficulty climbing stairs (HP:0003551)2.56617699
16Broad metatarsal (HP:0001783)2.55094280
17Aortic aneurysm (HP:0004942)2.52920961
18Malnutrition (HP:0004395)2.52000222
19Thick nail (HP:0001805)2.50204016
20Ventricular tachycardia (HP:0004756)2.43589714
21Urethral obstruction (HP:0000796)2.38121514
22Wormian bones (HP:0002645)2.35881827
23Shawl scrotum (HP:0000049)2.35479936
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.33250901
25Osteolytic defects of the hand bones (HP:0009699)2.33250901
26Aortic dissection (HP:0002647)2.31518516
27Ulnar bowing (HP:0003031)2.30618520
28Broad face (HP:0000283)2.30220491
29Abnormality of nail color (HP:0100643)2.30215247
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29810637
31Short 4th metacarpal (HP:0010044)2.29810637
32Spinal cord lesions (HP:0100561)2.28431891
33Syringomyelia (HP:0003396)2.28431891
34Advanced eruption of teeth (HP:0006288)2.26663167
35Dilatation of the ascending aorta (HP:0005111)2.17977307
36Plantar hyperkeratosis (HP:0007556)2.16426620
37Hyporeflexia of lower limbs (HP:0002600)2.10805607
38Fragile skin (HP:0001030)2.10415003
39Wrist flexion contracture (HP:0001239)2.10146814
40Milia (HP:0001056)2.09956528
41Action tremor (HP:0002345)2.09428991
42Vertebral arch anomaly (HP:0008438)2.09098041
43Mitral valve prolapse (HP:0001634)2.07604677
44Subacute progressive viral hepatitis (HP:0006572)2.05641942
45Aplasia cutis congenita (HP:0001057)2.04396120
46Joint laxity (HP:0001388)2.04044876
47Oligomenorrhea (HP:0000876)2.03175206
48Bladder diverticulum (HP:0000015)2.02746295
49Bundle branch block (HP:0011710)2.02465234
50Genu recurvatum (HP:0002816)2.01972611
51Spondylolisthesis (HP:0003302)2.00986953
52Aneurysm (HP:0002617)1.99567759
53Vertebral clefting (HP:0008428)1.99013322
54Pterygium (HP:0001059)1.98290244
55Biliary tract neoplasm (HP:0100574)1.95557174
56Ventricular fibrillation (HP:0001663)1.95179310
57Hip contracture (HP:0003273)1.93282003
58Abnormality of the acetabulum (HP:0003170)1.93198433
59Enlarged penis (HP:0000040)1.92403052
60Lower limb amyotrophy (HP:0007210)1.92334159
61Sudden death (HP:0001699)1.91476592
62Abnormality of dentin (HP:0010299)1.91103226
63Distal lower limb amyotrophy (HP:0008944)1.90151602
64Abnormality of the distal phalanx of the thumb (HP:0009617)1.89562553
65Vascular tortuosity (HP:0004948)1.88322837
66Neonatal short-limb short stature (HP:0008921)1.88170697
67Spinal rigidity (HP:0003306)1.87960986
68Flat acetabular roof (HP:0003180)1.86588023
69Trismus (HP:0000211)1.84266723
70Thin bony cortex (HP:0002753)1.83921005
71Abnormality of the 4th metacarpal (HP:0010012)1.83877057
72Toxemia of pregnancy (HP:0100603)1.83053249
73Polygenic inheritance (HP:0010982)1.81984076
74Blue sclerae (HP:0000592)1.80718895
75Distal upper limb amyotrophy (HP:0007149)1.80325785
76Upper limb amyotrophy (HP:0009129)1.80325785
77Follicular hyperkeratosis (HP:0007502)1.78802152
78Arterial tortuosity (HP:0005116)1.78099117
79Mildly elevated creatine phosphokinase (HP:0008180)1.77283788
80Nail dystrophy (HP:0008404)1.77179675
81Disproportionate tall stature (HP:0001519)1.77002330
82Focal segmental glomerulosclerosis (HP:0000097)1.76740211
83Muscle fiber splitting (HP:0003555)1.76158898
84Scapular winging (HP:0003691)1.74985212
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74568685
86Abnormal ossification of hand bones (HP:0005921)1.73995955
87Rectal prolapse (HP:0002035)1.73897923
88Bowel diverticulosis (HP:0005222)1.73632154
89Long palpebral fissure (HP:0000637)1.73341772
90Difficulty running (HP:0009046)1.72065781
91Hematochezia (HP:0002573)1.72022451
92Renal duplication (HP:0000075)1.71623883
93Alopecia of scalp (HP:0002293)1.71472547
94Ectopia lentis (HP:0001083)1.70287073
95Short nail (HP:0001799)1.70130538
96Ventricular arrhythmia (HP:0004308)1.70046085
97Broad thumb (HP:0011304)1.69526887
98Coronal craniosynostosis (HP:0004440)1.69418685
99Mitral regurgitation (HP:0001653)1.69184441
100Dysmetric saccades (HP:0000641)1.68945288
101Ridged nail (HP:0001807)1.68652334
102Arnold-Chiari malformation (HP:0002308)1.67901834
103Relative macrocephaly (HP:0004482)1.67833849
104Deviation of the thumb (HP:0009603)1.67087578
105Overgrowth (HP:0001548)1.65419989
106Spinal cord compression (HP:0002176)1.65062402
107Limited hip movement (HP:0008800)1.64674593
108Abnormality of carpal bone ossification (HP:0006257)1.63970469
109Hyperextensible skin (HP:0000974)1.63915017
110Abnormality of the nasal septum (HP:0000419)1.63850251
111Short humerus (HP:0005792)1.63740411
112Absent frontal sinuses (HP:0002688)1.63362133
113Spastic diplegia (HP:0001264)1.60754753
114Hyperacusis (HP:0010780)1.59685851
115Narrow palate (HP:0000189)1.58819154
116Venous abnormality (HP:0002624)1.57831357
117Hypoplastic toenails (HP:0001800)1.57809644
118Male infertility (HP:0003251)1.57602331
119Hypoplasia of dental enamel (HP:0006297)1.57481237
120Pulmonic stenosis (HP:0001642)1.57458585
121Supernumerary nipples (HP:0002558)1.57452507
122Cervical subluxation (HP:0003308)1.56556179
123Deviation of the hallux (HP:0010051)1.55840061
124Hand muscle atrophy (HP:0009130)1.55662636
125Abnormality of the lower motor neuron (HP:0002366)1.55563895
126Short hallux (HP:0010109)1.54296653
127Aplasia of the phalanges of the hand (HP:0009802)1.54173029
128Aplasia involving bones of the extremities (HP:0009825)1.54173029
129Aplasia involving bones of the upper limbs (HP:0009823)1.54173029
130Pili torti (HP:0003777)1.54087880
131Camptodactyly of toe (HP:0001836)1.53923395
132Skull defect (HP:0001362)1.53322983
133Broad long bones (HP:0005622)1.53223536
134Short 1st metacarpal (HP:0010034)1.52823260
135Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.52823260
136Sparse scalp hair (HP:0002209)1.52139390
137Absent eyelashes (HP:0000561)1.52094872
138Neonatal death (HP:0003811)1.51633239
139Protruding ear (HP:0000411)1.51552836
140Vertebral compression fractures (HP:0002953)1.50816203
141Selective tooth agenesis (HP:0001592)1.50363626
142Soft skin (HP:0000977)1.49983485
143Hypoalphalipoproteinemia (HP:0003233)1.49876830
144Malignant gastrointestinal tract tumors (HP:0006749)1.49036534
145Gastrointestinal carcinoma (HP:0002672)1.49036534
146Broad finger (HP:0001500)1.48459791
147Broad phalanges of the hand (HP:0009768)1.47263506
148Woolly hair (HP:0002224)1.46800013
149Laryngomalacia (HP:0001601)1.46706290
150Proximal placement of thumb (HP:0009623)1.46520204
151Long eyelashes (HP:0000527)1.46134196
152Abnormal vertebral ossification (HP:0100569)1.45577553
153Broad phalanx (HP:0006009)1.45401885
154Bronchomalacia (HP:0002780)1.45307156
155Hypoplastic ischia (HP:0003175)1.45252410
156Abnormal hand bone ossification (HP:0010660)1.44830493
157Hypoplasia of the iris (HP:0007676)1.44266723
158Persistence of primary teeth (HP:0006335)1.44174025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.90478578
2PIK3CA4.82469254
3KSR23.76747963
4MAP3K23.62499608
5MET3.19078384
6LATS12.95406416
7BRD42.67865726
8LATS22.55911170
9RIPK12.38252619
10MAP3K102.22400949
11FLT31.96696119
12PRKD31.91897819
13PLK41.72835462
14EPHA21.70329665
15PDK41.66962163
16PDK31.66962163
17TTN1.59615283
18PDK21.59127517
19MYLK1.52823453
20MAP2K11.52501936
21STK38L1.50509272
22FRK1.48818787
23STK381.46093086
24FER1.42860127
25DMPK1.35794483
26CDK121.34301415
27LMTK21.33527013
28TGFBR21.32807520
29PDGFRA1.31208232
30MAP2K21.30206078
31EPHB21.27479632
32RET1.22804726
33BRSK21.21891499
34WNK11.21043391
35DDR21.17560101
36ARAF1.17338545
37TRIB31.14468216
38MAP3K91.11581071
39SMG11.10541069
40PTK2B1.10092174
41NEK11.09372033
42TIE11.04421467
43TNIK1.03407153
44TGFBR11.02592655
45PTK20.98270700
46TESK10.97620113
47STK30.96939368
48PKN20.96513507
49NME10.96123477
50BMX0.95003096
51TTK0.92375434
52MAP3K80.87799273
53EEF2K0.86640773
54PBK0.85727535
55MAP3K10.85440567
56PTK60.84851537
57CDK90.84283305
58BUB10.83253125
59ACVR1B0.82551430
60AKT30.81354049
61PAK40.81320387
62PAK60.79899885
63BRAF0.79435099
64CDK70.76328062
65CAMK1D0.74522213
66MTOR0.73709926
67CDK80.71762592
68MKNK20.71354711
69TSSK60.71092697
70CHEK10.70741768
71CAMK1G0.70155895
72MAP3K120.67790572
73FGFR10.67551045
74TAOK10.67235905
75KDR0.66368916
76RPS6KA20.65499693
77CAMKK10.65433744
78STK240.63189391
79PAK20.61892326
80PRPF4B0.61411033
81ALK0.60125897
82TAF10.59531927
83MAPKAPK30.58318414
84NTRK30.58310268
85MELK0.57687494
86MKNK10.57023045
87TYRO30.56316409
88ROCK20.56046206
89PDGFRB0.55773228
90PAK30.55744156
91MINK10.55260111
92STK100.52409596
93NUAK10.52090406
94SRPK10.51640930
95BRSK10.48179777
96ROCK10.48164559
97PLK10.47784690
98MAP3K40.47043931
99SCYL20.46983727
100EPHA30.46415563
101CDK60.46279349
102NEK20.45881099
103ERBB40.45861782
104PLK20.44952529
105KSR10.43534951
106PNCK0.43052227
107PLK30.41767967
108CAMK2D0.40876222
109ZAK0.40514351
110CDC70.39809176
111NEK90.39343042
112PRKG20.39100078
113RPS6KB20.38072976
114DAPK30.37891641
115MAPK100.36657717
116PIK3CG0.36647047
117CDK20.36007918
118CDK10.34936822
119MAP3K30.33942969
120ICK0.33659937
121ABL20.31787097
122TRPM70.31760291
123ERBB20.31131062
124CDC42BPA0.29777980
125AURKB0.29750722
126PAK10.29719068
127PRKD20.29032269
128SIK10.27608039
129FGFR20.26749541
130EPHA40.25712763
131CSNK1E0.24208788
132FGFR30.23987402
133SRC0.21506834
134MOS0.20545648
135CHEK20.20353835
136SGK30.19298477
137NTRK10.19210831
138PDPK10.18995795
139ATM0.18547115

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049782.66607819
2Adherens junction_Homo sapiens_hsa045202.35684251
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12869042
4Dorso-ventral axis formation_Homo sapiens_hsa043202.08049814
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.05521738
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.95682012
7ECM-receptor interaction_Homo sapiens_hsa045121.81509277
8Hippo signaling pathway_Homo sapiens_hsa043901.68873072
9Focal adhesion_Homo sapiens_hsa045101.68595091
10Tight junction_Homo sapiens_hsa045301.68458668
11Thyroid cancer_Homo sapiens_hsa052161.66744628
12Proteoglycans in cancer_Homo sapiens_hsa052051.66480495
13Dilated cardiomyopathy_Homo sapiens_hsa054141.65038345
14Bladder cancer_Homo sapiens_hsa052191.61152147
15Cell cycle_Homo sapiens_hsa041101.57343614
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56713389
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.54719372
18Salivary secretion_Homo sapiens_hsa049701.53749720
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52058164
20Bile secretion_Homo sapiens_hsa049761.48603674
21TGF-beta signaling pathway_Homo sapiens_hsa043501.48581925
22Long-term potentiation_Homo sapiens_hsa047201.37708032
23Protein digestion and absorption_Homo sapiens_hsa049741.33590310
24Glioma_Homo sapiens_hsa052141.32676402
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32227961
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30591365
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.27189774
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26779780
29Oocyte meiosis_Homo sapiens_hsa041141.25740201
30MicroRNAs in cancer_Homo sapiens_hsa052061.25479119
31Type II diabetes mellitus_Homo sapiens_hsa049301.25295311
32mTOR signaling pathway_Homo sapiens_hsa041501.23726796
33RNA transport_Homo sapiens_hsa030131.22185430
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20971899
35Estrogen signaling pathway_Homo sapiens_hsa049151.20898885
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20621543
37Melanogenesis_Homo sapiens_hsa049161.20574381
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20375999
39Basal cell carcinoma_Homo sapiens_hsa052171.19787980
40Lysine degradation_Homo sapiens_hsa003101.16338134
41Non-homologous end-joining_Homo sapiens_hsa034501.15401040
42GnRH signaling pathway_Homo sapiens_hsa049121.15393716
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14076686
44mRNA surveillance pathway_Homo sapiens_hsa030151.13991916
45HIF-1 signaling pathway_Homo sapiens_hsa040661.12934731
46Gap junction_Homo sapiens_hsa045401.11790119
47Endometrial cancer_Homo sapiens_hsa052131.11569511
48Melanoma_Homo sapiens_hsa052181.11038856
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09821387
50Small cell lung cancer_Homo sapiens_hsa052221.08539479
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06446735
52Oxytocin signaling pathway_Homo sapiens_hsa049211.06302084
53Hedgehog signaling pathway_Homo sapiens_hsa043401.06067474
54Amoebiasis_Homo sapiens_hsa051461.04381688
55Rap1 signaling pathway_Homo sapiens_hsa040151.03750735
56Gastric acid secretion_Homo sapiens_hsa049710.99789720
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99073611
58Chronic myeloid leukemia_Homo sapiens_hsa052200.98217103
59Circadian entrainment_Homo sapiens_hsa047130.97647039
60Axon guidance_Homo sapiens_hsa043600.97392279
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97311896
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94954610
63Renal cell carcinoma_Homo sapiens_hsa052110.94931557
64VEGF signaling pathway_Homo sapiens_hsa043700.94828315
65Fatty acid biosynthesis_Homo sapiens_hsa000610.92707132
66ErbB signaling pathway_Homo sapiens_hsa040120.90653383
67DNA replication_Homo sapiens_hsa030300.90035302
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.89858575
69Inositol phosphate metabolism_Homo sapiens_hsa005620.85848070
70Salmonella infection_Homo sapiens_hsa051320.85544387
71Renin-angiotensin system_Homo sapiens_hsa046140.84844786
72Long-term depression_Homo sapiens_hsa047300.82702249
73Prostate cancer_Homo sapiens_hsa052150.79763492
74Renin secretion_Homo sapiens_hsa049240.79528515
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.79099718
76cAMP signaling pathway_Homo sapiens_hsa040240.77760855
77Pathways in cancer_Homo sapiens_hsa052000.77606556
78Pancreatic cancer_Homo sapiens_hsa052120.76983819
79Colorectal cancer_Homo sapiens_hsa052100.76470424
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76235193
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75204338
82Spliceosome_Homo sapiens_hsa030400.74802554
83Galactose metabolism_Homo sapiens_hsa000520.73979008
84Glucagon signaling pathway_Homo sapiens_hsa049220.73228113
85Thyroid hormone synthesis_Homo sapiens_hsa049180.72104761
86Wnt signaling pathway_Homo sapiens_hsa043100.71885037
87Selenocompound metabolism_Homo sapiens_hsa004500.71274611
88Choline metabolism in cancer_Homo sapiens_hsa052310.70747754
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69918403
90Notch signaling pathway_Homo sapiens_hsa043300.68614482
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.68236192
92Platelet activation_Homo sapiens_hsa046110.68124901
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68035091
94Amphetamine addiction_Homo sapiens_hsa050310.66797098
95Insulin secretion_Homo sapiens_hsa049110.66149335
96Non-small cell lung cancer_Homo sapiens_hsa052230.65242125
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61973601
98Cholinergic synapse_Homo sapiens_hsa047250.61969665
99Prion diseases_Homo sapiens_hsa050200.61073476
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60959939
101Synaptic vesicle cycle_Homo sapiens_hsa047210.60922094
102Insulin signaling pathway_Homo sapiens_hsa049100.60503710
103Toxoplasmosis_Homo sapiens_hsa051450.59903647
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59820247
105FoxO signaling pathway_Homo sapiens_hsa040680.58751683
106p53 signaling pathway_Homo sapiens_hsa041150.57805627
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57386501
108Vitamin digestion and absorption_Homo sapiens_hsa049770.56979561
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.56772813
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56252969
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56035843
112Pancreatic secretion_Homo sapiens_hsa049720.55715667
113Endocytosis_Homo sapiens_hsa041440.55591822
114Glutamatergic synapse_Homo sapiens_hsa047240.55439145
115Acute myeloid leukemia_Homo sapiens_hsa052210.54268712
116Viral myocarditis_Homo sapiens_hsa054160.54019958
117Fat digestion and absorption_Homo sapiens_hsa049750.53142191
118Shigellosis_Homo sapiens_hsa051310.53027645
119Nucleotide excision repair_Homo sapiens_hsa034200.52995458
120MAPK signaling pathway_Homo sapiens_hsa040100.52343965
121Mismatch repair_Homo sapiens_hsa034300.52028488
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48022617
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46371597
124Sphingolipid metabolism_Homo sapiens_hsa006000.43869043
125Biosynthesis of amino acids_Homo sapiens_hsa012300.40256614
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39837483
127Viral carcinogenesis_Homo sapiens_hsa052030.39427870
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.38052297
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36937173

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