LUZP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.25264915
2L-amino acid import (GO:0043092)5.21786210
3neuron cell-cell adhesion (GO:0007158)4.93765831
4pyrimidine nucleobase catabolic process (GO:0006208)4.93089038
5amino acid import (GO:0043090)4.91691338
6gamma-aminobutyric acid transport (GO:0015812)4.81882853
7C4-dicarboxylate transport (GO:0015740)4.64046164
8neuronal action potential propagation (GO:0019227)4.43173736
9axon ensheathment in central nervous system (GO:0032291)4.33849028
10central nervous system myelination (GO:0022010)4.33849028
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.32060674
12vocalization behavior (GO:0071625)4.30563501
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.28903116
14alanine transport (GO:0032328)4.19236699
15transmission of nerve impulse (GO:0019226)4.16741790
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.09684176
17nonmotile primary cilium assembly (GO:0035058)4.08238909
18glutamate receptor signaling pathway (GO:0007215)4.04448585
19nucleobase catabolic process (GO:0046113)4.02828729
20synaptic vesicle exocytosis (GO:0016079)4.00121748
21presynaptic membrane assembly (GO:0097105)3.98028561
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96247745
23neurotransmitter-gated ion channel clustering (GO:0072578)3.94261841
24glutamate secretion (GO:0014047)3.93773493
25cellular potassium ion homeostasis (GO:0030007)3.93510967
26cerebellar granule cell differentiation (GO:0021707)3.90896527
27synaptic vesicle maturation (GO:0016188)3.89101644
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.85827162
29synaptic transmission, glutamatergic (GO:0035249)3.84500855
30L-serine transport (GO:0015825)3.82994154
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82861998
32regulation of synaptic vesicle exocytosis (GO:2000300)3.82440824
33exploration behavior (GO:0035640)3.78142125
34proline transport (GO:0015824)3.76002207
35presynaptic membrane organization (GO:0097090)3.67354153
36regulation of glutamate receptor signaling pathway (GO:1900449)3.65755859
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.64527677
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.62625875
39response to auditory stimulus (GO:0010996)3.57642489
40protein localization to synapse (GO:0035418)3.54324127
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.52407100
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49559691
43neuron-neuron synaptic transmission (GO:0007270)3.49370675
44dermatan sulfate biosynthetic process (GO:0030208)3.48760646
45auditory behavior (GO:0031223)3.48669284
46acidic amino acid transport (GO:0015800)3.47849167
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47002734
48righting reflex (GO:0060013)3.46736376
49neurotransmitter secretion (GO:0007269)3.43508963
50positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42056144
51sodium ion export (GO:0071436)3.40037499
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38819869
53regulation of neuronal synaptic plasticity (GO:0048168)3.35484298
54dendritic spine morphogenesis (GO:0060997)3.33630927
55long-term memory (GO:0007616)3.33244449
56long-term synaptic potentiation (GO:0060291)3.31268253
57neurotransmitter uptake (GO:0001504)3.30834735
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29564041
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.27720448
60regulation of synaptic vesicle transport (GO:1902803)3.27694365
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.25449884
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.24605831
63postsynaptic membrane organization (GO:0001941)3.23871815
64dendrite morphogenesis (GO:0048813)3.22939177
65serine transport (GO:0032329)3.22324712
66layer formation in cerebral cortex (GO:0021819)3.22271414
67behavioral response to nicotine (GO:0035095)3.21746576
68negative regulation of neurotransmitter transport (GO:0051589)3.21427169
69neuron recognition (GO:0008038)3.20736907
70regulation of respiratory system process (GO:0044065)3.18194673
71myelination (GO:0042552)3.15230226
72neuronal ion channel clustering (GO:0045161)3.13500232
73cell communication by electrical coupling (GO:0010644)3.13024494
74dermatan sulfate metabolic process (GO:0030205)3.12412364
75auditory receptor cell stereocilium organization (GO:0060088)3.11566949
76neuronal action potential (GO:0019228)3.10597170
77central nervous system projection neuron axonogenesis (GO:0021952)3.09695021
78L-glutamate transport (GO:0015813)3.08906907
79axon ensheathment (GO:0008366)3.07491732
80ensheathment of neurons (GO:0007272)3.07491732
81positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.07196681
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07123140
83neurotransmitter transport (GO:0006836)3.05769411
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03939655
85positive regulation of membrane potential (GO:0045838)3.03693049
86adult walking behavior (GO:0007628)3.03507308
87potassium ion import (GO:0010107)3.03389211
88negative regulation of neurotransmitter secretion (GO:0046929)3.01000628
89positive regulation of oligodendrocyte differentiation (GO:0048714)2.99271540
90axonal fasciculation (GO:0007413)2.98218762
91reflex (GO:0060004)2.97308390
92limb bud formation (GO:0060174)2.96595633
93regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96447578
94inner ear receptor stereocilium organization (GO:0060122)2.96392835
95regulation of synaptic plasticity (GO:0048167)2.93369001
96regulation of synapse structural plasticity (GO:0051823)2.92437238
97membrane depolarization during action potential (GO:0086010)2.90763416
98neuromuscular process controlling balance (GO:0050885)2.88067995
99regulation of neurotransmitter levels (GO:0001505)2.87785460
100negative regulation of astrocyte differentiation (GO:0048712)2.85756592
101eye photoreceptor cell differentiation (GO:0001754)2.85193734
102photoreceptor cell differentiation (GO:0046530)2.85193734
103mechanosensory behavior (GO:0007638)2.83797141
104oligodendrocyte differentiation (GO:0048709)2.82918049
105positive regulation of synapse assembly (GO:0051965)2.82663709
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81367956
107startle response (GO:0001964)2.80988896
108cerebral cortex radially oriented cell migration (GO:0021799)2.80251489
109synapse assembly (GO:0007416)2.79595521
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77577624
111protein polyglutamylation (GO:0018095)2.77139870
112fatty acid elongation (GO:0030497)2.75993274
113regulation of postsynaptic membrane potential (GO:0060078)2.75436589
114potassium ion homeostasis (GO:0055075)2.75398220
115calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.75393322
116learning (GO:0007612)2.74262651
117central nervous system neuron axonogenesis (GO:0021955)2.74204849
118regulation of neurotransmitter secretion (GO:0046928)2.73468561
119regulation of beta-amyloid formation (GO:1902003)2.73223537
120negative regulation of oligodendrocyte differentiation (GO:0048715)2.72738482
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.71980206
122serotonin metabolic process (GO:0042428)2.71897248
123synapse organization (GO:0050808)2.70327844
124regulation of voltage-gated calcium channel activity (GO:1901385)2.68831730
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.68805162
126membrane hyperpolarization (GO:0060081)2.68687000
127regulation of dendritic spine morphogenesis (GO:0061001)2.68516104
128cell morphogenesis involved in neuron differentiation (GO:0048667)2.67958102
129synaptic vesicle docking involved in exocytosis (GO:0016081)2.66655081
130regulation of collateral sprouting (GO:0048670)2.63311749
131adaptation of signaling pathway (GO:0023058)2.63075092
132regulation of oligodendrocyte differentiation (GO:0048713)2.60841475
133spinal cord development (GO:0021510)2.59131429
134fucose catabolic process (GO:0019317)2.56547729
135L-fucose metabolic process (GO:0042354)2.56547729
136L-fucose catabolic process (GO:0042355)2.56547729
137detection of mechanical stimulus involved in sensory perception (GO:0050974)2.54857219
138regulation of respiratory gaseous exchange (GO:0043576)2.53591681
139membrane assembly (GO:0071709)2.53423178
140glycosphingolipid biosynthetic process (GO:0006688)2.51939969
141regulation of neurotransmitter uptake (GO:0051580)2.51848937
142Sertoli cell development (GO:0060009)2.51246914
143cochlea development (GO:0090102)2.50173071
144cellular response to cholesterol (GO:0071397)2.49806112
145regulation of action potential (GO:0098900)2.49637656
146regulation of synapse assembly (GO:0051963)2.48677890
147response to pheromone (GO:0019236)2.48385503
148positive regulation of amino acid transport (GO:0051957)2.47141144
149membrane depolarization (GO:0051899)2.45890153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.85187489
2GBX2_23144817_ChIP-Seq_PC3_Human3.70478729
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10162762
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07261088
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95586073
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58047664
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58047664
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54196859
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53532116
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51299287
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48054374
12AR_21572438_ChIP-Seq_LNCaP_Human2.47879705
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45066694
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.41192739
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.36222623
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34706581
17REST_21632747_ChIP-Seq_MESCs_Mouse2.29687662
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28142225
19DROSHA_22980978_ChIP-Seq_HELA_Human2.16651517
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.15084306
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.13071670
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08443642
23TAF15_26573619_Chip-Seq_HEK293_Human2.02408264
24* EWS_26573619_Chip-Seq_HEK293_Human1.96978060
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94516538
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92892623
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85661735
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.84201715
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82685864
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81822027
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.81724540
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.78729934
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71729758
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71172286
35* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70594977
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64053350
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60988616
38SMAD4_21799915_ChIP-Seq_A2780_Human1.60857203
39* P300_19829295_ChIP-Seq_ESCs_Human1.57795319
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56239641
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.56215496
42* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56112871
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55370649
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54925324
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49811018
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.48963358
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.45509797
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40862601
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39480141
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39478045
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.37698829
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37573368
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32804752
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29498957
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28120528
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27777564
57* STAT3_23295773_ChIP-Seq_U87_Human1.27702262
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.27632463
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.27056154
60FUS_26573619_Chip-Seq_HEK293_Human1.26874924
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26412628
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.26064631
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.25351184
64* AR_25329375_ChIP-Seq_VCAP_Human1.22134761
65ZNF274_21170338_ChIP-Seq_K562_Hela1.22070147
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21796629
67TCF4_22108803_ChIP-Seq_LS180_Human1.18607569
68CBP_20019798_ChIP-Seq_JUKART_Human1.17750270
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17750270
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17486021
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17151962
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17035115
73* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16774271
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16716121
75* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15127443
76KDM2B_26808549_Chip-Seq_REH_Human1.14101142
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12549033
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.12293988
79TCF4_23295773_ChIP-Seq_U87_Human1.12234064
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11669087
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11205974
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10319655
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.10158474
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09135126
85RXR_22108803_ChIP-Seq_LS180_Human1.08245114
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08166921
87* AR_19668381_ChIP-Seq_PC3_Human1.07927453
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07484982
89TP53_16413492_ChIP-PET_HCT116_Human1.07343614
90* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07076030
91* ER_23166858_ChIP-Seq_MCF-7_Human1.07048649
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06602665
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.06342627
94RNF2_27304074_Chip-Seq_NSC_Mouse1.05885744
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05263169
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.04324459
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04041495
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03932188
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03932188
100P53_22387025_ChIP-Seq_ESCs_Mouse1.02915775
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02792998
102BCAT_22108803_ChIP-Seq_LS180_Human1.02108363
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.01762496
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00571935
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.00133978
106* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99754048
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99087254
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.98215372
109TP53_18474530_ChIP-ChIP_U2OS_Human0.97533557
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96734160
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.96635635
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96581416
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93457568
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93402298
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.92290008
116JUN_21703547_ChIP-Seq_K562_Human0.91926892
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.90863093
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90040036
119AHR_22903824_ChIP-Seq_MCF-7_Human0.89663334
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88496932
121VDR_22108803_ChIP-Seq_LS180_Human0.87264622
122IGF1R_20145208_ChIP-Seq_DFB_Human0.87233052
123SOX9_26525672_Chip-Seq_HEART_Mouse0.86153601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.77572806
2MP0003880_abnormal_central_pattern4.16506206
3MP0003136_yellow_coat_color4.15139761
4MP0003635_abnormal_synaptic_transmissio3.41563638
5MP0004270_analgesia3.37137802
6MP0005171_absent_coat_pigmentation3.23797274
7MP0009046_muscle_twitch3.15921058
8MP0009745_abnormal_behavioral_response2.98939666
9MP0002064_seizures2.93672613
10MP0001486_abnormal_startle_reflex2.86773518
11MP0005423_abnormal_somatic_nervous2.79953278
12MP0001968_abnormal_touch/_nociception2.71621999
13MP0002063_abnormal_learning/memory/cond2.65921353
14MP0002272_abnormal_nervous_system2.55681465
15MP0002572_abnormal_emotion/affect_behav2.50730352
16MP0003690_abnormal_glial_cell2.45826004
17MP0004858_abnormal_nervous_system2.43388287
18MP0004885_abnormal_endolymph2.42564608
19MP0002736_abnormal_nociception_after2.41573711
20MP0003329_amyloid_beta_deposits2.35882744
21MP0002734_abnormal_mechanical_nocicepti2.34810468
22MP0001440_abnormal_grooming_behavior2.30750766
23MP0003787_abnormal_imprinting2.21535788
24MP0008877_abnormal_DNA_methylation2.16632424
25MP0000920_abnormal_myelination2.05027985
26MP0002067_abnormal_sensory_capabilities2.01453226
27MP0001501_abnormal_sleep_pattern1.92994723
28MP0000778_abnormal_nervous_system1.91921934
29MP0008569_lethality_at_weaning1.91880665
30MP0000569_abnormal_digit_pigmentation1.90364002
31MP0002735_abnormal_chemical_nociception1.90148524
32MP0002733_abnormal_thermal_nociception1.88563437
33MP0004742_abnormal_vestibular_system1.85736413
34MP0001970_abnormal_pain_threshold1.80090334
35MP0004142_abnormal_muscle_tone1.65925795
36MP0001485_abnormal_pinna_reflex1.63678039
37MP0004924_abnormal_behavior1.62009120
38MP0005386_behavior/neurological_phenoty1.62009120
39MP0002557_abnormal_social/conspecific_i1.60516616
40MP0003634_abnormal_glial_cell1.60009701
41MP0001905_abnormal_dopamine_level1.58900913
42MP0001529_abnormal_vocalization1.54769763
43MP0005646_abnormal_pituitary_gland1.54408703
44MP0001984_abnormal_olfaction1.54029834
45MP0002822_catalepsy1.53045253
46MP0002184_abnormal_innervation1.51949987
47MP0003632_abnormal_nervous_system1.47175017
48MP0001502_abnormal_circadian_rhythm1.44352770
49MP0009780_abnormal_chondrocyte_physiolo1.42937955
50MP0002882_abnormal_neuron_morphology1.42789134
51MP0003121_genomic_imprinting1.40929516
52MP0003011_delayed_dark_adaptation1.40686928
53MP0000955_abnormal_spinal_cord1.39845083
54MP0005409_darkened_coat_color1.39694414
55MP0005187_abnormal_penis_morphology1.38848527
56MP0002066_abnormal_motor_capabilities/c1.37707411
57MP0003631_nervous_system_phenotype1.37367176
58MP0003633_abnormal_nervous_system1.37236896
59MP0003122_maternal_imprinting1.35129141
60MP0002229_neurodegeneration1.26515008
61MP0002751_abnormal_autonomic_nervous1.24705059
62MP0001963_abnormal_hearing_physiology1.23584133
63MP0005645_abnormal_hypothalamus_physiol1.22935114
64MP0005551_abnormal_eye_electrophysiolog1.22394476
65MP0004133_heterotaxia1.22095007
66MP0006292_abnormal_olfactory_placode1.21029897
67MP0004147_increased_porphyrin_level1.20686760
68MP0002653_abnormal_ependyma_morphology1.20485102
69MP0006276_abnormal_autonomic_nervous1.15918453
70MP0004811_abnormal_neuron_physiology1.15252302
71MP0000604_amyloidosis1.13049125
72MP0002234_abnormal_pharynx_morphology1.10369904
73MP0002152_abnormal_brain_morphology1.08210156
74MP0001986_abnormal_taste_sensitivity1.03076879
75MP0002102_abnormal_ear_morphology1.02430232
76MP0003868_abnormal_feces_composition0.96433651
77MP0009384_cardiac_valve_regurgitation0.93360710
78MP0002752_abnormal_somatic_nervous0.92313105
79MP0000427_abnormal_hair_cycle0.89989523
80MP0000647_abnormal_sebaceous_gland0.89607908
81MP0000049_abnormal_middle_ear0.89583738
82MP0000026_abnormal_inner_ear0.88627892
83MP0003137_abnormal_impulse_conducting0.86954299
84MP0000566_synostosis0.85615917
85MP0003195_calcinosis0.85614363
86MP0001188_hyperpigmentation0.85254588
87MP0001177_atelectasis0.83572075
88MP0001664_abnormal_digestion0.82052337
89MP0005167_abnormal_blood-brain_barrier0.81284610
90MP0004215_abnormal_myocardial_fiber0.80931781
91MP0003075_altered_response_to0.79521945
92MP0003119_abnormal_digestive_system0.78172878
93MP0004145_abnormal_muscle_electrophysio0.77615492
94MP0002638_abnormal_pupillary_reflex0.77578160
95MP0002090_abnormal_vision0.77420666
96MP0003937_abnormal_limbs/digits/tail_de0.75392798
97MP0004043_abnormal_pH_regulation0.74169329
98MP0005410_abnormal_fertilization0.73045709
99MP0002069_abnormal_eating/drinking_beha0.72948112
100MP0000631_abnormal_neuroendocrine_gland0.72934326
101MP0002928_abnormal_bile_duct0.72123471
102MP0001299_abnormal_eye_distance/0.70314848
103MP0002909_abnormal_adrenal_gland0.70284918
104MP0000538_abnormal_urinary_bladder0.70049409
105MP0008789_abnormal_olfactory_epithelium0.69053027
106MP0003878_abnormal_ear_physiology0.68976296
107MP0005377_hearing/vestibular/ear_phenot0.68976296
108MP0001919_abnormal_reproductive_system0.68299805
109MP0004085_abnormal_heartbeat0.67751521
110MP0005391_vision/eye_phenotype0.67135977
111MP0005253_abnormal_eye_physiology0.66621965
112MP0003172_abnormal_lysosome_physiology0.66380812
113MP0002095_abnormal_skin_pigmentation0.64526090
114MP0003879_abnormal_hair_cell0.64437635
115MP0008872_abnormal_physiological_respon0.60659146
116MP0000462_abnormal_digestive_system0.60445938
117MP0003183_abnormal_peptide_metabolism0.60322794
118MP0008874_decreased_physiological_sensi0.59992234
119MP0001943_abnormal_respiration0.57112726
120MP0005535_abnormal_body_temperature0.55457874
121MP0002254_reproductive_system_inflammat0.55151025
122MP0005595_abnormal_vascular_smooth0.55006720
123MP0006072_abnormal_retinal_apoptosis0.52828910
124MP0002089_abnormal_postnatal_growth/wei0.51341908
125MP0004134_abnormal_chest_morphology0.51297327
126MP0000751_myopathy0.50116471
127MP0003861_abnormal_nervous_system0.48955443
128MP0005195_abnormal_posterior_eye0.48478900
129MP0003938_abnormal_ear_development0.48457941

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.26855776
2Myokymia (HP:0002411)5.01451742
3Neurofibrillary tangles (HP:0002185)4.54126154
4Focal seizures (HP:0007359)4.50597054
5Epileptic encephalopathy (HP:0200134)4.41214471
6Atonic seizures (HP:0010819)4.38694605
7Aplasia involving bones of the extremities (HP:0009825)4.22480715
8Aplasia involving bones of the upper limbs (HP:0009823)4.22480715
9Aplasia of the phalanges of the hand (HP:0009802)4.22480715
10Progressive cerebellar ataxia (HP:0002073)3.79518021
11Megalencephaly (HP:0001355)3.75782973
12Action tremor (HP:0002345)3.72713333
13Cerebral inclusion bodies (HP:0100314)3.60067250
14True hermaphroditism (HP:0010459)3.53527103
15Supranuclear gaze palsy (HP:0000605)3.52963016
16Hemiparesis (HP:0001269)3.48254165
17Blue irides (HP:0000635)3.39980496
18Febrile seizures (HP:0002373)3.39540239
19Visual hallucinations (HP:0002367)3.28086204
20Hyperventilation (HP:0002883)3.22769345
21Absence seizures (HP:0002121)3.19305016
22Type II lissencephaly (HP:0007260)3.18352831
23Abnormality of binocular vision (HP:0011514)3.13360294
24Diplopia (HP:0000651)3.13360294
25Generalized tonic-clonic seizures (HP:0002069)3.12859918
26Abnormal auditory evoked potentials (HP:0006958)3.12240491
27Congenital sensorineural hearing impairment (HP:0008527)3.12007596
28Dialeptic seizures (HP:0011146)3.07449587
29Dysmetria (HP:0001310)3.06774486
30Pancreatic cysts (HP:0001737)3.06481598
31Protruding tongue (HP:0010808)3.06006660
32Pancreatic fibrosis (HP:0100732)3.05591359
33Limb dystonia (HP:0002451)3.03330227
34Intention tremor (HP:0002080)3.01306543
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.98333524
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.98333524
37Dysdiadochokinesis (HP:0002075)2.98041707
38Abnormality of the corticospinal tract (HP:0002492)2.93870590
39Truncal ataxia (HP:0002078)2.93551708
40Medial flaring of the eyebrow (HP:0010747)2.88193368
41Hemiplegia (HP:0002301)2.87548485
42Broad-based gait (HP:0002136)2.86956315
43Abnormality of midbrain morphology (HP:0002418)2.86777368
44Molar tooth sign on MRI (HP:0002419)2.86777368
45White forelock (HP:0002211)2.86081813
46Spastic gait (HP:0002064)2.82868709
47Gaze-evoked nystagmus (HP:0000640)2.82673655
48Peripheral hypomyelination (HP:0007182)2.72902662
49Stomach cancer (HP:0012126)2.71362081
50Lissencephaly (HP:0001339)2.70662516
51Spastic paraparesis (HP:0002313)2.69259246
52Scanning speech (HP:0002168)2.68614048
53Oligodactyly (hands) (HP:0001180)2.67753062
54Abnormal eating behavior (HP:0100738)2.67520311
55Nephronophthisis (HP:0000090)2.64707750
56Patchy hypopigmentation of hair (HP:0011365)2.62006605
57Hypoplastic left heart (HP:0004383)2.60021379
58Pheochromocytoma (HP:0002666)2.56773072
59Colon cancer (HP:0003003)2.53513819
60Clumsiness (HP:0002312)2.52249650
61Congenital primary aphakia (HP:0007707)2.52029560
62Large for gestational age (HP:0001520)2.48805240
63Neuroendocrine neoplasm (HP:0100634)2.48629582
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.47795952
65Ankle clonus (HP:0011448)2.47707374
66Genetic anticipation (HP:0003743)2.47377918
67Optic nerve hypoplasia (HP:0000609)2.45739216
68Nephrogenic diabetes insipidus (HP:0009806)2.41005794
69Paraparesis (HP:0002385)2.40160906
70Pachygyria (HP:0001302)2.39288422
71Inability to walk (HP:0002540)2.36650938
72Congenital stationary night blindness (HP:0007642)2.35159769
73Postural instability (HP:0002172)2.33673214
74Status epilepticus (HP:0002133)2.33028103
75Impaired vibration sensation in the lower limbs (HP:0002166)2.31537578
76Pendular nystagmus (HP:0012043)2.30483606
77Termporal pattern (HP:0011008)2.28537186
78Insidious onset (HP:0003587)2.28537186
79Abnormality of the labia minora (HP:0012880)2.28505133
80Anxiety (HP:0000739)2.26458566
81Lower limb muscle weakness (HP:0007340)2.24551619
82Abnormality of the renal medulla (HP:0100957)2.23813610
83Mixed hearing impairment (HP:0000410)2.22558116
84Sensory axonal neuropathy (HP:0003390)2.21416380
85Retinal dysplasia (HP:0007973)2.20828140
86Polyphagia (HP:0002591)2.19108084
87Akinesia (HP:0002304)2.18816361
88Fetal akinesia sequence (HP:0001989)2.18250016
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15640617
90Generalized myoclonic seizures (HP:0002123)2.15530038
91Urinary bladder sphincter dysfunction (HP:0002839)2.12578484
92Synostosis involving the elbow (HP:0003938)2.11933307
93Humeroradial synostosis (HP:0003041)2.11933307
94Glioma (HP:0009733)2.09386249
95Depression (HP:0000716)2.08484305
96Renal cortical cysts (HP:0000803)2.07313643
97Cystic liver disease (HP:0006706)2.07150135
98Progressive inability to walk (HP:0002505)2.06912102
99Split foot (HP:0001839)2.06903934
100Neoplasm of the oral cavity (HP:0100649)2.05128457
101Abnormality of the renal cortex (HP:0011035)2.04339124
102Patellar aplasia (HP:0006443)2.03983685
103Specific learning disability (HP:0001328)2.03489869
104Absent speech (HP:0001344)2.01715206
105Abolished electroretinogram (ERG) (HP:0000550)2.00599847
106Thickened helices (HP:0000391)1.99358838
107Hypoplastic heart (HP:0001961)1.99058853
108Heterochromia iridis (HP:0001100)1.97916064
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.97009345
110Increased circulating renin level (HP:0000848)1.96847796
111Gait imbalance (HP:0002141)1.94030212
112Tented upper lip vermilion (HP:0010804)1.93914073
113Alacrima (HP:0000522)1.92862544
114Aplasia/Hypoplasia of the patella (HP:0006498)1.92862408
115Drooling (HP:0002307)1.92163495
116Excessive salivation (HP:0003781)1.92163495
117Narrow nasal bridge (HP:0000446)1.91885751
118Postaxial hand polydactyly (HP:0001162)1.91111885
119Attenuation of retinal blood vessels (HP:0007843)1.90421234
120Bony spicule pigmentary retinopathy (HP:0007737)1.89033961
121Hepatoblastoma (HP:0002884)1.86956206
122Abnormality of the astrocytes (HP:0100707)1.86262147
123Astrocytoma (HP:0009592)1.86262147
124Chronic hepatic failure (HP:0100626)1.86037601
125Epileptiform EEG discharges (HP:0011182)1.85162878
126Sclerocornea (HP:0000647)1.84165643
127Epidermoid cyst (HP:0200040)1.84056175
128EEG with generalized epileptiform discharges (HP:0011198)1.83165740
129Abnormality of secondary sexual hair (HP:0009888)1.81162965
130Abnormality of the axillary hair (HP:0100134)1.81162965
131Stereotypic behavior (HP:0000733)1.80228773
132Adactyly (HP:0009776)1.80177118
133Vaginal atresia (HP:0000148)1.80077649
134Morphological abnormality of the pyramidal tract (HP:0002062)1.79771700
135Poor coordination (HP:0002370)1.79190682
136Urinary urgency (HP:0000012)1.78590405
137Hypsarrhythmia (HP:0002521)1.78542203
138Septo-optic dysplasia (HP:0100842)1.78474363
139Poor eye contact (HP:0000817)1.78436442
140Oligodactyly (HP:0012165)1.78427638
141Genital tract atresia (HP:0001827)1.77494716
142Abnormal social behavior (HP:0012433)1.76213642
143Impaired social interactions (HP:0000735)1.76213642
144Parakeratosis (HP:0001036)1.76177968
145Aplasia/Hypoplasia of the fibula (HP:0006492)1.75736328
146Long nose (HP:0003189)1.75546302
147Polydipsia (HP:0001959)1.75173372
148Abnormal drinking behavior (HP:0030082)1.75173372
149Neoplasm of the peripheral nervous system (HP:0100007)1.74151168
150Short tibia (HP:0005736)1.73451446
151Postural tremor (HP:0002174)1.72929767
152Hypoplastic pelvis (HP:0008839)1.72489187
153Gastrointestinal atresia (HP:0002589)1.72069894
154Short foot (HP:0001773)1.70871563
155Intestinal atresia (HP:0011100)1.70357785
156Relative macrocephaly (HP:0004482)1.69276089
157Gait ataxia (HP:0002066)1.69058612
158Intellectual disability, severe (HP:0010864)1.68661909
159Widely spaced teeth (HP:0000687)1.68169742
160Abnormality of macular pigmentation (HP:0008002)1.67902361
161Leukodystrophy (HP:0002415)1.67275347
162Chorioretinal atrophy (HP:0000533)1.66056681
163Male pseudohermaphroditism (HP:0000037)1.65685049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.07402336
2FRK3.98544774
3EPHA43.61947385
4CASK3.17731313
5NTRK33.13046737
6PRKD32.77625062
7WNK32.76004465
8NTRK22.75397630
9STK392.50035856
10MARK12.46298983
11MAP3K42.43320531
12MAP2K72.27500986
13MAP3K92.17482006
14OXSR12.03921831
15MINK12.00050093
16MAPK131.93324736
17NTRK11.93128132
18BMPR1B1.84231259
19PAK61.80008968
20PHKG21.78202751
21PHKG11.78202751
22MUSK1.70836707
23MAP4K21.68489608
24DYRK21.64463627
25TYRO31.53661963
26GRK11.50557987
27LMTK21.48359752
28PRPF4B1.46580871
29FES1.44398582
30ADRBK21.44204960
31NUAK11.43765865
32MAP2K41.41476936
33INSRR1.39511055
34TAOK31.38746255
35CDK51.38562176
36MAPK151.38339960
37SGK4941.38181576
38SGK2231.38181576
39CCNB11.37255741
40CDK191.31728865
41UHMK11.30978609
42NEK61.28276203
43CSNK1G11.28160078
44DAPK21.22878312
45PNCK1.20973512
46PRKCG1.19755159
47ARAF1.19068598
48RIPK41.17804445
49WNK11.15566471
50MKNK21.13838670
51KSR21.11773448
52ACVR1B1.11129257
53PLK21.08632036
54SGK21.07252059
55GRK51.04832003
56FGR1.02370935
57PKN11.01034680
58WEE10.98616882
59TSSK60.98582105
60CAMKK10.97706980
61CAMK2A0.97323709
62BCR0.96167397
63WNK40.91834148
64PINK10.91724994
65KSR10.89600052
66PRKCE0.88529981
67FGFR20.86650338
68ROCK20.86449031
69PAK30.84298169
70PRKCH0.84139213
71CAMK2B0.82675268
72CSNK1G20.82635633
73MAP3K120.82403405
74EPHB10.81934505
75CDK140.81915387
76SGK30.80509049
77CDK150.78570038
78CDK180.77645920
79CAMKK20.75672969
80TNK20.75581821
81ICK0.75484635
82AKT30.73390474
83CAMK1D0.71526474
84RET0.69041020
85CAMK2D0.68166630
86SGK10.67606816
87CDK11A0.67098992
88ERBB30.66900789
89MAPKAPK50.66393042
90CAMK2G0.65223152
91MAP3K130.63010805
92STK110.62688132
93EPHA30.61841601
94DYRK1A0.61603325
95MAP3K20.61153333
96PRKCQ0.60810469
97PDPK10.57769395
98MAPK120.57359489
99ZAK0.57242003
100CSNK1A10.55904346
101BMPR20.55496590
102IRAK20.55421908
103FYN0.54610324
104DYRK30.53171310
105SIK20.53170032
106STK380.53000726
107ALK0.52678284
108YES10.51567004
109MAPK70.50100341
110PIK3CA0.48664616
111MARK20.48519509
112CDK30.48226095
113PDK10.47031536
114CAMK10.46997045
115ERBB40.46570084
116ADRBK10.45918678
117STK38L0.45485607
118TAF10.44480954
119CSNK1G30.43636878
120RPS6KA30.43011327
121CSNK1D0.42802555
122PRKACA0.41985936
123PTK2B0.41578648
124CSNK1A1L0.41465562
125PRKD20.40878712
126PRKCZ0.40501963
127CAMK1G0.40349275
128MAP3K60.40246413
129ROCK10.40238501
130RAF10.38670073
131ERBB20.37876977
132PRKG10.37815339
133TAOK10.34629413
134CAMK40.31187713
135MAP2K10.29495331
136MKNK10.29007957
137TRIM280.28247321
138FER0.27560977
139TGFBR10.26566671
140VRK10.26219749

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65222100
2GABAergic synapse_Homo sapiens_hsa047272.81153844
3Glutamatergic synapse_Homo sapiens_hsa047242.73448779
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65624403
5Synaptic vesicle cycle_Homo sapiens_hsa047212.38259544
6Morphine addiction_Homo sapiens_hsa050322.34097955
7Circadian entrainment_Homo sapiens_hsa047132.29506648
8Nitrogen metabolism_Homo sapiens_hsa009102.20563224
9Long-term potentiation_Homo sapiens_hsa047202.15611499
10Salivary secretion_Homo sapiens_hsa049702.07528372
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95195496
12Olfactory transduction_Homo sapiens_hsa047401.91355502
13Steroid biosynthesis_Homo sapiens_hsa001001.85681005
14Long-term depression_Homo sapiens_hsa047301.82316763
15Gastric acid secretion_Homo sapiens_hsa049711.79374454
16Dopaminergic synapse_Homo sapiens_hsa047281.73648491
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71581093
18Amphetamine addiction_Homo sapiens_hsa050311.71090234
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70114967
20Serotonergic synapse_Homo sapiens_hsa047261.70086959
21Insulin secretion_Homo sapiens_hsa049111.62678215
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62346723
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61601540
24Cholinergic synapse_Homo sapiens_hsa047251.60057253
25Taste transduction_Homo sapiens_hsa047421.58980714
26Fatty acid biosynthesis_Homo sapiens_hsa000611.54712363
27Linoleic acid metabolism_Homo sapiens_hsa005911.47923953
28Calcium signaling pathway_Homo sapiens_hsa040201.47389095
29Axon guidance_Homo sapiens_hsa043601.39376461
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30039676
31Renin secretion_Homo sapiens_hsa049241.28494790
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27316167
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26484752
34Propanoate metabolism_Homo sapiens_hsa006401.26142431
35Collecting duct acid secretion_Homo sapiens_hsa049661.24420839
36Cocaine addiction_Homo sapiens_hsa050301.23006204
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22296996
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21934929
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21335768
40Oxytocin signaling pathway_Homo sapiens_hsa049211.16732404
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16288386
42Gap junction_Homo sapiens_hsa045401.15941561
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15236065
44Ether lipid metabolism_Homo sapiens_hsa005651.13561854
45Fatty acid elongation_Homo sapiens_hsa000621.13252224
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13190935
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11870296
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10696804
49Basal transcription factors_Homo sapiens_hsa030221.09793354
50Cardiac muscle contraction_Homo sapiens_hsa042601.08236015
51cAMP signaling pathway_Homo sapiens_hsa040241.06169945
52GnRH signaling pathway_Homo sapiens_hsa049121.05776890
53Dorso-ventral axis formation_Homo sapiens_hsa043201.03986724
54Histidine metabolism_Homo sapiens_hsa003401.01964153
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.00166935
56Tryptophan metabolism_Homo sapiens_hsa003800.99539228
57Pancreatic secretion_Homo sapiens_hsa049720.98179032
58Melanogenesis_Homo sapiens_hsa049160.97801325
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92128281
60ABC transporters_Homo sapiens_hsa020100.91195676
61Protein export_Homo sapiens_hsa030600.89782934
62ErbB signaling pathway_Homo sapiens_hsa040120.89434619
63Butanoate metabolism_Homo sapiens_hsa006500.87062560
64beta-Alanine metabolism_Homo sapiens_hsa004100.85775417
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85564572
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.83653300
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82516843
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81852798
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.80597556
70Oxidative phosphorylation_Homo sapiens_hsa001900.78800185
71Choline metabolism in cancer_Homo sapiens_hsa052310.77323005
72Estrogen signaling pathway_Homo sapiens_hsa049150.77288935
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76780283
74Fanconi anemia pathway_Homo sapiens_hsa034600.75512195
75Alzheimers disease_Homo sapiens_hsa050100.74583510
76Selenocompound metabolism_Homo sapiens_hsa004500.73781487
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73104306
78Glioma_Homo sapiens_hsa052140.72992233
79Thyroid hormone synthesis_Homo sapiens_hsa049180.71514968
80Fatty acid metabolism_Homo sapiens_hsa012120.71033023
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.68047013
82Bile secretion_Homo sapiens_hsa049760.67075248
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67057763
84Vibrio cholerae infection_Homo sapiens_hsa051100.66550899
85Peroxisome_Homo sapiens_hsa041460.65169879
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64657237
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.63669172
88Type II diabetes mellitus_Homo sapiens_hsa049300.61394016
89Caffeine metabolism_Homo sapiens_hsa002320.59724651
90Mineral absorption_Homo sapiens_hsa049780.58831464
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57986119
92Ras signaling pathway_Homo sapiens_hsa040140.57983759
93Basal cell carcinoma_Homo sapiens_hsa052170.57284417
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57238091
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.56906423
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56682128
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55581028
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54240205
99Sphingolipid metabolism_Homo sapiens_hsa006000.53342199
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53260018
101Glycerolipid metabolism_Homo sapiens_hsa005610.53159505
102Renal cell carcinoma_Homo sapiens_hsa052110.53024077
103Phototransduction_Homo sapiens_hsa047440.52008628
104Hippo signaling pathway_Homo sapiens_hsa043900.51879801
105Circadian rhythm_Homo sapiens_hsa047100.51829018
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51627847
107MAPK signaling pathway_Homo sapiens_hsa040100.51383422
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49492932
109Sulfur metabolism_Homo sapiens_hsa009200.48853431
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47740550
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.46919469
112Dilated cardiomyopathy_Homo sapiens_hsa054140.46411976
113Hedgehog signaling pathway_Homo sapiens_hsa043400.46138593
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45208411
115Homologous recombination_Homo sapiens_hsa034400.45130893
116Parkinsons disease_Homo sapiens_hsa050120.43467445
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43423861
118African trypanosomiasis_Homo sapiens_hsa051430.43083157
119Rap1 signaling pathway_Homo sapiens_hsa040150.42311803
120Regulation of autophagy_Homo sapiens_hsa041400.40542539
121Chemical carcinogenesis_Homo sapiens_hsa052040.39455291
122Retinol metabolism_Homo sapiens_hsa008300.38725545
123Endocytosis_Homo sapiens_hsa041440.37455820
124Inositol phosphate metabolism_Homo sapiens_hsa005620.37188754
125Ovarian steroidogenesis_Homo sapiens_hsa049130.36597972
126Wnt signaling pathway_Homo sapiens_hsa043100.36020939
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34837018
128Oocyte meiosis_Homo sapiens_hsa041140.34303135
129Alcoholism_Homo sapiens_hsa050340.32404085
130Rheumatoid arthritis_Homo sapiens_hsa053230.31598635
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30943589

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