LUZP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A bi-cistronic transcript encodes the products of both the myotrophin and leucine zipper protein 6 genes, which are located on chromosome 7. A cryptic ORF at the 3' end of the myotrophin transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.34507892
2cellular response to nitric oxide (GO:0071732)6.21800671
3regulation of Golgi to plasma membrane protein transport (GO:0042996)5.84441220
4forebrain morphogenesis (GO:0048853)5.80853921
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.74536775
6regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.58808010
7ncRNA 3-end processing (GO:0043628)4.56059455
8phagocytosis, engulfment (GO:0006911)4.51135556
9response to nitric oxide (GO:0071731)4.34299758
10iron-sulfur cluster assembly (GO:0016226)4.30987162
11metallo-sulfur cluster assembly (GO:0031163)4.30987162
12formation of translation preinitiation complex (GO:0001731)4.22879608
13response to pheromone (GO:0019236)4.22182933
14autophagic vacuole fusion (GO:0000046)4.20619103
15piRNA metabolic process (GO:0034587)4.18160548
16pyrimidine nucleotide catabolic process (GO:0006244)4.13992274
17regulation of meiosis I (GO:0060631)4.06594098
18definitive hemopoiesis (GO:0060216)4.04829366
19cellular response to reactive nitrogen species (GO:1902170)4.03503130
20negative regulation of telomere maintenance (GO:0032205)4.03181796
21positive regulation of interleukin-17 production (GO:0032740)4.01650558
22seminiferous tubule development (GO:0072520)3.86319403
23positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.84057766
24skeletal muscle tissue regeneration (GO:0043403)3.76731341
25ribosomal large subunit biogenesis (GO:0042273)3.67642173
26RNA destabilization (GO:0050779)3.65150624
27mRNA modification (GO:0016556)3.63462895
28ether lipid metabolic process (GO:0046485)3.53096120
29organ formation (GO:0048645)3.52027264
30translational termination (GO:0006415)3.47852718
31regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.46912394
32lens morphogenesis in camera-type eye (GO:0002089)3.46121778
33viral transcription (GO:0019083)3.44918955
34neutrophil activation involved in immune response (GO:0002283)3.39592981
35translational elongation (GO:0006414)3.35717429
36maturation of 5.8S rRNA (GO:0000460)3.34517284
37S-adenosylmethionine metabolic process (GO:0046500)3.34276645
38nerve growth factor signaling pathway (GO:0038180)3.33950903
39positive regulation of granulocyte differentiation (GO:0030854)3.31758318
40organelle membrane fusion (GO:0090174)3.30243970
41negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.28663548
42indolalkylamine metabolic process (GO:0006586)3.23595857
43glyoxylate metabolic process (GO:0046487)3.12576716
44positive regulation of growth hormone secretion (GO:0060124)3.10901900
45thyroid gland development (GO:0030878)3.08070310
46pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05962468
47translational initiation (GO:0006413)3.02849649
48mannosylation (GO:0097502)3.02313046
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01832462
50vesicle fusion (GO:0006906)2.97382959
51positive regulation of T cell cytokine production (GO:0002726)2.96765653
52epithelial cell differentiation involved in kidney development (GO:0035850)2.95465191
53lipopolysaccharide biosynthetic process (GO:0009103)2.93286741
54positive regulation of vasculogenesis (GO:2001214)2.87425408
55ubiquinone biosynthetic process (GO:0006744)2.87342827
56cytokine biosynthetic process (GO:0042089)2.86933455
57negative regulation of granulocyte differentiation (GO:0030853)2.85578630
58membrane invagination (GO:0010324)2.85180979
59sleep (GO:0030431)2.83936304
60GMP metabolic process (GO:0046037)2.83585632
61positive regulation of protein homodimerization activity (GO:0090073)2.82897610
62oxidative demethylation (GO:0070989)2.81972908
63deoxyribose phosphate catabolic process (GO:0046386)2.81751485
64negative regulation of mast cell activation (GO:0033004)2.81002760
65DNA demethylation (GO:0080111)2.78552794
66base-excision repair, AP site formation (GO:0006285)2.78457495
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76569839
68axoneme assembly (GO:0035082)2.73093374
69deoxyribonucleotide catabolic process (GO:0009264)2.72193850
70cotranslational protein targeting to membrane (GO:0006613)2.68021857
71megakaryocyte development (GO:0035855)2.65617651
72ubiquinone metabolic process (GO:0006743)2.64710643
73negative regulation of protein tyrosine kinase activity (GO:0061099)2.63031386
74protein localization to endoplasmic reticulum (GO:0070972)2.62525843
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61893204
76ribonucleoprotein complex disassembly (GO:0032988)2.61751893
77T-helper 1 type immune response (GO:0042088)2.58750966
78protein targeting to ER (GO:0045047)2.58622610
79poly(A)+ mRNA export from nucleus (GO:0016973)2.57008422
80cellular protein complex disassembly (GO:0043624)2.54976640
81otic vesicle formation (GO:0030916)2.54218095
82quinone biosynthetic process (GO:1901663)2.53200852
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53178300
84negative regulation of meiotic cell cycle (GO:0051447)2.52768595
85male meiosis I (GO:0007141)2.51362812
86positive regulation of B cell differentiation (GO:0045579)2.50092660
87cornea development in camera-type eye (GO:0061303)2.49928888
88establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48168429
89regulation of female gonad development (GO:2000194)2.46874424
90phosphatidylethanolamine metabolic process (GO:0046337)2.44808007
91lipopolysaccharide metabolic process (GO:0008653)2.44353672
92viral life cycle (GO:0019058)2.44324504
93regulation of protein homodimerization activity (GO:0043496)2.42075873
94phosphatidylethanolamine biosynthetic process (GO:0006646)2.41708209
95positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40953928
96cranial nerve morphogenesis (GO:0021602)2.39841022
97positive regulation of gluconeogenesis (GO:0045722)2.38760795
98regulation of cilium movement (GO:0003352)2.37877098
99transcription elongation from RNA polymerase III promoter (GO:0006385)2.36925499
100termination of RNA polymerase III transcription (GO:0006386)2.36925499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse8.43737477
2VDR_22108803_ChIP-Seq_LS180_Human3.21619575
3IGF1R_20145208_ChIP-Seq_DFB_Human3.17606150
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.12509803
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.98062849
6GATA1_26923725_Chip-Seq_HPCs_Mouse2.91138828
7* FUS_26573619_Chip-Seq_HEK293_Human2.46315038
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42983474
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35386506
10ZNF274_21170338_ChIP-Seq_K562_Hela2.34582747
11EWS_26573619_Chip-Seq_HEK293_Human2.33397662
12GBX2_23144817_ChIP-Seq_PC3_Human2.22034588
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18494369
14ELK1_19687146_ChIP-ChIP_HELA_Human2.18443616
15SCL_19346495_ChIP-Seq_HPC-7_Human2.18282708
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.03688634
17MYC_18940864_ChIP-ChIP_HL60_Human1.95060042
18VDR_23849224_ChIP-Seq_CD4+_Human1.93065896
19ER_23166858_ChIP-Seq_MCF-7_Human1.89127836
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81186357
21TAF15_26573619_Chip-Seq_HEK293_Human1.79524342
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75993417
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74680922
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70267542
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61361011
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59928982
27CBP_20019798_ChIP-Seq_JUKART_Human1.57841628
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57841628
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57305802
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.55577955
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53321594
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52964160
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52879560
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48305944
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44715319
36* P300_19829295_ChIP-Seq_ESCs_Human1.42200661
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39807785
38ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38365072
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.36648673
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36648673
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36385218
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.35145192
43GATA1_22025678_ChIP-Seq_K562_Human1.35039437
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33225330
45TP53_22573176_ChIP-Seq_HFKS_Human1.31554834
46RNF2_27304074_Chip-Seq_NSC_Mouse1.28895698
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28529665
48FOXP3_21729870_ChIP-Seq_TREG_Human1.26896414
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26432151
50MYB_26560356_Chip-Seq_TH2_Human1.24833033
51AR_20517297_ChIP-Seq_VCAP_Human1.23409902
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21182665
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20670987
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.20243645
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20184368
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19833562
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19819548
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18812503
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17560026
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17551940
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12543574
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09910955
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09234371
64ERG_20517297_ChIP-Seq_VCAP_Human1.09185432
65WDR5_24793694_ChIP-Seq_LNCAP_Human1.07821621
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06712873
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05722400
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.03183650
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.00479339
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99239364
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98834897
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98056355
73PRDM14_20953172_ChIP-Seq_ESCs_Human0.98052880
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97813558
75EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97323557
76SRF_21415370_ChIP-Seq_HL-1_Mouse0.96267077
77NANOG_20526341_ChIP-Seq_ESCs_Human0.95782365
78GATA3_26560356_Chip-Seq_TH1_Human0.95277171
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94372786
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.94173039
81IRF1_19129219_ChIP-ChIP_H3396_Human0.92901098
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92765769
83SOX2_19829295_ChIP-Seq_ESCs_Human0.92728489
84NANOG_19829295_ChIP-Seq_ESCs_Human0.92728489
85NCOR_22424771_ChIP-Seq_293T_Human0.92402556
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92338990
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92164303
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91282108
89HTT_18923047_ChIP-ChIP_STHdh_Human0.91116017
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.90861099
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90800635
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90356374
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.89490630
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87740403
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87650402
96SPI1_23547873_ChIP-Seq_NB4_Human0.87139896
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86126528
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85471654
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83835355
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.83126336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.57902413
2MP0006292_abnormal_olfactory_placode3.37171402
3MP0005084_abnormal_gallbladder_morpholo3.08380281
4MP0009697_abnormal_copulation2.92099458
5MP0009379_abnormal_foot_pigmentation2.86702291
6MP0002822_catalepsy2.84384288
7MP0002138_abnormal_hepatobiliary_system2.82952490
8MP0008057_abnormal_DNA_replication2.73122503
9MP0000465_gastrointestinal_hemorrhage2.61857296
10MP0001188_hyperpigmentation2.55936333
11MP0001986_abnormal_taste_sensitivity2.39632802
12MP0002102_abnormal_ear_morphology2.31230396
13MP0002876_abnormal_thyroid_physiology2.27712778
14MP0002132_abnormal_respiratory_system2.21457275
15MP0001873_stomach_inflammation2.19665229
16MP0008877_abnormal_DNA_methylation2.16624334
17MP0003763_abnormal_thymus_physiology2.10004837
18MP0001764_abnormal_homeostasis2.08513215
19MP0000681_abnormal_thyroid_gland2.03168821
20MP0008058_abnormal_DNA_repair2.01784322
21MP0002396_abnormal_hematopoietic_system1.99825825
22MP0002928_abnormal_bile_duct1.92301247
23MP0003787_abnormal_imprinting1.83786881
24MP0001529_abnormal_vocalization1.83693645
25MP0004808_abnormal_hematopoietic_stem1.82077353
26MP0002653_abnormal_ependyma_morphology1.79483266
27MP0005075_abnormal_melanosome_morpholog1.74048339
28MP0005646_abnormal_pituitary_gland1.62074237
29MP0008789_abnormal_olfactory_epithelium1.60403998
30MP0002095_abnormal_skin_pigmentation1.49558212
31MP0006276_abnormal_autonomic_nervous1.46201944
32MP0003567_abnormal_fetal_cardiomyocyte1.42707488
33MP0002127_abnormal_cardiovascular_syste1.37855126
34MP0003121_genomic_imprinting1.37119737
35MP0005394_taste/olfaction_phenotype1.30120783
36MP0005499_abnormal_olfactory_system1.30120783
37MP0000678_abnormal_parathyroid_gland1.25630362
38MP0003943_abnormal_hepatobiliary_system1.24520764
39MP0002735_abnormal_chemical_nociception1.20837763
40MP0008995_early_reproductive_senescence1.17759872
41MP0005671_abnormal_response_to1.15477796
42MP0002249_abnormal_larynx_morphology1.12292096
43MP0003698_abnormal_male_reproductive1.11655854
44MP0004885_abnormal_endolymph1.10514014
45MP0004142_abnormal_muscle_tone1.09083053
46MP0002160_abnormal_reproductive_system1.04450563
47MP0001835_abnormal_antigen_presentation1.04368588
48MP0005397_hematopoietic_system_phenotyp1.02251299
49MP0001545_abnormal_hematopoietic_system1.02251299
50MP0005389_reproductive_system_phenotype1.02101655
51MP0001664_abnormal_digestion1.00949405
52MP0001929_abnormal_gametogenesis0.99963096
53MP0005551_abnormal_eye_electrophysiolog0.98137924
54MP0010386_abnormal_urinary_bladder0.98027194
55MP0002210_abnormal_sex_determination0.94314171
56MP0005645_abnormal_hypothalamus_physiol0.93175694
57MP0006054_spinal_hemorrhage0.93017119
58MP0003252_abnormal_bile_duct0.91795720
59MP0002277_abnormal_respiratory_mucosa0.91698967
60MP0001984_abnormal_olfaction0.90929287
61MP0000372_irregular_coat_pigmentation0.87364525
62MP0001905_abnormal_dopamine_level0.86085725
63MP0004147_increased_porphyrin_level0.86031801
64MP0000653_abnormal_sex_gland0.85911701
65MP0001486_abnormal_startle_reflex0.84172310
66MP0009384_cardiac_valve_regurgitation0.82059145
67MP0010329_abnormal_lipoprotein_level0.81219968
68MP0000049_abnormal_middle_ear0.79906536
69MP0005464_abnormal_platelet_physiology0.79702443
70MP0000689_abnormal_spleen_morphology0.79414957
71MP0001145_abnormal_male_reproductive0.76974343
72MP0000631_abnormal_neuroendocrine_gland0.76628787
73MP0005253_abnormal_eye_physiology0.74638671
74MP0003195_calcinosis0.73658036
75MP0005410_abnormal_fertilization0.73372175
76MP0001293_anophthalmia0.72307319
77MP0002398_abnormal_bone_marrow0.70530905
78MP0001324_abnormal_eye_pigmentation0.68969232
79MP0009250_abnormal_appendicular_skeleto0.68664693
80MP0002166_altered_tumor_susceptibility0.68346394
81MP0001270_distended_abdomen0.68199785
82MP0005365_abnormal_bile_salt0.68184265
83MP0009278_abnormal_bone_marrow0.67855137
84MP0001919_abnormal_reproductive_system0.67509166
85MP0000639_abnormal_adrenal_gland0.66890060
86MP0002722_abnormal_immune_system0.64898143
87MP0000703_abnormal_thymus_morphology0.64565241
88MP0001790_abnormal_immune_system0.63453701
89MP0005387_immune_system_phenotype0.63453701
90MP0005220_abnormal_exocrine_pancreas0.61907206
91MP0002006_tumorigenesis0.61114178
92MP0001800_abnormal_humoral_immune0.60080616
93MP0002109_abnormal_limb_morphology0.59490093
94MP0003806_abnormal_nucleotide_metabolis0.59050022
95MP0001970_abnormal_pain_threshold0.58189112
96MP0002837_dystrophic_cardiac_calcinosis0.57583928
97MP0003718_maternal_effect0.57305443
98MP0005535_abnormal_body_temperature0.56580835
99MP0003724_increased_susceptibility_to0.56142444
100MP0000778_abnormal_nervous_system0.55133642

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.99399574
2Acute lymphatic leukemia (HP:0006721)4.84135395
3Rhabdomyosarcoma (HP:0002859)4.34102407
4Metaphyseal dysplasia (HP:0100255)4.22762153
5Tubulointerstitial nephritis (HP:0001970)3.51599463
6Colon cancer (HP:0003003)3.46706541
7Abnormality of B cell number (HP:0010975)3.44860336
8B lymphocytopenia (HP:0010976)3.31274510
9Constricted visual fields (HP:0001133)3.28964417
10Abnormal rod and cone electroretinograms (HP:0008323)3.21995855
11Papilledema (HP:0001085)3.19020935
12Dyschromatopsia (HP:0007641)3.16878361
13Stenosis of the external auditory canal (HP:0000402)2.93831329
14Abnormality of the phalanges of the 2nd finger (HP:0009541)2.92593438
15Abnormal hemoglobin (HP:0011902)2.89935440
16Decreased central vision (HP:0007663)2.83775220
17Abolished electroretinogram (ERG) (HP:0000550)2.77234389
18Gonadal dysgenesis (HP:0000133)2.75574776
19Thyroid-stimulating hormone excess (HP:0002925)2.74927471
20Retinal dysplasia (HP:0007973)2.71621377
21Neoplasm of striated muscle (HP:0009728)2.64364140
22Attenuation of retinal blood vessels (HP:0007843)2.64214841
23Brushfield spots (HP:0001088)2.61821859
24Central scotoma (HP:0000603)2.53270832
25Medial flaring of the eyebrow (HP:0010747)2.52426235
26Neonatal respiratory distress (HP:0002643)2.48501449
27Type II lissencephaly (HP:0007260)2.34009958
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33914693
29Abnormality of macular pigmentation (HP:0008002)2.32056559
30Amyotrophic lateral sclerosis (HP:0007354)2.31981683
31Abnormality of midbrain morphology (HP:0002418)2.26848352
32Molar tooth sign on MRI (HP:0002419)2.26848352
33Short middle phalanx of the 5th finger (HP:0004220)2.24955024
34Scotoma (HP:0000575)2.23487828
35Increased hepatocellular lipid droplets (HP:0006565)2.22054546
36Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.17424420
37Increased serum lactate (HP:0002151)2.16688255
38Reduced antithrombin III activity (HP:0001976)2.16186109
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.11762353
40Absent/shortened dynein arms (HP:0200106)2.11762353
41Microvesicular hepatic steatosis (HP:0001414)2.10875129
42Urinary urgency (HP:0000012)2.07222844
43Hypochromic microcytic anemia (HP:0004840)2.06724198
44Prolonged bleeding time (HP:0003010)2.06647398
45Chronic otitis media (HP:0000389)2.05796465
4611 pairs of ribs (HP:0000878)2.05666688
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02079025
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.02079025
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01785063
50Abnormality of alanine metabolism (HP:0010916)2.01785063
51Hyperalaninemia (HP:0003348)2.01785063
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.01005098
53Limb hypertonia (HP:0002509)1.98561862
54Increased CSF lactate (HP:0002490)1.95511831
55Mitochondrial inheritance (HP:0001427)1.93915538
56Reticulocytopenia (HP:0001896)1.93264697
57Optic disc pallor (HP:0000543)1.92849687
58Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.91811780
59Congenital primary aphakia (HP:0007707)1.91740085
603-Methylglutaconic aciduria (HP:0003535)1.89492997
61Abnormality of the corticospinal tract (HP:0002492)1.88820314
62Lipid accumulation in hepatocytes (HP:0006561)1.88428960
63Abnormality of the 2nd finger (HP:0004100)1.87036804
64Nephronophthisis (HP:0000090)1.86928027
65Delayed CNS myelination (HP:0002188)1.84893123
66Nephrogenic diabetes insipidus (HP:0009806)1.84093228
67Pancreatic cysts (HP:0001737)1.82980983
68Gait imbalance (HP:0002141)1.82895198
69Metabolic acidosis (HP:0001942)1.82305441
70Hyperglycinemia (HP:0002154)1.82160284
71Congenital stationary night blindness (HP:0007642)1.82044925
72Hip dysplasia (HP:0001385)1.80630798
73Female pseudohermaphroditism (HP:0010458)1.79746731
74Delayed myelination (HP:0012448)1.79610847
75Hepatocellular necrosis (HP:0001404)1.79579492
76Hepatic necrosis (HP:0002605)1.79277750
77Severe global developmental delay (HP:0011344)1.78731462
78Panhypogammaglobulinemia (HP:0003139)1.77690024
79Severe muscular hypotonia (HP:0006829)1.76506373
80Impaired vibration sensation in the lower limbs (HP:0002166)1.75815154
81Tubular atrophy (HP:0000092)1.75502017
82Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.74790292
83Facial hemangioma (HP:0000329)1.73519351
84Breast carcinoma (HP:0003002)1.72823460
85Epiphyseal stippling (HP:0010655)1.72704552
86Asplenia (HP:0001746)1.72109531
87Respiratory difficulties (HP:0002880)1.71689071
88Medulloblastoma (HP:0002885)1.71292303
89Encephalitis (HP:0002383)1.70487517
90Triphalangeal thumb (HP:0001199)1.70375156
91Stomach cancer (HP:0012126)1.70235446
92Primary adrenal insufficiency (HP:0008207)1.68572722
93Pancreatic fibrosis (HP:0100732)1.68546989
94Pallor (HP:0000980)1.67417484
95Tetany (HP:0001281)1.67024397
96Thickened nuchal skin fold (HP:0000474)1.66561543
97Prostate neoplasm (HP:0100787)1.65663185
98Primitive neuroectodermal tumor (HP:0030065)1.65465210
99Neuroblastic tumors (HP:0004376)1.65465210
100Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.65465210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.50730113
2MAP4K23.62339803
3NLK3.36303666
4ACVR1B2.99498748
5EIF2AK32.48751379
6FLT32.48229049
7CDK32.30057427
8CSNK1G12.06378243
9NUAK12.04981394
10MUSK1.99649828
11TXK1.93392446
12RPS6KA41.88590319
13MAPK71.83999536
14KIT1.83640241
15PINK11.77505674
16MKNK11.69288901
17WNK31.58763569
18SGK21.53337380
19DYRK1A1.43758527
20ERBB31.40927946
21MAP3K41.35213830
22MAP3K61.35166062
23PIK3CG1.33603577
24MAPK131.31862702
25MAP4K11.29557753
26BMPR1B1.29371458
27TAF11.27600340
28TEC1.23239714
29BCKDK1.22089044
30DAPK21.20471204
31EIF2AK21.18475168
32CASK1.17650030
33MATK1.12096281
34CSF1R1.11278866
35NEK21.11143053
36CDC71.09627765
37PLK41.06655312
38TESK21.05906013
39KDR1.04719674
40SGK4941.04098014
41SGK2231.04098014
42TRIM281.03883130
43SYK1.03511363
44WNK41.02477329
45ZAK1.02425812
46HIPK21.00050210
47VRK20.98045109
48MAP3K50.97506162
49PRKG20.96253121
50CDK60.94401167
51BTK0.89315538
52GRK10.89074402
53HCK0.86246920
54TNK20.84573955
55SCYL20.83140602
56TAOK30.81220896
57MAP2K70.80207764
58STK390.79170409
59RPS6KB20.76363651
60PLK20.76341984
61BCR0.73303592
62PAK20.71325126
63PBK0.71078208
64FRK0.70777860
65MAP2K40.70550165
66DAPK10.67393618
67DYRK1B0.63206769
68SGK30.62743416
69CSNK1G30.60175344
70VRK10.57343353
71CSNK1G20.55882485
72IKBKE0.54590169
73PRKCE0.53559455
74CCNB10.52332025
75MKNK20.49964623
76MST40.48535514
77SRPK10.48181015
78DYRK20.45341143
79RPS6KA50.43690392
80DYRK30.43471254
81PRKCQ0.43216788
82ADRBK20.41955287
83RPS6KB10.41516511
84CAMK10.40326315
85TGFBR10.40087878
86OBSCN0.38047280
87LYN0.36476504
88MAP2K60.35064838
89LCK0.34113740
90CDK40.33894934
91RPS6KA60.33652607
92RPS6KC10.31771660
93RPS6KL10.31771660
94PKN20.29523462
95ITK0.29095674
96IKBKB0.28892456
97DAPK30.28725514
98TBK10.28706768
99CSNK2A10.28509950
100FES0.27248869

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.65784628
2Non-homologous end-joining_Homo sapiens_hsa034502.44404263
3Cysteine and methionine metabolism_Homo sapiens_hsa002702.27119621
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.18836930
5Proteasome_Homo sapiens_hsa030502.06658279
6Primary immunodeficiency_Homo sapiens_hsa053402.03547708
7Olfactory transduction_Homo sapiens_hsa047402.02584191
8Propanoate metabolism_Homo sapiens_hsa006401.95387457
9Glycerophospholipid metabolism_Homo sapiens_hsa005641.86411433
10Peroxisome_Homo sapiens_hsa041461.85976179
11Linoleic acid metabolism_Homo sapiens_hsa005911.85411768
12Homologous recombination_Homo sapiens_hsa034401.85357156
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72204266
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71327127
15Butanoate metabolism_Homo sapiens_hsa006501.69167637
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68097295
17RNA degradation_Homo sapiens_hsa030181.64594432
18Basal transcription factors_Homo sapiens_hsa030221.62716156
19Sulfur relay system_Homo sapiens_hsa041221.61396344
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59232309
21Parkinsons disease_Homo sapiens_hsa050121.58499682
22Ether lipid metabolism_Homo sapiens_hsa005651.58420028
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58162010
24RNA transport_Homo sapiens_hsa030131.54757404
25Oxidative phosphorylation_Homo sapiens_hsa001901.53889991
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51263817
27Taste transduction_Homo sapiens_hsa047421.48608065
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46925087
29Phototransduction_Homo sapiens_hsa047441.43369223
30African trypanosomiasis_Homo sapiens_hsa051431.40027758
31Sulfur metabolism_Homo sapiens_hsa009201.39407126
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39388162
33Protein export_Homo sapiens_hsa030601.37395248
34RNA polymerase_Homo sapiens_hsa030201.32876323
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29011304
36Platelet activation_Homo sapiens_hsa046111.24735773
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.24475244
38Regulation of autophagy_Homo sapiens_hsa041401.23693279
39Base excision repair_Homo sapiens_hsa034101.23628747
40Tryptophan metabolism_Homo sapiens_hsa003801.22290618
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.21414420
42Fanconi anemia pathway_Homo sapiens_hsa034601.20743181
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19761873
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19158270
45Chemical carcinogenesis_Homo sapiens_hsa052041.11198062
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08401865
47Hematopoietic cell lineage_Homo sapiens_hsa046401.07554985
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04010686
49Retinol metabolism_Homo sapiens_hsa008301.01628154
50Long-term depression_Homo sapiens_hsa047301.01534255
51Arachidonic acid metabolism_Homo sapiens_hsa005901.00120019
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97962736
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97362417
54Huntingtons disease_Homo sapiens_hsa050160.96459792
55mRNA surveillance pathway_Homo sapiens_hsa030150.95098178
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.93499372
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.92726729
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92567194
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92450408
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92260479
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89921150
62Renin secretion_Homo sapiens_hsa049240.86071652
63Morphine addiction_Homo sapiens_hsa050320.83065351
64Circadian entrainment_Homo sapiens_hsa047130.82608027
65Purine metabolism_Homo sapiens_hsa002300.81572602
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80886442
67Pyrimidine metabolism_Homo sapiens_hsa002400.80474283
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79680889
69Selenocompound metabolism_Homo sapiens_hsa004500.78073544
70Antigen processing and presentation_Homo sapiens_hsa046120.78022065
71Dorso-ventral axis formation_Homo sapiens_hsa043200.77333762
72Serotonergic synapse_Homo sapiens_hsa047260.72797363
73Dopaminergic synapse_Homo sapiens_hsa047280.69567949
74Salivary secretion_Homo sapiens_hsa049700.68278640
75Amphetamine addiction_Homo sapiens_hsa050310.67052797
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65423255
77Glutamatergic synapse_Homo sapiens_hsa047240.63740737
78Nicotine addiction_Homo sapiens_hsa050330.62417003
79Metabolic pathways_Homo sapiens_hsa011000.61781202
80Mismatch repair_Homo sapiens_hsa034300.61208583
81Steroid biosynthesis_Homo sapiens_hsa001000.61105511
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60122573
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58243535
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.55919726
85Glutathione metabolism_Homo sapiens_hsa004800.48866516
86GABAergic synapse_Homo sapiens_hsa047270.48862710
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47022959
88Herpes simplex infection_Homo sapiens_hsa051680.45211943
89beta-Alanine metabolism_Homo sapiens_hsa004100.44664735
90Nucleotide excision repair_Homo sapiens_hsa034200.44353226
91Cocaine addiction_Homo sapiens_hsa050300.43282493
92Shigellosis_Homo sapiens_hsa051310.37244856
93Pyruvate metabolism_Homo sapiens_hsa006200.36262459
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35531963
95Oxytocin signaling pathway_Homo sapiens_hsa049210.33418909
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31094347
97Ovarian steroidogenesis_Homo sapiens_hsa049130.30447694
98Cholinergic synapse_Homo sapiens_hsa047250.29511675
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28276602
100Glucagon signaling pathway_Homo sapiens_hsa049220.27473661

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »