LVRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1estrogen biosynthetic process (GO:0006703)9.97354100
2positive regulation of action potential (GO:0045760)8.21267706
3tachykinin receptor signaling pathway (GO:0007217)7.74567938
4regulation of gonadotropin secretion (GO:0032276)7.49144402
5positive regulation of digestive system process (GO:0060456)7.04006957
6protein heterotrimerization (GO:0070208)6.90908836
7triglyceride catabolic process (GO:0019433)6.84787948
8regulation of glucocorticoid secretion (GO:2000849)6.30369742
9acylglycerol catabolic process (GO:0046464)6.17660579
10neutral lipid catabolic process (GO:0046461)6.17660579
11collagen fibril organization (GO:0030199)6.17400926
12regulation of corticosteroid hormone secretion (GO:2000846)6.06705413
13response to follicle-stimulating hormone (GO:0032354)5.97857445
14positive regulation of steroid hormone secretion (GO:2000833)5.95414007
15female pregnancy (GO:0007565)5.22973299
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.14469670
17negative regulation of heart rate (GO:0010459)5.13294673
18glucocorticoid biosynthetic process (GO:0006704)4.95060249
19actin-myosin filament sliding (GO:0033275)4.83341275
20muscle filament sliding (GO:0030049)4.83341275
21collagen metabolic process (GO:0032963)4.76224115
22keratan sulfate catabolic process (GO:0042340)4.70447358
23positive regulation of synaptic transmission, GABAergic (GO:0032230)4.65285179
24collagen catabolic process (GO:0030574)4.63981712
25extracellular fibril organization (GO:0043206)4.60399862
26positive regulation of renal sodium excretion (GO:0035815)4.58735028
27fatty acid homeostasis (GO:0055089)4.58163117
28multicellular organismal macromolecule metabolic process (GO:0044259)4.54042013
29plasma membrane repair (GO:0001778)4.51281458
30glycerolipid catabolic process (GO:0046503)4.49671529
31endocrine hormone secretion (GO:0060986)4.46464581
32bone trabecula formation (GO:0060346)4.45799640
33extracellular matrix assembly (GO:0085029)4.44101306
34lipid storage (GO:0019915)4.39442337
35multicellular organismal metabolic process (GO:0044236)4.34429940
36prostate gland growth (GO:0060736)4.31335738
37negative regulation of macrophage differentiation (GO:0045650)4.31124869
38multicellular organismal catabolic process (GO:0044243)4.30584397
39multi-multicellular organism process (GO:0044706)4.29513872
40sequestering of extracellular ligand from receptor (GO:0035581)4.29082785
41diacylglycerol metabolic process (GO:0046339)4.23082489
42skeletal muscle adaptation (GO:0043501)4.22642079
43regulation of cholesterol storage (GO:0010885)4.18935100
44estrogen metabolic process (GO:0008210)4.17821972
45regulation of steroid hormone secretion (GO:2000831)4.17180394
46actin-mediated cell contraction (GO:0070252)4.14757004
47regulation of skeletal muscle contraction (GO:0014819)4.07840831
48fibril organization (GO:0097435)4.01838824
49androgen biosynthetic process (GO:0006702)4.01495690
50negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.99429978
51endodermal cell differentiation (GO:0035987)3.95555324
52extracellular matrix disassembly (GO:0022617)3.92592317
53positive regulation of fatty acid beta-oxidation (GO:0032000)3.84839497
54response to parathyroid hormone (GO:0071107)3.83244534
55skin morphogenesis (GO:0043589)3.79853840
56biotin metabolic process (GO:0006768)3.77571397
57brown fat cell differentiation (GO:0050873)3.75684813
58regulation of cAMP-dependent protein kinase activity (GO:2000479)3.75448746
59multi-organism reproductive process (GO:0044703)3.73698364
60regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.72140048
61cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.71424116
62glycerol metabolic process (GO:0006071)3.70920377
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.69514351
64transcytosis (GO:0045056)3.69397875
65regulation of endocrine process (GO:0044060)3.67687214
66regulation of action potential (GO:0098900)3.67452321
67triglyceride biosynthetic process (GO:0019432)3.62471114
68polyol transport (GO:0015791)3.61778638
69chondrocyte proliferation (GO:0035988)3.59923796
70response to dietary excess (GO:0002021)3.59663824
71cardiac myofibril assembly (GO:0055003)3.59517082
72response to phenylpropanoid (GO:0080184)3.56105292
73epithelial cell-cell adhesion (GO:0090136)3.55604455
74negative regulation of fatty acid transport (GO:2000192)3.53366145
75vitamin transmembrane transport (GO:0035461)3.52821274
76white fat cell differentiation (GO:0050872)3.51458979
77myelination in peripheral nervous system (GO:0022011)3.49735574
78peripheral nervous system axon ensheathment (GO:0032292)3.49735574
79positive regulation of fatty acid oxidation (GO:0046321)3.47722144
80positive regulation of insulin receptor signaling pathway (GO:0046628)3.44258053
81low-density lipoprotein particle clearance (GO:0034383)3.42944675
82actin filament-based movement (GO:0030048)3.42935407
83ovulation from ovarian follicle (GO:0001542)3.42645167
84acylglycerol biosynthetic process (GO:0046463)3.41873093
85neutral lipid biosynthetic process (GO:0046460)3.41873093
86myofibril assembly (GO:0030239)3.40130467
87basement membrane organization (GO:0071711)3.38960304
88regulation of renal sodium excretion (GO:0035813)3.38164086
89regulation of glycogen (starch) synthase activity (GO:2000465)3.38163215
90positive regulation of cholesterol efflux (GO:0010875)3.33964721
91regulation of protein kinase A signaling (GO:0010738)3.33867921
92negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.30835164
93regulation of p38MAPK cascade (GO:1900744)3.30585286
94positive regulation of glomerulus development (GO:0090193)3.29270862
95positive regulation of protein kinase C signaling (GO:0090037)3.28813605
96positive regulation of cellular response to insulin stimulus (GO:1900078)3.28162224
97negative regulation of stress fiber assembly (GO:0051497)3.25841765
98positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.24074199
99plasma lipoprotein particle clearance (GO:0034381)3.22970642
100negative regulation of Rho protein signal transduction (GO:0035024)3.20724198
101negative regulation of heart growth (GO:0061117)3.19719692
102negative regulation of cardiac muscle tissue growth (GO:0055022)3.19719692
103skeletal muscle contraction (GO:0003009)3.17274241
104regulation of digestive system process (GO:0044058)3.17254692
105sarcomere organization (GO:0045214)3.16253566
106alditol metabolic process (GO:0019400)3.15695409
107negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.14900646
108triglyceride metabolic process (GO:0006641)3.13199720
109apoptotic cell clearance (GO:0043277)3.12266923
110negative regulation of chondrocyte differentiation (GO:0032331)3.12186635
111retina vasculature morphogenesis in camera-type eye (GO:0061299)3.11548839
112glomerular basement membrane development (GO:0032836)3.10709504
113sarcoplasmic reticulum calcium ion transport (GO:0070296)3.10172106
114negative regulation of blood circulation (GO:1903523)3.08917911
115axon extension involved in axon guidance (GO:0048846)3.06370989
116neuron projection extension involved in neuron projection guidance (GO:1902284)3.06370989
117androgen metabolic process (GO:0008209)3.05078714
118negative regulation of cartilage development (GO:0061037)3.04942679
119positive regulation of glycogen biosynthetic process (GO:0045725)3.03478564
120JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.02332552
121positive regulation of myotube differentiation (GO:0010831)3.01387528
122regulation of macrophage derived foam cell differentiation (GO:0010743)2.99639468
123positive regulation of glycolytic process (GO:0045821)2.98688591
124regulation of fatty acid beta-oxidation (GO:0031998)2.98009587
125cornea development in camera-type eye (GO:0061303)2.97261350
126positive regulation of p38MAPK cascade (GO:1900745)2.94225850
127CDP-diacylglycerol biosynthetic process (GO:0016024)2.92815221
128positive regulation of growth hormone secretion (GO:0060124)2.92661831
129negative regulation of lipid storage (GO:0010888)2.92018915
130biomineral tissue development (GO:0031214)2.91593524
131neuronal ion channel clustering (GO:0045161)2.90779998
132phospholipid homeostasis (GO:0055091)2.88461922
133mesenchymal-epithelial cell signaling (GO:0060638)2.88199575
134acylglycerol metabolic process (GO:0006639)2.87121508
135positive regulation of lipid storage (GO:0010884)2.86315834
136trabecula formation (GO:0060343)2.85766462
137carnitine shuttle (GO:0006853)2.85447556
138hemidesmosome assembly (GO:0031581)2.84516339
139regulation of excretion (GO:0044062)2.83733553
140vascular endothelial growth factor signaling pathway (GO:0038084)2.83350599
141response to vitamin E (GO:0033197)2.82653381
142response to gonadotropin (GO:0034698)2.82647031
143glomerular filtration (GO:0003094)2.82519028
144neutral lipid metabolic process (GO:0006638)2.81915954
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.81167759
146extracellular matrix organization (GO:0030198)2.81114533
147negative regulation of metanephros development (GO:0072217)2.80819832
148extracellular structure organization (GO:0043062)2.80436350
149lymphangiogenesis (GO:0001946)2.80225715
150cellular response to interferon-alpha (GO:0035457)2.78957577
151outer ear morphogenesis (GO:0042473)2.77725810
152negative regulation of gluconeogenesis (GO:0045721)2.76845108
153positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.76697514
154NADH metabolic process (GO:0006734)2.75893281
155regulation of fatty acid oxidation (GO:0046320)2.75609063
156metanephric mesenchyme development (GO:0072075)2.75511331
157negative regulation of amino acid transport (GO:0051956)2.74073275
158endothelial cell morphogenesis (GO:0001886)2.72201477
159ethanol oxidation (GO:0006069)2.72129042
160negative regulation of norepinephrine secretion (GO:0010700)2.71752138
161positive regulation of cholesterol transport (GO:0032376)2.71659070
162positive regulation of sterol transport (GO:0032373)2.71659070
163negative regulation of potassium ion transmembrane transport (GO:1901380)2.71373839
164cell-substrate junction assembly (GO:0007044)2.71218104
165regulation of lipoprotein metabolic process (GO:0050746)2.71056187
166alpha-linolenic acid metabolic process (GO:0036109)2.70999722
167fatty acid transmembrane transport (GO:1902001)2.69240898
168endochondral ossification (GO:0001958)2.68902393
169replacement ossification (GO:0036075)2.68902393
170lipid particle organization (GO:0034389)2.67038029
171craniofacial suture morphogenesis (GO:0097094)2.66450054
172renal filtration (GO:0097205)2.63535845
173myoblast migration (GO:0051451)2.61905809
174regulation of cartilage development (GO:0061035)2.61031592
175hippo signaling (GO:0035329)2.60137994
176negative regulation of catenin import into nucleus (GO:0035414)2.59359095
177positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58413201
178organ induction (GO:0001759)2.55172963
179regulation of sequestering of triglyceride (GO:0010889)2.54063764
180positive regulation of Rho protein signal transduction (GO:0035025)2.53753370
181blood vessel maturation (GO:0001955)2.53472521
182actomyosin structure organization (GO:0031032)2.52948464
183skeletal muscle fiber development (GO:0048741)2.52437771
184anatomical structure regression (GO:0060033)2.51385176
185positive regulation of glycogen metabolic process (GO:0070875)2.48509348
186growth hormone receptor signaling pathway (GO:0060396)2.47022988
187iron ion import (GO:0097286)2.44930432
188muscle cell fate commitment (GO:0042693)2.44596308
189myoblast fusion (GO:0007520)2.43125342
190regulation of chondrocyte differentiation (GO:0032330)2.42745591
191regulation of extracellular matrix disassembly (GO:0010715)2.42534258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.79777243
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.37542744
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.10782601
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.77648075
5CLOCK_20551151_ChIP-Seq_293T_Human3.29019328
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.18962354
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.88164747
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.58679048
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.58447734
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46758023
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.42594473
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31610791
13GATA1_22025678_ChIP-Seq_K562_Human2.30782469
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28671832
15CJUN_26792858_Chip-Seq_BT549_Human2.24721759
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.16230089
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04970860
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.01423019
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99993165
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95227121
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95148736
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94129974
23GBX2_23144817_ChIP-Seq_PC3_Human1.89239219
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86563291
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.86080462
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81726200
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81475705
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80412819
29TBX20_22328084_ChIP-Seq_HEART_Mouse1.79623919
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.79623919
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73642425
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.72907529
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67683257
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67683257
35TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.63551210
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63081138
37FUS_26573619_Chip-Seq_HEK293_Human1.61515407
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60425322
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.58185937
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56992933
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.56369105
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55680866
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.51918829
44BRD4_25478319_ChIP-Seq_HGPS_Human1.51610857
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48879468
46RXR_22108803_ChIP-Seq_LS180_Human1.44335072
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.43180387
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41402282
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39173663
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38465574
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38465574
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36563652
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34404666
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.34278468
55ER_23166858_ChIP-Seq_MCF-7_Human1.33161323
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33013103
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32558556
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32235799
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.31916037
60P300_19829295_ChIP-Seq_ESCs_Human1.31113231
61IGF1R_20145208_ChIP-Seq_DFB_Human1.30741983
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29833887
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29454578
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28245177
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28141992
66PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.26724419
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.25126890
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24537661
69TP53_18474530_ChIP-ChIP_U2OS_Human1.24274923
70DROSHA_22980978_ChIP-Seq_HELA_Human1.24000977
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.23880061
72TP53_16413492_ChIP-PET_HCT116_Human1.23775492
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.22982081
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.22444193
75TAF15_26573619_Chip-Seq_HEK293_Human1.21352992
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20944623
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20440825
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.20113094
79EGR1_19032775_ChIP-ChIP_M12_Human1.18348214
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18282254
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.17750348
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17352743
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17258235
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.16857487
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.16103349
86ZNF263_19887448_ChIP-Seq_K562_Human1.15158364
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14464583
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.14388172
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14116542
90* SMAD4_21799915_ChIP-Seq_A2780_Human1.14096071
91KDM2B_26808549_Chip-Seq_K562_Human1.14063251
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14011872
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13598118
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13560535
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13560535
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13342923
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13190178
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.12011548
99SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11849439
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11688283
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11421095
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11375072
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11159310
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10717723
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10627027
106AR_21572438_ChIP-Seq_LNCaP_Human1.10208005
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09951972
108STAT3_23295773_ChIP-Seq_U87_Human1.09476764
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09031287
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08909017
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08227709
112MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08072553
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07271099
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.06407386
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05024756
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04332877
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01783948
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01591269
119RUNX2_22187159_ChIP-Seq_PCA_Human1.01008228
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00983790
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00691576
122FOXO3_23340844_ChIP-Seq_DLD1_Human1.00252925
123Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99972488
124AR_25329375_ChIP-Seq_VCAP_Human0.99657858
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99556809
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98138543
127CBP_20019798_ChIP-Seq_JUKART_Human0.97639958
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97639958
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.97382277
130AHR_22903824_ChIP-Seq_MCF-7_Human0.97185460
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96732650
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96707890
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96369556
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96261700
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95788257
136TCF4_23295773_ChIP-Seq_U87_Human0.95559063
137RNF2_27304074_Chip-Seq_ESCs_Mouse0.95513005
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94791737
139RACK7_27058665_Chip-Seq_MCF-7_Human0.94333730
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91961180
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.91797425
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.91771297
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91552931
144KDM2B_26808549_Chip-Seq_DND41_Human0.90891395
145SA1_22415368_ChIP-Seq_MEFs_Mouse0.89023798
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.87847395
147TP63_23658742_ChIP-Seq_EP156T_Human0.87799295
148BCAT_22108803_ChIP-Seq_LS180_Human0.87677762
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87676813
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.87426660
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86975704
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86761730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.76703195
2MP0005275_abnormal_skin_tensile6.09353427
3MP0005503_abnormal_tendon_morphology5.29631933
4MP0010386_abnormal_urinary_bladder4.66888382
5MP0000751_myopathy3.87136067
6MP0003705_abnormal_hypodermis_morpholog3.35701579
7MP0003959_abnormal_lean_body2.97592162
8MP0009697_abnormal_copulation2.87791023
9MP0004272_abnormal_basement_membrane2.83484658
10MP0005257_abnormal_intraocular_pressure2.67537669
11MP0001958_emphysema2.66416443
12MP0005379_endocrine/exocrine_gland_phen2.61182217
13MP0002108_abnormal_muscle_morphology2.52537614
14MP0002837_dystrophic_cardiac_calcinosis2.26034575
15MP0005647_abnormal_sex_gland2.19445183
16MP0000750_abnormal_muscle_regeneration2.18070394
17MP0003279_aneurysm2.15105915
18MP0000749_muscle_degeneration2.13576181
19MP0004145_abnormal_muscle_electrophysio2.10772491
20MP0002876_abnormal_thyroid_physiology2.10603986
21MP0006276_abnormal_autonomic_nervous2.04891853
22MP0010329_abnormal_lipoprotein_level2.01636583
23MP0002970_abnormal_white_adipose1.94346409
24MP0002060_abnormal_skin_morphology1.88157993
25MP0000733_abnormal_muscle_development1.87808143
26MP0004130_abnormal_muscle_cell1.85806935
27MP0005535_abnormal_body_temperature1.84373696
28MP0005623_abnormal_meninges_morphology1.83640396
29MP0004087_abnormal_muscle_fiber1.81365390
30MP0003646_muscle_fatigue1.77557080
31MP0005670_abnormal_white_adipose1.76212522
32MP0005369_muscle_phenotype1.71741105
33MP0001879_abnormal_lymphatic_vessel1.71363619
34MP0002106_abnormal_muscle_physiology1.71046215
35MP0005508_abnormal_skeleton_morphology1.69482744
36MP0003879_abnormal_hair_cell1.66337973
37MP0009384_cardiac_valve_regurgitation1.66063655
38MP0000759_abnormal_skeletal_muscle1.64811666
39MP0006054_spinal_hemorrhage1.63933071
40MP0004084_abnormal_cardiac_muscle1.60326392
41MP0005666_abnormal_adipose_tissue1.51890882
42MP0002163_abnormal_gland_morphology1.51018848
43MP0003566_abnormal_cell_adhesion1.46475339
44MP0000747_muscle_weakness1.45992711
45MP0000013_abnormal_adipose_tissue1.43985971
46MP0009250_abnormal_appendicular_skeleto1.42964533
47MP0005448_abnormal_energy_balance1.39180683
48MP0004019_abnormal_vitamin_homeostasis1.39135838
49MP0004036_abnormal_muscle_relaxation1.38685877
50MP0005076_abnormal_cell_differentiation1.37954278
51MP0002118_abnormal_lipid_homeostasis1.37741758
52MP0005452_abnormal_adipose_tissue1.36658389
53MP0003868_abnormal_feces_composition1.33322182
54MP0005330_cardiomyopathy1.33052241
55MP0003045_fibrosis1.32368964
56MP0004185_abnormal_adipocyte_glucose1.30606237
57MP0005375_adipose_tissue_phenotype1.27590773
58MP0005620_abnormal_muscle_contractility1.25930170
59MP0005187_abnormal_penis_morphology1.23288793
60MP0002896_abnormal_bone_mineralization1.21885944
61MP0003011_delayed_dark_adaptation1.21050939
62MP0003385_abnormal_body_wall1.18823241
63MP0001299_abnormal_eye_distance/1.18724150
64MP0001243_abnormal_dermal_layer1.18145081
65MP0004134_abnormal_chest_morphology1.10629457
66MP0003690_abnormal_glial_cell1.10136302
67MP0002168_other_aberrant_phenotype1.09742702
68MP0005646_abnormal_pituitary_gland1.09091827
69MP0003186_abnormal_redox_activity1.07185430
70MP0002115_abnormal_skeleton_extremities1.05802457
71MP0004215_abnormal_myocardial_fiber1.05560456
72MP0000003_abnormal_adipose_tissue1.04402218
73MP0000163_abnormal_cartilage_morphology1.04071434
74MP0004233_abnormal_muscle_weight1.02965531
75MP0001919_abnormal_reproductive_system1.02543669
76MP0000343_altered_response_to1.02454514
77MP0002295_abnormal_pulmonary_circulatio1.02248506
78MP0002269_muscular_atrophy1.01576919
79MP0010630_abnormal_cardiac_muscle1.01401451
80MP0005023_abnormal_wound_healing1.01056630
81MP0002971_abnormal_brown_adipose1.00744426
82MP0001440_abnormal_grooming_behavior1.00725049
83MP0002909_abnormal_adrenal_gland1.00477341
84MP0002972_abnormal_cardiac_muscle0.95084144
85MP0003191_abnormal_cellular_cholesterol0.94756258
86MP0002078_abnormal_glucose_homeostasis0.93344991
87MP0005390_skeleton_phenotype0.92805151
88MP0001544_abnormal_cardiovascular_syste0.92382064
89MP0005385_cardiovascular_system_phenoty0.92382064
90MP0010368_abnormal_lymphatic_system0.90712868
91MP0006138_congestive_heart_failure0.89941779
92MP0001756_abnormal_urination0.88263227
93MP0000767_abnormal_smooth_muscle0.87807452
94MP0002006_tumorigenesis0.87749883
95MP0002166_altered_tumor_susceptibility0.86922240
96MP0000534_abnormal_ureter_morphology0.86185045
97MP0002933_joint_inflammation0.85902330
98MP0009278_abnormal_bone_marrow0.85642927
99MP0002282_abnormal_trachea_morphology0.85593843
100MP0009115_abnormal_fat_cell0.85227510
101MP0001661_extended_life_span0.85095155
102MP0010030_abnormal_orbit_morphology0.84911657
103MP0004484_altered_response_of0.84244062
104MP0002089_abnormal_postnatal_growth/wei0.83592440
105MP0003091_abnormal_cell_migration0.82683583
106MP0001727_abnormal_embryo_implantation0.82050297
107MP0000579_abnormal_nail_morphology0.81840066
108MP0008775_abnormal_heart_ventricle0.80509739
109MP0003948_abnormal_gas_homeostasis0.79812553
110MP0000428_abnormal_craniofacial_morphol0.79182435
111MP0003953_abnormal_hormone_level0.79048597
112MP0005171_absent_coat_pigmentation0.79009084
113MP0003828_pulmonary_edema0.77798598
114MP0002113_abnormal_skeleton_development0.77020319
115MP0001542_abnormal_bone_strength0.76027529
116MP0003950_abnormal_plasma_membrane0.75956732
117MP0005595_abnormal_vascular_smooth0.73238450
118MP0005164_abnormal_response_to0.72750627
119MP0002128_abnormal_blood_circulation0.72428725
120MP0004782_abnormal_surfactant_physiolog0.71667206
121MP0003935_abnormal_craniofacial_develop0.71344993
122MP0002998_abnormal_bone_remodeling0.70964703
123MP0000609_abnormal_liver_physiology0.69780144
124MP0009780_abnormal_chondrocyte_physiolo0.68921499
125MP0002234_abnormal_pharynx_morphology0.67893596
126MP0003115_abnormal_respiratory_system0.67703831
127MP0000537_abnormal_urethra_morphology0.67299348
128MP0003936_abnormal_reproductive_system0.66169966
129MP0002109_abnormal_limb_morphology0.65541074
130MP0000432_abnormal_head_morphology0.64377475
131MP0001177_atelectasis0.64068981
132MP0003567_abnormal_fetal_cardiomyocyte0.63928658
133MP0003942_abnormal_urinary_system0.63894123
134MP0000762_abnormal_tongue_morphology0.63884824
135MP0005334_abnormal_fat_pad0.62819675
136MP0000266_abnormal_heart_morphology0.61878132
137MP0002877_abnormal_melanocyte_morpholog0.60110479
138MP0001533_abnormal_skeleton_physiology0.60009800
139MP0005409_darkened_coat_color0.59453078
140MP0000639_abnormal_adrenal_gland0.58855634
141MP0004085_abnormal_heartbeat0.55721794
142MP0009703_decreased_birth_body0.52777161
143MP0000230_abnormal_systemic_arterial0.52197837
144MP0001501_abnormal_sleep_pattern0.50205957
145MP0003941_abnormal_skin_development0.49889600
146MP0005584_abnormal_enzyme/coenzyme_acti0.49047340
147MP0003795_abnormal_bone_structure0.48900824
148MP0001881_abnormal_mammary_gland0.48473406
149MP0000647_abnormal_sebaceous_gland0.48310361

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)7.00249383
2Hypophosphatemic rickets (HP:0004912)6.80910283
3Papilledema (HP:0001085)6.74904910
4Protrusio acetabuli (HP:0003179)5.93528329
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.83585732
6Increased density of long bones (HP:0006392)5.72676465
7Increased connective tissue (HP:0009025)5.67795563
8Metaphyseal dysplasia (HP:0100255)5.55643145
9Ankle contracture (HP:0006466)5.42740998
10Muscle fiber splitting (HP:0003555)5.12827567
11Premature rupture of membranes (HP:0001788)5.07828151
12Slender build (HP:0001533)4.82451635
13Follicular hyperkeratosis (HP:0007502)4.78651948
14Oligomenorrhea (HP:0000876)4.31806233
15Broad metatarsal (HP:0001783)4.31003037
16Back pain (HP:0003418)4.20703621
17Spinal rigidity (HP:0003306)4.19259713
18Distal arthrogryposis (HP:0005684)4.18383182
19Acanthosis nigricans (HP:0000956)4.12404519
20Increased variability in muscle fiber diameter (HP:0003557)4.05749115
21Soft skin (HP:0000977)4.02524364
22Round ear (HP:0100830)3.92789123
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.86060218
24Facial diplegia (HP:0001349)3.79032995
25Abnormality of skeletal muscle fiber size (HP:0012084)3.78797512
26Muscle fiber inclusion bodies (HP:0100299)3.75015233
27Mildly elevated creatine phosphokinase (HP:0008180)3.71145476
28Aortic dissection (HP:0002647)3.61905741
29Myocardial infarction (HP:0001658)3.59614026
30Shallow orbits (HP:0000586)3.58768143
31Abnormality of the vertebral endplates (HP:0005106)3.58182305
32Atrophic scars (HP:0001075)3.56772230
33Hypertriglyceridemia (HP:0002155)3.54102946
34Rickets (HP:0002748)3.45300498
35Nemaline bodies (HP:0003798)3.43997711
36Cerebral aneurysm (HP:0004944)3.41341064
37Abnormality of calcium-phosphate metabolism (HP:0100530)3.37489034
38Fragile skin (HP:0001030)3.22572261
39Mitral valve prolapse (HP:0001634)3.20100737
40Craniofacial hyperostosis (HP:0004493)3.17859358
41Ulnar deviation of the wrist (HP:0003049)3.17239164
42Spondylolisthesis (HP:0003302)3.16665613
43Macroorchidism (HP:0000053)3.13523577
44Accelerated skeletal maturation (HP:0005616)3.12442525
45Bladder diverticulum (HP:0000015)3.09996962
46Exercise-induced myalgia (HP:0003738)3.02798995
47Hyporeflexia of lower limbs (HP:0002600)3.00323098
48Dilatation of the ascending aorta (HP:0005111)2.92700705
49Cranial hyperostosis (HP:0004437)2.90856480
50Thoracolumbar scoliosis (HP:0002944)2.86835076
51Spinal cord compression (HP:0002176)2.84430931
52Osteomalacia (HP:0002749)2.80690949
53Striae distensae (HP:0001065)2.77033962
54Aortic aneurysm (HP:0004942)2.73883817
55Wrist flexion contracture (HP:0001239)2.72984736
56Enlarged epiphyses (HP:0010580)2.65628119
57Femoral bowing (HP:0002980)2.65412947
58Calcaneovalgus deformity (HP:0001848)2.63599692
59Rectal prolapse (HP:0002035)2.62865292
60Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.62645613
61Abnormality of the calf musculature (HP:0001430)2.62135176
62Exercise-induced muscle cramps (HP:0003710)2.60832713
63Tibial bowing (HP:0002982)2.60156783
64Difficulty running (HP:0009046)2.59364153
65Polycythemia (HP:0001901)2.59154560
66Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.57687726
67Choanal stenosis (HP:0000452)2.55963941
68Persistence of primary teeth (HP:0006335)2.55031597
69Hip contracture (HP:0003273)2.54609898
70Cervical subluxation (HP:0003308)2.54213231
71Hyperextensible skin (HP:0000974)2.53921196
72Upper limb muscle weakness (HP:0003484)2.53231249
73Metaphyseal cupping (HP:0003021)2.52186524
74Wormian bones (HP:0002645)2.51271699
75Irregular vertebral endplates (HP:0003301)2.50508679
76Abnormality of the frontal sinuses (HP:0002687)2.49386295
77Genu recurvatum (HP:0002816)2.49293045
78Hypoplastic ischia (HP:0003175)2.46752075
79Peritonitis (HP:0002586)2.43455886
80Venous abnormality (HP:0002624)2.42431325
81Neonatal short-limb short stature (HP:0008921)2.42267708
82Myopathic facies (HP:0002058)2.40789464
83Insulin resistance (HP:0000855)2.38097179
84Deformed tarsal bones (HP:0008119)2.38059992
85Flat cornea (HP:0007720)2.37933189
86Absent frontal sinuses (HP:0002688)2.36337071
87Calf muscle hypertrophy (HP:0008981)2.36253456
88Limb-girdle muscle weakness (HP:0003325)2.32771230
89Joint laxity (HP:0001388)2.30484008
90Mesomelia (HP:0003027)2.27738177
91EMG: myopathic abnormalities (HP:0003458)2.25636210
92Muscle hypertrophy of the lower extremities (HP:0008968)2.25046497
93Absent phalangeal crease (HP:0006109)2.24880674
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23163148
95Sudden death (HP:0001699)2.22492569
96Blue sclerae (HP:0000592)2.21464940
97Venous insufficiency (HP:0005293)2.19968744
98Asymmetry of the thorax (HP:0001555)2.17878181
99Hypergonadotropic hypogonadism (HP:0000815)2.17638904
100Capillary hemangiomas (HP:0005306)2.16766367
101Hyperlipoproteinemia (HP:0010980)2.16271998
102Abnormal cortical bone morphology (HP:0003103)2.15638419
103Abnormality of the ischium (HP:0003174)2.15010014
104Mild short stature (HP:0003502)2.12653905
105Coxa vara (HP:0002812)2.12469089
106Osteoarthritis (HP:0002758)2.11748606
107Limited hip movement (HP:0008800)2.11704228
108Beaking of vertebral bodies (HP:0004568)2.10891224
109Lipoatrophy (HP:0100578)2.10407625
110Right ventricular cardiomyopathy (HP:0011663)2.10367705
111Small epiphyses (HP:0010585)2.08558899
112Hip dysplasia (HP:0001385)2.08213139
113Elbow flexion contracture (HP:0002987)2.07639973
114Hypophosphatemia (HP:0002148)2.06581719
115Abnormality of the calcaneus (HP:0008364)2.06349285
116Osteolytic defects of the hand bones (HP:0009699)2.04571930
117Osteolytic defects of the phalanges of the hand (HP:0009771)2.04571930
118Insulin-resistant diabetes mellitus (HP:0000831)2.03587567
119Wide anterior fontanel (HP:0000260)2.01652491
120Long foot (HP:0001833)2.01338531
121Neonatal hypoglycemia (HP:0001998)1.98280428
122Epidermoid cyst (HP:0200040)1.98181633
123Biconcave vertebral bodies (HP:0004586)1.96846049
124Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96062036
125Asymmetric septal hypertrophy (HP:0001670)1.95963929
126Nausea (HP:0002018)1.94965742
127Growth hormone excess (HP:0000845)1.94821280
128Esophageal varix (HP:0002040)1.94330050
129Prominent supraorbital ridges (HP:0000336)1.93582323
130Aneurysm (HP:0002617)1.93262078
131Scapular winging (HP:0003691)1.93198494
132Flared iliac wings (HP:0002869)1.92885016
133Bell-shaped thorax (HP:0001591)1.91165116
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.90636842
135Pigmentary retinal degeneration (HP:0001146)1.90631796
136Skin nodule (HP:0200036)1.90088584
137Proximal tubulopathy (HP:0000114)1.89898622
138Overgrowth (HP:0001548)1.89463995
139Tongue fasciculations (HP:0001308)1.89405432
140Generalized amyotrophy (HP:0003700)1.88842489
141Neck muscle weakness (HP:0000467)1.88754806
142Proximal amyotrophy (HP:0007126)1.87709575
143Vascular tortuosity (HP:0004948)1.86366090
144Lymphangioma (HP:0100764)1.85760794
145Trismus (HP:0000211)1.85608950
146Insidious onset (HP:0003587)1.84741677
147Termporal pattern (HP:0011008)1.84741677
148Abnormality of dentin (HP:0010299)1.83543993
149Myotonia (HP:0002486)1.83489051
150Muscle fibrillation (HP:0010546)1.83353601
151Ventricular tachycardia (HP:0004756)1.80330895
152Arterial tortuosity (HP:0005116)1.80326908
153Rhabdomyolysis (HP:0003201)1.80112407
154Vertebral compression fractures (HP:0002953)1.79477976
155Hypoplasia of the iris (HP:0007676)1.79348108
156Enlarged penis (HP:0000040)1.78697525
157Thin bony cortex (HP:0002753)1.77177326
158Ectopia lentis (HP:0001083)1.76698390
159Knee flexion contracture (HP:0006380)1.76681164
160Abnormality of fatty-acid metabolism (HP:0004359)1.76672512
161Hypoventilation (HP:0002791)1.76189583
162Protruding ear (HP:0000411)1.75967439
163Abnormal finger flexion creases (HP:0006143)1.75868731
164Ileus (HP:0002595)1.75572866
165Broad ribs (HP:0000885)1.74870632
166Abnormality of the acetabulum (HP:0003170)1.73933741
167Neoplasm of the heart (HP:0100544)1.73782974
168Difficulty climbing stairs (HP:0003551)1.73333342
169Infantile muscular hypotonia (HP:0008947)1.73287929
170Spinal cord lesions (HP:0100561)1.73243746
171Syringomyelia (HP:0003396)1.73243746
172Hypoalphalipoproteinemia (HP:0003233)1.71680855
173Cupped ribs (HP:0000887)1.70596333
174Abnormal eating behavior (HP:0100738)1.68740176
175Coronal craniosynostosis (HP:0004440)1.65494147
176Subcapsular cataract (HP:0000523)1.64955391
177Tetraparesis (HP:0002273)1.63822832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.81371283
2TTN4.48725743
3PDGFRA3.75865058
4OBSCN3.63303695
5DDR23.62058293
6KDR3.31780713
7SIK13.26911044
8RIPK13.25763518
9AKT33.03488101
10LATS12.64087811
11PKN22.14749040
12PHKG12.12452400
13PHKG22.12452400
14CAMK1D2.02478188
15NTRK31.98007685
16DMPK1.77804954
17MAP3K41.77318946
18TGFBR21.55798962
19DYRK31.53894241
20LATS21.53733358
21ERBB31.53031747
22TESK11.51118409
23CAMK1G1.49456791
24ERN11.47171560
25PIK3CG1.45036504
26PDK31.44893914
27PDK41.44893914
28CAMK11.44847761
29PDGFRB1.44246251
30PIK3CA1.43997616
31EPHB21.41072154
32PTK61.38849097
33LMTK21.37114901
34MARK11.35446104
35FER1.32888324
36BMPR21.32126378
37PAK21.27059825
38EPHB11.26600864
39MAPK41.21697003
40PDK21.18919812
41FGFR11.16210476
42TRPM71.12673497
43STK31.08025312
44SGK21.06719812
45EPHA31.06468541
46PNCK1.05788179
47MST1R1.05075462
48ABL21.04845029
49MAP3K91.04152248
50BMX1.01015591
51FLT31.00476350
52MTOR0.99255761
53FGFR30.99106123
54STK38L0.98155294
55PKN10.97823276
56ROCK10.93722218
57NLK0.92347233
58LRRK20.92153323
59PRKAA20.90838405
60PINK10.88480439
61PTK2B0.87072496
62EEF2K0.86925283
63STK380.86668826
64PAK30.85832369
65PTK20.85585912
66DAPK20.85486967
67MET0.84803265
68MAP2K70.84411979
69PDPK10.84171942
70FGFR40.83302006
71SGK30.81398488
72MAP2K40.80782944
73MYLK0.80333709
74SGK2230.80319875
75SGK4940.80319875
76MAPK130.76193372
77MAP3K70.75270699
78ILK0.75188195
79STK240.74283355
80PLK40.74170947
81MAPK120.73843356
82CDK60.73426255
83PRKCE0.72617850
84MOS0.72484803
85MAP2K10.72260094
86KSR20.72000688
87PAK40.68255275
88KSR10.67994483
89JAK10.67788175
90TIE10.66826922
91PRKCH0.64660561
92PRKD10.61583907
93PRKG10.60532762
94JAK20.59483723
95MAP2K30.59469336
96MAP3K100.59079694
97FGFR20.57647229
98FRK0.57314731
99RET0.56940781
100CSK0.54866822
101ROCK20.54462661
102MAP3K20.53811854
103NME10.53413751
104TNIK0.52859153
105ICK0.52739812
106MAP3K30.52660801
107PRKAA10.51180763
108CDK80.50892467
109INSRR0.50167866
110GSK3A0.49950411
111CDK120.49264281
112PRKACG0.48458376
113MAPKAPK30.47756546
114TYRO30.44652355
115BCKDK0.43994274
116NEK90.43790309
117PDK10.43156019
118SCYL20.40934257
119MAPK30.40481170
120BLK0.40446312
121MAPKAPK50.40435164
122AKT20.38638602
123MUSK0.38543860
124PRKACB0.37999351
125NEK10.37903773
126STK110.37232335
127MAP3K60.36424767
128MARK20.36300641
129IGF1R0.35731857
130CHUK0.35514320
131INSR0.35365682
132RPS6KA30.34857118
133YES10.34542136
134LIMK10.33698014
135CDK90.33301593
136WNK10.32052286
137RPS6KA20.29893477
138CDC42BPA0.27486607
139PAK60.26969770
140SRC0.25693159
141TGFBR10.25688631
142ABL10.23331128
143EPHA20.22563660
144DAPK30.21303004
145EIF2AK20.20964311
146ERBB40.20327701
147MAPK10.20266369

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.96911840
2Protein digestion and absorption_Homo sapiens_hsa049743.48075698
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.23640635
4Focal adhesion_Homo sapiens_hsa045103.05154708
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.78033757
6Dilated cardiomyopathy_Homo sapiens_hsa054142.68951110
7Phenylalanine metabolism_Homo sapiens_hsa003602.66253953
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65230864
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.48740973
10Glycerolipid metabolism_Homo sapiens_hsa005612.47093711
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.20474841
12Amoebiasis_Homo sapiens_hsa051462.04519035
13Fatty acid elongation_Homo sapiens_hsa000621.86322245
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82057300
15Proteoglycans in cancer_Homo sapiens_hsa052051.74879724
16Viral myocarditis_Homo sapiens_hsa054161.71402382
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62577157
18Small cell lung cancer_Homo sapiens_hsa052221.61726592
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.58480586
20Malaria_Homo sapiens_hsa051441.56466466
21Insulin resistance_Homo sapiens_hsa049311.51954687
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.48291127
23PPAR signaling pathway_Homo sapiens_hsa033201.47865707
24Adherens junction_Homo sapiens_hsa045201.46273318
25Tyrosine metabolism_Homo sapiens_hsa003501.42846579
26Fatty acid biosynthesis_Homo sapiens_hsa000611.42677047
27Propanoate metabolism_Homo sapiens_hsa006401.41012826
28TGF-beta signaling pathway_Homo sapiens_hsa043501.38834210
29Basal cell carcinoma_Homo sapiens_hsa052171.36694154
30AMPK signaling pathway_Homo sapiens_hsa041521.30800235
31Fatty acid metabolism_Homo sapiens_hsa012121.28942490
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26541167
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.26456842
34Fatty acid degradation_Homo sapiens_hsa000711.19942951
35Insulin signaling pathway_Homo sapiens_hsa049101.17100013
36Prion diseases_Homo sapiens_hsa050201.16592154
37MicroRNAs in cancer_Homo sapiens_hsa052061.10771501
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10649801
39beta-Alanine metabolism_Homo sapiens_hsa004101.10451486
40Nicotine addiction_Homo sapiens_hsa050331.09329973
41Hedgehog signaling pathway_Homo sapiens_hsa043401.08411788
42Hippo signaling pathway_Homo sapiens_hsa043901.04948937
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04608002
44Toxoplasmosis_Homo sapiens_hsa051451.03889468
45Prolactin signaling pathway_Homo sapiens_hsa049171.03715898
46Glucagon signaling pathway_Homo sapiens_hsa049221.03167418
47Folate biosynthesis_Homo sapiens_hsa007901.02455620
48Histidine metabolism_Homo sapiens_hsa003401.02364084
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02211534
50Tight junction_Homo sapiens_hsa045301.00616766
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98582500
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98491767
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97050727
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.96198871
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94894378
56Bladder cancer_Homo sapiens_hsa052190.92509818
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92044085
58Tryptophan metabolism_Homo sapiens_hsa003800.90356783
59Lysine degradation_Homo sapiens_hsa003100.90279603
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88725260
61Cardiac muscle contraction_Homo sapiens_hsa042600.88376273
62Platelet activation_Homo sapiens_hsa046110.87030733
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86902102
64Circadian rhythm_Homo sapiens_hsa047100.86736956
65Axon guidance_Homo sapiens_hsa043600.84083661
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.84072827
67Butanoate metabolism_Homo sapiens_hsa006500.83897325
68Chronic myeloid leukemia_Homo sapiens_hsa052200.82973438
69Melanoma_Homo sapiens_hsa052180.82346728
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81114233
71Pathways in cancer_Homo sapiens_hsa052000.79447974
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79173454
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78787042
74Ovarian steroidogenesis_Homo sapiens_hsa049130.77305330
75Starch and sucrose metabolism_Homo sapiens_hsa005000.75651728
76Type II diabetes mellitus_Homo sapiens_hsa049300.73550710
77mTOR signaling pathway_Homo sapiens_hsa041500.73268645
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.73194033
79Oxytocin signaling pathway_Homo sapiens_hsa049210.70841450
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69829688
81Prostate cancer_Homo sapiens_hsa052150.69715007
82Renin secretion_Homo sapiens_hsa049240.69141331
83Wnt signaling pathway_Homo sapiens_hsa043100.68119521
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66963250
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.66580251
86Ras signaling pathway_Homo sapiens_hsa040140.65541168
87Estrogen signaling pathway_Homo sapiens_hsa049150.64990025
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64911610
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64595815
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64517805
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64274470
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63708273
93Glioma_Homo sapiens_hsa052140.60399486
94VEGF signaling pathway_Homo sapiens_hsa043700.60325169
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.59096955
96Caffeine metabolism_Homo sapiens_hsa002320.58889879
97Pancreatic cancer_Homo sapiens_hsa052120.58878959
98FoxO signaling pathway_Homo sapiens_hsa040680.58739647
99Complement and coagulation cascades_Homo sapiens_hsa046100.55889132
100GnRH signaling pathway_Homo sapiens_hsa049120.55155402
101Sulfur relay system_Homo sapiens_hsa041220.54588208
102Synaptic vesicle cycle_Homo sapiens_hsa047210.54582035
103ABC transporters_Homo sapiens_hsa020100.54565108
104Renin-angiotensin system_Homo sapiens_hsa046140.54434728
105Dorso-ventral axis formation_Homo sapiens_hsa043200.54299874
106HIF-1 signaling pathway_Homo sapiens_hsa040660.54075997
107Melanogenesis_Homo sapiens_hsa049160.52610486
108Rap1 signaling pathway_Homo sapiens_hsa040150.51569733
109Vitamin digestion and absorption_Homo sapiens_hsa049770.51247378
110Retinol metabolism_Homo sapiens_hsa008300.50476655
111Renal cell carcinoma_Homo sapiens_hsa052110.49881477
112Notch signaling pathway_Homo sapiens_hsa043300.49050400
113Endometrial cancer_Homo sapiens_hsa052130.48858547
114Colorectal cancer_Homo sapiens_hsa052100.48764404
115MAPK signaling pathway_Homo sapiens_hsa040100.48568910
116Fat digestion and absorption_Homo sapiens_hsa049750.47961458
117TNF signaling pathway_Homo sapiens_hsa046680.47456025
118Carbon metabolism_Homo sapiens_hsa012000.47391404
119HTLV-I infection_Homo sapiens_hsa051660.47384969
120cAMP signaling pathway_Homo sapiens_hsa040240.46995771
121Osteoclast differentiation_Homo sapiens_hsa043800.45839122
122Thyroid hormone synthesis_Homo sapiens_hsa049180.44684659
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.44434015
124Cocaine addiction_Homo sapiens_hsa050300.43451510
125Sphingolipid metabolism_Homo sapiens_hsa006000.42997713
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41473621
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41404061
128Salmonella infection_Homo sapiens_hsa051320.41150592
129Glutamatergic synapse_Homo sapiens_hsa047240.40720019
130Gap junction_Homo sapiens_hsa045400.40058708
131Gastric acid secretion_Homo sapiens_hsa049710.39902433
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.39895905
133Pyruvate metabolism_Homo sapiens_hsa006200.39399713
134Acute myeloid leukemia_Homo sapiens_hsa052210.37397534
135Taste transduction_Homo sapiens_hsa047420.34775199
136Peroxisome_Homo sapiens_hsa041460.31453641
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26886440
138Sulfur metabolism_Homo sapiens_hsa009200.26633380
139Inositol phosphate metabolism_Homo sapiens_hsa005620.26234321
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25599897
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25479200
142Mineral absorption_Homo sapiens_hsa049780.24866096
143Other glycan degradation_Homo sapiens_hsa005110.24067283

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