LXN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peripheral nervous system neuron development (GO:0048935)7.89200384
2negative regulation of dendrite morphogenesis (GO:0050774)7.01247351
3endothelium development (GO:0003158)6.12989661
4regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.88057602
5sequestering of actin monomers (GO:0042989)5.74866954
6response to water (GO:0009415)5.23906741
7potassium ion export (GO:0071435)5.07691943
8positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.97425618
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.81344180
10cellular response to nicotine (GO:0071316)4.77701907
11membrane budding (GO:0006900)4.71118507
12* detection of temperature stimulus (GO:0016048)4.58952872
13definitive hemopoiesis (GO:0060216)4.45669104
14negative regulation of dendrite development (GO:2000171)4.43665136
15negative regulation of calcium ion transport into cytosol (GO:0010523)4.41729739
16response to pain (GO:0048265)4.39668953
17negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.29386884
18proteasome assembly (GO:0043248)4.28195322
19enteric nervous system development (GO:0048484)4.25715123
20negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.19763471
21blood vessel maturation (GO:0001955)4.14516626
22behavioral response to pain (GO:0048266)3.91038087
23aggressive behavior (GO:0002118)3.90038496
24protoporphyrinogen IX metabolic process (GO:0046501)3.84659854
25negative regulation of microtubule polymerization (GO:0031115)3.81527767
26protein neddylation (GO:0045116)3.79923975
27phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.78987442
28neuronal action potential (GO:0019228)3.73446847
29heme biosynthetic process (GO:0006783)3.72919740
30angiogenesis involved in wound healing (GO:0060055)3.72561807
31negative regulation of homotypic cell-cell adhesion (GO:0034111)3.69504504
32retinal ganglion cell axon guidance (GO:0031290)3.68436366
33heme metabolic process (GO:0042168)3.57878552
34adenosine metabolic process (GO:0046085)3.54591490
35protoporphyrinogen IX biosynthetic process (GO:0006782)3.54347207
36regulation of monocyte chemotaxis (GO:0090025)3.53480718
37protein maturation by protein folding (GO:0022417)3.53459884
38detection of mechanical stimulus involved in sensory perception (GO:0050974)3.51710994
39hepatocyte apoptotic process (GO:0097284)3.51569496
40chaperone-mediated protein transport (GO:0072321)3.48999931
41retina vasculature morphogenesis in camera-type eye (GO:0061299)3.48565538
42neurofilament cytoskeleton organization (GO:0060052)3.47564804
43proline transport (GO:0015824)3.40796114
44xenobiotic catabolic process (GO:0042178)3.40292593
45* detection of temperature stimulus involved in sensory perception (GO:0050961)3.36291916
46* detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.36291916
47porphyrin-containing compound metabolic process (GO:0006778)3.36259819
48regulation of amyloid precursor protein catabolic process (GO:1902991)3.34418045
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31550412
50SMAD protein complex assembly (GO:0007183)3.30408545
51glomerular filtration (GO:0003094)3.30203734
52porphyrin-containing compound biosynthetic process (GO:0006779)3.29283613
53extracellular fibril organization (GO:0043206)3.28299722
54protein heterotetramerization (GO:0051290)3.26378693
55regulation of macrophage chemotaxis (GO:0010758)3.24983207
56regulation of histone phosphorylation (GO:0033127)3.24219813
57regulation of integrin-mediated signaling pathway (GO:2001044)3.23504102
58platelet dense granule organization (GO:0060155)3.22311538
59cell migration in hindbrain (GO:0021535)3.20974495
60negative regulation of nitric oxide biosynthetic process (GO:0045019)3.19662722
61sympathetic nervous system development (GO:0048485)3.17507673
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.16796111
63synaptic vesicle maturation (GO:0016188)3.14454756
64endocrine hormone secretion (GO:0060986)3.13969869
65positive regulation of odontogenesis (GO:0042482)3.13014944
66hemoglobin metabolic process (GO:0020027)3.12753352
67urate metabolic process (GO:0046415)3.12250798
68regulation of platelet aggregation (GO:0090330)3.10817686
69neuron fate specification (GO:0048665)3.06836813
70type B pancreatic cell proliferation (GO:0044342)3.06619458
71alanine transport (GO:0032328)3.05416677
72positive regulation of vasculogenesis (GO:2001214)3.04594829
73fibril organization (GO:0097435)3.04244154
74histamine secretion (GO:0001821)3.03642354
75spermatid nucleus differentiation (GO:0007289)3.02367598
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.01720927
77adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01412779
78positive regulation of smooth muscle cell migration (GO:0014911)2.97531458
79sensory perception of pain (GO:0019233)2.97448939
80negative regulation of leukocyte chemotaxis (GO:0002689)2.95713325
81mitochondrial calcium ion homeostasis (GO:0051560)2.94767445
82tetrapyrrole biosynthetic process (GO:0033014)2.94048169
83keratan sulfate catabolic process (GO:0042340)2.93082668
84renal filtration (GO:0097205)2.92876337
85negative regulation of cation channel activity (GO:2001258)2.90295134
86positive regulation of steroid hormone secretion (GO:2000833)2.90147082
87pentose-phosphate shunt (GO:0006098)2.88988666
88cellular response to arsenic-containing substance (GO:0071243)2.87948628
89mitochondrial calcium ion transport (GO:0006851)2.86676318
90erythrocyte maturation (GO:0043249)2.85743471
91positive regulation of monocyte chemotaxis (GO:0090026)2.85471592
92negative regulation of protein polymerization (GO:0032272)2.84430756
93iron ion import (GO:0097286)2.83735114
94negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.83372895
95calcium-mediated signaling using intracellular calcium source (GO:0035584)2.77235096
96membrane assembly (GO:0071709)2.76079051
97phospholipid scrambling (GO:0017121)2.75915963
98vesicle fusion (GO:0006906)2.73006988
99negative regulation of heart rate (GO:0010459)2.72658818
100membrane depolarization during action potential (GO:0086010)2.70762434
101negative regulation of actin filament polymerization (GO:0030837)2.70180330
102diterpenoid biosynthetic process (GO:0016102)2.69856170
103bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69592312
104membrane raft organization (GO:0031579)2.68908660
105NADPH regeneration (GO:0006740)2.67672574
106sequestering of extracellular ligand from receptor (GO:0035581)2.67163110
107neuronal action potential propagation (GO:0019227)2.66852093
108regulation of homotypic cell-cell adhesion (GO:0034110)2.64944270
109positive regulation of keratinocyte differentiation (GO:0045618)2.63365717
110negative regulation of thymocyte apoptotic process (GO:0070244)2.63299513
111mesenchymal-epithelial cell signaling (GO:0060638)2.61679219
112axonemal dynein complex assembly (GO:0070286)2.61074162
113behavioral response to ethanol (GO:0048149)2.60537606
114phagocytosis, engulfment (GO:0006911)2.60391623
115tetrapyrrole metabolic process (GO:0033013)2.58557699
116regulation of dopamine secretion (GO:0014059)2.57195532
117cellular response to thyroid hormone stimulus (GO:0097067)2.56774428
118phenol-containing compound catabolic process (GO:0019336)2.56744761
119regulation of metalloenzyme activity (GO:0048552)2.56476212
120negative regulation of sodium ion transport (GO:0010766)2.55652917
121peptide catabolic process (GO:0043171)2.55355138
122positive regulation of bone resorption (GO:0045780)2.55214493
123positive regulation of bone remodeling (GO:0046852)2.55214493
124hydrogen peroxide catabolic process (GO:0042744)2.54798072
1252-deoxyribonucleotide biosynthetic process (GO:0009265)2.54531361
126deoxyribose phosphate biosynthetic process (GO:0046385)2.54531361
127negative regulation of membrane potential (GO:0045837)2.54528871
128glutamate secretion (GO:0014047)2.51924669
129response to nitrosative stress (GO:0051409)2.51205981
130positive regulation of muscle hypertrophy (GO:0014742)2.50121708
131positive regulation of cardiac muscle hypertrophy (GO:0010613)2.50121708
132negative regulation of complement activation (GO:0045916)2.49821038
133endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49686238
134negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.48982894
135synaptic vesicle exocytosis (GO:0016079)2.48963998
136deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48193720
137purine nucleotide salvage (GO:0032261)2.48165124
138response to interferon-beta (GO:0035456)2.47987144
139adenosine receptor signaling pathway (GO:0001973)2.46972919
140membrane repolarization (GO:0086009)2.45960218
141eosinophil chemotaxis (GO:0048245)2.45314934
142heme transport (GO:0015886)2.45232055
143dermatan sulfate biosynthetic process (GO:0030208)2.44462622
144negative regulation of adherens junction organization (GO:1903392)2.43647268
145negative regulation of focal adhesion assembly (GO:0051895)2.43647268
146negative regulation of cell junction assembly (GO:1901889)2.43647268
147deoxyribonucleotide catabolic process (GO:0009264)2.43584623
148positive regulation of B cell differentiation (GO:0045579)2.42310586
149regulation of vasculogenesis (GO:2001212)2.41791971
150dopamine receptor signaling pathway (GO:0007212)2.41266780
151zinc ion transport (GO:0006829)2.40986540
152axon cargo transport (GO:0008088)2.40699043
153deoxyribose phosphate catabolic process (GO:0046386)2.40566025
154negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.40232572
155regulation of cell proliferation involved in kidney development (GO:1901722)2.40072255
156response to iron ion (GO:0010039)2.39943542
157opioid receptor signaling pathway (GO:0038003)2.39792556
158sprouting angiogenesis (GO:0002040)2.37908269
159positive regulation of cell junction assembly (GO:1901890)2.37611504
160positive regulation of focal adhesion assembly (GO:0051894)2.37611504
161membrane invagination (GO:0010324)2.37142754
162actin filament capping (GO:0051693)2.36861374
163regulation of cell maturation (GO:1903429)2.36286307
164vascular endothelial growth factor signaling pathway (GO:0038084)2.35829989
165anterograde synaptic vesicle transport (GO:0048490)2.34959157
166negative regulation of striated muscle cell apoptotic process (GO:0010664)2.34662964
167ribosome assembly (GO:0042255)2.33775310
168positive regulation of potassium ion transmembrane transport (GO:1901381)2.33759751
169regulation of protein heterodimerization activity (GO:0043497)2.32401105
170histamine transport (GO:0051608)2.31162770
171intestinal epithelial cell development (GO:0060576)2.31153706
172regulation of sensory perception of pain (GO:0051930)2.30984416
173regulation of sensory perception (GO:0051931)2.30984416
174endothelial cell proliferation (GO:0001935)2.30929663
175GDP-mannose metabolic process (GO:0019673)2.30270984
176positive regulation of synaptic transmission, GABAergic (GO:0032230)2.29989765
177negative regulation of humoral immune response (GO:0002921)2.29921463
178positive regulation of protein homodimerization activity (GO:0090073)2.29498970
179dermatan sulfate metabolic process (GO:0030205)2.25803586
180positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.25141027
181vasoconstriction (GO:0042310)2.24883050
182purine-containing compound salvage (GO:0043101)2.24817318
183regulation of axon regeneration (GO:0048679)2.24707282
184regulation of neuron projection regeneration (GO:0070570)2.24707282
185response to arsenic-containing substance (GO:0046685)2.23870058
186negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.23862291
187negative regulation of calcium ion transmembrane transport (GO:1903170)2.23862291
188hematopoietic stem cell proliferation (GO:0071425)2.20323821
189eosinophil migration (GO:0072677)2.20195096
190pyrimidine nucleotide catabolic process (GO:0006244)2.20188129
191negative regulation of erythrocyte differentiation (GO:0045647)2.19736938
192regulation of cellular amino acid metabolic process (GO:0006521)2.19606852
193neutrophil activation involved in immune response (GO:0002283)2.19164523
194embryonic hemopoiesis (GO:0035162)2.17999824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human3.48627889
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.37871041
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.37227877
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.80817658
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77123254
6ZNF263_19887448_ChIP-Seq_K562_Human2.62240921
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59584888
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57104275
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.46906271
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44277517
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43610176
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40094688
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.35847943
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33705305
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29207128
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29207128
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28121803
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.17928572
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16282079
20NR3C1_23031785_ChIP-Seq_PC12_Mouse2.11754944
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.11346010
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05037707
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03074347
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00779149
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99799024
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.97398476
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95592126
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93847606
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.93666896
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92300789
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87913307
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84553919
33ELK1_19687146_ChIP-ChIP_HELA_Human1.84018792
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.83853982
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83349940
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.80522391
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.76556355
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74234732
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.68496407
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68194737
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.67643558
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67255829
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67039473
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63432175
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62832910
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62320701
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61615032
48EZH2_22144423_ChIP-Seq_EOC_Human1.61158077
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60396229
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60173553
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59348181
52CJUN_26792858_Chip-Seq_BT549_Human1.57828364
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55081772
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54591587
55* SOX2_20726797_ChIP-Seq_SW620_Human1.54487288
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53515333
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52899959
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52899959
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.52847751
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51828035
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.46024237
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45893197
63TP53_18474530_ChIP-ChIP_U2OS_Human1.45590279
64GATA1_19941826_ChIP-Seq_K562_Human1.44600401
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43479994
66EGR1_19032775_ChIP-ChIP_M12_Human1.42245751
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42228301
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42167902
69* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41436916
70VDR_22108803_ChIP-Seq_LS180_Human1.40560175
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39968827
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38041805
73* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37924424
74AR_21909140_ChIP-Seq_LNCAP_Human1.37359638
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37216368
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36903932
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36615965
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36522024
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35740880
80TFEB_21752829_ChIP-Seq_HELA_Human1.33828731
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.33816128
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33342653
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32854613
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32509637
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31053771
86DCP1A_22483619_ChIP-Seq_HELA_Human1.30499617
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.30463556
88TAF15_26573619_Chip-Seq_HEK293_Human1.30320916
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30114653
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.29798085
91VDR_23849224_ChIP-Seq_CD4+_Human1.28953676
92SCL_19346495_ChIP-Seq_HPC-7_Human1.28074165
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27996406
94GATA3_24758297_ChIP-Seq_MCF-7_Human1.27014665
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26499283
96BRD4_25478319_ChIP-Seq_HGPS_Human1.25876867
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25665685
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25094589
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24422232
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23358103
101P300_19829295_ChIP-Seq_ESCs_Human1.23119465
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22062193
103* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21963945
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20841109
105JUN_21703547_ChIP-Seq_K562_Human1.20329403
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19833342
107CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18791716
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18378467
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18086519
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17657898
111GATA2_19941826_ChIP-Seq_K562_Human1.17292613
112* STAT1_20625510_ChIP-Seq_HELA_Human1.17149368
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16672687
114SPI1_23547873_ChIP-Seq_NB4_Human1.15729160
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15257968
116ELF5_23300383_ChIP-Seq_T47D_Human1.14487817
117GATA4_25053715_ChIP-Seq_YYC3_Human1.14408402
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14246734
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14131066
120CDX2_20551321_ChIP-Seq_CACO-2_Human1.13981886
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12907397
122FOXP3_21729870_ChIP-Seq_TREG_Human1.12455346
123BCAT_22108803_ChIP-Seq_LS180_Human1.11432948
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11184643
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11013728
126TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08223751
127MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08219837
128MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08119315
129SMAD4_21799915_ChIP-Seq_A2780_Human1.08047822
130ETS1_20019798_ChIP-Seq_JURKAT_Human1.06468045
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05705741
132REST_21632747_ChIP-Seq_MESCs_Mouse1.05416002
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05247017
134STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05211630
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04278331
136CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02853215
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02331992
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02012913
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01996239
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01864016
141* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.01720942
142NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00641933
143IRF8_27001747_Chip-Seq_BMDM_Mouse0.97873875
144ER_23166858_ChIP-Seq_MCF-7_Human0.97456350
145SA1_22415368_ChIP-Seq_MEFs_Mouse0.96756453
146NANOG_19829295_ChIP-Seq_ESCs_Human0.96591269
147SOX2_19829295_ChIP-Seq_ESCs_Human0.96591269
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96470574
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96470574
150MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96361576
151SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95764405
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95554972
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.95526666
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.95112094
155EOMES_21245162_ChIP-Seq_HESCs_Human0.94031991
156BP1_19119308_ChIP-ChIP_Hs578T_Human0.93617277
157ERG_21242973_ChIP-ChIP_JURKAT_Human0.93324593
158AHR_22903824_ChIP-Seq_MCF-7_Human0.92776319
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92600885
160GATA1_22025678_ChIP-Seq_K562_Human0.92114256
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92105641
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91274923
163KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88782916
164SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88734481
165TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87419065
166NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86653118
167FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85716247
168HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84886280
169SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84711393
170TCF4_22108803_ChIP-Seq_LS180_Human0.84592570
171GATA2_21666600_ChIP-Seq_HMVEC_Human0.84591287
172RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84271938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception6.26843886
2MP0002735_abnormal_chemical_nociception5.86816952
3MP0002736_abnormal_nociception_after5.58392323
4MP0004147_increased_porphyrin_level5.57261285
5MP0001986_abnormal_taste_sensitivity5.13258200
6MP0004858_abnormal_nervous_system4.78135616
7* MP0002733_abnormal_thermal_nociception3.83775957
8MP0010368_abnormal_lymphatic_system3.66837100
9MP0004270_analgesia3.58014957
10MP0006276_abnormal_autonomic_nervous3.35650608
11MP0002734_abnormal_mechanical_nocicepti3.34455081
12* MP0001970_abnormal_pain_threshold3.20090751
13MP0000372_irregular_coat_pigmentation3.01036577
14MP0001879_abnormal_lymphatic_vessel2.79968608
15MP0002751_abnormal_autonomic_nervous2.37567645
16MP0000465_gastrointestinal_hemorrhage2.35845060
17MP0003806_abnormal_nucleotide_metabolis2.31930207
18MP0005167_abnormal_blood-brain_barrier2.28469533
19MP0003279_aneurysm2.12931130
20MP0003724_increased_susceptibility_to2.10766792
21MP0003191_abnormal_cellular_cholesterol2.05229194
22MP0004272_abnormal_basement_membrane2.03246266
23MP0009379_abnormal_foot_pigmentation1.90146790
24MP0001270_distended_abdomen1.88256473
25MP0004859_abnormal_synaptic_plasticity1.82530184
26MP0002396_abnormal_hematopoietic_system1.80037015
27MP0002877_abnormal_melanocyte_morpholog1.78750342
28MP0002184_abnormal_innervation1.62257515
29MP0010386_abnormal_urinary_bladder1.56966502
30MP0001348_abnormal_lacrimal_gland1.56255144
31MP0005085_abnormal_gallbladder_physiolo1.49487804
32MP0005503_abnormal_tendon_morphology1.47239680
33MP0002638_abnormal_pupillary_reflex1.45139879
34MP0002067_abnormal_sensory_capabilities1.42119024
35MP0002127_abnormal_cardiovascular_syste1.40411319
36MP0005171_absent_coat_pigmentation1.35838121
37MP0002163_abnormal_gland_morphology1.32410611
38MP0001542_abnormal_bone_strength1.32341892
39MP0001905_abnormal_dopamine_level1.30433951
40MP0010155_abnormal_intestine_physiology1.29761211
41MP0001873_stomach_inflammation1.27529053
42MP0008875_abnormal_xenobiotic_pharmacok1.24512157
43MP0002148_abnormal_hypersensitivity_rea1.21492226
44MP0008775_abnormal_heart_ventricle1.21427360
45MP0003136_yellow_coat_color1.21128620
46MP0000249_abnormal_blood_vessel1.19987675
47MP0009697_abnormal_copulation1.17831099
48MP0008004_abnormal_stomach_pH1.16614068
49MP0002132_abnormal_respiratory_system1.16382689
50MP0003303_peritoneal_inflammation1.15596973
51MP0000490_abnormal_crypts_of1.14640319
52MP0002272_abnormal_nervous_system1.14601890
53MP0008260_abnormal_autophagy1.13574449
54MP0005058_abnormal_lysosome_morphology1.13369206
55MP0000538_abnormal_urinary_bladder1.11370811
56MP0004883_abnormal_blood_vessel1.10884591
57MP0000613_abnormal_salivary_gland1.10757374
58MP0008007_abnormal_cellular_replicative1.10411695
59MP0004782_abnormal_surfactant_physiolog1.09986218
60MP0008438_abnormal_cutaneous_collagen1.09796626
61MP0002166_altered_tumor_susceptibility1.08998823
62MP0002138_abnormal_hepatobiliary_system1.08505044
63MP0003828_pulmonary_edema1.07431696
64MP0006036_abnormal_mitochondrial_physio1.06481589
65MP0004808_abnormal_hematopoietic_stem1.06361193
66MP0004264_abnormal_extraembryonic_tissu1.04736673
67MP0004811_abnormal_neuron_physiology1.04654401
68MP0000767_abnormal_smooth_muscle1.04485637
69MP0003183_abnormal_peptide_metabolism1.04328599
70MP0002837_dystrophic_cardiac_calcinosis1.02347703
71MP0009745_abnormal_behavioral_response1.01170988
72MP0003656_abnormal_erythrocyte_physiolo0.99279861
73MP0002295_abnormal_pulmonary_circulatio0.98976096
74MP0003300_gastrointestinal_ulcer0.96273847
75MP0001958_emphysema0.96183419
76MP0003635_abnormal_synaptic_transmissio0.96152673
77MP0003633_abnormal_nervous_system0.94958771
78MP0003638_abnormal_response/metabolism_0.94840020
79MP0005636_abnormal_mineral_homeostasis0.92477006
80MP0002332_abnormal_exercise_endurance0.92123901
81MP0004084_abnormal_cardiac_muscle0.91080278
82MP0002128_abnormal_blood_circulation0.90847820
83MP0008874_decreased_physiological_sensi0.90243105
84MP0000749_muscle_degeneration0.89841314
85MP0000955_abnormal_spinal_cord0.87979556
86MP0001440_abnormal_grooming_behavior0.87556844
87MP0003786_premature_aging0.87451003
88MP0003718_maternal_effect0.87329776
89MP0005501_abnormal_skin_physiology0.87253384
90MP0001984_abnormal_olfaction0.86504276
91MP0004510_myositis0.84156514
92MP0003866_abnormal_defecation0.83658442
93MP0002064_seizures0.83431943
94MP0003634_abnormal_glial_cell0.82778888
95MP0010352_gastrointestinal_tract_polyps0.82713046
96MP0002009_preneoplasia0.82123143
97MP0000681_abnormal_thyroid_gland0.79857673
98MP0004215_abnormal_myocardial_fiber0.79798578
99MP0002006_tumorigenesis0.79410204
100MP0009840_abnormal_foam_cell0.79192627
101MP0001853_heart_inflammation0.78923879
102MP0001299_abnormal_eye_distance/0.78724643
103MP0001756_abnormal_urination0.78505411
104MP0001845_abnormal_inflammatory_respons0.78187076
105MP0005025_abnormal_response_to0.77680877
106MP0005023_abnormal_wound_healing0.76707493
107MP0001664_abnormal_digestion0.76672174
108MP0000343_altered_response_to0.75498699
109MP0008569_lethality_at_weaning0.74978529
110MP0002876_abnormal_thyroid_physiology0.74917294
111MP0001764_abnormal_homeostasis0.74735386
112MP0006082_CNS_inflammation0.74346759
113MP0005165_increased_susceptibility_to0.73790153
114MP0002160_abnormal_reproductive_system0.73257178
115MP0009643_abnormal_urine_homeostasis0.72878700
116MP0006138_congestive_heart_failure0.72645450
117MP0003329_amyloid_beta_deposits0.71903291
118MP0001881_abnormal_mammary_gland0.71890766
119MP0002572_abnormal_emotion/affect_behav0.71756078
120MP0009250_abnormal_appendicular_skeleto0.71576166
121MP0003186_abnormal_redox_activity0.70835126
122MP0001666_abnormal_nutrient_absorption0.70808769
123MP0005397_hematopoietic_system_phenotyp0.70426340
124MP0001545_abnormal_hematopoietic_system0.70426340
125MP0001243_abnormal_dermal_layer0.70183809
126MP0008469_abnormal_protein_level0.69475143
127MP0005408_hypopigmentation0.69425135
128MP0001727_abnormal_embryo_implantation0.69089930
129MP0001663_abnormal_digestive_system0.68855750
130MP0003448_altered_tumor_morphology0.68776096
131MP0005367_renal/urinary_system_phenotyp0.68753699
132MP0000516_abnormal_urinary_system0.68753699
133MP0001614_abnormal_blood_vessel0.68196155
134MP0002282_abnormal_trachea_morphology0.67651331
135MP0009333_abnormal_splenocyte_physiolog0.67341645
136MP0005365_abnormal_bile_salt0.67139832
137MP0009785_altered_susceptibility_to0.66931473
138MP0005083_abnormal_biliary_tract0.66800509
139MP0002089_abnormal_postnatal_growth/wei0.65529891
140MP0005164_abnormal_response_to0.65473954
141MP0003631_nervous_system_phenotype0.64868605
142MP0000778_abnormal_nervous_system0.64071146
143MP0010030_abnormal_orbit_morphology0.63930358
144MP0003091_abnormal_cell_migration0.63735465
145MP0002063_abnormal_learning/memory/cond0.63320091
146MP0005595_abnormal_vascular_smooth0.63085589
147MP0005197_abnormal_uvea_morphology0.62404918
148MP0009764_decreased_sensitivity_to0.62399146
149MP0001835_abnormal_antigen_presentation0.61193025
150MP0005623_abnormal_meninges_morphology0.60221727
151MP0009384_cardiac_valve_regurgitation0.59503263
152MP0010771_integument_phenotype0.59382626
153MP0000685_abnormal_immune_system0.58944609
154MP0005464_abnormal_platelet_physiology0.58600899
155MP0009278_abnormal_bone_marrow0.57746439
156MP0000534_abnormal_ureter_morphology0.56428399
157MP0002882_abnormal_neuron_morphology0.56323921
158MP0005275_abnormal_skin_tensile0.56203705
159MP0001533_abnormal_skeleton_physiology0.55489682
160MP0005000_abnormal_immune_tolerance0.55471466
161MP0003566_abnormal_cell_adhesion0.55081430
162MP0003942_abnormal_urinary_system0.54738654
163MP0000858_altered_metastatic_potential0.53133986
164MP0005084_abnormal_gallbladder_morpholo0.52690127
165MP0005390_skeleton_phenotype0.52583663
166MP0009780_abnormal_chondrocyte_physiolo0.52508704
167MP0006054_spinal_hemorrhage0.52428279
168MP0002254_reproductive_system_inflammat0.52392851
169MP0002557_abnormal_social/conspecific_i0.51035256
170MP0005508_abnormal_skeleton_morphology0.49797351

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.95771364
2Hypothermia (HP:0002045)6.16617411
3Ulnar claw (HP:0001178)4.98646945
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.69489500
5Dysautonomia (HP:0002459)4.47761302
6Myotonia (HP:0002486)4.43851693
7Abnormal autonomic nervous system physiology (HP:0012332)4.28318945
8Abnormality of pain sensation (HP:0010832)4.19686794
9Impaired pain sensation (HP:0007328)4.19686794
10Vertebral compression fractures (HP:0002953)4.08808452
11Neuroendocrine neoplasm (HP:0100634)3.89828005
12Petechiae (HP:0000967)3.86750372
13Pheochromocytoma (HP:0002666)3.77360876
14J-shaped sella turcica (HP:0002680)3.70410145
15Action tremor (HP:0002345)3.65512655
16Prolonged bleeding time (HP:0003010)3.54101630
17Abnormality of magnesium homeostasis (HP:0004921)3.36544819
18Nonimmune hydrops fetalis (HP:0001790)3.35768763
19Type I transferrin isoform profile (HP:0003642)3.34777089
20Hypercortisolism (HP:0001578)3.26007802
21Metaphyseal dysplasia (HP:0100255)3.18772577
22Orthostatic hypotension (HP:0001278)3.10620279
23Absent/shortened dynein arms (HP:0200106)3.02449466
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.02449466
25Thoracolumbar scoliosis (HP:0002944)3.00786996
26Megalencephaly (HP:0001355)2.92280632
27Autoamputation (HP:0001218)2.91465427
28Arterial tortuosity (HP:0005116)2.91156591
29Congenital, generalized hypertrichosis (HP:0004540)2.89835382
30Absent frontal sinuses (HP:0002688)2.89523652
31Segmental peripheral demyelination/remyelination (HP:0003481)2.85148439
32Paralysis (HP:0003470)2.83113454
33Hypoventilation (HP:0002791)2.82388894
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.80827296
35Abnormal respiratory epithelium morphology (HP:0012253)2.79150260
36Abnormal respiratory motile cilium morphology (HP:0005938)2.79150260
373-Methylglutaconic aciduria (HP:0003535)2.78962985
38Abnormal hemoglobin (HP:0011902)2.78907228
39Limb dystonia (HP:0002451)2.78816304
40Vascular tortuosity (HP:0004948)2.74161673
41Short nail (HP:0001799)2.73824422
42Spinal canal stenosis (HP:0003416)2.73160180
43Polycythemia (HP:0001901)2.71691341
44Irregular epiphyses (HP:0010582)2.71468638
45Distal arthrogryposis (HP:0005684)2.68737095
46Progressive cerebellar ataxia (HP:0002073)2.67446827
47Bradycardia (HP:0001662)2.66998495
48Abnormal ciliary motility (HP:0012262)2.65647964
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.63758896
50Rhinitis (HP:0012384)2.62047453
51Systemic lupus erythematosus (HP:0002725)2.61461322
52Hypomagnesemia (HP:0002917)2.60323826
53Abnormal respiratory motile cilium physiology (HP:0012261)2.60151911
54Aortic dissection (HP:0002647)2.59454254
55Insidious onset (HP:0003587)2.59155905
56Termporal pattern (HP:0011008)2.59155905
57Biconcave vertebral bodies (HP:0004586)2.54589381
58Arthropathy (HP:0003040)2.54167060
59Tetraparesis (HP:0002273)2.52877988
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52868722
61Abnormal protein N-linked glycosylation (HP:0012347)2.52868722
62Abnormal protein glycosylation (HP:0012346)2.52868722
63Abnormal glycosylation (HP:0012345)2.52868722
64Nausea (HP:0002018)2.51407735
65Abnormality of the nasal mucosa (HP:0000433)2.51083544
66Abnormality of the vocal cords (HP:0008777)2.47549575
67Protrusio acetabuli (HP:0003179)2.44919283
68Submucous cleft hard palate (HP:0000176)2.43793780
69Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.41267001
70Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.38481302
71Abnormality of the anterior horn cell (HP:0006802)2.37171160
72Degeneration of anterior horn cells (HP:0002398)2.37171160
73Conjunctival telangiectasia (HP:0000524)2.36310034
74Severe visual impairment (HP:0001141)2.35931248
75Cervical subluxation (HP:0003308)2.35817775
76Abnormality of dentin (HP:0010299)2.34932692
77Beaking of vertebral bodies (HP:0004568)2.34716787
78Abnormal hair whorl (HP:0010721)2.33503343
79Failure to thrive in infancy (HP:0001531)2.31122028
80Hematochezia (HP:0002573)2.31021530
81Thyroid carcinoma (HP:0002890)2.29422913
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.28533803
83Amniotic constriction ring (HP:0009775)2.28322496
84Abnormality of placental membranes (HP:0011409)2.28322496
85Steppage gait (HP:0003376)2.27395579
86Esophageal varix (HP:0002040)2.27077011
87Hepatocellular necrosis (HP:0001404)2.26438520
88Reduced antithrombin III activity (HP:0001976)2.25419574
89Foot dorsiflexor weakness (HP:0009027)2.24112487
90Hepatosplenomegaly (HP:0001433)2.22329503
91Keratoconus (HP:0000563)2.22026539
92Increased corneal curvature (HP:0100692)2.22026539
93Poikilocytosis (HP:0004447)2.20852695
94Abnormality of liposaccharide metabolism (HP:0010968)2.19898283
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.19898283
96Abnormality of glycolipid metabolism (HP:0010969)2.19898283
97Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18315473
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.17148238
99Osteolytic defects of the hand bones (HP:0009699)2.17148238
100Retinal dysplasia (HP:0007973)2.15363315
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.15149698
102Mitochondrial inheritance (HP:0001427)2.14929380
103Neoplasm of the peripheral nervous system (HP:0100007)2.13751749
104Abnormality of the fetal cardiovascular system (HP:0010948)2.12138283
105Abnormal umbilical cord blood vessels (HP:0011403)2.12138283
106Single umbilical artery (HP:0001195)2.12138283
107Episodic fever (HP:0001954)2.11445681
108Spondylolisthesis (HP:0003302)2.10615874
109Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.07670073
110Abnormal platelet function (HP:0011869)2.07637600
111Impaired platelet aggregation (HP:0003540)2.07637600
112Spontaneous hematomas (HP:0007420)2.06526798
113Heterochromia iridis (HP:0001100)2.05766372
114Aortic aneurysm (HP:0004942)2.05685202
115Cerebral palsy (HP:0100021)2.04885108
116Premature rupture of membranes (HP:0001788)2.04483827
117Progressive macrocephaly (HP:0004481)2.03907952
118Decreased muscle mass (HP:0003199)2.02439122
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02171116
120Acute necrotizing encephalopathy (HP:0006965)2.01861149
121Muscle stiffness (HP:0003552)2.01552702
122Abnormality of the frontal sinuses (HP:0002687)2.00521848
123Cutaneous melanoma (HP:0012056)2.00358599
124Epistaxis (HP:0000421)1.97420478
125Popliteal pterygium (HP:0009756)1.97084518
126Renal Fanconi syndrome (HP:0001994)1.96940870
127Exertional dyspnea (HP:0002875)1.96554184
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95412715
129Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95412715
130Hypokinesia (HP:0002375)1.95326854
131Abnormality of proline metabolism (HP:0010907)1.93321799
132Hydroxyprolinuria (HP:0003080)1.93321799
133Abnormal mitochondria in muscle tissue (HP:0008316)1.92567162
134Pigmentary retinal degeneration (HP:0001146)1.91352275
135Short middle phalanx of the 5th finger (HP:0004220)1.90446475
136Hyperparathyroidism (HP:0000843)1.89995059
137Down-sloping shoulders (HP:0200021)1.89362348
138Distal lower limb muscle weakness (HP:0009053)1.89360799
139Mucosal telangiectasiae (HP:0100579)1.88790408
140Micronodular cirrhosis (HP:0001413)1.88735401
141Follicular hyperkeratosis (HP:0007502)1.88434498
142Acute encephalopathy (HP:0006846)1.87984191
143Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.87492967
144Neuroblastoma (HP:0003006)1.87492967
145Primitive neuroectodermal tumor (HP:0030065)1.87492967
146Neuroblastic tumors (HP:0004376)1.87492967
147Elevated erythrocyte sedimentation rate (HP:0003565)1.87257519
148Short tibia (HP:0005736)1.86893805
149Lumbar hyperlordosis (HP:0002938)1.86737790
150Curly hair (HP:0002212)1.86237352
151Tongue fasciculations (HP:0001308)1.85761128
152Lymphangioma (HP:0100764)1.85523027
153Abnormality of the foot musculature (HP:0001436)1.84760307
154Aortic valve stenosis (HP:0001650)1.84485590
155Autoimmune hemolytic anemia (HP:0001890)1.84410118
156Supranuclear gaze palsy (HP:0000605)1.84281301
157Abnormality of iron homeostasis (HP:0011031)1.83756031
158Purpura (HP:0000979)1.83527494
159Bronchiectasis (HP:0002110)1.83421706
160Abnormality of dental color (HP:0011073)1.83008159
161Postural tremor (HP:0002174)1.82057640
162Acanthocytosis (HP:0001927)1.80578276
163Hammertoe (HP:0001765)1.80541999
164Abnormality of transition element cation homeostasis (HP:0011030)1.80116990
165Sensory axonal neuropathy (HP:0003390)1.78825027
166Focal seizures (HP:0007359)1.77387887
167Recurrent corneal erosions (HP:0000495)1.77187142
168Epiphyseal dysplasia (HP:0002656)1.75992361
169Nuclear cataract (HP:0100018)1.75861836
170Microglossia (HP:0000171)1.75776300
171Reticulocytosis (HP:0001923)1.75403016
172Aplastic anemia (HP:0001915)1.75269565
173Increased intramyocellular lipid droplets (HP:0012240)1.74799161
174Asymmetry of the thorax (HP:0001555)1.73316120
175Neonatal short-limb short stature (HP:0008921)1.72334647
176Eczematoid dermatitis (HP:0000976)1.71428894
177Atonic seizures (HP:0010819)1.71373236
178Cerebral hemorrhage (HP:0001342)1.70891751
179Wormian bones (HP:0002645)1.70097952
180Interstitial pulmonary disease (HP:0006530)1.70078343
181Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69375226
182Hypoplasia of the brainstem (HP:0002365)1.69375226
183Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.69336247
184Abnormality of femoral epiphyses (HP:0006499)1.69336247
185Abnormality of the epiphysis of the femoral head (HP:0010574)1.68348540
186Hepatic necrosis (HP:0002605)1.66479646
187Mesangial abnormality (HP:0001966)1.65680233
188Xerostomia (HP:0000217)1.62840963
189Increased CSF lactate (HP:0002490)1.62027717
190Abnormality of the femoral head (HP:0003368)1.60742536
191Disproportionate short-trunk short stature (HP:0003521)1.59984973
192Abnormality of the phalanges of the 5th finger (HP:0004213)1.55685200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK54.15011604
2NTRK14.00948984
3NME23.45165382
4LMTK23.18349246
5LIMK13.09993340
6MAP3K123.03976921
7PIM23.01320162
8MATK2.89128221
9ARAF2.86799650
10EIF2AK12.82454433
11RIPK42.67700320
12VRK22.49081564
13GRK12.40126209
14PIK3CA2.38934734
15KDR2.38589433
16EPHA32.29987741
17NUAK12.21829286
18ADRBK22.17853050
19TESK12.16575528
20SIK32.14449577
21MINK12.12189755
22KSR22.00662773
23BCKDK1.87408771
24INSRR1.79313160
25MAP3K21.76538615
26EIF2AK31.67153542
27PDK21.56836867
28BMPR1B1.49104713
29TGFBR21.42538079
30MAP2K11.39711876
31PRKG21.38789837
32CAMKK21.37044086
33ADRBK11.36458222
34MAPKAPK31.35712704
35NEK61.35417400
36CDK91.34872809
37MAPKAPK51.33687261
38VRK11.33044069
39RET1.32193600
40PAK41.30523382
41LATS21.29230233
42SCYL21.23879144
43PTK2B1.23321880
44CASK1.20593523
45MST41.19196533
46EPHA21.11005640
47PHKG11.10717894
48PHKG21.10717894
49MAPK131.09946887
50MARK31.08703039
51RPS6KB21.04918090
52MAP3K91.04873186
53FER1.02220029
54IKBKB1.01030633
55TESK20.99832458
56TGFBR10.99246330
57NME10.96961039
58LRRK20.91677117
59PLK20.90279173
60CDK80.88820066
61CDK140.88325646
62NEK90.87460810
63NTRK30.86137233
64DMPK0.85390445
65TRPM70.83517000
66CCNB10.81474281
67RPS6KA20.81169428
68PRKCE0.80302853
69ACVR1B0.79581540
70STK160.79068553
71CSF1R0.77780544
72GRK60.77358859
73MAP3K10.74531036
74DAPK30.73115147
75NEK10.71994892
76MAP4K20.71817921
77JAK30.69082362
78BLK0.68628732
79FRK0.68084451
80MYLK0.66741280
81TRIM280.65816144
82ROCK10.65122190
83SGK20.64724505
84ZAK0.64363023
85BRAF0.63013870
86DAPK20.62003422
87IRAK30.60427654
88CDK180.60012541
89ILK0.59464193
90MAP3K110.59244477
91FGFR30.58775163
92BUB10.58180076
93ZAP700.57492058
94STK390.56505711
95SYK0.56447956
96MAP2K20.55803185
97BMPR20.55716046
98MUSK0.55360469
99SGK4940.55299540
100SGK2230.55299540
101TBK10.55072897
102MAP2K30.54415870
103PBK0.54388745
104STK240.54032248
105ERBB30.52564252
106EPHB10.51522224
107TNIK0.51134677
108IRAK10.50139423
109PRKCG0.50072949
110PAK60.49654136
111PIM10.49401198
112CDK150.49350490
113PRKD30.48680496
114AKT30.48549595
115MAP2K70.47578086
116FLT30.47525491
117CDK11A0.47339522
118TYK20.47183573
119PIK3CG0.47030498
120EPHB20.46422838
121KIT0.46413914
122CAMKK10.46258838
123YES10.45929342
124ERN10.45190360
125FES0.42361411
126MAP2K60.42279687
127PRKCD0.42041681
128PLK30.39832687
129CHUK0.39127784
130MAPK40.38848232
131NLK0.38147566
132TEC0.37647690
133CDK50.37455615
134STK30.36588315
135TAF10.35845334
136PAK20.35520604
137BRSK20.35344120
138MAP2K40.34345599
139RAF10.34268143
140PTK20.34054088
141PAK10.33771175
142DAPK10.33710103
143UHMK10.33606294
144ABL20.33526728
145IKBKE0.33500806
146TIE10.33465422
147MOS0.33310388
148PAK30.32821362
149IGF1R0.32089968
150TLK10.31090596
151ABL10.26005024
152STK40.24633055
153CSNK2A10.24244545
154PRKD10.23862126
155ERBB40.22959392
156PRKCA0.22913899
157OXSR10.22661925
158BTK0.21793345
159STK100.19729618
160AURKB0.19316320

Predicted pathways (KEGG)

RankGene SetZ-score
1Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.93126096
2Proteasome_Homo sapiens_hsa030502.91222776
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.82767940
4Synaptic vesicle cycle_Homo sapiens_hsa047212.81570934
5Sulfur metabolism_Homo sapiens_hsa009202.74706817
6Oxidative phosphorylation_Homo sapiens_hsa001902.68579525
7Glutathione metabolism_Homo sapiens_hsa004802.67246678
8Parkinsons disease_Homo sapiens_hsa050122.61587004
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.54371543
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33974329
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.26697802
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.21862930
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.19356286
14Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.99551126
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.99433690
16Thyroid cancer_Homo sapiens_hsa052161.90258189
17Ribosome_Homo sapiens_hsa030101.85790783
18Fatty acid elongation_Homo sapiens_hsa000621.83050701
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82530525
20Alzheimers disease_Homo sapiens_hsa050101.82388553
21Huntingtons disease_Homo sapiens_hsa050161.78266753
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.77964278
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71894862
24Chemical carcinogenesis_Homo sapiens_hsa052041.69571928
25Collecting duct acid secretion_Homo sapiens_hsa049661.67625694
26Phagosome_Homo sapiens_hsa041451.66632482
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56200955
28Salmonella infection_Homo sapiens_hsa051321.49960046
29Pentose phosphate pathway_Homo sapiens_hsa000301.49745026
30Vibrio cholerae infection_Homo sapiens_hsa051101.48587460
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48126393
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44728274
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42913996
34Rheumatoid arthritis_Homo sapiens_hsa053231.40362867
35Cardiac muscle contraction_Homo sapiens_hsa042601.38221659
36Shigellosis_Homo sapiens_hsa051311.35894732
37Lysosome_Homo sapiens_hsa041421.31753559
38N-Glycan biosynthesis_Homo sapiens_hsa005101.26917501
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25964075
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.24066732
41Nitrogen metabolism_Homo sapiens_hsa009101.23757812
42Systemic lupus erythematosus_Homo sapiens_hsa053221.22537438
43DNA replication_Homo sapiens_hsa030301.21617814
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20362954
45Pyrimidine metabolism_Homo sapiens_hsa002401.18212673
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17982548
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14802508
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.14435421
49Mismatch repair_Homo sapiens_hsa034301.13491573
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13116441
51TGF-beta signaling pathway_Homo sapiens_hsa043501.12340945
52Nucleotide excision repair_Homo sapiens_hsa034201.10942471
53Homologous recombination_Homo sapiens_hsa034401.09494726
54Olfactory transduction_Homo sapiens_hsa047401.09267834
55Insulin secretion_Homo sapiens_hsa049111.08730804
56Tryptophan metabolism_Homo sapiens_hsa003801.08512865
57African trypanosomiasis_Homo sapiens_hsa051431.08276477
58Dopaminergic synapse_Homo sapiens_hsa047281.07131529
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.06925563
60Cholinergic synapse_Homo sapiens_hsa047251.01759217
61Base excision repair_Homo sapiens_hsa034101.01036828
62Melanoma_Homo sapiens_hsa052180.98915732
63Purine metabolism_Homo sapiens_hsa002300.98835765
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97720917
65Leishmaniasis_Homo sapiens_hsa051400.97315251
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96222857
67Arachidonic acid metabolism_Homo sapiens_hsa005900.94653264
68Peroxisome_Homo sapiens_hsa041460.92668076
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92269884
70Salivary secretion_Homo sapiens_hsa049700.92154280
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.91856632
72Retinol metabolism_Homo sapiens_hsa008300.90967022
73Serotonergic synapse_Homo sapiens_hsa047260.90184634
74Other glycan degradation_Homo sapiens_hsa005110.90041218
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88787613
76Taste transduction_Homo sapiens_hsa047420.87553274
77Pertussis_Homo sapiens_hsa051330.85748991
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85587024
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.84590736
80Complement and coagulation cascades_Homo sapiens_hsa046100.83449685
81Mineral absorption_Homo sapiens_hsa049780.83259688
82Staphylococcus aureus infection_Homo sapiens_hsa051500.82499615
83Melanogenesis_Homo sapiens_hsa049160.82021882
84Fanconi anemia pathway_Homo sapiens_hsa034600.81256390
85Sphingolipid metabolism_Homo sapiens_hsa006000.79789406
86Vitamin digestion and absorption_Homo sapiens_hsa049770.79492028
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79345500
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79215369
89Protein export_Homo sapiens_hsa030600.79145080
90Autoimmune thyroid disease_Homo sapiens_hsa053200.75918062
91Endocytosis_Homo sapiens_hsa041440.75777358
92Tuberculosis_Homo sapiens_hsa051520.75615166
93Thyroid hormone synthesis_Homo sapiens_hsa049180.75125957
94Gap junction_Homo sapiens_hsa045400.74546695
95VEGF signaling pathway_Homo sapiens_hsa043700.74355383
96Prolactin signaling pathway_Homo sapiens_hsa049170.72287490
97Glioma_Homo sapiens_hsa052140.71815011
98Circadian entrainment_Homo sapiens_hsa047130.70989490
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70988710
100Long-term depression_Homo sapiens_hsa047300.70934861
101Type I diabetes mellitus_Homo sapiens_hsa049400.70885348
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70329439
103Pancreatic secretion_Homo sapiens_hsa049720.69763154
104Viral myocarditis_Homo sapiens_hsa054160.69445805
105Glutamatergic synapse_Homo sapiens_hsa047240.68330431
106Steroid biosynthesis_Homo sapiens_hsa001000.68323540
107Protein digestion and absorption_Homo sapiens_hsa049740.65117741
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64566719
109GnRH signaling pathway_Homo sapiens_hsa049120.63973821
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63230852
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63088710
112Rap1 signaling pathway_Homo sapiens_hsa040150.62469035
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62335099
114Long-term potentiation_Homo sapiens_hsa047200.61414465
115Allograft rejection_Homo sapiens_hsa053300.61277412
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61101841
117Propanoate metabolism_Homo sapiens_hsa006400.60896433
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58337655
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58167083
120Graft-versus-host disease_Homo sapiens_hsa053320.57834220
121Malaria_Homo sapiens_hsa051440.57819060
122Hepatitis C_Homo sapiens_hsa051600.57184105
123Metabolic pathways_Homo sapiens_hsa011000.57042903
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56843266
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56777213
126Regulation of autophagy_Homo sapiens_hsa041400.56470541
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55264650
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54778169
129Fat digestion and absorption_Homo sapiens_hsa049750.54724733
130Amoebiasis_Homo sapiens_hsa051460.54532414
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54128888
132One carbon pool by folate_Homo sapiens_hsa006700.53896890
133RNA polymerase_Homo sapiens_hsa030200.53200964
134Endometrial cancer_Homo sapiens_hsa052130.52869368
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.52693750
136Fatty acid degradation_Homo sapiens_hsa000710.51755980
137Tyrosine metabolism_Homo sapiens_hsa003500.51526044
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50784974
139Apoptosis_Homo sapiens_hsa042100.50390517
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50238182
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49109301
142Platelet activation_Homo sapiens_hsa046110.48461900
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.48430619
144Morphine addiction_Homo sapiens_hsa050320.48398240
145Toxoplasmosis_Homo sapiens_hsa051450.47879110
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.47828690
147Pyruvate metabolism_Homo sapiens_hsa006200.47063414
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47034868
149Asthma_Homo sapiens_hsa053100.46953570
150Selenocompound metabolism_Homo sapiens_hsa004500.46088206
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45371493
152Hematopoietic cell lineage_Homo sapiens_hsa046400.44820146
153Galactose metabolism_Homo sapiens_hsa000520.44581882
154Dorso-ventral axis formation_Homo sapiens_hsa043200.44541617
155Folate biosynthesis_Homo sapiens_hsa007900.44463781
156Legionellosis_Homo sapiens_hsa051340.44380324
157Renin-angiotensin system_Homo sapiens_hsa046140.44209809
158Sulfur relay system_Homo sapiens_hsa041220.44161923
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44034109
160Fructose and mannose metabolism_Homo sapiens_hsa000510.43833718
161ABC transporters_Homo sapiens_hsa020100.43164601
162Calcium signaling pathway_Homo sapiens_hsa040200.43090678
163Bladder cancer_Homo sapiens_hsa052190.42144025
164Estrogen signaling pathway_Homo sapiens_hsa049150.41530018
165RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41288939
166Epstein-Barr virus infection_Homo sapiens_hsa051690.40910542
167Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40745741
168HIF-1 signaling pathway_Homo sapiens_hsa040660.39374953
169ECM-receptor interaction_Homo sapiens_hsa045120.39128963
170Acute myeloid leukemia_Homo sapiens_hsa052210.36963242

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