LY6D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.25787745
2regulation of water loss via skin (GO:0033561)8.02926400
3sphingoid metabolic process (GO:0046519)7.37829125
4keratinization (GO:0031424)7.28603053
5viral transcription (GO:0019083)6.08295963
6phosphatidylserine acyl-chain remodeling (GO:0036150)5.90205403
7ribosomal small subunit biogenesis (GO:0042274)5.81629768
8keratinocyte differentiation (GO:0030216)5.77942128
9lipoxygenase pathway (GO:0019372)5.71921725
10establishment of tissue polarity (GO:0007164)5.71628436
11establishment of planar polarity (GO:0001736)5.71628436
12keratinocyte proliferation (GO:0043616)5.60089250
13translational termination (GO:0006415)5.58678973
14sphingosine metabolic process (GO:0006670)5.57541342
15hemidesmosome assembly (GO:0031581)5.53962655
16citrulline biosynthetic process (GO:0019240)5.53915917
17multicellular organismal water homeostasis (GO:0050891)5.48776462
18hair cycle (GO:0042633)5.44576726
19molting cycle (GO:0042303)5.44576726
20diol metabolic process (GO:0034311)5.36358799
21antigen processing and presentation of endogenous antigen (GO:0019883)5.21016064
22regulation of phospholipase A2 activity (GO:0032429)5.11099837
23intermediate filament organization (GO:0045109)5.06212727
24detection of bacterium (GO:0016045)5.05139118
25long-chain fatty acid biosynthetic process (GO:0042759)5.02500180
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93465291
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.93465291
28one-carbon compound transport (GO:0019755)4.89488044
29maturation of SSU-rRNA (GO:0030490)4.88506840
30gap junction assembly (GO:0016264)4.84359289
31ectoderm development (GO:0007398)4.78686695
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.75220092
33protein targeting to ER (GO:0045047)4.67113325
34phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.66892301
35epidermal cell differentiation (GO:0009913)4.65915753
36bundle of His cell to Purkinje myocyte communication (GO:0086069)4.65148525
37cotranslational protein targeting to membrane (GO:0006613)4.64216246
38regulation of ruffle assembly (GO:1900027)4.62404116
39water homeostasis (GO:0030104)4.58305016
40phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.58205279
41establishment of protein localization to endoplasmic reticulum (GO:0072599)4.53505416
42epidermis development (GO:0008544)4.45378517
43translational elongation (GO:0006414)4.44921297
44positive regulation of epidermal cell differentiation (GO:0045606)4.35712774
45detection of other organism (GO:0098543)4.35686336
46viral life cycle (GO:0019058)4.33599814
47protein localization to endoplasmic reticulum (GO:0070972)4.30791957
48peptide cross-linking (GO:0018149)4.28571539
49B cell receptor signaling pathway (GO:0050853)4.26734577
50epithelial cell differentiation involved in prostate gland development (GO:0060742)4.26168995
51linoleic acid metabolic process (GO:0043651)4.20744004
52cellular protein complex disassembly (GO:0043624)4.17494972
53regulation of keratinocyte differentiation (GO:0045616)4.15902133
54positive regulation of B cell differentiation (GO:0045579)4.13910918
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.11206610
56phospholipid scrambling (GO:0017121)4.11203839
57positive regulation of hair cycle (GO:0042635)4.08994562
58positive regulation of hair follicle development (GO:0051798)4.08994562
59interferon-gamma secretion (GO:0072643)4.08824616
60phosphatidylserine metabolic process (GO:0006658)4.08523088
61planar cell polarity pathway involved in neural tube closure (GO:0090179)4.07381034
62hair follicle morphogenesis (GO:0031069)4.07071907
63phosphatidylcholine acyl-chain remodeling (GO:0036151)4.00082257
64skin morphogenesis (GO:0043589)3.99669049
65polarized epithelial cell differentiation (GO:0030859)3.88183144
66antibacterial humoral response (GO:0019731)3.85774584
67ribosomal small subunit assembly (GO:0000028)3.84096666
68keratinocyte development (GO:0003334)3.81669015
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.80328977
70antimicrobial humoral response (GO:0019730)3.79644459
71eyelid development in camera-type eye (GO:0061029)3.77829869
72citrulline metabolic process (GO:0000052)3.77281686
73lateral sprouting from an epithelium (GO:0060601)3.76300856
74regulation of chemokine secretion (GO:0090196)3.73546421
75epithelium development (GO:0060429)3.69323423
76negative regulation of stress fiber assembly (GO:0051497)3.58837716
77protein complex disassembly (GO:0043241)3.53837367
78regulation of B cell differentiation (GO:0045577)3.53808755
79regulation of hypersensitivity (GO:0002883)3.49533796
80positive regulation of monocyte chemotaxis (GO:0090026)3.47761311
81regulation of natural killer cell differentiation (GO:0032823)3.46572652
82regulation of keratinocyte proliferation (GO:0010837)3.46063639
83surfactant homeostasis (GO:0043129)3.41830601
84alditol phosphate metabolic process (GO:0052646)3.41450041
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.40384423
86regulation of epidermal cell differentiation (GO:0045604)3.40161121
87negative regulation of keratinocyte proliferation (GO:0010839)3.37556333
88lymph vessel development (GO:0001945)3.36103457
89translational initiation (GO:0006413)3.31997702
90protein targeting to membrane (GO:0006612)3.28644144
91epithelial cell differentiation (GO:0030855)3.25462529
92positive regulation of interleukin-8 secretion (GO:2000484)3.24742433
93macromolecular complex disassembly (GO:0032984)3.21685341
94positive regulation of epidermis development (GO:0045684)3.21318110
95regulation of epidermis development (GO:0045682)3.19281530
96sequestering of metal ion (GO:0051238)3.17586427
97primary alcohol catabolic process (GO:0034310)3.16392652
98cellular response to antibiotic (GO:0071236)3.15475032
99polyol transport (GO:0015791)3.14594327
100positive regulation of chemokine secretion (GO:0090197)3.13954839
101negative regulation of cell fate specification (GO:0009996)3.11251641
102regulation of hair follicle development (GO:0051797)3.05090901
103epithelial cell-cell adhesion (GO:0090136)3.04302930
104G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.01906969
105positive regulation of Cdc42 GTPase activity (GO:0043089)2.94779126
106ribosomal large subunit biogenesis (GO:0042273)2.93893235
107gland morphogenesis (GO:0022612)2.93251208
108negative regulation of T cell mediated immunity (GO:0002710)2.91860734
109cytoplasmic mRNA processing body assembly (GO:0033962)2.91732445
110atrioventricular valve morphogenesis (GO:0003181)2.90986396
111positive regulation of gamma-delta T cell activation (GO:0046645)2.90823408
112peptidyl-arginine modification (GO:0018195)2.88379408
113glucosamine-containing compound catabolic process (GO:1901072)2.87497342
114ventricular cardiac muscle cell action potential (GO:0086005)2.87374717
115negative regulation of interferon-gamma production (GO:0032689)2.82929427
116positive regulation of interleukin-4 production (GO:0032753)2.82578896
117intermediate filament cytoskeleton organization (GO:0045104)2.82522005
118cellular response to zinc ion (GO:0071294)2.81900844
119inflammatory response to antigenic stimulus (GO:0002437)2.81768937
120germ cell migration (GO:0008354)2.80301478
121molting cycle process (GO:0022404)2.79598318
122hair cycle process (GO:0022405)2.79598318
123intestinal epithelial cell development (GO:0060576)2.79255427
124negative regulation of kidney development (GO:0090185)2.77885960
125regulation of cell proliferation involved in kidney development (GO:1901722)2.74995097
126intermediate filament-based process (GO:0045103)2.74091586
127chemical homeostasis within a tissue (GO:0048875)2.72623764
128cell-substrate junction assembly (GO:0007044)2.71618321
129phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70999254
130T cell selection (GO:0045058)2.69207034
131regulation of T cell chemotaxis (GO:0010819)2.68680619
132positive regulation of T cell chemotaxis (GO:0010820)2.68680619
133negative regulation of cell fate commitment (GO:0010454)2.68321641
134thymic T cell selection (GO:0045061)2.66514685
135regulation of interleukin-8 secretion (GO:2000482)2.65921818
136fatty acid elongation (GO:0030497)2.65272047
137regulation of monocyte chemotaxis (GO:0090025)2.64682907
138negative regulation of interleukin-2 production (GO:0032703)2.62777872
139transepithelial transport (GO:0070633)2.62501815
140nuclear-transcribed mRNA catabolic process (GO:0000956)2.61225991
141face development (GO:0060324)2.60589050
142innate immune response in mucosa (GO:0002227)2.59720117
143positive regulation of antigen processing and presentation (GO:0002579)2.59022202
144ethanol metabolic process (GO:0006067)2.57956516
145regulation of superoxide anion generation (GO:0032928)2.56315011
146skin development (GO:0043588)2.56241937
147positive regulation of keratinocyte differentiation (GO:0045618)2.56068615
148Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55919890
149retinol metabolic process (GO:0042572)2.55534524
150regulation of Cdc42 GTPase activity (GO:0043088)2.54319467
151renal absorption (GO:0070293)2.53770883
152ceramide biosynthetic process (GO:0046513)2.49506602
153prostanoid biosynthetic process (GO:0046457)2.47928930
154prostaglandin biosynthetic process (GO:0001516)2.47928930
155regulation of establishment of planar polarity (GO:0090175)2.46038688
156regulation of axon regeneration (GO:0048679)2.44862055
157regulation of neuron projection regeneration (GO:0070570)2.44862055
158phosphatidylglycerol metabolic process (GO:0046471)2.44542182
159apical protein localization (GO:0045176)2.43700916
160flavonoid metabolic process (GO:0009812)2.42111552
161prostanoid metabolic process (GO:0006692)2.39929076
162prostaglandin metabolic process (GO:0006693)2.39929076
163negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.36209656
164regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.35316168
165cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.35147679
166desmosome organization (GO:0002934)12.4360672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.71324575
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.10825380
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.10174472
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00792055
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.77870685
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.73891057
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36584598
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.29719134
9TP63_17297297_ChIP-ChIP_HaCaT_Human14.7001855
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98489787
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98489787
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97216578
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96406011
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.95603158
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83732940
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.80197838
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.78065044
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74255079
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69918224
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.67277978
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63152308
22UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57037372
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53846477
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50059157
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43668764
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.39434132
27GATA1_22025678_ChIP-Seq_K562_Human1.38297777
28CTCF_27219007_Chip-Seq_Bcells_Human1.37510212
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.34305907
30* SMC4_20622854_ChIP-Seq_HELA_Human1.33125869
31* RUNX1_27514584_Chip-Seq_MCF-7_Human1.32170020
32SOX2_20726797_ChIP-Seq_SW620_Human1.31853109
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30363371
34MYC_22102868_ChIP-Seq_BL_Human1.28707829
35LXR_22292898_ChIP-Seq_THP-1_Human1.28466222
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27508200
37TP63_23658742_ChIP-Seq_EP156T_Human1.26894818
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26362647
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25018725
40RUNX_20019798_ChIP-Seq_JUKART_Human1.22150464
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20928883
42ZNF263_19887448_ChIP-Seq_K562_Human1.20435686
43TCF7_22412390_ChIP-Seq_EML_Mouse1.19801312
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19106679
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.17959212
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17765296
47CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17268377
48MAF_26560356_Chip-Seq_TH1_Human1.17118415
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15519823
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12917936
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11480796
52* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11113951
53* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11000794
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10503388
55MYB_26560356_Chip-Seq_TH2_Human1.10197564
56CJUN_26792858_Chip-Seq_BT549_Human1.09385663
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08335339
58E2F1_20622854_ChIP-Seq_HELA_Human1.07403077
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.05747257
60VDR_21846776_ChIP-Seq_THP-1_Human1.05649759
61TP53_18474530_ChIP-ChIP_U2OS_Human1.05046465
62* TP63_22573176_ChIP-Seq_HFKS_Human1.04486123
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.02402207
64GATA6_21074721_ChIP-Seq_CACO-2_Human1.01136768
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01133440
66CLOCK_20551151_ChIP-Seq_293T_Human1.01118577
67SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99569684
68AR_21572438_ChIP-Seq_LNCaP_Human0.99321376
69CTCF_20526341_ChIP-Seq_ESCs_Human0.99102496
70TCF4_18268006_ChIP-ChIP_LS174T_Human0.97792546
71GATA4_25053715_ChIP-Seq_YYC3_Human0.97362948
72KLF5_25053715_ChIP-Seq_YYC3_Human0.96739161
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96518191
74EGR1_19032775_ChIP-ChIP_M12_Human0.96097039
75SA1_27219007_Chip-Seq_Bcells_Human0.95626249
76P68_20966046_ChIP-Seq_HELA_Human0.95555603
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95136133
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94843227
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94255399
80GATA6_25053715_ChIP-Seq_YYC3_Human0.92400718
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91763072
82RXR_22108803_ChIP-Seq_LS180_Human0.90915605
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90422859
84* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89805234
85BCL6_27268052_Chip-Seq_Bcells_Human0.88354350
86GATA3_24758297_ChIP-Seq_MCF-7_Human0.87680127
87AHR_22903824_ChIP-Seq_MCF-7_Human0.86638574
88ERG_20517297_ChIP-Seq_VCAP_Human0.85847724
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85701951
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85458869
91UTX_26944678_Chip-Seq_JUKART_Human0.85377771
92* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85125066
93CREB1_26743006_Chip-Seq_LNCaP_Human0.84841626
94* ATF3_27146783_Chip-Seq_COLON_Human0.84734816
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83718487
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83006713
97KDM2B_26808549_Chip-Seq_K562_Human0.81678356
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80818870
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80539659
100VDR_24763502_ChIP-Seq_THP-1_Human0.80333191
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79905381
102BCOR_27268052_Chip-Seq_Bcells_Human0.79817053
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79307347
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79090456
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78910752
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78597562
107MYB_26560356_Chip-Seq_TH1_Human0.78597371
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.78405828
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77061218
110SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76704760
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.75523519
112CEBPB_22108803_ChIP-Seq_LS180_Human0.75374412
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73056963
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72942585
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71152358
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.69295964
117UBF1/2_26484160_Chip-Seq_HMECs_Human0.69175419
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.69148812
119SA1_27219007_Chip-Seq_ERYTHROID_Human0.69119016
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.68727210
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68409949
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67324564
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67051918
124* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.66886377
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66703777
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.66450131
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.66131662
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.66131662
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.65065912
130RBPJ_21746931_ChIP-Seq_IB4_Human0.64825406
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.64205131
132PHF8_20622854_ChIP-Seq_HELA_Human0.63854925
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.63260772
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.63017802
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.62993762
136KDM2B_26808549_Chip-Seq_DND41_Human0.62096659
137STAT4_19710469_ChIP-ChIP_TH1__Mouse0.61998523
138* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.61970286
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.61581503
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60727856
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.60399267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.54619714
2MP0010234_abnormal_vibrissa_follicle5.86090584
3MP0004381_abnormal_hair_follicle4.94987739
4MP0005501_abnormal_skin_physiology4.07207351
5MP0003941_abnormal_skin_development3.62306998
6MP0005275_abnormal_skin_tensile3.45049830
7MP0002060_abnormal_skin_morphology3.29321805
8MP0003453_abnormal_keratinocyte_physiol3.16649180
9MP0000579_abnormal_nail_morphology3.16588439
10MP0001216_abnormal_epidermal_layer3.12025639
11MP0002009_preneoplasia3.06026362
12MP0002254_reproductive_system_inflammat3.05449460
13MP0002098_abnormal_vibrissa_morphology3.01037070
14MP0010678_abnormal_skin_adnexa2.88551168
15MP0004947_skin_inflammation2.67830789
16MP0000383_abnormal_hair_follicle2.66859083
17MP0000377_abnormal_hair_follicle2.63585111
18MP0010771_integument_phenotype2.62276943
19MP0000647_abnormal_sebaceous_gland2.44584764
20MP0001835_abnormal_antigen_presentation2.11091654
21MP0000467_abnormal_esophagus_morphology2.05373436
22MP0004043_abnormal_pH_regulation2.03663726
23MP0005451_abnormal_body_composition2.01796165
24MP0002166_altered_tumor_susceptibility1.95788215
25MP0005377_hearing/vestibular/ear_phenot1.94774013
26MP0003878_abnormal_ear_physiology1.94774013
27MP0000427_abnormal_hair_cycle1.89744134
28MP0001790_abnormal_immune_system1.84769317
29MP0005387_immune_system_phenotype1.84769317
30MP0001800_abnormal_humoral_immune1.74536813
31MP0004885_abnormal_endolymph1.68687439
32MP0009931_abnormal_skin_appearance1.65671490
33MP0001191_abnormal_skin_condition1.63298939
34MP0001346_abnormal_lacrimal_gland1.63261477
35MP0002006_tumorigenesis1.62532196
36MP0001243_abnormal_dermal_layer1.56635465
37MP0003566_abnormal_cell_adhesion1.52545247
38MP0009379_abnormal_foot_pigmentation1.52018867
39MP0000762_abnormal_tongue_morphology1.47397767
40MP0003011_delayed_dark_adaptation1.43320710
41MP0001188_hyperpigmentation1.42532653
42MP0000685_abnormal_immune_system1.41193794
43MP0009780_abnormal_chondrocyte_physiolo1.40826764
44MP0000367_abnormal_coat/_hair1.40179075
45MP0003705_abnormal_hypodermis_morpholog1.37679584
46MP0002452_abnormal_antigen_presenting1.32263579
47MP0001851_eye_inflammation1.31525069
48MP0003763_abnormal_thymus_physiology1.20285967
49MP0005000_abnormal_immune_tolerance1.19580562
50MP0000465_gastrointestinal_hemorrhage1.19328466
51MP0004264_abnormal_extraembryonic_tissu1.15671891
52MP0000566_synostosis1.14212367
53MP0002148_abnormal_hypersensitivity_rea1.13116249
54MP0002723_abnormal_immune_serum1.10399030
55MP0002420_abnormal_adaptive_immunity1.07661786
56MP0003436_decreased_susceptibility_to1.05392245
57MP0001819_abnormal_immune_cell1.04086930
58MP0001853_heart_inflammation1.03060271
59MP0000537_abnormal_urethra_morphology1.02281837
60MP0006054_spinal_hemorrhage1.00448167
61MP0010352_gastrointestinal_tract_polyps0.99615470
62MP0005075_abnormal_melanosome_morpholog0.97035267
63MP0005025_abnormal_response_to0.96212159
64MP0010030_abnormal_orbit_morphology0.95334110
65MP0005367_renal/urinary_system_phenotyp0.93517864
66MP0000516_abnormal_urinary_system0.93517864
67MP0010155_abnormal_intestine_physiology0.89397669
68MP0003191_abnormal_cellular_cholesterol0.89315793
69MP0003300_gastrointestinal_ulcer0.86980897
70MP0001340_abnormal_eyelid_morphology0.85164791
71MP0000015_abnormal_ear_pigmentation0.83285192
72MP0003315_abnormal_perineum_morphology0.83101281
73MP0004185_abnormal_adipocyte_glucose0.81418429
74MP0005671_abnormal_response_to0.80817338
75MP0005023_abnormal_wound_healing0.79384072
76MP0001873_stomach_inflammation0.78189460
77MP0002398_abnormal_bone_marrow0.77235900
78MP0005076_abnormal_cell_differentiation0.77145362
79MP0008789_abnormal_olfactory_epithelium0.75804580
80MP0009785_altered_susceptibility_to0.74735816
81MP0000716_abnormal_immune_system0.74229065
82MP0003136_yellow_coat_color0.71522209
83MP0001845_abnormal_inflammatory_respons0.70908913
84MP0002722_abnormal_immune_system0.70382901
85MP0003303_peritoneal_inflammation0.69864442
86MP0010386_abnormal_urinary_bladder0.67516453
87MP0000689_abnormal_spleen_morphology0.65884040
88MP0000627_abnormal_mammary_gland0.65728203
89MP0005174_abnormal_tail_pigmentation0.65675425
90MP0005409_darkened_coat_color0.65459594
91MP0002177_abnormal_outer_ear0.64195224
92MP0004782_abnormal_surfactant_physiolog0.61119118
93MP0003638_abnormal_response/metabolism_0.59880581
94MP0002234_abnormal_pharynx_morphology0.59796726
95MP0002419_abnormal_innate_immunity0.59321105
96MP0005394_taste/olfaction_phenotype0.58256756
97MP0005499_abnormal_olfactory_system0.58256756
98MP0009053_abnormal_anal_canal0.56076155
99MP0002095_abnormal_skin_pigmentation0.54741263
100MP0000703_abnormal_thymus_morphology0.54074411
101MP0002429_abnormal_blood_cell0.53204957
102MP0001879_abnormal_lymphatic_vessel0.52915723
103MP0004019_abnormal_vitamin_homeostasis0.52450142
104MP0002111_abnormal_tail_morphology0.51525586
105MP0003828_pulmonary_edema0.50824059
106MP0005503_abnormal_tendon_morphology0.50517566
107MP0001784_abnormal_fluid_regulation0.50022241
108MP0002282_abnormal_trachea_morphology0.49123142
109MP0000371_diluted_coat_color0.48945093
110MP0000538_abnormal_urinary_bladder0.48846154
111MP0001756_abnormal_urination0.48765231
112MP0002132_abnormal_respiratory_system0.48290389
113MP0002249_abnormal_larynx_morphology0.47949956
114MP0002877_abnormal_melanocyte_morpholog0.47496736
115MP0000678_abnormal_parathyroid_gland0.47486228
116MP0001919_abnormal_reproductive_system0.47358726
117MP0002136_abnormal_kidney_physiology0.45100528
118MP0001958_emphysema0.44596424
119MP0002405_respiratory_system_inflammati0.44251188
120MP0005666_abnormal_adipose_tissue0.43041870
121MP0005464_abnormal_platelet_physiology0.42519115
122MP0001186_pigmentation_phenotype0.42408609
123MP0009764_decreased_sensitivity_to0.42398313
124MP0001849_ear_inflammation0.41870172
125MP0000470_abnormal_stomach_morphology0.38239157
126MP0002089_abnormal_postnatal_growth/wei0.37871625
127MP0008875_abnormal_xenobiotic_pharmacok0.34976584
128MP0002075_abnormal_coat/hair_pigmentati0.33793793
129MP0003755_abnormal_palate_morphology0.33122116
130MP0000858_altered_metastatic_potential0.32911837
131MP0001765_abnormal_ion_homeostasis0.32027526
132MP0009333_abnormal_splenocyte_physiolog0.31874905
133MP0005193_abnormal_anterior_eye0.27456969
134MP0002133_abnormal_respiratory_system0.23836793
135MP0005388_respiratory_system_phenotype0.23836793
136MP0005508_abnormal_skeleton_morphology0.19609805
137MP0000613_abnormal_salivary_gland0.19499263
138MP0002233_abnormal_nose_morphology0.18835445
139MP0008569_lethality_at_weaning0.17665962
140MP0005375_adipose_tissue_phenotype0.17062027
141MP0004197_abnormal_fetal_growth/weight/0.15829498

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)7.90229439
2Parakeratosis (HP:0001036)7.15299075
3Hypotrichosis (HP:0001006)6.47132008
4Plantar hyperkeratosis (HP:0007556)5.91475060
5Abnormality of nail color (HP:0100643)5.47238469
6Palmoplantar hyperkeratosis (HP:0000972)5.41957040
7Onycholysis (HP:0001806)5.38946122
8Agammaglobulinemia (HP:0004432)5.20134215
9Increased IgE level (HP:0003212)5.14629144
10Palmar hyperkeratosis (HP:0010765)5.06421576
11Lip pit (HP:0100267)4.85918407
12Woolly hair (HP:0002224)4.84944016
13Erythema (HP:0010783)4.59290486
14Chronic otitis media (HP:0000389)4.45680888
15Right ventricular cardiomyopathy (HP:0011663)4.38829601
16Reticulocytopenia (HP:0001896)4.25984124
17Fragile nails (HP:0001808)4.18913467
18Congenital ichthyosiform erythroderma (HP:0007431)4.18141286
19Abnormality of the salivary glands (HP:0010286)4.16667400
20Sparse scalp hair (HP:0002209)3.91259756
21Cellulitis (HP:0100658)3.76485731
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.71013103
23Milia (HP:0001056)3.68156615
24Erythroderma (HP:0001019)3.65150800
25Abnormality of the axillary hair (HP:0100134)3.61912697
26Abnormality of secondary sexual hair (HP:0009888)3.61912697
27Natal tooth (HP:0000695)3.50327929
28Absent eyelashes (HP:0000561)3.49454806
29Recurrent bronchitis (HP:0002837)3.49068951
30Verrucae (HP:0200043)3.48207556
31Papilloma (HP:0012740)3.48207556
32Abnormality of cells of the erythroid lineage (HP:0012130)3.41499234
33Dry hair (HP:0011359)3.37589513
34Nail dystrophy (HP:0008404)3.29852076
35Abnormal blistering of the skin (HP:0008066)3.25280108
36Abnormal hair laboratory examination (HP:0003328)3.21586372
37Abnormality of B cell number (HP:0010975)3.14878548
38B lymphocytopenia (HP:0010976)3.14878548
39Thick nail (HP:0001805)3.08762890
40Gastrointestinal stroma tumor (HP:0100723)3.06192219
41Acanthosis nigricans (HP:0000956)3.01573586
42Oligodontia (HP:0000677)2.98028463
43Sparse eyelashes (HP:0000653)2.92872189
44Colitis (HP:0002583)2.86450769
45Pustule (HP:0200039)2.86238980
46Absent hair (HP:0002298)2.85498017
47Pili torti (HP:0003777)2.84525344
48Abnormal number of erythroid precursors (HP:0012131)2.82791164
49Recurrent sinusitis (HP:0011108)2.80998918
50Sepsis (HP:0100806)2.75962231
51Advanced eruption of teeth (HP:0006288)2.75505504
52Hypohidrosis (HP:0000966)2.71849886
53Abnormal hemoglobin (HP:0011902)2.70258211
54Panhypogammaglobulinemia (HP:0003139)2.59391643
55Recurrent viral infections (HP:0004429)2.58160106
56Ridged nail (HP:0001807)2.57347705
57Recurrent bacterial skin infections (HP:0005406)2.51055953
58Ectropion (HP:0000656)2.48053015
59Emphysema (HP:0002097)2.44776316
60Hamartoma of the eye (HP:0010568)2.44609504
61Pallor (HP:0000980)2.42070365
62IgM deficiency (HP:0002850)2.39189172
63Popliteal pterygium (HP:0009756)2.38047699
64Skin rash (HP:0000988)2.37593894
65Skin ulcer (HP:0200042)2.36411422
66Dehydration (HP:0001944)2.35049448
67Chronic sinusitis (HP:0011109)2.34642584
68Macrocytic anemia (HP:0001972)2.34112764
69Palmoplantar keratoderma (HP:0000982)2.33261711
70Meningitis (HP:0001287)2.31204217
71Alopecia of scalp (HP:0002293)2.28286836
72Corneal erosion (HP:0200020)2.27388757
73Abnormality of the labia majora (HP:0012881)2.27108304
74Pruritus (HP:0000989)2.25607447
75Ventricular tachycardia (HP:0004756)2.25493462
76Anhidrosis (HP:0000970)2.25445115
77Conical tooth (HP:0000698)2.25187735
78Amniotic constriction ring (HP:0009775)2.22610091
79Abnormality of placental membranes (HP:0011409)2.22610091
80Inflammation of the large intestine (HP:0002037)2.21974567
81Nasolacrimal duct obstruction (HP:0000579)2.21294814
82Osteomyelitis (HP:0002754)2.19721917
83Furrowed tongue (HP:0000221)2.17651585
84Multifactorial inheritance (HP:0001426)2.16936698
85Xerostomia (HP:0000217)2.15750435
86Bronchitis (HP:0012387)2.10570558
87Abnormality of the gastric mucosa (HP:0004295)2.10323084
88Nasal polyposis (HP:0100582)2.08450936
89Gangrene (HP:0100758)2.08185579
90Selective tooth agenesis (HP:0001592)2.08113750
91Recurrent abscess formation (HP:0002722)2.07496939
92Hyporeflexia of lower limbs (HP:0002600)2.06640934
93Curly hair (HP:0002212)2.06335485
94Dry skin (HP:0000958)2.04440531
95Blepharitis (HP:0000498)2.04025856
96Follicular hyperkeratosis (HP:0007502)2.03104452
97Hyperhidrosis (HP:0000975)2.03038165
98Epidermoid cyst (HP:0200040)2.02216375
99Gastrointestinal inflammation (HP:0004386)2.01763569
100Abnormality of the dental root (HP:0006486)2.01501947
101Taurodontia (HP:0000679)2.01501947
102Abnormality of permanent molar morphology (HP:0011071)2.01501947
103Lack of skin elasticity (HP:0100679)2.00506711
104Recurrent corneal erosions (HP:0000495)1.98833805
105Brittle hair (HP:0002299)1.98473919
106Concave nail (HP:0001598)1.97368380
107Melanocytic nevus (HP:0000995)1.96963101
108Interstitial pulmonary disease (HP:0006530)1.95696001
109Hypergammaglobulinemia (HP:0010702)1.95431491
110Atrophic scars (HP:0001075)1.94353623
111Recurrent pneumonia (HP:0006532)1.93406570
112Aplasia involving bones of the upper limbs (HP:0009823)1.91610405
113Aplasia of the phalanges of the hand (HP:0009802)1.91610405
114Aplasia involving bones of the extremities (HP:0009825)1.91610405
115Hyperactive renin-angiotensin system (HP:0000841)1.90154990
116Anonychia (HP:0001798)1.88779357
117Abnormality of molar morphology (HP:0011070)1.88294115
118Abnormality of molar (HP:0011077)1.88294115
119Conjunctival hamartoma (HP:0100780)1.88190337
120Distal lower limb muscle weakness (HP:0009053)1.87693606
121Breast hypoplasia (HP:0003187)1.87283482
122Hypoplastic labia majora (HP:0000059)1.87015620
123Mediastinal lymphadenopathy (HP:0100721)1.86872741
124Premature loss of primary teeth (HP:0006323)1.84626642
125Urticaria (HP:0001025)1.82512941
126Abnormality of the right ventricle (HP:0001707)1.80635406
127Eczematoid dermatitis (HP:0000976)1.79312321
128Abnormality of the dental pulp (HP:0006479)1.77033587
129Recurrent otitis media (HP:0000403)1.76534761
130Abnormality of hair growth rate (HP:0011363)1.76370309
131Slow-growing hair (HP:0002217)1.76370309
132Neonatal death (HP:0003811)1.75725304
133Fatigable weakness (HP:0003473)1.73212981
134Abnormality of the neuromuscular junction (HP:0003398)1.73212981
135Aplasia cutis congenita (HP:0001057)1.71259717
136Autoamputation (HP:0001218)1.70443116
137Septate vagina (HP:0001153)1.70014338
138Hypoplasia of dental enamel (HP:0006297)1.69714495
139Seborrheic dermatitis (HP:0001051)1.69312015
140Abnormality of the prostate (HP:0008775)1.69150716
141Laryngomalacia (HP:0001601)1.68365365
142Split foot (HP:0001839)1.64919262
143Abnormality of the lacrimal duct (HP:0011481)1.63460267
144Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.63189822
145Abnormality of small intestinal villus morphology (HP:0011472)1.61125459
146Villous atrophy (HP:0011473)1.61125459
147Duplicated collecting system (HP:0000081)1.56086168
148Carious teeth (HP:0000670)1.54769876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.28915919
2ERN13.53419077
3MAP3K63.52634848
4TGFBR13.36147909
5MAP3K143.26011233
6MAP4K13.20128141
7MST1R3.10393718
8MAPKAPK33.03687051
9BLK2.89868799
10MAP3K32.61556324
11LRRK22.47786720
12RPS6KB22.41218631
13EPHB22.40907106
14RIPK12.35062713
15STK102.30774573
16RIPK42.15572841
17TNK22.11593016
18FER2.10782159
19TYK21.96326266
20TRPM71.93311694
21TEC1.88537031
22MAP3K101.84495982
23BTK1.81068364
24SYK1.77893917
25GRK61.76031880
26TRIB31.73429135
27FGFR11.70043932
28SIK11.69004159
29ITK1.67932853
30GRK11.64755233
31MAP3K21.61550319
32BRSK21.45732165
33TBK11.37777916
34CSF1R1.36768183
35DYRK1B1.33338235
36MAP2K61.31996473
37EEF2K1.30236240
38PTK21.29843508
39PIK3CG1.29602962
40IKBKB1.27396468
41CDK121.23775496
42PKN11.19100397
43MAP3K91.16076773
44MARK31.15020089
45SMG11.14831703
46ERBB31.14030210
47GRK51.13930240
48IKBKE1.06937671
49EPHA31.06674095
50PBK1.01516944
51MAP3K131.00424377
52FGFR40.99465787
53DDR20.97960035
54IRAK30.96921607
55TGFBR20.96729139
56LATS10.95896091
57HIPK20.93102463
58HCK0.92038314
59MAP3K120.90201017
60FLT30.89760659
61EPHA20.85364369
62FGFR20.83842012
63LYN0.82783201
64NME10.82570657
65MAPKAPK20.82552350
66MARK20.82323927
67FRK0.81640836
68PDGFRA0.81377042
69CDK80.80170871
70FGFR30.79903707
71PTK60.76501395
72BMPR20.76159164
73MAPK70.74411596
74STK240.73534713
75JAK10.73417136
76RPS6KA40.72885284
77IRAK40.72317137
78ARAF0.70930496
79MAPK120.67840945
80FGR0.67319922
81DMPK0.67257430
82LCK0.66204030
83NME20.63634017
84PIM20.63262462
85KIT0.63106511
86PRPF4B0.62889081
87BMX0.62800913
88LATS20.61165701
89CHUK0.60608121
90ILK0.59998921
91CSK0.58486193
92DYRK30.57654263
93AKT30.57596204
94MAPKAPK50.57557827
95CDC42BPA0.57263792
96MAP3K10.57261658
97SGK2230.54169920
98SGK4940.54169920
99MAPK40.53853062
100CDK60.53610535
101ABL10.53507920
102MAP3K70.53467210
103PRKD10.52855834
104IRAK10.52141296
105PRKCQ0.51361367
106CDK90.50583893
107EIF2AK30.49093342
108PIM10.48251352
109ICK0.47668254
110ABL20.47337149
111RPS6KA10.46946783
112TAOK10.46651008
113CDK30.45264820
114PDGFRB0.45008988
115JAK20.44598852
116PRKCI0.44465828
117BCR0.42797260
118MATK0.42172710
119PKN20.41904674
120MAP2K10.41590896
121MAPK150.41255125
122PAK40.40371308
123MET0.39683389
124MTOR0.39046893
125CLK10.38559865
126CDK190.38307798
127MYLK0.37624787
128CDK70.37326516
129RPS6KA60.36032578
130MAPK30.35410729
131PRKD20.35214888
132RPS6KB10.34794906
133EPHB10.34047528
134YES10.33837798
135TESK10.32290862
136ZAP700.31757159
137BRSK10.31539807
138NLK0.30996109
139MAPK110.29727025
140TTN0.27929442
141JAK30.27598785
142PRKCD0.27231500
143TLK10.27015907
144RPS6KC10.26025263
145RPS6KL10.26025263
146RPS6KA50.25910748
147SIK30.24815920
148RET0.24429991
149STK30.22248460
150PRKAA20.21699280
151KSR20.20607499
152GSK3A0.19690291
153NEK60.19633259
154IGF1R0.19365458

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.67732875
2Primary immunodeficiency_Homo sapiens_hsa053404.34175883
3B cell receptor signaling pathway_Homo sapiens_hsa046623.54935445
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.43101823
5Sphingolipid metabolism_Homo sapiens_hsa006002.83925795
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35524755
7Linoleic acid metabolism_Homo sapiens_hsa005912.17595069
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.13433495
9Antigen processing and presentation_Homo sapiens_hsa046122.10610494
10Phenylalanine metabolism_Homo sapiens_hsa003601.97444899
11Hematopoietic cell lineage_Homo sapiens_hsa046401.96516000
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91913485
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.82712285
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.82192739
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.70868220
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70573698
17Ovarian steroidogenesis_Homo sapiens_hsa049131.55601701
18Osteoclast differentiation_Homo sapiens_hsa043801.55355470
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54875368
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.54145062
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.53621807
22Histidine metabolism_Homo sapiens_hsa003401.52331831
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.48860631
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47712304
25T cell receptor signaling pathway_Homo sapiens_hsa046601.41785443
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40139893
27Ether lipid metabolism_Homo sapiens_hsa005651.33232257
28Chemical carcinogenesis_Homo sapiens_hsa052041.32637571
29Sphingolipid signaling pathway_Homo sapiens_hsa040711.31452232
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.26095612
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20864606
32Arachidonic acid metabolism_Homo sapiens_hsa005901.20781999
33Phototransduction_Homo sapiens_hsa047441.18906956
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17824841
35Basal cell carcinoma_Homo sapiens_hsa052171.16060314
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15520202
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.13681028
38Retinol metabolism_Homo sapiens_hsa008301.13349631
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13178368
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11346628
41Pertussis_Homo sapiens_hsa051331.10843179
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08781322
43Tyrosine metabolism_Homo sapiens_hsa003501.07458496
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06033311
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05393777
46Toxoplasmosis_Homo sapiens_hsa051451.03153433
47Circadian rhythm_Homo sapiens_hsa047101.01139453
48Fatty acid elongation_Homo sapiens_hsa000621.00712049
49Leishmaniasis_Homo sapiens_hsa051400.99961879
50Hepatitis C_Homo sapiens_hsa051600.99458065
51Tuberculosis_Homo sapiens_hsa051520.98063715
52Choline metabolism in cancer_Homo sapiens_hsa052310.97290133
53Adherens junction_Homo sapiens_hsa045200.95955017
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94443473
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94056362
56Platelet activation_Homo sapiens_hsa046110.91812720
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91747946
58Renin-angiotensin system_Homo sapiens_hsa046140.91482792
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.91344724
60p53 signaling pathway_Homo sapiens_hsa041150.90946222
61Acute myeloid leukemia_Homo sapiens_hsa052210.89730888
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88766315
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88116563
64MicroRNAs in cancer_Homo sapiens_hsa052060.86419793
65Proteoglycans in cancer_Homo sapiens_hsa052050.86241669
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86150674
67Staphylococcus aureus infection_Homo sapiens_hsa051500.83706481
68Glutathione metabolism_Homo sapiens_hsa004800.82279526
69VEGF signaling pathway_Homo sapiens_hsa043700.81605363
70Caffeine metabolism_Homo sapiens_hsa002320.80323548
71Bladder cancer_Homo sapiens_hsa052190.77398306
72Starch and sucrose metabolism_Homo sapiens_hsa005000.77342772
73Endocytosis_Homo sapiens_hsa041440.75600445
74Long-term depression_Homo sapiens_hsa047300.73288215
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72850579
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.71887005
77Fatty acid biosynthesis_Homo sapiens_hsa000610.71727466
78ABC transporters_Homo sapiens_hsa020100.70827146
79Apoptosis_Homo sapiens_hsa042100.69635141
80Graft-versus-host disease_Homo sapiens_hsa053320.67080344
81Melanogenesis_Homo sapiens_hsa049160.65755983
82Prostate cancer_Homo sapiens_hsa052150.64705942
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63656536
84Measles_Homo sapiens_hsa051620.63534297
85Glioma_Homo sapiens_hsa052140.63453196
86Small cell lung cancer_Homo sapiens_hsa052220.63318005
87Fructose and mannose metabolism_Homo sapiens_hsa000510.63092668
88TNF signaling pathway_Homo sapiens_hsa046680.62575946
89ECM-receptor interaction_Homo sapiens_hsa045120.61589089
90Insulin signaling pathway_Homo sapiens_hsa049100.61248403
91Galactose metabolism_Homo sapiens_hsa000520.60947125
92Herpes simplex infection_Homo sapiens_hsa051680.60937017
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.60476325
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60419793
95Pancreatic secretion_Homo sapiens_hsa049720.59423389
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58324265
97Chemokine signaling pathway_Homo sapiens_hsa040620.57483544
98Fat digestion and absorption_Homo sapiens_hsa049750.57111495
99Inositol phosphate metabolism_Homo sapiens_hsa005620.54210246
100beta-Alanine metabolism_Homo sapiens_hsa004100.53867908
101HTLV-I infection_Homo sapiens_hsa051660.52132809
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51568237
103PPAR signaling pathway_Homo sapiens_hsa033200.50887108
104Renin secretion_Homo sapiens_hsa049240.50779301
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50090317
106Influenza A_Homo sapiens_hsa051640.50003836
107Malaria_Homo sapiens_hsa051440.47576599
108Serotonergic synapse_Homo sapiens_hsa047260.47386493
109Axon guidance_Homo sapiens_hsa043600.46532555
110Dorso-ventral axis formation_Homo sapiens_hsa043200.46238689
111Shigellosis_Homo sapiens_hsa051310.45730524
112Non-small cell lung cancer_Homo sapiens_hsa052230.45453533
113Estrogen signaling pathway_Homo sapiens_hsa049150.43596674
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.42519262
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.42227130
116Thyroid cancer_Homo sapiens_hsa052160.41221400
117Hepatitis B_Homo sapiens_hsa051610.41081922
118Chronic myeloid leukemia_Homo sapiens_hsa052200.40001454
119GnRH signaling pathway_Homo sapiens_hsa049120.39787562
120Tight junction_Homo sapiens_hsa045300.39611785
121Arginine biosynthesis_Homo sapiens_hsa002200.39569659
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39459981
123Hippo signaling pathway_Homo sapiens_hsa043900.39410696
124Notch signaling pathway_Homo sapiens_hsa043300.37783237
125Pancreatic cancer_Homo sapiens_hsa052120.37764395
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37704027
127Epstein-Barr virus infection_Homo sapiens_hsa051690.37582749
128Ras signaling pathway_Homo sapiens_hsa040140.37561723
129Rap1 signaling pathway_Homo sapiens_hsa040150.37520276
130Hedgehog signaling pathway_Homo sapiens_hsa043400.35797557
131Pathways in cancer_Homo sapiens_hsa052000.34776625
132Base excision repair_Homo sapiens_hsa034100.34599988
133Pentose phosphate pathway_Homo sapiens_hsa000300.34571644
134Wnt signaling pathway_Homo sapiens_hsa043100.34288655
135Amoebiasis_Homo sapiens_hsa051460.34176329
136Legionellosis_Homo sapiens_hsa051340.33588277
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33369144
138Non-homologous end-joining_Homo sapiens_hsa034500.33276804
139Salmonella infection_Homo sapiens_hsa051320.31758568
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31738346
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31188218
142Gastric acid secretion_Homo sapiens_hsa049710.30538533
143Focal adhesion_Homo sapiens_hsa045100.30303250
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29163484
145ErbB signaling pathway_Homo sapiens_hsa040120.28686182
146Long-term potentiation_Homo sapiens_hsa047200.28124924

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