LY6E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.01435887
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.01435887
3antigen processing and presentation of endogenous antigen (GO:0019883)6.56663292
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.49874172
5antigen processing and presentation via MHC class Ib (GO:0002475)5.15365734
6positive regulation of gamma-delta T cell activation (GO:0046645)4.92239644
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.55216557
8negative regulation of viral genome replication (GO:0045071)4.42889197
9negative regulation of cell killing (GO:0031342)4.42089944
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.42089944
11cellular response to interferon-alpha (GO:0035457)4.35462833
12ribosomal small subunit assembly (GO:0000028)4.32600775
13cellular response to zinc ion (GO:0071294)4.23744305
14regulation of B cell receptor signaling pathway (GO:0050855)4.23137860
15Arp2/3 complex-mediated actin nucleation (GO:0034314)4.03702334
16response to interferon-beta (GO:0035456)4.02003873
17response to type I interferon (GO:0034340)4.01340106
18type I interferon signaling pathway (GO:0060337)3.99536486
19cellular response to type I interferon (GO:0071357)3.99536486
20leukocyte aggregation (GO:0070486)3.98168021
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97859543
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.97859543
23modulation by symbiont of host immune response (GO:0052553)3.97859543
24positive regulation by symbiont of host defense response (GO:0052509)3.97859543
25modulation by symbiont of host defense response (GO:0052031)3.97859543
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97859543
27DNA deamination (GO:0045006)3.96652896
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.92925299
29regulation of gamma-delta T cell differentiation (GO:0045586)3.92755018
30positive regulation of lamellipodium assembly (GO:0010592)3.81814497
31immunoglobulin mediated immune response (GO:0016064)3.80264498
32detection of bacterium (GO:0016045)3.79430794
33negative regulation of phagocytosis (GO:0050765)3.70781444
34B cell receptor signaling pathway (GO:0050853)3.65123481
35detection of other organism (GO:0098543)3.64499237
36regulation of gamma-delta T cell activation (GO:0046643)3.63145898
37regulation of B cell differentiation (GO:0045577)3.60048788
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.55225193
39positive regulation of B cell differentiation (GO:0045579)3.54883764
40response to peptidoglycan (GO:0032494)3.51658122
41response to interferon-alpha (GO:0035455)3.42921840
42response to protozoan (GO:0001562)3.39868865
43interferon-gamma-mediated signaling pathway (GO:0060333)3.36431975
44cellular response to interferon-beta (GO:0035458)3.36088243
45positive regulation of macrophage differentiation (GO:0045651)3.35540309
46T cell migration (GO:0072678)3.35108039
47mast cell activation (GO:0045576)3.32352573
48defense response to protozoan (GO:0042832)3.31766260
49positive thymic T cell selection (GO:0045059)3.29015571
50B cell mediated immunity (GO:0019724)3.26168071
51viral transcription (GO:0019083)3.22941670
52positive regulation of lamellipodium organization (GO:1902745)3.21766769
53cellular response to virus (GO:0098586)3.19645026
54response to interleukin-15 (GO:0070672)3.17630333
55hepatocyte apoptotic process (GO:0097284)3.16552244
56macrophage activation involved in immune response (GO:0002281)3.14697237
57regulation of type I interferon-mediated signaling pathway (GO:0060338)3.14297569
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12100171
59positive regulation of Cdc42 GTPase activity (GO:0043089)3.10227115
60regulation of respiratory burst (GO:0060263)3.08874421
61translational termination (GO:0006415)3.04516605
62response to host (GO:0075136)3.04109311
63response to host defenses (GO:0052200)3.04109311
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04109311
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03470589
66detection of external biotic stimulus (GO:0098581)3.02689265
67cellular response to interleukin-15 (GO:0071350)3.02187737
68regulation of necroptotic process (GO:0060544)3.01500781
69regulation of response to interferon-gamma (GO:0060330)3.00943354
70COPI coating of Golgi vesicle (GO:0048205)3.00454560
71Golgi transport vesicle coating (GO:0048200)3.00454560
72negative thymic T cell selection (GO:0045060)3.00041063
73sequestering of actin monomers (GO:0042989)2.99762752
74T cell homeostasis (GO:0043029)2.99574777
75regulation of T cell receptor signaling pathway (GO:0050856)2.99494894
76positive regulation of interferon-alpha production (GO:0032727)2.99294867
77response to host immune response (GO:0052572)2.98879346
78response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98879346
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96221905
80regulation of viral genome replication (GO:0045069)2.96208022
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95329744
82negative regulation of innate immune response (GO:0045824)2.94833260
83negative T cell selection (GO:0043383)2.94675860
84regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.92846384
85negative regulation of viral process (GO:0048525)2.92800018
86antigen receptor-mediated signaling pathway (GO:0050851)2.92629012
87negative regulation of leukocyte mediated immunity (GO:0002704)2.91362521
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90974718
89respiratory burst (GO:0045730)2.88637033
90actin nucleation (GO:0045010)2.84453007
91negative regulation of viral entry into host cell (GO:0046597)2.84347399
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.83839681
93regulation of interferon-alpha production (GO:0032647)2.83752561
94myeloid dendritic cell activation (GO:0001773)2.83377780
95cotranslational protein targeting to membrane (GO:0006613)2.81805073
96protein targeting to ER (GO:0045047)2.81291995
97negative regulation of lymphocyte mediated immunity (GO:0002707)2.79939124
98positive regulation of type 2 immune response (GO:0002830)2.79642751
99NIK/NF-kappaB signaling (GO:0038061)2.79533457
100neutrophil activation involved in immune response (GO:0002283)2.78121424
101regulation of interferon-beta biosynthetic process (GO:0045357)2.77533251
102negative regulation of erythrocyte differentiation (GO:0045647)2.73879414
103leukocyte cell-cell adhesion (GO:0007159)2.72468494
104regulation of T cell tolerance induction (GO:0002664)2.72293075
105defense response to virus (GO:0051607)2.71813751
106negative regulation of interleukin-12 production (GO:0032695)2.71515103
107regulation of defense response to virus by virus (GO:0050690)2.69855495
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.69610957
109positive regulation of antigen processing and presentation (GO:0002579)2.69009057
110mature B cell differentiation involved in immune response (GO:0002313)2.68681087
111negative regulation of viral release from host cell (GO:1902187)2.68340406
112regulation of type 2 immune response (GO:0002828)2.68281625
113cellular response to interferon-gamma (GO:0071346)2.68036442
114protein localization to endoplasmic reticulum (GO:0070972)2.66900273
115regulation of T cell mediated cytotoxicity (GO:0001914)2.66750412
116thymic T cell selection (GO:0045061)2.64816378
117lymphocyte homeostasis (GO:0002260)2.64357934
118establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63997918
119translational elongation (GO:0006414)2.63801593
120regulation of necrotic cell death (GO:0010939)2.62875132
121negative regulation of cytokine production involved in immune response (GO:0002719)2.62610724
122JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62209062
123regulation of natural killer cell mediated immunity (GO:0002715)2.61646834
124regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.61646834
125negative regulation of nitric oxide biosynthetic process (GO:0045019)2.60892628
126negative regulation of myeloid cell apoptotic process (GO:0033033)2.60637571
127response to interferon-gamma (GO:0034341)2.60244244
128T cell costimulation (GO:0031295)2.60172777
129lymphocyte costimulation (GO:0031294)2.59530322
130tolerance induction (GO:0002507)2.59530301
131protein localization to endosome (GO:0036010)2.59041042
132lymph node development (GO:0048535)2.58870710
133positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58203578
134definitive hemopoiesis (GO:0060216)2.57967693
135angiogenesis involved in wound healing (GO:0060055)2.57213060
136T cell receptor signaling pathway (GO:0050852)2.56423316
137interferon-gamma production (GO:0032609)2.55991688
138cellular response to exogenous dsRNA (GO:0071360)2.55042333
139negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.54786669
140detection of biotic stimulus (GO:0009595)2.54091997
141interferon-gamma secretion (GO:0072643)2.54079278
142cytidine metabolic process (GO:0046087)2.53811854
143cytidine catabolic process (GO:0006216)2.53811854
144cytidine deamination (GO:0009972)2.53811854
145lymphocyte chemotaxis (GO:0048247)2.51418497
146ribosomal small subunit biogenesis (GO:0042274)2.50012886
147Peyers patch development (GO:0048541)2.49469428
148mucosal-associated lymphoid tissue development (GO:0048537)2.49469428
149regulation of viral entry into host cell (GO:0046596)2.49465062
150cellular extravasation (GO:0045123)2.49427753
151myeloid dendritic cell differentiation (GO:0043011)2.48711387
152neutrophil activation (GO:0042119)2.47705516
153granulocyte activation (GO:0036230)2.46937870
154germinal center formation (GO:0002467)2.46874154
155detection of molecule of bacterial origin (GO:0032490)2.46681164
156barbed-end actin filament capping (GO:0051016)2.45868525
157regulation of tolerance induction (GO:0002643)2.44972627
158pinocytosis (GO:0006907)2.44261957
159mast cell activation involved in immune response (GO:0002279)2.43316689
160mast cell degranulation (GO:0043303)2.43316689
161viral life cycle (GO:0019058)2.43218066
162regulation of T-helper 2 cell differentiation (GO:0045628)2.42612399
163natural killer cell activation (GO:0030101)2.42593169
164negative regulation of defense response to virus (GO:0050687)2.41449969
165negative regulation of type 2 immune response (GO:0002829)2.40843248
166modulation by symbiont of host cellular process (GO:0044068)2.40464592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.10153493
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72591465
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60272619
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.50181370
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37125657
6E2F7_22180533_ChIP-Seq_HELA_Human3.35389277
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17626416
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02386649
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99989847
10MYC_22102868_ChIP-Seq_BL_Human2.75926056
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.68384472
12* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.62895501
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.60436250
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55496080
15SCL_19346495_ChIP-Seq_HPC-7_Human2.55351564
16VDR_21846776_ChIP-Seq_THP-1_Human2.54920933
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49963197
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44819614
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43102323
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42668999
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.33235327
22* MYB_26560356_Chip-Seq_TH2_Human2.31690086
23MAF_26560356_Chip-Seq_TH1_Human2.29059345
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.27923115
25SPI1_23547873_ChIP-Seq_NB4_Human2.22642817
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20692391
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17927977
28* IRF8_27001747_Chip-Seq_BMDM_Mouse2.17609650
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17428215
30* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15384281
31RACK7_27058665_Chip-Seq_MCF-7_Human2.09870554
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08997310
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.06370171
34MYB_26560356_Chip-Seq_TH1_Human2.05201296
35UTX_26944678_Chip-Seq_JUKART_Human1.98718757
36* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95446223
37RUNX_20019798_ChIP-Seq_JUKART_Human1.95199002
38* VDR_24763502_ChIP-Seq_THP-1_Human1.94901244
39* RUNX1_22412390_ChIP-Seq_EML_Mouse1.94370830
40GATA1_22025678_ChIP-Seq_K562_Human1.91003288
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86418789
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79746164
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79126570
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73044802
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68744678
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66041088
47ZNF263_19887448_ChIP-Seq_K562_Human1.61654540
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60959135
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.59924591
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.57080914
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54817548
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54439355
53TCF7_22412390_ChIP-Seq_EML_Mouse1.54409216
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50937099
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49100162
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46317713
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44628627
58MAF_26560356_Chip-Seq_TH2_Human1.44290193
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.40937212
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40279227
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39175993
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38731767
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38113999
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36774918
65* MYC_18555785_ChIP-Seq_MESCs_Mouse1.36616677
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36367856
67SPI1_23127762_ChIP-Seq_K562_Human1.35703845
68P68_20966046_ChIP-Seq_HELA_Human1.35388784
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34574796
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.32320971
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31070454
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.30460355
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29692324
74BCL6_27268052_Chip-Seq_Bcells_Human1.29157851
75BCOR_27268052_Chip-Seq_Bcells_Human1.26779852
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26524985
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25986386
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24304089
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.23803203
80SMC4_20622854_ChIP-Seq_HELA_Human1.23332963
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23297207
82* GATA3_27048872_Chip-Seq_THYMUS_Human1.23042177
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22651187
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21124027
85VDR_23849224_ChIP-Seq_CD4+_Human1.20768894
86* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20318513
87* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18653867
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14712898
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14142530
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12511064
91* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12398693
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12011249
93* PU_27001747_Chip-Seq_BMDM_Mouse1.11973836
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11853890
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.11680319
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11609198
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10938533
98FOXP3_21729870_ChIP-Seq_TREG_Human1.10889183
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10243348
100ATF3_27146783_Chip-Seq_COLON_Human1.09396739
101CIITA_25753668_ChIP-Seq_RAJI_Human1.09362810
102NCOR1_26117541_ChIP-Seq_K562_Human1.09158272
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08691130
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08479001
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.08144853
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07087146
107* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06312444
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05890102
109TP63_17297297_ChIP-ChIP_HaCaT_Human1.05745120
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04815599
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04415653
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.03988275
113GABP_17652178_ChIP-ChIP_JURKAT_Human1.03465186
114* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03454710
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02888573
116* KDM2B_26808549_Chip-Seq_K562_Human1.01573326
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00363164
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99578777
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99437747
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98259200
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.98060359
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98006327
123* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95883070
124* LXR_22292898_ChIP-Seq_THP-1_Human0.95533087
125JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94749403
126EST1_17652178_ChIP-ChIP_JURKAT_Human0.94734018
127* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93537955
128GATA3_26560356_Chip-Seq_TH2_Human0.93053594
129KDM2B_26808549_Chip-Seq_DND41_Human0.91957722
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91562371
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91424911
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91270391
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90338518
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.89093786
135* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88609049
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87310482
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.85169154
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.84277059
139XRN2_22483619_ChIP-Seq_HELA_Human0.84057885
140TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83859691
141ETS1_20019798_ChIP-Seq_JURKAT_Human0.81392399
142MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81095248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.38883173
2MP0000685_abnormal_immune_system3.50498627
3MP0005671_abnormal_response_to3.36394197
4MP0009785_altered_susceptibility_to3.26884392
5MP0003724_increased_susceptibility_to3.00262049
6MP0003763_abnormal_thymus_physiology2.91602575
7MP0002166_altered_tumor_susceptibility2.90408156
8MP0005387_immune_system_phenotype2.83704926
9MP0001790_abnormal_immune_system2.83704926
10MP0001800_abnormal_humoral_immune2.83010115
11MP0005025_abnormal_response_to2.72893083
12MP0002396_abnormal_hematopoietic_system2.63042526
13MP0005000_abnormal_immune_tolerance2.57464170
14MP0002452_abnormal_antigen_presenting2.54040586
15MP0003705_abnormal_hypodermis_morpholog2.49369398
16MP0002420_abnormal_adaptive_immunity2.47013782
17MP0002723_abnormal_immune_serum2.46488220
18MP0001819_abnormal_immune_cell2.44450003
19MP0003436_decreased_susceptibility_to2.42477595
20MP0002148_abnormal_hypersensitivity_rea2.35805325
21MP0008438_abnormal_cutaneous_collagen2.33799347
22MP0002398_abnormal_bone_marrow2.29788931
23MP0002006_tumorigenesis2.29550335
24MP0002419_abnormal_innate_immunity2.27262912
25MP0010155_abnormal_intestine_physiology2.17967345
26MP0000716_abnormal_immune_system2.10996736
27MP0002405_respiratory_system_inflammati2.09190977
28MP0001873_stomach_inflammation2.06320422
29MP0001853_heart_inflammation2.05500890
30MP0005464_abnormal_platelet_physiology2.02671999
31MP0005451_abnormal_body_composition1.99471298
32MP0000689_abnormal_spleen_morphology1.99320312
33MP0009333_abnormal_splenocyte_physiolog1.97588171
34MP0006082_CNS_inflammation1.94710631
35MP0002722_abnormal_immune_system1.90393840
36MP0005397_hematopoietic_system_phenotyp1.89536075
37MP0001545_abnormal_hematopoietic_system1.89536075
38MP0008260_abnormal_autophagy1.88560854
39MP0003300_gastrointestinal_ulcer1.88037198
40MP0002429_abnormal_blood_cell1.80924545
41MP0004947_skin_inflammation1.79407911
42MP0003303_peritoneal_inflammation1.77360597
43MP0009840_abnormal_foam_cell1.75616162
44MP0001845_abnormal_inflammatory_respons1.74673042
45MP0003866_abnormal_defecation1.69509314
46MP0002877_abnormal_melanocyte_morpholog1.65711225
47MP0003806_abnormal_nucleotide_metabolis1.62768609
48MP0009278_abnormal_bone_marrow1.62218527
49MP0004808_abnormal_hematopoietic_stem1.61678136
50MP0000703_abnormal_thymus_morphology1.56500921
51MP0000490_abnormal_crypts_of1.52709578
52MP0000465_gastrointestinal_hemorrhage1.52653780
53MP0001958_emphysema1.51669518
54MP0001348_abnormal_lacrimal_gland1.49394969
55MP0000858_altered_metastatic_potential1.45086705
56MP0008469_abnormal_protein_level1.41125436
57MP0006054_spinal_hemorrhage1.35876873
58MP0004858_abnormal_nervous_system1.31698723
59MP0001533_abnormal_skeleton_physiology1.31159498
60MP0002933_joint_inflammation1.30350191
61MP0004510_myositis1.26346263
62MP0003183_abnormal_peptide_metabolism1.24114480
63MP0005390_skeleton_phenotype1.23750082
64MP0003191_abnormal_cellular_cholesterol1.23341240
65MP0005310_abnormal_salivary_gland1.22594136
66MP0000343_altered_response_to1.22233359
67MP0005174_abnormal_tail_pigmentation1.20082610
68MP0001542_abnormal_bone_strength1.19266224
69MP0002796_impaired_skin_barrier1.18884603
70MP0003279_aneurysm1.18747814
71MP0009764_decreased_sensitivity_to1.18529131
72MP0005076_abnormal_cell_differentiation1.13758733
73MP0005075_abnormal_melanosome_morpholog1.13563532
74MP0001849_ear_inflammation1.12589525
75MP0002019_abnormal_tumor_incidence1.12184961
76MP0004381_abnormal_hair_follicle1.11211268
77MP0005083_abnormal_biliary_tract1.10586264
78MP0004264_abnormal_extraembryonic_tissu1.10255279
79MP0010352_gastrointestinal_tract_polyps1.06089424
80MP0003091_abnormal_cell_migration1.05725320
81MP0003448_altered_tumor_morphology1.05624559
82MP0002060_abnormal_skin_morphology1.01667126
83MP0005058_abnormal_lysosome_morphology1.01452200
84MP0002132_abnormal_respiratory_system0.97216282
85MP0003045_fibrosis0.96939900
86MP0000604_amyloidosis0.96176868
87MP0002138_abnormal_hepatobiliary_system0.95438368
88MP0005257_abnormal_intraocular_pressure0.94910927
89MP0001851_eye_inflammation0.94654517
90MP0003828_pulmonary_edema0.94524677
91MP0005023_abnormal_wound_healing0.89506360
92MP0008007_abnormal_cellular_replicative0.89426523
93MP0009763_increased_sensitivity_to0.88111706
94MP0003795_abnormal_bone_structure0.87461765
95MP0005164_abnormal_response_to0.87087489
96MP0004185_abnormal_adipocyte_glucose0.86429114
97MP0005501_abnormal_skin_physiology0.85538129
98MP0002095_abnormal_skin_pigmentation0.84634537
99MP0003329_amyloid_beta_deposits0.83361025
100MP0005503_abnormal_tendon_morphology0.82342010
101MP0000249_abnormal_blood_vessel0.82218483
102MP0001879_abnormal_lymphatic_vessel0.82102006
103MP0001243_abnormal_dermal_layer0.81713392
104MP0003172_abnormal_lysosome_physiology0.81695052
105MP0003693_abnormal_embryo_hatching0.79978042
106MP0005623_abnormal_meninges_morphology0.79383354
107MP0004883_abnormal_blood_vessel0.77145273
108MP0008874_decreased_physiological_sensi0.77095313
109MP0003186_abnormal_redox_activity0.77026584
110MP0002998_abnormal_bone_remodeling0.75933207
111MP0008057_abnormal_DNA_replication0.75832681
112MP0001663_abnormal_digestive_system0.74431006
113MP0003453_abnormal_keratinocyte_physiol0.74085213
114MP0000477_abnormal_intestine_morphology0.71121779
115MP0005166_decreased_susceptibility_to0.70409192
116MP0010094_abnormal_chromosome_stability0.69208234
117MP0010368_abnormal_lymphatic_system0.68712946
118MP0002136_abnormal_kidney_physiology0.68008556
119MP0004782_abnormal_surfactant_physiolog0.66442311
120MP0003075_altered_response_to0.66070223
121MP0003943_abnormal_hepatobiliary_system0.65999492
122MP0002009_preneoplasia0.64977891
123MP0002254_reproductive_system_inflammat0.64164604
124MP0000015_abnormal_ear_pigmentation0.62500859
125MP0001881_abnormal_mammary_gland0.62234948
126MP0010234_abnormal_vibrissa_follicle0.61813313
127MP0000609_abnormal_liver_physiology0.61674849
128MP0003077_abnormal_cell_cycle0.60284680
129MP0009379_abnormal_foot_pigmentation0.59855037
130MP0003566_abnormal_cell_adhesion0.59014342
131MP0000598_abnormal_liver_morphology0.58955175
132MP0000313_abnormal_cell_death0.58682599
133MP0002928_abnormal_bile_duct0.58054295
134MP0009643_abnormal_urine_homeostasis0.55066214
135MP0008873_increased_physiological_sensi0.54248652

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.16072174
2Recurrent bronchitis (HP:0002837)4.76302508
3Chronic otitis media (HP:0000389)4.64908743
4IgM deficiency (HP:0002850)4.58521893
5Eczematoid dermatitis (HP:0000976)4.32188154
6Recurrent abscess formation (HP:0002722)4.23072118
7Myositis (HP:0100614)4.06797912
8Agammaglobulinemia (HP:0004432)4.01940749
9Recurrent fungal infections (HP:0002841)3.88026512
10Thrombocytosis (HP:0001894)3.80696683
11Abnormality of T cell physiology (HP:0011840)3.78851919
12IgG deficiency (HP:0004315)3.64923704
13Recurrent viral infections (HP:0004429)3.62662074
14Recurrent bacterial skin infections (HP:0005406)3.62519750
15Pustule (HP:0200039)3.61887667
16Abnormality of T cells (HP:0002843)3.61778354
17Abnormality of the nasal mucosa (HP:0000433)3.61057369
18Panhypogammaglobulinemia (HP:0003139)3.52323487
19Nasal polyposis (HP:0100582)3.51429267
20Recurrent cutaneous fungal infections (HP:0011370)3.44008515
21Chronic mucocutaneous candidiasis (HP:0002728)3.44008515
22Meningitis (HP:0001287)3.36837771
23Severe combined immunodeficiency (HP:0004430)3.36263110
24Vertebral compression fractures (HP:0002953)3.30459022
25Abnormality of B cell number (HP:0010975)3.27898831
26B lymphocytopenia (HP:0010976)3.27898831
27Interstitial pulmonary disease (HP:0006530)3.26681991
28Inflammation of the large intestine (HP:0002037)3.23613187
29Cellulitis (HP:0100658)3.23022390
30Gastrointestinal inflammation (HP:0004386)3.17786253
31Thyroiditis (HP:0100646)3.13278745
32T lymphocytopenia (HP:0005403)3.12600660
33Recurrent skin infections (HP:0001581)3.11599880
34Colitis (HP:0002583)3.06840511
35Abnormality of T cell number (HP:0011839)3.06744594
36Combined immunodeficiency (HP:0005387)3.03839970
37Lymphopenia (HP:0001888)3.00295175
38Hypoplasia of the thymus (HP:0000778)2.98827760
39Premature rupture of membranes (HP:0001788)2.98227123
40Stomatitis (HP:0010280)2.96451914
41Protrusio acetabuli (HP:0003179)2.95132878
42Petechiae (HP:0000967)2.94020551
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.92585312
44Increased IgM level (HP:0003496)2.92498563
45IgA deficiency (HP:0002720)2.91559646
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.90406406
47Gastrointestinal stroma tumor (HP:0100723)2.89719026
48Mediastinal lymphadenopathy (HP:0100721)2.88468615
49Vasculitis (HP:0002633)2.87386798
50Abnormality of liposaccharide metabolism (HP:0010968)2.82354980
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.82354980
52Abnormality of glycolipid metabolism (HP:0010969)2.82354980
53Bronchitis (HP:0012387)2.77108842
54Spontaneous hematomas (HP:0007420)2.74340730
55Prolonged bleeding time (HP:0003010)2.72641783
56Chronic diarrhea (HP:0002028)2.71933637
57Chronic sinusitis (HP:0011109)2.69507428
58Orchitis (HP:0100796)2.62852875
59Recurrent sinusitis (HP:0011108)2.62789919
60Hypergammaglobulinemia (HP:0010702)2.61973451
61Vacuolated lymphocytes (HP:0001922)2.58664443
62Abnormal number of erythroid precursors (HP:0012131)2.57313837
63Abnormality of cells of the erythroid lineage (HP:0012130)2.57120615
64Chronic obstructive pulmonary disease (HP:0006510)2.56207986
65Obstructive lung disease (HP:0006536)2.56207986
66Distal lower limb muscle weakness (HP:0009053)2.53359239
67Recurrent gram-negative bacterial infections (HP:0005420)2.52544515
68Poikiloderma (HP:0001029)2.48038907
69Reticulocytopenia (HP:0001896)2.47679240
70Epistaxis (HP:0000421)2.47388563
71Cervical subluxation (HP:0003308)2.47263404
72Impaired platelet aggregation (HP:0003540)2.46690969
73Abnormal platelet function (HP:0011869)2.46690969
74Autoimmune hemolytic anemia (HP:0001890)2.44962020
75Aplastic anemia (HP:0001915)2.44536230
76Abnormality of eosinophils (HP:0001879)2.42911560
77Purpura (HP:0000979)2.42603526
78Dysostosis multiplex (HP:0000943)2.41731622
79Lymphoma (HP:0002665)2.40752497
80Urticaria (HP:0001025)2.40660605
81Gastrointestinal infarctions (HP:0005244)2.39627125
82Abnormality of macrophages (HP:0004311)2.37695566
83Osteomyelitis (HP:0002754)2.37062135
84Loss of speech (HP:0002371)2.36846617
85Emphysema (HP:0002097)2.34487344
86Autoimmune thrombocytopenia (HP:0001973)2.32839498
87Leukocytosis (HP:0001974)2.32429855
88Periodontitis (HP:0000704)2.31675794
89Skin ulcer (HP:0200042)2.29191778
90Hemoptysis (HP:0002105)2.27844100
91Gingivitis (HP:0000230)2.26488351
92Hypertensive crisis (HP:0100735)2.21311717
93Eosinophilia (HP:0001880)2.21218333
94Skin rash (HP:0000988)2.19889526
95Peritonitis (HP:0002586)2.19674154
96Granulocytopenia (HP:0001913)2.19660169
97Increased connective tissue (HP:0009025)2.19238678
98Sepsis (HP:0100806)2.18481632
99Increased cerebral lipofuscin (HP:0011813)2.17684644
100Optic neuritis (HP:0100653)2.17232191
101Retrobulbar optic neuritis (HP:0100654)2.17232191
102Verrucae (HP:0200043)2.16904926
103Papilloma (HP:0012740)2.16904926
104Abnormality of the fingertips (HP:0001211)2.13911770
105Hypoproteinemia (HP:0003075)2.12260492
106Increased serum ferritin (HP:0003281)2.12147436
107Microcytic anemia (HP:0001935)2.09709614
108Dilatation of the ascending aorta (HP:0005111)2.09591424
109Reduced antithrombin III activity (HP:0001976)2.08931345
110Recurrent pneumonia (HP:0006532)2.07022435
111Recurrent lower respiratory tract infections (HP:0002783)2.06367665
112Pulmonary infiltrates (HP:0002113)2.04981778
113Hepatosplenomegaly (HP:0001433)2.04647900
114Abnormality of the prostate (HP:0008775)2.03941205
115Encephalitis (HP:0002383)2.02175653
116Polygenic inheritance (HP:0010982)2.01719407
117Abnormality of the pericardium (HP:0001697)2.00355839
118Increased IgE level (HP:0003212)2.00018107
119Cheilitis (HP:0100825)1.99902217
120Reduced subcutaneous adipose tissue (HP:0003758)1.99872301
121Systemic lupus erythematosus (HP:0002725)1.98010547
122Amyloidosis (HP:0011034)1.97756829
123J-shaped sella turcica (HP:0002680)1.97177643
124Hematochezia (HP:0002573)1.96454436
125Neutropenia (HP:0001875)1.96118037
126Increased neuronal autofluorescent lipopigment (HP:0002074)1.94622484
127Abnormality of the distal phalanges of the toes (HP:0010182)1.94587370
128Gingival bleeding (HP:0000225)1.94334544
129Abnormality of polysaccharide metabolism (HP:0011012)1.93224384
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93224384
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93224384
132Progressive neurologic deterioration (HP:0002344)1.92385517
133Urinary glycosaminoglycan excretion (HP:0003541)1.89007958
134Mucopolysacchariduria (HP:0008155)1.89007958
135Abnormality of the peritoneum (HP:0002585)1.85768211
136Ankle contracture (HP:0006466)1.85116619
137Distal lower limb amyotrophy (HP:0008944)1.82846906
138Premature loss of primary teeth (HP:0006323)1.82577205
139Achilles tendon contracture (HP:0001771)1.82494724
140Fragile skin (HP:0001030)1.82243766
141Hypochromic anemia (HP:0001931)1.79945433
142Keratoconjunctivitis sicca (HP:0001097)1.79437244
143Upper limb amyotrophy (HP:0009129)1.78823470
144Distal upper limb amyotrophy (HP:0007149)1.78823470
145Hyperacusis (HP:0010780)1.78396022
146Rough bone trabeculation (HP:0100670)1.77801410
147Chest pain (HP:0100749)1.76648207
148Hypertriglyceridemia (HP:0002155)1.76259052
149Episodic fever (HP:0001954)1.75966591
150Biconcave vertebral bodies (HP:0004586)1.74564895
151Blue sclerae (HP:0000592)1.73989569
152Restrictive lung disease (HP:0002091)1.73224203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.55128637
2TRIB33.31568105
3KDR3.11513729
4KIT2.67362761
5ZAP702.61674971
6TXK2.61389187
7ERN12.60581883
8MAP3K122.58827187
9SMG12.58055514
10BLK2.55482893
11PRPF4B2.50476673
12IKBKE2.44504605
13TYK22.39609754
14TBK12.35789388
15JAK32.24623186
16BTK2.15132896
17NME22.05586816
18TEC2.02845222
19TGFBR21.99787069
20FGFR41.91865349
21IRAK41.85204137
22TESK21.84002270
23PIM21.80937580
24MAP3K31.70743903
25MAP3K141.70374541
26SYK1.65699505
27STK101.57442554
28CSF1R1.52296748
29TAOK21.51395557
30JAK11.50671437
31LRRK21.49004633
32EEF2K1.40036651
33ARAF1.38212988
34GRK61.36761381
35ITK1.33912449
36CSK1.32325162
37LCK1.30220450
38TGFBR11.29998071
39IRAK31.27479725
40FLT31.27316937
41LYN1.26250812
42IKBKB1.22571896
43MAP3K101.21806284
44MST41.20938522
45PRKD21.17574107
46MATK1.16188554
47MAP2K31.16003381
48MST1R1.15332261
49TAOK31.14158077
50EIF2AK31.12154415
51NLK1.07444252
52TAOK11.06652752
53RPS6KB21.06423580
54RPS6KA41.06312101
55TIE11.05559326
56PIM11.01435371
57MYLK0.99746814
58MAP3K10.96668705
59HCK0.96009220
60CLK10.95111372
61FGFR30.94423757
62STK160.90861384
63CDC42BPA0.90367153
64MAP3K110.90340229
65RIPK40.90293645
66FES0.89083635
67MAPKAPK30.86535211
68MAP3K60.85446797
69EIF2AK10.84830438
70PAK40.84138632
71SCYL20.82142357
72ICK0.81310476
73DAPK10.79656470
74PDPK10.78653040
75ACVR1B0.78223624
76TESK10.74262321
77LIMK10.72932173
78BMX0.72423134
79SIK30.71854015
80STK380.71040005
81KSR20.70455624
82MAPK110.68111458
83VRK20.67087698
84JAK20.66532205
85CDK190.66503650
86CHUK0.65594233
87PTK20.62505237
88MAP2K20.60446990
89EPHB10.59825258
90RIPK10.58730477
91TTN0.58723360
92SIK10.57483154
93MARK20.56782485
94MAPK150.56011786
95PKN20.55236179
96IRAK20.52668658
97MAP3K80.52090033
98PDGFRA0.51198556
99PDK10.51142586
100CDK60.50805695
101TNK20.50137615
102CDK40.48808222
103EPHA20.48427803
104DDR20.47846073
105VRK10.47326747
106HIPK20.47295053
107RPS6KA60.46472866
108DYRK1B0.45649305
109CDK80.45400162
110MAPK40.45371942
111TRPM70.44284424
112FGR0.43890663
113RPS6KA20.43211989
114NME10.42259903
115NEK90.41319103
116ABL10.40826302
117PAK10.40521360
118ABL20.39918048
119PRKCD0.39165552
120NTRK10.39117916
121LMTK20.38303124
122CDK120.38203740
123MAP3K130.36022310
124DAPK30.35468947
125PTK60.35465519
126ILK0.35065573
127PRKG20.34911335
128CDK70.33942539
129RPS6KC10.33856073
130RPS6KL10.33856073
131DYRK30.33686314
132MAP2K60.33478809
133TLK10.33305460
134BUB10.33150983
135MAPKAPK20.32941992
136BCKDK0.31785808
137ATR0.30254707

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.62517986
2Antigen processing and presentation_Homo sapiens_hsa046122.66757469
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.58740273
4Ribosome_Homo sapiens_hsa030102.49639163
5Leishmaniasis_Homo sapiens_hsa051402.42328002
6DNA replication_Homo sapiens_hsa030302.35882726
7Hematopoietic cell lineage_Homo sapiens_hsa046402.31426425
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.29270028
9Measles_Homo sapiens_hsa051622.28350892
10B cell receptor signaling pathway_Homo sapiens_hsa046622.25348474
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.21826828
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15890469
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12317245
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95514286
15Asthma_Homo sapiens_hsa053101.82290802
16Osteoclast differentiation_Homo sapiens_hsa043801.79276959
17Herpes simplex infection_Homo sapiens_hsa051681.74364358
18Base excision repair_Homo sapiens_hsa034101.71885098
19Mismatch repair_Homo sapiens_hsa034301.64037237
20Allograft rejection_Homo sapiens_hsa053301.62890608
21Other glycan degradation_Homo sapiens_hsa005111.61722436
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61185122
23T cell receptor signaling pathway_Homo sapiens_hsa046601.52746905
24Legionellosis_Homo sapiens_hsa051341.50673090
25Malaria_Homo sapiens_hsa051441.46741705
26Type I diabetes mellitus_Homo sapiens_hsa049401.46419651
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.46142560
28Shigellosis_Homo sapiens_hsa051311.41113106
29Viral myocarditis_Homo sapiens_hsa054161.39174546
30Pertussis_Homo sapiens_hsa051331.37047305
31Toxoplasmosis_Homo sapiens_hsa051451.36119171
32Staphylococcus aureus infection_Homo sapiens_hsa051501.34045815
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.29013456
34Influenza A_Homo sapiens_hsa051641.27385245
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23972611
36Proteasome_Homo sapiens_hsa030501.22352613
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18392402
38Caffeine metabolism_Homo sapiens_hsa002321.16721318
39Apoptosis_Homo sapiens_hsa042101.16351851
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14629981
41Bladder cancer_Homo sapiens_hsa052191.13375440
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12554177
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12147117
44Hepatitis B_Homo sapiens_hsa051611.11702309
45Graft-versus-host disease_Homo sapiens_hsa053321.11676849
46Tuberculosis_Homo sapiens_hsa051521.10348809
47Acute myeloid leukemia_Homo sapiens_hsa052211.06914523
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.06519775
49Protein export_Homo sapiens_hsa030601.05235846
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03771960
51Endocytosis_Homo sapiens_hsa041441.02468677
52Homologous recombination_Homo sapiens_hsa034401.01558424
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99187053
54Non-small cell lung cancer_Homo sapiens_hsa052230.98268847
55Salmonella infection_Homo sapiens_hsa051320.98074437
56TNF signaling pathway_Homo sapiens_hsa046680.96678841
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95849282
58Prion diseases_Homo sapiens_hsa050200.95838087
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95633419
60Non-homologous end-joining_Homo sapiens_hsa034500.95268797
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95103646
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.90649664
63Fructose and mannose metabolism_Homo sapiens_hsa000510.89472344
64Chemokine signaling pathway_Homo sapiens_hsa040620.89471807
65Pentose phosphate pathway_Homo sapiens_hsa000300.89249484
66N-Glycan biosynthesis_Homo sapiens_hsa005100.87905151
67Spliceosome_Homo sapiens_hsa030400.87468551
68Platelet activation_Homo sapiens_hsa046110.87172078
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87042304
70p53 signaling pathway_Homo sapiens_hsa041150.85413868
71Nucleotide excision repair_Homo sapiens_hsa034200.85203809
72Hepatitis C_Homo sapiens_hsa051600.82246287
73Pancreatic cancer_Homo sapiens_hsa052120.80015421
74Sulfur relay system_Homo sapiens_hsa041220.77099346
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76833109
76Amoebiasis_Homo sapiens_hsa051460.76572355
77Lysosome_Homo sapiens_hsa041420.75843286
78HTLV-I infection_Homo sapiens_hsa051660.75100997
79Epstein-Barr virus infection_Homo sapiens_hsa051690.74117400
80Pyrimidine metabolism_Homo sapiens_hsa002400.72609325
81Autoimmune thyroid disease_Homo sapiens_hsa053200.71713515
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71099495
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70887705
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70875308
85Vibrio cholerae infection_Homo sapiens_hsa051100.70463255
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68254343
87Small cell lung cancer_Homo sapiens_hsa052220.63910686
88Viral carcinogenesis_Homo sapiens_hsa052030.61285969
89Chronic myeloid leukemia_Homo sapiens_hsa052200.60865991
90African trypanosomiasis_Homo sapiens_hsa051430.57628784
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56326319
92Focal adhesion_Homo sapiens_hsa045100.54229363
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54046151
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53775213
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.53489837
96Proteoglycans in cancer_Homo sapiens_hsa052050.52737866
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.52348907
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47831167
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46289894
100Renal cell carcinoma_Homo sapiens_hsa052110.46161895
101VEGF signaling pathway_Homo sapiens_hsa043700.46012994
102Notch signaling pathway_Homo sapiens_hsa043300.44665855
103Phenylalanine metabolism_Homo sapiens_hsa003600.43906391
104RNA degradation_Homo sapiens_hsa030180.42808445
105Rheumatoid arthritis_Homo sapiens_hsa053230.42149387
106Endometrial cancer_Homo sapiens_hsa052130.42123129
107Thyroid cancer_Homo sapiens_hsa052160.40608952
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39049851
109Insulin resistance_Homo sapiens_hsa049310.37985009
110Prolactin signaling pathway_Homo sapiens_hsa049170.37211243
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.36791988
112Insulin signaling pathway_Homo sapiens_hsa049100.36412464
113Colorectal cancer_Homo sapiens_hsa052100.36122059
114Glioma_Homo sapiens_hsa052140.35307463
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33996132
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33173973
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32953445
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32341886
119Folate biosynthesis_Homo sapiens_hsa007900.32000326
120Galactose metabolism_Homo sapiens_hsa000520.31972208
121Cell cycle_Homo sapiens_hsa041100.30278103
122Renin-angiotensin system_Homo sapiens_hsa046140.28721175
123Phagosome_Homo sapiens_hsa041450.28232604
124HIF-1 signaling pathway_Homo sapiens_hsa040660.26977577
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.26354878
126RNA polymerase_Homo sapiens_hsa030200.25108096
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.22209995

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