LY6G5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.72517887
2single fertilization (GO:0007338)9.30425977
3indole-containing compound catabolic process (GO:0042436)9.02163414
4indolalkylamine catabolic process (GO:0046218)9.02163414
5tryptophan catabolic process (GO:0006569)9.02163414
6heterotypic cell-cell adhesion (GO:0034113)8.92135572
7negative regulation of interleukin-10 production (GO:0032693)7.85588090
8tryptophan metabolic process (GO:0006568)7.76146973
9positive regulation of type 2 immune response (GO:0002830)7.74760718
10fertilization (GO:0009566)6.16597051
11aromatic amino acid family catabolic process (GO:0009074)5.99544394
12amine catabolic process (GO:0009310)5.83611842
13cellular biogenic amine catabolic process (GO:0042402)5.83611842
14indolalkylamine metabolic process (GO:0006586)5.68297802
15negative regulation of interleukin-8 production (GO:0032717)5.57077679
16behavioral response to nicotine (GO:0035095)5.51587486
17benzene-containing compound metabolic process (GO:0042537)4.96546391
18digestion (GO:0007586)4.89189523
19epithelial cell morphogenesis (GO:0003382)4.79704787
20aromatic amino acid family metabolic process (GO:0009072)4.63732323
21negative regulation of endopeptidase activity (GO:0010951)4.61589117
22fucose catabolic process (GO:0019317)4.60295581
23L-fucose metabolic process (GO:0042354)4.60295581
24L-fucose catabolic process (GO:0042355)4.60295581
25positive regulation of cell-cell adhesion (GO:0022409)4.54412965
26negative regulation of T cell apoptotic process (GO:0070233)4.53629131
27negative regulation of peptidase activity (GO:0010466)4.40688670
28transepithelial transport (GO:0070633)4.28219627
29regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.17695883
30regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.17695883
31indole-containing compound metabolic process (GO:0042430)4.05419170
32N-acetylneuraminate metabolic process (GO:0006054)4.01892863
33regulation of type 2 immune response (GO:0002828)3.91960866
34regulation of clathrin-mediated endocytosis (GO:2000369)3.87223924
35defense response to bacterium (GO:0042742)3.78470867
36regulation of neurotransmitter uptake (GO:0051580)3.76056491
37platelet dense granule organization (GO:0060155)3.70371573
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.61176029
39reverse cholesterol transport (GO:0043691)3.60330890
40protein neddylation (GO:0045116)3.56728219
41sulfur amino acid catabolic process (GO:0000098)3.54007731
42reflex (GO:0060004)3.52599287
43response to pheromone (GO:0019236)3.45502900
44DNA deamination (GO:0045006)3.43603169
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43423169
46epithelial cilium movement (GO:0003351)3.41779152
47neuronal action potential (GO:0019228)3.39957741
48negative regulation of telomere maintenance (GO:0032205)3.37983301
49negative regulation of protein autophosphorylation (GO:0031953)3.37254941
50negative regulation of mast cell activation (GO:0033004)3.33255182
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30308931
52response to bacterium (GO:0009617)3.26862575
53polyamine biosynthetic process (GO:0006596)3.23931752
54regulation of macrophage activation (GO:0043030)3.18683810
55detection of light stimulus involved in sensory perception (GO:0050962)3.18187700
56detection of light stimulus involved in visual perception (GO:0050908)3.18187700
57behavioral response to cocaine (GO:0048148)3.17460390
58phospholipid homeostasis (GO:0055091)3.11209404
59sulfation (GO:0051923)3.08900093
60negative regulation of proteolysis (GO:0045861)3.08778048
61gamma-aminobutyric acid transport (GO:0015812)3.08746978
62regulation of memory T cell differentiation (GO:0043380)3.07715369
63cellular biogenic amine biosynthetic process (GO:0042401)3.07576727
64piRNA metabolic process (GO:0034587)3.06116378
65negative regulation of protein processing (GO:0010955)3.00952045
66negative regulation of protein maturation (GO:1903318)3.00952045
67seminiferous tubule development (GO:0072520)27.0012045
68negative regulation of glycogen biosynthetic process (GO:0045719)2.97984549
69ubiquinone biosynthetic process (GO:0006744)2.97707357
70synaptic transmission, dopaminergic (GO:0001963)2.96633086
71amine biosynthetic process (GO:0009309)2.96381639
72G-protein coupled receptor internalization (GO:0002031)2.95593831
73regulation of lipoprotein metabolic process (GO:0050746)2.93337362
74glial cell proliferation (GO:0014009)2.92884163
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92206166
76regulation of synaptic transmission, dopaminergic (GO:0032225)2.91750977
77columnar/cuboidal epithelial cell development (GO:0002066)2.89049334
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.88420678
79negative regulation of heart rate (GO:0010459)2.88050887
80cilium movement (GO:0003341)2.84660636
81negative regulation of lymphocyte apoptotic process (GO:0070229)2.84462012
82pyrimidine ribonucleoside catabolic process (GO:0046133)2.82783738
83positive regulation of interleukin-12 production (GO:0032735)2.81750304
84alpha-linolenic acid metabolic process (GO:0036109)2.81348803
85regulation of activated T cell proliferation (GO:0046006)2.81033976
86rhodopsin mediated signaling pathway (GO:0016056)2.80404371
87regulation of action potential (GO:0098900)2.79690985
88multicellular organism reproduction (GO:0032504)2.78479355
89positive regulation of cellular amide metabolic process (GO:0034250)2.77356087
90ubiquinone metabolic process (GO:0006743)2.77260621
91cysteine metabolic process (GO:0006534)2.76463195
92axonemal dynein complex assembly (GO:0070286)2.75702080
93synaptic transmission, cholinergic (GO:0007271)2.75380304
94cilium or flagellum-dependent cell motility (GO:0001539)2.74846687
95phosphatidylinositol acyl-chain remodeling (GO:0036149)2.73157099
96negative regulation of glycogen metabolic process (GO:0070874)2.71860672
97pyrimidine nucleobase catabolic process (GO:0006208)2.71278062
98purinergic nucleotide receptor signaling pathway (GO:0035590)2.71105508
99regulation of cilium movement (GO:0003352)2.70460507
100mitochondrial respiratory chain complex I assembly (GO:0032981)2.70264969
101NADH dehydrogenase complex assembly (GO:0010257)2.70264969
102mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70264969
103artery development (GO:0060840)2.70209983
104polyamine metabolic process (GO:0006595)2.68775456
105axoneme assembly (GO:0035082)2.67860926
106O-glycan processing (GO:0016266)2.66836325
107thrombin receptor signaling pathway (GO:0070493)2.64758589
108negative regulation of hydrolase activity (GO:0051346)2.63997897
109preassembly of GPI anchor in ER membrane (GO:0016254)2.63198768
110sialylation (GO:0097503)2.61363909
111response to amphetamine (GO:0001975)2.60862612
112basic amino acid transport (GO:0015802)2.60835194
113auditory receptor cell stereocilium organization (GO:0060088)2.60716363
114complement activation, alternative pathway (GO:0006957)2.60418621
115peristalsis (GO:0030432)2.59225500
116adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.58902597
117dopamine transport (GO:0015872)2.58096707
118prepulse inhibition (GO:0060134)2.57357063
119positive regulation of defense response to virus by host (GO:0002230)2.55394310
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54552948
121high-density lipoprotein particle remodeling (GO:0034375)2.54546696
122regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54217125
123multicellular organismal movement (GO:0050879)2.54090339
124musculoskeletal movement (GO:0050881)2.54090339
125nephron epithelium morphogenesis (GO:0072088)2.53917802
126nephron tubule morphogenesis (GO:0072078)2.53917802
127low-density lipoprotein particle clearance (GO:0034383)2.53746449
128regulation of endopeptidase activity (GO:0052548)2.51433177
129cellular ketone body metabolic process (GO:0046950)2.51000537
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50166107
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50166107
132protein polyglutamylation (GO:0018095)2.50115214
133neuron cell-cell adhesion (GO:0007158)2.49760676
134primary amino compound metabolic process (GO:1901160)2.49403465
135activated T cell proliferation (GO:0050798)2.49320901
136negative regulation of receptor-mediated endocytosis (GO:0048261)2.48618451
137startle response (GO:0001964)2.45973609
138fucosylation (GO:0036065)2.45831441
139negative regulation of interleukin-6 production (GO:0032715)2.45291942
140regulation of beta-amyloid formation (GO:1902003)2.44898809
141hindbrain development (GO:0030902)2.44443813
142hormone catabolic process (GO:0042447)2.44162834
143protein complex biogenesis (GO:0070271)2.43947286
144neural tube formation (GO:0001841)2.43169311
145protein localization to cilium (GO:0061512)2.42734141
146sperm motility (GO:0030317)2.41300421
147response to histamine (GO:0034776)2.39666231
148cilium morphogenesis (GO:0060271)2.39441569
149regulation of peptidase activity (GO:0052547)2.39253298
150negative regulation of oligodendrocyte differentiation (GO:0048715)2.38502681
151adaptation of signaling pathway (GO:0023058)2.37900079
152detection of mechanical stimulus involved in sensory perception (GO:0050974)2.37628185
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.37440009
154base-excision repair, AP site formation (GO:0006285)2.37193315
155negative regulation of response to food (GO:0032096)2.36787878
156negative regulation of appetite (GO:0032099)2.36787878
157regulation of dopamine secretion (GO:0014059)2.36564414
158cilium organization (GO:0044782)2.34405313
159lipid catabolic process (GO:0016042)2.33385067
160alpha-amino acid catabolic process (GO:1901606)2.32475495
161regulation of T cell apoptotic process (GO:0070232)2.30245841
162valine metabolic process (GO:0006573)2.29959828
163regulation of interleukin-10 production (GO:0032653)2.25805823
164cellular amino acid catabolic process (GO:0009063)2.22669527
165response to misfolded protein (GO:0051788)2.20882590
166L-serine transport (GO:0015825)2.20587392
167CDP-diacylglycerol biosynthetic process (GO:0016024)2.19958223
168myeloid cell homeostasis (GO:0002262)2.15916711
169anterior/posterior axis specification, embryo (GO:0008595)2.14431326
170regulation of reproductive process (GO:2000241)2.14027849
171phagocytosis, recognition (GO:0006910)2.13412196
172CDP-diacylglycerol metabolic process (GO:0046341)2.13131346
173regulation of amyloid precursor protein catabolic process (GO:1902991)2.11111390
174cellular response to epidermal growth factor stimulus (GO:0071364)2.09294016
175negative regulation of tumor necrosis factor production (GO:0032720)2.06743078
176triglyceride catabolic process (GO:0019433)2.05747867
177myelin maintenance (GO:0043217)2.04491839
178positive regulation of cholesterol transport (GO:0032376)2.03434187
179positive regulation of sterol transport (GO:0032373)2.03434187
180negative regulation of glucose import (GO:0046325)2.02563809
181plasma lipoprotein particle remodeling (GO:0034369)2.00483071
182protein-lipid complex remodeling (GO:0034368)2.00483071
183macromolecular complex remodeling (GO:0034367)2.00483071
184production of molecular mediator involved in inflammatory response (GO:0002532)15.7707912
185regulation of T cell tolerance induction (GO:0002664)15.1899984
186positive regulation of tolerance induction (GO:0002645)12.9729598
187sperm capacitation (GO:0048240)11.8328719
188regulation of tolerance induction (GO:0002643)11.2782309
189kynurenine metabolic process (GO:0070189)11.0274788
190COPI coating of Golgi vesicle (GO:0048205)1.98284497
191Golgi transport vesicle coating (GO:0048200)1.98284497
192negative regulation of leukocyte apoptotic process (GO:2000107)1.98084709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.71992662
2ZNF274_21170338_ChIP-Seq_K562_Hela4.23645959
3IKZF1_21737484_ChIP-ChIP_HCT116_Human4.22608349
4VDR_22108803_ChIP-Seq_LS180_Human3.70482258
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.48078736
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.47583465
7EZH2_22144423_ChIP-Seq_EOC_Human3.42584143
8AR_21572438_ChIP-Seq_LNCaP_Human3.26382879
9ZNF263_19887448_ChIP-Seq_K562_Human3.13199248
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.12116230
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10366595
12GBX2_23144817_ChIP-Seq_PC3_Human2.94092526
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.92966004
14IGF1R_20145208_ChIP-Seq_DFB_Human2.90721255
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.78989316
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71292121
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.54286543
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.50644196
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.41322074
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.41140607
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26733664
22SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.19319374
23CLOCK_20551151_ChIP-Seq_293T_Human2.16148317
24DNAJC2_21179169_ChIP-ChIP_NT2_Human2.16120194
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16047693
26GATA3_21867929_ChIP-Seq_TH1_Mouse2.14879556
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14842266
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.07966720
29GATA3_20176728_ChIP-ChIP_TSCs_Mouse2.07803827
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04808206
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99526035
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93631615
33EWS_26573619_Chip-Seq_HEK293_Human1.92858082
34SMAD1_18555785_Chip-Seq_ESCs_Mouse1.90152044
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.89947875
36TAF15_26573619_Chip-Seq_HEK293_Human1.89452566
37STAT1_17558387_ChIP-Seq_HELA_Human1.82040135
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81319752
39FLI1_21867929_ChIP-Seq_CD8_Mouse1.77042591
40BCAT_22108803_ChIP-Seq_LS180_Human1.76868868
41REST_19997604_ChIP-ChIP_NEURONS_Mouse1.76532467
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76493172
43P300_19829295_ChIP-Seq_ESCs_Human1.76376665
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75893193
45ER_23166858_ChIP-Seq_MCF-7_Human1.75053487
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72669767
47* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69165637
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63992852
49RAD21_21589869_ChIP-Seq_MESCs_Mouse1.62944453
50REST_21632747_ChIP-Seq_MESCs_Mouse1.62259650
51ESRRB_18555785_Chip-Seq_ESCs_Mouse1.61134776
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.60726967
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57659710
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56862726
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.53511057
56* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.51322975
57NANOG_19829295_ChIP-Seq_ESCs_Human1.50735258
58SOX2_19829295_ChIP-Seq_ESCs_Human1.50735258
59* TET1_21451524_ChIP-Seq_MESCs_Mouse1.50593019
60* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49969630
61TP53_22573176_ChIP-Seq_HFKS_Human1.49734389
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.48964368
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46045296
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.44831016
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44831016
66AR_25329375_ChIP-Seq_VCAP_Human1.43954327
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43688955
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43592228
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43491349
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42394198
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40960838
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39816162
73FUS_26573619_Chip-Seq_HEK293_Human1.38443878
74P68_20966046_ChIP-Seq_HELA_Human1.37818133
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36831777
76MYC_18940864_ChIP-ChIP_HL60_Human1.36373195
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.35823627
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35592505
79STAT3_23295773_ChIP-Seq_U87_Human1.34096082
80CTCF_18555785_Chip-Seq_ESCs_Mouse1.31794808
81SALL4_22934838_ChIP-ChIP_CD34+_Human1.31174059
82* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30536044
83BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.30236741
84SMAD4_21799915_ChIP-Seq_A2780_Human1.29996445
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29103727
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28604384
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28599993
88TCF4_23295773_ChIP-Seq_U87_Human1.28507070
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28256743
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27807703
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27807703
92RACK7_27058665_Chip-Seq_MCF-7_Human1.26984652
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26930232
94MYC_27129775_Chip-Seq_CORNEA_Mouse1.26155818
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.25129421
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24650013
97IRF1_19129219_ChIP-ChIP_H3396_Human1.24626883
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.22835934
99CBP_20019798_ChIP-Seq_JUKART_Human1.21746646
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21746646
101SMC4_20622854_ChIP-Seq_HELA_Human1.21340772
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20322796
103NCOR_22424771_ChIP-Seq_293T_Human1.19757044
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19009218
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.17188173
106VDR_24787735_ChIP-Seq_THP-1_Human1.17079183
107* SMAD4_21741376_ChIP-Seq_HESCs_Human1.17006510
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16907740
109* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16183493
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.15364640
111FOXH1_21741376_ChIP-Seq_ESCs_Human1.14190348
112MYC_19915707_ChIP-ChIP_AK7_Human1.13696741
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13179443
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.12974333
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12760783
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.12549447
117HOXB7_26014856_ChIP-Seq_BT474_Human1.11576243
118TCF4_22108803_ChIP-Seq_LS180_Human1.11523946
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11068273
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10362099
121TP63_17297297_ChIP-ChIP_HaCaT_Human1.09924765
122AR_20517297_ChIP-Seq_VCAP_Human1.09617344
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09475257
124* REST_18959480_ChIP-ChIP_MESCs_Mouse1.09385388
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09048429
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08915456
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08902988
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08073774
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.05950263
130HTT_18923047_ChIP-ChIP_STHdh_Human1.05513742
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.05307755
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05223363
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05199916
134BCOR_27268052_Chip-Seq_Bcells_Human1.04824342
135PIAS1_25552417_ChIP-Seq_VCAP_Human1.04131940
136RUNX2_22187159_ChIP-Seq_PCA_Human1.03927397
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03823581
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03561085
139BCL6_27268052_Chip-Seq_Bcells_Human1.02069605
140P300_27268052_Chip-Seq_Bcells_Human1.01689857
141DROSHA_22980978_ChIP-Seq_HELA_Human1.01334623
142RARB_24833708_ChIP-Seq_LIVER_Mouse1.00683309
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00358316
144* TAF2_19829295_ChIP-Seq_ESCs_Human0.99971474
145ERA_21632823_ChIP-Seq_H3396_Human0.99962419
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99818066
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99119890
148MYC_19829295_ChIP-Seq_ESCs_Human0.98612038
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98375681
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.98252251
151CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98055869
152SOX2_20726797_ChIP-Seq_SW620_Human0.97341795
153NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97120293
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96927805
155GATA3_26560356_Chip-Seq_TH2_Human0.96125191
156EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96001112
157* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95897388
158SOX2_18555785_Chip-Seq_ESCs_Mouse0.95481375
159KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95275662
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.94754874
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.94512665
162NANOG_20526341_ChIP-Seq_ESCs_Human0.94162067
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.92401084
164NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91719975
165PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90585743
166TP53_20018659_ChIP-ChIP_R1E_Mouse0.90163190
167CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89248930
168RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89040337
169KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88125366
170POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88049279
171TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88049279
172CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87941378
173OCT4_20526341_ChIP-Seq_ESCs_Human0.87603171
174TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87338033
175E2F1_20622854_ChIP-Seq_HELA_Human0.85879452
176TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85869993
177EZH2_27304074_Chip-Seq_ESCs_Mouse0.85412876
178NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84733179
179GATA3_21867929_ChIP-Seq_CD8_Mouse0.83220613
180KDM2B_26808549_Chip-Seq_REH_Human0.82511325
181SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82361947
182RNF2_27304074_Chip-Seq_NSC_Mouse0.82049360
183NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81896279
184NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81459334
185SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81436883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.14739280
2MP0003195_calcinosis5.52720427
3MP0002254_reproductive_system_inflammat5.38402313
4MP0004043_abnormal_pH_regulation4.84520124
5MP0010234_abnormal_vibrissa_follicle4.42604303
6MP0002139_abnormal_hepatobiliary_system4.05906544
7MP0005410_abnormal_fertilization3.66862359
8MP0005058_abnormal_lysosome_morphology3.51352894
9MP0002102_abnormal_ear_morphology3.10221369
10MP0003329_amyloid_beta_deposits3.05318401
11MP0008872_abnormal_physiological_respon3.04046709
12MP0001968_abnormal_touch/_nociception3.02686755
13MP0009046_muscle_twitch2.65037230
14MP0001986_abnormal_taste_sensitivity2.60258303
15MP0004885_abnormal_endolymph2.56645903
16MP0002736_abnormal_nociception_after2.55132041
17MP0002735_abnormal_chemical_nociception2.54064925
18MP0008877_abnormal_DNA_methylation2.43335871
19MP0000003_abnormal_adipose_tissue2.15502025
20MP0009745_abnormal_behavioral_response2.10942187
21MP0003705_abnormal_hypodermis_morpholog2.08597997
22MP0005551_abnormal_eye_electrophysiolog2.06757777
23MP0000604_amyloidosis2.03862590
24MP0005084_abnormal_gallbladder_morpholo2.03582311
25MP0005360_urolithiasis2.01277211
26MP0003566_abnormal_cell_adhesion1.99304066
27MP0005646_abnormal_pituitary_gland1.91630200
28MP0010329_abnormal_lipoprotein_level1.91514841
29MP0006276_abnormal_autonomic_nervous1.90618696
30MP0002168_other_aberrant_phenotype1.88590446
31MP0000537_abnormal_urethra_morphology1.86618649
32MP0004147_increased_porphyrin_level1.84067278
33MP0004142_abnormal_muscle_tone1.83870274
34MP0001970_abnormal_pain_threshold1.82283236
35MP0002638_abnormal_pupillary_reflex1.81259636
36MP0005464_abnormal_platelet_physiology1.80424080
37MP0002272_abnormal_nervous_system1.79663189
38MP0001905_abnormal_dopamine_level1.75766834
39MP0002653_abnormal_ependyma_morphology1.74759088
40MP0001853_heart_inflammation1.73763086
41MP0000569_abnormal_digit_pigmentation1.67180163
42MP0005365_abnormal_bile_salt1.64258272
43MP0000230_abnormal_systemic_arterial1.64021368
44MP0001486_abnormal_startle_reflex1.62148638
45MP0001501_abnormal_sleep_pattern1.55025172
46MP0005085_abnormal_gallbladder_physiolo1.51531312
47MP0003787_abnormal_imprinting1.50107126
48MP0003300_gastrointestinal_ulcer1.46079419
49MP0005377_hearing/vestibular/ear_phenot1.45370948
50MP0003878_abnormal_ear_physiology1.45370948
51MP0005174_abnormal_tail_pigmentation1.45115983
52MP0002067_abnormal_sensory_capabilities1.44379431
53MP0002572_abnormal_emotion/affect_behav1.44322958
54MP0005375_adipose_tissue_phenotype1.44012620
55MP0005645_abnormal_hypothalamus_physiol1.42452964
56MP0003690_abnormal_glial_cell1.41906635
57MP0004133_heterotaxia1.41342896
58MP0002064_seizures1.41157123
59MP0001765_abnormal_ion_homeostasis1.40946314
60MP0004742_abnormal_vestibular_system1.40769674
61MP0000534_abnormal_ureter_morphology1.38684849
62MP0001440_abnormal_grooming_behavior1.38623933
63MP0009643_abnormal_urine_homeostasis1.37869403
64MP0002796_impaired_skin_barrier1.37765427
65MP0001756_abnormal_urination1.35473048
66MP0000427_abnormal_hair_cycle1.34136999
67MP0010386_abnormal_urinary_bladder1.33284628
68MP0005253_abnormal_eye_physiology1.33038420
69MP0005167_abnormal_blood-brain_barrier1.32912154
70MP0003011_delayed_dark_adaptation1.32747503
71MP0006072_abnormal_retinal_apoptosis1.32734551
72MP0004130_abnormal_muscle_cell1.31118639
73MP0005332_abnormal_amino_acid1.29072221
74MP0005083_abnormal_biliary_tract1.28554009
75MP0008438_abnormal_cutaneous_collagen1.28446880
76MP0003136_yellow_coat_color1.26661677
77MP0008775_abnormal_heart_ventricle1.26511756
78MP0002063_abnormal_learning/memory/cond1.21905095
79MP0003635_abnormal_synaptic_transmissio1.19503725
80MP0002734_abnormal_mechanical_nocicepti1.19232604
81MP0003724_increased_susceptibility_to1.17847704
82MP0004185_abnormal_adipocyte_glucose1.15568195
83MP0002837_dystrophic_cardiac_calcinosis1.14039411
84MP0003698_abnormal_male_reproductive1.13764502
85MP0003880_abnormal_central_pattern1.11242797
86MP0002557_abnormal_social/conspecific_i1.11241153
87MP0005395_other_phenotype1.10647189
88MP0004858_abnormal_nervous_system1.09162434
89MP0003718_maternal_effect1.08786218
90MP0002928_abnormal_bile_duct1.07017501
91MP0002693_abnormal_pancreas_physiology1.06312356
92MP0002118_abnormal_lipid_homeostasis1.06126431
93MP0005408_hypopigmentation1.05595386
94MP0001984_abnormal_olfaction1.05307262
95MP0000631_abnormal_neuroendocrine_gland1.05242180
96MP0009840_abnormal_foam_cell1.04502979
97MP0002909_abnormal_adrenal_gland1.03987885
98MP0003638_abnormal_response/metabolism_1.03323404
99MP0004924_abnormal_behavior1.01645372
100MP0005386_behavior/neurological_phenoty1.01645372
101MP0005636_abnormal_mineral_homeostasis1.00078326
102MP0001529_abnormal_vocalization0.98690619
103MP0001502_abnormal_circadian_rhythm0.98552625
104MP0003123_paternal_imprinting0.98392396
105MP0005275_abnormal_skin_tensile0.96374815
106MP0003646_muscle_fatigue0.95985152
107MP0009764_decreased_sensitivity_to0.95013300
108MP0002089_abnormal_postnatal_growth/wei0.94607812
109MP0002136_abnormal_kidney_physiology0.93210281
110MP0003879_abnormal_hair_cell0.93171171
111MP0002277_abnormal_respiratory_mucosa0.93038209
112MP0005671_abnormal_response_to0.92912321
113MP0005389_reproductive_system_phenotype0.91897371
114MP0006138_congestive_heart_failure0.91867497
115MP0005584_abnormal_enzyme/coenzyme_acti0.90709194
116MP0003632_abnormal_nervous_system0.90701317
117MP0004084_abnormal_cardiac_muscle0.90552014
118MP0008995_early_reproductive_senescence0.90080333
119MP0002234_abnormal_pharynx_morphology0.89192376
120MP0010368_abnormal_lymphatic_system0.88878257
121MP0005448_abnormal_energy_balance0.88727123
122MP0002896_abnormal_bone_mineralization0.88342910
123MP0004215_abnormal_myocardial_fiber0.87006045
124MP0002160_abnormal_reproductive_system0.86234327
125MP0004272_abnormal_basement_membrane0.84912015
126MP0004036_abnormal_muscle_relaxation0.84140024
127MP0003191_abnormal_cellular_cholesterol0.84039164
128MP0001849_ear_inflammation0.83919280
129MP0000026_abnormal_inner_ear0.83679094
130MP0001664_abnormal_digestion0.81755836
131MP0000747_muscle_weakness0.79514877
132MP0005623_abnormal_meninges_morphology0.79318433
133MP0000609_abnormal_liver_physiology0.78439255
134MP0002069_abnormal_eating/drinking_beha0.77387555
135MP0000015_abnormal_ear_pigmentation0.77041358
136MP0002095_abnormal_skin_pigmentation0.76898137
137MP0005319_abnormal_enzyme/_coenzyme0.76078470
138MP0005666_abnormal_adipose_tissue0.76070130
139MP0001919_abnormal_reproductive_system0.75875061
140MP0002938_white_spotting0.73103527
141MP0001663_abnormal_digestive_system0.72018527
142MP0001929_abnormal_gametogenesis0.71550276
143MP0005195_abnormal_posterior_eye0.71478602
144MP0009379_abnormal_foot_pigmentation0.71276329
145MP0003828_pulmonary_edema0.70715272
146MP0003075_altered_response_to0.70204517
147MP0009384_cardiac_valve_regurgitation0.69705772
148MP0002161_abnormal_fertility/fecundity0.68603510
149MP0008875_abnormal_xenobiotic_pharmacok0.68017456
150MP0009053_abnormal_anal_canal0.67969307
151MP0000538_abnormal_urinary_bladder0.67604354
152MP0003221_abnormal_cardiomyocyte_apopto0.67204805
153MP0002933_joint_inflammation0.67012503
154MP0004859_abnormal_synaptic_plasticity0.66785989
155MP0002733_abnormal_thermal_nociception0.66715894
156MP0004145_abnormal_muscle_electrophysio0.66340750
157MP0005670_abnormal_white_adipose0.66301986
158MP0005451_abnormal_body_composition0.65748778
159MP0003806_abnormal_nucleotide_metabolis0.63648733
160MP0003252_abnormal_bile_duct0.60351165
161MP0000372_irregular_coat_pigmentation0.59944177
162MP0002876_abnormal_thyroid_physiology0.59373450
163MP0005334_abnormal_fat_pad0.59337750
164MP0004270_analgesia0.59283684
165MP0000920_abnormal_myelination0.59193576
166MP0010678_abnormal_skin_adnexa0.58529875
167MP0003631_nervous_system_phenotype0.56307385
168MP0002971_abnormal_brown_adipose0.55408240
169MP0000249_abnormal_blood_vessel0.55150546
170MP0001485_abnormal_pinna_reflex0.54702450
171MP0001348_abnormal_lacrimal_gland0.53046695
172MP0000462_abnormal_digestive_system0.52432678
173MP0002972_abnormal_cardiac_muscle0.52156837
174MP0005535_abnormal_body_temperature0.52001808
175MP0002295_abnormal_pulmonary_circulatio0.50932518
176MP0003634_abnormal_glial_cell0.50630891

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)5.76086286
2Potter facies (HP:0002009)5.19305486
3Facial shape deformation (HP:0011334)5.19305486
4Vascular calcification (HP:0004934)5.18870627
5Hypophosphatemic rickets (HP:0004912)5.02088908
6Cardiovascular calcification (HP:0011915)4.77545634
7Complement deficiency (HP:0004431)4.54847812
8Pancreatic cysts (HP:0001737)4.48085609
9Malnutrition (HP:0004395)4.42953144
10Abnormality of midbrain morphology (HP:0002418)4.19643247
11Molar tooth sign on MRI (HP:0002419)4.19643247
12Hyperventilation (HP:0002883)4.10727464
13True hermaphroditism (HP:0010459)4.10343881
14Neurofibrillary tangles (HP:0002185)4.10153893
15Pancreatic fibrosis (HP:0100732)4.10048021
16Choroideremia (HP:0001139)3.95734337
17Gout (HP:0001997)3.93772060
18Cerebral inclusion bodies (HP:0100314)3.91603256
19Congenital stationary night blindness (HP:0007642)3.66978853
20Abnormality of the fovea (HP:0000493)3.62797175
21Recurrent gram-negative bacterial infections (HP:0005420)3.41028611
22Nephronophthisis (HP:0000090)3.36661886
23Widely patent fontanelles and sutures (HP:0004492)3.35988982
24Abnormality of complement system (HP:0005339)3.35347093
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.29475502
26Absent/shortened dynein arms (HP:0200106)3.29475502
27Xanthomatosis (HP:0000991)3.28523500
28Hyperglycinuria (HP:0003108)3.23883971
29Abnormal respiratory epithelium morphology (HP:0012253)3.22240135
30Abnormal respiratory motile cilium morphology (HP:0005938)3.22240135
31Infantile muscular hypotonia (HP:0008947)3.18386268
32Supranuclear gaze palsy (HP:0000605)3.16695526
33Choreoathetosis (HP:0001266)3.16430645
34Rickets (HP:0002748)3.14752513
35Abnormal hemoglobin (HP:0011902)3.13735134
36Neoplasm of the heart (HP:0100544)3.12338661
37Pendular nystagmus (HP:0012043)3.00819326
38Large for gestational age (HP:0001520)2.99502868
39Abnormality of alanine metabolism (HP:0010916)2.94070299
40Hyperalaninemia (HP:0003348)2.94070299
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94070299
42Segmental peripheral demyelination/remyelination (HP:0003481)2.90301445
43Abnormality of the renal medulla (HP:0100957)2.87535889
44Intention tremor (HP:0002080)2.87135879
45Congenital, generalized hypertrichosis (HP:0004540)2.85828043
46Abolished electroretinogram (ERG) (HP:0000550)2.81306525
47Inability to walk (HP:0002540)2.80513956
48Abnormality of the renal cortex (HP:0011035)2.80191441
49Hyperglycinemia (HP:0002154)2.77921585
50Type II lissencephaly (HP:0007260)2.76503710
51Medial flaring of the eyebrow (HP:0010747)2.75867132
52Cystic liver disease (HP:0006706)2.75305891
53Agitation (HP:0000713)2.74988842
54Attenuation of retinal blood vessels (HP:0007843)2.72071667
55Broad-based gait (HP:0002136)2.70548008
56Abnormality of serine family amino acid metabolism (HP:0010894)2.67766676
57Abnormality of glycine metabolism (HP:0010895)2.67766676
58Deep venous thrombosis (HP:0002625)2.62455849
59Hypopigmentation of the fundus (HP:0007894)2.60483136
60Pili torti (HP:0003777)2.57718712
61Absent speech (HP:0001344)2.57612261
62Abnormality of purine metabolism (HP:0004352)2.57337703
63Prolonged bleeding time (HP:0003010)2.57291233
64Acanthosis nigricans (HP:0000956)2.57151927
65Furrowed tongue (HP:0000221)2.56166795
66Parakeratosis (HP:0001036)2.55186571
67Muscle fiber splitting (HP:0003555)2.54930454
68Decreased central vision (HP:0007663)2.51575892
69Testicular atrophy (HP:0000029)2.50487754
70Hemiplegia (HP:0002301)2.49184315
71Abnormal ciliary motility (HP:0012262)2.45553636
72Protruding tongue (HP:0010808)2.44846046
73Progressive cerebellar ataxia (HP:0002073)2.44361740
74Clumsiness (HP:0002312)2.43940578
75Vacuolated lymphocytes (HP:0001922)2.41005272
76Increased connective tissue (HP:0009025)2.40144419
77Fair hair (HP:0002286)2.38463659
78Lissencephaly (HP:0001339)2.37091152
79Peripheral hypomyelination (HP:0007182)2.36911301
80Polar cataract (HP:0010696)2.36825176
81Male pseudohermaphroditism (HP:0000037)2.35964437
82Gait imbalance (HP:0002141)2.34953301
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32921140
84Sclerocornea (HP:0000647)2.32790484
85Increased corneal curvature (HP:0100692)2.31951753
86Keratoconus (HP:0000563)2.31951753
87Difficulty running (HP:0009046)2.29652344
88Renal cortical cysts (HP:0000803)2.28337629
89Prominent nose (HP:0000448)2.24179465
90Hyporeflexia of lower limbs (HP:0002600)2.23495479
9111 pairs of ribs (HP:0000878)2.21451596
92Stomatitis (HP:0010280)2.21137419
93Abnormality of secondary sexual hair (HP:0009888)2.17895581
94Abnormality of the axillary hair (HP:0100134)2.17895581
95Severe muscular hypotonia (HP:0006829)2.16922792
96Mesangial abnormality (HP:0001966)2.15681225
97Febrile seizures (HP:0002373)2.15417463
98Restlessness (HP:0000711)2.15006882
99Congenital primary aphakia (HP:0007707)2.14265318
100Tubular atrophy (HP:0000092)2.14150112
101Congenital hepatic fibrosis (HP:0002612)2.13318581
102Progressive neurologic deterioration (HP:0002344)2.12523586
103Epidermoid cyst (HP:0200040)2.12361800
104Genetic anticipation (HP:0003743)2.12015466
105Ketoacidosis (HP:0001993)2.11446273
106Abnormal rod and cone electroretinograms (HP:0008323)2.10522592
107Hemiparesis (HP:0001269)2.10286025
108Chronic hepatic failure (HP:0100626)2.09210324
109Irregular vertebral endplates (HP:0003301)2.08426049
110Ketosis (HP:0001946)2.07929482
111Focal segmental glomerulosclerosis (HP:0000097)2.07859369
112Anencephaly (HP:0002323)2.06190624
113Petechiae (HP:0000967)2.05865786
114Thin bony cortex (HP:0002753)2.04931084
115Radial bowing (HP:0002986)2.04207584
116Nephrogenic diabetes insipidus (HP:0009806)2.04190885
117Hemorrhage of the eye (HP:0011885)2.03347259
118Ventricular fibrillation (HP:0001663)2.02453917
119Intrahepatic cholestasis (HP:0001406)2.00795567
120Abnormal drinking behavior (HP:0030082)2.00731231
121Polydipsia (HP:0001959)2.00731231
122Skin nodule (HP:0200036)2.00112387
123Gaze-evoked nystagmus (HP:0000640)1.99547864
124Thyroid-stimulating hormone excess (HP:0002925)1.99347250
1253-Methylglutaconic aciduria (HP:0003535)1.98674746
126Progressive inability to walk (HP:0002505)1.98543118
127Ulnar claw (HP:0001178)1.98067832
128Osteomalacia (HP:0002749)1.97960738
129Hyperlipoproteinemia (HP:0010980)1.96460879
130Pachygyria (HP:0001302)1.95823339
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95297929
132Focal motor seizures (HP:0011153)1.94390595
133Bundle branch block (HP:0011710)1.94376773
134Widely spaced teeth (HP:0000687)1.93762662
135Hyperparathyroidism (HP:0000843)1.93523385
136Gait ataxia (HP:0002066)1.93387529
137Abnormality of abdominal situs (HP:0011620)1.93282150
138Abdominal situs inversus (HP:0003363)1.93282150
139Multiple enchondromatosis (HP:0005701)1.92779321
140Right ventricular cardiomyopathy (HP:0011663)1.92516058
141Generalized hypopigmentation of hair (HP:0011358)1.92310519
142Hypertriglyceridemia (HP:0002155)1.92248705
143Acute necrotizing encephalopathy (HP:0006965)1.91673767
144Wide cranial sutures (HP:0010537)1.91288716
145Optic nerve hypoplasia (HP:0000609)1.91242645
146Increased purine levels (HP:0004368)1.91111789
147Hyperuricemia (HP:0002149)1.91111789
148Abnormal respiratory motile cilium physiology (HP:0012261)1.91090040
149Hypothermia (HP:0002045)1.91061515
150Dysostosis multiplex (HP:0000943)1.89342076
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.88622876
152Abnormality of the vertebral endplates (HP:0005106)1.88572176
153Hepatoblastoma (HP:0002884)1.88319882
154Broad distal phalanx of finger (HP:0009836)1.88128721
155Exercise-induced muscle cramps (HP:0003710)1.87141334
156Acute encephalopathy (HP:0006846)1.86251721
157Hypoalphalipoproteinemia (HP:0003233)1.86043847
158Abnormal cartilage morphology (HP:0002763)1.85391544
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85320669
160Chorioretinal atrophy (HP:0000533)1.84957786
161Concave nail (HP:0001598)1.83818583
162Patellar aplasia (HP:0006443)1.82063339
163Progressive microcephaly (HP:0000253)1.81507255
164Congenital sensorineural hearing impairment (HP:0008527)1.80908115
165Tetraplegia (HP:0002445)1.80498928
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80333326
167Abnormal hair laboratory examination (HP:0003328)1.80234149
168Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79793796
169Optic disc pallor (HP:0000543)1.78223003
170Abnormality of nucleobase metabolism (HP:0010932)1.77848523
171Polyphagia (HP:0002591)1.77192518
172Hyperammonemia (HP:0001987)1.75592706
173Nephritis (HP:0000123)1.75247171
174Aplasia/Hypoplasia of the patella (HP:0006498)1.74473474
175Polyuria (HP:0000103)1.74060509
176Selective tooth agenesis (HP:0001592)1.74056583
177Mitochondrial inheritance (HP:0001427)1.73550580
178Mutism (HP:0002300)1.72805649
179Calf muscle hypertrophy (HP:0008981)1.72491053
180Progressive macrocephaly (HP:0004481)1.71400569
181Congenital ichthyosiform erythroderma (HP:0007431)1.71335507
182Menorrhagia (HP:0000132)1.71285265
183Cerebellar dysplasia (HP:0007033)1.71054442
184Hypomagnesemia (HP:0002917)1.70960304
185Stomach cancer (HP:0012126)1.70926493
186Dyskinesia (HP:0100660)1.70550241
187Shawl scrotum (HP:0000049)1.70488833
188Difficulty climbing stairs (HP:0003551)1.69969720
189Aplasia/Hypoplasia of the fovea (HP:0008060)1.69111260
190Onion bulb formation (HP:0003383)1.68061816
191Bony spicule pigmentary retinopathy (HP:0007737)1.68050809
192Upper limb muscle weakness (HP:0003484)1.65717810
193Hyperphosphatemia (HP:0002905)1.64869076
194Ileus (HP:0002595)1.64557125
195Metaphyseal cupping (HP:0003021)1.64425624
196Systemic lupus erythematosus (HP:0002725)1.64235156
197Death in infancy (HP:0001522)1.63938082
198Glomerulosclerosis (HP:0000096)1.62485043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.12322188
2MST1R4.10292162
3MST43.83427974
4ERN13.51463581
5LMTK23.07301761
6MAP4K22.97278385
7BMPR1B2.92945869
8PKN22.81989594
9TLK12.80112377
10GRK12.76223864
11RIPK42.62849960
12LRRK22.54707552
13WNK32.48164076
14INSRR2.45887231
15ACVR1B2.41063916
16AKT32.40764003
17EPHB12.31857904
18ZAK2.24378631
19SIK12.19120704
20FGFR42.17427376
21PDGFRA2.16699669
22FGFR22.15166609
23STK392.15162814
24DAPK22.10865368
25EPHB22.01551724
26FER2.01357999
27MAPK132.01029681
28EPHA21.93881578
29MARK11.92187842
30MET1.88770326
31CASK1.85423360
32WNK41.84789176
33PINK11.70719920
34TRIB31.62807730
35MAP2K71.62344999
36MAP3K41.61325356
37NUAK11.61056255
38TIE11.56393644
39MAPK151.50049681
40LATS21.46946492
41TAOK31.42058060
42TNK21.41436799
43TXK1.37605502
44MYLK1.37345272
45LATS11.36299457
46DYRK21.36206434
47TYRO31.31707929
48TEC1.30193951
49PAK31.27194314
50KSR21.26540137
51PRKD31.26364168
52PTK61.26116466
53MAP3K21.25242456
54ADRBK11.23542464
55MAPKAPK31.22824454
56STK161.13037896
57PTK21.11135670
58PTK2B1.10567459
59INSR1.09834369
60TTN1.08830165
61STK101.08646760
62RET1.08045305
63TGFBR11.06821578
64ALK1.02443921
65CAMKK21.01568438
66CSNK1G31.00218761
67FGFR31.00206483
68PAK20.99899954
69MAP3K130.98214497
70SYK0.98175131
71PAK60.96337643
72PLK20.95957407
73NTRK10.94991194
74TRIM280.94185256
75PRKCH0.93351302
76CSNK1G20.92711134
77SIK20.91242704
78TESK10.90620973
79PRKCE0.88059395
80PNCK0.86970292
81PDK30.86692484
82PDK40.86692484
83OXSR10.85388263
84NTRK30.84734889
85FRK0.83066164
86CSNK1G10.82844703
87FLT30.80757161
88VRK10.78965638
89JAK20.77625155
90CSNK1A1L0.74584803
91STK380.73537001
92KIT0.72911960
93PRKCQ0.72229565
94GSK3A0.71599490
95STK38L0.71480588
96MAP2K40.71451461
97IKBKB0.71216397
98MUSK0.69411801
99ABL20.68386503
100PDK20.67981390
101MAP2K10.65882604
102CSF1R0.65242563
103PAK40.65216765
104ITK0.64442312
105EPHA40.63371283
106PRKCG0.63248037
107CDK60.63035314
108FGFR10.61957951
109EEF2K0.61940060
110CCNB10.61853800
111KSR10.61297682
112MAP2K60.61225378
113CDK50.59159161
114PDGFRB0.59079630
115PRKD10.58696111
116DDR20.58585968
117MAP3K70.58561965
118RPS6KA50.57617641
119PRKCI0.56017328
120CSNK1E0.55755281
121CAMK2A0.55488197
122MKNK20.54901391
123IRAK10.52828773
124PRKACG0.52798761
125PIK3CA0.52352319
126CDK190.51082235
127NEK10.49229221
128GRK60.48259394
129BTK0.48139674
130BCKDK0.47493968
131SRC0.47213457
132WNK10.47182229
133PDPK10.46830456
134PRKCZ0.46127606
135IGF1R0.46093140
136MAP3K60.45411163
137NEK20.45015210
138ERBB20.44438242
139PKN10.43986965
140PRKG20.43282959
141FYN0.43179420
142BCR0.42657165
143NTRK20.42552608
144LYN0.42292394
145LIMK10.42260992
146MAP3K110.41671819
147PDK10.41503610
148TTK0.41429163
149PRKACA0.40938341
150BMX0.39280053
151MAP3K120.39145222
152MAP2K20.38985928
153MAP4K10.37423254
154CSNK1D0.36991841
155MATK0.34978202
156PRKCA0.34143695
157ROCK20.34081215
158EGFR0.33984196
159MAPKAPK50.33751060
160RIPK10.33676521
161MAP3K90.31987648
162CSK0.31718867
163MINK10.30678837
164FES0.30619109
165MAP3K80.30321225
166SCYL20.30266732
167PHKG10.30038656
168PHKG20.30038656
169GRK50.29826119
170PRKG10.29574674
171LCK0.28414036
172CSNK1A10.27554250
173CAMK10.27361453
174PLK30.27107101
175CHUK0.27007073

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.36058247
2Glutathione metabolism_Homo sapiens_hsa004804.88995656
3Arachidonic acid metabolism_Homo sapiens_hsa005904.00326389
4Tryptophan metabolism_Homo sapiens_hsa003803.66227474
5African trypanosomiasis_Homo sapiens_hsa051433.65841912
6Thyroid hormone synthesis_Homo sapiens_hsa049183.64378615
7Selenocompound metabolism_Homo sapiens_hsa004503.18095577
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.95328114
9Phototransduction_Homo sapiens_hsa047442.82691143
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.77356370
11Linoleic acid metabolism_Homo sapiens_hsa005912.70478108
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60081918
13Nicotine addiction_Homo sapiens_hsa050332.34583509
14Vitamin B6 metabolism_Homo sapiens_hsa007502.31800837
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30021559
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24710778
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17805879
18Sulfur metabolism_Homo sapiens_hsa009201.90159718
19Fatty acid degradation_Homo sapiens_hsa000711.89325586
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88354281
21Arginine biosynthesis_Homo sapiens_hsa002201.87431101
22Fatty acid metabolism_Homo sapiens_hsa012121.84423223
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.81888178
24Ether lipid metabolism_Homo sapiens_hsa005651.80788024
25Oxidative phosphorylation_Homo sapiens_hsa001901.78982634
26Morphine addiction_Homo sapiens_hsa050321.71596880
27Regulation of autophagy_Homo sapiens_hsa041401.64762616
28PPAR signaling pathway_Homo sapiens_hsa033201.64486901
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58772278
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56145430
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50141683
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.49128076
33Taste transduction_Homo sapiens_hsa047421.48060105
34Glycerolipid metabolism_Homo sapiens_hsa005611.47625822
35Parkinsons disease_Homo sapiens_hsa050121.46155331
36Serotonergic synapse_Homo sapiens_hsa047261.38696163
37ABC transporters_Homo sapiens_hsa020101.35330132
38Salivary secretion_Homo sapiens_hsa049701.32628653
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30462437
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29193257
41Caffeine metabolism_Homo sapiens_hsa002321.28540260
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24967213
43Lysosome_Homo sapiens_hsa041421.16062124
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14939898
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09903705
46Asthma_Homo sapiens_hsa053101.09789215
47Complement and coagulation cascades_Homo sapiens_hsa046101.06938291
48Folate biosynthesis_Homo sapiens_hsa007901.06549562
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.05149752
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04057649
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02851407
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02475630
53Insulin secretion_Homo sapiens_hsa049110.98783758
54Propanoate metabolism_Homo sapiens_hsa006400.95924314
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.94268658
56Primary immunodeficiency_Homo sapiens_hsa053400.92572043
57Type I diabetes mellitus_Homo sapiens_hsa049400.91622816
58RNA polymerase_Homo sapiens_hsa030200.90338371
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90047996
60Gastric acid secretion_Homo sapiens_hsa049710.89879525
61Fat digestion and absorption_Homo sapiens_hsa049750.87427199
62Cardiac muscle contraction_Homo sapiens_hsa042600.87209935
63Bile secretion_Homo sapiens_hsa049760.86758866
64Butanoate metabolism_Homo sapiens_hsa006500.86529119
65Collecting duct acid secretion_Homo sapiens_hsa049660.85962817
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85297072
67Renin secretion_Homo sapiens_hsa049240.85256436
68Basal transcription factors_Homo sapiens_hsa030220.82583944
69Ovarian steroidogenesis_Homo sapiens_hsa049130.82240280
70beta-Alanine metabolism_Homo sapiens_hsa004100.81497973
71Fanconi anemia pathway_Homo sapiens_hsa034600.81131517
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79838260
73Calcium signaling pathway_Homo sapiens_hsa040200.79067731
74Platelet activation_Homo sapiens_hsa046110.78933391
75Starch and sucrose metabolism_Homo sapiens_hsa005000.77790243
76Cocaine addiction_Homo sapiens_hsa050300.76746528
77Biosynthesis of amino acids_Homo sapiens_hsa012300.76578620
78Alzheimers disease_Homo sapiens_hsa050100.75974630
79Phenylalanine metabolism_Homo sapiens_hsa003600.75777622
80Graft-versus-host disease_Homo sapiens_hsa053320.74524424
81Pyruvate metabolism_Homo sapiens_hsa006200.73903051
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73630208
83Huntingtons disease_Homo sapiens_hsa050160.73135309
84Hematopoietic cell lineage_Homo sapiens_hsa046400.72289803
85Estrogen signaling pathway_Homo sapiens_hsa049150.71561501
86Protein export_Homo sapiens_hsa030600.70465301
87Homologous recombination_Homo sapiens_hsa034400.70104860
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69752927
89Long-term potentiation_Homo sapiens_hsa047200.69310167
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69196025
91Arginine and proline metabolism_Homo sapiens_hsa003300.68564989
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68006802
93Carbon metabolism_Homo sapiens_hsa012000.67755555
94GABAergic synapse_Homo sapiens_hsa047270.67708159
95Allograft rejection_Homo sapiens_hsa053300.67681292
96Vibrio cholerae infection_Homo sapiens_hsa051100.66979741
97Long-term depression_Homo sapiens_hsa047300.65229960
98Cholinergic synapse_Homo sapiens_hsa047250.64905844
99Autoimmune thyroid disease_Homo sapiens_hsa053200.64252158
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62097731
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.61096315
102Rheumatoid arthritis_Homo sapiens_hsa053230.59560908
103Prion diseases_Homo sapiens_hsa050200.59152105
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.58658047
105Retinol metabolism_Homo sapiens_hsa008300.58094547
106Staphylococcus aureus infection_Homo sapiens_hsa051500.57878970
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54505884
108Circadian entrainment_Homo sapiens_hsa047130.53963082
109Purine metabolism_Homo sapiens_hsa002300.53036093
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52229847
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51903101
112RNA degradation_Homo sapiens_hsa030180.50760467
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50702589
114Circadian rhythm_Homo sapiens_hsa047100.48836635
115Histidine metabolism_Homo sapiens_hsa003400.48572829
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48286610
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.47266099
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45053047
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44730492
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44675642
121Tyrosine metabolism_Homo sapiens_hsa003500.42805489
122Fatty acid biosynthesis_Homo sapiens_hsa000610.42522768
123Metabolic pathways_Homo sapiens_hsa011000.42317578
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.41590610
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.41140698
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40967388
127Pancreatic secretion_Homo sapiens_hsa049720.40366843
128Fatty acid elongation_Homo sapiens_hsa000620.39955319
129Synaptic vesicle cycle_Homo sapiens_hsa047210.39728806
130Oocyte meiosis_Homo sapiens_hsa041140.39419562
131Amphetamine addiction_Homo sapiens_hsa050310.38622669
132Tight junction_Homo sapiens_hsa045300.38357203
133Mineral absorption_Homo sapiens_hsa049780.37208182
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37064563
135Pyrimidine metabolism_Homo sapiens_hsa002400.36565070
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34791734
137Chemical carcinogenesis_Homo sapiens_hsa052040.34517217
138Pentose phosphate pathway_Homo sapiens_hsa000300.32874667
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31619130
140Sulfur relay system_Homo sapiens_hsa041220.31564402
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31190013
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.30338381
143Peroxisome_Homo sapiens_hsa041460.29576634
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28162118
145Glutamatergic synapse_Homo sapiens_hsa047240.26599534
146Glioma_Homo sapiens_hsa052140.25794702
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25607932
148GnRH signaling pathway_Homo sapiens_hsa049120.25455507
149Glucagon signaling pathway_Homo sapiens_hsa049220.24418427
150Melanogenesis_Homo sapiens_hsa049160.21291933
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20944139
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20593540
153Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19830159
154Pertussis_Homo sapiens_hsa051330.18085815
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.17897475
156N-Glycan biosynthesis_Homo sapiens_hsa005100.16241915
157Olfactory transduction_Homo sapiens_hsa047400.14394278
158cAMP signaling pathway_Homo sapiens_hsa040240.14103191
159Insulin resistance_Homo sapiens_hsa049310.14033618
160Dopaminergic synapse_Homo sapiens_hsa047280.13920185

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »