LY6G6C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.23776218
2sphingoid metabolic process (GO:0046519)8.95602734
3keratinocyte proliferation (GO:0043616)7.77699423
4keratinocyte differentiation (GO:0030216)7.44341803
5sphingosine metabolic process (GO:0006670)7.34413405
6multicellular organismal water homeostasis (GO:0050891)7.20044768
7diol metabolic process (GO:0034311)6.80178426
8regulation of ruffle assembly (GO:1900027)6.13788340
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.07036489
10water homeostasis (GO:0030104)6.04055359
11epidermal cell differentiation (GO:0009913)6.01388585
12regulation of phospholipase A2 activity (GO:0032429)5.96196458
13long-chain fatty acid biosynthetic process (GO:0042759)5.81318305
14regulation of cell proliferation involved in kidney development (GO:1901722)5.61914966
15peptide cross-linking (GO:0018149)5.61806488
16interferon-gamma secretion (GO:0072643)5.44930203
17intermediate filament organization (GO:0045109)5.29616492
18glucosamine-containing compound catabolic process (GO:1901072)5.20396117
19fatty acid elongation (GO:0030497)5.14644898
20positive regulation of interleukin-8 secretion (GO:2000484)5.10355708
21epidermis development (GO:0008544)5.07041184
22regulation of chemokine secretion (GO:0090196)4.98812652
23hair cycle (GO:0042633)4.96926333
24molting cycle (GO:0042303)4.96926333
25regulation of transforming growth factor beta1 production (GO:0032908)4.87515415
26gap junction assembly (GO:0016264)4.87088483
27cyclooxygenase pathway (GO:0019371)4.80684972
28detection of bacterium (GO:0016045)4.78787403
29negative regulation of stress fiber assembly (GO:0051497)4.60178479
30surfactant homeostasis (GO:0043129)4.54153175
31establishment of tissue polarity (GO:0007164)4.53291329
32establishment of planar polarity (GO:0001736)4.53291329
33regulation of hypersensitivity (GO:0002883)4.50304615
34skin morphogenesis (GO:0043589)4.29291890
35polarized epithelial cell differentiation (GO:0030859)4.25895571
36linoleic acid metabolic process (GO:0043651)4.20855902
37phospholipid scrambling (GO:0017121)4.19897274
38lateral sprouting from an epithelium (GO:0060601)4.19519151
39positive regulation of chemokine secretion (GO:0090197)4.18256712
40regulation of interleukin-8 secretion (GO:2000482)4.07746029
41keratinocyte development (GO:0003334)4.07335418
42detection of other organism (GO:0098543)4.06200104
43negative regulation of kidney development (GO:0090185)4.02315176
44positive regulation of glomerulus development (GO:0090193)3.99590714
45phosphatidylinositol acyl-chain remodeling (GO:0036149)3.99163669
46long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.94003083
47viral transcription (GO:0019083)3.80088367
48chemical homeostasis within a tissue (GO:0048875)3.76421810
49G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.76122549
50cardiolipin metabolic process (GO:0032048)3.75243259
51epithelium development (GO:0060429)3.75240600
52hair follicle morphogenesis (GO:0031069)3.75120746
53negative regulation of T cell mediated immunity (GO:0002710)3.74111097
54prostaglandin biosynthetic process (GO:0001516)3.72984056
55prostanoid biosynthetic process (GO:0046457)3.72984056
56ceramide biosynthetic process (GO:0046513)3.70437407
57ectoderm development (GO:0007398)3.62817241
58negative regulation of interleukin-2 production (GO:0032703)3.62658322
59translational termination (GO:0006415)3.55514177
60negative regulation of acute inflammatory response (GO:0002674)3.52473960
61negative regulation of interleukin-17 production (GO:0032700)3.49399839
62regulation of glomerular filtration (GO:0003093)3.48827328
63phosphatidylserine acyl-chain remodeling (GO:0036150)3.47434864
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41761621
65lipoxygenase pathway (GO:0019372)3.40852727
66negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.40752580
67negative regulation of interferon-gamma production (GO:0032689)3.40597774
68positive regulation of monocyte chemotaxis (GO:0090026)3.40007507
69negative regulation of keratinocyte proliferation (GO:0010839)3.36675625
70detection of external biotic stimulus (GO:0098581)3.34025739
71phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.33687991
72positive regulation of interleukin-4 production (GO:0032753)3.33537841
73ribosomal small subunit biogenesis (GO:0042274)3.33166649
74negative regulation of actin filament bundle assembly (GO:0032232)3.32661318
75epithelial cell differentiation involved in prostate gland development (GO:0060742)3.28912437
76positive regulation of cholesterol efflux (GO:0010875)3.28813782
77hemidesmosome assembly (GO:0031581)3.28779524
78sphingolipid biosynthetic process (GO:0030148)3.27712431
79phosphatidylserine metabolic process (GO:0006658)3.26540464
80regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.24681499
81negative regulation of cell fate specification (GO:0009996)3.22359453
82positive regulation of hair follicle development (GO:0051798)3.18856394
83positive regulation of hair cycle (GO:0042635)3.18856394
84phospholipid efflux (GO:0033700)3.18631255
85fatty-acyl-CoA metabolic process (GO:0035337)3.18557876
86regulation of keratinocyte differentiation (GO:0045616)3.18268607
87chemosensory behavior (GO:0007635)3.18109813
88intermediate filament cytoskeleton organization (GO:0045104)3.17382190
89regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.16868451
90primary alcohol catabolic process (GO:0034310)3.09758489
91intermediate filament-based process (GO:0045103)3.08665158
92response to phenylpropanoid (GO:0080184)3.06876136
93atrioventricular valve morphogenesis (GO:0003181)3.05799153
94regulation of glomerulus development (GO:0090192)3.05557809
95phospholipid catabolic process (GO:0009395)3.04513448
96phosphatidylcholine acyl-chain remodeling (GO:0036151)3.02843151
97ventricular cardiac muscle cell action potential (GO:0086005)2.99784146
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.97369713
99gland morphogenesis (GO:0022612)2.96663306
100positive regulation of vesicle fusion (GO:0031340)2.95234779
101prostanoid metabolic process (GO:0006692)2.94580814
102prostaglandin metabolic process (GO:0006693)2.94580814
103positive regulation of T cell chemotaxis (GO:0010820)2.88133307
104regulation of T cell chemotaxis (GO:0010819)2.88133307
105negative regulation of lipase activity (GO:0060192)2.87318273
106positive regulation of epidermis development (GO:0045684)2.86766689
107icosanoid secretion (GO:0032309)2.85723236
108arachidonic acid secretion (GO:0050482)2.85723236
109positive regulation of sterol transport (GO:0032373)2.84867073
110positive regulation of cholesterol transport (GO:0032376)2.84867073
111detection of biotic stimulus (GO:0009595)2.84766882
112cardiac right ventricle morphogenesis (GO:0003215)2.84218873
113renal system process involved in regulation of blood volume (GO:0001977)2.81997332
114viral life cycle (GO:0019058)2.79979185
115regulation of keratinocyte proliferation (GO:0010837)2.78287577
116SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77666046
117regulation of natural killer cell differentiation (GO:0032823)2.77578487
118unsaturated fatty acid biosynthetic process (GO:0006636)2.76183848
119protein targeting to ER (GO:0045047)2.74170109
120sequestering of metal ion (GO:0051238)2.73607584
121cotranslational protein targeting to membrane (GO:0006613)2.72629541
122intestinal epithelial cell development (GO:0060576)2.71504277
123eyelid development in camera-type eye (GO:0061029)2.71163464
124hair cycle process (GO:0022405)2.71079519
125molting cycle process (GO:0022404)2.71079519
126regulation of neuron projection regeneration (GO:0070570)2.70902682
127regulation of axon regeneration (GO:0048679)2.70902682
128defense response to fungus (GO:0050832)2.70665409
129establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70321778
130regulation of protein localization to cell surface (GO:2000008)2.70014045
131regulation of heart rate by cardiac conduction (GO:0086091)2.65302921
132alditol phosphate metabolic process (GO:0052646)2.63651746
133regulation of natural killer cell activation (GO:0032814)2.60502152
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55962114
135one-carbon compound transport (GO:0019755)2.55111805
136epithelial cell differentiation (GO:0030855)2.46495198
137regulation of monocyte chemotaxis (GO:0090025)2.43168509
138regulation of cholesterol efflux (GO:0010874)2.38970304
139cell communication involved in cardiac conduction (GO:0086065)2.38077252
140positive regulation of epidermal cell differentiation (GO:0045606)2.37877834
141regulation of epidermis development (GO:0045682)2.37593831
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37260202
143regulation of epidermal cell differentiation (GO:0045604)2.28650160
144polyol transport (GO:0015791)2.27052023
145sympathetic nervous system development (GO:0048485)2.26416355
146positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.23829744
147defense response to Gram-negative bacterium (GO:0050829)2.22882745
148negative regulation of epidermal cell differentiation (GO:0045605)2.16077204
149antimicrobial humoral response (GO:0019730)2.15870846
150cardiac conduction (GO:0061337)2.14664441
151genitalia morphogenesis (GO:0035112)2.13684376
152skin development (GO:0043588)2.12226710
153phosphatidylglycerol metabolic process (GO:0046471)2.10606500
154cardiac muscle cell action potential involved in contraction (GO:0086002)2.09549008
155epithelial cell proliferation (GO:0050673)2.06236236
156hair cell differentiation (GO:0035315)2.05833261
157cardiac muscle cell action potential (GO:0086001)2.02913335
158desmosome organization (GO:0002934)16.2675384
159establishment of skin barrier (GO:0061436)11.5324197
160regulation of water loss via skin (GO:0033561)10.6091883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.87614736
2P63_26484246_Chip-Seq_KERATINOCYTES_Human2.95388821
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.77388178
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.25731544
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.18414398
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14825733
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.08670742
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07217511
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03409226
10TP63_17297297_ChIP-ChIP_HaCaT_Human14.4952296
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98642343
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.96556047
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.87520908
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.83514768
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.83514768
16TCF4_18268006_ChIP-ChIP_LS174T_Human1.75866394
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70562980
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63750762
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.61297727
20SOX2_20726797_ChIP-Seq_SW620_Human1.59970364
21TP63_23658742_ChIP-Seq_EP156T_Human1.50721020
22ERG_20517297_ChIP-Seq_VCAP_Human1.43884687
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.42622572
24BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.40815605
25TP53_18474530_ChIP-ChIP_U2OS_Human1.36524595
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33952990
27ZNF263_19887448_ChIP-Seq_K562_Human1.29341457
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29160226
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25621808
30CJUN_26792858_Chip-Seq_BT549_Human1.24527261
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.22070172
32GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.21144704
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.21134020
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18014534
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.17640975
36AR_21572438_ChIP-Seq_LNCaP_Human1.16841403
37TP63_22573176_ChIP-Seq_HFKS_Human1.15794018
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14684435
39KLF5_25053715_ChIP-Seq_YYC3_Human1.14298431
40GATA4_25053715_ChIP-Seq_YYC3_Human1.13713079
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12141208
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.09667084
43RXR_22108803_ChIP-Seq_LS180_Human1.09001710
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07590786
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07590786
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07025622
47GATA1_22025678_ChIP-Seq_K562_Human1.05038886
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04850375
49GATA6_21074721_ChIP-Seq_CACO-2_Human1.03056208
50CDX2_20551321_ChIP-Seq_CACO-2_Human0.99036265
51AHR_22903824_ChIP-Seq_MCF-7_Human0.98716723
52GATA3_24758297_ChIP-Seq_MCF-7_Human0.98539850
53CTCF_20526341_ChIP-Seq_ESCs_Human0.98493990
54TAF2_19829295_ChIP-Seq_ESCs_Human0.98325705
55TCF4_22108803_ChIP-Seq_LS180_Human0.97803405
56SMAD4_21799915_ChIP-Seq_A2780_Human0.95228425
57EZH2_27294783_Chip-Seq_ESCs_Mouse0.95195575
58AR_25329375_ChIP-Seq_VCAP_Human0.95071060
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94787257
60BCAT_22108803_ChIP-Seq_LS180_Human0.93826455
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93253488
62P53_21459846_ChIP-Seq_SAOS-2_Human0.92084340
63JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90351413
64CEBPB_22108803_ChIP-Seq_LS180_Human0.89690122
65CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89637178
66E2F1_20622854_ChIP-Seq_HELA_Human0.89597984
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88979276
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88908386
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88365087
70BCOR_27268052_Chip-Seq_Bcells_Human0.87979155
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87257173
72JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87090985
73HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86377887
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86217286
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85493408
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85396701
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85395126
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85395126
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84906494
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84812649
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84675299
82FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84399036
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83825048
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83758397
85P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83375047
86DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82959117
87EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82393975
88RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82393975
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81875179
90GATA2_19941826_ChIP-Seq_K562_Human0.81730410
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.80904934
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.80744973
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.80454237
94NCOR_22424771_ChIP-Seq_293T_Human0.79319017
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.79126395
96MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.78499178
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78333183
98NANOG_20526341_ChIP-Seq_ESCs_Human0.77641196
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77441278
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.77333156
101CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.76801790
102SMAD4_21741376_ChIP-Seq_ESCs_Human0.76376578
103RBPJ_21746931_ChIP-Seq_IB4_Human0.76073337
104RNF2_27304074_Chip-Seq_NSC_Mouse0.75762649
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75719124
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.75379698
107SMC4_20622854_ChIP-Seq_HELA_Human0.75288937
108ATF3_27146783_Chip-Seq_COLON_Human0.75287623
109RACK7_27058665_Chip-Seq_MCF-7_Human0.74987939
110TP53_16413492_ChIP-PET_HCT116_Human0.74690515
111P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74142372
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73876635
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.73876635
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.72733827
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72674629
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72654603
117HNFA_21074721_ChIP-Seq_CACO-2_Human0.72483616
118GATA3_21878914_ChIP-Seq_MCF-7_Human0.72026803
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71248827
120GATA6_25053715_ChIP-Seq_YYC3_Human0.71198108
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.71095710
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70936174
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70928164
124SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.70620052
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.70335364
126VDR_22108803_ChIP-Seq_LS180_Human0.69597828
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.68578210
128SA1_27219007_Chip-Seq_Bcells_Human0.68255545
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.67971620
130UBF1/2_26484160_Chip-Seq_HMECs_Human0.67861530
131CBX2_22325352_ChIP-Seq_293T-Rex_Human0.67340765
132CTCF_27219007_Chip-Seq_Bcells_Human0.67072031
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.66684674
134PHF8_20622853_ChIP-Seq_HELA_Human0.66046465
135HTT_18923047_ChIP-ChIP_STHdh_Human0.64814992
136LXR_22292898_ChIP-Seq_THP-1_Human0.64646344
137MTF2_20144788_ChIP-Seq_MESCs_Mouse0.63660443
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.63629602
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.63258673
140EGR1_19032775_ChIP-ChIP_M12_Human0.62841443
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.62778861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.95958869
2MP0010234_abnormal_vibrissa_follicle6.52919702
3MP0003941_abnormal_skin_development6.17325174
4MP0005501_abnormal_skin_physiology5.05915274
5MP0004381_abnormal_hair_follicle4.95957471
6MP0005275_abnormal_skin_tensile4.90526050
7MP0001216_abnormal_epidermal_layer3.34813485
8MP0002098_abnormal_vibrissa_morphology3.31825261
9MP0002060_abnormal_skin_morphology3.25298088
10MP0000566_synostosis3.22433283
11MP0000579_abnormal_nail_morphology3.14013815
12MP0005451_abnormal_body_composition3.13962126
13MP0003453_abnormal_keratinocyte_physiol3.13699830
14MP0010771_integument_phenotype3.08379704
15MP0010678_abnormal_skin_adnexa3.02337144
16MP0005377_hearing/vestibular/ear_phenot2.78692912
17MP0003878_abnormal_ear_physiology2.78692912
18MP0000383_abnormal_hair_follicle2.70679957
19MP0000647_abnormal_sebaceous_gland2.62599877
20MP0000377_abnormal_hair_follicle2.54770410
21MP0004885_abnormal_endolymph2.43642753
22MP0002009_preneoplasia2.43457839
23MP0001188_hyperpigmentation2.36353639
24MP0004947_skin_inflammation2.26266830
25MP0000467_abnormal_esophagus_morphology2.17235540
26MP0000427_abnormal_hair_cycle2.00547488
27MP0002254_reproductive_system_inflammat1.72397018
28MP0009931_abnormal_skin_appearance1.61490532
29MP0000762_abnormal_tongue_morphology1.60886729
30MP0001191_abnormal_skin_condition1.60750445
31MP0003566_abnormal_cell_adhesion1.55456054
32MP0001346_abnormal_lacrimal_gland1.41604124
33MP0003011_delayed_dark_adaptation1.41581450
34MP0009379_abnormal_foot_pigmentation1.41357069
35MP0008004_abnormal_stomach_pH1.40215603
36MP0000367_abnormal_coat/_hair1.39962184
37MP0001243_abnormal_dermal_layer1.31879506
38MP0004185_abnormal_adipocyte_glucose1.28686646
39MP0003136_yellow_coat_color1.22318876
40MP0005075_abnormal_melanosome_morpholog1.12887868
41MP0003705_abnormal_hypodermis_morpholog1.12140393
42MP0003315_abnormal_perineum_morphology1.05484090
43MP0001851_eye_inflammation1.03810593
44MP0001984_abnormal_olfaction1.00255551
45MP0001340_abnormal_eyelid_morphology0.96553391
46MP0003191_abnormal_cellular_cholesterol0.94154706
47MP0004782_abnormal_surfactant_physiolog0.93560345
48MP0010352_gastrointestinal_tract_polyps0.88916281
49MP0002234_abnormal_pharynx_morphology0.87466127
50MP0010386_abnormal_urinary_bladder0.87422065
51MP0000465_gastrointestinal_hemorrhage0.83110735
52MP0000015_abnormal_ear_pigmentation0.81102455
53MP0000516_abnormal_urinary_system0.80704136
54MP0005367_renal/urinary_system_phenotyp0.80704136
55MP0002006_tumorigenesis0.78480818
56MP0002277_abnormal_respiratory_mucosa0.77809723
57MP0009053_abnormal_anal_canal0.73605850
58MP0005174_abnormal_tail_pigmentation0.72489900
59MP0002249_abnormal_larynx_morphology0.71968279
60MP0002166_altered_tumor_susceptibility0.66620314
61MP0004019_abnormal_vitamin_homeostasis0.66164942
62MP0000627_abnormal_mammary_gland0.62978823
63MP0005076_abnormal_cell_differentiation0.58025160
64MP0002177_abnormal_outer_ear0.55889744
65MP0002148_abnormal_hypersensitivity_rea0.55358371
66MP0000537_abnormal_urethra_morphology0.53822819
67MP0003436_decreased_susceptibility_to0.53816387
68MP0005508_abnormal_skeleton_morphology0.52012566
69MP0002138_abnormal_hepatobiliary_system0.50288745
70MP0001784_abnormal_fluid_regulation0.49938003
71MP0003950_abnormal_plasma_membrane0.49722996
72MP0005503_abnormal_tendon_morphology0.49351704
73MP0004264_abnormal_extraembryonic_tissu0.48972575
74MP0002132_abnormal_respiratory_system0.48820401
75MP0008789_abnormal_olfactory_epithelium0.48344585
76MP0003755_abnormal_palate_morphology0.47043105
77MP0009384_cardiac_valve_regurgitation0.45483257
78MP0003638_abnormal_response/metabolism_0.44919566
79MP0001485_abnormal_pinna_reflex0.44917415
80MP0005023_abnormal_wound_healing0.44693392
81MP0003763_abnormal_thymus_physiology0.41700795
82MP0002090_abnormal_vision0.40329871
83MP0005187_abnormal_penis_morphology0.39852343
84MP0005499_abnormal_olfactory_system0.39305394
85MP0005394_taste/olfaction_phenotype0.39305394
86MP0002877_abnormal_melanocyte_morpholog0.38990580
87MP0009780_abnormal_chondrocyte_physiolo0.33542078
88MP0006054_spinal_hemorrhage0.33181927
89MP0002111_abnormal_tail_morphology0.32670106
90MP0002233_abnormal_nose_morphology0.32438707
91MP0002282_abnormal_trachea_morphology0.31525864
92MP0000538_abnormal_urinary_bladder0.29507258
93MP0004197_abnormal_fetal_growth/weight/0.28588322
94MP0001542_abnormal_bone_strength0.28352021
95MP0009250_abnormal_appendicular_skeleto0.28327501
96MP0005390_skeleton_phenotype0.28198836
97MP0003938_abnormal_ear_development0.28063613
98MP0000470_abnormal_stomach_morphology0.27273467
99MP0005647_abnormal_sex_gland0.26963022
100MP0005388_respiratory_system_phenotype0.26641702
101MP0002133_abnormal_respiratory_system0.26641702
102MP0010030_abnormal_orbit_morphology0.24561819
103MP0000613_abnormal_salivary_gland0.24559835
104MP0009672_abnormal_birth_weight0.23619654
105MP0003936_abnormal_reproductive_system0.23091708
106MP0001177_atelectasis0.22981177
107MP0005666_abnormal_adipose_tissue0.22208767
108MP0002095_abnormal_skin_pigmentation0.21740557
109MP0005409_darkened_coat_color0.20622948
110MP0005248_abnormal_Harderian_gland0.20370871
111MP0005410_abnormal_fertilization0.19727972
112MP0005375_adipose_tissue_phenotype0.18527012
113MP0003718_maternal_effect0.18512698
114MP0000569_abnormal_digit_pigmentation0.18176725
115MP0000432_abnormal_head_morphology0.17774277
116MP0003385_abnormal_body_wall0.17744364
117MP0000372_irregular_coat_pigmentation0.17675868
118MP0002697_abnormal_eye_size0.17364823
119MP0004272_abnormal_basement_membrane0.16559416
120MP0002109_abnormal_limb_morphology0.15563075
121MP0000428_abnormal_craniofacial_morphol0.15027110
122MP0000003_abnormal_adipose_tissue0.14937001
123MP0009115_abnormal_fat_cell0.12868384
124MP0004043_abnormal_pH_regulation0.07514966
125MP0003300_gastrointestinal_ulcer0.07393542
126MP0001186_pigmentation_phenotype0.07182997
127MP0005193_abnormal_anterior_eye0.07104199
128MP0009703_decreased_birth_body0.06657567
129MP0001286_abnormal_eye_development0.06379895
130MP0002081_perinatal_lethality0.06227985
131MP0006138_congestive_heart_failure0.05833002
132MP0008569_lethality_at_weaning0.05815946
133MP0009333_abnormal_splenocyte_physiolog0.05122732
134MP0008438_abnormal_cutaneous_collagen0.03804253

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.77441133
2Parakeratosis (HP:0001036)8.20731112
3Congenital ichthyosiform erythroderma (HP:0007431)7.94065581
4Hypotrichosis (HP:0001006)7.36806575
5Increased IgE level (HP:0003212)7.02727381
6Lip pit (HP:0100267)6.57141405
7Erythema (HP:0010783)6.05625631
8Woolly hair (HP:0002224)6.04673174
9Abnormality of nail color (HP:0100643)5.99670543
10Right ventricular cardiomyopathy (HP:0011663)5.94822623
11Erythroderma (HP:0001019)5.69078069
12Palmoplantar hyperkeratosis (HP:0000972)5.38742024
13Palmar hyperkeratosis (HP:0010765)5.06279425
14Plantar hyperkeratosis (HP:0007556)5.04274262
15Popliteal pterygium (HP:0009756)4.84583170
16Natal tooth (HP:0000695)4.74352110
17Oral leukoplakia (HP:0002745)4.68568398
18Abnormality of secondary sexual hair (HP:0009888)4.46569927
19Abnormality of the axillary hair (HP:0100134)4.46569927
20Sparse scalp hair (HP:0002209)4.25436082
21Absent eyelashes (HP:0000561)4.24998609
22Ectropion (HP:0000656)4.10525117
23Corneal erosion (HP:0200020)3.94533837
24Onycholysis (HP:0001806)3.92471163
25Sparse eyelashes (HP:0000653)3.81163920
26Hypohidrosis (HP:0000966)3.80095483
27Advanced eruption of teeth (HP:0006288)3.79859609
28Abnormal blistering of the skin (HP:0008066)3.56223445
29Gangrene (HP:0100758)3.47647243
30Acanthosis nigricans (HP:0000956)3.44973862
31Pruritus (HP:0000989)3.44065569
32Hypoplastic labia majora (HP:0000059)3.39187224
33Fragile nails (HP:0001808)3.39130905
34Slow-growing hair (HP:0002217)3.32202611
35Abnormality of hair growth rate (HP:0011363)3.32202611
36Oligodontia (HP:0000677)3.27378693
37Abnormality of the salivary glands (HP:0010286)3.15995941
38Palmoplantar keratoderma (HP:0000982)3.10526591
39Abnormality of the labia majora (HP:0012881)3.07514791
40Ventricular tachycardia (HP:0004756)3.01241334
41Curly hair (HP:0002212)2.99152312
42Conjunctival hamartoma (HP:0100780)2.95897154
43Concave nail (HP:0001598)2.79349002
44Dry hair (HP:0011359)2.75774932
45Furrowed tongue (HP:0000221)2.75762692
46Nail dystrophy (HP:0008404)2.74615196
47Hyporeflexia of lower limbs (HP:0002600)2.70764016
48Distal lower limb muscle weakness (HP:0009053)2.68792606
49Dry skin (HP:0000958)2.67600136
50Reticulocytopenia (HP:0001896)2.64613384
51Brittle hair (HP:0002299)2.60686953
52Anhidrosis (HP:0000970)2.54450782
53Pterygium (HP:0001059)2.54141676
54Pili torti (HP:0003777)2.53389738
55Congenital, generalized hypertrichosis (HP:0004540)2.52217295
56Abnormality of placental membranes (HP:0011409)2.38660685
57Amniotic constriction ring (HP:0009775)2.38660685
58Septate vagina (HP:0001153)2.38229420
59Autoamputation (HP:0001218)2.33115551
60Eczematoid dermatitis (HP:0000976)2.31019857
61Hypergammaglobulinemia (HP:0010702)2.27156076
62Abnormality of cells of the erythroid lineage (HP:0012130)2.23136946
63Thick nail (HP:0001805)2.21519266
64Dehydration (HP:0001944)2.20469651
65Ventricular fibrillation (HP:0001663)2.20393412
66Abnormality of the gastric mucosa (HP:0004295)2.20017594
67Corneal dystrophy (HP:0001131)2.19546513
68Split foot (HP:0001839)2.19294878
69Pustule (HP:0200039)2.19210397
70Labial hypoplasia (HP:0000066)2.17574750
71Epidermoid cyst (HP:0200040)2.15228851
72Duplicated collecting system (HP:0000081)2.11665420
73Villous atrophy (HP:0011473)2.11623985
74Abnormality of small intestinal villus morphology (HP:0011472)2.11623985
75Selective tooth agenesis (HP:0001592)2.11300878
76Fine hair (HP:0002213)2.10904844
77Hypoplasia of the uterus (HP:0000013)2.08643970
78Absent eyebrow (HP:0002223)2.08116924
79Melanocytic nevus (HP:0000995)2.07959578
80Bifid scrotum (HP:0000048)2.05577696
81Severe Myopia (HP:0011003)2.05134750
82Ulnar claw (HP:0001178)2.03316257
83Abnormal hemoglobin (HP:0011902)2.03146452
84Depressed nasal tip (HP:0000437)2.02171710
85Skin pits (HP:0100276)2.00197969
86Areflexia of lower limbs (HP:0002522)1.97721638
87Hypoplastic female external genitalia (HP:0012815)1.97576541
88Paralysis (HP:0003470)1.96608419
89Follicular hyperkeratosis (HP:0007502)1.94331358
90Abnormality of the dental root (HP:0006486)1.88177705
91Taurodontia (HP:0000679)1.88177705
92Abnormality of permanent molar morphology (HP:0011071)1.88177705
93Conical tooth (HP:0000698)1.86981228
94Hypodontia (HP:0000668)1.86903904
95Recurrent corneal erosions (HP:0000495)1.85470410
96Milia (HP:0001056)1.84560831
97Abnormal number of erythroid precursors (HP:0012131)1.82697633
98Lack of skin elasticity (HP:0100679)1.82477761
99Aplasia/hypoplasia of the uterus (HP:0008684)1.81968548
100Abnormality of the renal collecting system (HP:0004742)1.81895450
101Abnormality of molar morphology (HP:0011070)1.77992855
102Abnormality of molar (HP:0011077)1.77992855
103Blepharitis (HP:0000498)1.77680414
104Hypoparathyroidism (HP:0000829)1.76578381
105Nasolacrimal duct obstruction (HP:0000579)1.75768756
106Multifactorial inheritance (HP:0001426)1.75429910
107Hamartoma (HP:0010566)1.75379188
108Hypoplasia of dental enamel (HP:0006297)1.74040291
109Urticaria (HP:0001025)1.70911599
110Ridged nail (HP:0001807)1.70445743
111Abnormality of the dental pulp (HP:0006479)1.70264465
112Laryngomalacia (HP:0001601)1.70249213
113Macrocytic anemia (HP:0001972)1.70200284
114Premature ovarian failure (HP:0008209)1.67480715
115Abnormality of the labia (HP:0000058)1.64206729
116Keratoconjunctivitis sicca (HP:0001097)1.63361616
117Hyperhidrosis (HP:0000975)1.63190152
118Xerostomia (HP:0000217)1.62053659
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.61040202
120Abnormality of the fetal cardiovascular system (HP:0010948)1.60403376
121Abnormal umbilical cord blood vessels (HP:0011403)1.60403376
122Single umbilical artery (HP:0001195)1.60403376
123Absent hair (HP:0002298)1.59387661
124Down-sloping shoulders (HP:0200021)1.58263920
125Breast hypoplasia (HP:0003187)1.55783075
126Alopecia of scalp (HP:0002293)1.54730066
127Hamartoma of the eye (HP:0010568)1.54526394
128Aplasia involving bones of the extremities (HP:0009825)1.53277591
129Aplasia involving bones of the upper limbs (HP:0009823)1.53277591
130Aplasia of the phalanges of the hand (HP:0009802)1.53277591
131Sepsis (HP:0100806)1.52835594
132Abnormal hair laboratory examination (HP:0003328)1.52484021
133Neonatal death (HP:0003811)1.51747778
134Malignant hyperthermia (HP:0002047)1.51385578
135Keratoconjunctivitis (HP:0001096)1.50319297
136Type I diabetes mellitus (HP:0100651)1.49168494
137Skin ulcer (HP:0200042)1.47818043
138Anonychia (HP:0001798)1.46956811
139Carious teeth (HP:0000670)1.45700727
140Abnormality of the lacrimal duct (HP:0011481)1.41227203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR16.34007519
2MST45.33083518
3MAPKAPK34.51631915
4MAP3K34.16076360
5MST1R3.66580472
6FER3.66175749
7MAP3K23.39170322
8EPHB22.99537548
9PIM22.94712141
10FGFR12.71878986
11TRPM72.52075210
12RPS6KB22.42406718
13WNK12.24891382
14ERBB31.98394125
15MAPKAPK51.94356059
16MAP3K91.93492100
17BCR1.92696636
18TESK11.87184066
19AKT31.81301095
20SGK4941.80468063
21SGK2231.80468063
22RIPK41.78093377
23GRK11.76684818
24LATS11.68735733
25STK101.68466431
26TNK21.67977545
27MAP3K141.65369559
28SGK21.54991810
29MAPK71.54160723
30BLK1.44500404
31STK241.43498141
32FRK1.39694000
33STK31.38114520
34LRRK21.33589483
35NTRK21.29478879
36DYRK1B1.23658945
37STK38L1.20918452
38CASK1.20646026
39GRK61.18817130
40PIK3CG1.13967724
41FGFR41.12955605
42EPHA41.11454747
43LIMK11.10831604
44GRK71.10803695
45CDK31.10544487
46CDK121.07944339
47RPS6KB11.07401929
48EPHA31.07401860
49SGK31.06645270
50ITK1.03382405
51MET1.01294742
52FGFR20.97917734
53RIPK10.95379585
54MAP4K20.93874957
55PTK60.91234655
56IRAK10.89315189
57IRAK30.88538291
58MARK10.88090873
59BRD40.88055022
60TNIK0.86691156
61TGFBR20.84754472
62MAP2K60.83313487
63EPHA20.81749704
64STK380.80677422
65CAMK1G0.80627367
66EIF2AK20.79856274
67BMPR1B0.75971070
68PRKCE0.75001098
69MAPKAPK20.74034696
70PRKAA20.73219635
71FGFR30.72862853
72EEF2K0.70280537
73PTK20.68226755
74ADRBK10.67589962
75CAMK1D0.65327729
76CDK190.64651217
77MINK10.64421433
78MAP3K70.64337339
79MTOR0.63512373
80INSRR0.62151748
81SYK0.62044468
82YES10.61993019
83NLK0.61011575
84MAPK150.59244561
85DDR20.57880836
86BRAF0.57869806
87PKN10.57664779
88TAOK10.57149489
89ERN10.56433420
90SGK10.54462016
91CSNK1D0.54326064
92MAP2K40.53119610
93MAP3K60.53084379
94IKBKB0.52635670
95PBK0.50984957
96CDK60.48554345
97ROCK10.48369778
98MAP3K10.47916864
99BMPR20.47835950
100GRK50.44333364
101EPHB10.44106381
102TAOK30.43697118
103TEC0.43467218
104RPS6KA10.42924332
105PRKD10.42600236
106RPS6KA20.41928723
107HIPK20.41864339
108SRPK10.41275844
109HCK0.39381749
110ACVR1B0.37628527
111TXK0.37583897
112MAP3K110.37398392
113LATS20.37130699
114MAPK90.37113516
115IKBKE0.36656798
116MUSK0.36217896
117MAP2K10.35806691
118PRKCI0.34840537
119ABL10.33194146
120TYRO30.33159195
121ERBB20.32746739
122DMPK0.32462550
123MAP3K50.30448871
124PDK20.29940297
125ERBB40.29037367
126PRKCA0.28694653
127DYRK1A0.28600418
128AURKA0.28063972
129MAPK10.27532196
130PIK3CA0.27077136
131SRC0.26802515
132PRKD20.26666336
133MAPK40.26407654
134CHUK0.25110401
135RET0.25037798
136NME20.24820362
137MAPK80.24595826
138KIT0.23293877
139PAK30.22335074
140BTK0.21837040
141OBSCN0.21669567
142JAK20.20841214
143PDGFRB0.20795987
144MAPK120.20709009
145TYK20.20194628
146MARK20.20107761
147DYRK30.19814498
148MAP3K120.19445020

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006004.78563381
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.56964998
3Linoleic acid metabolism_Homo sapiens_hsa005913.32754133
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.23383847
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.23333518
6Arachidonic acid metabolism_Homo sapiens_hsa005903.21080054
7Ribosome_Homo sapiens_hsa030103.17951445
8Fatty acid elongation_Homo sapiens_hsa000622.77616377
9Phenylalanine metabolism_Homo sapiens_hsa003602.29559708
10Histidine metabolism_Homo sapiens_hsa003402.28316174
11Ether lipid metabolism_Homo sapiens_hsa005652.14966580
12Retinol metabolism_Homo sapiens_hsa008301.85379296
13Circadian rhythm_Homo sapiens_hsa047101.76972603
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69302379
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.66074158
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63385622
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58427882
18Dorso-ventral axis formation_Homo sapiens_hsa043201.48870934
19Collecting duct acid secretion_Homo sapiens_hsa049661.46460961
20Sphingolipid signaling pathway_Homo sapiens_hsa040711.41678819
21Chemical carcinogenesis_Homo sapiens_hsa052041.40540189
22Choline metabolism in cancer_Homo sapiens_hsa052311.39912531
23Tight junction_Homo sapiens_hsa045301.23399966
24Tyrosine metabolism_Homo sapiens_hsa003501.22653573
25Serotonergic synapse_Homo sapiens_hsa047261.21960667
26Basal cell carcinoma_Homo sapiens_hsa052171.21117964
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20333464
28Phototransduction_Homo sapiens_hsa047441.17813110
29Amoebiasis_Homo sapiens_hsa051461.16212022
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13546966
31Axon guidance_Homo sapiens_hsa043601.12206636
32Adherens junction_Homo sapiens_hsa045201.10655457
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09133609
34p53 signaling pathway_Homo sapiens_hsa041151.05800904
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05251862
36VEGF signaling pathway_Homo sapiens_hsa043701.01464050
37ABC transporters_Homo sapiens_hsa020100.99750994
38Renin secretion_Homo sapiens_hsa049240.98386556
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95750660
40Glioma_Homo sapiens_hsa052140.95658424
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95116697
42Staphylococcus aureus infection_Homo sapiens_hsa051500.94831459
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93020704
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.91403119
45Pancreatic secretion_Homo sapiens_hsa049720.84654344
46Mineral absorption_Homo sapiens_hsa049780.83758116
47Melanogenesis_Homo sapiens_hsa049160.83476348
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82898505
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.82644254
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82247939
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81994139
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81641101
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80294635
54Acute myeloid leukemia_Homo sapiens_hsa052210.79559334
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77661664
56Steroid biosynthesis_Homo sapiens_hsa001000.77608684
57Hepatitis C_Homo sapiens_hsa051600.75346926
58Ras signaling pathway_Homo sapiens_hsa040140.74562998
59GnRH signaling pathway_Homo sapiens_hsa049120.74079978
60Hippo signaling pathway_Homo sapiens_hsa043900.73603412
61Fat digestion and absorption_Homo sapiens_hsa049750.73348673
62Pertussis_Homo sapiens_hsa051330.70780671
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.69404795
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.67585633
65beta-Alanine metabolism_Homo sapiens_hsa004100.66492284
66Glutathione metabolism_Homo sapiens_hsa004800.65370970
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.65230111
68Thyroid cancer_Homo sapiens_hsa052160.64862474
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62794572
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61805270
71TGF-beta signaling pathway_Homo sapiens_hsa043500.61681829
72Vibrio cholerae infection_Homo sapiens_hsa051100.60335820
73Fatty acid biosynthesis_Homo sapiens_hsa000610.60161940
74Bladder cancer_Homo sapiens_hsa052190.59309992
75Circadian entrainment_Homo sapiens_hsa047130.58953058
76cAMP signaling pathway_Homo sapiens_hsa040240.58371467
77PPAR signaling pathway_Homo sapiens_hsa033200.58257752
78Endocytosis_Homo sapiens_hsa041440.57008878
79Olfactory transduction_Homo sapiens_hsa047400.56336611
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.56130798
81MAPK signaling pathway_Homo sapiens_hsa040100.55056025
82Proteoglycans in cancer_Homo sapiens_hsa052050.54103509
83MicroRNAs in cancer_Homo sapiens_hsa052060.53747718
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53421028
85Ovarian steroidogenesis_Homo sapiens_hsa049130.52393215
86Gastric acid secretion_Homo sapiens_hsa049710.52368572
87Long-term depression_Homo sapiens_hsa047300.52193195
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51849515
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51199775
90Platelet activation_Homo sapiens_hsa046110.50823656
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.49719839
92Arginine biosynthesis_Homo sapiens_hsa002200.48659815
93Folate biosynthesis_Homo sapiens_hsa007900.48636030
94ErbB signaling pathway_Homo sapiens_hsa040120.48370793
95ECM-receptor interaction_Homo sapiens_hsa045120.47983299
96Caffeine metabolism_Homo sapiens_hsa002320.47856651
97Graft-versus-host disease_Homo sapiens_hsa053320.45401119
98Vitamin digestion and absorption_Homo sapiens_hsa049770.45220979
99Melanoma_Homo sapiens_hsa052180.44877184
100Glycerolipid metabolism_Homo sapiens_hsa005610.44193158
101Hedgehog signaling pathway_Homo sapiens_hsa043400.44165372
102Rheumatoid arthritis_Homo sapiens_hsa053230.44117417
103Wnt signaling pathway_Homo sapiens_hsa043100.43554694
104Calcium signaling pathway_Homo sapiens_hsa040200.42538649
105Insulin signaling pathway_Homo sapiens_hsa049100.39947499
106Renal cell carcinoma_Homo sapiens_hsa052110.38769797
107Rap1 signaling pathway_Homo sapiens_hsa040150.37125903
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36770627
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36087801
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35919773
111Dopaminergic synapse_Homo sapiens_hsa047280.35780013
112Taste transduction_Homo sapiens_hsa047420.35477452
113Gap junction_Homo sapiens_hsa045400.34919606
114Glutamatergic synapse_Homo sapiens_hsa047240.34818979
115Salivary secretion_Homo sapiens_hsa049700.34577145
116Glucagon signaling pathway_Homo sapiens_hsa049220.33245348
117Renin-angiotensin system_Homo sapiens_hsa046140.31695363
118Pathways in cancer_Homo sapiens_hsa052000.31489597
119Oxytocin signaling pathway_Homo sapiens_hsa049210.29663188
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28202518
121Nitrogen metabolism_Homo sapiens_hsa009100.27450334
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27242561
123Tuberculosis_Homo sapiens_hsa051520.26874579
124Phagosome_Homo sapiens_hsa041450.26622202
125Inositol phosphate metabolism_Homo sapiens_hsa005620.25050109
126T cell receptor signaling pathway_Homo sapiens_hsa046600.24667107
127Amphetamine addiction_Homo sapiens_hsa050310.21259544
128Notch signaling pathway_Homo sapiens_hsa043300.20370144
129Salmonella infection_Homo sapiens_hsa051320.20329931
130Hematopoietic cell lineage_Homo sapiens_hsa046400.20235724
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20121676
132Estrogen signaling pathway_Homo sapiens_hsa049150.19978792
133Long-term potentiation_Homo sapiens_hsa047200.18982705

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