LY6H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.73319173
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.59365046
3locomotory exploration behavior (GO:0035641)6.08934065
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.66843997
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.63375643
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60909906
7vocalization behavior (GO:0071625)5.49329714
8synaptic vesicle exocytosis (GO:0016079)5.39310457
9regulation of synaptic vesicle exocytosis (GO:2000300)5.25391051
10regulation of glutamate receptor signaling pathway (GO:1900449)5.22727397
11glutamate secretion (GO:0014047)5.20069633
12layer formation in cerebral cortex (GO:0021819)5.08694737
13protein localization to synapse (GO:0035418)5.08173938
14exploration behavior (GO:0035640)4.89883999
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.80943900
16neuron cell-cell adhesion (GO:0007158)4.74646326
17regulation of synaptic vesicle transport (GO:1902803)4.69602376
18regulation of synapse structural plasticity (GO:0051823)4.67110630
19regulation of neuronal synaptic plasticity (GO:0048168)4.61114500
20neurotransmitter secretion (GO:0007269)4.57381143
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.56191069
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.48533961
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.47908431
24dendritic spine morphogenesis (GO:0060997)4.36671207
25establishment of mitochondrion localization (GO:0051654)4.30465055
26proline transport (GO:0015824)4.27155165
27neurotransmitter-gated ion channel clustering (GO:0072578)4.17509649
28positive regulation of synaptic transmission, GABAergic (GO:0032230)4.08109050
29synaptic transmission, glutamatergic (GO:0035249)4.06052556
30cerebellar granule cell differentiation (GO:0021707)4.03035909
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02430934
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.97510388
33neuron recognition (GO:0008038)3.94942079
34regulation of voltage-gated calcium channel activity (GO:1901385)3.92599976
35gamma-aminobutyric acid transport (GO:0015812)3.92199203
36activation of protein kinase A activity (GO:0034199)3.90481302
37glutamate receptor signaling pathway (GO:0007215)3.86337371
38positive regulation of membrane potential (GO:0045838)3.85586931
39postsynaptic membrane organization (GO:0001941)3.84483116
40axonal fasciculation (GO:0007413)3.83342886
41L-amino acid import (GO:0043092)3.78186087
42long-term memory (GO:0007616)3.72749297
43clathrin coat assembly (GO:0048268)3.70286820
44dendrite morphogenesis (GO:0048813)3.69746527
45neuronal action potential propagation (GO:0019227)3.68475327
46positive regulation of synapse maturation (GO:0090129)3.67903216
47presynaptic membrane assembly (GO:0097105)3.64001969
48neuron-neuron synaptic transmission (GO:0007270)3.63534144
49regulation of synapse maturation (GO:0090128)3.62539295
50nucleobase catabolic process (GO:0046113)3.62379169
51neurotransmitter transport (GO:0006836)3.58173049
52neuromuscular process controlling balance (GO:0050885)3.57316917
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56996388
54cell migration in hindbrain (GO:0021535)3.55663113
55cell communication by electrical coupling (GO:0010644)3.54382523
56amino acid import (GO:0043090)3.53085595
57presynaptic membrane organization (GO:0097090)3.52629643
58regulation of dendritic spine morphogenesis (GO:0061001)3.51978177
59pyrimidine nucleobase catabolic process (GO:0006208)3.51079476
60potassium ion homeostasis (GO:0055075)3.51012637
61auditory behavior (GO:0031223)3.50056411
62cellular potassium ion homeostasis (GO:0030007)3.50044498
63synaptic vesicle endocytosis (GO:0048488)3.47393936
64regulation of synaptic plasticity (GO:0048167)3.47354301
65response to pheromone (GO:0019236)3.44882376
66sodium ion export (GO:0071436)3.44455379
67regulation of neurotransmitter secretion (GO:0046928)3.42461157
68dopamine receptor signaling pathway (GO:0007212)3.42345493
69central nervous system myelination (GO:0022010)3.41005319
70axon ensheathment in central nervous system (GO:0032291)3.41005319
71response to auditory stimulus (GO:0010996)3.40721812
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40515761
73regulation of postsynaptic membrane potential (GO:0060078)3.39518568
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38480996
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35374500
76regulation of vesicle fusion (GO:0031338)3.34620448
77membrane depolarization during action potential (GO:0086010)3.32123949
78regulation of neurotransmitter levels (GO:0001505)3.31394954
79neuromuscular process controlling posture (GO:0050884)3.31375511
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31127708
81adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.30258478
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.29524829
83mitochondrion transport along microtubule (GO:0047497)3.29524829
84positive regulation of dendritic spine development (GO:0060999)3.29452981
85transmission of nerve impulse (GO:0019226)3.29222734
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28944276
87cerebellar Purkinje cell layer development (GO:0021680)3.26122413
88regulation of glutamate secretion (GO:0014048)3.26098032
89cerebellar Purkinje cell differentiation (GO:0021702)3.25679393
90membrane depolarization (GO:0051899)3.24236091
91regulation of female receptivity (GO:0045924)3.24197268
92central nervous system projection neuron axonogenesis (GO:0021952)3.22651548
93neuromuscular synaptic transmission (GO:0007274)3.22345815
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21856226
95glycine transport (GO:0015816)3.21717967
96neuronal ion channel clustering (GO:0045161)3.21587978
97prepulse inhibition (GO:0060134)3.20878287
98vesicle transport along microtubule (GO:0047496)3.19843021
99acidic amino acid transport (GO:0015800)3.17542283
100gamma-aminobutyric acid signaling pathway (GO:0007214)3.16302018
101positive regulation of neurotransmitter secretion (GO:0001956)3.16232805
102establishment of synaptic vesicle localization (GO:0097480)3.14195334
103synaptic vesicle transport (GO:0048489)3.14195334
104regulation of neurotransmitter transport (GO:0051588)3.13033227
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12849123
106negative regulation of amino acid transport (GO:0051956)3.12340301
107synaptic transmission (GO:0007268)3.12139603
108positive regulation of synapse assembly (GO:0051965)3.10483268
109positive regulation of dendritic spine morphogenesis (GO:0061003)3.10460335
110synapse assembly (GO:0007416)3.10133101
111intraspecies interaction between organisms (GO:0051703)3.10094120
112social behavior (GO:0035176)3.10094120
113dendritic spine organization (GO:0097061)3.09820087
114learning (GO:0007612)3.08731447
115positive regulation of neurotransmitter transport (GO:0051590)3.08167787
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07729315
117long-term synaptic potentiation (GO:0060291)3.07192287
118regulation of synaptic transmission, glutamatergic (GO:0051966)3.03964289
119regulation of dendritic spine development (GO:0060998)3.03840861
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02339876
121detection of calcium ion (GO:0005513)2.99963898
122organelle transport along microtubule (GO:0072384)2.98240484
123innervation (GO:0060384)2.97027776
124regulation of ARF protein signal transduction (GO:0032012)2.96890391
125regulation of synaptic transmission, GABAergic (GO:0032228)2.96488089
126positive regulation of synaptic transmission (GO:0050806)2.96418992
127adult walking behavior (GO:0007628)2.96168809
128behavioral fear response (GO:0001662)2.95877212
129behavioral defense response (GO:0002209)2.95877212
130regulation of synaptic transmission (GO:0050804)2.95591333
131membrane hyperpolarization (GO:0060081)2.93939383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16744337
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19923864
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17265993
4GBX2_23144817_ChIP-Seq_PC3_Human3.05258297
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04839285
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.93351236
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83680992
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80950292
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80950292
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.78769829
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.69639775
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.67580881
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63235303
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62922375
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60431196
16* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55837938
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.54059596
18DROSHA_22980978_ChIP-Seq_HELA_Human2.53256025
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.52121181
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51412271
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50322598
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.44673305
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.35281711
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.35168940
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29487975
26* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26535673
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24383217
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89172690
29AR_21572438_ChIP-Seq_LNCaP_Human1.88417721
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85222366
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81045340
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.79048863
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67181007
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53797813
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51506829
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.50723231
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48572854
38ZNF274_21170338_ChIP-Seq_K562_Hela1.48308767
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46689646
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38901776
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36969054
42KDM2B_26808549_Chip-Seq_K562_Human1.34179101
43SMAD4_21799915_ChIP-Seq_A2780_Human1.32027488
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29886607
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28406607
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27281247
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.26332233
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.21736876
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20963593
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20203784
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.19111140
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.18727149
53TAF15_26573619_Chip-Seq_HEK293_Human1.18720351
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17898428
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17432886
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14871059
57AR_19668381_ChIP-Seq_PC3_Human1.13731872
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13462928
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13426449
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11990438
61RNF2_27304074_Chip-Seq_NSC_Mouse1.10808702
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10347375
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10160666
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08220282
65* AR_25329375_ChIP-Seq_VCAP_Human1.06149710
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.05877709
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05682106
68IGF1R_20145208_ChIP-Seq_DFB_Human1.05402127
69P300_19829295_ChIP-Seq_ESCs_Human1.02932419
70CTCF_27219007_Chip-Seq_Bcells_Human1.02217976
71* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01967047
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01866836
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99988137
74ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98964936
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97935267
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97612561
77OCT4_19829295_ChIP-Seq_ESCs_Human0.97422763
78STAT3_23295773_ChIP-Seq_U87_Human0.97339464
79YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97196741
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95834088
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.95362966
82* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95356708
83* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95018873
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94283217
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93290964
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92881847
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.92826209
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91718051
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.91141977
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.90775244
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90310838
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88458805
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.86966031
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86435240
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85413503
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84979864
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84917503
98AHR_22903824_ChIP-Seq_MCF-7_Human0.84578565
99* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84212190
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83838060
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83820498
102* TCF4_23295773_ChIP-Seq_U87_Human0.83263615
103CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82686552
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.82205842
105RUNX2_22187159_ChIP-Seq_PCA_Human0.80697272
106JUN_21703547_ChIP-Seq_K562_Human0.80169625
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79260117
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78983162
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.77838786
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.77286018
111KLF4_19829295_ChIP-Seq_ESCs_Human0.76890189
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75935644
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75736554
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75736554
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75713849
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.74804789
117SMAD4_21741376_ChIP-Seq_ESCs_Human0.71374888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.82010853
2MP0003880_abnormal_central_pattern4.42727071
3MP0003635_abnormal_synaptic_transmissio4.20519154
4MP0004270_analgesia3.54383563
5MP0002063_abnormal_learning/memory/cond3.46529469
6MP0005423_abnormal_somatic_nervous3.40815656
7MP0009745_abnormal_behavioral_response3.35444267
8MP0001968_abnormal_touch/_nociception2.97897547
9MP0002064_seizures2.94113720
10MP0002572_abnormal_emotion/affect_behav2.74198276
11MP0002822_catalepsy2.67919261
12MP0009046_muscle_twitch2.59913110
13MP0003122_maternal_imprinting2.56391698
14MP0002734_abnormal_mechanical_nocicepti2.55386902
15MP0005645_abnormal_hypothalamus_physiol2.49231548
16MP0001486_abnormal_startle_reflex2.40564890
17MP0002272_abnormal_nervous_system2.27486541
18MP0002733_abnormal_thermal_nociception2.16184181
19MP0002735_abnormal_chemical_nociception2.15953614
20MP0009780_abnormal_chondrocyte_physiolo2.11978923
21MP0003787_abnormal_imprinting2.09479101
22MP0000778_abnormal_nervous_system2.09250938
23MP0001440_abnormal_grooming_behavior2.08975815
24MP0002736_abnormal_nociception_after2.04110686
25MP0001501_abnormal_sleep_pattern1.99813371
26MP0001970_abnormal_pain_threshold1.98344014
27MP0006276_abnormal_autonomic_nervous1.97994806
28MP0004811_abnormal_neuron_physiology1.94689776
29MP0002184_abnormal_innervation1.91152869
30MP0004858_abnormal_nervous_system1.90626363
31MP0002557_abnormal_social/conspecific_i1.87667159
32MP0003329_amyloid_beta_deposits1.86627566
33MP0002909_abnormal_adrenal_gland1.77774301
34MP0002067_abnormal_sensory_capabilities1.74541445
35MP0005386_behavior/neurological_phenoty1.70486870
36MP0004924_abnormal_behavior1.70486870
37MP0000955_abnormal_spinal_cord1.67160141
38MP0001984_abnormal_olfaction1.60205644
39MP0008569_lethality_at_weaning1.59137633
40MP0003879_abnormal_hair_cell1.54952603
41MP0004885_abnormal_endolymph1.54274676
42MP0005646_abnormal_pituitary_gland1.52763508
43MP0001502_abnormal_circadian_rhythm1.47461836
44MP0002882_abnormal_neuron_morphology1.45870207
45MP0002066_abnormal_motor_capabilities/c1.39375747
46MP0001905_abnormal_dopamine_level1.29598138
47MP0003123_paternal_imprinting1.26682366
48MP0004142_abnormal_muscle_tone1.22694528
49MP0000569_abnormal_digit_pigmentation1.21165864
50MP0003283_abnormal_digestive_organ1.19703765
51MP0002152_abnormal_brain_morphology1.19570615
52MP0003633_abnormal_nervous_system1.18696768
53MP0001986_abnormal_taste_sensitivity1.18523540
54MP0001529_abnormal_vocalization1.17820279
55MP0000751_myopathy1.15389831
56MP0008961_abnormal_basal_metabolism1.11139757
57MP0003121_genomic_imprinting1.10365854
58MP0002069_abnormal_eating/drinking_beha1.03962950
59MP0000631_abnormal_neuroendocrine_gland1.02401810
60MP0008877_abnormal_DNA_methylation1.01835670
61MP0003631_nervous_system_phenotype0.99626318
62MP0001177_atelectasis0.95683105
63MP0002638_abnormal_pupillary_reflex0.92384927
64MP0001188_hyperpigmentation0.89985959
65MP0003075_altered_response_to0.88812957
66MP0010386_abnormal_urinary_bladder0.88788996
67MP0002653_abnormal_ependyma_morphology0.84425265
68MP0008872_abnormal_physiological_respon0.83751122
69MP0002229_neurodegeneration0.82496439
70MP0005499_abnormal_olfactory_system0.81347848
71MP0005394_taste/olfaction_phenotype0.81347848
72MP0003634_abnormal_glial_cell0.80873204
73MP0000604_amyloidosis0.79327700
74MP0002752_abnormal_somatic_nervous0.77152564
75MP0001348_abnormal_lacrimal_gland0.76665158
76MP0000013_abnormal_adipose_tissue0.75891421
77MP0005167_abnormal_blood-brain_barrier0.75155016
78MP0008874_decreased_physiological_sensi0.72819259
79MP0000026_abnormal_inner_ear0.72690645
80MP0005535_abnormal_body_temperature0.71856319
81MP0001485_abnormal_pinna_reflex0.70925759
82MP0001963_abnormal_hearing_physiology0.69457716
83MP0003137_abnormal_impulse_conducting0.69353830
84MP0003690_abnormal_glial_cell0.68683927
85MP0003861_abnormal_nervous_system0.68683350
86MP0004085_abnormal_heartbeat0.68331201
87MP0004147_increased_porphyrin_level0.68239032
88MP0005623_abnormal_meninges_morphology0.67204453
89MP0005551_abnormal_eye_electrophysiolog0.66092231
90MP0004130_abnormal_muscle_cell0.65491596
91MP0003632_abnormal_nervous_system0.65259008
92MP0004742_abnormal_vestibular_system0.64782661
93MP0004133_heterotaxia0.63270366
94MP0004233_abnormal_muscle_weight0.62611488
95MP0002090_abnormal_vision0.61337292
96MP0003938_abnormal_ear_development0.61091439
97MP0002102_abnormal_ear_morphology0.60396082
98MP0001943_abnormal_respiration0.55400349
99MP0005187_abnormal_penis_morphology0.54966336
100MP0010234_abnormal_vibrissa_follicle0.53762751
101MP0001664_abnormal_digestion0.53725142
102MP0010769_abnormal_survival0.53601196
103MP0002876_abnormal_thyroid_physiology0.52858389
104MP0000920_abnormal_myelination0.52189234
105MP0003172_abnormal_lysosome_physiology0.51925359
106MP0002082_postnatal_lethality0.51830062
107MP0010770_preweaning_lethality0.51830062
108MP0001299_abnormal_eye_distance/0.51595309
109MP0002234_abnormal_pharynx_morphology0.51462034
110MP0010768_mortality/aging0.50545998
111MP0003956_abnormal_body_size0.49608449
112MP0004043_abnormal_pH_regulation0.46851960
113MP0001346_abnormal_lacrimal_gland0.45140584

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.27839301
2Focal motor seizures (HP:0011153)6.39355816
3Visual hallucinations (HP:0002367)5.25214271
4Focal seizures (HP:0007359)5.11037976
5Epileptic encephalopathy (HP:0200134)4.27028481
6Supranuclear gaze palsy (HP:0000605)4.13202682
7Mutism (HP:0002300)4.10450682
8Ankle clonus (HP:0011448)3.96333029
9Progressive cerebellar ataxia (HP:0002073)3.73246636
10Febrile seizures (HP:0002373)3.68526953
11Polyphagia (HP:0002591)3.65834870
12Abnormal eating behavior (HP:0100738)3.50186478
13Absence seizures (HP:0002121)3.47806252
14Depression (HP:0000716)3.47703474
15Atonic seizures (HP:0010819)3.46547047
16Generalized tonic-clonic seizures (HP:0002069)3.41705219
17Papilledema (HP:0001085)3.39851314
18Action tremor (HP:0002345)3.39251464
19Impaired vibration sensation in the lower limbs (HP:0002166)3.35718760
20Poor eye contact (HP:0000817)3.28600902
21Delusions (HP:0000746)3.27276601
22Urinary bladder sphincter dysfunction (HP:0002839)3.17756007
23Dialeptic seizures (HP:0011146)3.13563871
24Cerebral hypomyelination (HP:0006808)3.12629812
25Anxiety (HP:0000739)3.12485220
26Postural instability (HP:0002172)3.05505611
27Abnormality of the lower motor neuron (HP:0002366)3.03392903
28Torticollis (HP:0000473)3.02912043
29Broad-based gait (HP:0002136)3.00460703
30Limb dystonia (HP:0002451)2.92059519
31Abnormal social behavior (HP:0012433)2.90981492
32Impaired social interactions (HP:0000735)2.90981492
33Urinary urgency (HP:0000012)2.89846937
34Genetic anticipation (HP:0003743)2.83612941
35Peripheral hypomyelination (HP:0007182)2.78976887
36Failure to thrive in infancy (HP:0001531)2.78932528
37Agitation (HP:0000713)2.76319847
38Focal dystonia (HP:0004373)2.72664898
39Neurofibrillary tangles (HP:0002185)2.69798153
40Amblyopia (HP:0000646)2.68052385
41Drooling (HP:0002307)2.67027326
42Excessive salivation (HP:0003781)2.67027326
43Amyotrophic lateral sclerosis (HP:0007354)2.63253275
44Dysdiadochokinesis (HP:0002075)2.62597131
45Sleep apnea (HP:0010535)2.62478608
46Spastic gait (HP:0002064)2.61557293
47Dysmetria (HP:0001310)2.61477553
48Split foot (HP:0001839)2.56755951
49Cerebral inclusion bodies (HP:0100314)2.56147348
50Abnormality of the corticospinal tract (HP:0002492)2.56133899
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55672390
52Truncal ataxia (HP:0002078)2.55283052
53Bradykinesia (HP:0002067)2.54393377
54Insomnia (HP:0100785)2.54215134
55Progressive inability to walk (HP:0002505)2.52646628
56Hemiparesis (HP:0001269)2.51661035
57Craniofacial dystonia (HP:0012179)2.49512048
58Ventricular fibrillation (HP:0001663)2.46058207
59Menstrual irregularities (HP:0000858)2.44654743
60Megalencephaly (HP:0001355)2.44247676
61Gait imbalance (HP:0002141)2.39639218
62Lower limb muscle weakness (HP:0007340)2.39627138
63Spastic tetraplegia (HP:0002510)2.37914870
64Hyperventilation (HP:0002883)2.36330382
65Morphological abnormality of the pyramidal tract (HP:0002062)2.36114077
66Hypoventilation (HP:0002791)2.35807218
67Obstructive sleep apnea (HP:0002870)2.35058678
68CNS hypomyelination (HP:0003429)2.34377087
69Akinesia (HP:0002304)2.31428409
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.30338486
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30338486
72Stereotypic behavior (HP:0000733)2.30071268
73Diplopia (HP:0000651)2.29110816
74Abnormality of binocular vision (HP:0011514)2.29110816
75Gaze-evoked nystagmus (HP:0000640)2.28370314
76Apathy (HP:0000741)2.27099109
77Epileptiform EEG discharges (HP:0011182)2.26189723
78Hemiplegia (HP:0002301)2.24652032
79EEG with generalized epileptiform discharges (HP:0011198)2.23908425
80Fetal akinesia sequence (HP:0001989)2.23506531
81Tetraplegia (HP:0002445)2.21438026
82Hypsarrhythmia (HP:0002521)2.19411651
83Termporal pattern (HP:0011008)2.17724591
84Insidious onset (HP:0003587)2.17724591
85Pointed chin (HP:0000307)2.15535341
86Intention tremor (HP:0002080)2.14339309
87Hypercortisolism (HP:0001578)2.13929688
88Poor suck (HP:0002033)2.12513957
89Impaired smooth pursuit (HP:0007772)2.12003051
90Inappropriate behavior (HP:0000719)2.05529898
91Abnormal EKG (HP:0003115)2.04596639
92Hypoplasia of the corpus callosum (HP:0002079)2.04059258
93Inability to walk (HP:0002540)2.03385657
94Diminished motivation (HP:0000745)2.02986260
95Impaired vibratory sensation (HP:0002495)2.02519438
96Pheochromocytoma (HP:0002666)2.01813325
97Scanning speech (HP:0002168)1.99224161
98Lower limb amyotrophy (HP:0007210)1.98023456
99Psychosis (HP:0000709)1.97435180
100Anosmia (HP:0000458)1.97297871
101Clonus (HP:0002169)1.97164541
102Lissencephaly (HP:0001339)1.94348960
103Specific learning disability (HP:0001328)1.94029780
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93982241
105Hypoplasia of the brainstem (HP:0002365)1.93982241
106Absent speech (HP:0001344)1.92941837
107Rapidly progressive (HP:0003678)1.90632240
108Generalized myoclonic seizures (HP:0002123)1.90427528
109Abnormality of the labia minora (HP:0012880)1.89884294
110Abnormal hair whorl (HP:0010721)1.89802792
111Incomplete penetrance (HP:0003829)1.89450349
112Status epilepticus (HP:0002133)1.89195579
113Annular pancreas (HP:0001734)1.89140642
114Hyperthyroidism (HP:0000836)1.88843602
115Rigidity (HP:0002063)1.88764567
116Retinal dysplasia (HP:0007973)1.88140519
117Spastic tetraparesis (HP:0001285)1.88035706
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.86841586
119Neuronal loss in central nervous system (HP:0002529)1.85344213
120Esotropia (HP:0000565)1.80657880
121Paraplegia (HP:0010550)1.79007690
122Ulnar claw (HP:0001178)1.75832058
123Unsteady gait (HP:0002317)1.74399456
124Intellectual disability, severe (HP:0010864)1.74211849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.87189560
2MAP3K94.44122263
3NTRK34.16625279
4EPHA43.81413071
5MINK12.89467180
6MAP3K42.62066652
7NTRK22.52573762
8PAK62.37155181
9DAPK22.23171141
10MAP2K72.19540845
11KSR22.18837141
12MAP3K121.99795002
13KSR11.97056197
14PRKD31.95922269
15CAMKK11.82584277
16PHKG11.72505900
17PHKG21.72505900
18ARAF1.63617563
19CDK51.60661269
20NTRK11.60079451
21MAP2K41.59077173
22MAPK131.57267589
23SIK21.53861724
24LATS21.46381631
25PLK21.43606506
26UHMK11.34890943
27TAOK11.34567599
28TNIK1.32667111
29DAPK11.26801942
30PRPF4B1.23633640
31TYRO31.21135391
32GRK51.18225760
33PRKCG1.17326728
34CASK1.16796248
35MAP3K131.12935926
36STK381.12013221
37MAP3K21.09758827
38CDK191.05309276
39CDK181.02664750
40LMTK21.01611532
41ERBB31.01420550
42CDK151.00031775
43CDK140.97000920
44PAK30.94285562
45FES0.93043509
46CSNK1G20.89022814
47CAMK10.88191565
48CDK11A0.88088052
49MARK20.87975856
50ALK0.87255477
51STK110.85079258
52RAF10.83121850
53CAMK2A0.82167719
54CAMKK20.81345167
55MAP3K110.81271770
56PRKCH0.80120265
57DYRK20.77144691
58RIPK40.75763017
59RET0.75579681
60DYRK1A0.75522105
61TESK10.74636211
62SGK2230.74170102
63SGK4940.74170102
64OXSR10.69547363
65TRIM280.69257171
66PINK10.66220012
67PRKCZ0.63566143
68CSNK1A1L0.60844384
69NEK60.59581653
70MAP3K10.58118848
71MAP4K20.57863499
72SGK10.57439907
73CAMK2B0.54007225
74SCYL20.52370081
75PDPK10.51670140
76PDK10.51252771
77PNCK0.50253127
78RPS6KA20.49885522
79BRSK10.49088753
80CAMK1G0.48776127
81TNK20.48387464
82LIMK10.47758638
83SGK20.47332059
84SIK30.47274018
85MAP2K60.47112627
86CAMK2D0.46953251
87CCNB10.45221051
88SGK30.43867383
89FYN0.43088731
90RPS6KA30.42555318
91CAMK1D0.42068408
92NEK10.41099009
93BRAF0.41008602
94PKN10.40784988
95CAMK2G0.40311333
96CSNK1G10.38834211
97CDC42BPA0.38627993
98CSNK1G30.38036236
99PRKCA0.37579211
100PRKACA0.36975428
101PRKCE0.36387042
102CAMK40.35863360
103MAPK100.35475773
104BCR0.35458894
105DAPK30.34977084
106ICK0.33337909
107RIPK10.33175840
108MAPK120.31766682
109FER0.31738180
110DDR20.31292369
111MAP2K10.31178019
112PRKG10.30679958
113CSNK1E0.30305313
114PTK2B0.30268291
115DMPK0.30125731
116WNK30.29582891
117DYRK1B0.28611273
118PRKCI0.28508499
119CSNK1A10.28332411
120CSNK1D0.28052837
121PRKAA10.27844061
122TAOK20.27336978
123PRKCB0.25935436

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.52906103
2Nicotine addiction_Homo sapiens_hsa050333.47899499
3Olfactory transduction_Homo sapiens_hsa047402.86585770
4GABAergic synapse_Homo sapiens_hsa047272.74346991
5Circadian entrainment_Homo sapiens_hsa047132.65893439
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48308056
7Morphine addiction_Homo sapiens_hsa050322.47203174
8Glutamatergic synapse_Homo sapiens_hsa047242.42535865
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41390838
10Long-term potentiation_Homo sapiens_hsa047202.37962772
11Amphetamine addiction_Homo sapiens_hsa050312.35940495
12Dopaminergic synapse_Homo sapiens_hsa047282.19336068
13Salivary secretion_Homo sapiens_hsa049701.98615271
14Cholinergic synapse_Homo sapiens_hsa047251.98045662
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98015904
16Insulin secretion_Homo sapiens_hsa049111.96085922
17Cocaine addiction_Homo sapiens_hsa050301.89442483
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82607385
19Gastric acid secretion_Homo sapiens_hsa049711.81225137
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67149097
21Oxytocin signaling pathway_Homo sapiens_hsa049211.57999920
22Renin secretion_Homo sapiens_hsa049241.57574103
23Serotonergic synapse_Homo sapiens_hsa047261.55324031
24Long-term depression_Homo sapiens_hsa047301.55060129
25Taste transduction_Homo sapiens_hsa047421.54244359
26GnRH signaling pathway_Homo sapiens_hsa049121.49429244
27Gap junction_Homo sapiens_hsa045401.44618412
28Collecting duct acid secretion_Homo sapiens_hsa049661.40555909
29Calcium signaling pathway_Homo sapiens_hsa040201.39569264
30Axon guidance_Homo sapiens_hsa043601.39234258
31Vitamin B6 metabolism_Homo sapiens_hsa007501.30304303
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28500490
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23371643
34cAMP signaling pathway_Homo sapiens_hsa040241.22792839
35Estrogen signaling pathway_Homo sapiens_hsa049151.19260043
36Glioma_Homo sapiens_hsa052141.18886036
37Melanogenesis_Homo sapiens_hsa049161.18301569
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17932809
39Type II diabetes mellitus_Homo sapiens_hsa049301.12865343
40Vibrio cholerae infection_Homo sapiens_hsa051101.11376026
41ErbB signaling pathway_Homo sapiens_hsa040121.10081681
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97523005
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95889794
44Oocyte meiosis_Homo sapiens_hsa041140.93863204
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93126984
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88613893
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.88538787
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88330617
49Cardiac muscle contraction_Homo sapiens_hsa042600.83846941
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83235466
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.83004075
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82004344
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.80982972
54Endometrial cancer_Homo sapiens_hsa052130.76332523
55Choline metabolism in cancer_Homo sapiens_hsa052310.75711255
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73842919
57Dilated cardiomyopathy_Homo sapiens_hsa054140.73422174
58MAPK signaling pathway_Homo sapiens_hsa040100.72229388
59Dorso-ventral axis formation_Homo sapiens_hsa043200.72172253
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70179891
61Type I diabetes mellitus_Homo sapiens_hsa049400.70171360
62Alcoholism_Homo sapiens_hsa050340.69897523
63Thyroid hormone synthesis_Homo sapiens_hsa049180.69270114
64VEGF signaling pathway_Homo sapiens_hsa043700.66760196
65Prion diseases_Homo sapiens_hsa050200.66400012
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64365149
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62090118
68Ras signaling pathway_Homo sapiens_hsa040140.61478958
69Phototransduction_Homo sapiens_hsa047440.61233591
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60139774
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59834706
72Pancreatic secretion_Homo sapiens_hsa049720.58517293
73Endocytosis_Homo sapiens_hsa041440.57940675
74Alzheimers disease_Homo sapiens_hsa050100.57918380
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56046124
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.55523002
77Rap1 signaling pathway_Homo sapiens_hsa040150.55436906
78Glucagon signaling pathway_Homo sapiens_hsa049220.54101543
79Nitrogen metabolism_Homo sapiens_hsa009100.53531728
80Colorectal cancer_Homo sapiens_hsa052100.53424246
81Non-small cell lung cancer_Homo sapiens_hsa052230.52366010
82Arginine and proline metabolism_Homo sapiens_hsa003300.52330795
83Insulin signaling pathway_Homo sapiens_hsa049100.51795374
84mTOR signaling pathway_Homo sapiens_hsa041500.51308790
85Bile secretion_Homo sapiens_hsa049760.50615699
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50319914
87Wnt signaling pathway_Homo sapiens_hsa043100.49623903
88beta-Alanine metabolism_Homo sapiens_hsa004100.49381931
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49068734
90Renal cell carcinoma_Homo sapiens_hsa052110.48083062
91Oxidative phosphorylation_Homo sapiens_hsa001900.47854497
92Ovarian steroidogenesis_Homo sapiens_hsa049130.46807916
93Butanoate metabolism_Homo sapiens_hsa006500.45991039
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44983671
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44682309
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44578281
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43519604
98Chemokine signaling pathway_Homo sapiens_hsa040620.41480133
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41337843
100Regulation of autophagy_Homo sapiens_hsa041400.40741639
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39268267
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38172937
103Parkinsons disease_Homo sapiens_hsa050120.36849398
104Histidine metabolism_Homo sapiens_hsa003400.35366573
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33748584
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33694242
107Prolactin signaling pathway_Homo sapiens_hsa049170.30379686
108Inositol phosphate metabolism_Homo sapiens_hsa005620.29430009
109AMPK signaling pathway_Homo sapiens_hsa041520.29256786
110Hippo signaling pathway_Homo sapiens_hsa043900.28416035
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28123598
112Circadian rhythm_Homo sapiens_hsa047100.27638182
113Arginine biosynthesis_Homo sapiens_hsa002200.26256593
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.25173452
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24842016
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24831411
117Ether lipid metabolism_Homo sapiens_hsa005650.20731073

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