LY75

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.46876793
2NIK/NF-kappaB signaling (GO:0038061)5.17006403
3antigen processing and presentation of endogenous antigen (GO:0019883)4.93256910
4negative regulation of cell killing (GO:0031342)4.88559491
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88559491
6positive regulation by symbiont of host defense response (GO:0052509)4.74643007
7modulation by symbiont of host defense response (GO:0052031)4.74643007
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.74643007
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.74643007
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.74643007
11modulation by symbiont of host immune response (GO:0052553)4.74643007
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69855356
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.69855356
14B cell receptor signaling pathway (GO:0050853)4.67005982
15regulation of gamma-delta T cell activation (GO:0046643)4.55178152
16negative thymic T cell selection (GO:0045060)4.50648271
17positive regulation of natural killer cell differentiation (GO:0032825)4.45630565
18negative T cell selection (GO:0043383)4.29778329
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23332448
20detection of other organism (GO:0098543)4.12070751
21detection of bacterium (GO:0016045)4.09381778
22positive regulation of B cell differentiation (GO:0045579)4.06951842
23regulation of B cell differentiation (GO:0045577)3.82692193
24macrophage activation involved in immune response (GO:0002281)3.79317786
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.77177065
26CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.73919822
27regulation of RIG-I signaling pathway (GO:0039535)3.73062478
28regulation of interferon-beta biosynthetic process (GO:0045357)3.69308264
29response to interleukin-15 (GO:0070672)3.68231977
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61009103
31cellular response to interleukin-15 (GO:0071350)3.58260481
32cellular extravasation (GO:0045123)3.57927997
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57894226
34negative regulation of T cell mediated immunity (GO:0002710)3.56671768
35natural killer cell mediated cytotoxicity (GO:0042267)3.55698672
36natural killer cell mediated immunity (GO:0002228)3.55698672
37nuclear pore complex assembly (GO:0051292)3.54699035
38tolerance induction (GO:0002507)3.53987295
39positive T cell selection (GO:0043368)3.52298126
40response to host immune response (GO:0052572)3.51184013
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51184013
42regulation of interleukin-12 biosynthetic process (GO:0045075)3.49876898
43B cell homeostasis (GO:0001782)3.47563120
44response to peptidoglycan (GO:0032494)3.46244245
45defense response to protozoan (GO:0042832)3.41320525
46germinal center formation (GO:0002467)3.39739501
47detection of external biotic stimulus (GO:0098581)3.37435712
48regulation of T cell tolerance induction (GO:0002664)3.37159026
49nuclear pore organization (GO:0006999)3.35528056
50positive regulation of gamma-delta T cell activation (GO:0046645)3.34810161
51natural killer cell differentiation (GO:0001779)3.34169067
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.34140450
53B cell mediated immunity (GO:0019724)3.33645200
54regulation of T-helper 1 cell differentiation (GO:0045625)3.32945758
55thymic T cell selection (GO:0045061)3.27604276
56response to protozoan (GO:0001562)3.25758842
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25705447
58response to host (GO:0075136)3.25705447
59response to host defenses (GO:0052200)3.25705447
60positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21697508
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20860892
62positive regulation of interferon-alpha production (GO:0032727)3.19528789
63T cell costimulation (GO:0031295)3.18847615
64lymphocyte costimulation (GO:0031294)3.14979886
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13635991
66regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.11299330
67negative regulation of interleukin-12 production (GO:0032695)3.10754521
68embryonic process involved in female pregnancy (GO:0060136)3.10176191
69antigen receptor-mediated signaling pathway (GO:0050851)3.08753815
70response to type I interferon (GO:0034340)3.07639489
71microglial cell activation (GO:0001774)3.06588527
72type I interferon signaling pathway (GO:0060337)3.06234699
73cellular response to type I interferon (GO:0071357)3.06234699
74regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.05985124
75myeloid dendritic cell differentiation (GO:0043011)3.05629396
76regulation of alpha-beta T cell proliferation (GO:0046640)3.04006053
77cellular response to interferon-gamma (GO:0071346)3.02164075
78cellular response to interferon-alpha (GO:0035457)3.01855952
79positive regulation of interleukin-2 production (GO:0032743)3.00633132
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99799421
81regulation of interferon-alpha production (GO:0032647)2.99617398
82growth hormone receptor signaling pathway (GO:0060396)2.99213970
83positive regulation of granulocyte differentiation (GO:0030854)2.98539739
84neutrophil activation involved in immune response (GO:0002283)2.98198372
85positive regulation of protein homooligomerization (GO:0032464)2.97967875
86T cell selection (GO:0045058)2.96008121
87regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.95553207
88detection of molecule of bacterial origin (GO:0032490)2.95015736
89regulation of natural killer cell differentiation (GO:0032823)2.94854365
90B cell proliferation (GO:0042100)2.94852159
91regulation of B cell proliferation (GO:0030888)2.94778304
92response to muramyl dipeptide (GO:0032495)2.94554128
93regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94410013
94negative regulation of leukocyte mediated immunity (GO:0002704)2.92518167
95detection of biotic stimulus (GO:0009595)2.90762591
96myeloid cell activation involved in immune response (GO:0002275)2.90741722
97negative regulation of B cell proliferation (GO:0030889)2.90451042
98positive regulation of interleukin-12 production (GO:0032735)2.90394710
99positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.89810726
100immunoglobulin mediated immune response (GO:0016064)2.89531102
101natural killer cell activation (GO:0030101)2.88280866
102positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88149179
103positive regulation of protein oligomerization (GO:0032461)2.86623944
104regulation of alpha-beta T cell activation (GO:0046634)2.86289844
105positive regulation of antigen processing and presentation (GO:0002579)2.85590949
106neutrophil activation (GO:0042119)2.85376765
107myeloid dendritic cell activation (GO:0001773)2.83665092
108regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82057811
109JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80251692
110dendritic cell differentiation (GO:0097028)2.80048800
111positive regulation of protein import into nucleus, translocation (GO:0033160)2.79928309
112positive regulation of type 2 immune response (GO:0002830)2.78273728
113granulocyte activation (GO:0036230)2.74270145
114cellular response to virus (GO:0098586)2.74049741
115response to interferon-alpha (GO:0035455)2.72334362
116regulation of tolerance induction (GO:0002643)2.71356495
117interferon-gamma-mediated signaling pathway (GO:0060333)2.69129425
118positive regulation of T-helper cell differentiation (GO:0045624)2.68835736
119regulation of hypersensitivity (GO:0002883)2.67492368
120positive regulation of humoral immune response (GO:0002922)2.66063765
121positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.65659851
122regulation of antigen processing and presentation (GO:0002577)2.63869251
123regulation of interleukin-2 biosynthetic process (GO:0045076)2.62565934
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62445597
125positive regulation of isotype switching (GO:0045830)2.59412605
126pore complex assembly (GO:0046931)2.59164699
127T-helper 1 type immune response (GO:0042088)2.58808553
128hepatocyte apoptotic process (GO:0097284)2.58196655
129regulation of protein import into nucleus, translocation (GO:0033158)2.56989196
130regulation of interleukin-12 production (GO:0032655)2.56207381
131positive regulation of interferon-beta production (GO:0032728)2.55061509
132lymphocyte mediated immunity (GO:0002449)2.54842686
133positive regulation of T cell cytokine production (GO:0002726)2.54780278
134regulation of response to interferon-gamma (GO:0060330)2.54590295
135antigen processing and presentation via MHC class Ib (GO:0002475)2.54029842
136cellular response to zinc ion (GO:0071294)2.53605656
137regulation of necroptotic process (GO:0060544)2.52393252
138regulation of integrin activation (GO:0033623)2.52350111
139endothelial tube morphogenesis (GO:0061154)2.51044968
140morphogenesis of an endothelium (GO:0003159)2.51044968
141cellular response to growth hormone stimulus (GO:0071378)2.49273574
142T-helper cell differentiation (GO:0042093)2.49012618
143CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49012618
144regulation of gamma-delta T cell differentiation (GO:0045586)2.45824666
145T cell apoptotic process (GO:0070231)2.45163874
146leukocyte aggregation (GO:0070486)2.44236325
147positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.43134749
148alpha-beta T cell activation (GO:0046631)2.42935928
149positive thymic T cell selection (GO:0045059)2.42176714
150regulation of T-helper 2 cell differentiation (GO:0045628)2.41592534
151T cell migration (GO:0072678)2.40969984
152cytokine secretion (GO:0050663)2.38538851
153regulation of immunoglobulin secretion (GO:0051023)2.38459123
154regulation of T-helper cell differentiation (GO:0045622)2.37486517
155interferon-gamma secretion (GO:0072643)2.34250526
156regulation of gene silencing by RNA (GO:0060966)2.33231618
157regulation of posttranscriptional gene silencing (GO:0060147)2.33231618
158regulation of gene silencing by miRNA (GO:0060964)2.33231618
159positive regulation of defense response to virus by host (GO:0002230)2.33201764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.36844266
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.70152154
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.60411148
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.42917293
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.48318721
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.39829118
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.33542447
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.23169382
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02068417
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84545173
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.74083970
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.55989085
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41079482
14SCL_19346495_ChIP-Seq_HPC-7_Human2.40099750
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35146748
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.33619849
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11955166
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06049801
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.02712863
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02642659
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97077810
22GATA1_22025678_ChIP-Seq_K562_Human1.96537160
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94161786
24SPI1_23127762_ChIP-Seq_K562_Human1.91683647
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91617488
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91617488
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91617488
28* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86012001
29MYC_22102868_ChIP-Seq_BL_Human1.85461431
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83715380
31MYB_26560356_Chip-Seq_TH2_Human1.83614330
32VDR_24787735_ChIP-Seq_THP-1_Human1.80977761
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80356300
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75278502
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74327977
36MAF_26560356_Chip-Seq_TH1_Human1.74059265
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69887917
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69346840
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68908819
40GATA3_26560356_Chip-Seq_TH2_Human1.67922187
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63320380
42* MYB_26560356_Chip-Seq_TH1_Human1.63056510
43* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59874369
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59420255
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.54095662
46RUNX_20019798_ChIP-Seq_JUKART_Human1.53320101
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51958302
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50676915
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47704638
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46780066
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44785756
52SPI1_23547873_ChIP-Seq_NB4_Human1.44135308
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40329659
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.39974267
55VDR_21846776_ChIP-Seq_THP-1_Human1.39751205
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37826126
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33963491
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.33334132
59CIITA_25753668_ChIP-Seq_RAJI_Human1.33109899
60* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29641970
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29113005
62TCF7_22412390_ChIP-Seq_EML_Mouse1.28810744
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28322453
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28300785
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27337756
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25058821
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.24377723
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22410725
69* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21932577
70UTX_26944678_Chip-Seq_JUKART_Human1.19295018
71TFEB_21752829_ChIP-Seq_HELA_Human1.19092175
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17944752
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16946475
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.16202346
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.15299374
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14759899
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14641710
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13704249
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12093766
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10643965
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10113617
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09961059
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.07292572
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07235948
85GATA1_19941826_ChIP-Seq_K562_Human1.07113562
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07095810
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.06860973
88* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06709377
89* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06586266
90ELK1_19687146_ChIP-ChIP_HELA_Human1.06094758
91* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04838578
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04573754
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02940896
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02358945
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02340441
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02340441
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01949983
98SMRT_27268052_Chip-Seq_Bcells_Human1.01467853
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00934001
100GATA3_27048872_Chip-Seq_THYMUS_Human1.00574966
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00427529
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99605667
103BP1_19119308_ChIP-ChIP_Hs578T_Human0.98978297
104MAF_26560356_Chip-Seq_TH2_Human0.98964349
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97636060
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97587412
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.97044830
108* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96769140
109AR_21909140_ChIP-Seq_LNCAP_Human0.96395067
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96361894
111VDR_24763502_ChIP-Seq_THP-1_Human0.95788798
112PU_27001747_Chip-Seq_BMDM_Mouse0.94463015
113KDM2B_26808549_Chip-Seq_DND41_Human0.94338622
114ZNF263_19887448_ChIP-Seq_K562_Human0.94052234
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93589363
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93054021
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92691502
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92649011
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92027693
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91474291
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91405951
122MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91401216
123GATA2_19941826_ChIP-Seq_K562_Human0.91151211
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89901577
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89330670
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88886472
127NCOR1_26117541_ChIP-Seq_K562_Human0.88120351
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86417107
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.86414110
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85900112
131GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85494994
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84954993
133NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83841127
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83630228
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83586398
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82470240
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82388641
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81701995
139* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81497836
140GATA3_26560356_Chip-Seq_TH1_Human0.73455226
141RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70888554
142BCL6_27268052_Chip-Seq_Bcells_Human0.70640843
143SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69960647
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.67175122
145GATA1_19941827_ChIP-Seq_MEL86_Mouse0.66497010
146P300_27268052_Chip-Seq_Bcells_Human0.63092300
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.62582222
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62253329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.53478911
2MP0000685_abnormal_immune_system3.48385724
3MP0001348_abnormal_lacrimal_gland3.01357383
4MP0002254_reproductive_system_inflammat2.80650243
5MP0010352_gastrointestinal_tract_polyps2.74454931
6MP0005387_immune_system_phenotype2.51157271
7MP0001790_abnormal_immune_system2.51157271
8MP0002166_altered_tumor_susceptibility2.46082582
9MP0001346_abnormal_lacrimal_gland2.39781275
10MP0003436_decreased_susceptibility_to2.33226088
11MP0005671_abnormal_response_to2.32338523
12MP0009785_altered_susceptibility_to2.27107598
13MP0001800_abnormal_humoral_immune2.22880706
14MP0002006_tumorigenesis2.22774923
15MP0002138_abnormal_hepatobiliary_system2.21533940
16MP0005076_abnormal_cell_differentiation2.12354580
17MP0008057_abnormal_DNA_replication2.10403675
18MP0005000_abnormal_immune_tolerance2.07830038
19MP0002148_abnormal_hypersensitivity_rea2.05119403
20MP0002452_abnormal_antigen_presenting2.02164704
21MP0002163_abnormal_gland_morphology1.99090539
22MP0003763_abnormal_thymus_physiology1.93818958
23MP0002009_preneoplasia1.89163979
24MP0002723_abnormal_immune_serum1.86633223
25MP0005025_abnormal_response_to1.83245394
26MP0003866_abnormal_defecation1.78427802
27* MP0001819_abnormal_immune_cell1.77974993
28* MP0002420_abnormal_adaptive_immunity1.75741502
29MP0005310_abnormal_salivary_gland1.74488038
30MP0003705_abnormal_hypodermis_morpholog1.73760534
31MP0003183_abnormal_peptide_metabolism1.71714197
32MP0006082_CNS_inflammation1.70828232
33MP0002398_abnormal_bone_marrow1.69729027
34MP0004510_myositis1.69340695
35MP0004947_skin_inflammation1.68773423
36MP0002877_abnormal_melanocyte_morpholog1.65689761
37MP0003453_abnormal_keratinocyte_physiol1.64997757
38MP0010307_abnormal_tumor_latency1.64957248
39MP0005451_abnormal_body_composition1.64467291
40MP0010155_abnormal_intestine_physiology1.62347722
41MP0002405_respiratory_system_inflammati1.60522617
42MP0003566_abnormal_cell_adhesion1.60448895
43MP0009278_abnormal_bone_marrow1.57798910
44MP0002419_abnormal_innate_immunity1.55288428
45* MP0000716_abnormal_immune_system1.54968019
46MP0000465_gastrointestinal_hemorrhage1.50681153
47MP0010094_abnormal_chromosome_stability1.50284935
48MP0001873_stomach_inflammation1.44853315
49MP0002396_abnormal_hematopoietic_system1.44025836
50MP0003091_abnormal_cell_migration1.43439153
51MP0000858_altered_metastatic_potential1.42232599
52MP0003448_altered_tumor_morphology1.39825721
53MP0002722_abnormal_immune_system1.35425420
54MP0005023_abnormal_wound_healing1.34880240
55MP0004808_abnormal_hematopoietic_stem1.33677912
56MP0003300_gastrointestinal_ulcer1.33625906
57MP0001545_abnormal_hematopoietic_system1.32944411
58MP0005397_hematopoietic_system_phenotyp1.32944411
59MP0003077_abnormal_cell_cycle1.31953772
60MP0003724_increased_susceptibility_to1.31627115
61* MP0002429_abnormal_blood_cell1.31205778
62MP0003172_abnormal_lysosome_physiology1.30884068
63MP0005623_abnormal_meninges_morphology1.29396309
64MP0002277_abnormal_respiratory_mucosa1.28723783
65MP0003303_peritoneal_inflammation1.28391045
66MP0000689_abnormal_spleen_morphology1.27377550
67MP0008007_abnormal_cellular_replicative1.27228490
68MP0000703_abnormal_thymus_morphology1.24268541
69MP0001853_heart_inflammation1.22652947
70MP0003693_abnormal_embryo_hatching1.20338182
71MP0001845_abnormal_inflammatory_respons1.20324682
72MP0000350_abnormal_cell_proliferation1.16879935
73MP0004957_abnormal_blastocyst_morpholog1.16563373
74MP0000490_abnormal_crypts_of1.14692840
75MP0004381_abnormal_hair_follicle1.14651096
76MP0009333_abnormal_splenocyte_physiolog1.12665194
77MP0003111_abnormal_nucleus_morphology1.11812902
78MP0000733_abnormal_muscle_development1.08615732
79MP0004264_abnormal_extraembryonic_tissu1.08014839
80MP0010234_abnormal_vibrissa_follicle1.07556234
81MP0005075_abnormal_melanosome_morpholog1.07391379
82MP0002132_abnormal_respiratory_system1.07010329
83MP0003045_fibrosis1.05141893
84MP0003191_abnormal_cellular_cholesterol1.03602334
85MP0002019_abnormal_tumor_incidence1.01162713
86MP0002998_abnormal_bone_remodeling1.00918665
87MP0005166_decreased_susceptibility_to0.99670004
88MP0000569_abnormal_digit_pigmentation0.98588590
89MP0001533_abnormal_skeleton_physiology0.97012425
90MP0005367_renal/urinary_system_phenotyp0.93650859
91MP0000516_abnormal_urinary_system0.93650859
92MP0001851_eye_inflammation0.93509760
93MP0003828_pulmonary_edema0.91744346
94MP0003941_abnormal_skin_development0.91640241
95MP0002086_abnormal_extraembryonic_tissu0.89083356
96MP0000015_abnormal_ear_pigmentation0.88345978
97MP0008260_abnormal_autophagy0.87782217
98MP0000627_abnormal_mammary_gland0.87614328
99MP0001663_abnormal_digestive_system0.86980873
100MP0005464_abnormal_platelet_physiology0.86467955
101MP0000371_diluted_coat_color0.82672312
102MP0009763_increased_sensitivity_to0.80615808
103MP0002933_joint_inflammation0.80480579
104MP0003075_altered_response_to0.79702527
105MP0004883_abnormal_blood_vessel0.79372797
106MP0000313_abnormal_cell_death0.78714995
107MP0008469_abnormal_protein_level0.78659835
108MP0009764_decreased_sensitivity_to0.78586523
109MP0003252_abnormal_bile_duct0.73706168
110MP0000767_abnormal_smooth_muscle0.72690211
111MP0003656_abnormal_erythrocyte_physiolo0.72309187
112MP0001730_embryonic_growth_arrest0.71923442
113MP0001672_abnormal_embryogenesis/_devel0.71617370
114MP0005380_embryogenesis_phenotype0.71617370
115MP0008058_abnormal_DNA_repair0.71606783
116MP0000249_abnormal_blood_vessel0.70959663
117MP0001915_intracranial_hemorrhage0.70812128
118MP0000613_abnormal_salivary_gland0.70277493
119MP0003984_embryonic_growth_retardation0.70172998
120MP0002088_abnormal_embryonic_growth/wei0.69735360
121MP0000604_amyloidosis0.69689462
122MP0005621_abnormal_cell_physiology0.68842278
123MP0004197_abnormal_fetal_growth/weight/0.68418161
124MP0002139_abnormal_hepatobiliary_system0.68251537
125MP0002693_abnormal_pancreas_physiology0.66726301
126MP0003806_abnormal_nucleotide_metabolis0.66240240
127MP0001293_anophthalmia0.64980913
128MP0009765_abnormal_xenobiotic_induced0.64864316
129MP0002136_abnormal_kidney_physiology0.64464534
130MP0009115_abnormal_fat_cell0.64428267
131MP0000609_abnormal_liver_physiology0.61707812
132MP0003943_abnormal_hepatobiliary_system0.60614318
133MP0008004_abnormal_stomach_pH0.60259697
134MP0005164_abnormal_response_to0.51546943
135MP0008874_decreased_physiological_sensi0.49856120
136MP0001765_abnormal_ion_homeostasis0.49665913
137MP0003795_abnormal_bone_structure0.49046915
138MP0005058_abnormal_lysosome_morphology0.47993289
139MP0005174_abnormal_tail_pigmentation0.47865386

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)4.64287236
2Increased IgM level (HP:0003496)4.60952131
3Agammaglobulinemia (HP:0004432)4.47666679
4Eczematoid dermatitis (HP:0000976)4.20863660
5Gastrointestinal stroma tumor (HP:0100723)4.07223323
6Recurrent sinusitis (HP:0011108)3.96217272
7Recurrent fungal infections (HP:0002841)3.67751867
8Autoimmune hemolytic anemia (HP:0001890)3.54661780
9Recurrent viral infections (HP:0004429)3.51808327
10Abnormality of T cell number (HP:0011839)3.33976846
11Myositis (HP:0100614)3.28906072
12Recurrent abscess formation (HP:0002722)3.27414043
13IgM deficiency (HP:0002850)3.23181276
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.20418641
15Spontaneous hematomas (HP:0007420)3.16467227
16Chronic obstructive pulmonary disease (HP:0006510)3.09510749
17Obstructive lung disease (HP:0006536)3.09510749
18Elevated erythrocyte sedimentation rate (HP:0003565)3.07880835
19Chronic otitis media (HP:0000389)3.05612027
20Orchitis (HP:0100796)3.05116629
21Nasal polyposis (HP:0100582)3.03676223
22Retrobulbar optic neuritis (HP:0100654)3.00982398
23Optic neuritis (HP:0100653)3.00982398
24Eosinophilia (HP:0001880)2.95315060
25Urticaria (HP:0001025)2.88258982
26Chest pain (HP:0100749)2.85038019
27Vasculitis (HP:0002633)2.84237873
28Recurrent bacterial skin infections (HP:0005406)2.82492169
29Mediastinal lymphadenopathy (HP:0100721)2.81984358
30Porencephaly (HP:0002132)2.80657920
31Thrombocytosis (HP:0001894)2.79050774
32Abnormality of B cell number (HP:0010975)2.74333229
33Viral hepatitis (HP:0006562)2.70770291
34Bronchitis (HP:0012387)2.67737369
35Recurrent bronchitis (HP:0002837)2.64572116
36Hypergammaglobulinemia (HP:0010702)2.62965744
37Verrucae (HP:0200043)2.58135148
38Papilloma (HP:0012740)2.58135148
39Abnormality of the nasal mucosa (HP:0000433)2.56827033
40Restrictive lung disease (HP:0002091)2.53813619
41Abnormality of T cells (HP:0002843)2.53727371
42T lymphocytopenia (HP:0005403)2.53297529
43Recurrent cutaneous fungal infections (HP:0011370)2.51258649
44Chronic mucocutaneous candidiasis (HP:0002728)2.51258649
45IgA deficiency (HP:0002720)2.51179304
46B lymphocytopenia (HP:0010976)2.50359997
47Granulocytopenia (HP:0001913)2.45683684
48Osteolytic defects of the hand bones (HP:0009699)2.44565568
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.44565568
50Leukocytosis (HP:0001974)2.44075675
51Arterial thrombosis (HP:0004420)2.42860040
52Abnormality of T cell physiology (HP:0011840)2.40708676
53Abnormality of the fingertips (HP:0001211)2.40603155
54Abnormality of the prostate (HP:0008775)2.40370216
55Amaurosis fugax (HP:0100576)2.39290889
56Hypochromic anemia (HP:0001931)2.37643115
57Recurrent pneumonia (HP:0006532)2.35754845
58Periodontitis (HP:0000704)2.34269063
59Skin rash (HP:0000988)2.34149432
60Peritonitis (HP:0002586)2.33117868
61Fatigue (HP:0012378)2.30978905
62Abnormality of eosinophils (HP:0001879)2.30795336
63Recurrent lower respiratory tract infections (HP:0002783)2.30257139
64Pustule (HP:0200039)2.30125423
65Esophageal varix (HP:0002040)2.30102791
66Abnormality of the pleura (HP:0002103)2.28925467
67Selective tooth agenesis (HP:0001592)2.28713307
68Prolonged bleeding time (HP:0003010)2.26226720
69Epistaxis (HP:0000421)2.25980370
70Recurrent gram-negative bacterial infections (HP:0005420)2.25837529
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.24479751
72Pulmonary embolism (HP:0002204)2.24276799
73Chronic sinusitis (HP:0011109)2.24267745
74Bronchiectasis (HP:0002110)2.23583553
75Gangrene (HP:0100758)2.23392572
76Abnormality of macrophages (HP:0004311)2.23368114
77Cellulitis (HP:0100658)2.16693710
78Gingival bleeding (HP:0000225)2.15452946
79Increased mean platelet volume (HP:0011877)2.14794452
80Abnormal platelet volume (HP:0011876)2.14677608
81Sepsis (HP:0100806)2.13827847
82Interstitial pulmonary disease (HP:0006530)2.13458332
83Recurrent skin infections (HP:0001581)2.11605360
84Joint swelling (HP:0001386)2.11085136
85Papilledema (HP:0001085)2.10378174
86Xerostomia (HP:0000217)2.10058679
87Gastrointestinal infarctions (HP:0005244)2.09760874
88Gingivitis (HP:0000230)2.09176313
89Increased IgE level (HP:0003212)2.08647212
90Cortical dysplasia (HP:0002539)2.08219838
91Colitis (HP:0002583)2.07784906
92Severe combined immunodeficiency (HP:0004430)2.06765431
93Absent frontal sinuses (HP:0002688)2.06482021
94Hematochezia (HP:0002573)2.05854422
95Arthralgia (HP:0002829)2.05411702
96Pulmonary infiltrates (HP:0002113)2.01756336
97Recurrent otitis media (HP:0000403)2.01040381
98Acute hepatic failure (HP:0006554)1.97391283
99Persistence of primary teeth (HP:0006335)1.97369241
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97316576
101Anorexia (HP:0002039)1.96791198
102Short humerus (HP:0005792)1.94360033
103Myocardial infarction (HP:0001658)1.93629686
104Inflammation of the large intestine (HP:0002037)1.93611141
105Lip pit (HP:0100267)1.93428205
106Emphysema (HP:0002097)1.92477799
107Stomatitis (HP:0010280)1.90917992
108Combined immunodeficiency (HP:0005387)1.90320989
109Abnormality of the peritoneum (HP:0002585)1.89308409
110Aplasia/hypoplasia of the humerus (HP:0006507)1.89242655
111Gastrointestinal inflammation (HP:0004386)1.86346495
112IgG deficiency (HP:0004315)1.85215231
113Radial bowing (HP:0002986)1.84927869
114Ulnar bowing (HP:0003031)1.83948730
115Lymphopenia (HP:0001888)1.83890213
116Adactyly (HP:0009776)1.83512676
117Absent hand (HP:0004050)1.83328360
118Hemoptysis (HP:0002105)1.80029012
119Osteomyelitis (HP:0002754)1.79189719
120Fused cervical vertebrae (HP:0002949)1.78764715
121Skin ulcer (HP:0200042)1.78460180
122Chromsome breakage (HP:0040012)1.78192624
123Chronic diarrhea (HP:0002028)1.78042396
124Basal ganglia calcification (HP:0002135)1.77481413
125Meningitis (HP:0001287)1.76873892
126Vertebral compression fractures (HP:0002953)1.73225247
127Premature loss of primary teeth (HP:0006323)1.72848429
128Leukopenia (HP:0001882)1.72110617
129Ependymoma (HP:0002888)1.71944489
130Panhypogammaglobulinemia (HP:0003139)1.71891903
131Syringomyelia (HP:0003396)1.70966854
132Spinal cord lesions (HP:0100561)1.70966854
133Keratoconjunctivitis (HP:0001096)1.70187111
134Cleft eyelid (HP:0000625)1.69487654
135Encephalitis (HP:0002383)1.69189366
136Keratoconjunctivitis sicca (HP:0001097)1.69098139
137Lymphoma (HP:0002665)1.69012244
138Deviation of the thumb (HP:0009603)1.67596886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.21495505
2PRPF4B3.33835727
3JAK33.27593120
4CDK123.25253269
5TYK23.13531932
6IKBKB2.62291076
7TBK12.31358419
8MAP4K12.31322032
9STK102.23412662
10IKBKE2.13220714
11FGFR42.11061361
12CHUK2.02781059
13JAK11.94567512
14MAP3K131.90162513
15TAOK31.88038562
16FES1.84698069
17MST41.77654747
18FGFR31.74985819
19MAP3K101.73692929
20TTN1.72241241
21EPHA21.66950369
22PIM11.50760799
23EPHB11.47910603
24LYN1.45236047
25FLT31.42592739
26CSK1.39069689
27RPS6KA41.38766007
28EPHA31.32398098
29RPS6KB21.32166420
30IRAK41.31515970
31LRRK21.30126820
32GRK61.26274814
33BCR1.22857087
34STK41.19814608
35TGFBR11.17995073
36BMX1.16778467
37TXK1.15255216
38STK241.13118939
39NLK1.13079976
40IRAK11.12093631
41NEK21.09633340
42PRKCQ1.09399494
43SIK31.08612355
44TRPM71.07171718
45PTK61.05974419
46ACVR1B1.02603556
47SIK21.01605666
48TNK21.01069319
49BMPR20.98970380
50ITK0.98771440
51EEF2K0.96614104
52ZAP700.95418550
53STK30.92491378
54MAP3K80.91883723
55ALK0.90862255
56CDK60.90847262
57LCK0.89358151
58CDC70.89196184
59CSF1R0.88265498
60PDK10.87253825
61KIT0.86515429
62CDK40.84485141
63NEK90.84479628
64SMG10.83022128
65MAPK110.81959513
66PIK3CG0.81614611
67CDK190.81544081
68MAP3K10.81069477
69JAK20.80890985
70ERN10.77103901
71PAK40.76070291
72HIPK20.75147178
73ATR0.74710042
74BTK0.74623578
75MELK0.74367129
76HCK0.74249921
77BLK0.74163254
78CDC42BPA0.73417990
79MAPK70.73244026
80SCYL20.73011675
81EIF2AK30.72987617
82CDK70.69641387
83MAPKAPK20.67670775
84PIM20.67606803
85FGR0.63952881
86MATK0.63713568
87NME20.63117936
88PASK0.62900517
89MAPK120.62802687
90TGFBR20.61907000
91WEE10.61812892
92KDR0.61323264
93EIF2AK20.60787985
94SYK0.60755736
95MAP3K20.58040008
96FRK0.56651796
97MAP3K30.55451811
98TESK10.54926037
99NUAK10.54481353
100RIPK40.53513360
101RIPK10.53461508
102PDPK10.53340407
103MTOR0.53270102
104BRD40.52912953
105MARK30.52857053
106PKN20.52208536
107DDR20.51108650
108RPS6KA50.50906107
109MAP2K60.50319118
110CAMKK10.49911259
111CHEK10.49688250
112MOS0.48518998
113MAP3K70.48388270
114IRAK20.47075252
115CDK90.46930874
116YES10.45204499
117EGFR0.45179360
118TTK0.45096465
119AURKB0.44667527
120TEC0.44618510
121MAP3K50.44613185
122CAMKK20.44310873
123CHEK20.44276473
124ATM0.43945487
125INSR0.43548071
126PDGFRA0.43197176
127TAOK20.42672216
128PLK10.41534687
129RPS6KA10.41401925
130MAP2K30.41397774
131FYN0.41371065
132GSK3A0.41042414
133RPS6KC10.38598362
134RPS6KL10.38598362
135LATS10.37820488
136KSR20.36526655
137MAP3K110.36077718
138TRIB30.33622873
139RPS6KA60.33562162
140SGK20.33089767
141ABL10.32014878
142SGK30.31709963
143MARK20.31304529
144PTK2B0.30739642
145PRKCH0.30114319
146MAP2K20.29973494
147MAPK40.28526851

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.16860549
2Graft-versus-host disease_Homo sapiens_hsa053322.87476851
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.69834476
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.60862941
5Leishmaniasis_Homo sapiens_hsa051402.26378581
6Measles_Homo sapiens_hsa051622.19619081
7Primary immunodeficiency_Homo sapiens_hsa053402.02915446
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.99601551
9Autoimmune thyroid disease_Homo sapiens_hsa053201.98245435
10Antigen processing and presentation_Homo sapiens_hsa046121.98101647
11Herpes simplex infection_Homo sapiens_hsa051681.95119238
12TNF signaling pathway_Homo sapiens_hsa046681.88414431
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84634527
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80513745
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78067810
16Apoptosis_Homo sapiens_hsa042101.70829902
17Legionellosis_Homo sapiens_hsa051341.70188803
18Type I diabetes mellitus_Homo sapiens_hsa049401.64117413
19Toxoplasmosis_Homo sapiens_hsa051451.62796984
20Influenza A_Homo sapiens_hsa051641.62239760
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55655002
22Osteoclast differentiation_Homo sapiens_hsa043801.54597695
23Viral myocarditis_Homo sapiens_hsa054161.54035263
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.53738222
25p53 signaling pathway_Homo sapiens_hsa041151.52021574
26One carbon pool by folate_Homo sapiens_hsa006701.45618965
27Small cell lung cancer_Homo sapiens_hsa052221.41852100
28Viral carcinogenesis_Homo sapiens_hsa052031.34493726
29Shigellosis_Homo sapiens_hsa051311.32635102
30T cell receptor signaling pathway_Homo sapiens_hsa046601.29720243
31Hepatitis B_Homo sapiens_hsa051611.28243611
32DNA replication_Homo sapiens_hsa030301.27963882
33B cell receptor signaling pathway_Homo sapiens_hsa046621.26911632
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23268645
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20210370
36Asthma_Homo sapiens_hsa053101.19750887
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15179571
38Mismatch repair_Homo sapiens_hsa034301.14128970
39Chemokine signaling pathway_Homo sapiens_hsa040621.13563614
40Epstein-Barr virus infection_Homo sapiens_hsa051691.12251947
41Hematopoietic cell lineage_Homo sapiens_hsa046401.12038131
42Acute myeloid leukemia_Homo sapiens_hsa052211.10521097
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.09919897
44Chronic myeloid leukemia_Homo sapiens_hsa052201.09583381
45African trypanosomiasis_Homo sapiens_hsa051431.08185612
46Malaria_Homo sapiens_hsa051441.08103558
47MicroRNAs in cancer_Homo sapiens_hsa052061.06812004
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04313286
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03475862
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03352557
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02043379
52HTLV-I infection_Homo sapiens_hsa051661.00728327
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00649471
54Adherens junction_Homo sapiens_hsa045201.00646761
55Tuberculosis_Homo sapiens_hsa051520.97767693
56Pertussis_Homo sapiens_hsa051330.96614952
57Pancreatic cancer_Homo sapiens_hsa052120.94965104
58Hepatitis C_Homo sapiens_hsa051600.94932570
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93773654
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93687865
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92795678
62Salmonella infection_Homo sapiens_hsa051320.89264837
63Base excision repair_Homo sapiens_hsa034100.88612391
64Systemic lupus erythematosus_Homo sapiens_hsa053220.86260556
65Cell cycle_Homo sapiens_hsa041100.85092368
66Notch signaling pathway_Homo sapiens_hsa043300.84938641
67Phagosome_Homo sapiens_hsa041450.82755094
68Prolactin signaling pathway_Homo sapiens_hsa049170.82362543
69RNA transport_Homo sapiens_hsa030130.80496951
70Other glycan degradation_Homo sapiens_hsa005110.78764666
71Proteoglycans in cancer_Homo sapiens_hsa052050.78381413
72Non-homologous end-joining_Homo sapiens_hsa034500.78163200
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77639631
74Rheumatoid arthritis_Homo sapiens_hsa053230.68605791
75HIF-1 signaling pathway_Homo sapiens_hsa040660.64527995
76Homologous recombination_Homo sapiens_hsa034400.63572640
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61797262
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61656402
79Spliceosome_Homo sapiens_hsa030400.60654505
80Pathways in cancer_Homo sapiens_hsa052000.60504613
81TGF-beta signaling pathway_Homo sapiens_hsa043500.59427343
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58781035
83Fanconi anemia pathway_Homo sapiens_hsa034600.56714105
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56254284
85Colorectal cancer_Homo sapiens_hsa052100.55745141
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54289949
87Amoebiasis_Homo sapiens_hsa051460.53493492
88Prostate cancer_Homo sapiens_hsa052150.53260890
89Focal adhesion_Homo sapiens_hsa045100.52836135
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51470946
91Staphylococcus aureus infection_Homo sapiens_hsa051500.50880985
92Thyroid cancer_Homo sapiens_hsa052160.50775608
93Dorso-ventral axis formation_Homo sapiens_hsa043200.50614991
94Hippo signaling pathway_Homo sapiens_hsa043900.50054678
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.49489568
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.47919883
97Nucleotide excision repair_Homo sapiens_hsa034200.45570849
98FoxO signaling pathway_Homo sapiens_hsa040680.44822713
99mTOR signaling pathway_Homo sapiens_hsa041500.43717286
100Platelet activation_Homo sapiens_hsa046110.43165762
101RNA degradation_Homo sapiens_hsa030180.41861011
102Ribosome_Homo sapiens_hsa030100.41277526
103Renal cell carcinoma_Homo sapiens_hsa052110.41008629
104VEGF signaling pathway_Homo sapiens_hsa043700.40772998
105Inositol phosphate metabolism_Homo sapiens_hsa005620.40669091
106Insulin resistance_Homo sapiens_hsa049310.39979225
107Bladder cancer_Homo sapiens_hsa052190.39394251
108mRNA surveillance pathway_Homo sapiens_hsa030150.38181128
109Lysosome_Homo sapiens_hsa041420.36061489
110Non-small cell lung cancer_Homo sapiens_hsa052230.35168115
111GnRH signaling pathway_Homo sapiens_hsa049120.34823767
112Renin-angiotensin system_Homo sapiens_hsa046140.33772179
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31794480
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30795484
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.30091361
116Choline metabolism in cancer_Homo sapiens_hsa052310.29039355
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.25860029
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24754908
119Endometrial cancer_Homo sapiens_hsa052130.23712628
120Type II diabetes mellitus_Homo sapiens_hsa049300.23689434
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.22698454
122MAPK signaling pathway_Homo sapiens_hsa040100.22672404
123Endocytosis_Homo sapiens_hsa041440.19409759
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18915801
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17874263
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17081045
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15227050
128Linoleic acid metabolism_Homo sapiens_hsa005910.12964259
129Arachidonic acid metabolism_Homo sapiens_hsa005900.12171970
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09939461
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09799630
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09407544

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