LY75-CD302

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring lymphocyte antigen 75 (LY75) and CD302 molecule (CD302) genes. Alternative splicing results in multiple transcript variants encoding fusion products that share sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.30997736
2regulation of B cell receptor signaling pathway (GO:0050855)6.07832122
3B cell receptor signaling pathway (GO:0050853)4.85798234
4immunoglobulin mediated immune response (GO:0016064)4.71331728
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.68644118
6antigen processing and presentation of endogenous antigen (GO:0019883)4.55994187
7positive regulation of B cell differentiation (GO:0045579)4.53165050
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.49948546
9modulation by symbiont of host immune response (GO:0052553)4.49948546
10positive regulation by symbiont of host defense response (GO:0052509)4.49948546
11modulation by symbiont of host defense response (GO:0052031)4.49948546
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.49948546
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.49948546
14regulation of gamma-delta T cell activation (GO:0046643)4.41064030
15negative thymic T cell selection (GO:0045060)4.36680851
16positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.28769228
17negative T cell selection (GO:0043383)4.27520713
18detection of other organism (GO:0098543)4.24641077
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19129716
20negative regulation of cell killing (GO:0031342)4.19129716
21detection of molecule of bacterial origin (GO:0032490)4.16122423
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15687789
23regulation of gamma-delta T cell differentiation (GO:0045586)4.09565952
24microglial cell activation (GO:0001774)4.07262194
25interferon-gamma-mediated signaling pathway (GO:0060333)4.03489634
26B cell mediated immunity (GO:0019724)4.02404192
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99290549
28detection of bacterium (GO:0016045)3.97426335
29positive thymic T cell selection (GO:0045059)3.96849273
30regulation of B cell differentiation (GO:0045577)3.94468799
31regulation of alpha-beta T cell proliferation (GO:0046640)3.93176342
32cellular extravasation (GO:0045123)3.92638782
33macrophage activation involved in immune response (GO:0002281)3.91216587
34T cell migration (GO:0072678)3.91070706
35response to peptidoglycan (GO:0032494)3.90010698
36detection of external biotic stimulus (GO:0098581)3.88662766
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87710590
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.85251032
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.83232903
40neutrophil activation involved in immune response (GO:0002283)3.65980538
41T-helper 1 type immune response (GO:0042088)3.62985240
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.60636230
43regulation of interferon-beta biosynthetic process (GO:0045357)3.57527496
44negative regulation of B cell proliferation (GO:0030889)3.56555460
45positive T cell selection (GO:0043368)3.50058658
46myeloid cell activation involved in immune response (GO:0002275)3.46098337
47negative regulation of interleukin-12 production (GO:0032695)3.45993925
48positive regulation of mast cell activation (GO:0033005)3.44997565
49detection of biotic stimulus (GO:0009595)3.44050356
50response to host immune response (GO:0052572)3.43290653
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43290653
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41654395
53negative regulation of T cell mediated immunity (GO:0002710)3.37136508
54macrophage activation (GO:0042116)3.28529721
55mast cell activation (GO:0045576)3.25981247
56regulation of mast cell activation (GO:0033003)3.25145391
57regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20794309
58regulation of hypersensitivity (GO:0002883)3.19390902
59positive regulation of interferon-alpha production (GO:0032727)3.17910422
60T cell selection (GO:0045058)3.17434237
61response to muramyl dipeptide (GO:0032495)3.17256775
62regulation of B cell proliferation (GO:0030888)3.14791617
63response to host (GO:0075136)3.12534162
64response to host defenses (GO:0052200)3.12534162
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12534162
66T cell costimulation (GO:0031295)3.12374167
67hepatocyte apoptotic process (GO:0097284)3.11226490
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.10825002
69antigen receptor-mediated signaling pathway (GO:0050851)3.10442177
70cellular response to interferon-gamma (GO:0071346)3.09429123
71lymphocyte costimulation (GO:0031294)3.07779182
72neutrophil mediated immunity (GO:0002446)3.07754871
73regulation of mast cell degranulation (GO:0043304)3.07673103
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.06502470
75Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05061254
76regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04764951
77response to interleukin-15 (GO:0070672)3.04460182
78respiratory burst (GO:0045730)3.04114309
79cellular response to type I interferon (GO:0071357)3.03093896
80type I interferon signaling pathway (GO:0060337)3.03093896
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.03093539
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02794380
83mature B cell differentiation involved in immune response (GO:0002313)3.00770611
84response to type I interferon (GO:0034340)2.99927989
85B cell proliferation (GO:0042100)2.97135315
86positive regulation of B cell activation (GO:0050871)2.96889070
87regulation of interferon-alpha production (GO:0032647)2.96492162
88regulation of antigen processing and presentation (GO:0002577)2.95091935
89positive regulation of immunoglobulin mediated immune response (GO:0002891)2.92317406
90positive regulation of B cell mediated immunity (GO:0002714)2.92317406
91thymic T cell selection (GO:0045061)2.91892544
92B cell homeostasis (GO:0001782)2.91232322
93defense response to protozoan (GO:0042832)2.90756570
94positive regulation of mast cell degranulation (GO:0043306)2.90536443
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.90536443
96positive regulation of B cell proliferation (GO:0030890)2.88791729
97mature B cell differentiation (GO:0002335)2.88575676
98response to protozoan (GO:0001562)2.87976349
99regulation of mast cell activation involved in immune response (GO:0033006)2.86878364
100positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.86769804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.86069962
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.30981280
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.15059811
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.14653519
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.11563865
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93432694
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73995715
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.63420966
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61781507
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.27565600
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.17549078
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15647052
13MYB_26560356_Chip-Seq_TH2_Human3.05117279
14SCL_19346495_ChIP-Seq_HPC-7_Human2.89045343
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85433248
16SPI1_23547873_ChIP-Seq_NB4_Human2.81797831
17RUNX_20019798_ChIP-Seq_JUKART_Human2.72713768
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71173626
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60801775
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52139272
21MYB_26560356_Chip-Seq_TH1_Human2.43540164
22VDR_24763502_ChIP-Seq_THP-1_Human2.27615822
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19232987
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17182574
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16720378
26MAF_26560356_Chip-Seq_TH1_Human2.15491823
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12660591
28GATA3_27048872_Chip-Seq_THYMUS_Human2.12462770
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10329790
30SPI1_23127762_ChIP-Seq_K562_Human2.10166795
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05799746
32GATA1_22025678_ChIP-Seq_K562_Human2.04606593
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04596376
34MYC_22102868_ChIP-Seq_BL_Human2.04471529
35VDR_21846776_ChIP-Seq_THP-1_Human2.04264846
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90504241
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85931429
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81220779
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.78914450
40UTX_26944678_Chip-Seq_JUKART_Human1.75399282
41GATA3_26560356_Chip-Seq_TH2_Human1.75349456
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.71251867
43VDR_24787735_ChIP-Seq_THP-1_Human1.70301085
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59569903
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52111038
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51494588
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51419147
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51014961
49CIITA_25753668_ChIP-Seq_RAJI_Human1.49242876
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48707364
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47344642
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.46074830
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45670931
54PU_27001747_Chip-Seq_BMDM_Mouse1.43932827
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41413272
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39334928
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35920700
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34884798
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34261676
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32271873
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.27578056
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27010778
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26434326
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25518928
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21470905
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21383977
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17611643
68MAF_26560356_Chip-Seq_TH2_Human1.16704750
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15092370
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06805854
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05879904
72TCF7_22412390_ChIP-Seq_EML_Mouse1.01022484
73VDR_23849224_ChIP-Seq_CD4+_Human1.00868878
74GATA1_19941826_ChIP-Seq_K562_Human1.00799572
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99109071
76TFEB_21752829_ChIP-Seq_HELA_Human0.98752117
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96357895
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94930728
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93502511
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93429895
81ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90862272
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90494274
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90168263
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89904172
85GATA2_19941826_ChIP-Seq_K562_Human0.89823251
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.88774866
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83643076
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82234447
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81777666
90SMRT_27268052_Chip-Seq_Bcells_Human0.80774703
91SALL4_22934838_ChIP-ChIP_CD34+_Human0.80530260
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79517887
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77999275
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76328660
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76249208
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76188479
97SPI1_20517297_ChIP-Seq_HL60_Human0.76153022
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.75543179
99GATA3_26560356_Chip-Seq_TH1_Human0.72158264
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70765856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.76359645
2MP0005671_abnormal_response_to3.71687363
3MP0000685_abnormal_immune_system3.31785955
4MP0001800_abnormal_humoral_immune3.18523069
5MP0003724_increased_susceptibility_to2.97607689
6MP0005000_abnormal_immune_tolerance2.88866392
7MP0003436_decreased_susceptibility_to2.83659494
8MP0003763_abnormal_thymus_physiology2.75531242
9MP0003303_peritoneal_inflammation2.74962069
10MP0001790_abnormal_immune_system2.74597737
11MP0005387_immune_system_phenotype2.74597737
12MP0002452_abnormal_antigen_presenting2.68151015
13MP0002166_altered_tumor_susceptibility2.62185068
14MP0002723_abnormal_immune_serum2.60374445
15MP0002419_abnormal_innate_immunity2.59617930
16MP0005025_abnormal_response_to2.53878656
17MP0009785_altered_susceptibility_to2.50787141
18MP0002420_abnormal_adaptive_immunity2.50549183
19MP0001819_abnormal_immune_cell2.47752500
20MP0000569_abnormal_digit_pigmentation2.43958439
21MP0002148_abnormal_hypersensitivity_rea2.33808057
22MP0005464_abnormal_platelet_physiology2.28544283
23MP0002398_abnormal_bone_marrow2.15750435
24MP0002396_abnormal_hematopoietic_system2.15711366
25MP0000716_abnormal_immune_system2.02078121
26MP0002006_tumorigenesis1.96184345
27MP0003300_gastrointestinal_ulcer1.94205629
28MP0005451_abnormal_body_composition1.90274380
29MP0003172_abnormal_lysosome_physiology1.84247913
30MP0003183_abnormal_peptide_metabolism1.80449408
31MP0000689_abnormal_spleen_morphology1.78727513
32MP0006082_CNS_inflammation1.77843675
33MP0010155_abnormal_intestine_physiology1.77111367
34MP0008057_abnormal_DNA_replication1.76951309
35MP0009278_abnormal_bone_marrow1.74573781
36MP0005397_hematopoietic_system_phenotyp1.70606177
37MP0001545_abnormal_hematopoietic_system1.70606177
38MP0001845_abnormal_inflammatory_respons1.69389516
39MP0002722_abnormal_immune_system1.68937783
40MP0002405_respiratory_system_inflammati1.66870754
41MP0002429_abnormal_blood_cell1.64399525
42MP0000465_gastrointestinal_hemorrhage1.58661570
43MP0002009_preneoplasia1.52640284
44MP0008260_abnormal_autophagy1.51970818
45MP0001853_heart_inflammation1.47429687
46MP0005075_abnormal_melanosome_morpholog1.47386134
47MP0004947_skin_inflammation1.45733279
48MP0000015_abnormal_ear_pigmentation1.42991063
49MP0000703_abnormal_thymus_morphology1.42213645
50MP0003866_abnormal_defecation1.41095420
51MP0005310_abnormal_salivary_gland1.39931460
52MP0009333_abnormal_splenocyte_physiolog1.37340342
53MP0003806_abnormal_nucleotide_metabolis1.32882622
54MP0009764_decreased_sensitivity_to1.32152106
55MP0003191_abnormal_cellular_cholesterol1.31445430
56MP0003828_pulmonary_edema1.29333945
57MP0008469_abnormal_protein_level1.27543092
58MP0004381_abnormal_hair_follicle1.21251500
59MP0001533_abnormal_skeleton_physiology1.21217539
60MP0005645_abnormal_hypothalamus_physiol1.19854067
61MP0005058_abnormal_lysosome_morphology1.18151635
62MP0004808_abnormal_hematopoietic_stem1.17800609
63MP0003656_abnormal_erythrocyte_physiolo1.15128105
64MP0003075_altered_response_to1.14623376
65MP0004883_abnormal_blood_vessel1.10907488
66MP0000858_altered_metastatic_potential1.06226535
67MP0002138_abnormal_hepatobiliary_system1.03522407
68MP0005166_decreased_susceptibility_to1.02347331
69MP0002132_abnormal_respiratory_system0.98512067
70MP0000604_amyloidosis0.95861277
71MP0005174_abnormal_tail_pigmentation0.92690886
72MP0002019_abnormal_tumor_incidence0.90670571
73MP0009763_increased_sensitivity_to0.89537935
74MP0002998_abnormal_bone_remodeling0.84620157
75MP0001851_eye_inflammation0.79751709
76MP0000249_abnormal_blood_vessel0.79184112
77MP0003045_fibrosis0.78200911
78MP0003787_abnormal_imprinting0.77892950
79MP0003448_altered_tumor_morphology0.77702213
80MP0005164_abnormal_response_to0.75880472
81MP0009765_abnormal_xenobiotic_induced0.75542102
82MP0008004_abnormal_stomach_pH0.74015269
83MP0000371_diluted_coat_color0.73688327
84MP0003091_abnormal_cell_migration0.70270140
85MP0003690_abnormal_glial_cell0.68895873
86MP0003252_abnormal_bile_duct0.61911237
87MP0001873_stomach_inflammation0.58016753
88MP0000343_altered_response_to0.57294398
89MP0002136_abnormal_kidney_physiology0.56649590
90MP0005376_homeostasis/metabolism_phenot0.56322673
91MP0001663_abnormal_digestive_system0.53510561
92MP0005584_abnormal_enzyme/coenzyme_acti0.53193070
93MP0002693_abnormal_pancreas_physiology0.51780640
94MP0005535_abnormal_body_temperature0.49313451
95MP0005167_abnormal_blood-brain_barrier0.48857474
96MP0000609_abnormal_liver_physiology0.47295936
97MP0005266_abnormal_metabolism0.47139820
98MP0004264_abnormal_extraembryonic_tissu0.44821842
99MP0005621_abnormal_cell_physiology0.43772480
100MP0002933_joint_inflammation0.42929193

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.51737039
2Recurrent abscess formation (HP:0002722)4.92324741
3Eczematoid dermatitis (HP:0000976)4.51686510
4Meningitis (HP:0001287)4.39707149
5Recurrent fungal infections (HP:0002841)4.39222467
6Agammaglobulinemia (HP:0004432)4.38582486
7Elevated erythrocyte sedimentation rate (HP:0003565)4.25285713
8Recurrent viral infections (HP:0004429)4.18389102
9Panhypogammaglobulinemia (HP:0003139)4.16930696
10Chronic mucocutaneous candidiasis (HP:0002728)4.06726397
11Recurrent cutaneous fungal infections (HP:0011370)4.06726397
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.06136975
13Vasculitis (HP:0002633)4.05092146
14T lymphocytopenia (HP:0005403)3.99381847
15Recurrent skin infections (HP:0001581)3.96442320
16Mediastinal lymphadenopathy (HP:0100721)3.93873208
17Abnormality of macrophages (HP:0004311)3.82788236
18Abnormality of T cell number (HP:0011839)3.79637227
19Myositis (HP:0100614)3.78242993
20IgM deficiency (HP:0002850)3.68782727
21Colitis (HP:0002583)3.66139227
22Retrobulbar optic neuritis (HP:0100654)3.59761743
23Optic neuritis (HP:0100653)3.59761743
24Recurrent bronchitis (HP:0002837)3.56855907
25Orchitis (HP:0100796)3.48757873
26Abnormality of T cells (HP:0002843)3.48327874
27Chronic obstructive pulmonary disease (HP:0006510)3.47630741
28Obstructive lung disease (HP:0006536)3.47630741
29Encephalitis (HP:0002383)3.47134577
30Recurrent gram-negative bacterial infections (HP:0005420)3.45473221
31Gastrointestinal stroma tumor (HP:0100723)3.45076698
32Chronic diarrhea (HP:0002028)3.35621538
33Autoimmune hemolytic anemia (HP:0001890)3.28385331
34Cellulitis (HP:0100658)3.27128038
35Inflammation of the large intestine (HP:0002037)3.25593645
36Urticaria (HP:0001025)3.22416271
37Spontaneous hematomas (HP:0007420)3.17798371
38IgA deficiency (HP:0002720)3.12489609
39Abnormality of T cell physiology (HP:0011840)3.10644865
40Abnormality of B cell number (HP:0010975)3.10333659
41Chest pain (HP:0100749)3.06931971
42Gastrointestinal infarctions (HP:0005244)3.04474461
43Gastrointestinal inflammation (HP:0004386)3.04215638
44B lymphocytopenia (HP:0010976)3.03109878
45Recurrent sinusitis (HP:0011108)3.02906084
46Lymphopenia (HP:0001888)3.01464427
47Gingival bleeding (HP:0000225)2.93410883
48Hemoptysis (HP:0002105)2.89807709
49Pulmonary infiltrates (HP:0002113)2.88898413
50Abnormality of the prostate (HP:0008775)2.88081558
51Viral hepatitis (HP:0006562)2.85155398
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.83590799
53Keratoconjunctivitis sicca (HP:0001097)2.75425364
54Epistaxis (HP:0000421)2.75050985
55Stomatitis (HP:0010280)2.71145333
56Arterial thrombosis (HP:0004420)2.70098851
57Granulocytopenia (HP:0001913)2.67569699
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65427177
59Osteomyelitis (HP:0002754)2.60581056
60IgG deficiency (HP:0004315)2.58692602
61Vacuolated lymphocytes (HP:0001922)2.56929980
62Gingivitis (HP:0000230)2.56562512
63Leukocytosis (HP:0001974)2.55612188
64Keratoconjunctivitis (HP:0001096)2.53415979
65Autoimmune thrombocytopenia (HP:0001973)2.49586752
66Skin rash (HP:0000988)2.49413626
67Fatigue (HP:0012378)2.49396442
68Abnormality of the pleura (HP:0002103)2.46234176
69Amaurosis fugax (HP:0100576)2.46100311
70Acute hepatic failure (HP:0006554)2.45506401
71Prolonged bleeding time (HP:0003010)2.44922486
72Increased IgE level (HP:0003212)2.44061976
73Eosinophilia (HP:0001880)2.36120103
74Restrictive lung disease (HP:0002091)2.32069736
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31032036
76Verrucae (HP:0200043)2.28118357
77Papilloma (HP:0012740)2.28118357
78Recurrent pneumonia (HP:0006532)2.27884882
79Severe combined immunodeficiency (HP:0004430)2.27853881
80Petechiae (HP:0000967)2.27551098
81Pulmonary embolism (HP:0002204)2.26416089
82Sepsis (HP:0100806)2.25684660
83Abnormality of the peritoneum (HP:0002585)2.22747508
84Gangrene (HP:0100758)2.22473248
85Amyloidosis (HP:0011034)2.21294863
86Chronic otitis media (HP:0000389)2.19339986
87Hypoplasia of the thymus (HP:0000778)2.18876058
88Increased IgM level (HP:0003496)2.16226149
89Recurrent lower respiratory tract infections (HP:0002783)2.14327578
90Conjunctival telangiectasia (HP:0000524)2.08561128
91Abnormality of eosinophils (HP:0001879)2.06462161
92Lymphoma (HP:0002665)2.04785440
93Thyroiditis (HP:0100646)2.03421000
94Skin ulcer (HP:0200042)2.01634134
95Bronchitis (HP:0012387)2.00250799
96Hypergammaglobulinemia (HP:0010702)1.98426062
97Mucosal telangiectasiae (HP:0100579)1.97606294
98Thrombocytosis (HP:0001894)1.97362744
99Thrombophlebitis (HP:0004418)1.94134047
100Anorexia (HP:0002039)1.93317022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.41106574
2MAP4K13.60626613
3BLK3.55389859
4TAOK33.05256315
5MAP3K142.87079930
6TYK22.56850248
7BTK2.52796437
8SYK2.50998137
9BMPR22.38811145
10TEC2.35502411
11KIT2.21809987
12FES2.15270768
13JAK32.09485355
14IRAK42.09066681
15IKBKE2.02559558
16CSF1R1.97042955
17JAK11.92626101
18PIK3CG1.86227933
19ITK1.85150806
20CSK1.79743941
21TLK11.79286625
22MAP2K31.74239710
23TXK1.66256180
24GRK61.65396123
25LYN1.64520714
26PRPF4B1.56509778
27IKBKB1.50823000
28VRK11.46689601
29TRPM71.46434524
30TBK11.45709826
31HCK1.44362307
32ZAK1.43999420
33MAP4K21.41223027
34MAP3K131.38292728
35ZAP701.33888033
36SCYL21.22189287
37PIM11.20935118
38FGR1.19404726
39LCK1.19400673
40MATK1.19305558
41JAK21.17079474
42FGFR31.15192231
43TNK21.09731128
44ERN10.94954746
45NEK90.94186676
46TESK20.92131356
47PRKCQ0.91994832
48PDK10.90300100
49MAP3K20.89296041
50STK40.88130225
51MAP3K10.86219986
52DAPK30.82746375
53RPS6KA50.81468576
54FRK0.80685628
55MARK30.78176908
56MAP3K50.76700607
57STK100.73520617
58MAPK110.62955841
59MAP3K30.61472230
60IRAK10.61429962
61CDK120.60071458
62MAP3K120.59073151
63EIF2AK30.57916530
64MELK0.56692486
65RPS6KB20.55022112
66CHUK0.54324625
67NLK0.52498645
68MAP3K110.51974662
69YES10.51835691
70MAPK70.50410659
71PTK2B0.50273506
72MAPK120.49362088
73CDK60.49034528
74PDPK10.46817672
75IRAK20.45973746
76CDK40.45967254
77FLT30.43840183
78FYN0.42818790
79SGK20.42154356
80STK240.41279493
81ABL10.39678438
82EGFR0.38644176
83HIPK20.35096960
84KDR0.34718372
85RAF10.34176873
86GRK70.33657832
87MST40.33410992
88SMG10.31482572
89FGFR40.30999720
90PASK0.29888669
91BRD40.29006696
92LRRK20.28148894
93CAMKK20.27144157
94SGK30.26553692
95CDC42BPA0.26416923
96NUAK10.25892055
97GRK50.24769058
98PRKCD0.23748301
99DYRK1B0.22773728
100IGF1R0.22655375

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.15258944
2Asthma_Homo sapiens_hsa053104.14576894
3Autoimmune thyroid disease_Homo sapiens_hsa053203.90602153
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.90255853
5Graft-versus-host disease_Homo sapiens_hsa053323.86982820
6Systemic lupus erythematosus_Homo sapiens_hsa053223.48660281
7Type I diabetes mellitus_Homo sapiens_hsa049403.36636163
8Leishmaniasis_Homo sapiens_hsa051403.29828311
9Primary immunodeficiency_Homo sapiens_hsa053402.92917319
10Staphylococcus aureus infection_Homo sapiens_hsa051502.87183565
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.72039195
12Antigen processing and presentation_Homo sapiens_hsa046122.47634188
13Viral myocarditis_Homo sapiens_hsa054162.36850876
14B cell receptor signaling pathway_Homo sapiens_hsa046622.24847915
15Tuberculosis_Homo sapiens_hsa051521.95715600
16Hematopoietic cell lineage_Homo sapiens_hsa046401.81332549
17Osteoclast differentiation_Homo sapiens_hsa043801.80012009
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.74430616
19Influenza A_Homo sapiens_hsa051641.67129252
20Rheumatoid arthritis_Homo sapiens_hsa053231.66940392
21Toxoplasmosis_Homo sapiens_hsa051451.66911512
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62244164
23Herpes simplex infection_Homo sapiens_hsa051681.58380392
24Alcoholism_Homo sapiens_hsa050341.53941700
25Measles_Homo sapiens_hsa051621.44520122
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43971622
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32400176
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25018601
29Other glycan degradation_Homo sapiens_hsa005111.18989621
30Viral carcinogenesis_Homo sapiens_hsa052031.18518634
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17503826
32T cell receptor signaling pathway_Homo sapiens_hsa046601.14609629
33Phagosome_Homo sapiens_hsa041451.13995758
34Legionellosis_Homo sapiens_hsa051341.05832542
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.03262433
36Platelet activation_Homo sapiens_hsa046111.02236912
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02222049
38Epstein-Barr virus infection_Homo sapiens_hsa051690.98168154
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94563083
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93080143
41Hepatitis B_Homo sapiens_hsa051610.87182909
42Chemokine signaling pathway_Homo sapiens_hsa040620.86926221
43Acute myeloid leukemia_Homo sapiens_hsa052210.83894206
44Malaria_Homo sapiens_hsa051440.82635778
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82588003
46TNF signaling pathway_Homo sapiens_hsa046680.80730413
47Apoptosis_Homo sapiens_hsa042100.75834103
48Non-small cell lung cancer_Homo sapiens_hsa052230.69011759
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.68751642
50Shigellosis_Homo sapiens_hsa051310.61936808
51Pertussis_Homo sapiens_hsa051330.60603340
52Hepatitis C_Homo sapiens_hsa051600.58774345
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57699047
54African trypanosomiasis_Homo sapiens_hsa051430.56419236
55HTLV-I infection_Homo sapiens_hsa051660.55844451
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54411465
57Salmonella infection_Homo sapiens_hsa051320.51423322
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50466454
59Lysosome_Homo sapiens_hsa041420.49003481
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48419601
61Pancreatic cancer_Homo sapiens_hsa052120.46770421
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42824097
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40441286
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.37323577
65Prolactin signaling pathway_Homo sapiens_hsa049170.37253382
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33345725
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33160368
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32764140
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.32315303
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30102200
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29356563
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28619007
73Dorso-ventral axis formation_Homo sapiens_hsa043200.27785689
74Renin-angiotensin system_Homo sapiens_hsa046140.27581930
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.25334390
76HIF-1 signaling pathway_Homo sapiens_hsa040660.24633326
77Chronic myeloid leukemia_Homo sapiens_hsa052200.24382608
78Inositol phosphate metabolism_Homo sapiens_hsa005620.23318383
79FoxO signaling pathway_Homo sapiens_hsa040680.22216693
80Pentose phosphate pathway_Homo sapiens_hsa000300.15059143
81Caffeine metabolism_Homo sapiens_hsa002320.13950587
82VEGF signaling pathway_Homo sapiens_hsa043700.13637906
83Non-homologous end-joining_Homo sapiens_hsa034500.12375140
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.12238997
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12037365
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12034491
87GnRH signaling pathway_Homo sapiens_hsa049120.11805349
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10119514
89Type II diabetes mellitus_Homo sapiens_hsa049300.10086846
90Amoebiasis_Homo sapiens_hsa051460.09661906
91mTOR signaling pathway_Homo sapiens_hsa041500.09577817
92Regulation of autophagy_Homo sapiens_hsa041400.09394495
93Renal cell carcinoma_Homo sapiens_hsa052110.08890089
94p53 signaling pathway_Homo sapiens_hsa041150.08605295
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08331152
96Insulin resistance_Homo sapiens_hsa049310.06717121
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.02945069
98MAPK signaling pathway_Homo sapiens_hsa040100.02782738
99Galactose metabolism_Homo sapiens_hsa000520.02558180
100Endocytosis_Homo sapiens_hsa041440.01854010

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