LY86

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.75885727
2regulation of interferon-beta biosynthetic process (GO:0045357)5.99308086
3neutrophil activation involved in immune response (GO:0002283)5.95678916
4microglial cell activation (GO:0001774)5.82779525
5macrophage activation involved in immune response (GO:0002281)5.69701808
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.59597687
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.59597687
8modulation by symbiont of host immune response (GO:0052553)5.59597687
9positive regulation by symbiont of host defense response (GO:0052509)5.59597687
10modulation by symbiont of host defense response (GO:0052031)5.59597687
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.59597687
12regulation of B cell receptor signaling pathway (GO:0050855)5.43803321
13positive regulation of interferon-alpha production (GO:0032727)5.15675674
14respiratory burst (GO:0045730)4.89368900
15regulation of interferon-alpha production (GO:0032647)4.85699415
16negative regulation of interleukin-12 production (GO:0032695)4.67372531
17positive regulation of antigen processing and presentation (GO:0002579)4.66272329
18macrophage activation (GO:0042116)4.61608315
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.60466560
20immunoglobulin mediated immune response (GO:0016064)4.60010286
21granulocyte activation (GO:0036230)4.44437502
22myeloid cell activation involved in immune response (GO:0002275)4.34963548
23neutrophil activation (GO:0042119)4.29722088
24G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.26411458
25response to peptidoglycan (GO:0032494)4.24686155
26detection of other organism (GO:0098543)4.19647922
27detection of bacterium (GO:0016045)4.07835288
28B cell receptor signaling pathway (GO:0050853)4.04827351
29positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.01906916
30antigen processing and presentation of endogenous antigen (GO:0019883)3.99557868
31regulation of antigen processing and presentation (GO:0002577)3.99163902
32positive regulation of monocyte chemotaxis (GO:0090026)3.94090583
33regulation of hypersensitivity (GO:0002883)3.93404265
34detection of molecule of bacterial origin (GO:0032490)3.88445663
35detection of external biotic stimulus (GO:0098581)3.83080539
36negative regulation of granulocyte differentiation (GO:0030853)3.78983634
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.77629563
38T-helper 1 type immune response (GO:0042088)3.74770041
39positive regulation of B cell differentiation (GO:0045579)3.74538980
40positive regulation of leukocyte degranulation (GO:0043302)3.74070729
41myeloid dendritic cell activation (GO:0001773)3.69746623
42positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.68443316
43positive regulation of interferon-beta production (GO:0032728)3.67442213
44myeloid dendritic cell differentiation (GO:0043011)3.64192368
45myeloid leukocyte activation (GO:0002274)3.63901872
46positive regulation of chemokine secretion (GO:0090197)3.63209525
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62031276
48response to host immune response (GO:0052572)3.60305279
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.60305279
50regulation of monocyte chemotaxis (GO:0090025)3.58711430
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.55376289
52interferon-gamma-mediated signaling pathway (GO:0060333)3.55271047
53regulation of mast cell degranulation (GO:0043304)3.55157264
54cellular response to interferon-gamma (GO:0071346)3.54651459
55cellular response to interferon-beta (GO:0035458)3.54520108
56regulation of leukocyte degranulation (GO:0043300)3.54008812
57negative regulation of cell killing (GO:0031342)3.53751155
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53751155
59cellular response to exogenous dsRNA (GO:0071360)3.52302248
60cellular response to zinc ion (GO:0071294)3.52278907
61response to muramyl dipeptide (GO:0032495)3.49954767
62regulation of B cell differentiation (GO:0045577)3.48294370
63regulation of mast cell activation (GO:0033003)3.45603463
64positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.45539111
65detection of biotic stimulus (GO:0009595)3.42926503
66regulation of mast cell activation involved in immune response (GO:0033006)3.42527106
67negative regulation of mast cell activation (GO:0033004)3.41285309
68positive regulation of mast cell degranulation (GO:0043306)3.41175964
69positive regulation of mast cell activation involved in immune response (GO:0033008)3.41175964
70positive regulation of cellular amide metabolic process (GO:0034250)3.41110074
71positive regulation of type 2 immune response (GO:0002830)3.40606744
72defense response to protozoan (GO:0042832)3.40468230
73pinocytosis (GO:0006907)3.38339803
74positive regulation of interleukin-12 production (GO:0032735)3.36512993
75B cell mediated immunity (GO:0019724)3.34980894
76mature B cell differentiation involved in immune response (GO:0002313)3.34785201
77purinergic nucleotide receptor signaling pathway (GO:0035590)3.32435291
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31907485
79dendritic cell differentiation (GO:0097028)3.31778323
80mast cell activation (GO:0045576)3.31079545
81positive regulation of mast cell activation (GO:0033005)3.30214404
82I-kappaB phosphorylation (GO:0007252)3.29661149
83regulation of interleukin-12 biosynthetic process (GO:0045075)3.29427149
84response to interferon-gamma (GO:0034341)3.24195674
85positive regulation of gamma-delta T cell activation (GO:0046645)3.24014423
86cellular extravasation (GO:0045123)3.23799903
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23489931
88response to host (GO:0075136)3.23489931
89response to host defenses (GO:0052200)3.23489931
90eosinophil chemotaxis (GO:0048245)3.22971679
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.20595919
92negative regulation of B cell proliferation (GO:0030889)3.20048554
93leukocyte mediated cytotoxicity (GO:0001909)3.18440585
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17691287
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.17691287
96cellular response to type I interferon (GO:0071357)3.14544440
97type I interferon signaling pathway (GO:0060337)3.14544440
98phagocytosis, engulfment (GO:0006911)3.13955992
99regulation of gamma-delta T cell activation (GO:0046643)3.13480001
100positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.12231213
101response to type I interferon (GO:0034340)3.11781440
102regulation of inflammatory response to antigenic stimulus (GO:0002861)3.10670371
103production of molecular mediator involved in inflammatory response (GO:0002532)3.10557795
104regulation of T-helper 2 cell differentiation (GO:0045628)3.10338203
105germinal center formation (GO:0002467)3.09101848
106positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.07290452
107positive regulation of lymphocyte migration (GO:2000403)3.07091294
108monocyte chemotaxis (GO:0002548)3.06716390
109regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06175906
110response to protozoan (GO:0001562)3.04800598
111negative regulation of phagocytosis (GO:0050765)3.03127343
112G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.02497862
113negative regulation of cytokine production involved in immune response (GO:0002719)3.00065990
114T cell costimulation (GO:0031295)2.99718726
115regulation of T cell tolerance induction (GO:0002664)2.98622114
116mature B cell differentiation (GO:0002335)2.98075552
117negative regulation of myeloid cell apoptotic process (GO:0033033)2.97834880
118negative regulation of interleukin-17 production (GO:0032700)2.97569529
119regulation of T-helper 1 cell differentiation (GO:0045625)2.97434341
120positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.96170796
121positive regulation of B cell mediated immunity (GO:0002714)2.95916164
122positive regulation of immunoglobulin mediated immune response (GO:0002891)2.95916164
123lymphocyte costimulation (GO:0031294)2.95265805
124positive thymic T cell selection (GO:0045059)2.95217964
125regulation of germinal center formation (GO:0002634)2.94482628
126regulation of interferon-gamma biosynthetic process (GO:0045072)2.93137038
127glycosphingolipid catabolic process (GO:0046479)2.93130684
128positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92825049
129adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.91671032
130regulation of tolerance induction (GO:0002643)2.91510293
131T cell migration (GO:0072678)2.88851553
132Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86565606
133regulation of interleukin-12 production (GO:0032655)2.86441303
134histamine secretion (GO:0001821)2.86215122
135eosinophil migration (GO:0072677)2.85106848
136negative regulation of growth of symbiont in host (GO:0044130)2.85076520
137negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.85076520
138modulation of growth of symbiont involved in interaction with host (GO:0044144)2.85076520
139regulation of growth of symbiont in host (GO:0044126)2.85076520
140regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85013728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse7.30391722
2* IRF8_22096565_ChIP-ChIP_GC-B_Human6.67658512
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.53447459
4* IRF8_27001747_Chip-Seq_BMDM_Mouse5.24606861
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.52598154
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.52532857
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97634360
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.77575937
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.75024414
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.56086230
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.08500595
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.01378762
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.96698522
14* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90387545
15* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.89126740
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84429808
17SPI1_23547873_ChIP-Seq_NB4_Human2.60721784
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53455819
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52288298
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21298058
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.21095487
22RUNX_20019798_ChIP-Seq_JUKART_Human2.19458320
23VDR_24763502_ChIP-Seq_THP-1_Human2.11589487
24* SPI1_23127762_ChIP-Seq_K562_Human2.11189326
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09684956
26* SCL_19346495_ChIP-Seq_HPC-7_Human2.09495667
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06257159
28MYB_26560356_Chip-Seq_TH2_Human2.01511208
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.98651005
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.96961577
31VDR_21846776_ChIP-Seq_THP-1_Human1.95472927
32GATA1_22025678_ChIP-Seq_K562_Human1.93876863
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93532710
34PU_27001747_Chip-Seq_BMDM_Mouse1.90636460
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83840939
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82084701
37* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74715864
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74087295
39MAF_26560356_Chip-Seq_TH1_Human1.72427900
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70226371
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69258092
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68805604
43VDR_24787735_ChIP-Seq_THP-1_Human1.67349602
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61864343
45MYB_26560356_Chip-Seq_TH1_Human1.61580038
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61240582
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57223429
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54586355
49* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49435061
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38759318
51EGR1_19032775_ChIP-ChIP_M12_Human1.38503516
52* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38105817
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37210449
54CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36257109
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35469654
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29599226
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26522037
58MYC_22102868_ChIP-Seq_BL_Human1.26303456
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24958988
60GATA3_27048872_Chip-Seq_THYMUS_Human1.24213039
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22354364
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22046489
63GATA3_26560356_Chip-Seq_TH2_Human1.20806719
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20637006
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19147227
66UTX_26944678_Chip-Seq_JUKART_Human1.18344945
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14120536
68BCL6_27268052_Chip-Seq_Bcells_Human1.11632351
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10802645
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05055809
71STAT1_20625510_ChIP-Seq_HELA_Human1.04868202
72LXR_22292898_ChIP-Seq_THP-1_Human1.04521459
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03508954
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.00365458
75TCF7_22412390_ChIP-Seq_EML_Mouse0.99852001
76BCOR_27268052_Chip-Seq_Bcells_Human0.93041523
77* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92660821
78CIITA_25753668_ChIP-Seq_RAJI_Human0.92612221
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.91860824
80PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91831609
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89461057
82HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88169002
83MAF_26560356_Chip-Seq_TH2_Human0.87667755
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87047988
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83243499
86* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83007360
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79181034
88* SPI1_20517297_ChIP-Seq_HL60_Human0.79080273
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78424135
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78353969
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.76333808
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75681115
93* SMRT_27268052_Chip-Seq_Bcells_Human0.74974646
94P300_27268052_Chip-Seq_Bcells_Human0.73994903
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72653588
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71991101
97GATA2_19941826_ChIP-Seq_K562_Human0.69876302
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69177668
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67009850
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.66826853
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.66804643
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64624484
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.64201446
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.62605744
105KDM2B_26808549_Chip-Seq_DND41_Human0.60913583
106TFEB_21752829_ChIP-Seq_HELA_Human0.59976305
107GATA1_19941826_ChIP-Seq_K562_Human0.57480060
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.53377824
109ELF1_17652178_ChIP-ChIP_JURKAT_Human0.50488519
110CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49949205
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.48477204
112* GATA3_26560356_Chip-Seq_TH1_Human0.47771264
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46980654
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.46889949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.74650675
2MP0002148_abnormal_hypersensitivity_rea3.89760873
3MP0006082_CNS_inflammation3.52727840
4MP0003436_decreased_susceptibility_to3.45093764
5MP0005000_abnormal_immune_tolerance3.33575303
6MP0005058_abnormal_lysosome_morphology3.31617513
7MP0002419_abnormal_innate_immunity3.25703019
8MP0005671_abnormal_response_to3.24679347
9MP0003303_peritoneal_inflammation3.10255285
10* MP0001800_abnormal_humoral_immune2.99680025
11* MP0002452_abnormal_antigen_presenting2.99323696
12MP0001790_abnormal_immune_system2.98844387
13MP0005387_immune_system_phenotype2.98844387
14MP0009785_altered_susceptibility_to2.84289824
15MP0005025_abnormal_response_to2.82565333
16* MP0002723_abnormal_immune_serum2.71620307
17MP0003191_abnormal_cellular_cholesterol2.70035407
18MP0000685_abnormal_immune_system2.60118637
19* MP0001819_abnormal_immune_cell2.49386726
20MP0005464_abnormal_platelet_physiology2.48558601
21* MP0002420_abnormal_adaptive_immunity2.48228503
22MP0003172_abnormal_lysosome_physiology2.37833608
23MP0003724_increased_susceptibility_to2.10212905
24MP0001853_heart_inflammation2.05301749
25MP0004510_myositis2.01774998
26MP0002405_respiratory_system_inflammati1.88454485
27* MP0000716_abnormal_immune_system1.87843093
28MP0003806_abnormal_nucleotide_metabolis1.87507939
29MP0001533_abnormal_skeleton_physiology1.85219608
30MP0001845_abnormal_inflammatory_respons1.85001516
31MP0009840_abnormal_foam_cell1.81907073
32MP0003075_altered_response_to1.81847189
33* MP0002398_abnormal_bone_marrow1.76638979
34MP0003690_abnormal_glial_cell1.74884362
35MP0005310_abnormal_salivary_gland1.73095024
36MP0002166_altered_tumor_susceptibility1.71402230
37MP0000689_abnormal_spleen_morphology1.65651354
38MP0000343_altered_response_to1.65555970
39MP0008469_abnormal_protein_level1.65140172
40MP0009333_abnormal_splenocyte_physiolog1.56410599
41MP0002006_tumorigenesis1.52156027
42* MP0002429_abnormal_blood_cell1.50743690
43MP0009764_decreased_sensitivity_to1.42703518
44MP0003183_abnormal_peptide_metabolism1.41438905
45MP0002722_abnormal_immune_system1.41384418
46MP0010155_abnormal_intestine_physiology1.39899634
47MP0002998_abnormal_bone_remodeling1.37014512
48MP0005166_decreased_susceptibility_to1.36829720
49MP0002139_abnormal_hepatobiliary_system1.34953225
50MP0004947_skin_inflammation1.33498459
51MP0002396_abnormal_hematopoietic_system1.33066711
52MP0000465_gastrointestinal_hemorrhage1.29397966
53MP0000604_amyloidosis1.24385049
54MP0000858_altered_metastatic_potential1.23879343
55MP0003448_altered_tumor_morphology1.22755435
56MP0003300_gastrointestinal_ulcer1.15671281
57MP0005451_abnormal_body_composition1.12574369
58MP0004883_abnormal_blood_vessel1.08066868
59MP0000249_abnormal_blood_vessel0.97106942
60MP0002736_abnormal_nociception_after0.95124581
61MP0005174_abnormal_tail_pigmentation0.94403390
62MP0005164_abnormal_response_to0.92677296
63MP0002277_abnormal_respiratory_mucosa0.92213395
64MP0003763_abnormal_thymus_physiology0.91327104
65MP0002138_abnormal_hepatobiliary_system0.88785003
66MP0000015_abnormal_ear_pigmentation0.87121517
67MP0002933_joint_inflammation0.86848181
68MP0001986_abnormal_taste_sensitivity0.86252001
69MP0001545_abnormal_hematopoietic_system0.86021471
70MP0005397_hematopoietic_system_phenotyp0.86021471
71MP0001663_abnormal_digestive_system0.84886863
72MP0010307_abnormal_tumor_latency0.84465329
73MP0003828_pulmonary_edema0.81599266
74MP0001851_eye_inflammation0.81406228
75MP0004782_abnormal_surfactant_physiolog0.80429661
76MP0003656_abnormal_erythrocyte_physiolo0.78327783
77MP0005390_skeleton_phenotype0.78119910
78MP0009763_increased_sensitivity_to0.77191897
79MP0000569_abnormal_digit_pigmentation0.76486314
80MP0001873_stomach_inflammation0.75952232
81MP0000920_abnormal_myelination0.75068814
82MP0002136_abnormal_kidney_physiology0.73833899
83MP0002254_reproductive_system_inflammat0.73816244
84MP0002928_abnormal_bile_duct0.71737669
85MP0008260_abnormal_autophagy0.71501704
86MP0004808_abnormal_hematopoietic_stem0.71434906
87MP0000767_abnormal_smooth_muscle0.70128566
88MP0008873_increased_physiological_sensi0.69760662
89MP0001542_abnormal_bone_strength0.69022119
90MP0000703_abnormal_thymus_morphology0.68922681
91MP0003045_fibrosis0.68602318
92MP0001915_intracranial_hemorrhage0.66972722
93MP0001968_abnormal_touch/_nociception0.66393383
94MP0002332_abnormal_exercise_endurance0.65235736
95MP0008004_abnormal_stomach_pH0.64848910
96MP0003279_aneurysm0.64712395
97MP0003866_abnormal_defecation0.64636325
98MP0005165_increased_susceptibility_to0.64441262
99MP0005075_abnormal_melanosome_morpholog0.64037760
100MP0002132_abnormal_respiratory_system0.63392652
101MP0003795_abnormal_bone_structure0.62523202
102MP0009278_abnormal_bone_marrow0.62408057
103MP0000490_abnormal_crypts_of0.61576008
104MP0003453_abnormal_keratinocyte_physiol0.58489884
105MP0005319_abnormal_enzyme/_coenzyme0.58294201
106MP0006054_spinal_hemorrhage0.58217534
107MP0002090_abnormal_vision0.56602456
108MP0005535_abnormal_body_temperature0.56223928
109MP0005167_abnormal_blood-brain_barrier0.54356334
110MP0009765_abnormal_xenobiotic_induced0.53623413
111MP0005647_abnormal_sex_gland0.52661563
112MP0008874_decreased_physiological_sensi0.52404356
113MP0005584_abnormal_enzyme/coenzyme_acti0.52285076
114MP0000371_diluted_coat_color0.51738858
115MP0006036_abnormal_mitochondrial_physio0.50802994

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.36253603
2Recurrent abscess formation (HP:0002722)6.98222169
3Recurrent bacterial skin infections (HP:0005406)6.71396396
4Glomerulonephritis (HP:0000099)6.01742214
5Eczematoid dermatitis (HP:0000976)5.58955274
6Abnormality of glycolipid metabolism (HP:0010969)4.61507096
7Abnormality of liposaccharide metabolism (HP:0010968)4.61507096
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.61507096
9Recurrent gram-negative bacterial infections (HP:0005420)4.42827793
10Agnosia (HP:0010524)4.38428684
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.38179447
12Elevated erythrocyte sedimentation rate (HP:0003565)4.12352544
13Vacuolated lymphocytes (HP:0001922)4.11302352
14Recurrent skin infections (HP:0001581)4.11126843
15Increased cerebral lipofuscin (HP:0011813)4.08761174
16Complement deficiency (HP:0004431)4.08596014
17Disinhibition (HP:0000734)4.07340547
18Increased neuronal autofluorescent lipopigment (HP:0002074)4.02581798
19Abnormality of macrophages (HP:0004311)3.92648756
20Axonal loss (HP:0003447)3.90007206
21Mediastinal lymphadenopathy (HP:0100721)3.78640413
22Myositis (HP:0100614)3.76829349
23Abnormality of complement system (HP:0005339)3.71665379
24Dysostosis multiplex (HP:0000943)3.58937101
25Chronic obstructive pulmonary disease (HP:0006510)3.53029742
26Obstructive lung disease (HP:0006536)3.53029742
27Nephritis (HP:0000123)3.44132527
28Recurrent viral infections (HP:0004429)3.42695563
29Basal ganglia calcification (HP:0002135)3.36177499
30Cellulitis (HP:0100658)3.35324085
31Recurrent fungal infections (HP:0002841)3.33724059
32Loss of speech (HP:0002371)3.32516532
33Vasculitis (HP:0002633)3.24126863
34Colitis (HP:0002583)3.21748839
35Meningitis (HP:0001287)3.14976259
36Agammaglobulinemia (HP:0004432)3.06512211
37Gingivitis (HP:0000230)3.05901814
38Autoimmune thrombocytopenia (HP:0001973)3.03060324
39Orchitis (HP:0100796)2.98538986
40Purpura (HP:0000979)2.88140543
41Hematochezia (HP:0002573)2.87676644
42Recurrent pneumonia (HP:0006532)2.85394314
43Inflammation of the large intestine (HP:0002037)2.81445167
44Spontaneous hematomas (HP:0007420)2.80424750
45Recurrent cutaneous fungal infections (HP:0011370)2.78531320
46Chronic mucocutaneous candidiasis (HP:0002728)2.78531320
47Optic neuritis (HP:0100653)2.76228999
48Retrobulbar optic neuritis (HP:0100654)2.76228999
49Pustule (HP:0200039)2.75030957
50Osteomyelitis (HP:0002754)2.74661790
51Upper motor neuron abnormality (HP:0002127)2.72666342
52Chronic otitis media (HP:0000389)2.69045417
53Gastrointestinal stroma tumor (HP:0100723)2.66422101
54IgM deficiency (HP:0002850)2.62396211
55Encephalitis (HP:0002383)2.61798421
56Keratoconjunctivitis sicca (HP:0001097)2.60537669
57Urinary glycosaminoglycan excretion (HP:0003541)2.60023478
58Mucopolysacchariduria (HP:0008155)2.60023478
59Gastrointestinal inflammation (HP:0004386)2.59839062
60Petechiae (HP:0000967)2.59252345
61Chest pain (HP:0100749)2.57347006
62Periodontitis (HP:0000704)2.57258029
63Stomatitis (HP:0010280)2.57151763
64Recurrent lower respiratory tract infections (HP:0002783)2.54773190
65Interstitial pulmonary disease (HP:0006530)2.54144832
66Increased serum ferritin (HP:0003281)2.51642703
67Chronic diarrhea (HP:0002028)2.50434198
68Restrictive lung disease (HP:0002091)2.50118435
69Gangrene (HP:0100758)2.49189526
70Hepatosplenomegaly (HP:0001433)2.47691152
71Abnormality of the pleura (HP:0002103)2.46267541
72Polyneuropathy (HP:0001271)2.44130213
73Pulmonary infiltrates (HP:0002113)2.43680207
74Abnormality of the vasculature of the conjunctiva (HP:0008054)2.42471307
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41524381
76Abnormality of polysaccharide metabolism (HP:0011012)2.41524381
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41524381
78Gastrointestinal infarctions (HP:0005244)2.41140076
79Keratoconjunctivitis (HP:0001096)2.40079776
80Pathologic fracture (HP:0002756)2.37327009
81Increased IgM level (HP:0003496)2.36737381
82Pulmonary embolism (HP:0002204)2.35220677
83Thick nail (HP:0001805)2.33481610
84Epistaxis (HP:0000421)2.29983930
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.29000142
86Prostate neoplasm (HP:0100787)2.27791116
87Progressive neurologic deterioration (HP:0002344)2.26267584
88T lymphocytopenia (HP:0005403)2.23265192
89Amyloidosis (HP:0011034)2.22794228
90Thrombocytosis (HP:0001894)2.21987807
91Inappropriate behavior (HP:0000719)2.21488205
92Leukocytosis (HP:0001974)2.20744727
93Eosinophilia (HP:0001880)2.20552828
94Panhypogammaglobulinemia (HP:0003139)2.19938471
95Myocardial infarction (HP:0001658)2.18548622
96Abnormality of T cell number (HP:0011839)2.16333927
97Increased IgE level (HP:0003212)2.14308969
98Memory impairment (HP:0002354)2.14298159
99Recurrent bronchitis (HP:0002837)2.12445363
100Urticaria (HP:0001025)2.12039122
101Abnormality of iron homeostasis (HP:0011031)2.11206233
102Skin rash (HP:0000988)2.09984547
103Abnormality of the prostate (HP:0008775)2.09781586
104Glomerulopathy (HP:0100820)2.07907001
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07639019
106Pulmonary fibrosis (HP:0002206)2.07255930
107Gingival bleeding (HP:0000225)2.07098550
108Lymphopenia (HP:0001888)2.05712887
109Sepsis (HP:0100806)2.02418663
110Abnormality of cells of the lymphoid lineage (HP:0012140)2.01790254
111Hypergammaglobulinemia (HP:0010702)2.00240290
112Retinal atrophy (HP:0001105)1.99611522
113Abnormality of B cell number (HP:0010975)1.99302165
114Spondylolisthesis (HP:0003302)1.99256621
115Acrocyanosis (HP:0001063)1.99056763
116Recurrent sinusitis (HP:0011108)1.98455933
117Arterial thrombosis (HP:0004420)1.98133743
118Thyroiditis (HP:0100646)1.94700746
119Abnormality of T cell physiology (HP:0011840)1.94420360
120Mutism (HP:0002300)1.92521388
121Hemoptysis (HP:0002105)1.91961637
122Emphysema (HP:0002097)1.91032595
123Osteolytic defects of the hand bones (HP:0009699)1.89312960
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.89312960
125Personality changes (HP:0000751)1.88468136
126Arthralgia (HP:0002829)1.88188541
127Thoracic kyphosis (HP:0002942)1.84253321
128Poor head control (HP:0002421)1.83270097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.85259938
2TGFBR24.39227556
3RIPK44.06251935
4MAP3K143.83064870
5MAP4K13.43320829
6TYK23.27628507
7IRAK43.21927430
8CSF1R2.81908287
9TBK12.70746202
10IRAK32.67938725
11KIT2.56340957
12GRK72.55592209
13CDK192.17848925
14IKBKB2.05980051
15SYK1.93256942
16JAK11.87478419
17ERN11.86298444
18NEK91.81218871
19BTK1.68817533
20IKBKE1.64105611
21STK101.63010492
22LYN1.62188250
23JAK31.60646666
24MAP3K131.59893792
25TXK1.58859073
26TAOK21.57464839
27ZAP701.56767128
28MATK1.50001943
29TEC1.49127605
30PRPF4B1.47156512
31CSK1.40859268
32MAP3K111.40858869
33CLK11.37382426
34HCK1.36461480
35TNK21.36299691
36FES1.31633843
37TAOK11.21587624
38LCK1.19683329
39ITK1.15074088
40MAP3K121.14930430
41JAK21.07215881
42MOS1.06185333
43PDK21.03244095
44TAOK31.03191920
45TLK10.99284961
46CHUK0.98151324
47BMPR20.96398456
48PIM20.95868273
49MARK30.92778939
50MAP2K30.91270394
51YES10.89838777
52SIK30.89233859
53ADRBK20.86625611
54EIF2AK20.84479284
55SCYL20.84414579
56TESK20.79156882
57PIM10.78820859
58MAPK120.78405877
59MST40.77135388
60PRKCD0.73135564
61MAP3K10.70956558
62PDK10.69803359
63DAPK30.68452707
64MAP3K50.68442955
65LRRK20.67402715
66FLT30.67296043
67GRK50.64841000
68SIK20.63870489
69CDC42BPA0.62496471
70NME20.62038731
71EIF2AK30.61594514
72DDR20.61372975
73MAPK150.60003665
74ARAF0.58779595
75EPHB10.58630251
76FGR0.58543937
77GRK60.58052502
78MAPKAPK20.55555602
79KDR0.54186282
80RPS6KA40.52167297
81ABL10.51315858
82CAMKK20.50505064
83FGFR30.49910626
84MST1R0.49757185
85MAPK40.49691205
86PRKCQ0.48821226
87EGFR0.47916978
88RPS6KA60.46204047
89CDK40.42388541
90MAPK70.41772887
91STK40.41698840
92IGF1R0.40901461
93PKN20.40806910
94TRPM70.40567957
95PBK0.40368096
96CDK60.40293616
97PAK40.39006991
98ACVR1B0.38246411
99RPS6KL10.37663406
100RPS6KC10.37663406
101ABL20.37436162
102TSSK60.37397624
103PDPK10.36741356
104CAMK1D0.35964155
105MAP2K60.34344063
106CAMKK10.33534377
107PKN10.33384891
108PIK3CG0.33108500
109RPS6KA20.32695292
110DAPK10.32290355
111FYN0.29968028
112HIPK20.29456619
113STK240.28062302
114IRAK20.26463685
115VRK10.26061458
116ILK0.25535950
117MAP3K30.23536409
118BMX0.23228297
119NEK60.22945693
120MAP3K80.21977295
121PAK10.21756828
122CCNB10.20953351
123IRAK10.20908732
124DAPK20.20536334
125INSR0.19034112

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.08614379
2Other glycan degradation_Homo sapiens_hsa005113.18868430
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.05326872
4Leishmaniasis_Homo sapiens_hsa051403.01780766
5Osteoclast differentiation_Homo sapiens_hsa043802.74658489
6Lysosome_Homo sapiens_hsa041422.73896212
7B cell receptor signaling pathway_Homo sapiens_hsa046622.65586298
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.65225565
9Pertussis_Homo sapiens_hsa051332.52341542
10Antigen processing and presentation_Homo sapiens_hsa046122.28964683
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.26059918
12Tuberculosis_Homo sapiens_hsa051522.21479107
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.05109991
14Graft-versus-host disease_Homo sapiens_hsa053321.95475464
15Measles_Homo sapiens_hsa051621.95368166
16Primary immunodeficiency_Homo sapiens_hsa053401.94709293
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93957282
18Legionellosis_Homo sapiens_hsa051341.91798433
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.91784252
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87428461
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85239447
22Allograft rejection_Homo sapiens_hsa053301.80352786
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75070565
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64616249
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64225794
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63334092
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62023010
28Phagosome_Homo sapiens_hsa041451.59453480
29Chemokine signaling pathway_Homo sapiens_hsa040621.59416933
30Salmonella infection_Homo sapiens_hsa051321.57762474
31Influenza A_Homo sapiens_hsa051641.57329183
32Toxoplasmosis_Homo sapiens_hsa051451.56330355
33Hematopoietic cell lineage_Homo sapiens_hsa046401.54416712
34Rheumatoid arthritis_Homo sapiens_hsa053231.53924890
35Malaria_Homo sapiens_hsa051441.51694159
36Apoptosis_Homo sapiens_hsa042101.33882361
37Herpes simplex infection_Homo sapiens_hsa051681.30887078
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29395842
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24282433
40Shigellosis_Homo sapiens_hsa051311.20150335
41Complement and coagulation cascades_Homo sapiens_hsa046101.19749324
42Asthma_Homo sapiens_hsa053101.16596813
43Viral myocarditis_Homo sapiens_hsa054161.14944744
44Prion diseases_Homo sapiens_hsa050201.09941360
45TNF signaling pathway_Homo sapiens_hsa046681.06716811
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.05448693
47African trypanosomiasis_Homo sapiens_hsa051431.04760789
48Hepatitis B_Homo sapiens_hsa051611.00619491
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91274844
50Type I diabetes mellitus_Homo sapiens_hsa049400.89201515
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88675282
52Autoimmune thyroid disease_Homo sapiens_hsa053200.87222895
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86985834
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84736864
55Renin-angiotensin system_Homo sapiens_hsa046140.81934203
56Platelet activation_Homo sapiens_hsa046110.81220320
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81186349
58Collecting duct acid secretion_Homo sapiens_hsa049660.79246499
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.76819055
60T cell receptor signaling pathway_Homo sapiens_hsa046600.76122687
61Pancreatic cancer_Homo sapiens_hsa052120.75472171
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72821979
63Hepatitis C_Homo sapiens_hsa051600.72599268
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.68740060
65Epstein-Barr virus infection_Homo sapiens_hsa051690.67562804
66Chronic myeloid leukemia_Homo sapiens_hsa052200.63192286
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59084620
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56919113
69Acute myeloid leukemia_Homo sapiens_hsa052210.55528909
70Endocytosis_Homo sapiens_hsa041440.48830083
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46745625
72Systemic lupus erythematosus_Homo sapiens_hsa053220.41814535
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.41220152
74Amoebiasis_Homo sapiens_hsa051460.40758868
75N-Glycan biosynthesis_Homo sapiens_hsa005100.32321698
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31095704
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30690286
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30189584
79Prolactin signaling pathway_Homo sapiens_hsa049170.29890655
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29755233
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29479423
82Oxidative phosphorylation_Homo sapiens_hsa001900.29396779
83Viral carcinogenesis_Homo sapiens_hsa052030.29210853
84Arachidonic acid metabolism_Homo sapiens_hsa005900.28468689
85Sphingolipid metabolism_Homo sapiens_hsa006000.27727838
86Bladder cancer_Homo sapiens_hsa052190.25587541
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24346117
88HIF-1 signaling pathway_Homo sapiens_hsa040660.24247738
89Ether lipid metabolism_Homo sapiens_hsa005650.23587717
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23342634
91Vibrio cholerae infection_Homo sapiens_hsa051100.23250597
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20861771
93Mineral absorption_Homo sapiens_hsa049780.20051900
94MAPK signaling pathway_Homo sapiens_hsa040100.18640840
95VEGF signaling pathway_Homo sapiens_hsa043700.17740765
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.17092511
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16944894
98Non-small cell lung cancer_Homo sapiens_hsa052230.16691132
99HTLV-I infection_Homo sapiens_hsa051660.14935746
100Colorectal cancer_Homo sapiens_hsa052100.14589087
101Base excision repair_Homo sapiens_hsa034100.14182698
102ABC transporters_Homo sapiens_hsa020100.13814480
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12730739
104Regulation of autophagy_Homo sapiens_hsa041400.12118549
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.11388506
106Notch signaling pathway_Homo sapiens_hsa043300.11295460
107Small cell lung cancer_Homo sapiens_hsa052220.11001618
108Galactose metabolism_Homo sapiens_hsa000520.10109151
109Proteasome_Homo sapiens_hsa030500.05458980
110Parkinsons disease_Homo sapiens_hsa050120.05131085
111Renal cell carcinoma_Homo sapiens_hsa052110.01646996
112Pentose phosphate pathway_Homo sapiens_hsa000300.00303776
113Alzheimers disease_Homo sapiens_hsa05010-0.0255224
114GnRH signaling pathway_Homo sapiens_hsa04912-0.0240815
115Sulfur metabolism_Homo sapiens_hsa00920-0.0038760

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