LY96

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.10017551
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.08555499
3negative regulation of interleukin-12 production (GO:0032695)5.06375795
4daunorubicin metabolic process (GO:0044597)4.81204098
5polyketide metabolic process (GO:0030638)4.81204098
6doxorubicin metabolic process (GO:0044598)4.81204098
7positive regulation by symbiont of host defense response (GO:0052509)4.71622927
8modulation by symbiont of host defense response (GO:0052031)4.71622927
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.71622927
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.71622927
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.71622927
12modulation by symbiont of host immune response (GO:0052553)4.71622927
13T-helper 1 type immune response (GO:0042088)4.57052708
14neutrophil activation (GO:0042119)4.50018823
15response to peptidoglycan (GO:0032494)4.48204732
16granulocyte activation (GO:0036230)4.48008022
17positive regulation of gamma-delta T cell activation (GO:0046645)4.36604487
18regulation of activation of Janus kinase activity (GO:0010533)3.97350364
19macrophage activation involved in immune response (GO:0002281)3.96324438
20* detection of molecule of bacterial origin (GO:0032490)3.95715186
21immunoglobulin mediated immune response (GO:0016064)3.95078535
22positive regulation of interferon-alpha production (GO:0032727)3.94962426
23positive regulation of mast cell activation (GO:0033005)3.88173499
24negative regulation of cell killing (GO:0031342)3.87139601
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87139601
26respiratory burst (GO:0045730)3.86499426
27positive regulation of mast cell activation involved in immune response (GO:0033008)3.84624637
28positive regulation of mast cell degranulation (GO:0043306)3.84624637
29regulation of RIG-I signaling pathway (GO:0039535)3.80020495
30eosinophil chemotaxis (GO:0048245)3.79643856
31superoxide anion generation (GO:0042554)3.73942362
32regulation of interferon-alpha production (GO:0032647)3.70180168
33cellular extravasation (GO:0045123)3.70025141
34regulation of T-helper 1 cell differentiation (GO:0045625)3.69741155
35negative regulation of interleukin-17 production (GO:0032700)3.68645011
36type I interferon signaling pathway (GO:0060337)3.67289322
37cellular response to type I interferon (GO:0071357)3.67289322
38cellular response to zinc ion (GO:0071294)3.66071718
39production of molecular mediator involved in inflammatory response (GO:0002532)3.63554616
40cellular response to interferon-beta (GO:0035458)3.60607942
41response to type I interferon (GO:0034340)3.60583124
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.58544291
43hydrogen peroxide biosynthetic process (GO:0050665)3.47964794
44positive regulation of cellular amide metabolic process (GO:0034250)3.47872218
45monocyte chemotaxis (GO:0002548)3.47587400
46macrophage activation (GO:0042116)3.45290860
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.44212354
48* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44057421
49regulation of mast cell activation involved in immune response (GO:0033006)3.43912458
50* detection of external biotic stimulus (GO:0098581)3.38670453
51response to interferon-beta (GO:0035456)3.37614453
52regulation of mast cell activation (GO:0033003)3.36727851
53positive regulation of monocyte chemotaxis (GO:0090026)3.34738624
54positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.33847913
55myeloid dendritic cell differentiation (GO:0043011)3.33174658
56microglial cell activation (GO:0001774)3.32911539
57eosinophil migration (GO:0072677)3.32373580
58myeloid cell activation involved in immune response (GO:0002275)3.32036782
59defense response to protozoan (GO:0042832)3.30097439
60natural killer cell mediated cytotoxicity (GO:0042267)3.29961426
61natural killer cell mediated immunity (GO:0002228)3.29961426
62positive regulation of leukocyte degranulation (GO:0043302)3.28154937
63detection of other organism (GO:0098543)3.25595613
64positive regulation of antigen processing and presentation (GO:0002579)3.25316093
65positive regulation of interleukin-12 production (GO:0032735)3.25268616
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24316676
67response to host immune response (GO:0052572)3.24316676
68regulation of B cell receptor signaling pathway (GO:0050855)3.23902144
69positive regulation of natural killer cell differentiation (GO:0032825)3.22938923
70interferon-gamma-mediated signaling pathway (GO:0060333)3.21544755
71myeloid dendritic cell activation (GO:0001773)3.20296782
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19906025
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.19786265
74glycosphingolipid catabolic process (GO:0046479)3.19283901
75positive regulation of type 2 immune response (GO:0002830)3.18694743
76regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18350986
77negative regulation of viral genome replication (GO:0045071)3.18258404
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.16688093
79negative regulation of cytokine production involved in immune response (GO:0002719)3.16679373
80reactive oxygen species biosynthetic process (GO:1903409)3.15298654
81regulation of T cell tolerance induction (GO:0002664)3.15267753
82regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.15251743
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14497545
84amino sugar catabolic process (GO:0046348)3.12607006
85positive regulation of chemokine biosynthetic process (GO:0045080)3.12166802
86regulation of interleukin-17 production (GO:0032660)3.11886335
87regulation of interferon-beta biosynthetic process (GO:0045357)3.11352158
88* detection of biotic stimulus (GO:0009595)3.11337377
89positive regulation of interferon-beta production (GO:0032728)3.11286384
90positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11109833
91cellular response to thyroid hormone stimulus (GO:0097067)3.10658737
92regulation of leukocyte degranulation (GO:0043300)3.10643425
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07441456
94B cell mediated immunity (GO:0019724)3.06202912
95regulation of mononuclear cell migration (GO:0071675)3.04014230
96oligosaccharide catabolic process (GO:0009313)3.03714413
97cellular response to interferon-gamma (GO:0071346)3.03524736
98positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.03177077
99myeloid leukocyte activation (GO:0002274)3.00332516
100regulation of tolerance induction (GO:0002643)2.99494937
101cellular response to exogenous dsRNA (GO:0071360)2.99304813
102leukocyte aggregation (GO:0070486)2.98211510
103regulation of gamma-delta T cell activation (GO:0046643)2.97568553
104regulation of interferon-gamma biosynthetic process (GO:0045072)2.97303623
105response to interferon-alpha (GO:0035455)2.97167038
106positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.94767102
107positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.94724095
108positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.93978340
109response to protozoan (GO:0001562)2.93918795
110germinal center formation (GO:0002467)2.93808796
111positive regulation of lymphocyte migration (GO:2000403)2.92934252
112positive regulation of macrophage differentiation (GO:0045651)2.92060271
113detection of bacterium (GO:0016045)2.90213695
114aminoglycoside antibiotic metabolic process (GO:0030647)2.90024066
115response to interferon-gamma (GO:0034341)2.89008875
116regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.88359425
117positive regulation of T-helper cell differentiation (GO:0045624)2.88307459
118endosome to pigment granule transport (GO:0043485)2.87718977
119endosome to melanosome transport (GO:0035646)2.87718977
120positive regulation of interleukin-17 production (GO:0032740)2.87695882
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87075936
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85953498
123glycolipid catabolic process (GO:0019377)2.85472283
124regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.84432565
125regulation of antigen processing and presentation (GO:0002577)2.83992956
126regulation of hypersensitivity (GO:0002883)2.83958069
127regulation of T-helper 2 cell differentiation (GO:0045628)2.83844065
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83439487
129response to host (GO:0075136)2.83439487
130response to host defenses (GO:0052200)2.83439487
131antigen processing and presentation of endogenous antigen (GO:0019883)2.83142694
132positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83011382
133regulation of type 2 immune response (GO:0002828)2.81611207
134NIK/NF-kappaB signaling (GO:0038061)2.81207820
135response to muramyl dipeptide (GO:0032495)2.81157819
136regulation of chemokine biosynthetic process (GO:0045073)2.80715186
137positive regulation of tumor necrosis factor production (GO:0032760)2.80624548
138positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80008361
139regulation of mast cell degranulation (GO:0043304)2.79591230
140lymphocyte chemotaxis (GO:0048247)2.78422123
141positive regulation of interleukin-10 production (GO:0032733)2.78374888
142regulation of fever generation (GO:0031620)2.77764697
143positive regulation of interleukin-6 production (GO:0032755)2.77594467
144negative regulation of myeloid cell apoptotic process (GO:0033033)2.76599987
145neutrophil chemotaxis (GO:0030593)2.76453657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.26448515
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.71120610
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.70535536
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.85755354
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.27115924
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.00081212
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.99741077
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57399887
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32647417
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.21825310
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17288671
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.03942918
13* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83901385
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.65494979
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59723147
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58585774
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50183554
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45345835
19SPI1_23547873_ChIP-Seq_NB4_Human2.16404344
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84276642
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84270462
22VDR_21846776_ChIP-Seq_THP-1_Human1.80488408
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.74428472
24* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65982339
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64282392
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62302138
27* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60533257
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.59964517
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57938264
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54776720
31SCL_19346495_ChIP-Seq_HPC-7_Human1.53826381
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52335661
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52274716
34* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50946450
35GATA1_22025678_ChIP-Seq_K562_Human1.50408904
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49220552
37VDR_24787735_ChIP-Seq_THP-1_Human1.47282720
38* PU_27001747_Chip-Seq_BMDM_Mouse1.46660505
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.46420768
40MYB_26560356_Chip-Seq_TH2_Human1.43809473
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43495689
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43362925
43RUNX_20019798_ChIP-Seq_JUKART_Human1.40789504
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36299036
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35945955
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35597109
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35311848
48* GATA3_26560356_Chip-Seq_TH2_Human1.35063861
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33780029
50PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33622367
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32013287
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29347898
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24922452
54TFEB_21752829_ChIP-Seq_HELA_Human1.23016794
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22178486
56* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22064648
57* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21739253
58UTX_26944678_Chip-Seq_JUKART_Human1.21120546
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16628664
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14314941
61MYB_26560356_Chip-Seq_TH1_Human1.14298065
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.13910685
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13303090
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13303090
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.12890755
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10469204
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.10453018
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06912834
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04722941
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04509656
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04272209
72MAF_26560356_Chip-Seq_TH2_Human1.04118860
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02990819
74SOX2_20726797_ChIP-Seq_SW620_Human1.02546251
75SPI1_23127762_ChIP-Seq_K562_Human1.01035717
76ELK1_19687146_ChIP-ChIP_HELA_Human1.00871793
77STAT1_20625510_ChIP-Seq_HELA_Human1.00371785
78GATA3_27048872_Chip-Seq_THYMUS_Human0.99845365
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.99096498
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97690841
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96748574
82TCF7_22412390_ChIP-Seq_EML_Mouse0.92240308
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91788417
84VDR_24763502_ChIP-Seq_THP-1_Human0.90685012
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90681520
86* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90234362
87KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89697846
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88994483
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88960340
90GATA1_19941826_ChIP-Seq_K562_Human0.87041068
91GABP_17652178_ChIP-ChIP_JURKAT_Human0.85764593
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84897132
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83669126
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83173316
95* EZH2_27294783_Chip-Seq_NPCs_Mouse0.82569588
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81866012
97* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81499549
98MAF_26560356_Chip-Seq_TH1_Human0.81302349
99* FLI1_27457419_Chip-Seq_LIVER_Mouse0.81132737
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80649367
101* NFE2_27457419_Chip-Seq_LIVER_Mouse0.80360235
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80103315
103* CJUN_26792858_Chip-Seq_BT549_Human0.79175821
104LXR_22292898_ChIP-Seq_THP-1_Human0.79031631
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78789641
106* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78486629
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78437776
108BCL6_27268052_Chip-Seq_Bcells_Human0.78100620
109* PU1_27457419_Chip-Seq_LIVER_Mouse0.77297061
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76589450
111TRIM28_21343339_ChIP-Seq_HEK293_Human0.76032364
112SRF_21415370_ChIP-Seq_HL-1_Mouse0.75822243
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75641380
114* STAT3_18555785_Chip-Seq_ESCs_Mouse0.75534950
115* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74868080
116MYC_22102868_ChIP-Seq_BL_Human0.74711534
117EGR1_19374776_ChIP-ChIP_THP-1_Human0.72447710
118KDM2B_26808549_Chip-Seq_DND41_Human0.72419320
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71358017
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71358017
121EGR1_19032775_ChIP-ChIP_M12_Human0.70363917
122* NMYC_18555785_Chip-Seq_ESCs_Mouse0.70073212
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.69790015
124SALL4_22934838_ChIP-ChIP_CD34+_Human0.69619602
125PPARA_22158963_ChIP-Seq_LIVER_Mouse0.69069798
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68865254
127* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.68045102
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67703872
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.67313576
130SPI1_20517297_ChIP-Seq_HL60_Human0.67040974
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66942384
132* P53_22387025_ChIP-Seq_ESCs_Mouse0.66659811
133* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.66415216
134GATA2_19941826_ChIP-Seq_K562_Human0.66380578
135RXR_22158963_ChIP-Seq_LIVER_Mouse0.65791270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.96710270
2MP0002148_abnormal_hypersensitivity_rea4.22867778
3MP0009785_altered_susceptibility_to4.05690871
4MP0003436_decreased_susceptibility_to3.66925243
5MP0003724_increased_susceptibility_to3.60201976
6MP0005671_abnormal_response_to3.37236541
7MP0005000_abnormal_immune_tolerance3.09448903
8MP0000685_abnormal_immune_system3.09227517
9* MP0002419_abnormal_innate_immunity3.09183008
10MP0001790_abnormal_immune_system3.00166780
11MP0005387_immune_system_phenotype3.00166780
12* MP0005025_abnormal_response_to2.93330585
13MP0006082_CNS_inflammation2.70200444
14* MP0002452_abnormal_antigen_presenting2.58973323
15* MP0002723_abnormal_immune_serum2.50185924
16MP0001800_abnormal_humoral_immune2.44503686
17MP0005058_abnormal_lysosome_morphology2.32450147
18MP0003300_gastrointestinal_ulcer2.26065342
19* MP0001819_abnormal_immune_cell2.19680409
20* MP0002420_abnormal_adaptive_immunity2.15159609
21MP0003806_abnormal_nucleotide_metabolis2.09007037
22MP0001533_abnormal_skeleton_physiology2.08941694
23MP0001853_heart_inflammation2.05901883
24MP0009764_decreased_sensitivity_to2.03763401
25MP0002006_tumorigenesis1.82397958
26MP0005464_abnormal_platelet_physiology1.81284341
27* MP0001845_abnormal_inflammatory_respons1.80476490
28MP0005310_abnormal_salivary_gland1.77040886
29MP0002405_respiratory_system_inflammati1.75691172
30MP0000604_amyloidosis1.73810931
31MP0008004_abnormal_stomach_pH1.70393720
32MP0004947_skin_inflammation1.64202689
33MP0008469_abnormal_protein_level1.64174200
34MP0010155_abnormal_intestine_physiology1.60764506
35MP0004510_myositis1.58136525
36MP0003303_peritoneal_inflammation1.54759168
37* MP0000716_abnormal_immune_system1.54363976
38MP0002277_abnormal_respiratory_mucosa1.52516372
39MP0002998_abnormal_bone_remodeling1.49101405
40MP0005451_abnormal_body_composition1.44654380
41MP0003690_abnormal_glial_cell1.41791729
42MP0003186_abnormal_redox_activity1.40267596
43MP0002166_altered_tumor_susceptibility1.39131858
44MP0009333_abnormal_splenocyte_physiolog1.37649917
45MP0002139_abnormal_hepatobiliary_system1.37147763
46* MP0002398_abnormal_bone_marrow1.37003040
47MP0003448_altered_tumor_morphology1.35341249
48MP0004782_abnormal_surfactant_physiolog1.33985269
49MP0000343_altered_response_to1.31040528
50MP0002254_reproductive_system_inflammat1.30164067
51MP0003191_abnormal_cellular_cholesterol1.29018382
52MP0001879_abnormal_lymphatic_vessel1.28157699
53MP0010386_abnormal_urinary_bladder1.23617420
54* MP0002429_abnormal_blood_cell1.22793522
55MP0005171_absent_coat_pigmentation1.20451768
56MP0001545_abnormal_hematopoietic_system1.18836696
57MP0005397_hematopoietic_system_phenotyp1.18836696
58MP0003075_altered_response_to1.17608462
59MP0002163_abnormal_gland_morphology1.17200462
60MP0005390_skeleton_phenotype1.16280914
61MP0002138_abnormal_hepatobiliary_system1.15324083
62MP0004883_abnormal_blood_vessel1.13598181
63MP0000858_altered_metastatic_potential1.13294936
64MP0000689_abnormal_spleen_morphology1.11765721
65MP0000465_gastrointestinal_hemorrhage1.08164294
66MP0000569_abnormal_digit_pigmentation1.07851418
67MP0002722_abnormal_immune_system1.07808817
68MP0010368_abnormal_lymphatic_system0.98922049
69MP0005164_abnormal_response_to0.97557148
70MP0002933_joint_inflammation0.97107202
71MP0000920_abnormal_myelination0.96610274
72MP0008260_abnormal_autophagy0.95459039
73MP0002332_abnormal_exercise_endurance0.94411523
74MP0002638_abnormal_pupillary_reflex0.92656024
75MP0001851_eye_inflammation0.92475829
76MP0006054_spinal_hemorrhage0.91922337
77MP0005379_endocrine/exocrine_gland_phen0.91753623
78MP0009697_abnormal_copulation0.90503938
79MP0003172_abnormal_lysosome_physiology0.89840515
80MP0003656_abnormal_erythrocyte_physiolo0.89266715
81MP0000015_abnormal_ear_pigmentation0.87410407
82MP0005174_abnormal_tail_pigmentation0.87072606
83MP0000681_abnormal_thyroid_gland0.87059368
84MP0005166_decreased_susceptibility_to0.85682898
85MP0001663_abnormal_digestive_system0.84997085
86MP0001542_abnormal_bone_strength0.84716655
87MP0001346_abnormal_lacrimal_gland0.84121065
88MP0003828_pulmonary_edema0.82320471
89MP0003795_abnormal_bone_structure0.81351732
90MP0005165_increased_susceptibility_to0.80897374
91MP0003453_abnormal_keratinocyte_physiol0.80249772
92MP0009763_increased_sensitivity_to0.79598734
93MP0000371_diluted_coat_color0.77907041
94MP0003763_abnormal_thymus_physiology0.77128201
95MP0002693_abnormal_pancreas_physiology0.74428115
96MP0003866_abnormal_defecation0.72812455
97MP0009840_abnormal_foam_cell0.71758301
98MP0001881_abnormal_mammary_gland0.71231706
99MP0005408_hypopigmentation0.70782762
100MP0003136_yellow_coat_color0.69425510
101MP0003195_calcinosis0.69139289
102MP0004381_abnormal_hair_follicle0.68061479
103MP0002396_abnormal_hematopoietic_system0.67909123
104MP0003183_abnormal_peptide_metabolism0.67548181
105MP0002877_abnormal_melanocyte_morpholog0.67162061
106MP0002132_abnormal_respiratory_system0.66868966
107MP0003279_aneurysm0.66388089
108MP0001873_stomach_inflammation0.66294000
109MP0000372_irregular_coat_pigmentation0.65540050
110MP0000249_abnormal_blood_vessel0.65149199
111MP0003091_abnormal_cell_migration0.65007500
112MP0009278_abnormal_bone_marrow0.64947940
113MP0005167_abnormal_blood-brain_barrier0.63388940
114MP0003941_abnormal_skin_development0.62457335
115MP0009765_abnormal_xenobiotic_induced0.61268550
116MP0000490_abnormal_crypts_of0.61222699
117MP0003566_abnormal_cell_adhesion0.61191208
118MP0003329_amyloid_beta_deposits0.60791368
119MP0002136_abnormal_kidney_physiology0.60112950
120MP0008874_decreased_physiological_sensi0.58345244
121MP0002095_abnormal_skin_pigmentation0.58052840
122MP0005319_abnormal_enzyme/_coenzyme0.57191597
123MP0005023_abnormal_wound_healing0.52914619
124MP0005584_abnormal_enzyme/coenzyme_acti0.52863246
125MP0000609_abnormal_liver_physiology0.51994978
126MP0000703_abnormal_thymus_morphology0.51245240

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.27457860
2Eczematoid dermatitis (HP:0000976)5.90639789
3Recurrent bacterial skin infections (HP:0005406)5.89756316
4Recurrent gram-negative bacterial infections (HP:0005420)4.69328482
5Abnormality of macrophages (HP:0004311)4.41378746
6Mediastinal lymphadenopathy (HP:0100721)4.10833914
7Elevated erythrocyte sedimentation rate (HP:0003565)4.01628674
8Myositis (HP:0100614)3.99673244
9Loss of speech (HP:0002371)3.96351487
10Prostate neoplasm (HP:0100787)3.87052991
11Vacuolated lymphocytes (HP:0001922)3.86562726
12Basal ganglia calcification (HP:0002135)3.82231461
13Increased IgM level (HP:0003496)3.81307796
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.80450056
15Systemic lupus erythematosus (HP:0002725)3.67850213
16Autoimmune thrombocytopenia (HP:0001973)3.67201426
17Parakeratosis (HP:0001036)3.65967164
18Recurrent skin infections (HP:0001581)3.63447817
19Optic neuritis (HP:0100653)3.62741688
20Retrobulbar optic neuritis (HP:0100654)3.62741688
21Orchitis (HP:0100796)3.59723394
22Vasculitis (HP:0002633)3.50944437
23Chronic otitis media (HP:0000389)3.39509566
24Recurrent fungal infections (HP:0002841)3.30175498
25Increased cerebral lipofuscin (HP:0011813)3.30034866
26Chronic obstructive pulmonary disease (HP:0006510)3.20645336
27Obstructive lung disease (HP:0006536)3.20645336
28Mutism (HP:0002300)3.09067654
29Gingivitis (HP:0000230)3.07722049
30Abnormality of polysaccharide metabolism (HP:0011012)3.07334658
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07334658
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07334658
33Spontaneous hematomas (HP:0007420)3.00876801
34Poor head control (HP:0002421)2.98274648
35Pustule (HP:0200039)2.95472922
36Amyloidosis (HP:0011034)2.94331101
37Petechiae (HP:0000967)2.92605341
38Axonal loss (HP:0003447)2.91352834
39Stomatitis (HP:0010280)2.91040505
40Recurrent pneumonia (HP:0006532)2.90336197
41Urinary glycosaminoglycan excretion (HP:0003541)2.90176733
42Mucopolysacchariduria (HP:0008155)2.90176733
43Periodontitis (HP:0000704)2.86812507
44Cheilitis (HP:0100825)2.86297277
45Interstitial pulmonary disease (HP:0006530)2.82805531
46Hypergammaglobulinemia (HP:0010702)2.74412865
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73612006
48Recurrent viral infections (HP:0004429)2.66908429
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.66351177
50Neurofibrillary tangles (HP:0002185)2.64357262
51Cellulitis (HP:0100658)2.61353593
52Urticaria (HP:0001025)2.60426415
53Pulmonary infiltrates (HP:0002113)2.58588786
54Abnormality of the prostate (HP:0008775)2.57325260
55Vertebral compression fractures (HP:0002953)2.56746305
56Tetraparesis (HP:0002273)2.55232901
57T lymphocytopenia (HP:0005403)2.53299685
58Gastrointestinal infarctions (HP:0005244)2.51652883
59Meningitis (HP:0001287)2.50680751
60Myocardial infarction (HP:0001658)2.49923438
61Nuclear cataract (HP:0100018)2.47362556
62Abnormality of T cell number (HP:0011839)2.47084003
63Increased serum ferritin (HP:0003281)2.45087677
64Encephalitis (HP:0002383)2.44972430
65Recurrent lower respiratory tract infections (HP:0002783)2.44134076
66Thick nail (HP:0001805)2.42576328
67Progressive neurologic deterioration (HP:0002344)2.35958446
68Hematochezia (HP:0002573)2.35925373
69Alopecia of scalp (HP:0002293)2.34882832
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34237914
71Recurrent cutaneous fungal infections (HP:0011370)2.33090249
72Chronic mucocutaneous candidiasis (HP:0002728)2.33090249
73Progressive visual loss (HP:0000529)2.31020748
74Polyneuropathy (HP:0001271)2.27938923
75Abnormality of glycolipid metabolism (HP:0010969)2.27720531
76Abnormality of liposaccharide metabolism (HP:0010968)2.27720531
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.27720531
78Eosinophilia (HP:0001880)2.27113787
79Purpura (HP:0000979)2.26031926
80Pulmonary embolism (HP:0002204)2.22847276
81Upper motor neuron abnormality (HP:0002127)2.21602676
82Hemoptysis (HP:0002105)2.21157510
83Inappropriate behavior (HP:0000719)2.17757906
84Thrombocytosis (HP:0001894)2.15640122
85Abnormality of the pleura (HP:0002103)2.12370354
86Abnormality of the pericardium (HP:0001697)2.10261232
87Osteomyelitis (HP:0002754)2.08910286
88Arterial thrombosis (HP:0004420)2.08744359
89Chest pain (HP:0100749)2.08479431
90Gingival bleeding (HP:0000225)2.08280213
91Abnormality of iron homeostasis (HP:0011031)2.08029804
92Joint swelling (HP:0001386)2.07351348
93Disinhibition (HP:0000734)2.06957240
94Episodic fever (HP:0001954)2.06294667
95Glomerulopathy (HP:0100820)2.06096868
96Apathy (HP:0000741)2.05873721
97Gastrointestinal stroma tumor (HP:0100723)2.05802204
98Keratoconjunctivitis sicca (HP:0001097)2.05671599
99Abnormal delayed hypersensitivity skin test (HP:0002963)2.05202318
100Diminished motivation (HP:0000745)2.04896271
101Leukocytosis (HP:0001974)2.04448957
102Glomerulonephritis (HP:0000099)2.03368631
103Gangrene (HP:0100758)2.03350403
104Abnormality of T cell physiology (HP:0011840)2.02899218
105Complement deficiency (HP:0004431)2.02217460
106Dysostosis multiplex (HP:0000943)2.02104389
107Restrictive lung disease (HP:0002091)2.01656002
108Premature loss of primary teeth (HP:0006323)2.01410905
109Anorexia (HP:0002039)2.01101866
110Autoimmune hemolytic anemia (HP:0001890)2.01004029
111Prolonged neonatal jaundice (HP:0006579)2.00902370
112Epistaxis (HP:0000421)2.00597527
113IgG deficiency (HP:0004315)2.00483505
114Neuronal loss in central nervous system (HP:0002529)1.99515673
115Bone pain (HP:0002653)1.98499984
116Agnosia (HP:0010524)1.97399849
117Reduced antithrombin III activity (HP:0001976)1.97002433
118Hepatosplenomegaly (HP:0001433)1.96552433
119Erythema (HP:0010783)1.94850068
120Hyperphosphatemia (HP:0002905)1.94792476
121Skin ulcer (HP:0200042)1.94697042
122Arthralgia (HP:0002829)1.93831069
123Increased IgE level (HP:0003212)1.93179908
124Abnormality of complement system (HP:0005339)1.91236882
125Pathologic fracture (HP:0002756)1.90224825
126IgM deficiency (HP:0002850)1.88056911
127Erythroderma (HP:0001019)1.87949321
128Abnormality of dental color (HP:0011073)1.87169926
129Conjunctival telangiectasia (HP:0000524)1.86852454
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.86381245
131Memory impairment (HP:0002354)1.86372262
132Vertigo (HP:0002321)1.86291311
133Keratoconjunctivitis (HP:0001096)1.85695314
134Peritonitis (HP:0002586)1.85670778
135Cerebral inclusion bodies (HP:0100314)1.85340583
136Abnormality of eosinophils (HP:0001879)1.84837140
137Granulocytopenia (HP:0001913)1.84426267
138Patchy hypopigmentation of hair (HP:0011365)1.82797635
139IgA deficiency (HP:0002720)1.82562233
140Osteolytic defects of the hand bones (HP:0009699)1.80616430
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.80616430
142Joint hemorrhage (HP:0005261)1.80240160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.09508960
2RIPK43.77760583
3PBK3.42216480
4BLK3.09943437
5IRAK32.86750296
6SIK32.75388714
7TBK12.73490963
8TYK22.59271623
9JAK32.55180921
10PIM22.47034961
11IRAK42.40187562
12BMPR1B2.39216276
13MAP2K32.29204448
14IKBKB2.27508361
15TXK2.24296497
16NME22.09911524
17MAP3K32.06585086
18IKBKE2.05688979
19ACVR1B1.99917408
20FGR1.95669883
21KIT1.81085727
22TAOK21.80943446
23MAP4K11.80866915
24TEC1.78061094
25MST41.71410261
26FES1.70821302
27BMPR21.69969261
28ADRBK21.61057899
29MAP3K111.57765560
30JAK11.55835022
31ERN11.51579539
32PRPF4B1.50621070
33DDR21.41535819
34TAOK11.39349133
35MARK31.36966849
36KDR1.32581269
37SYK1.27158253
38NEK91.23084948
39CHUK1.22736465
40EIF2AK11.22065410
41EIF2AK21.21821475
42BTK1.18842428
43EIF2AK31.17957880
44CAMKK21.16550958
45TGFBR11.15217937
46RPS6KA41.14300066
47CSF1R1.14149562
48ARAF1.13727726
49MAP3K121.13013301
50EPHA31.11982526
51YES11.09023130
52ERBB31.08245048
53TRPM71.06934706
54MST1R1.06396964
55MAP3K11.06081507
56MAP3K131.06058974
57* LYN1.04666720
58TAOK31.04530848
59PIM11.00148023
60ZAP700.98852961
61CSK0.98188013
62TGFBR20.97369189
63GRK60.96067095
64NLK0.89644262
65CDC42BPA0.85955102
66LCK0.85322205
67FLT30.85015848
68HCK0.84962389
69RIPK10.80885622
70ZAK0.80781525
71INSRR0.80655566
72STK240.80576718
73ABL20.77706413
74NUAK10.76601928
75EPHB10.71520578
76MAP3K20.70286986
77TNK20.70107242
78SIK10.69824908
79MATK0.69371074
80STK30.68489797
81PRKCD0.68206330
82CDK190.67747582
83STK100.67243036
84IRAK10.66960374
85MAP2K60.66075181
86JAK20.64841262
87MUSK0.64616148
88GRK70.63821212
89TESK20.61191134
90PDK10.60772452
91STK40.60686622
92ABL10.60576997
93EPHA20.55491034
94VRK10.54887071
95PDPK10.54311939
96BCR0.53519911
97KSR20.52115264
98SIK20.51755656
99MAPK70.50204547
100PAK40.49606067
101NEK60.47713585
102TIE10.45711616
103FYN0.44910744
104ITK0.43335030
105MAP3K60.43333755
106CDK60.41871044
107DYRK30.40410700
108RPS6KL10.40343916
109RPS6KC10.40343916
110TESK10.40072621
111DAPK20.39920375
112BMX0.39748231
113FGFR40.39594315
114MAP3K50.39107233
115PDK20.39083523
116MAPKAPK20.38510647
117IGF1R0.37458636
118RPS6KA50.35781703
119FGFR30.35437727
120EGFR0.35357715
121PRKCE0.34084703
122CLK10.32794923
123MET0.32230446
124FRK0.31744949
125PIK3CG0.31289537
126CDK80.30695498
127BRAF0.30527535
128STK38L0.30465841
129MAPK40.30038067
130MAPK120.29764638
131MYLK0.28772452
132TNIK0.28679210
133PRKCQ0.26912830
134IRAK20.26008192
135DAPK30.25927528
136PRKG20.25497446
137INSR0.25226968
138MOS0.25024617
139LRRK20.24460455
140PTK2B0.24151668
141RPS6KA60.23899090
142ERBB40.23133736

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.49235011
2Graft-versus-host disease_Homo sapiens_hsa053323.46266817
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.17242379
4Leishmaniasis_Homo sapiens_hsa051402.88922079
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.70405530
6* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.67411951
7Type I diabetes mellitus_Homo sapiens_hsa049402.58182981
8Rheumatoid arthritis_Homo sapiens_hsa053232.48279638
9* NF-kappa B signaling pathway_Homo sapiens_hsa040642.46523164
10Legionellosis_Homo sapiens_hsa051342.40395990
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.32753791
12Malaria_Homo sapiens_hsa051442.31658452
13Staphylococcus aureus infection_Homo sapiens_hsa051502.27264731
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19638919
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13408596
16Measles_Homo sapiens_hsa051622.11196796
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.91513364
18Autoimmune thyroid disease_Homo sapiens_hsa053201.91177919
19Tuberculosis_Homo sapiens_hsa051521.87403743
20Asthma_Homo sapiens_hsa053101.86374420
21Osteoclast differentiation_Homo sapiens_hsa043801.86327202
22African trypanosomiasis_Homo sapiens_hsa051431.81625730
23* Pertussis_Homo sapiens_hsa051331.78873369
24TNF signaling pathway_Homo sapiens_hsa046681.75587708
25Lysosome_Homo sapiens_hsa041421.73130015
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71701330
27Herpes simplex infection_Homo sapiens_hsa051681.63091813
28Influenza A_Homo sapiens_hsa051641.61525735
29Primary immunodeficiency_Homo sapiens_hsa053401.52578800
30Phagosome_Homo sapiens_hsa041451.52559060
31Hematopoietic cell lineage_Homo sapiens_hsa046401.52401962
32Proteasome_Homo sapiens_hsa030501.49529768
33Salmonella infection_Homo sapiens_hsa051321.39708492
34Other glycan degradation_Homo sapiens_hsa005111.38790527
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.33642338
36Antigen processing and presentation_Homo sapiens_hsa046121.28743846
37Protein export_Homo sapiens_hsa030601.25416960
38Chemokine signaling pathway_Homo sapiens_hsa040621.17579755
39* Toxoplasmosis_Homo sapiens_hsa051451.16667181
40Apoptosis_Homo sapiens_hsa042101.13966109
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09261058
42Shigellosis_Homo sapiens_hsa051311.06436940
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03460205
44Sphingolipid metabolism_Homo sapiens_hsa006001.01499987
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.99272396
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98081349
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97593990
48B cell receptor signaling pathway_Homo sapiens_hsa046620.96676630
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88433393
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87104676
51Hepatitis B_Homo sapiens_hsa051610.85063016
52Hepatitis C_Homo sapiens_hsa051600.80642377
53Viral myocarditis_Homo sapiens_hsa054160.80463221
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74355693
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66344992
56Collecting duct acid secretion_Homo sapiens_hsa049660.65841379
57Regulation of autophagy_Homo sapiens_hsa041400.65102918
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.63926663
59Epstein-Barr virus infection_Homo sapiens_hsa051690.62885040
60Systemic lupus erythematosus_Homo sapiens_hsa053220.61587178
61Amoebiasis_Homo sapiens_hsa051460.58990844
62* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56845767
63Folate biosynthesis_Homo sapiens_hsa007900.56757940
64Complement and coagulation cascades_Homo sapiens_hsa046100.54561386
65Mineral absorption_Homo sapiens_hsa049780.54279182
66Arachidonic acid metabolism_Homo sapiens_hsa005900.54220267
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53759145
68Prion diseases_Homo sapiens_hsa050200.53487228
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52956733
70Bladder cancer_Homo sapiens_hsa052190.52136973
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51526861
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50447142
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48079697
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46616998
75Vitamin digestion and absorption_Homo sapiens_hsa049770.45662805
76Prolactin signaling pathway_Homo sapiens_hsa049170.44534319
77Endocytosis_Homo sapiens_hsa041440.43099241
78Acute myeloid leukemia_Homo sapiens_hsa052210.42938415
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42306730
80VEGF signaling pathway_Homo sapiens_hsa043700.41459794
81T cell receptor signaling pathway_Homo sapiens_hsa046600.40964764
82Caffeine metabolism_Homo sapiens_hsa002320.36119211
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.35974587
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35162235
85HIF-1 signaling pathway_Homo sapiens_hsa040660.33095659
86Galactose metabolism_Homo sapiens_hsa000520.32880296
87p53 signaling pathway_Homo sapiens_hsa041150.32441150
88Vibrio cholerae infection_Homo sapiens_hsa051100.32173978
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.31270246
90Pancreatic cancer_Homo sapiens_hsa052120.30284203
91RNA polymerase_Homo sapiens_hsa030200.30233789
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29679157
93Platelet activation_Homo sapiens_hsa046110.28592970
94Ribosome_Homo sapiens_hsa030100.27966494
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27751871
96Renal cell carcinoma_Homo sapiens_hsa052110.26023358
97Homologous recombination_Homo sapiens_hsa034400.25294308
98Sulfur metabolism_Homo sapiens_hsa009200.23327744
99HTLV-I infection_Homo sapiens_hsa051660.22512243
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.20671668
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19362882
102PPAR signaling pathway_Homo sapiens_hsa033200.18864124
103Histidine metabolism_Homo sapiens_hsa003400.18817116
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18641032
105Viral carcinogenesis_Homo sapiens_hsa052030.16831809
106Non-small cell lung cancer_Homo sapiens_hsa052230.16770710
107Dorso-ventral axis formation_Homo sapiens_hsa043200.16452764
108Chronic myeloid leukemia_Homo sapiens_hsa052200.16189453
109ABC transporters_Homo sapiens_hsa020100.15358009
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15205889
111FoxO signaling pathway_Homo sapiens_hsa040680.12705922
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12653058
113Pyrimidine metabolism_Homo sapiens_hsa002400.11228174
114MAPK signaling pathway_Homo sapiens_hsa040100.11201132
115GnRH signaling pathway_Homo sapiens_hsa049120.10266423
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.08398372
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07539711
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.07464319

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