LYAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.34318504
2piRNA metabolic process (GO:0034587)5.08556940
3sperm-egg recognition (GO:0035036)4.71968912
4binding of sperm to zona pellucida (GO:0007339)4.70985329
5fusion of sperm to egg plasma membrane (GO:0007342)4.64758987
6establishment of integrated proviral latency (GO:0075713)4.59318072
7proteasome assembly (GO:0043248)4.52849029
8male meiosis (GO:0007140)4.51131390
9synaptonemal complex assembly (GO:0007130)4.41738313
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.39774296
11synaptonemal complex organization (GO:0070193)4.32804426
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.21164631
13cell-cell recognition (GO:0009988)4.17446055
14nuclear pore organization (GO:0006999)4.15861740
15DNA deamination (GO:0045006)4.13850731
16nuclear pore complex assembly (GO:0051292)4.11868886
17mitotic metaphase plate congression (GO:0007080)4.10132698
18axonemal dynein complex assembly (GO:0070286)4.03242366
19sperm motility (GO:0030317)4.02933432
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02593914
21DNA replication-dependent nucleosome assembly (GO:0006335)4.01725963
22DNA replication-dependent nucleosome organization (GO:0034723)4.01725963
23DNA strand elongation involved in DNA replication (GO:0006271)3.98383889
24protein localization to chromosome, centromeric region (GO:0071459)3.98040803
25DNA replication initiation (GO:0006270)3.96267996
26pseudouridine synthesis (GO:0001522)3.88991679
27rRNA modification (GO:0000154)3.86662140
28maturation of SSU-rRNA (GO:0030490)3.83522515
29DNA replication checkpoint (GO:0000076)3.83158575
30formation of translation preinitiation complex (GO:0001731)3.82275762
31chaperone-mediated protein transport (GO:0072321)3.81789941
32acrosome assembly (GO:0001675)3.80814608
33histone exchange (GO:0043486)3.80696891
34protein localization to kinetochore (GO:0034501)3.79691966
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.78524075
36DNA strand elongation (GO:0022616)3.78089762
37spermatid development (GO:0007286)3.76992597
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.74063177
39mitotic nuclear envelope disassembly (GO:0007077)3.72085640
40motile cilium assembly (GO:0044458)3.70144614
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69966839
42negative regulation of ligase activity (GO:0051352)3.69966839
43chromatin remodeling at centromere (GO:0031055)3.69898175
44IMP biosynthetic process (GO:0006188)3.69623736
45nucleobase biosynthetic process (GO:0046112)3.68656572
46DNA unwinding involved in DNA replication (GO:0006268)3.68001240
47multicellular organism reproduction (GO:0032504)3.67868841
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64983973
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.61505618
50ATP synthesis coupled proton transport (GO:0015986)3.61505618
51establishment of viral latency (GO:0019043)3.60585039
52chromosome organization involved in meiosis (GO:0070192)3.59845647
53regulation of mitochondrial translation (GO:0070129)3.59688274
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59607705
55maturation of 5.8S rRNA (GO:0000460)3.58644240
56DNA methylation involved in gamete generation (GO:0043046)3.56515014
57meiotic nuclear division (GO:0007126)3.56088829
58telomere maintenance via semi-conservative replication (GO:0032201)3.55154295
59translation (GO:0006412)3.54103421
60purine nucleobase biosynthetic process (GO:0009113)3.53966584
61cotranslational protein targeting to membrane (GO:0006613)3.53694477
62metaphase plate congression (GO:0051310)3.53398728
63ribosome biogenesis (GO:0042254)3.53157308
64male meiosis I (GO:0007141)3.52245128
65CENP-A containing nucleosome assembly (GO:0034080)3.51826790
66protein targeting to ER (GO:0045047)3.51794061
67cellular component biogenesis (GO:0044085)3.51464055
68ribosome assembly (GO:0042255)3.51415112
69translational elongation (GO:0006414)3.47641598
70membrane disassembly (GO:0030397)3.44603592
71nuclear envelope disassembly (GO:0051081)3.44603592
72ribosomal large subunit biogenesis (GO:0042273)3.43514363
73chaperone-mediated protein complex assembly (GO:0051131)3.42763737
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.37711976
75DNA replication-independent nucleosome assembly (GO:0006336)3.37551275
76DNA replication-independent nucleosome organization (GO:0034724)3.37551275
77meiosis I (GO:0007127)3.36707168
78IMP metabolic process (GO:0046040)3.36123430
79termination of RNA polymerase III transcription (GO:0006386)3.35011929
80transcription elongation from RNA polymerase III promoter (GO:0006385)3.35011929
81rRNA methylation (GO:0031167)3.34901849
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.34503622
83mitotic sister chromatid segregation (GO:0000070)3.34159814
84ribonucleoprotein complex biogenesis (GO:0022613)3.33087450
85telomere maintenance via recombination (GO:0000722)3.31480710
86spliceosomal snRNP assembly (GO:0000387)3.31434232
87protein targeting to mitochondrion (GO:0006626)3.31229244
88plasma membrane fusion (GO:0045026)3.31105917
89regulation of centriole replication (GO:0046599)3.29384875
90protein localization to endoplasmic reticulum (GO:0070972)3.29280606
91DNA ligation (GO:0006266)3.26773831
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24884816
93epithelial cilium movement (GO:0003351)3.20917499
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20657619
95microtubule depolymerization (GO:0007019)3.20171160
96kinetochore organization (GO:0051383)3.20168110
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19890367
98heterochromatin organization (GO:0070828)3.19773404
99transcription from mitochondrial promoter (GO:0006390)3.19082218
100pore complex assembly (GO:0046931)3.19034361
101regulation of cilium movement (GO:0003352)3.17257105
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15627757
103meiotic cell cycle (GO:0051321)3.14917599
104regulation of centrosome cycle (GO:0046605)3.14864222
105ribosomal small subunit assembly (GO:0000028)3.14768180
106rRNA processing (GO:0006364)3.14546480
107mitotic recombination (GO:0006312)3.13585412
108termination of RNA polymerase II transcription (GO:0006369)3.12856746
109negative regulation of RNA splicing (GO:0033119)3.12248917
110regulation of histone H3-K9 methylation (GO:0051570)3.12042993
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11895969
112transcription-coupled nucleotide-excision repair (GO:0006283)3.11503341
113viral life cycle (GO:0019058)3.10336149
114mitotic sister chromatid cohesion (GO:0007064)3.10153386
115positive regulation of ligase activity (GO:0051351)3.09369853
116protein complex localization (GO:0031503)3.09233534
117rRNA metabolic process (GO:0016072)3.08938838
118establishment of chromosome localization (GO:0051303)3.08077391
119mitochondrial RNA metabolic process (GO:0000959)3.06767170
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06333519
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06333519
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06333519
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06077731
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05809735
125intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05715278
126signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05715278
127cell wall macromolecule catabolic process (GO:0016998)3.05711752
128cell wall macromolecule metabolic process (GO:0044036)3.05711752
129mitotic chromosome condensation (GO:0007076)3.05449184
130establishment of protein localization to mitochondrion (GO:0072655)3.05285119
131chromosome condensation (GO:0030261)3.05015833
132histone mRNA metabolic process (GO:0008334)3.04742434
133viral mRNA export from host cell nucleus (GO:0046784)3.04532579
134cellular protein complex disassembly (GO:0043624)3.04241158
135regulation of chromosome segregation (GO:0051983)3.03818430
136regulation of cellular amino acid metabolic process (GO:0006521)3.03365154
137attachment of spindle microtubules to kinetochore (GO:0008608)3.03053529
138monoubiquitinated protein deubiquitination (GO:0035520)3.02799722
139signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02367320
140signal transduction involved in DNA damage checkpoint (GO:0072422)3.02367320
141nucleotide-excision repair, DNA gap filling (GO:0006297)3.02297141
142translational initiation (GO:0006413)3.02127776
143translational termination (GO:0006415)3.00512800
144viral transcription (GO:0019083)3.00000711
145protein K6-linked ubiquitination (GO:0085020)2.99834014
146translesion synthesis (GO:0019985)2.99407068
147DNA packaging (GO:0006323)2.98716070
148gene silencing by RNA (GO:0031047)2.98109386
149meiotic cell cycle process (GO:1903046)2.97185766
150telomere maintenance via telomere lengthening (GO:0010833)2.96660485
151folic acid-containing compound biosynthetic process (GO:0009396)2.96304366
152regulation of spindle organization (GO:0090224)2.95720841
153reproduction (GO:0000003)2.94159756
154ATP-dependent chromatin remodeling (GO:0043044)2.93918892
155histone H2A acetylation (GO:0043968)2.93891118
156ribosomal small subunit biogenesis (GO:0042274)2.93379201
157meiotic chromosome segregation (GO:0045132)2.92477704
158chromatin assembly or disassembly (GO:0006333)2.92347538
159sister chromatid segregation (GO:0000819)2.91646534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.57844408
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.46381963
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.21361096
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.88364311
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.54908349
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34255458
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16353550
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01853462
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89744679
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.86228882
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81597426
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81381025
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78501882
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.78152557
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.60183145
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57186910
17XRN2_22483619_ChIP-Seq_HELA_Human2.32101296
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17786812
19VDR_23849224_ChIP-Seq_CD4+_Human2.17229233
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14698179
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09280844
22MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07325929
23* AR_21909140_ChIP-Seq_LNCAP_Human2.03952557
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02832874
25DCP1A_22483619_ChIP-Seq_HELA_Human1.98381956
26FOXP3_21729870_ChIP-Seq_TREG_Human1.93515524
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91063400
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89221613
29* GABP_19822575_ChIP-Seq_HepG2_Human1.87327454
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.86092750
31TTF2_22483619_ChIP-Seq_HELA_Human1.79413151
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74590831
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72563520
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72159016
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72002740
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70746431
37* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66549925
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.64215658
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63368130
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60307794
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59261205
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55412998
43* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53775155
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51071268
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48416199
46KDM5A_27292631_Chip-Seq_BREAST_Human1.48352616
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44492191
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41731881
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39887662
50CIITA_25753668_ChIP-Seq_RAJI_Human1.35759251
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34950975
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34006376
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30079319
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29601853
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29034398
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28026308
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27437286
58ELK1_19687146_ChIP-ChIP_HELA_Human1.25838932
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24392566
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21824683
61MYC_22102868_ChIP-Seq_BL_Human1.20980293
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19809444
63* SRF_21415370_ChIP-Seq_HL-1_Mouse1.16906071
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16054100
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13593323
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11212175
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09449472
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07457669
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06363099
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05763686
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.05137716
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03563115
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03401391
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00775808
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99977719
76EGR1_19374776_ChIP-ChIP_THP-1_Human0.99870947
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98530355
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97316238
79MYC_18940864_ChIP-ChIP_HL60_Human0.97194117
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.96441241
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96135150
82ELK1_22589737_ChIP-Seq_MCF10A_Human0.96096137
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93969256
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93116634
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92525045
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92524401
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90047456
88TFEB_21752829_ChIP-Seq_HELA_Human0.88671306
89* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88298827
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84591855
91YY1_22570637_ChIP-Seq_MALME-3M_Human0.83572842
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83283327
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.83198860
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82641198
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82565567
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80169478
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.79686032
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79457552
99FOXP1_21924763_ChIP-Seq_HESCs_Human0.76729394
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.75621362
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75340093
102TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73994849
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72781716
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71850020
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71073860
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70964967
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.68867686
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68654867
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.67963033
110ZNF263_19887448_ChIP-Seq_K562_Human0.66953575
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.66747143
112SPI1_23547873_ChIP-Seq_NB4_Human0.65989634
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.65832354
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65009619
115* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64550412
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.64141454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.31991515
2MP0003693_abnormal_embryo_hatching5.21681020
3MP0010094_abnormal_chromosome_stability4.49238186
4MP0008877_abnormal_DNA_methylation4.36610000
5MP0003111_abnormal_nucleus_morphology4.33776228
6MP0004957_abnormal_blastocyst_morpholog4.13952201
7MP0008057_abnormal_DNA_replication4.12113290
8MP0003077_abnormal_cell_cycle3.73384877
9MP0008058_abnormal_DNA_repair3.60625508
10MP0001929_abnormal_gametogenesis2.98244094
11MP0008007_abnormal_cellular_replicative2.87210254
12MP0003698_abnormal_male_reproductive2.63814384
13MP0002210_abnormal_sex_determination2.62443734
14MP0008932_abnormal_embryonic_tissue2.44107781
15MP0001730_embryonic_growth_arrest2.41055254
16MP0009379_abnormal_foot_pigmentation2.34977693
17MP0001145_abnormal_male_reproductive2.25489261
18MP0002653_abnormal_ependyma_morphology2.21657878
19MP0009697_abnormal_copulation2.19327335
20MP0003786_premature_aging2.11602920
21MP0003123_paternal_imprinting2.08846945
22MP0000350_abnormal_cell_proliferation2.00458179
23MP0000653_abnormal_sex_gland1.94726349
24MP0001672_abnormal_embryogenesis/_devel1.75701314
25MP0005380_embryogenesis_phenotype1.75701314
26MP0001697_abnormal_embryo_size1.65852752
27MP0010307_abnormal_tumor_latency1.65646613
28MP0002160_abnormal_reproductive_system1.64302809
29MP0002396_abnormal_hematopoietic_system1.64252653
30MP0010352_gastrointestinal_tract_polyps1.61729107
31MP0002161_abnormal_fertility/fecundity1.61064278
32MP0003984_embryonic_growth_retardation1.55180055
33MP0002080_prenatal_lethality1.51895198
34MP0003718_maternal_effect1.50920994
35MP0002088_abnormal_embryonic_growth/wei1.50368898
36MP0002085_abnormal_embryonic_tissue1.46078495
37MP0000313_abnormal_cell_death1.43937405
38MP0002084_abnormal_developmental_patter1.40834443
39MP0000490_abnormal_crypts_of1.29713940
40MP0005671_abnormal_response_to1.28680972
41MP0001293_anophthalmia1.28150542
42MP0004808_abnormal_hematopoietic_stem1.22704518
43MP0004197_abnormal_fetal_growth/weight/1.22603024
44MP0002086_abnormal_extraembryonic_tissu1.22047012
45MP0002019_abnormal_tumor_incidence1.21280105
46MP0002877_abnormal_melanocyte_morpholog1.20725006
47MP0003890_abnormal_embryonic-extraembry1.15088491
48MP0001545_abnormal_hematopoietic_system1.11794420
49MP0005397_hematopoietic_system_phenotyp1.11794420
50MP0004185_abnormal_adipocyte_glucose1.08516320
51MP0005389_reproductive_system_phenotype1.06972619
52MP0000358_abnormal_cell_content/1.04522786
53MP0001853_heart_inflammation1.02993060
54MP0010030_abnormal_orbit_morphology1.00938902
55MP0003806_abnormal_nucleotide_metabolis0.99569260
56MP0003315_abnormal_perineum_morphology0.99219438
57MP0003567_abnormal_fetal_cardiomyocyte0.97725100
58MP0004147_increased_porphyrin_level0.93405024
59MP0003119_abnormal_digestive_system0.93204691
60MP0000372_irregular_coat_pigmentation0.92869600
61MP0002163_abnormal_gland_morphology0.90831267
62MP0002277_abnormal_respiratory_mucosa0.90192565
63MP0009333_abnormal_splenocyte_physiolog0.89669489
64MP0004133_heterotaxia0.89567673
65MP0009672_abnormal_birth_weight0.89407225
66MP0002796_impaired_skin_barrier0.89272798
67MP0001764_abnormal_homeostasis0.88554811
68MP0005076_abnormal_cell_differentiation0.87763130
69MP0001881_abnormal_mammary_gland0.87039278
70MP0001119_abnormal_female_reproductive0.86153612
71MP0005501_abnormal_skin_physiology0.84428887
72MP0003646_muscle_fatigue0.84356295
73MP0000703_abnormal_thymus_morphology0.84079690
74MP0006292_abnormal_olfactory_placode0.83348900
75MP0003763_abnormal_thymus_physiology0.82393247
76MP0008995_early_reproductive_senescence0.77477938
77MP0000537_abnormal_urethra_morphology0.75390548
78MP0005670_abnormal_white_adipose0.75173316
79MP0002102_abnormal_ear_morphology0.74377730
80MP0003121_genomic_imprinting0.74077709
81MP0002132_abnormal_respiratory_system0.72882919
82MP0001661_extended_life_span0.69090132
83MP0006036_abnormal_mitochondrial_physio0.67767731
84MP0005395_other_phenotype0.67629863
85MP0005451_abnormal_body_composition0.66549459
86MP0004233_abnormal_muscle_weight0.65483170
87MP0001286_abnormal_eye_development0.65074913
88MP0003699_abnormal_female_reproductive0.64413372
89MP0001529_abnormal_vocalization0.64383906
90MP0000750_abnormal_muscle_regeneration0.64180945
91MP0002722_abnormal_immune_system0.64113470
92MP0000627_abnormal_mammary_gland0.63970059
93MP0005384_cellular_phenotype0.63870946
94MP0002398_abnormal_bone_marrow0.63795885
95MP0009703_decreased_birth_body0.63609757
96MP0009278_abnormal_bone_marrow0.63059524
97MP0006072_abnormal_retinal_apoptosis0.61937613
98MP0000678_abnormal_parathyroid_gland0.61542893
99MP0000716_abnormal_immune_system0.61341211
100MP0002938_white_spotting0.61092347
101MP0002092_abnormal_eye_morphology0.60774964
102MP0006035_abnormal_mitochondrial_morpho0.60729616
103MP0001873_stomach_inflammation0.60250016
104MP0001727_abnormal_embryo_implantation0.60006616
105MP0000689_abnormal_spleen_morphology0.59382820
106MP0003950_abnormal_plasma_membrane0.58748743
107MP0003221_abnormal_cardiomyocyte_apopto0.58344842
108MP0000858_altered_metastatic_potential0.57202724
109MP0002697_abnormal_eye_size0.56343757
110MP0008789_abnormal_olfactory_epithelium0.56234794
111MP0005408_hypopigmentation0.55995944
112MP0001835_abnormal_antigen_presentation0.55606472
113MP0005621_abnormal_cell_physiology0.55196708
114MP0001915_intracranial_hemorrhage0.54356695
115MP0001919_abnormal_reproductive_system0.53951503
116MP0002282_abnormal_trachea_morphology0.53872975
117MP0005377_hearing/vestibular/ear_phenot0.53748049
118MP0003878_abnormal_ear_physiology0.53748049
119MP0003186_abnormal_redox_activity0.53606927
120MP0001849_ear_inflammation0.53181958
121MP0003011_delayed_dark_adaptation0.52784762
122MP0003941_abnormal_skin_development0.51880055
123MP0009053_abnormal_anal_canal0.51557783
124MP0000432_abnormal_head_morphology0.50811145
125MP0005391_vision/eye_phenotype0.50599675
126MP0003937_abnormal_limbs/digits/tail_de0.50496239
127MP0002111_abnormal_tail_morphology0.49686951
128MP0005623_abnormal_meninges_morphology0.49027611
129MP0002429_abnormal_blood_cell0.47964885

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.11022716
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.90674704
3Absent/shortened dynein arms (HP:0200106)5.90674704
4Abnormal respiratory epithelium morphology (HP:0012253)4.65227108
5Abnormal respiratory motile cilium morphology (HP:0005938)4.65227108
6Chronic bronchitis (HP:0004469)4.61032383
7Abnormal respiratory motile cilium physiology (HP:0012261)4.59354904
8Increased hepatocellular lipid droplets (HP:0006565)4.28833940
9Acute necrotizing encephalopathy (HP:0006965)4.19341397
10Rhinitis (HP:0012384)4.17946734
11Abnormality of the anterior horn cell (HP:0006802)4.04465439
12Degeneration of anterior horn cells (HP:0002398)4.04465439
13Birth length less than 3rd percentile (HP:0003561)4.01873804
14Abnormal mitochondria in muscle tissue (HP:0008316)3.88257931
15Lipid accumulation in hepatocytes (HP:0006561)3.78753804
16Impulsivity (HP:0100710)3.68732584
17Acute encephalopathy (HP:0006846)3.67871951
18Selective tooth agenesis (HP:0001592)3.60629169
19Mitochondrial inheritance (HP:0001427)3.57912274
20Increased CSF lactate (HP:0002490)3.52716741
21Abnormality of cells of the erythroid lineage (HP:0012130)3.48146350
22Abnormal ciliary motility (HP:0012262)3.46526065
23Reticulocytopenia (HP:0001896)3.42504708
24Nasal polyposis (HP:0100582)3.39327375
25Breast hypoplasia (HP:0003187)3.34708862
26Abnormal number of erythroid precursors (HP:0012131)3.29096034
27Progressive macrocephaly (HP:0004481)3.22793255
28Abnormal spermatogenesis (HP:0008669)3.16915224
29Infertility (HP:0000789)3.15143485
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.13910800
31Increased intramyocellular lipid droplets (HP:0012240)3.09331413
32Oral leukoplakia (HP:0002745)3.09168711
33Aplasia/Hypoplasia of the sacrum (HP:0008517)3.08500485
34Supernumerary spleens (HP:0009799)3.05548084
35Renal Fanconi syndrome (HP:0001994)3.05182991
36Chromsome breakage (HP:0040012)3.03912504
37Increased serum lactate (HP:0002151)3.01338243
38Microvesicular hepatic steatosis (HP:0001414)2.97659991
39Carpal bone hypoplasia (HP:0001498)2.90054973
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89933754
4111 pairs of ribs (HP:0000878)2.89663469
42Bronchitis (HP:0012387)2.89286082
43Abnormality of the preputium (HP:0100587)2.88669482
44Cerebral edema (HP:0002181)2.87932658
45Hepatocellular necrosis (HP:0001404)2.86498127
46Meckel diverticulum (HP:0002245)2.83970201
47Respiratory difficulties (HP:0002880)2.80494778
48Progressive muscle weakness (HP:0003323)2.76978595
49Absent thumb (HP:0009777)2.73566967
50Bronchiectasis (HP:0002110)2.72546598
51Nephronophthisis (HP:0000090)2.71890839
52Abnormality of the ileum (HP:0001549)2.69955047
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69656796
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69656796
55Abnormality of chromosome stability (HP:0003220)2.69159679
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65976683
57Abnormality of alanine metabolism (HP:0010916)2.65976683
58Hyperalaninemia (HP:0003348)2.65976683
59Abnormality of the nasal mucosa (HP:0000433)2.65693742
60Increased serum pyruvate (HP:0003542)2.61379520
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.59025647
62Patellar aplasia (HP:0006443)2.58605203
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.58399949
64Rough bone trabeculation (HP:0100670)2.55728773
65Hepatic necrosis (HP:0002605)2.55393363
66Lactic acidosis (HP:0003128)2.53828016
67Exertional dyspnea (HP:0002875)2.50198674
68Exercise intolerance (HP:0003546)2.48992655
69Increased muscle lipid content (HP:0009058)2.48066288
70Aplasia/Hypoplasia of the patella (HP:0006498)2.46440844
71Sloping forehead (HP:0000340)2.45687638
72Abnormality of the lower motor neuron (HP:0002366)2.44519810
73Facial cleft (HP:0002006)2.43732189
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42187710
75Medulloblastoma (HP:0002885)2.41452136
76Colon cancer (HP:0003003)2.38363477
77Ectopic kidney (HP:0000086)2.38124639
78Gonadotropin excess (HP:0000837)2.36748505
79Ependymoma (HP:0002888)2.35562312
80Abnormality of glycolysis (HP:0004366)2.35452831
81Atrophy/Degeneration involving motor neurons (HP:0007373)2.34445929
82Cerebral hypomyelination (HP:0006808)2.33295254
83Macrocytic anemia (HP:0001972)2.32429793
84IgM deficiency (HP:0002850)2.31474136
85Leukodystrophy (HP:0002415)2.31008379
86Type I transferrin isoform profile (HP:0003642)2.30937915
87Reduced antithrombin III activity (HP:0001976)2.30653566
88Male infertility (HP:0003251)2.30465136
893-Methylglutaconic aciduria (HP:0003535)2.29575879
90Aplastic anemia (HP:0001915)2.27239332
91Duodenal stenosis (HP:0100867)2.25433871
92Small intestinal stenosis (HP:0012848)2.25433871
93Abnormality of methionine metabolism (HP:0010901)2.24403817
94Abnormality of the pons (HP:0007361)2.21788757
95Sparse eyelashes (HP:0000653)2.21452703
96Trismus (HP:0000211)2.21352425
97Pallor (HP:0000980)2.20940636
98Hypoplasia of the pons (HP:0012110)2.19896338
99Hypoplasia of the radius (HP:0002984)2.18827884
100Absent radius (HP:0003974)2.18587971
101Myelodysplasia (HP:0002863)2.17547459
102Cleft eyelid (HP:0000625)2.16609770
103Amyotrophic lateral sclerosis (HP:0007354)2.16012056
104Neoplasm of the pancreas (HP:0002894)2.12755913
105Azoospermia (HP:0000027)2.09550049
106Premature ovarian failure (HP:0008209)2.08855442
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08752837
108Progressive external ophthalmoplegia (HP:0000590)2.08485380
109Squamous cell carcinoma (HP:0002860)2.07710161
110Homocystinuria (HP:0002156)2.04748610
111Abnormality of homocysteine metabolism (HP:0010919)2.04748610
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04493715
113Absent epiphyses (HP:0010577)2.04493715
114Bone marrow hypocellularity (HP:0005528)2.03489928
115Horseshoe kidney (HP:0000085)2.03221720
116Abnormal lung lobation (HP:0002101)2.03039178
117Megaloblastic anemia (HP:0001889)2.02879081
118Missing ribs (HP:0000921)2.02472149
119Abnormality of abdominal situs (HP:0011620)2.02290477
120Abdominal situs inversus (HP:0003363)2.02290477
121Respiratory failure (HP:0002878)2.01654791
122Aplasia involving forearm bones (HP:0009822)2.00921595
123Absent forearm bone (HP:0003953)2.00921595
124Abnormality of serum amino acid levels (HP:0003112)1.99064857
125Abnormal trabecular bone morphology (HP:0100671)1.97698091
126Multiple enchondromatosis (HP:0005701)1.95275612
127Rhabdomyosarcoma (HP:0002859)1.94087647
128Recurrent otitis media (HP:0000403)1.93895490
129Prominent nose (HP:0000448)1.93255084
130Secondary amenorrhea (HP:0000869)1.93158785
131Amniotic constriction ring (HP:0009775)1.92812281
132Abnormality of placental membranes (HP:0011409)1.92812281
133Abnormal number of incisors (HP:0011064)1.92631037
134Tracheoesophageal fistula (HP:0002575)1.90924459
135Atresia of the external auditory canal (HP:0000413)1.89754421
136Microretrognathia (HP:0000308)1.88951514
137Triphalangeal thumb (HP:0001199)1.88852963
138Premature graying of hair (HP:0002216)1.87290984
139Abnormality of the renal medulla (HP:0100957)1.87280621
140Combined immunodeficiency (HP:0005387)1.87230690
141Pancytopenia (HP:0001876)1.86444670
142Recurrent sinusitis (HP:0011108)1.85027304
143Abnormality of the carotid arteries (HP:0005344)1.83954457
144Agnosia (HP:0010524)1.83625322
145Nephroblastoma (Wilms tumor) (HP:0002667)1.82600249
146Embryonal renal neoplasm (HP:0011794)1.82515077
147Pendular nystagmus (HP:0012043)1.80954627
148Abnormal umbilical cord blood vessels (HP:0011403)1.80747768
149Single umbilical artery (HP:0001195)1.80747768
150Abnormality of the fetal cardiovascular system (HP:0010948)1.80747768
151Abnormality of the duodenum (HP:0002246)1.80449702
152Short ribs (HP:0000773)1.79823816
153Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79621258
154Abnormal protein N-linked glycosylation (HP:0012347)1.79621258
155Abnormal protein glycosylation (HP:0012346)1.79621258
156Abnormal glycosylation (HP:0012345)1.79621258
157Aplasia/hypoplasia of the humerus (HP:0006507)1.78430623
158Cellular immunodeficiency (HP:0005374)1.78172194
159High pitched voice (HP:0001620)1.76688432
160Abnormality of renal resorption (HP:0011038)1.75548216
161Recurrent bronchitis (HP:0002837)1.74788548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.50565464
2PDK34.50565464
3CDC74.08090505
4WEE13.99630890
5BUB13.96585215
6VRK23.76180615
7NEK23.36257514
8EIF2AK13.30531185
9PDK22.86579755
10MST42.71675889
11TTK2.51459091
12TESK12.42862128
13PLK42.17725287
14PNCK2.15822381
15SRPK12.13992058
16PLK11.89918372
17DYRK31.87805384
18BRSK21.73726928
19ACVR1B1.70332218
20PASK1.69053101
21TESK21.68663803
22NME21.67990729
23TAF11.66151662
24CDK121.65308922
25ATR1.63909370
26STK161.57261470
27NEK11.53591122
28RPS6KA41.51138723
29CDK71.50974159
30TSSK61.50845172
31EIF2AK31.48722225
32CHEK21.47653418
33AURKB1.45207897
34MKNK11.43045880
35TLK11.41247069
36MKNK21.37469632
37NUAK11.34999795
38CHEK11.34697833
39ICK1.23696268
40CCNB11.22371824
41TRIM281.16991823
42PLK31.16419928
43AURKA1.14270022
44CDK41.14209263
45VRK11.11560695
46PRKD31.07914940
47STK101.03712628
48RPS6KB21.03517593
49MAP3K81.03042964
50BRSK11.02099441
51STK38L0.96592610
52ATM0.92967027
53SMG10.91557431
54STK30.88242608
55EPHA20.87692202
56EEF2K0.82170792
57CDK20.80287210
58CLK10.79104282
59PAK40.77676152
60PAK10.72772255
61SCYL20.72381818
62PBK0.71141440
63MAP3K100.69738572
64STK40.69259211
65CSNK2A20.68300210
66CSNK2A10.64855606
67KDR0.64221949
68BRAF0.62443732
69PIM10.57369051
70CDK10.56723433
71TAOK20.55450413
72ILK0.54947991
73MAP3K120.53255077
74ZAK0.53208443
75DAPK10.51064758
76MTOR0.50330482
77TGFBR10.50131995
78ERBB40.49471105
79TXK0.47540863
80IRAK30.46303078
81ALK0.46194072
82LATS20.44933739
83BRD40.44809699
84MAP2K30.43501705
85EIF2AK20.43290194
86TNIK0.42901017
87CSNK1E0.42145413
88PTK2B0.40425442
89RPS6KA50.40284829
90MELK0.40008065
91ARAF0.39926181
92PIM20.39673504
93MAP3K110.39630563
94INSRR0.39022679
95CDK60.38719687
96PRKCI0.38069772
97TEC0.34852438
98NME10.31856420
99MAP4K10.31705054
100PRKDC0.31482592
101LIMK10.31146869
102CDK90.30499604
103CDK80.29011593
104PAK20.28370575
105ZAP700.23627595
106STK380.22444447
107MAPKAPK30.22418441
108RAF10.22241413
109AKT20.22231327
110MAP2K60.21656565
111MARK30.20820844
112ABL20.20226879
113WNK40.18623255
114LRRK20.18403407
115BMPR1B0.18371648
116RPS6KA10.18149397
117RPS6KB10.17482287
118MAP2K70.17150292
119DYRK20.16690220
120MAPK140.16613508
121DYRK1B0.15439332
122CSNK1D0.14871163
123BCKDK0.14343953
124FGFR10.14251146
125GSK3B0.13829897
126MST1R0.13314336
127STK240.13165697
128MUSK0.12545358

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58931652
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.93206234
3Mismatch repair_Homo sapiens_hsa034303.83300735
4RNA transport_Homo sapiens_hsa030133.55295826
5Spliceosome_Homo sapiens_hsa030403.41753728
6Proteasome_Homo sapiens_hsa030503.27051011
7RNA polymerase_Homo sapiens_hsa030203.23890612
8Ribosome_Homo sapiens_hsa030103.17621031
9Homologous recombination_Homo sapiens_hsa034403.01888404
10Base excision repair_Homo sapiens_hsa034102.79761096
11Nucleotide excision repair_Homo sapiens_hsa034202.69069379
12Fanconi anemia pathway_Homo sapiens_hsa034602.64935479
13Cell cycle_Homo sapiens_hsa041102.64080852
14Basal transcription factors_Homo sapiens_hsa030222.61681652
15Pyrimidine metabolism_Homo sapiens_hsa002402.54430395
16Oxidative phosphorylation_Homo sapiens_hsa001902.52673503
17One carbon pool by folate_Homo sapiens_hsa006702.29760520
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26101772
19mRNA surveillance pathway_Homo sapiens_hsa030152.13464320
20Vitamin B6 metabolism_Homo sapiens_hsa007502.07818854
21RNA degradation_Homo sapiens_hsa030182.06918146
22Non-homologous end-joining_Homo sapiens_hsa034501.76257089
23Purine metabolism_Homo sapiens_hsa002301.57868298
24p53 signaling pathway_Homo sapiens_hsa041151.48276041
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.44754969
26Pentose phosphate pathway_Homo sapiens_hsa000301.42949666
27Selenocompound metabolism_Homo sapiens_hsa004501.38096582
28Alzheimers disease_Homo sapiens_hsa050101.32612346
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32314601
30Oocyte meiosis_Homo sapiens_hsa041141.29600562
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22773195
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17349673
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16384700
34Biosynthesis of amino acids_Homo sapiens_hsa012301.10259299
35Antigen processing and presentation_Homo sapiens_hsa046121.03558802
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03069917
37Huntingtons disease_Homo sapiens_hsa050160.98446483
38Systemic lupus erythematosus_Homo sapiens_hsa053220.95085666
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89549336
40Pyruvate metabolism_Homo sapiens_hsa006200.87216035
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85222286
42Herpes simplex infection_Homo sapiens_hsa051680.84391951
43Carbon metabolism_Homo sapiens_hsa012000.78393138
44Viral carcinogenesis_Homo sapiens_hsa052030.76777434
45Sulfur relay system_Homo sapiens_hsa041220.75629021
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75576821
47Folate biosynthesis_Homo sapiens_hsa007900.72366967
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71900647
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67314976
50Fructose and mannose metabolism_Homo sapiens_hsa000510.66898159
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.66304520
52Glutathione metabolism_Homo sapiens_hsa004800.65253172
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.64599092
54HTLV-I infection_Homo sapiens_hsa051660.62317841
55Fatty acid elongation_Homo sapiens_hsa000620.61828585
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60683726
57Cardiac muscle contraction_Homo sapiens_hsa042600.60587526
58Linoleic acid metabolism_Homo sapiens_hsa005910.55301393
59Legionellosis_Homo sapiens_hsa051340.55136675
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46575084
61Thyroid cancer_Homo sapiens_hsa052160.46338486
62Steroid biosynthesis_Homo sapiens_hsa001000.44335407
63Protein export_Homo sapiens_hsa030600.42800390
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42667377
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41043063
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38005871
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37897419
68Phototransduction_Homo sapiens_hsa047440.35910956
69Glucagon signaling pathway_Homo sapiens_hsa049220.33384621
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32420135
71Small cell lung cancer_Homo sapiens_hsa052220.32244457
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.31893895
73Basal cell carcinoma_Homo sapiens_hsa052170.30823442
74Sulfur metabolism_Homo sapiens_hsa009200.30220041
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30208418
76N-Glycan biosynthesis_Homo sapiens_hsa005100.30096360
77Metabolic pathways_Homo sapiens_hsa011000.29979019
78MicroRNAs in cancer_Homo sapiens_hsa052060.29012421
79HIF-1 signaling pathway_Homo sapiens_hsa040660.24882527
80Propanoate metabolism_Homo sapiens_hsa006400.24583551
81Hippo signaling pathway_Homo sapiens_hsa043900.24331457
82Arachidonic acid metabolism_Homo sapiens_hsa005900.24077892
83TGF-beta signaling pathway_Homo sapiens_hsa043500.23551194
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22364058
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21398823
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21395096
87Parkinsons disease_Homo sapiens_hsa050120.20578705
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19960127
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19711064
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19524586
91Measles_Homo sapiens_hsa051620.19436986
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19248745
93Alcoholism_Homo sapiens_hsa050340.19079357
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18806197
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18531596
96Hedgehog signaling pathway_Homo sapiens_hsa043400.18077002
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.18046903
98Influenza A_Homo sapiens_hsa051640.17734859
99Renin-angiotensin system_Homo sapiens_hsa046140.17297676
100Apoptosis_Homo sapiens_hsa042100.15508788
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.14800066
102Galactose metabolism_Homo sapiens_hsa000520.13482528
103Vitamin digestion and absorption_Homo sapiens_hsa049770.13297969
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11972974
105Hematopoietic cell lineage_Homo sapiens_hsa046400.11612137
106Notch signaling pathway_Homo sapiens_hsa043300.10687004
107Primary immunodeficiency_Homo sapiens_hsa053400.10577166
108Fat digestion and absorption_Homo sapiens_hsa049750.10405576
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09928589
110Arginine and proline metabolism_Homo sapiens_hsa003300.09427775
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08932857
112Fatty acid biosynthesis_Homo sapiens_hsa000610.08283128
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07098207
114mTOR signaling pathway_Homo sapiens_hsa041500.06651770
115Wnt signaling pathway_Homo sapiens_hsa043100.06553760
116Shigellosis_Homo sapiens_hsa051310.06164656
117Hepatitis B_Homo sapiens_hsa051610.05201400
118Glycerolipid metabolism_Homo sapiens_hsa005610.04826707
119Pathways in cancer_Homo sapiens_hsa052000.04546114
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.03924804
121Acute myeloid leukemia_Homo sapiens_hsa052210.03868264
122T cell receptor signaling pathway_Homo sapiens_hsa046600.03287614
123Peroxisome_Homo sapiens_hsa041460.03266631
124Regulation of autophagy_Homo sapiens_hsa041400.02559604
125Graft-versus-host disease_Homo sapiens_hsa053320.01895939
126Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0282724
127Collecting duct acid secretion_Homo sapiens_hsa04966-0.0259282
128Allograft rejection_Homo sapiens_hsa05330-0.0235697
129Viral myocarditis_Homo sapiens_hsa05416-0.0223661
130Fatty acid metabolism_Homo sapiens_hsa01212-0.0163520
131Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0100468

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