LYARP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.63945658
2ATP synthesis coupled proton transport (GO:0015986)5.25903587
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.25903587
4short-term memory (GO:0007614)5.13202429
5regulation of hypersensitivity (GO:0002883)5.05771299
6regulation of cilium movement (GO:0003352)5.01241924
7organelle disassembly (GO:1903008)4.70979175
8gamma-aminobutyric acid transport (GO:0015812)4.62537209
9regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.49301706
10microtubule depolymerization (GO:0007019)4.29061689
11sodium-independent organic anion transport (GO:0043252)4.25255831
12negative regulation of cell aging (GO:0090344)3.93542994
13positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.83373208
14immunoglobulin mediated immune response (GO:0016064)3.79016326
15DNA deamination (GO:0045006)3.68702609
16positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.66290285
17protein complex biogenesis (GO:0070271)3.62685982
18regulation of sarcomere organization (GO:0060297)3.59476062
19retinal cone cell development (GO:0046549)3.52126865
20microtubule severing (GO:0051013)3.50463226
21rRNA catabolic process (GO:0016075)3.49366000
22protein localization to cilium (GO:0061512)3.45231657
23regulation of macrophage chemotaxis (GO:0010758)3.44896959
24DNA demethylation (GO:0080111)3.42061910
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40066804
26negative regulation of amino acid transport (GO:0051956)3.37042858
27negative regulation of heart rate (GO:0010459)3.36708247
28one-carbon compound transport (GO:0019755)3.36127531
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33914774
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.33914774
31NADH dehydrogenase complex assembly (GO:0010257)3.33914774
32mast cell activation involved in immune response (GO:0002279)3.32875462
33mast cell degranulation (GO:0043303)3.32875462
34positive regulation of fibroblast migration (GO:0010763)3.27715803
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26175366
36facial nerve structural organization (GO:0021612)3.20004591
37ribonucleoprotein complex disassembly (GO:0032988)3.18982566
38respiratory electron transport chain (GO:0022904)3.18497170
39protein K63-linked deubiquitination (GO:0070536)3.18316673
40electron transport chain (GO:0022900)3.17359649
413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.16698717
42purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.16698717
43mitochondrial respiratory chain complex assembly (GO:0033108)3.15554483
44centriole replication (GO:0007099)3.14941422
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13104223
46relaxation of smooth muscle (GO:0044557)3.06725890
47negative regulation of transcription regulatory region DNA binding (GO:2000678)3.05456302
48atrial cardiac muscle cell action potential (GO:0086014)3.05148528
49sulfation (GO:0051923)3.00216012
50keratinocyte development (GO:0003334)2.99629133
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96903029
52phagocytosis, engulfment (GO:0006911)2.96345916
53outer ear morphogenesis (GO:0042473)2.95909451
54positive regulation of mitochondrial fission (GO:0090141)2.94475480
55respiratory tube development (GO:0030323)2.92823844
56neuronal action potential propagation (GO:0019227)2.87510044
57phasic smooth muscle contraction (GO:0014821)2.86438258
58microtubule polymerization or depolymerization (GO:0031109)2.85452816
59serotonin receptor signaling pathway (GO:0007210)2.82844249
60multicellular organism reproduction (GO:0032504)2.82264092
61inflammatory response to antigenic stimulus (GO:0002437)2.81949264
62regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.81201187
63mature B cell differentiation involved in immune response (GO:0002313)2.80232099
64regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.79994669
65regulation of circadian sleep/wake cycle (GO:0042749)2.79994669
66DNA dealkylation (GO:0035510)2.79462602
67L-fucose catabolic process (GO:0042355)2.78469274
68fucose catabolic process (GO:0019317)2.78469274
69L-fucose metabolic process (GO:0042354)2.78469274
70regulation of glutamate secretion (GO:0014048)2.78413954
71mast cell activation (GO:0045576)2.75730415
72pantothenate metabolic process (GO:0015939)2.75218588
73mitochondrial fusion (GO:0008053)2.74831061
74negative regulation of homotypic cell-cell adhesion (GO:0034111)2.74447860
75kynurenine metabolic process (GO:0070189)2.72780040
76regulation of mononuclear cell migration (GO:0071675)2.71885428
77phagocytosis, recognition (GO:0006910)2.70478615
78cytochrome complex assembly (GO:0017004)2.70107730
79negative regulation of platelet activation (GO:0010544)2.68880415
80positive regulation of collagen biosynthetic process (GO:0032967)2.68784028
81proton transport (GO:0015992)2.65725394
82regulation of timing of cell differentiation (GO:0048505)2.64487511
83regulation of development, heterochronic (GO:0040034)2.63033782
84regulation of MHC class II biosynthetic process (GO:0045346)2.61308365
85peristalsis (GO:0030432)2.60620959
86cell migration involved in heart development (GO:0060973)2.60444153
87negative regulation of epidermal cell differentiation (GO:0045605)2.59909460
88proline transport (GO:0015824)2.59343438
89positive regulation of cGMP biosynthetic process (GO:0030828)2.59320115
90regulation of platelet aggregation (GO:0090330)2.58825271
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.58248547
92protein K11-linked ubiquitination (GO:0070979)2.57086076
93regulation of glomerular filtration (GO:0003093)2.56988487
94ATP biosynthetic process (GO:0006754)2.56629575
95cranial nerve structural organization (GO:0021604)2.56387953
96B cell mediated immunity (GO:0019724)2.56210716
97hydrogen transport (GO:0006818)2.56003437
98eyelid development in camera-type eye (GO:0061029)2.55172928
99positive regulation of collagen metabolic process (GO:0010714)2.51563600
100negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.51253347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.73114723
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.69408183
3VDR_22108803_ChIP-Seq_LS180_Human3.37698833
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71673802
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61180483
6IRF1_19129219_ChIP-ChIP_H3396_Human2.35944281
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.35012573
8EWS_26573619_Chip-Seq_HEK293_Human2.30280209
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.19752790
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19205584
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.16658189
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07880690
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04010124
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03635874
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03273132
16IGF1R_20145208_ChIP-Seq_DFB_Human2.02349919
17P300_19829295_ChIP-Seq_ESCs_Human2.01049234
18FUS_26573619_Chip-Seq_HEK293_Human1.92987789
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88606430
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86211041
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84707812
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82940512
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79567237
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.78135964
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.76740844
26ELK1_19687146_ChIP-ChIP_HELA_Human1.76244563
27TAF15_26573619_Chip-Seq_HEK293_Human1.75358321
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74083926
29BCAT_22108803_ChIP-Seq_LS180_Human1.68780709
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68488953
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.62932740
32RNF2_27304074_Chip-Seq_NSC_Mouse1.61024683
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.53927638
34GBX2_23144817_ChIP-Seq_PC3_Human1.53260011
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51626380
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.51312743
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.50494461
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48860019
39SMAD4_21799915_ChIP-Seq_A2780_Human1.46347690
40ER_23166858_ChIP-Seq_MCF-7_Human1.44606931
41EZH2_22144423_ChIP-Seq_EOC_Human1.44397798
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43894769
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42331048
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40422270
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38637712
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37670845
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37216576
48VDR_23849224_ChIP-Seq_CD4+_Human1.37120768
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36945520
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.33021652
51AR_25329375_ChIP-Seq_VCAP_Human1.32890054
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32778249
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32001305
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30745001
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.30100064
56CBP_20019798_ChIP-Seq_JUKART_Human1.29855838
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29855838
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27122452
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26937583
60CDX2_22108803_ChIP-Seq_LS180_Human1.25791519
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24978173
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.24501208
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24263913
64TP53_22573176_ChIP-Seq_HFKS_Human1.24262923
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22011067
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.22011067
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.21376568
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.21313739
69TCF4_22108803_ChIP-Seq_LS180_Human1.21120636
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19613657
71P53_22387025_ChIP-Seq_ESCs_Mouse1.19100111
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.17975229
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17241266
74SOX2_19829295_ChIP-Seq_ESCs_Human1.16587425
75NANOG_19829295_ChIP-Seq_ESCs_Human1.16587425
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16021805
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15483949
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.13924425
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.13503172
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13308434
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.12214761
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11675759
83AR_20517297_ChIP-Seq_VCAP_Human1.10951911
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10018137
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09302706
86P300_18555785_Chip-Seq_ESCs_Mouse1.08983893
87SOX2_18555785_Chip-Seq_ESCs_Mouse1.08693249
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07466581
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.07150670
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.06813570
91NFYA_21822215_ChIP-Seq_K562_Human1.05568106
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05069896
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.03684383
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03371960
95TBL1_22424771_ChIP-Seq_293T_Human1.02444038
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00730900
97TCF4_23295773_ChIP-Seq_U87_Human1.00213850
98NFYB_21822215_ChIP-Seq_K562_Human1.00162247
99OCT4_18555785_Chip-Seq_ESCs_Mouse0.99497814
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99371121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.22057348
2MP0000569_abnormal_digit_pigmentation3.08710197
3MP0002277_abnormal_respiratory_mucosa2.77091801
4MP0005360_urolithiasis2.68585144
5MP0000749_muscle_degeneration2.64728496
6MP0002909_abnormal_adrenal_gland2.58405366
7MP0005671_abnormal_response_to2.24662932
8MP0001968_abnormal_touch/_nociception2.21853053
9MP0003011_delayed_dark_adaptation2.12278563
10MP0009046_muscle_twitch2.01092556
11MP0003252_abnormal_bile_duct1.94412367
12MP0002102_abnormal_ear_morphology1.93171179
13MP0003136_yellow_coat_color1.93143311
14MP0003137_abnormal_impulse_conducting1.93031675
15MP0002736_abnormal_nociception_after1.92881624
16MP0005084_abnormal_gallbladder_morpholo1.84161469
17MP0006072_abnormal_retinal_apoptosis1.77335973
18MP0001188_hyperpigmentation1.77091896
19MP0001756_abnormal_urination1.75318332
20MP0005551_abnormal_eye_electrophysiolog1.70809445
21MP0000015_abnormal_ear_pigmentation1.69889314
22MP0002234_abnormal_pharynx_morphology1.69131065
23MP0001529_abnormal_vocalization1.68530683
24MP0001485_abnormal_pinna_reflex1.67574988
25MP0005174_abnormal_tail_pigmentation1.66167809
26MP0002733_abnormal_thermal_nociception1.64959168
27MP0001486_abnormal_startle_reflex1.63641768
28MP0005253_abnormal_eye_physiology1.59261301
29MP0002132_abnormal_respiratory_system1.58653506
30MP0001986_abnormal_taste_sensitivity1.55327355
31MP0003880_abnormal_central_pattern1.53995167
32MP0001324_abnormal_eye_pigmentation1.52488981
33MP0004215_abnormal_myocardial_fiber1.49495104
34MP0004142_abnormal_muscle_tone1.48927272
35MP0002272_abnormal_nervous_system1.48167863
36MP0005167_abnormal_blood-brain_barrier1.48025516
37MP0002928_abnormal_bile_duct1.45567384
38MP0002090_abnormal_vision1.45108572
39MP0001835_abnormal_antigen_presentation1.44195700
40MP0003787_abnormal_imprinting1.44025407
41MP0004085_abnormal_heartbeat1.43838030
42MP0000343_altered_response_to1.42646592
43MP0010386_abnormal_urinary_bladder1.41827917
44MP0005365_abnormal_bile_salt1.37691196
45MP0003195_calcinosis1.36838896
46MP0000631_abnormal_neuroendocrine_gland1.33061203
47MP0002138_abnormal_hepatobiliary_system1.31047937
48MP0009840_abnormal_foam_cell1.26844010
49MP0002163_abnormal_gland_morphology1.26616830
50MP0005595_abnormal_vascular_smooth1.24921249
51MP0008875_abnormal_xenobiotic_pharmacok1.23750840
52MP0002254_reproductive_system_inflammat1.21957998
53MP0001501_abnormal_sleep_pattern1.18521119
54MP0001970_abnormal_pain_threshold1.15791327
55MP0004134_abnormal_chest_morphology1.14158585
56MP0000920_abnormal_myelination1.12707340
57MP0002734_abnormal_mechanical_nocicepti1.11882552
58MP0002095_abnormal_skin_pigmentation1.09387674
59MP0006276_abnormal_autonomic_nervous1.08460505
60MP0004233_abnormal_muscle_weight1.06777597
61MP0003638_abnormal_response/metabolism_1.06427732
62MP0000516_abnormal_urinary_system1.05938094
63MP0005367_renal/urinary_system_phenotyp1.05938094
64MP0009745_abnormal_behavioral_response1.05796154
65MP0008007_abnormal_cellular_replicative1.04880029
66MP0002572_abnormal_emotion/affect_behav1.03924608
67MP0005386_behavior/neurological_phenoty1.02846552
68MP0004924_abnormal_behavior1.02846552
69MP0005085_abnormal_gallbladder_physiolo1.02813530
70MP0009250_abnormal_appendicular_skeleto1.01365977
71MP0003879_abnormal_hair_cell0.99939420
72MP0005391_vision/eye_phenotype0.99309666
73MP0003567_abnormal_fetal_cardiomyocyte0.96725059
74MP0002233_abnormal_nose_morphology0.96214876
75MP0000751_myopathy0.95253543
76MP0003186_abnormal_redox_activity0.94603431
77MP0006292_abnormal_olfactory_placode0.92147899
78MP0006035_abnormal_mitochondrial_morpho0.92085458
79MP0005195_abnormal_posterior_eye0.90761811
80MP0001664_abnormal_digestion0.86230454
81MP0006036_abnormal_mitochondrial_physio0.84935643
82MP0002735_abnormal_chemical_nociception0.84749123
83MP0002067_abnormal_sensory_capabilities0.84160442
84MP0003868_abnormal_feces_composition0.82407169
85MP0001299_abnormal_eye_distance/0.80888571
86MP0005646_abnormal_pituitary_gland0.80037476
87MP0003635_abnormal_synaptic_transmissio0.78241206
88MP0005377_hearing/vestibular/ear_phenot0.77885760
89MP0003878_abnormal_ear_physiology0.77885760
90MP0008961_abnormal_basal_metabolism0.76745145
91MP0001905_abnormal_dopamine_level0.75753757
92MP0001286_abnormal_eye_development0.75064772
93MP0002210_abnormal_sex_determination0.74678488
94MP0002184_abnormal_innervation0.74003216
95MP0004742_abnormal_vestibular_system0.73489471
96MP0002752_abnormal_somatic_nervous0.71594780
97MP0000653_abnormal_sex_gland0.67953696
98MP0000230_abnormal_systemic_arterial0.66695711
99MP0005332_abnormal_amino_acid0.65518696
100MP0002063_abnormal_learning/memory/cond0.64518594

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.57478499
2Absent speech (HP:0001344)3.96008435
3Systemic lupus erythematosus (HP:0002725)3.50063537
4Cerebellar dysplasia (HP:0007033)3.49146634
5Renal cortical cysts (HP:0000803)3.32416212
6Amelogenesis imperfecta (HP:0000705)3.29842626
7Ulnar claw (HP:0001178)3.28953521
8Lissencephaly (HP:0001339)3.17556036
9Hyperventilation (HP:0002883)3.15483535
10Hepatic necrosis (HP:0002605)3.06714683
11Calf muscle hypertrophy (HP:0008981)3.05591020
12Nephronophthisis (HP:0000090)3.04408040
13Congenital, generalized hypertrichosis (HP:0004540)3.03600689
14Pachygyria (HP:0001302)3.00361657
15Hypoplasia of the pons (HP:0012110)2.99320533
16Mitochondrial inheritance (HP:0001427)2.97953240
17Generalized aminoaciduria (HP:0002909)2.93631013
18Agitation (HP:0000713)2.83717858
19Limb-girdle muscle atrophy (HP:0003797)2.82351854
20Abnormality of the renal medulla (HP:0100957)2.81667904
21Aplasia/Hypoplasia involving the musculature (HP:0001460)2.78606140
22Broad alveolar ridges (HP:0000187)2.78134881
23Abnormality of the pons (HP:0007361)2.78018141
24Retinal dysplasia (HP:0007973)2.78005420
25Attenuation of retinal blood vessels (HP:0007843)2.75677078
26Abnormality of the renal cortex (HP:0011035)2.71542984
27Gaze-evoked nystagmus (HP:0000640)2.71540675
28Pancreatic cysts (HP:0001737)2.70156333
29Hepatocellular necrosis (HP:0001404)2.69791862
30Medial flaring of the eyebrow (HP:0010747)2.69122253
31Abnormality of dental color (HP:0011073)2.68043773
32Limb hypertonia (HP:0002509)2.66762294
3311 pairs of ribs (HP:0000878)2.65686798
34Muscle hypertrophy of the lower extremities (HP:0008968)2.63892358
35Abnormality of the musculature of the pelvis (HP:0001469)2.63546613
36Abnormality of the hip-girdle musculature (HP:0001445)2.63546613
37Tachypnea (HP:0002789)2.60780751
38Abnormal spermatogenesis (HP:0008669)2.56617720
39Type I transferrin isoform profile (HP:0003642)2.51771328
40Depressed nasal tip (HP:0000437)2.50373973
41Severe muscular hypotonia (HP:0006829)2.49749113
42Abnormality of midbrain morphology (HP:0002418)2.49141989
43Molar tooth sign on MRI (HP:0002419)2.49141989
44Shoulder girdle muscle weakness (HP:0003547)2.48467879
45Degeneration of anterior horn cells (HP:0002398)2.45372520
46Abnormality of the anterior horn cell (HP:0006802)2.45372520
47Fibular hypoplasia (HP:0003038)2.43173447
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42858429
49Abnormality of renal resorption (HP:0011038)2.42733990
50Intestinal atresia (HP:0011100)2.40331920
51Pelvic girdle muscle weakness (HP:0003749)2.39190422
52Neonatal respiratory distress (HP:0002643)2.37617939
53Glomerulonephritis (HP:0000099)2.35789340
54Neonatal death (HP:0003811)2.33572136
55Hemiplegia (HP:0002301)2.32598416
56Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.27823092
57Fair hair (HP:0002286)2.22845564
58Posterior subcapsular cataract (HP:0007787)2.22664650
59Abnormality of the fovea (HP:0000493)2.22109232
60Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21649185
61Increased CSF lactate (HP:0002490)2.21392452
62Esophageal neoplasm (HP:0100751)2.21355073
63Neoplasm of head and neck (HP:0012288)2.21355073
64Acute necrotizing encephalopathy (HP:0006965)2.20615125
65Hypoglycemic coma (HP:0001325)2.20486171
66Retinal atrophy (HP:0001105)2.15268701
67Polyuria (HP:0000103)2.13030436
68Choroideremia (HP:0001139)2.08682142
69Scotoma (HP:0000575)2.08238853
70Muscular dystrophy (HP:0003560)2.07773062
71Acute encephalopathy (HP:0006846)2.07525615
72Nonprogressive disorder (HP:0003680)2.07489060
73Anterior segment dysgenesis (HP:0007700)2.07226704
74Generalized tonic-clonic seizures (HP:0002069)2.05908929
75Nephrogenic diabetes insipidus (HP:0009806)2.05885026
76Hemiparesis (HP:0001269)2.05833642
77Abnormality of the calf musculature (HP:0001430)2.03513455
78Hyperglycinuria (HP:0003108)1.99372264
79Polydipsia (HP:0001959)1.98381249
80Abnormal drinking behavior (HP:0030082)1.98381249
81Epileptic encephalopathy (HP:0200134)1.97969625
82Glycosuria (HP:0003076)1.97673269
83Abnormality of urine glucose concentration (HP:0011016)1.97673269
84Congenital sensorineural hearing impairment (HP:0008527)1.96908533
85Congenital primary aphakia (HP:0007707)1.93618659
86Increased hepatocellular lipid droplets (HP:0006565)1.90572235
87Gait imbalance (HP:0002141)1.89275923
88Reduced antithrombin III activity (HP:0001976)1.88858286
89Buphthalmos (HP:0000557)1.88176594
90Concave nail (HP:0001598)1.87149329
91Brittle hair (HP:0002299)1.86990362
92Lipid accumulation in hepatocytes (HP:0006561)1.85050789
93Abnormality of the ileum (HP:0001549)1.84786024
94Abolished electroretinogram (ERG) (HP:0000550)1.83656676
95Abnormality of the alveolar ridges (HP:0006477)1.82070662
96Chorioretinal atrophy (HP:0000533)1.81428300
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.79792101
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79792101
99Prominent supraorbital ridges (HP:0000336)1.79582891
100Progressive macrocephaly (HP:0004481)1.79503415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L3.97737725
2TRIM283.83458906
3BMPR23.82268054
4ADRBK23.40897599
5VRK23.22452061
6GRK13.16132360
7BCKDK2.84119797
8NUAK12.28541407
9SRPK12.04212534
10CLK11.96266576
11VRK11.83150014
12MARK11.80930868
13NME11.68532433
14EPHA41.66471639
15RPS6KA41.61958488
16MAP4K21.60465785
17ERBB31.59822664
18NEK61.40248265
19PDK21.37202959
20MAPK131.29873203
21STK381.29496541
22FRK1.28014278
23TAOK11.27393828
24MAP3K31.26684896
25WEE11.22660239
26PRKCG1.15012789
27DYRK31.14747003
28IKBKB1.14532914
29MAP2K71.07828888
30TLK11.04461775
31WNK31.03031688
32SGK21.01844857
33PINK11.01651855
34MAP3K41.01578021
35MKNK21.01155465
36PAK30.98394842
37MAPK150.98195843
38OXSR10.97882168
39BMPR1B0.97834428
40UHMK10.97531972
41RIPK40.97026494
42KIT0.96809398
43MKNK10.86274621
44RPS6KA50.81329316
45MAP3K140.78541100
46PRKG20.78231347
47CHUK0.77499308
48PRKG10.77481550
49BLK0.70644621
50TNIK0.68647055
51LMTK20.67000554
52CASK0.63979601
53WNK40.63092543
54RPS6KA60.62737647
55CAMK2B0.60112348
56SGK2230.58863604
57SGK4940.58863604
58PRKCE0.58835067
59MAP3K120.58107959
60ADRBK10.57717345
61CSNK1G20.56824032
62SGK30.56179015
63ACVR1B0.54857272
64RPS6KL10.54723225
65RPS6KC10.54723225
66AKT30.53577853
67BCR0.53424451
68PNCK0.53412742
69INSRR0.52207557
70PRKCB0.51494338
71PRKACB0.48847835
72DYRK1A0.47650926
73EPHA30.46781929
74EPHB20.46687838
75CDK60.44863214
76JAK10.44695816
77CAMK2G0.44629629
78MAPK40.43499252
79ROCK10.43394146
80NEK10.41872938
81DYRK20.41448164
82PLK10.40802018
83ITK0.40766058
84STK390.40694294
85CSNK1A10.40585330
86CAMK2A0.40549211
87CDC70.39803905
88CSF1R0.39603929
89STK100.37821702
90MINK10.36736954
91ABL10.36153864
92TEC0.35976373
93PRKCQ0.35453289
94CAMK40.34613426
95CSNK1D0.34603186
96LYN0.34601277
97GSK3A0.34393466
98PRKACA0.34289765
99OBSCN0.32908470
100ERBB40.32394358

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.23678626
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.46187605
3Staphylococcus aureus infection_Homo sapiens_hsa051503.31033553
4Oxidative phosphorylation_Homo sapiens_hsa001903.11754782
5Graft-versus-host disease_Homo sapiens_hsa053322.69680221
6Allograft rejection_Homo sapiens_hsa053302.62680933
7Autoimmune thyroid disease_Homo sapiens_hsa053202.50549563
8Type I diabetes mellitus_Homo sapiens_hsa049402.39868630
9Parkinsons disease_Homo sapiens_hsa050122.31625907
10Phototransduction_Homo sapiens_hsa047442.21029331
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14658292
12Butanoate metabolism_Homo sapiens_hsa006502.07471929
13Sulfur metabolism_Homo sapiens_hsa009201.98013124
14Rheumatoid arthritis_Homo sapiens_hsa053231.78205141
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65659040
16Huntingtons disease_Homo sapiens_hsa050161.65622209
17Cardiac muscle contraction_Homo sapiens_hsa042601.64807802
18Fanconi anemia pathway_Homo sapiens_hsa034601.63727918
19Homologous recombination_Homo sapiens_hsa034401.63043581
20Antigen processing and presentation_Homo sapiens_hsa046121.54910899
21Alzheimers disease_Homo sapiens_hsa050101.36745360
22Histidine metabolism_Homo sapiens_hsa003401.36712011
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35673248
24Nitrogen metabolism_Homo sapiens_hsa009101.34711096
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33862350
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32175049
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28634159
28Leishmaniasis_Homo sapiens_hsa051401.27892178
29Circadian rhythm_Homo sapiens_hsa047101.26176672
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24715265
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22773902
32Circadian entrainment_Homo sapiens_hsa047131.21614334
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21594009
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21103415
35Proteasome_Homo sapiens_hsa030501.14044205
36Olfactory transduction_Homo sapiens_hsa047401.12871191
37Viral myocarditis_Homo sapiens_hsa054161.09054414
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08992144
39Propanoate metabolism_Homo sapiens_hsa006401.07591216
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06813403
41Complement and coagulation cascades_Homo sapiens_hsa046101.05996730
42Nicotine addiction_Homo sapiens_hsa050331.05177657
43Tryptophan metabolism_Homo sapiens_hsa003801.04971441
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04082295
45Systemic lupus erythematosus_Homo sapiens_hsa053221.02892102
46ABC transporters_Homo sapiens_hsa020101.01807699
47RNA polymerase_Homo sapiens_hsa030201.01367485
48Phagosome_Homo sapiens_hsa041450.99075566
49Collecting duct acid secretion_Homo sapiens_hsa049660.98095606
50Taste transduction_Homo sapiens_hsa047420.96591275
51Renin secretion_Homo sapiens_hsa049240.89540524
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.87599608
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86802694
54Ribosome_Homo sapiens_hsa030100.84978624
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84073243
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.83715622
57Morphine addiction_Homo sapiens_hsa050320.81352551
58RNA degradation_Homo sapiens_hsa030180.81128588
59Linoleic acid metabolism_Homo sapiens_hsa005910.76106984
60beta-Alanine metabolism_Homo sapiens_hsa004100.74806771
61GABAergic synapse_Homo sapiens_hsa047270.68549549
62Purine metabolism_Homo sapiens_hsa002300.68375797
63Basal transcription factors_Homo sapiens_hsa030220.67782721
64Chemical carcinogenesis_Homo sapiens_hsa052040.64771304
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63495967
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63012246
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62528973
68Salivary secretion_Homo sapiens_hsa049700.62281758
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62113910
70Retinol metabolism_Homo sapiens_hsa008300.60207131
71Spliceosome_Homo sapiens_hsa030400.60052775
72Peroxisome_Homo sapiens_hsa041460.59168718
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57034701
74Pyruvate metabolism_Homo sapiens_hsa006200.55593224
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54594999
76Serotonergic synapse_Homo sapiens_hsa047260.51268050
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49684143
78Nucleotide excision repair_Homo sapiens_hsa034200.48429977
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47354283
80Legionellosis_Homo sapiens_hsa051340.46481876
81Folate biosynthesis_Homo sapiens_hsa007900.45203292
82Tuberculosis_Homo sapiens_hsa051520.45072667
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43511846
84Sulfur relay system_Homo sapiens_hsa041220.41087103
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40275772
86Fatty acid degradation_Homo sapiens_hsa000710.40269775
87Glutamatergic synapse_Homo sapiens_hsa047240.36530347
88Gastric acid secretion_Homo sapiens_hsa049710.36172219
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34210506
90Synaptic vesicle cycle_Homo sapiens_hsa047210.33858144
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.33434835
92Toxoplasmosis_Homo sapiens_hsa051450.33126950
93Arginine and proline metabolism_Homo sapiens_hsa003300.33071074
94Pancreatic secretion_Homo sapiens_hsa049720.32210326
95Long-term depression_Homo sapiens_hsa047300.31699015
96cAMP signaling pathway_Homo sapiens_hsa040240.31354417
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30841035
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30632416
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.28917766
100Caffeine metabolism_Homo sapiens_hsa002320.27535302

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