LYG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a SLT domain, a protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)8.57990378
2adhesion of symbiont to host (GO:0044406)8.55678489
3citrulline biosynthetic process (GO:0019240)8.02232379
4establishment of skin barrier (GO:0061436)7.85742465
5hair follicle morphogenesis (GO:0031069)7.60561973
6regulation of water loss via skin (GO:0033561)6.91688686
7keratinocyte differentiation (GO:0030216)6.75871512
8intermediate filament cytoskeleton organization (GO:0045104)6.68097937
9epidermis development (GO:0008544)6.61019078
10intermediate filament-based process (GO:0045103)6.47315295
11bundle of His cell to Purkinje myocyte communication (GO:0086069)6.12747222
12molting cycle process (GO:0022404)5.59446380
13hair cycle process (GO:0022405)5.59446380
14skin morphogenesis (GO:0043589)5.36704238
15hemidesmosome assembly (GO:0031581)5.35935514
16epidermal cell differentiation (GO:0009913)5.30800135
17citrulline metabolic process (GO:0000052)5.23618878
18protein polyglutamylation (GO:0018095)5.01445680
19multicellular organismal water homeostasis (GO:0050891)4.66286321
20peptidyl-arginine modification (GO:0018195)4.55890142
21tooth mineralization (GO:0034505)4.51902666
22keratinocyte development (GO:0003334)4.49564546
23nonmotile primary cilium assembly (GO:0035058)4.15215207
24hair follicle development (GO:0001942)4.09032517
25presynaptic membrane assembly (GO:0097105)4.00096760
26molting cycle (GO:0042303)30.4980902
27hair cycle (GO:0042633)30.4980902
28intraciliary transport (GO:0042073)3.84255053
29water homeostasis (GO:0030104)3.80451993
30bone trabecula formation (GO:0060346)3.79106169
31fatty acid elongation (GO:0030497)3.71845002
32ectoderm development (GO:0007398)3.67180649
33gamma-aminobutyric acid transport (GO:0015812)3.65698488
34response to pheromone (GO:0019236)3.65611841
35negative regulation of keratinocyte proliferation (GO:0010839)3.61998502
36respiratory chain complex IV assembly (GO:0008535)3.60579989
37regulation of cilium movement (GO:0003352)3.59797764
38positive regulation of hair follicle development (GO:0051798)3.57076787
39positive regulation of hair cycle (GO:0042635)3.57076787
40protein localization to cilium (GO:0061512)3.56412467
41regulation of hexokinase activity (GO:1903299)3.54864986
42regulation of glucokinase activity (GO:0033131)3.54864986
43replication fork processing (GO:0031297)3.54033230
44neural tube formation (GO:0001841)3.43588282
45regulation of hair follicle development (GO:0051797)3.38329117
46positive regulation of meiosis (GO:0045836)3.37044658
47anterograde synaptic vesicle transport (GO:0048490)3.32398023
48negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.31706799
49gap junction assembly (GO:0016264)3.29213282
50cilium morphogenesis (GO:0060271)3.27922421
51olfactory bulb development (GO:0021772)3.26204048
52cilium organization (GO:0044782)3.26086066
53cilium assembly (GO:0042384)3.25604986
54protein complex biogenesis (GO:0070271)3.23998339
55inositol phosphate catabolic process (GO:0071545)3.23030364
56presynaptic membrane organization (GO:0097090)3.22314138
57epithelium development (GO:0060429)3.20242751
58cytochrome complex assembly (GO:0017004)3.19576302
59platelet dense granule organization (GO:0060155)3.18858639
60cellular ketone body metabolic process (GO:0046950)3.15895437
61regulation of hair cycle (GO:0042634)3.14675799
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.14542948
63positive regulation of meiotic cell cycle (GO:0051446)3.12487233
64pyrimidine nucleobase catabolic process (GO:0006208)3.11202919
65regulation of keratinocyte differentiation (GO:0045616)3.10971898
66mitochondrial respiratory chain complex assembly (GO:0033108)3.09632549
67behavioral response to nicotine (GO:0035095)3.07399300
68water-soluble vitamin biosynthetic process (GO:0042364)3.07378722
69synapsis (GO:0007129)3.04810037
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04566358
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.04566358
72NADH dehydrogenase complex assembly (GO:0010257)3.04566358
73epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.02896782
74regulation of timing of cell differentiation (GO:0048505)2.98256547
75phosphatidylinositol acyl-chain remodeling (GO:0036149)2.97758978
76DNA double-strand break processing (GO:0000729)2.97063571
77ketone body metabolic process (GO:1902224)2.95392586
78atrioventricular valve morphogenesis (GO:0003181)2.94857714
79keratinocyte proliferation (GO:0043616)2.94422161
80eye photoreceptor cell differentiation (GO:0001754)2.91854714
81photoreceptor cell differentiation (GO:0046530)2.91854714
82retinal cone cell development (GO:0046549)2.91566360
83S-adenosylmethionine metabolic process (GO:0046500)2.91324615
84inner ear receptor stereocilium organization (GO:0060122)2.88627783
85ubiquinone metabolic process (GO:0006743)2.88109541
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87822616
87branched-chain amino acid catabolic process (GO:0009083)2.86280165
88nucleobase catabolic process (GO:0046113)2.81971340
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81916716
90single strand break repair (GO:0000012)2.81832533
91epithelial cilium movement (GO:0003351)2.79335479
92positive regulation of epidermis development (GO:0045684)2.78875784
93negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77585149
94cell surface receptor signaling pathway involved in heart development (GO:0061311)2.77055413
95C4-dicarboxylate transport (GO:0015740)2.76192479
96axoneme assembly (GO:0035082)2.75979036
97protein K11-linked deubiquitination (GO:0035871)2.75609175
98lymph vessel development (GO:0001945)2.75043543
99ventricular cardiac muscle cell action potential (GO:0086005)2.73126535
100lactate metabolic process (GO:0006089)2.70984840
101limb bud formation (GO:0060174)2.70926348
102brain morphogenesis (GO:0048854)2.70900134
103negative regulation of protein localization to plasma membrane (GO:1903077)2.70300909
104regulation of mesenchymal cell apoptotic process (GO:2001053)2.66470855
105negative regulation of cell fate specification (GO:0009996)2.65075782
106seminiferous tubule development (GO:0072520)2.64866710
107regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.63657452
108cranial suture morphogenesis (GO:0060363)2.63007234
109positive regulation of amino acid transport (GO:0051957)2.62458075
110regulation of development, heterochronic (GO:0040034)2.59700362
111phosphatidylserine acyl-chain remodeling (GO:0036150)2.59053799
112regulation of meiosis I (GO:0060631)2.59029764
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58526255
114skin development (GO:0043588)2.57987433
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56634146
116regulation of protein glycosylation (GO:0060049)2.54137444
117ubiquinone biosynthetic process (GO:0006744)2.53535820
118regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52465783
119photoreceptor cell maintenance (GO:0045494)2.51982456
120positive regulation of glycolytic process (GO:0045821)2.51448034
121glycerophospholipid catabolic process (GO:0046475)2.50540519
122cellular component assembly involved in morphogenesis (GO:0010927)2.50358983
123reciprocal meiotic recombination (GO:0007131)2.48335290
124reciprocal DNA recombination (GO:0035825)2.48335290
125dopamine transport (GO:0015872)2.47849530
126regulation of acyl-CoA biosynthetic process (GO:0050812)2.46966129
127histone H2A acetylation (GO:0043968)2.46583245
128regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43690772
129polyol catabolic process (GO:0046174)2.43650074
130regulation of epidermis development (GO:0045682)2.43559316
131DNA damage response, detection of DNA damage (GO:0042769)2.43461301
132phosphorylated carbohydrate dephosphorylation (GO:0046838)2.43200170
133inositol phosphate dephosphorylation (GO:0046855)2.43200170
134wound healing, spreading of epidermal cells (GO:0035313)2.42436839
135signal peptide processing (GO:0006465)2.42341536
136regulation of mitotic spindle checkpoint (GO:1903504)2.41286840
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.41286840
138kidney morphogenesis (GO:0060993)2.40944257
139outflow tract septum morphogenesis (GO:0003148)2.40931800
140prenylation (GO:0097354)2.40106779
141protein prenylation (GO:0018342)2.40106779
142regulation of DNA endoreduplication (GO:0032875)2.39623304
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39260582
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.39260582
145regulation of epidermal cell differentiation (GO:0045604)2.38498933
146regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37975751
147sperm motility (GO:0030317)2.37894606
148glycosphingolipid biosynthetic process (GO:0006688)2.37058665
149recombinational repair (GO:0000725)2.36542425
150cornea development in camera-type eye (GO:0061303)2.36244454
151negative regulation of translation, ncRNA-mediated (GO:0040033)2.35582102
152regulation of translation, ncRNA-mediated (GO:0045974)2.35582102
153negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35582102
154acrosome reaction (GO:0007340)2.35296723
155DNA deamination (GO:0045006)2.34217411
156aldehyde catabolic process (GO:0046185)2.33410822
157double-strand break repair via homologous recombination (GO:0000724)2.32692332
158non-canonical Wnt signaling pathway (GO:0035567)2.32230862
159regulation of heart rate by cardiac conduction (GO:0086091)2.32201000
160negative regulation of epidermis development (GO:0045683)2.28431528
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.27492143
162epithelial cell-cell adhesion (GO:0090136)2.26046505
163phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.23268172
164regulation of cardioblast differentiation (GO:0051890)2.22768303
165cell communication involved in cardiac conduction (GO:0086065)2.21352313
166G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.19983249
167establishment of planar polarity (GO:0001736)2.19793284
168establishment of tissue polarity (GO:0007164)2.19793284
169myotube differentiation (GO:0014902)2.19145391
170positive regulation of epidermal cell differentiation (GO:0045606)2.18778582
171regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.18419384
172regulation of keratinocyte proliferation (GO:0010837)2.15728535
173coronary vasculature morphogenesis (GO:0060977)2.10957802
174regulation of cardioblast proliferation (GO:0003264)2.06518453
175regulation of secondary heart field cardioblast proliferation (GO:0003266)2.06518453
176ephrin receptor signaling pathway (GO:0048013)2.04916753
177very long-chain fatty acid metabolic process (GO:0000038)2.03676988
178regulation of ruffle assembly (GO:1900027)2.01968794
179lateral sprouting from an epithelium (GO:0060601)2.01446361
180regulation of cell fate specification (GO:0042659)2.00634523
181keratinization (GO:0031424)12.2207220
182desmosome organization (GO:0002934)12.1861683
183intermediate filament organization (GO:0045109)11.7257851
184virion attachment to host cell (GO:0019062)10.2580755
185adhesion of symbiont to host cell (GO:0044650)10.2580755
186long-chain fatty acid biosynthetic process (GO:0042759)1.99679824
187long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.99038929
188phosphatidylserine metabolic process (GO:0006658)1.98657558
189odontogenesis of dentin-containing tooth (GO:0042475)1.97501141
190long-chain fatty-acyl-CoA metabolic process (GO:0035336)1.95718096
191eyelid development in camera-type eye (GO:0061029)1.95070370
192phosphatidylethanolamine acyl-chain remodeling (GO:0036152)1.94947335
193positive regulation of monocyte chemotaxis (GO:0090026)1.94609994
194chondrocyte development (GO:0002063)1.91475197
195cell-substrate junction assembly (GO:0007044)1.91399384
196craniofacial suture morphogenesis (GO:0097094)1.91280305
197outer ear morphogenesis (GO:0042473)1.90028917
198cardiac right ventricle morphogenesis (GO:0003215)1.88172482
199regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.88125944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.92133245
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.52084128
3IGF1R_20145208_ChIP-Seq_DFB_Human3.53957030
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.46653761
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.33393376
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29051435
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16832876
8ZNF274_21170338_ChIP-Seq_K562_Hela3.13224676
9GBX2_23144817_ChIP-Seq_PC3_Human3.09270721
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.99030735
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87814029
12VDR_22108803_ChIP-Seq_LS180_Human2.72408353
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59923479
14FUS_26573619_Chip-Seq_HEK293_Human2.56979821
15TAF15_26573619_Chip-Seq_HEK293_Human2.31740242
16* FLI1_27457419_Chip-Seq_LIVER_Mouse2.25868592
17P300_19829295_ChIP-Seq_ESCs_Human2.25252841
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23267200
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22357864
20EWS_26573619_Chip-Seq_HEK293_Human2.17738548
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08394944
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05296121
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04698032
24TP63_17297297_ChIP-ChIP_HaCaT_Human12.7941230
25SOX9_24532713_ChIP-Seq_HFSC_Mouse1.99746258
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.95807816
27* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94414045
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93588312
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87271720
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83020574
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80834239
32CTCF_20526341_ChIP-Seq_ESCs_Human1.77619190
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76679170
34ER_23166858_ChIP-Seq_MCF-7_Human1.75424577
35BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.75101525
36NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.71070599
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70339984
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69258193
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.63000993
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61731510
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61612372
42EGR1_19032775_ChIP-ChIP_M12_Human1.61480880
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60172452
44VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.57742092
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.57597261
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.57256791
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55394410
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54876249
49CBP_20019798_ChIP-Seq_JUKART_Human1.54876249
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.54148872
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53948319
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51960029
53AR_21572438_ChIP-Seq_LNCaP_Human1.51141511
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50407989
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50407989
56STAT3_23295773_ChIP-Seq_U87_Human1.50115005
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50096105
58AHR_22903824_ChIP-Seq_MCF-7_Human1.49739572
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.47894179
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.47877618
61* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46779742
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.46717648
63E2F1_20622854_ChIP-Seq_HELA_Human1.46427656
64TAF2_19829295_ChIP-Seq_ESCs_Human1.46038161
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45562175
66* EZH2_27294783_Chip-Seq_NPCs_Mouse1.44962535
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44141756
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.43881507
69AR_25329375_ChIP-Seq_VCAP_Human1.43256466
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43111917
71ELK1_19687146_ChIP-ChIP_HELA_Human1.42726673
72MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.42552724
73ERG_20517297_ChIP-Seq_VCAP_Human1.42003976
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41607449
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41544719
76CTCF_27219007_Chip-Seq_Bcells_Human1.38500416
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.36826691
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36662852
79TP63_22573176_ChIP-Seq_HFKS_Human1.35685091
80NANOG_20526341_ChIP-Seq_ESCs_Human1.35487184
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34211555
82* NFE2_27457419_Chip-Seq_LIVER_Mouse1.33563599
83TCF4_23295773_ChIP-Seq_U87_Human1.33425312
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.33356279
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32824413
86RACK7_27058665_Chip-Seq_MCF-7_Human1.31413024
87TP63_23658742_ChIP-Seq_EP156T_Human1.30197155
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30096435
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30096435
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29867006
91P53_21459846_ChIP-Seq_SAOS-2_Human1.29827504
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29776816
93MYC_18940864_ChIP-ChIP_HL60_Human1.29618214
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29060374
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.28463180
96* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26715918
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26693238
98TP53_18474530_ChIP-ChIP_U2OS_Human1.26169156
99SOX2_19829295_ChIP-Seq_ESCs_Human1.25998061
100NANOG_19829295_ChIP-Seq_ESCs_Human1.25998061
101TCF4_22108803_ChIP-Seq_LS180_Human1.25872532
102RNF2_27304074_Chip-Seq_NSC_Mouse1.25600074
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25257635
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.24796299
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24622010
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23926557
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23800282
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23760256
109TP53_22573176_ChIP-Seq_HFKS_Human1.22932661
110* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.22215720
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19623865
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19483687
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18858347
114RUNX2_22187159_ChIP-Seq_PCA_Human1.17098863
115* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15063956
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.14529468
117* P53_22387025_ChIP-Seq_ESCs_Mouse1.14169184
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.14002187
119GATA3_24758297_ChIP-Seq_MCF-7_Human1.13453470
120* CRX_20693478_ChIP-Seq_RETINA_Mouse1.12963451
121EZH2_22144423_ChIP-Seq_EOC_Human1.12455233
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12342703
123KLF5_25053715_ChIP-Seq_YYC3_Human1.12227509
124ATF3_27146783_Chip-Seq_COLON_Human1.11079920
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.10196626
126LXR_22292898_ChIP-Seq_THP-1_Human1.09913245
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09907416
128CEBPB_22108803_ChIP-Seq_LS180_Human1.09450453
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.07898141
130REST_21632747_ChIP-Seq_MESCs_Mouse1.07279696
131FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07232684
132FOXA1_25329375_ChIP-Seq_VCAP_Human1.07232684
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06541757
134RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06498582
135RNF2_27304074_Chip-Seq_ESCs_Mouse1.05771787
136UBF1/2_26484160_Chip-Seq_HMECs_Human1.05757906
137CDX2_22108803_ChIP-Seq_LS180_Human1.04482421
138NOTCH1_21737748_ChIP-Seq_TLL_Human1.04167131
139ZNF263_19887448_ChIP-Seq_K562_Human1.03914385
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03902552
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02903187
142GATA4_25053715_ChIP-Seq_YYC3_Human1.02361611
143RXR_22108803_ChIP-Seq_LS180_Human1.02178127
144STAT3_18555785_Chip-Seq_ESCs_Mouse1.01854993
145* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01232917
146BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01229504
147PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01202678
148SRF_21415370_ChIP-Seq_HL-1_Mouse1.00758852
149FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00670202
150EZH2_27294783_Chip-Seq_ESCs_Mouse1.00549704
151BCL6_27268052_Chip-Seq_Bcells_Human1.00151144
152GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00011351
153* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99488152
154BCOR_27268052_Chip-Seq_Bcells_Human0.98916794
155* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98814244
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.98662485
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.98209443
158SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98012221
159IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97696165
160AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97601224
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97227292
162* CMYC_18555785_Chip-Seq_ESCs_Mouse0.97220368
163* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96019845
164SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96003774
165ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95478221
166RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95419687
167EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95419687
168GATA6_21074721_ChIP-Seq_CACO-2_Human0.94902077
169P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91612070
170SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91382427
171BCAT_22108803_ChIP-Seq_LS180_Human0.91124664
172EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90867828
173SOX2_20726797_ChIP-Seq_SW620_Human0.89422300
174JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88362174
175P68_20966046_ChIP-Seq_HELA_Human0.88346537
176JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87104873
177SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86992776
178EED_16625203_ChIP-ChIP_MESCs_Mouse0.86204853
179* YY1_22570637_ChIP-Seq_MALME-3M_Human0.86202557
180PHF8_20622854_ChIP-Seq_HELA_Human0.85468099
181ERG_21242973_ChIP-ChIP_JURKAT_Human0.84090969
182NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83067791
183TCF4_18268006_ChIP-ChIP_LS174T_Human0.83020049
184SMC4_20622854_ChIP-Seq_HELA_Human0.82745693
185CJUN_26792858_Chip-Seq_BT549_Human0.82448229
186* EZH2_27304074_Chip-Seq_ESCs_Mouse0.82271491
187JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81511661
188RAC3_21632823_ChIP-Seq_H3396_Human0.81479834
189ELF1_20517297_ChIP-Seq_JURKAT_Human0.80476429
190SA1_27219007_Chip-Seq_ERYTHROID_Human0.80180064
191AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78836859
192GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78101525
193E2F1_17053090_ChIP-ChIP_MCF-7_Human0.77672862
194FOXH1_21741376_ChIP-Seq_ESCs_Human0.76049646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.73108951
2MP0002796_impaired_skin_barrier6.20503312
3MP0002098_abnormal_vibrissa_morphology6.18635053
4MP0000647_abnormal_sebaceous_gland5.73786152
5MP0005275_abnormal_skin_tensile5.67093207
6MP0000383_abnormal_hair_follicle5.34756606
7MP0010678_abnormal_skin_adnexa4.61552416
8MP0010234_abnormal_vibrissa_follicle4.45865902
9MP0000377_abnormal_hair_follicle3.85810898
10MP0000427_abnormal_hair_cycle3.84845817
11MP0005501_abnormal_skin_physiology3.80778963
12MP0003705_abnormal_hypodermis_morpholog3.13227597
13MP0002254_reproductive_system_inflammat3.02701847
14MP0003880_abnormal_central_pattern2.79896123
15MP0001986_abnormal_taste_sensitivity2.75286188
16MP0001216_abnormal_epidermal_layer2.74452324
17MP0000372_irregular_coat_pigmentation2.70298250
18MP0002938_white_spotting2.61192090
19MP0004381_abnormal_hair_follicle2.53982764
20MP0002837_dystrophic_cardiac_calcinosis2.53875358
21MP0008877_abnormal_DNA_methylation2.45382748
22MP0010771_integument_phenotype2.44975989
23MP0002102_abnormal_ear_morphology2.37196968
24MP0004947_skin_inflammation2.36992690
25MP0008058_abnormal_DNA_repair2.26975689
26MP0000569_abnormal_digit_pigmentation2.24500882
27MP0005423_abnormal_somatic_nervous2.23781199
28MP0005551_abnormal_eye_electrophysiolog2.23041625
29MP0001529_abnormal_vocalization2.21497022
30MP0001984_abnormal_olfaction2.19855236
31MP0002060_abnormal_skin_morphology2.19809815
32MP0003787_abnormal_imprinting2.19390476
33MP0006072_abnormal_retinal_apoptosis2.12616953
34MP0001243_abnormal_dermal_layer2.10623343
35MP0005253_abnormal_eye_physiology2.09956233
36MP0000367_abnormal_coat/_hair2.09674862
37MP0003453_abnormal_keratinocyte_physiol2.08361992
38MP0003195_calcinosis2.04584880
39MP0002638_abnormal_pupillary_reflex2.00857112
40MP0004270_analgesia1.85806644
41MP0000631_abnormal_neuroendocrine_gland1.84813585
42MP0005645_abnormal_hypothalamus_physiol1.84591577
43MP0009046_muscle_twitch1.84399273
44MP0005646_abnormal_pituitary_gland1.81662892
45MP0002234_abnormal_pharynx_morphology1.75721096
46MP0009780_abnormal_chondrocyte_physiolo1.68619472
47MP0008789_abnormal_olfactory_epithelium1.66998435
48MP0001968_abnormal_touch/_nociception1.66252125
49MP0005174_abnormal_tail_pigmentation1.64988626
50MP0000467_abnormal_esophagus_morphology1.64676391
51MP0002736_abnormal_nociception_after1.63979478
52MP0006292_abnormal_olfactory_placode1.61706359
53MP0003941_abnormal_skin_development1.60648843
54MP0003136_yellow_coat_color1.57493129
55MP0001486_abnormal_startle_reflex1.52304699
56MP0005409_darkened_coat_color1.51966973
57MP0009931_abnormal_skin_appearance1.47369258
58MP0000762_abnormal_tongue_morphology1.44070407
59MP0009745_abnormal_behavioral_response1.43637203
60MP0006276_abnormal_autonomic_nervous1.42643454
61MP0001661_extended_life_span1.41863609
62MP0003011_delayed_dark_adaptation1.41534053
63MP0005379_endocrine/exocrine_gland_phen1.37140249
64MP0003121_genomic_imprinting1.34389437
65MP0002928_abnormal_bile_duct1.33935019
66MP0004133_heterotaxia1.33900249
67MP0002095_abnormal_skin_pigmentation1.31069465
68MP0002163_abnormal_gland_morphology1.28772883
69MP0003566_abnormal_cell_adhesion1.27249973
70MP0004924_abnormal_behavior1.24907294
71MP0005386_behavior/neurological_phenoty1.24907294
72MP0002272_abnormal_nervous_system1.24181258
73MP0004147_increased_porphyrin_level1.20216993
74MP0001485_abnormal_pinna_reflex1.19913730
75MP0002734_abnormal_mechanical_nocicepti1.19904096
76MP0009053_abnormal_anal_canal1.17324288
77MP0005394_taste/olfaction_phenotype1.16510911
78MP0005499_abnormal_olfactory_system1.16510911
79MP0000778_abnormal_nervous_system1.16400814
80MP0001764_abnormal_homeostasis1.16368112
81MP0009379_abnormal_foot_pigmentation1.15521039
82MP0002909_abnormal_adrenal_gland1.14928868
83MP0010094_abnormal_chromosome_stability1.13774657
84MP0005084_abnormal_gallbladder_morpholo1.13350658
85MP0003718_maternal_effect1.11252100
86MP0001191_abnormal_skin_condition1.10675777
87MP0005195_abnormal_posterior_eye1.10557917
88MP0002735_abnormal_chemical_nociception1.10496326
89MP0002557_abnormal_social/conspecific_i1.10353683
90MP0002160_abnormal_reproductive_system1.09449115
91MP0002064_seizures1.04961894
92MP0008872_abnormal_physiological_respon1.04133619
93MP0006035_abnormal_mitochondrial_morpho1.01805963
94MP0001501_abnormal_sleep_pattern1.01538176
95MP0004215_abnormal_myocardial_fiber1.01148243
96MP0001346_abnormal_lacrimal_gland1.00651219
97MP0004142_abnormal_muscle_tone0.99831652
98MP0002876_abnormal_thyroid_physiology0.98457085
99MP0004185_abnormal_adipocyte_glucose0.98110809
100MP0000566_synostosis0.96427057
101MP0005391_vision/eye_phenotype0.95783007
102MP0004885_abnormal_endolymph0.95336516
103MP0002572_abnormal_emotion/affect_behav0.94810439
104MP0005389_reproductive_system_phenotype0.94183842
105MP0003698_abnormal_male_reproductive0.93830969
106MP0008438_abnormal_cutaneous_collagen0.91397307
107MP0003122_maternal_imprinting0.88372563
108MP0010386_abnormal_urinary_bladder0.87479438
109MP0001929_abnormal_gametogenesis0.87235581
110MP0003943_abnormal_hepatobiliary_system0.86995433
111MP0002752_abnormal_somatic_nervous0.86162158
112MP0005410_abnormal_fertilization0.85979369
113MP0004264_abnormal_extraembryonic_tissu0.85724497
114MP0000049_abnormal_middle_ear0.85401135
115MP0002751_abnormal_autonomic_nervous0.83455860
116MP0001970_abnormal_pain_threshold0.81345343
117MP0002067_abnormal_sensory_capabilities0.80463685
118MP0003567_abnormal_fetal_cardiomyocyte0.80157139
119MP0006036_abnormal_mitochondrial_physio0.79994413
120MP0001324_abnormal_eye_pigmentation0.78091137
121MP0001340_abnormal_eyelid_morphology0.77721417
122MP0009697_abnormal_copulation0.77715108
123MP0003635_abnormal_synaptic_transmissio0.77636037
124MP0004145_abnormal_muscle_electrophysio0.76929911
125MP0001905_abnormal_dopamine_level0.76154082
126MP0002009_preneoplasia0.69541067
127MP0001851_eye_inflammation0.64906148
128MP0010030_abnormal_orbit_morphology0.61870936
129MP0002282_abnormal_trachea_morphology0.57458172
130MP0002877_abnormal_melanocyte_morpholog0.56776073
131MP0001188_hyperpigmentation0.55562971
132MP0001784_abnormal_fluid_regulation0.55546596
133MP0005451_abnormal_body_composition0.54745344
134MP0002177_abnormal_outer_ear0.54372905
135MP0001849_ear_inflammation0.53712193
136MP0000627_abnormal_mammary_gland0.52306137
137MP0002249_abnormal_larynx_morphology0.52180250
138MP0003755_abnormal_palate_morphology0.52157353
139MP0009384_cardiac_valve_regurgitation0.50639418
140MP0002697_abnormal_eye_size0.39919689
141MP0002111_abnormal_tail_morphology0.39059392
142MP0003315_abnormal_perineum_morphology0.38960178
143MP0005248_abnormal_Harderian_gland0.38202481
144MP0005023_abnormal_wound_healing0.37929839
145MP0005075_abnormal_melanosome_morpholog0.37821668
146MP0002970_abnormal_white_adipose0.37558501
147MP0010352_gastrointestinal_tract_polyps0.35783688
148MP0004272_abnormal_basement_membrane0.35221742
149MP0003385_abnormal_body_wall0.33973091
150MP0000432_abnormal_head_morphology0.33389475
151MP0002166_altered_tumor_susceptibility0.32515887
152MP0005257_abnormal_intraocular_pressure0.29707490
153MP0002006_tumorigenesis0.29085076
154MP0003191_abnormal_cellular_cholesterol0.27926289
155MP0000678_abnormal_parathyroid_gland0.26708986
156MP0000537_abnormal_urethra_morphology0.26612977
157MP0005623_abnormal_meninges_morphology0.25461029
158MP0005367_renal/urinary_system_phenotyp0.25196306
159MP0000516_abnormal_urinary_system0.25196306
160MP0000462_abnormal_digestive_system0.22788835
161MP0003935_abnormal_craniofacial_develop0.21294451
162MP0005076_abnormal_cell_differentiation0.20523092
163MP0005666_abnormal_adipose_tissue0.19033795
164MP0004742_abnormal_vestibular_system0.17530150
165MP0003300_gastrointestinal_ulcer0.17179957
166MP0003950_abnormal_plasma_membrane0.16406292
167MP0000751_myopathy0.15994255
168MP0000613_abnormal_salivary_gland0.15877299
169MP0005508_abnormal_skeleton_morphology0.15340060
170MP0001286_abnormal_eye_development0.15226481
171MP0005503_abnormal_tendon_morphology0.14476932
172MP0002233_abnormal_nose_morphology0.14114355
173MP0006054_spinal_hemorrhage0.13376674
174MP0005375_adipose_tissue_phenotype0.12908472
175MP0000538_abnormal_urinary_bladder0.12323498
176MP0005193_abnormal_anterior_eye0.12185672
177MP0002896_abnormal_bone_mineralization0.11529317
178MP0003763_abnormal_thymus_physiology0.11452044
179MP0000733_abnormal_muscle_development0.11188744
180MP0001879_abnormal_lymphatic_vessel0.09293398
181MP0002090_abnormal_vision0.09280782
182MP0001958_emphysema0.08884657
183MP0003937_abnormal_limbs/digits/tail_de0.08282945
184MP0000465_gastrointestinal_hemorrhage0.07269792
185MP0005171_absent_coat_pigmentation0.07075921

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of hair growth rate (HP:0011363)9.31533999
2Slow-growing hair (HP:0002217)9.31533999
3Brittle hair (HP:0002299)8.47231811
4Abnormal hair laboratory examination (HP:0003328)6.56042167
5Abnormality of nail color (HP:0100643)6.51839295
6Follicular hyperkeratosis (HP:0007502)6.33662598
7Nail dystrophy (HP:0008404)6.13728162
8Fragile nails (HP:0001808)5.60500715
9Alopecia of scalp (HP:0002293)5.23612453
10Palmoplantar hyperkeratosis (HP:0000972)5.05192328
11Onycholysis (HP:0001806)4.95247118
12Increased IgE level (HP:0003212)4.91236182
13Palmar hyperkeratosis (HP:0010765)4.76540632
14Plantar hyperkeratosis (HP:0007556)4.63284368
15Fine hair (HP:0002213)4.57193277
16Right ventricular cardiomyopathy (HP:0011663)4.52493625
17Erythema (HP:0010783)4.42103480
18Abnormality of midbrain morphology (HP:0002418)4.39138707
19Molar tooth sign on MRI (HP:0002419)4.39138707
20True hermaphroditism (HP:0010459)4.37026168
21Pancreatic cysts (HP:0001737)4.25725086
22Thick nail (HP:0001805)4.24596153
23Pancreatic fibrosis (HP:0100732)4.15936599
24Sparse eyelashes (HP:0000653)4.13885447
25Congenital, generalized hypertrichosis (HP:0004540)4.12806147
26Nephronophthisis (HP:0000090)3.81223547
27Intestinal atresia (HP:0011100)3.76973168
28Medial flaring of the eyebrow (HP:0010747)3.52636821
29Oral leukoplakia (HP:0002745)3.48188154
30Abnormality of the frontal sinuses (HP:0002687)3.26671271
31Chronic hepatic failure (HP:0100626)3.25246034
32Abnormality of the renal medulla (HP:0100957)3.22192488
33Erythroderma (HP:0001019)3.21859541
34Milia (HP:0001056)3.20377725
35Parakeratosis (HP:0001036)3.18417948
36Amelogenesis imperfecta (HP:0000705)3.16781046
37Cystic liver disease (HP:0006706)3.12549154
38Abnormal biliary tract physiology (HP:0012439)3.09247520
39Bile duct proliferation (HP:0001408)3.09247520
40Gait imbalance (HP:0002141)3.07231464
41Ketoacidosis (HP:0001993)3.04860123
42Congenital primary aphakia (HP:0007707)3.03519749
43Volvulus (HP:0002580)2.88112529
44Congenital ichthyosiform erythroderma (HP:0007431)2.81391555
45Curly hair (HP:0002212)2.76794546
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.76625444
47Hyperinsulinemic hypoglycemia (HP:0000825)2.74461398
48Aplasia cutis congenita (HP:0001057)2.72262661
49Abnormality of the renal cortex (HP:0011035)2.71589721
50Nephrogenic diabetes insipidus (HP:0009806)2.71052038
51Genital tract atresia (HP:0001827)2.67127429
52Vaginal atresia (HP:0000148)2.60015179
53Abnormal blistering of the skin (HP:0008066)2.57859512
54Attenuation of retinal blood vessels (HP:0007843)2.56421629
55Intention tremor (HP:0002080)2.56335239
56Ridged nail (HP:0001807)2.55219286
57Congenital stationary night blindness (HP:0007642)2.55144145
58Anencephaly (HP:0002323)2.54578162
59Advanced eruption of teeth (HP:0006288)2.47624856
60Congenital hepatic fibrosis (HP:0002612)2.43712996
61Furrowed tongue (HP:0000221)2.43215214
62Abnormality of the astrocytes (HP:0100707)2.43066821
63Astrocytoma (HP:0009592)2.43066821
64Natal tooth (HP:0000695)2.41393277
65Sclerocornea (HP:0000647)2.41029793
66Hemiparesis (HP:0001269)2.38376004
67Renal cortical cysts (HP:0000803)2.38161016
68Hyperventilation (HP:0002883)2.36747494
69Hypoglycemic seizures (HP:0002173)2.35146376
70Bifid tongue (HP:0010297)2.34373203
71Ependymoma (HP:0002888)2.32699720
72Conjunctival hamartoma (HP:0100780)2.31297589
73Hypoglycemic coma (HP:0001325)2.30844300
74Tubulointerstitial nephritis (HP:0001970)2.27965797
75Gaze-evoked nystagmus (HP:0000640)2.25807584
76Male pseudohermaphroditism (HP:0000037)2.24996396
77Neck muscle weakness (HP:0000467)2.23601776
78Glioma (HP:0009733)2.23479114
79Pendular nystagmus (HP:0012043)2.22670885
80Renal hypoplasia (HP:0000089)2.22618531
81Postaxial foot polydactyly (HP:0001830)2.22059390
82Thyroiditis (HP:0100646)2.21442121
83Hyperglycinuria (HP:0003108)2.21240657
84Dry hair (HP:0011359)2.18766090
85Occipital encephalocele (HP:0002085)2.18565464
86Abnormal rod and cone electroretinograms (HP:0008323)2.16078182
87Postaxial hand polydactyly (HP:0001162)2.13545801
88Hypohidrosis (HP:0000966)2.13144264
89Abolished electroretinogram (ERG) (HP:0000550)2.12583767
90Palmoplantar keratoderma (HP:0000982)2.10683583
91Pruritus (HP:0000989)2.10561667
92Corneal erosion (HP:0200020)2.08830520
93Ketosis (HP:0001946)2.08558589
94Abnormality of the labia minora (HP:0012880)2.07127805
95Hyperglycinemia (HP:0002154)2.06597631
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05682860
97Abnormality of alanine metabolism (HP:0010916)2.05682860
98Hyperalaninemia (HP:0003348)2.05682860
99Preaxial hand polydactyly (HP:0001177)2.05671262
100Absent speech (HP:0001344)2.05400766
101Poor coordination (HP:0002370)2.04079531
102Ventricular tachycardia (HP:0004756)2.02854974
103Gastrointestinal atresia (HP:0002589)2.02574552
104Narrow forehead (HP:0000341)2.02073926
105Torticollis (HP:0000473)2.01889501
106Hypotrichosis (HP:0001006)12.7446546
107Woolly hair (HP:0002224)11.3433041
108Pili torti (HP:0003777)10.4930965
109Absent eyelashes (HP:0000561)1.99801337
110Progressive macrocephaly (HP:0004481)1.99204709
111Oculomotor apraxia (HP:0000657)1.99151750
112Concave nail (HP:0001598)1.97369509
113Lip pit (HP:0100267)1.95737264
114Neoplasm of the adrenal cortex (HP:0100641)1.94468230
115Calf muscle hypertrophy (HP:0008981)1.93313517
116Abnormality of glycine metabolism (HP:0010895)1.92815956
117Abnormality of serine family amino acid metabolism (HP:0010894)1.92815956
118Bony spicule pigmentary retinopathy (HP:0007737)1.92379260
119Abnormality of molar (HP:0011077)1.91886918
120Abnormality of molar morphology (HP:0011070)1.91886918
121Abnormality of the dental root (HP:0006486)1.91050563
122Taurodontia (HP:0000679)1.91050563
123Abnormality of permanent molar morphology (HP:0011071)1.91050563
124Progressive inability to walk (HP:0002505)1.90970338
125Aqueductal stenosis (HP:0002410)1.90507333
126Abnormality of the parietal bone (HP:0002696)1.87307716
127Type II lissencephaly (HP:0007260)1.87236676
128EEG with generalized epileptiform discharges (HP:0011198)1.82617403
129Aganglionic megacolon (HP:0002251)1.81304670
130Hypsarrhythmia (HP:0002521)1.80189553
131Specific learning disability (HP:0001328)1.79111343
132Methylmalonic acidemia (HP:0002912)1.79040370
133Widely patent fontanelles and sutures (HP:0004492)1.77778789
134Symptomatic seizures (HP:0011145)1.77694496
135Multicystic kidney dysplasia (HP:0000003)1.77389235
136Hypothermia (HP:0002045)1.77135840
137Aplasia/Hypoplasia of the lens (HP:0008063)1.77019441
138Chorioretinal atrophy (HP:0000533)1.76064418
139Increased CSF lactate (HP:0002490)1.74622535
140Prominent nasal bridge (HP:0000426)1.73823773
141Abnormality of the pupil (HP:0000615)1.73381193
142Epileptiform EEG discharges (HP:0011182)1.73051997
143Abnormality of the dental pulp (HP:0006479)1.73040221
144Ventricular fibrillation (HP:0001663)1.72911764
145Colon cancer (HP:0003003)1.72630092
146Mitochondrial inheritance (HP:0001427)1.71261969
147Atrophic scars (HP:0001075)1.70866405
148Decreased testicular size (HP:0008734)1.70339530
149Chorioretinal coloboma (HP:0000567)1.70304486
150Horizontal nystagmus (HP:0000666)1.69674811
151Abnormality of the metopic suture (HP:0005556)1.69541184
152Limb hypertonia (HP:0002509)1.68959248
153Broad foot (HP:0001769)1.68802699
154Retinitis pigmentosa (HP:0000510)1.68628346
155Pigmentary retinal degeneration (HP:0001146)1.68529942
156Hypoplasia of the fovea (HP:0007750)1.68217976
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.68217976
158Neoplasm of the adrenal gland (HP:0100631)1.67884158
159Type 1 muscle fiber predominance (HP:0003803)1.67152457
160Blepharitis (HP:0000498)1.66739116
161Hyporeflexia of lower limbs (HP:0002600)1.65305064
162Abnormality of dental color (HP:0011073)1.65289873
163Recurrent corneal erosions (HP:0000495)1.64915525
164Craniofacial hyperostosis (HP:0004493)1.63735916
165Difficulty walking (HP:0002355)1.63485886
166Craniofacial dystonia (HP:0012179)1.63293652
167Sparse scalp hair (HP:0002209)1.59605625
168Unilateral renal agenesis (HP:0000122)1.58350493
169Amniotic constriction ring (HP:0009775)1.56852580
170Abnormality of placental membranes (HP:0011409)1.56852580
171Acanthosis nigricans (HP:0000956)1.52933903
172Hamartoma of the eye (HP:0010568)1.52680478
173Carious teeth (HP:0000670)1.51873369
174Abnormality of the aortic arch (HP:0012303)1.49027013
175Abnormality of the neuromuscular junction (HP:0003398)1.48485805
176Fatigable weakness (HP:0003473)1.48485805
177Focal dystonia (HP:0004373)1.48313804
178Gangrene (HP:0100758)1.46039619
179Round ear (HP:0100830)1.46014921
180Widely spaced teeth (HP:0000687)1.44205901
181Keratoconjunctivitis sicca (HP:0001097)1.43141159
182Ectropion (HP:0000656)1.41775652
183Anonychia (HP:0001798)1.40125572
184Increased connective tissue (HP:0009025)1.37747269
185Fragile skin (HP:0001030)1.36354094
186Sudden death (HP:0001699)1.36332071
187Abnormality of secondary sexual hair (HP:0009888)1.34361297
188Abnormality of the axillary hair (HP:0100134)1.34361297
189Hypergammaglobulinemia (HP:0010702)1.33830863
190Abnormality of the fingernails (HP:0001231)1.32988937
191Autoamputation (HP:0001218)1.32705567
192Rectal prolapse (HP:0002035)1.31273708
193Laryngomalacia (HP:0001601)1.28189174
194Keratoconjunctivitis (HP:0001096)1.28115014
195Distal lower limb muscle weakness (HP:0009053)1.27742266
196Hypoplastic labia majora (HP:0000059)1.25525797
197Hyperthyroidism (HP:0000836)1.24137082
198Cranial hyperostosis (HP:0004437)1.22059728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.28298938
2MAP4K23.75989378
3LATS13.51960724
4TRIM283.45895859
5EPHA23.41161326
6MAPKAPK33.16612903
7EPHB23.13422063
8TAOK13.03524415
9MAP3K62.95447833
10WNK32.84517880
11FGFR22.77179962
12ERN12.67006219
13MAP3K32.64724615
14MAP3K22.55193992
15MAPK132.41252904
16FGFR12.37043057
17BCR2.31462318
18PIK3CG2.30182752
19TTN2.22514921
20NUAK12.15925011
21MAP3K42.04672274
22TRIB32.04596873
23INSRR2.01975174
24FGFR31.89582503
25MAP3K91.85503465
26CASK1.85099867
27MST1R1.76681466
28RPS6KB21.61838871
29MAP3K111.60022508
30OBSCN1.57753814
31STK391.57468685
32ADRBK21.56790613
33CSNK1G11.54880169
34CDK61.52482186
35CSNK1G31.49649756
36LATS21.49566978
37MAP2K61.49063714
38ZAK1.48815835
39EEF2K1.43357390
40PLK21.42883841
41BCKDK1.42475839
42STK161.38497519
43CSNK1G21.38421443
44SIK11.37665277
45BMPR1B1.36040807
46MARK11.35895025
47MAP2K71.34307858
48MAP3K71.32507369
49EPHB11.26919503
50OXSR11.26601561
51PDGFRA1.24393207
52MUSK1.22775563
53SRPK11.20890022
54PDK21.20812623
55PLK31.20280643
56ACVR1B1.18858515
57WNK41.10493036
58PTK61.09748756
59MAP3K11.07830319
60RPS6KA41.06026423
61DYRK1B1.04017700
62MAP2K41.03110708
63MAPKAPK21.00093906
64BMX0.99979314
65PINK10.99523381
66MKNK20.97950097
67NME10.97810599
68PRKD30.92195851
69PBK0.90881408
70IRAK10.90556129
71PNCK0.89772346
72FRK0.89090003
73TRPM70.88747781
74PTK20.88423190
75NTRK20.87175800
76TXK0.86848931
77PRKCE0.85626034
78DYRK20.81521659
79VRK20.81468791
80FGFR40.80608803
81MAP3K120.80471076
82KSR20.80094099
83BLK0.78842728
84VRK10.78470479
85MET0.76183305
86PKN10.74516236
87RIPK10.73847759
88PLK40.72894532
89MAP2K30.71882622
90PTK2B0.71312075
91NTRK30.67681014
92ERBB40.67629085
93ERBB20.67236217
94LRRK20.64573901
95DDR20.63039852
96MAP2K10.62045259
97PAK30.60869430
98DYRK1A0.60388588
99PRKD10.59493367
100STK380.59405778
101PKN20.58844467
102ERBB30.57918737
103ATM0.54982922
104SIK20.54923307
105TESK10.54525220
106CCNB10.54255388
107NEK10.54085836
108EIF2AK30.54009386
109PHKG10.53236035
110PHKG20.53236035
111CDK190.52474852
112TYRO30.51952019
113MINK10.51817413
114STK30.51778523
115PRKCG0.51700848
116MAP3K50.50984953
117STK110.50509822
118BRSK20.50387016
119AKT30.49884485
120PAK20.48565173
121CSNK1E0.48245414
122PLK10.46446325
123CSNK1A10.45166735
124MKNK10.44654568
125STK38L0.44327683
126ATR0.42429293
127IRAK20.42387681
128ADRBK10.42160209
129PAK60.42081607
130PIK3CA0.42036211
131MAP3K100.41773924
132RET0.41541721
133GSK3A0.41356629
134TNIK0.41264148
135PRKCI0.40892917
136EPHA30.40795594
137GRK10.40446279
138TNK20.39547477
139CDK30.38125289
140PRKAA20.37420952
141RPS6KA10.37265640
142PRKCH0.37206693
143PRKDC0.36365871
144PRKAA10.36201740
145TGFBR20.35700079
146PRKACB0.35502372
147DMPK0.35361248
148CSNK1D0.35218164
149GRK50.35082429
150PRKCZ0.34721157
151FYN0.34717286
152MAPK120.34656088
153SGK10.34272187
154PAK40.33716399
155CSNK1A1L0.33239962
156BRD40.33174965
157CAMK2A0.32683502
158YES10.31708355
159NLK0.31546112
160PIM20.31290584
161ROCK10.30531330
162TIE10.30176563
163PRKACA0.29677918
164JAK10.28465817
165EPHA40.27971928
166STK240.27275560
167CHEK20.26846228
168MST40.26507865
169SRC0.26368014
170MTOR0.25942034

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.48649269
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.47380115
3Fatty acid elongation_Homo sapiens_hsa000623.10786520
4Non-homologous end-joining_Homo sapiens_hsa034503.05279826
5Protein export_Homo sapiens_hsa030603.02944937
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.72715900
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.71548120
8Basal cell carcinoma_Homo sapiens_hsa052172.70125966
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66032706
10Propanoate metabolism_Homo sapiens_hsa006402.54386935
11Caffeine metabolism_Homo sapiens_hsa002322.46193748
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40745496
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20166750
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18654408
15Fat digestion and absorption_Homo sapiens_hsa049752.01303019
16Ether lipid metabolism_Homo sapiens_hsa005651.95589795
17Melanogenesis_Homo sapiens_hsa049161.88047454
18Homologous recombination_Homo sapiens_hsa034401.87785332
19RNA polymerase_Homo sapiens_hsa030201.84981461
20Fanconi anemia pathway_Homo sapiens_hsa034601.82909052
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.77854385
22Oxidative phosphorylation_Homo sapiens_hsa001901.77078250
23Nicotine addiction_Homo sapiens_hsa050331.76781507
24Phenylalanine metabolism_Homo sapiens_hsa003601.76110552
25Hippo signaling pathway_Homo sapiens_hsa043901.73692497
26Hedgehog signaling pathway_Homo sapiens_hsa043401.73660075
27Axon guidance_Homo sapiens_hsa043601.67337951
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65190626
29Glioma_Homo sapiens_hsa052141.56271480
30VEGF signaling pathway_Homo sapiens_hsa043701.53897584
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50737713
32Dorso-ventral axis formation_Homo sapiens_hsa043201.48240609
33Adherens junction_Homo sapiens_hsa045201.47979280
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47715132
35Tight junction_Homo sapiens_hsa045301.45144286
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42491443
37Proteoglycans in cancer_Homo sapiens_hsa052051.42002630
38Bladder cancer_Homo sapiens_hsa052191.39999577
39Tryptophan metabolism_Homo sapiens_hsa003801.36460043
40Basal transcription factors_Homo sapiens_hsa030221.34437954
41GnRH signaling pathway_Homo sapiens_hsa049121.31849170
42One carbon pool by folate_Homo sapiens_hsa006701.30812466
43Proteasome_Homo sapiens_hsa030501.30500925
44Parkinsons disease_Homo sapiens_hsa050121.29944767
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.29549550
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.29521309
47Mineral absorption_Homo sapiens_hsa049781.28689722
48ECM-receptor interaction_Homo sapiens_hsa045121.28426457
49Long-term potentiation_Homo sapiens_hsa047201.26877338
50Thyroid cancer_Homo sapiens_hsa052161.26508908
51Collecting duct acid secretion_Homo sapiens_hsa049661.26493000
52Arachidonic acid metabolism_Homo sapiens_hsa005901.26324234
53Taste transduction_Homo sapiens_hsa047421.25405881
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23500128
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22696971
56Phototransduction_Homo sapiens_hsa047441.21570487
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20790814
58Histidine metabolism_Homo sapiens_hsa003401.20377534
59Wnt signaling pathway_Homo sapiens_hsa043101.19654947
60Peroxisome_Homo sapiens_hsa041461.17648886
61Acute myeloid leukemia_Homo sapiens_hsa052211.10479049
62Endometrial cancer_Homo sapiens_hsa052131.09271246
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08160988
64Steroid biosynthesis_Homo sapiens_hsa001001.07349557
65TGF-beta signaling pathway_Homo sapiens_hsa043501.06925495
66Selenocompound metabolism_Homo sapiens_hsa004501.05975300
67Fatty acid degradation_Homo sapiens_hsa000711.03653371
68Circadian rhythm_Homo sapiens_hsa047101.03525385
69Tyrosine metabolism_Homo sapiens_hsa003501.01874397
70Regulation of autophagy_Homo sapiens_hsa041401.00252489
71Long-term depression_Homo sapiens_hsa047301.00137248
72Insulin secretion_Homo sapiens_hsa049110.99843524
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.99347742
74MicroRNAs in cancer_Homo sapiens_hsa052060.94833627
75Non-small cell lung cancer_Homo sapiens_hsa052230.94694804
76Pancreatic secretion_Homo sapiens_hsa049720.92874866
77Amoebiasis_Homo sapiens_hsa051460.91181662
78Base excision repair_Homo sapiens_hsa034100.90910442
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90879143
80Huntingtons disease_Homo sapiens_hsa050160.90126689
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.90005251
82Gastric acid secretion_Homo sapiens_hsa049710.87926819
83Renin secretion_Homo sapiens_hsa049240.87789085
84GABAergic synapse_Homo sapiens_hsa047270.87365854
85Estrogen signaling pathway_Homo sapiens_hsa049150.86389039
86Ras signaling pathway_Homo sapiens_hsa040140.86065993
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.85651859
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84837308
89Protein digestion and absorption_Homo sapiens_hsa049740.84131213
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83299908
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83076328
92Focal adhesion_Homo sapiens_hsa045100.82137021
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81263764
94RNA degradation_Homo sapiens_hsa030180.81165471
95PPAR signaling pathway_Homo sapiens_hsa033200.80986690
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78531533
97Vitamin B6 metabolism_Homo sapiens_hsa007500.78461435
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78168123
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77648232
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76869314
101ABC transporters_Homo sapiens_hsa020100.76853526
102Retinol metabolism_Homo sapiens_hsa008300.76536990
103Sulfur metabolism_Homo sapiens_hsa009200.75722068
104Oxytocin signaling pathway_Homo sapiens_hsa049210.75250998
105Metabolic pathways_Homo sapiens_hsa011000.75026172
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74817804
107Folate biosynthesis_Homo sapiens_hsa007900.74728620
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74246348
109Sphingolipid metabolism_Homo sapiens_hsa006000.73612331
110Pyruvate metabolism_Homo sapiens_hsa006200.71835305
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71605402
112p53 signaling pathway_Homo sapiens_hsa041150.71286036
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.70934229
114Alzheimers disease_Homo sapiens_hsa050100.70174323
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69788357
116Purine metabolism_Homo sapiens_hsa002300.69669384
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69530898
118Pertussis_Homo sapiens_hsa051330.69437877
119Rap1 signaling pathway_Homo sapiens_hsa040150.69081575
120Melanoma_Homo sapiens_hsa052180.69000382
121Morphine addiction_Homo sapiens_hsa050320.67721608
122Insulin resistance_Homo sapiens_hsa049310.66998620
123Glutamatergic synapse_Homo sapiens_hsa047240.66013663
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64888304
125Circadian entrainment_Homo sapiens_hsa047130.64077424
126RNA transport_Homo sapiens_hsa030130.63619158
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62575003
128Platelet activation_Homo sapiens_hsa046110.62123029
129Mismatch repair_Homo sapiens_hsa034300.60779719
130beta-Alanine metabolism_Homo sapiens_hsa004100.60736951
131Butanoate metabolism_Homo sapiens_hsa006500.60565128
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59623592
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59522094
134Hepatitis C_Homo sapiens_hsa051600.58923718
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57716691
136Glutathione metabolism_Homo sapiens_hsa004800.57468918
137ErbB signaling pathway_Homo sapiens_hsa040120.57466974
138Salivary secretion_Homo sapiens_hsa049700.56501885
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.56184180
140Serotonergic synapse_Homo sapiens_hsa047260.55225213
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54554737
142Glycerolipid metabolism_Homo sapiens_hsa005610.53897077
143Nucleotide excision repair_Homo sapiens_hsa034200.53501726
144Renal cell carcinoma_Homo sapiens_hsa052110.52528142
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52047591
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51594794
147Gap junction_Homo sapiens_hsa045400.51515641
148Insulin signaling pathway_Homo sapiens_hsa049100.50680010
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50346351
150Prostate cancer_Homo sapiens_hsa052150.49468283
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.49387340
152Dilated cardiomyopathy_Homo sapiens_hsa054140.48590315
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48563270
154Pathways in cancer_Homo sapiens_hsa052000.48375656
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47804806
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.47355031
157Dopaminergic synapse_Homo sapiens_hsa047280.47093956
158Chronic myeloid leukemia_Homo sapiens_hsa052200.46988373
159Cardiac muscle contraction_Homo sapiens_hsa042600.46958614
160Pyrimidine metabolism_Homo sapiens_hsa002400.46398302
161Staphylococcus aureus infection_Homo sapiens_hsa051500.46269614
162Nitrogen metabolism_Homo sapiens_hsa009100.43663339
163Olfactory transduction_Homo sapiens_hsa047400.43448431
164Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43065312
165Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42130765
166Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41930335
167Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41535422
168Fatty acid metabolism_Homo sapiens_hsa012120.41301140
169Pancreatic cancer_Homo sapiens_hsa052120.41080429
170Fatty acid biosynthesis_Homo sapiens_hsa000610.40380368
171Oocyte meiosis_Homo sapiens_hsa041140.39911384
172MAPK signaling pathway_Homo sapiens_hsa040100.39853708
173Chemical carcinogenesis_Homo sapiens_hsa052040.39767094
174Amphetamine addiction_Homo sapiens_hsa050310.39345997
175Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39205642
176Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38995319
177Notch signaling pathway_Homo sapiens_hsa043300.37354296
178Cocaine addiction_Homo sapiens_hsa050300.37343088
179SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36033250

Most similar genes based on co-expression Upload to Enrichr

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