LYL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.39705613
2viral transcription (GO:0019083)5.77429660
3translational termination (GO:0006415)5.50821733
4neutrophil activation involved in immune response (GO:0002283)5.34983969
5DNA deamination (GO:0045006)4.96548574
6translational elongation (GO:0006414)4.89552628
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.87945947
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.87945947
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.76922089
10ribosomal small subunit biogenesis (GO:0042274)4.72004508
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65028133
12cotranslational protein targeting to membrane (GO:0006613)4.65014479
13protein targeting to ER (GO:0045047)4.63468452
14antigen processing and presentation via MHC class Ib (GO:0002475)4.46962778
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44652798
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.44652798
17modulation by symbiont of host immune response (GO:0052553)4.44652798
18positive regulation by symbiont of host defense response (GO:0052509)4.44652798
19modulation by symbiont of host defense response (GO:0052031)4.44652798
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44652798
21positive regulation of B cell differentiation (GO:0045579)4.42476062
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42036927
23protein localization to endoplasmic reticulum (GO:0070972)4.39543282
24maturation of SSU-rRNA (GO:0030490)4.36709782
25regulation of mast cell degranulation (GO:0043304)4.31071350
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28839319
27antigen processing and presentation of endogenous antigen (GO:0019883)4.27868947
28viral life cycle (GO:0019058)4.22075872
29negative regulation of cell killing (GO:0031342)4.19342243
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19342243
31cellular protein complex disassembly (GO:0043624)4.14158218
32oxygen transport (GO:0015671)4.03230014
33regulation of mast cell activation involved in immune response (GO:0033006)4.01593502
34telomere maintenance via semi-conservative replication (GO:0032201)3.95892534
35translational initiation (GO:0006413)3.89502415
36negative regulation of erythrocyte differentiation (GO:0045647)3.88836316
37response to interferon-beta (GO:0035456)3.86654604
38regulation of gamma-delta T cell activation (GO:0046643)3.84640952
39platelet dense granule organization (GO:0060155)3.81943321
40negative regulation of phagocytosis (GO:0050765)3.81321669
41detection of bacterium (GO:0016045)3.79583162
42DNA strand elongation involved in DNA replication (GO:0006271)3.79433422
43detection of other organism (GO:0098543)3.77369557
44megakaryocyte development (GO:0035855)3.77354505
45protein complex disassembly (GO:0043241)3.77243445
46regulation of myeloid leukocyte mediated immunity (GO:0002886)3.74570873
47neutrophil activation (GO:0042119)3.72052973
48protoporphyrinogen IX metabolic process (GO:0046501)3.69739081
49DNA strand elongation (GO:0022616)3.68095204
50positive regulation of gamma-delta T cell activation (GO:0046645)3.59442712
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.59046724
52* definitive hemopoiesis (GO:0060216)3.57324948
53regulation of mast cell activation (GO:0033003)3.56423341
54cellular extravasation (GO:0045123)3.53888407
55macromolecular complex disassembly (GO:0032984)3.51079801
56mature B cell differentiation involved in immune response (GO:0002313)3.48600288
57regulation of leukocyte degranulation (GO:0043300)3.48476826
58regulation of B cell differentiation (GO:0045577)3.48236837
59negative regulation of interleukin-12 production (GO:0032695)3.47533086
60defense response to protozoan (GO:0042832)3.46321796
61leukocyte aggregation (GO:0070486)3.44374587
62lymphoid progenitor cell differentiation (GO:0002320)3.37902799
63positive regulation of mast cell activation (GO:0033005)3.37493582
64telomere maintenance via recombination (GO:0000722)3.37171723
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.35950967
66response to host immune response (GO:0052572)3.35950967
67granulocyte activation (GO:0036230)3.34127863
68leukocyte degranulation (GO:0043299)3.32940149
69protoporphyrinogen IX biosynthetic process (GO:0006782)3.29949683
70immunoglobulin mediated immune response (GO:0016064)3.29567293
71nuclear-transcribed mRNA catabolic process (GO:0000956)3.28755111
72respiratory burst (GO:0045730)3.28425420
73response to protozoan (GO:0001562)3.24541498
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23994963
75gas transport (GO:0015669)3.23632586
76DNA unwinding involved in DNA replication (GO:0006268)3.23350701
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22195859
78macrophage activation involved in immune response (GO:0002281)3.21987067
79B cell receptor signaling pathway (GO:0050853)3.21217166
80positive regulation of mast cell activation involved in immune response (GO:0033008)3.20461729
81positive regulation of mast cell degranulation (GO:0043306)3.20461729
82myeloid cell activation involved in immune response (GO:0002275)3.18867968
83DNA replication initiation (GO:0006270)3.18106123
84mRNA catabolic process (GO:0006402)3.15675675
85endosome to pigment granule transport (GO:0043485)3.14505423
86endosome to melanosome transport (GO:0035646)3.14505423
87negative regulation of lymphocyte mediated immunity (GO:0002707)3.13585704
88microglial cell activation (GO:0001774)3.08867055
89germinal center formation (GO:0002467)3.07347220
90purine-containing compound salvage (GO:0043101)3.07283247
91hemoglobin metabolic process (GO:0020027)3.05019505
92regulation of B cell receptor signaling pathway (GO:0050855)3.04797153
93positive thymic T cell selection (GO:0045059)3.04728559
94protein targeting to membrane (GO:0006612)3.03061408
95regulation of erythrocyte differentiation (GO:0045646)3.02749822
96mature B cell differentiation (GO:0002335)3.02038365
97RNA catabolic process (GO:0006401)3.01906476
98regulation of platelet aggregation (GO:0090330)3.00977801
99heme biosynthetic process (GO:0006783)3.00362518
100neutrophil mediated immunity (GO:0002446)2.99354580
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98738161
102secretory granule organization (GO:0033363)2.98524304
103Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98336037
104negative regulation of T cell mediated immunity (GO:0002710)2.98150037
105mitotic recombination (GO:0006312)2.98107880
106positive regulation of megakaryocyte differentiation (GO:0045654)2.96295319
107positive regulation of granulocyte differentiation (GO:0030854)2.94161821
108mast cell activation (GO:0045576)2.93876538
109response to interferon-alpha (GO:0035455)2.93769994
110T cell homeostasis (GO:0043029)2.93710986
111response to interleukin-15 (GO:0070672)2.92611329
112negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92477418
113response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92300768
114response to host (GO:0075136)2.92300768
115response to host defenses (GO:0052200)2.92300768
116detection of external biotic stimulus (GO:0098581)2.92286433
117erythrocyte maturation (GO:0043249)2.91641853
118erythrocyte development (GO:0048821)2.90550443
119regulation of regulated secretory pathway (GO:1903305)2.89619890
120negative regulation of leukocyte mediated immunity (GO:0002704)2.87477394
121angiogenesis involved in wound healing (GO:0060055)2.84798040
122negative regulation of interleukin-6 production (GO:0032715)2.83960431
123telomere maintenance via telomere lengthening (GO:0010833)2.81381420
124response to muramyl dipeptide (GO:0032495)2.78910603
125negative thymic T cell selection (GO:0045060)2.78620233
126ribosomal large subunit biogenesis (GO:0042273)2.78507471
127embryonic hemopoiesis (GO:0035162)2.78496229
128regulation of B cell apoptotic process (GO:0002902)2.78059621
129lymph node development (GO:0048535)2.76112744
130cellular response to interferon-beta (GO:0035458)2.76108761
131regulation of antigen processing and presentation (GO:0002577)2.75931626
132regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72921947
133cellular response to thyroid hormone stimulus (GO:0097067)2.71712606
134granulocyte differentiation (GO:0030851)2.71673179
135B cell mediated immunity (GO:0019724)2.71638366
136leukocyte migration involved in inflammatory response (GO:0002523)2.71315510
137porphyrin-containing compound biosynthetic process (GO:0006779)2.70874876
138positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.69949111
139macrophage activation (GO:0042116)2.69940091
140translation (GO:0006412)2.68887018
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67556578
142macrophage differentiation (GO:0030225)2.67004868
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65257271
144positive regulation of antigen processing and presentation (GO:0002579)2.65111947
145negative regulation of granulocyte differentiation (GO:0030853)2.64017753
146nucleotide-excision repair, DNA gap filling (GO:0006297)2.61924672
147ribonucleoprotein complex biogenesis (GO:0022613)2.61637955
148mast cell activation involved in immune response (GO:0002279)2.61143129
149mast cell degranulation (GO:0043303)2.61143129
150IMP metabolic process (GO:0046040)2.60463905
151translesion synthesis (GO:0019985)2.60202497
152negative regulation of RNA splicing (GO:0033119)2.59014987
153regulation of gamma-delta T cell differentiation (GO:0045586)2.58816226
154regulation of granulocyte differentiation (GO:0030852)2.57794810
155Peyers patch development (GO:0048541)2.55141854
156mucosal-associated lymphoid tissue development (GO:0048537)2.55141854
157leukocyte homeostasis (GO:0001776)2.55028106
158regulation of interferon-beta biosynthetic process (GO:0045357)2.53909691
1593-UTR-mediated mRNA stabilization (GO:0070935)2.51575553
160pseudouridine synthesis (GO:0001522)2.51105583
161myeloid dendritic cell activation (GO:0001773)2.51009175
162cellular response to zinc ion (GO:0071294)2.48935159
163pentose-phosphate shunt (GO:0006098)2.48924117
164ncRNA 3-end processing (GO:0043628)2.48147798
165tRNA methylation (GO:0030488)2.47255595
166formation of translation preinitiation complex (GO:0001731)2.44358597
167response to peptidoglycan (GO:0032494)2.43716240
168lymphocyte homeostasis (GO:0002260)2.43654781
169myeloid cell development (GO:0061515)2.43530626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85201464
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65939923
3* SCL_19346495_ChIP-Seq_HPC-7_Human3.63216878
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04800993
5* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.92028090
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.89338297
7* MYC_22102868_ChIP-Seq_BL_Human2.82427529
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.81818682
9* VDR_21846776_ChIP-Seq_THP-1_Human2.80360488
10* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.68700487
11* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.62555723
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61568337
13* GATA1_19941826_ChIP-Seq_K562_Human2.60869794
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56960637
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56856405
16* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54744386
17* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.49487431
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37894781
19GATA1_22025678_ChIP-Seq_K562_Human2.19940251
20* SPI1_23547873_ChIP-Seq_NB4_Human2.14951242
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14484927
22* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.06015096
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02057500
24* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.00954674
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.98368360
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93449693
27* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92516144
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90144511
29* VDR_24763502_ChIP-Seq_THP-1_Human1.89829030
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87344835
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.84429912
32VDR_23849224_ChIP-Seq_CD4+_Human1.81737017
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.81519717
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.80972924
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.80670124
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79455340
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.79428808
38CIITA_25753668_ChIP-Seq_RAJI_Human1.77695813
39* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77588226
40* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.76892192
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.75764263
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.74742539
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74393391
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71671433
45FOXP3_21729870_ChIP-Seq_TREG_Human1.70450244
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69849060
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.69684621
48* GATA2_19941826_ChIP-Seq_K562_Human1.68573785
49* MAF_26560356_Chip-Seq_TH1_Human1.68491140
50* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68206726
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68029777
52XRN2_22483619_ChIP-Seq_HELA_Human1.67302905
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65294113
54* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64260599
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63305795
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61231860
57* MYB_26560356_Chip-Seq_TH2_Human1.60324312
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60219306
59* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.59393443
60BCL6_27268052_Chip-Seq_Bcells_Human1.59233619
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57030757
62* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56599891
63* NCOR1_26117541_ChIP-Seq_K562_Human1.54522140
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.51891880
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51312833
66* UTX_26944678_Chip-Seq_JUKART_Human1.51264077
67* ELF1_20517297_ChIP-Seq_JURKAT_Human1.50864754
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49503920
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49380509
70GATA3_27048872_Chip-Seq_THYMUS_Human1.49051177
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.47731372
72* MYB_26560356_Chip-Seq_TH1_Human1.47648941
73* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46980555
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45387884
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44059183
76* KDM2B_26808549_Chip-Seq_DND41_Human1.42976209
77BCOR_27268052_Chip-Seq_Bcells_Human1.40109957
78* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37386277
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.35972806
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34617292
81* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33713925
82GABP_19822575_ChIP-Seq_HepG2_Human1.31534831
83* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31489966
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30542764
85* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30277137
86* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29292258
87DCP1A_22483619_ChIP-Seq_HELA_Human1.27375526
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26644639
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.26078552
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25928859
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24757047
92TTF2_22483619_ChIP-Seq_HELA_Human1.23843049
93SPI1_23127762_ChIP-Seq_K562_Human1.19875878
94* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19872692
95LXR_22292898_ChIP-Seq_THP-1_Human1.19568392
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18832569
97* MAF_26560356_Chip-Seq_TH2_Human1.18363352
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18315818
99* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18117238
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17765537
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17645688
102SPI1_20517297_ChIP-Seq_HL60_Human1.17124113
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16520463
104* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16009849
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14790803
106GATA3_26560356_Chip-Seq_TH2_Human1.14511627
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12955079
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12489923
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11149256
110P300_27268052_Chip-Seq_Bcells_Human1.10733330
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10095287
112VDR_24787735_ChIP-Seq_THP-1_Human1.09883226
113* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09711757
114P68_20966046_ChIP-Seq_HELA_Human1.09365020
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08627776
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04588061
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04321480
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04116747
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03760496
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.03130850
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02543785
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01142848
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00010907
124* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99608883
125* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99436868
126* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98734346
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98682656
128CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98110154
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97598299
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97079287
131ELK1_19687146_ChIP-ChIP_HELA_Human0.96860656
132RUNX_20019798_ChIP-Seq_JUKART_Human0.96180267
133E2F1_20622854_ChIP-Seq_HELA_Human0.96168349
134KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95709774
135* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95003518
136ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92364230
137CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91402059
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90941045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.30467916
2MP0001835_abnormal_antigen_presentation3.63962230
3MP0000685_abnormal_immune_system3.00717136
4MP0004808_abnormal_hematopoietic_stem2.97348109
5MP0001545_abnormal_hematopoietic_system2.80960426
6MP0005397_hematopoietic_system_phenotyp2.80960426
7MP0005464_abnormal_platelet_physiology2.76851037
8MP0005174_abnormal_tail_pigmentation2.74461752
9MP0005671_abnormal_response_to2.62305433
10MP0009785_altered_susceptibility_to2.58149890
11MP0001800_abnormal_humoral_immune2.55773574
12* MP0002398_abnormal_bone_marrow2.48023446
13MP0000465_gastrointestinal_hemorrhage2.41109241
14MP0005025_abnormal_response_to2.38272512
15MP0002452_abnormal_antigen_presenting2.34218941
16MP0003436_decreased_susceptibility_to2.32136644
17MP0002420_abnormal_adaptive_immunity2.26405646
18MP0004147_increased_porphyrin_level2.26232830
19MP0000689_abnormal_spleen_morphology2.24921326
20MP0003656_abnormal_erythrocyte_physiolo2.23233462
21MP0001819_abnormal_immune_cell2.22788356
22MP0002723_abnormal_immune_serum2.21297936
23MP0000490_abnormal_crypts_of2.18698319
24MP0005000_abnormal_immune_tolerance2.16414640
25MP0002419_abnormal_innate_immunity2.15978587
26MP0005075_abnormal_melanosome_morpholog2.14532850
27MP0001873_stomach_inflammation2.12789792
28MP0003693_abnormal_embryo_hatching2.12128403
29MP0002722_abnormal_immune_system2.09828248
30MP0010094_abnormal_chromosome_stability2.07518815
31MP0003763_abnormal_thymus_physiology2.07044163
32* MP0000716_abnormal_immune_system2.06668030
33* MP0002429_abnormal_blood_cell1.96726988
34MP0001790_abnormal_immune_system1.93947529
35MP0005387_immune_system_phenotype1.93947529
36MP0002148_abnormal_hypersensitivity_rea1.87276268
37MP0009333_abnormal_splenocyte_physiolog1.81600053
38MP0009278_abnormal_bone_marrow1.80198883
39MP0003806_abnormal_nucleotide_metabolis1.79087668
40MP0002166_altered_tumor_susceptibility1.78706651
41MP0002095_abnormal_skin_pigmentation1.78440608
42MP0003077_abnormal_cell_cycle1.67658576
43MP0002405_respiratory_system_inflammati1.64956657
44MP0003724_increased_susceptibility_to1.64272783
45MP0008058_abnormal_DNA_repair1.64169551
46MP0001853_heart_inflammation1.63847303
47MP0005083_abnormal_biliary_tract1.62330884
48MP0010155_abnormal_intestine_physiology1.61944401
49MP0003303_peritoneal_inflammation1.60252412
50MP0003866_abnormal_defecation1.58602767
51MP0003172_abnormal_lysosome_physiology1.57956971
52MP0000703_abnormal_thymus_morphology1.56710672
53MP0008007_abnormal_cellular_replicative1.55762457
54MP0009379_abnormal_foot_pigmentation1.52466813
55MP0003111_abnormal_nucleus_morphology1.46413851
56MP0001845_abnormal_inflammatory_respons1.43724939
57MP0008057_abnormal_DNA_replication1.42536425
58MP0001986_abnormal_taste_sensitivity1.42024257
59MP0002019_abnormal_tumor_incidence1.36927337
60MP0000015_abnormal_ear_pigmentation1.35682613
61MP0004957_abnormal_blastocyst_morpholog1.32400736
62MP0003191_abnormal_cellular_cholesterol1.28660521
63MP0005058_abnormal_lysosome_morphology1.28563934
64MP0006054_spinal_hemorrhage1.25185016
65MP0002006_tumorigenesis1.24425493
66MP0008469_abnormal_protein_level1.23360011
67MP0008260_abnormal_autophagy1.18886612
68MP0010307_abnormal_tumor_latency1.15967666
69MP0005451_abnormal_body_composition1.13103175
70MP0003300_gastrointestinal_ulcer1.08965677
71MP0004510_myositis1.08673017
72MP0008004_abnormal_stomach_pH1.08522733
73MP0000313_abnormal_cell_death1.07976614
74MP0001533_abnormal_skeleton_physiology1.06380757
75MP0004947_skin_inflammation0.97846320
76MP0005084_abnormal_gallbladder_morpholo0.96691946
77MP0003943_abnormal_hepatobiliary_system0.96382219
78MP0001663_abnormal_digestive_system0.96131804
79MP0006082_CNS_inflammation0.96118416
80MP0002933_joint_inflammation0.95091878
81MP0000343_altered_response_to0.92760736
82MP0009765_abnormal_xenobiotic_induced0.91514473
83MP0002132_abnormal_respiratory_system0.91002419
84MP0008995_early_reproductive_senescence0.89426240
85MP0003786_premature_aging0.86007032
86MP0006036_abnormal_mitochondrial_physio0.84202750
87MP0001851_eye_inflammation0.77671259
88MP0000858_altered_metastatic_potential0.75765774
89MP0005167_abnormal_blood-brain_barrier0.72041910
90MP0005636_abnormal_mineral_homeostasis0.71218931
91MP0003075_altered_response_to0.69523001
92MP0009763_increased_sensitivity_to0.68016041
93MP0000598_abnormal_liver_morphology0.67479911
94MP0003183_abnormal_peptide_metabolism0.65825242
95MP0003186_abnormal_redox_activity0.65703666
96MP0000350_abnormal_cell_proliferation0.64931532
97MP0005535_abnormal_body_temperature0.64591063
98MP0009840_abnormal_foam_cell0.64543798
99MP0005310_abnormal_salivary_gland0.64087106
100MP0000477_abnormal_intestine_morphology0.63335828
101MP0002075_abnormal_coat/hair_pigmentati0.63227688
102MP0002138_abnormal_hepatobiliary_system0.63126747
103MP0002998_abnormal_bone_remodeling0.62522391
104MP0005319_abnormal_enzyme/_coenzyme0.62416118
105MP0000609_abnormal_liver_physiology0.61829527
106MP0003828_pulmonary_edema0.61593490
107MP0006292_abnormal_olfactory_placode0.60850588
108MP0008873_increased_physiological_sensi0.59390803
109MP0009764_decreased_sensitivity_to0.58602025
110MP0005166_decreased_susceptibility_to0.58334717
111MP0003638_abnormal_response/metabolism_0.58020012
112MP0001764_abnormal_homeostasis0.57935037
113MP0006035_abnormal_mitochondrial_morpho0.57664738
114MP0003795_abnormal_bone_structure0.57246761
115MP0000371_diluted_coat_color0.56245081
116MP0004381_abnormal_hair_follicle0.55596009
117MP0005645_abnormal_hypothalamus_physiol0.55414308
118MP0002653_abnormal_ependyma_morphology0.54206698
119MP0008874_decreased_physiological_sensi0.54061728
120MP0003567_abnormal_fetal_cardiomyocyte0.53454104
121MP0005390_skeleton_phenotype0.51519983
122MP0004883_abnormal_blood_vessel0.50323464
123MP0009931_abnormal_skin_appearance0.49098556

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.53033817
2Abnormal number of erythroid precursors (HP:0012131)5.50552205
3Thrombocytosis (HP:0001894)5.50419269
4Hypochromic microcytic anemia (HP:0004840)5.05284136
5IgM deficiency (HP:0002850)4.95506198
6Stomatitis (HP:0010280)4.84214745
7Reticulocytopenia (HP:0001896)4.58369903
8Aplastic anemia (HP:0001915)4.33301467
9Chronic otitis media (HP:0000389)4.25312637
10Prolonged bleeding time (HP:0003010)4.14716273
11Petechiae (HP:0000967)4.02037292
12Recurrent abscess formation (HP:0002722)3.93981924
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.91794619
14Hypochromic anemia (HP:0001931)3.86900747
15Elevated erythrocyte sedimentation rate (HP:0003565)3.80627999
16Cellulitis (HP:0100658)3.70760921
17Recurrent bacterial skin infections (HP:0005406)3.59019431
18Myositis (HP:0100614)3.40801368
19Pallor (HP:0000980)3.32520376
20Orchitis (HP:0100796)3.30575015
21Recurrent bronchitis (HP:0002837)3.24740788
22Epistaxis (HP:0000421)3.22271642
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.22202526
24Recurrent gram-negative bacterial infections (HP:0005420)3.20440709
25Polycythemia (HP:0001901)3.17848900
26Agammaglobulinemia (HP:0004432)3.17647136
27Panhypogammaglobulinemia (HP:0003139)3.15741965
28Recurrent viral infections (HP:0004429)3.12866896
29Impaired platelet aggregation (HP:0003540)3.12796979
30Abnormal platelet function (HP:0011869)3.12796979
31Abnormality of T cell physiology (HP:0011840)3.11559343
32Abnormality of iron homeostasis (HP:0011031)3.10384026
33Meningitis (HP:0001287)3.10248758
34Urticaria (HP:0001025)3.08816739
35Encephalitis (HP:0002383)3.06733129
36Poikiloderma (HP:0001029)3.05362493
37Abnormal platelet volume (HP:0011876)3.04947089
38Reduced antithrombin III activity (HP:0001976)3.03917582
39Gastrointestinal infarctions (HP:0005244)2.97920695
40Episodic fever (HP:0001954)2.94990780
41Gastrointestinal inflammation (HP:0004386)2.94182425
42Macrocytic anemia (HP:0001972)2.91027055
43Eczematoid dermatitis (HP:0000976)2.90910845
44Increased serum ferritin (HP:0003281)2.89951829
45Inflammation of the large intestine (HP:0002037)2.88546196
46Leukocytosis (HP:0001974)2.78936057
47Abnormality of transition element cation homeostasis (HP:0011030)2.78333024
48Retrobulbar optic neuritis (HP:0100654)2.77288840
49Optic neuritis (HP:0100653)2.77288840
50Recurrent fungal infections (HP:0002841)2.75546483
51Granulocytopenia (HP:0001913)2.75195509
52Interstitial pulmonary disease (HP:0006530)2.74210500
53Hypertensive crisis (HP:0100735)2.73972770
54Type I transferrin isoform profile (HP:0003642)2.69957652
55Colitis (HP:0002583)2.69568113
56Recurrent skin infections (HP:0001581)2.67656599
57Abnormality of the nasal mucosa (HP:0000433)2.66728932
58B lymphocytopenia (HP:0010976)2.66537070
59Abnormality of B cell number (HP:0010975)2.66537070
60Abnormal hemoglobin (HP:0011902)2.66332139
61Pustule (HP:0200039)2.65957319
62Hepatosplenomegaly (HP:0001433)2.65413281
63Myelodysplasia (HP:0002863)2.60609918
64Reticulocytosis (HP:0001923)2.58428503
65Nasal polyposis (HP:0100582)2.56602481
66Acute lymphatic leukemia (HP:0006721)2.54173781
67Spontaneous hematomas (HP:0007420)2.46992178
68Lymphopenia (HP:0001888)2.44401220
69Gastrointestinal stroma tumor (HP:0100723)2.43428163
70Obstructive lung disease (HP:0006536)2.40324670
71Chronic obstructive pulmonary disease (HP:0006510)2.40324670
72Muscle fiber atrophy (HP:0100295)2.40033281
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.37241607
74Increased mean platelet volume (HP:0011877)2.36864064
75Gingivitis (HP:0000230)2.35748367
76Acute myeloid leukemia (HP:0004808)2.35646899
77Entropion (HP:0000621)2.34979778
78Lymphoma (HP:0002665)2.34302077
79Abnormality of macrophages (HP:0004311)2.32594579
80Abnormality of T cells (HP:0002843)2.30002021
81Menorrhagia (HP:0000132)2.26867201
82Abnormality of DNA repair (HP:0003254)2.25458168
83Microcytic anemia (HP:0001935)2.24274957
84Type 2 muscle fiber atrophy (HP:0003554)2.22816833
85Aplasia/Hypoplasia of the thymus (HP:0010515)2.22480163
86Arterial thrombosis (HP:0004420)2.21242279
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20945522
88Abnormal protein N-linked glycosylation (HP:0012347)2.20945522
89Abnormal protein glycosylation (HP:0012346)2.20945522
90Abnormal glycosylation (HP:0012345)2.20945522
91Neutropenia (HP:0001875)2.20332803
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.20165233
93Chronic mucocutaneous candidiasis (HP:0002728)2.19792493
94Recurrent cutaneous fungal infections (HP:0011370)2.19792493
95Abnormality of reticulocytes (HP:0004312)2.19655973
96Osteomyelitis (HP:0002754)2.19648037
97Amaurosis fugax (HP:0100576)2.18968375
98Thoracic kyphosis (HP:0002942)2.18593326
99Pulmonary infiltrates (HP:0002113)2.18460866
100Hemoptysis (HP:0002105)2.17800416
101Increased IgM level (HP:0003496)2.16859181
102Abnormality of the prostate (HP:0008775)2.16550415
103Mediastinal lymphadenopathy (HP:0100721)2.15722582
104Chest pain (HP:0100749)2.15547243
105Vacuolated lymphocytes (HP:0001922)2.14878106
106Abnormality of the thoracic spine (HP:0100711)2.13799475
107Vasculitis (HP:0002633)2.12948080
108Gingival bleeding (HP:0000225)2.12265401
109Pancytopenia (HP:0001876)2.12031578
110Albinism (HP:0001022)2.11896297
111Thyroiditis (HP:0100646)2.10282006
112Chronic sinusitis (HP:0011109)2.09027226
113Keratoconjunctivitis sicca (HP:0001097)2.08238523
114IgG deficiency (HP:0004315)2.07289651
115Hematochezia (HP:0002573)2.07001110
116Purpura (HP:0000979)2.06915558
117Anorexia (HP:0002039)2.04258762
118Pulmonary embolism (HP:0002204)2.02262935
119Sepsis (HP:0100806)2.01623408
120Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00916131
121Keratoconjunctivitis (HP:0001096)2.00547841
122Acanthocytosis (HP:0001927)1.97659466
123Increased cerebral lipofuscin (HP:0011813)1.97218642
124Increased IgE level (HP:0003212)1.96732121
125Abnormal rod and cone electroretinograms (HP:0008323)1.95993731
126Abnormality of glycolipid metabolism (HP:0010969)1.95618897
127Abnormality of liposaccharide metabolism (HP:0010968)1.95618897
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.95618897
129Erythema (HP:0010783)1.95145681
130Abnormality of the columella (HP:0009929)1.94099837
131Poikilocytosis (HP:0004447)1.91133108
132Hypoplasia of the thymus (HP:0000778)1.90042019
133Papilloma (HP:0012740)1.89636876
134Verrucae (HP:0200043)1.89636876
135Hypergammaglobulinemia (HP:0010702)1.89496308
136Splenomegaly (HP:0001744)1.89410147
137Severe visual impairment (HP:0001141)1.89317567
138Recurrent sinusitis (HP:0011108)1.88757378
139Autoimmune thrombocytopenia (HP:0001973)1.87779358
140Cutaneous photosensitivity (HP:0000992)1.87662544
14111 pairs of ribs (HP:0000878)1.87151980
142Leukopenia (HP:0001882)1.86471437
143Fatigue (HP:0012378)1.86262088
144Recurrent lower respiratory tract infections (HP:0002783)1.86159472
145Skin rash (HP:0000988)1.86147675
146Agnosia (HP:0010524)1.85400526
147Bone marrow hypocellularity (HP:0005528)1.83022423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.60284428
2KIT3.50161802
3EEF2K2.94098263
4FLT32.82774252
5NME22.54287928
6BTK2.44482004
7CSF1R2.34472575
8WEE12.22444835
9MAP2K32.22336402
10TEC2.17140014
11STK161.98809670
12CDK191.89935669
13IRAK41.81136839
14TGFBR21.76137281
15SYK1.74227957
16TAOK11.72919869
17PIM21.72735945
18TGFBR11.72283441
19TNIK1.63580082
20PKN21.63131190
21ERN11.60979048
22SCYL21.60631699
23BLK1.58804513
24ACVR1B1.58790019
25RPS6KB21.54682081
26TAOK21.50093768
27FES1.45999585
28MAP3K11.45721157
29ZAP701.45675604
30PRPF4B1.45120638
31TBK11.44485511
32TESK21.39487779
33CSK1.37040453
34MAP3K101.35472302
35VRK21.35409065
36VRK11.35394151
37MUSK1.35377783
38LRRK21.35262446
39IKBKE1.29962655
40MATK1.26936082
41JAK31.24789226
42TYK21.21139274
43DYRK31.19854500
44BRSK21.17642934
45NEK21.17409535
46CAMKK21.16771961
47MARK31.15316699
48CDC71.12792144
49TAOK31.11128301
50TRIB31.10476539
51EIF2AK31.10032476
52MAPKAPK31.08290029
53ITK1.07968916
54CDK71.07103337
55RIPK41.07101232
56LYN1.04646720
57PIM11.03828363
58NUAK11.03436394
59BUB11.02813749
60EIF2AK11.01760722
61SMG10.99489407
62MAPKAPK50.97646888
63KDR0.97619451
64FGR0.96458964
65TIE10.95164841
66GRK60.94397645
67IKBKB0.92421902
68MAP3K140.91295647
69STK100.90866968
70LCK0.89093985
71CDK40.86928106
72CCNB10.86900684
73TXK0.85122504
74DAPK20.84970202
75HCK0.82434397
76PAK40.82354691
77BCKDK0.81694386
78CLK10.80324953
79PRKCQ0.79584508
80RPS6KA40.79378290
81PRKD20.79329475
82ATR0.78707623
83TLK10.78280773
84MKNK10.78043217
85TNK20.76098344
86PTK2B0.73538717
87CDK80.72725026
88MAP3K120.72143962
89NLK0.71583936
90IRAK30.70063416
91SIK30.69990626
92MAPK40.69186706
93STK40.68042450
94MAPK120.66857404
95MAP3K110.66816183
96MAP3K70.63996825
97MAP3K130.63723162
98SIK20.63227489
99PASK0.62420132
100RPS6KA60.61825024
101MAP2K60.58399491
102PRKG20.56800907
103BMX0.55669153
104BMPR20.55534873
105MAP2K20.55512270
106RPS6KL10.55403822
107RPS6KC10.55403822
108HIPK20.55149379
109PDK10.54333284
110MAP3K80.54078186
111RAF10.53975496
112MAP3K60.53725601
113PIK3CG0.51488839
114ILK0.50909625
115MAP2K40.49788330
116MARK20.48879645
117MAPK110.48827608
118BRSK10.48707531
119JAK10.48202975
120CAMK10.47215143
121ADRBK20.46129430
122IRAK10.45379161
123TSSK60.43492292
124DAPK10.42320952
125STK110.41479470
126MAP3K30.40974954
127MAPKAPK20.40956354
128MAP3K50.40833154
129AURKB0.38903062
130TRPM70.38846120
131PDPK10.37408211
132EPHB10.36739972
133FRK0.36100464
134PTK60.35471600
135IRAK20.33405942
136FYN0.32927430
137SRPK10.32164218
138PRKCD0.31217974
139JAK20.30910156
140MKNK20.30849613
141MAP4K20.30260164

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.67405604
2DNA replication_Homo sapiens_hsa030304.59539477
3Mismatch repair_Homo sapiens_hsa034303.23357797
4Base excision repair_Homo sapiens_hsa034102.85930695
5Allograft rejection_Homo sapiens_hsa053302.65426755
6Primary immunodeficiency_Homo sapiens_hsa053402.44954052
7Graft-versus-host disease_Homo sapiens_hsa053322.44788273
8Autoimmune thyroid disease_Homo sapiens_hsa053202.35458851
9Homologous recombination_Homo sapiens_hsa034402.34062143
10B cell receptor signaling pathway_Homo sapiens_hsa046622.19258742
11Nucleotide excision repair_Homo sapiens_hsa034202.05126989
12Type I diabetes mellitus_Homo sapiens_hsa049402.05087784
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01781814
14Spliceosome_Homo sapiens_hsa030402.01328386
15Pyrimidine metabolism_Homo sapiens_hsa002401.96093081
16Leishmaniasis_Homo sapiens_hsa051401.76932283
17Non-homologous end-joining_Homo sapiens_hsa034501.69604041
18RNA polymerase_Homo sapiens_hsa030201.66419231
19Other glycan degradation_Homo sapiens_hsa005111.66337877
20Hematopoietic cell lineage_Homo sapiens_hsa046401.60923873
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60149893
22Antigen processing and presentation_Homo sapiens_hsa046121.55544969
23African trypanosomiasis_Homo sapiens_hsa051431.49734844
24Herpes simplex infection_Homo sapiens_hsa051681.48135466
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.45053308
26Cell cycle_Homo sapiens_hsa041101.44799675
27Fanconi anemia pathway_Homo sapiens_hsa034601.43379249
28Measles_Homo sapiens_hsa051621.41150558
29N-Glycan biosynthesis_Homo sapiens_hsa005101.40744269
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40618736
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38417638
32Acute myeloid leukemia_Homo sapiens_hsa052211.36608241
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32023795
34* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27169129
35Proteasome_Homo sapiens_hsa030501.26264735
36Systemic lupus erythematosus_Homo sapiens_hsa053221.25580803
37Osteoclast differentiation_Homo sapiens_hsa043801.24334640
38Sulfur relay system_Homo sapiens_hsa041221.23062461
39Pentose phosphate pathway_Homo sapiens_hsa000301.22705831
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.20326681
41Viral myocarditis_Homo sapiens_hsa054161.17917871
42RNA degradation_Homo sapiens_hsa030181.17822689
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.17194876
44Rheumatoid arthritis_Homo sapiens_hsa053231.14830648
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14056636
46Platelet activation_Homo sapiens_hsa046111.13873121
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.13185848
48One carbon pool by folate_Homo sapiens_hsa006701.13178522
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11300141
50Phagosome_Homo sapiens_hsa041451.11279507
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09428841
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09271488
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.06407052
54Regulation of autophagy_Homo sapiens_hsa041401.05523675
55RNA transport_Homo sapiens_hsa030131.04810715
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04204607
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02828341
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01719473
59Pertussis_Homo sapiens_hsa051330.99930968
60Purine metabolism_Homo sapiens_hsa002300.98210969
61Legionellosis_Homo sapiens_hsa051340.96254321
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95664724
63p53 signaling pathway_Homo sapiens_hsa041150.94408520
64Shigellosis_Homo sapiens_hsa051310.92692937
65Epstein-Barr virus infection_Homo sapiens_hsa051690.92093871
66Hepatitis B_Homo sapiens_hsa051610.88972621
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88722417
68Influenza A_Homo sapiens_hsa051640.87104074
69Folate biosynthesis_Homo sapiens_hsa007900.85988386
70Apoptosis_Homo sapiens_hsa042100.85043324
71TNF signaling pathway_Homo sapiens_hsa046680.82350024
72Protein export_Homo sapiens_hsa030600.81333160
73Chronic myeloid leukemia_Homo sapiens_hsa052200.79749429
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78804174
75Caffeine metabolism_Homo sapiens_hsa002320.78430935
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73540993
77Malaria_Homo sapiens_hsa051440.73431753
78Viral carcinogenesis_Homo sapiens_hsa052030.73262835
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72734822
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71555634
81Toxoplasmosis_Homo sapiens_hsa051450.70377018
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70163553
83Tuberculosis_Homo sapiens_hsa051520.69039644
84Arachidonic acid metabolism_Homo sapiens_hsa005900.67584563
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66990925
86Non-small cell lung cancer_Homo sapiens_hsa052230.66779563
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.64097305
88Galactose metabolism_Homo sapiens_hsa000520.62146346
89Thyroid cancer_Homo sapiens_hsa052160.62075964
90Selenocompound metabolism_Homo sapiens_hsa004500.61792994
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60798858
92Staphylococcus aureus infection_Homo sapiens_hsa051500.60488172
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59929681
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59839499
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58999145
96Basal transcription factors_Homo sapiens_hsa030220.57276271
97Collecting duct acid secretion_Homo sapiens_hsa049660.55492535
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.55176581
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54602978
100HTLV-I infection_Homo sapiens_hsa051660.54225258
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.53788842
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52613670
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.50865015
104Endocytosis_Homo sapiens_hsa041440.50037368
105VEGF signaling pathway_Homo sapiens_hsa043700.49802902
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48611835
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.48603752
108Asthma_Homo sapiens_hsa053100.45535510
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45417121
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45176062
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.43327066
112Chemokine signaling pathway_Homo sapiens_hsa040620.41992206
113Prolactin signaling pathway_Homo sapiens_hsa049170.41406499
114Salmonella infection_Homo sapiens_hsa051320.41307537
115mTOR signaling pathway_Homo sapiens_hsa041500.41103829
116Lysosome_Homo sapiens_hsa041420.40823137
117Olfactory transduction_Homo sapiens_hsa047400.40543326
118Pancreatic cancer_Homo sapiens_hsa052120.40198254
119Alcoholism_Homo sapiens_hsa050340.38950916
120Small cell lung cancer_Homo sapiens_hsa052220.38485763
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35977647
122Inositol phosphate metabolism_Homo sapiens_hsa005620.34576509
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34367778
124T cell receptor signaling pathway_Homo sapiens_hsa046600.33674606
125Renin-angiotensin system_Homo sapiens_hsa046140.32979619
126ABC transporters_Homo sapiens_hsa020100.32329144
127Hepatitis C_Homo sapiens_hsa051600.31429759
128Ether lipid metabolism_Homo sapiens_hsa005650.26399149
129FoxO signaling pathway_Homo sapiens_hsa040680.25918506
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24569243
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.21394020
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21139829
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20362399
134HIF-1 signaling pathway_Homo sapiens_hsa040660.20275499

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