LYN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.19641813
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.19641813
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.19641813
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.19641813
5modulation by symbiont of host immune response (GO:0052553)6.19641813
6positive regulation by symbiont of host defense response (GO:0052509)6.19641813
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.83107089
8regulation of interferon-beta biosynthetic process (GO:0045357)5.69153415
9macrophage activation involved in immune response (GO:0002281)5.28495232
10neutrophil activation involved in immune response (GO:0002283)5.07114533
11positive regulation of interferon-alpha production (GO:0032727)4.81120175
12immunoglobulin mediated immune response (GO:0016064)4.79490518
13antigen processing and presentation of endogenous antigen (GO:0019883)4.78143122
14detection of other organism (GO:0098543)4.71146891
15regulation of interferon-alpha production (GO:0032647)4.56409422
16positive regulation of gamma-delta T cell activation (GO:0046645)4.43631509
17response to peptidoglycan (GO:0032494)4.43362270
18microglial cell activation (GO:0001774)4.40900344
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.40526840
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40526840
21respiratory burst (GO:0045730)4.39024161
22detection of bacterium (GO:0016045)4.36121333
23positive regulation of B cell differentiation (GO:0045579)4.28603449
24detection of external biotic stimulus (GO:0098581)4.26379901
25* regulation of B cell receptor signaling pathway (GO:0050855)4.23630630
26response to host immune response (GO:0052572)4.22910835
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.22910835
28neutrophil activation (GO:0042119)4.03569543
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95795490
30response to host (GO:0075136)3.95795490
31response to host defenses (GO:0052200)3.95795490
32* B cell receptor signaling pathway (GO:0050853)3.94225955
33granulocyte activation (GO:0036230)3.89504055
34regulation of B cell differentiation (GO:0045577)3.85619149
35macrophage activation (GO:0042116)3.81536009
36detection of biotic stimulus (GO:0009595)3.78445276
37cellular extravasation (GO:0045123)3.76151833
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.74540406
39positive regulation of antigen processing and presentation (GO:0002579)3.74507583
40myeloid cell activation involved in immune response (GO:0002275)3.73749063
41negative regulation of T cell mediated immunity (GO:0002710)3.66774609
42positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.66338019
43B cell mediated immunity (GO:0019724)3.55199500
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.53669132
45positive regulation of mast cell degranulation (GO:0043306)3.53669132
46positive regulation of mast cell activation (GO:0033005)3.50841199
47* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50425650
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.48201368
49response to muramyl dipeptide (GO:0032495)3.45608670
50positive regulation of interferon-beta production (GO:0032728)3.45525335
51positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.43417047
52defense response to protozoan (GO:0042832)3.42059416
53cellular response to zinc ion (GO:0071294)3.39980508
54interferon-gamma-mediated signaling pathway (GO:0060333)3.38526114
55T-helper 1 type immune response (GO:0042088)3.33643016
56negative regulation of leukocyte mediated immunity (GO:0002704)3.33520719
57response to type I interferon (GO:0034340)3.31938134
58regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.30954734
59type I interferon signaling pathway (GO:0060337)3.29494561
60cellular response to type I interferon (GO:0071357)3.29494561
61leukocyte aggregation (GO:0070486)3.28374681
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.27165523
63production of molecular mediator involved in inflammatory response (GO:0002532)3.25969637
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25246948
65Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23737415
66negative regulation of erythrocyte differentiation (GO:0045647)3.23444791
67germinal center formation (GO:0002467)3.22403533
68response to interleukin-15 (GO:0070672)3.22216178
69regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.19565643
70regulation of antigen processing and presentation (GO:0002577)3.17931264
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17548714
72I-kappaB phosphorylation (GO:0007252)3.16562553
73regulation of tolerance induction (GO:0002643)3.16514828
74positive regulation of toll-like receptor signaling pathway (GO:0034123)3.14460788
75T cell migration (GO:0072678)3.11168597
76response to protozoan (GO:0001562)3.11022102
77mature B cell differentiation (GO:0002335)3.10874118
78regulation of interleukin-12 biosynthetic process (GO:0045075)3.07892895
79negative regulation of granulocyte differentiation (GO:0030853)3.07886302
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07689307
81regulation of T cell tolerance induction (GO:0002664)3.05380310
82positive regulation of type 2 immune response (GO:0002830)3.05097907
83regulation of T-helper 2 cell differentiation (GO:0045628)3.04809662
84myeloid leukocyte activation (GO:0002274)3.04805822
85pinocytosis (GO:0006907)3.04629356
86* regulation of mast cell degranulation (GO:0043304)3.04225869
87leukocyte migration involved in inflammatory response (GO:0002523)3.03841266
88* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03087556
89antigen processing and presentation via MHC class Ib (GO:0002475)3.02247011
90* regulation of mast cell activation (GO:0033003)3.00045863
91regulation of gamma-delta T cell activation (GO:0046643)2.99257132
92myeloid leukocyte mediated immunity (GO:0002444)2.98350984
93neutrophil mediated immunity (GO:0002446)2.97403263
94negative regulation of phagocytosis (GO:0050765)2.96936458
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96797593
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95444905
97myeloid dendritic cell activation (GO:0001773)2.94064430
98regulation of alpha-beta T cell proliferation (GO:0046640)2.93115705
99cellular response to exogenous dsRNA (GO:0071360)2.92948924
100natural killer cell mediated cytotoxicity (GO:0042267)2.92884636
101natural killer cell mediated immunity (GO:0002228)2.92884636
102regulation of gamma-delta T cell differentiation (GO:0045586)2.92614532
103negative regulation of interleukin-12 production (GO:0032695)2.91726749
104leukocyte degranulation (GO:0043299)2.91401616
105negative regulation of cytokine production involved in immune response (GO:0002719)2.90560765
106* regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89519472
107cellular response to interleukin-15 (GO:0071350)2.88077147
108hydrogen peroxide biosynthetic process (GO:0050665)2.87644625
109positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86878774
110myeloid dendritic cell differentiation (GO:0043011)2.84826355
111leukocyte mediated cytotoxicity (GO:0001909)2.84346141
112* regulation of mast cell activation involved in immune response (GO:0033006)2.83333031
113negative thymic T cell selection (GO:0045060)2.82812507
114positive regulation of leukocyte degranulation (GO:0043302)2.82246581
115regulation of interleukin-12 production (GO:0032655)2.82067655
116negative regulation of mast cell activation (GO:0033004)2.81800561
117negative regulation of cell killing (GO:0031342)2.80088535
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80088535
119regulation of interleukin-8 biosynthetic process (GO:0045414)2.77258693
120positive regulation of cellular amide metabolic process (GO:0034250)2.75313491
121superoxide anion generation (GO:0042554)2.73895052
122G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.72685643
123regulation of interferon-beta production (GO:0032648)2.70228487
124regulation of interferon-gamma biosynthetic process (GO:0045072)2.69619467
125neutrophil chemotaxis (GO:0030593)2.69144402
126leukocyte cell-cell adhesion (GO:0007159)2.68672596
127NIK/NF-kappaB signaling (GO:0038061)2.68128081
128adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.67949973
129reactive oxygen species biosynthetic process (GO:1903409)2.67566070
130cellular response to interferon-beta (GO:0035458)2.66454712
131detection of molecule of bacterial origin (GO:0032490)2.66126433
132negative regulation of interleukin-6 production (GO:0032715)2.64280335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.33268914
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.76596906
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.51539821
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.15572246
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87987582
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.86057500
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.65529923
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.62564159
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43917958
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.29625583
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23542419
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.10814426
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08188324
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.07025871
15SCL_19346495_ChIP-Seq_HPC-7_Human2.69591063
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.63438989
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57260454
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51968598
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.43437793
20* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39972814
21* SPI1_23547873_ChIP-Seq_NB4_Human2.38029294
22VDR_21846776_ChIP-Seq_THP-1_Human2.30833969
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27035037
24GATA1_22025678_ChIP-Seq_K562_Human2.23944772
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20148279
26VDR_24763502_ChIP-Seq_THP-1_Human2.13317665
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12363920
28MYB_26560356_Chip-Seq_TH2_Human2.09452854
29RUNX_20019798_ChIP-Seq_JUKART_Human2.06604165
30E2F7_22180533_ChIP-Seq_HELA_Human2.02500735
31MAF_26560356_Chip-Seq_TH1_Human2.00854227
32MYC_22102868_ChIP-Seq_BL_Human1.99835476
33* SPI1_23127762_ChIP-Seq_K562_Human1.95412632
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93418482
35* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92968512
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.92107886
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90895471
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87124002
39MYB_26560356_Chip-Seq_TH1_Human1.84340479
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.83327002
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77884154
42PU_27001747_Chip-Seq_BMDM_Mouse1.71147788
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69220557
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68005696
45UTX_26944678_Chip-Seq_JUKART_Human1.58331097
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57806011
47TCF7_22412390_ChIP-Seq_EML_Mouse1.56700274
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55930277
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46617952
50* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45524499
51* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43875708
52* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39713699
53* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36741516
54VDR_24787735_ChIP-Seq_THP-1_Human1.36679688
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32851921
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31180857
57GATA3_27048872_Chip-Seq_THYMUS_Human1.29953349
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.24334141
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.23600945
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22936487
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22334817
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21056972
63* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21030121
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.21003243
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20666848
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17447833
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.13349382
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13148950
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12622395
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11455644
71GATA3_26560356_Chip-Seq_TH2_Human1.10556177
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10422619
73* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10417343
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09438228
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06046828
76MAF_26560356_Chip-Seq_TH2_Human1.05420074
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05385328
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04361635
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.00569145
80* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00263923
81* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99644493
82* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99208183
83KDM2B_26808549_Chip-Seq_DND41_Human0.98414841
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97322290
85PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94405018
86* ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94272611
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93936243
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93606148
89* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93275426
90GATA1_19941826_ChIP-Seq_K562_Human0.92357342
91* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91748982
92* GATA2_19941826_ChIP-Seq_K562_Human0.91448796
93* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90338933
94* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87325207
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86669407
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.85395542
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82666846
98RXR_22158963_ChIP-Seq_LIVER_Mouse0.82004203
99SPI1_20517297_ChIP-Seq_HL60_Human0.81667174
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81360327
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80952832
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80951171
103GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80865945
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80738476
105LXR_22158963_ChIP-Seq_LIVER_Mouse0.80695336
106SMRT_27268052_Chip-Seq_Bcells_Human0.78596230
107BCL6_27268052_Chip-Seq_Bcells_Human0.74672589
108TFEB_21752829_ChIP-Seq_HELA_Human0.72793057
109* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72137246
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.71818695
111NCOR1_26117541_ChIP-Seq_K562_Human0.71525858
112* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71215186
113BCOR_27268052_Chip-Seq_Bcells_Human0.70912246
114* LXR_22292898_ChIP-Seq_THP-1_Human0.69709685
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.68879119
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65799633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.41727319
2MP0003436_decreased_susceptibility_to3.41713374
3MP0001790_abnormal_immune_system2.99925515
4MP0005387_immune_system_phenotype2.99925515
5MP0009785_altered_susceptibility_to2.99159264
6* MP0001800_abnormal_humoral_immune2.99159263
7* MP0002419_abnormal_innate_immunity2.97866154
8* MP0005000_abnormal_immune_tolerance2.90203717
9* MP0002452_abnormal_antigen_presenting2.86748252
10MP0002148_abnormal_hypersensitivity_rea2.84053639
11MP0000685_abnormal_immune_system2.75269047
12MP0005025_abnormal_response_to2.70632981
13MP0005671_abnormal_response_to2.67952165
14* MP0002723_abnormal_immune_serum2.55149739
15MP0006082_CNS_inflammation2.53411103
16* MP0003303_peritoneal_inflammation2.50769082
17MP0005058_abnormal_lysosome_morphology2.49804355
18MP0003724_increased_susceptibility_to2.43631969
19MP0003191_abnormal_cellular_cholesterol2.42150732
20MP0005464_abnormal_platelet_physiology2.40707724
21* MP0002420_abnormal_adaptive_immunity2.39278725
22* MP0001819_abnormal_immune_cell2.39145337
23MP0004510_myositis2.16828181
24MP0001853_heart_inflammation2.02989908
25MP0003300_gastrointestinal_ulcer2.01135880
26MP0008260_abnormal_autophagy2.01051819
27MP0002405_respiratory_system_inflammati1.92706933
28MP0009278_abnormal_bone_marrow1.91315783
29MP0005451_abnormal_body_composition1.91000773
30* MP0002398_abnormal_bone_marrow1.87993642
31* MP0000716_abnormal_immune_system1.87960539
32MP0001533_abnormal_skeleton_physiology1.86694443
33* MP0001845_abnormal_inflammatory_respons1.85371891
34MP0002166_altered_tumor_susceptibility1.82060204
35MP0003172_abnormal_lysosome_physiology1.81695963
36* MP0000689_abnormal_spleen_morphology1.71920916
37MP0002396_abnormal_hematopoietic_system1.68769801
38MP0010155_abnormal_intestine_physiology1.68343280
39MP0004947_skin_inflammation1.67080688
40MP0009840_abnormal_foam_cell1.64670276
41MP0005397_hematopoietic_system_phenotyp1.64101980
42MP0001545_abnormal_hematopoietic_system1.64101980
43MP0002006_tumorigenesis1.60714866
44MP0000343_altered_response_to1.60497293
45* MP0008469_abnormal_protein_level1.58895673
46* MP0002429_abnormal_blood_cell1.57343900
47MP0003183_abnormal_peptide_metabolism1.55331363
48* MP0002722_abnormal_immune_system1.50644984
49MP0009764_decreased_sensitivity_to1.49503138
50MP0000465_gastrointestinal_hemorrhage1.49442514
51MP0009333_abnormal_splenocyte_physiolog1.46655860
52MP0003075_altered_response_to1.43338045
53MP0004808_abnormal_hematopoietic_stem1.42287546
54MP0002132_abnormal_respiratory_system1.38048657
55MP0001873_stomach_inflammation1.34343412
56MP0003448_altered_tumor_morphology1.32317116
57MP0005310_abnormal_salivary_gland1.28061560
58MP0008004_abnormal_stomach_pH1.21932695
59MP0005167_abnormal_blood-brain_barrier1.18237083
60MP0003828_pulmonary_edema1.15356194
61MP0005166_decreased_susceptibility_to1.14965980
62MP0002138_abnormal_hepatobiliary_system1.10913066
63MP0002998_abnormal_bone_remodeling1.10798356
64MP0000569_abnormal_digit_pigmentation1.08726831
65MP0003566_abnormal_cell_adhesion1.08248431
66MP0002277_abnormal_respiratory_mucosa1.08091262
67MP0002933_joint_inflammation1.08057645
68MP0000858_altered_metastatic_potential1.08017768
69MP0001851_eye_inflammation1.07552067
70MP0003763_abnormal_thymus_physiology1.05804947
71MP0005174_abnormal_tail_pigmentation1.03110443
72MP0006054_spinal_hemorrhage1.01039341
73MP0004381_abnormal_hair_follicle1.00466721
74MP0000249_abnormal_blood_vessel1.00434422
75MP0009763_increased_sensitivity_to0.99373053
76MP0010307_abnormal_tumor_latency0.97105547
77MP0001879_abnormal_lymphatic_vessel0.90117377
78MP0003806_abnormal_nucleotide_metabolis0.89261151
79MP0010352_gastrointestinal_tract_polyps0.88328241
80MP0000604_amyloidosis0.88107540
81MP0005164_abnormal_response_to0.87305464
82MP0000490_abnormal_crypts_of0.87278116
83MP0000767_abnormal_smooth_muscle0.86928630
84MP0000703_abnormal_thymus_morphology0.84667221
85MP0003656_abnormal_erythrocyte_physiolo0.83544338
86MP0003221_abnormal_cardiomyocyte_apopto0.82637545
87MP0005076_abnormal_cell_differentiation0.81103322
88MP0003866_abnormal_defecation0.80634829
89MP0005390_skeleton_phenotype0.79801254
90MP0002332_abnormal_exercise_endurance0.79597078
91MP0009765_abnormal_xenobiotic_induced0.79269746
92MP0002928_abnormal_bile_duct0.79075271
93MP0004782_abnormal_surfactant_physiolog0.78981851
94MP0003045_fibrosis0.77122072
95MP0005023_abnormal_wound_healing0.76644320
96MP0003279_aneurysm0.76218840
97MP0004883_abnormal_blood_vessel0.75917497
98* MP0002136_abnormal_kidney_physiology0.74552017
99MP0002254_reproductive_system_inflammat0.74222954
100* MP0003690_abnormal_glial_cell0.73877090
101* MP0000609_abnormal_liver_physiology0.72137527
102MP0005075_abnormal_melanosome_morpholog0.70981949
103MP0003453_abnormal_keratinocyte_physiol0.70166446
104MP0001915_intracranial_hemorrhage0.69932767
105MP0003091_abnormal_cell_migration0.69820481
106* MP0001663_abnormal_digestive_system0.67890623
107MP0002019_abnormal_tumor_incidence0.67305457
108MP0008874_decreased_physiological_sensi0.66600209
109MP0008873_increased_physiological_sensi0.65062672
110MP0000598_abnormal_liver_morphology0.64076147
111MP0000371_diluted_coat_color0.60729193
112MP0003186_abnormal_redox_activity0.60123840
113MP0003795_abnormal_bone_structure0.59631114
114MP0000015_abnormal_ear_pigmentation0.59320172
115MP0005319_abnormal_enzyme/_coenzyme0.53210373
116MP0002009_preneoplasia0.52981066
117MP0005376_homeostasis/metabolism_phenot0.48536990

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.72926135
2Recurrent bacterial skin infections (HP:0005406)6.26446659
3Eczematoid dermatitis (HP:0000976)5.94563184
4Recurrent gram-negative bacterial infections (HP:0005420)5.16335435
5Systemic lupus erythematosus (HP:0002725)4.63405199
6Cellulitis (HP:0100658)4.31119339
7Abnormality of macrophages (HP:0004311)4.13413566
8Recurrent skin infections (HP:0001581)4.08643708
9Gastrointestinal infarctions (HP:0005244)4.01220202
10Mediastinal lymphadenopathy (HP:0100721)3.97523469
11Recurrent fungal infections (HP:0002841)3.88486113
12Colitis (HP:0002583)3.87134335
13Myositis (HP:0100614)3.86350159
14Recurrent viral infections (HP:0004429)3.82655351
15Keratoconjunctivitis sicca (HP:0001097)3.78457741
16Encephalitis (HP:0002383)3.62440290
17Glomerulonephritis (HP:0000099)3.60264370
18Elevated erythrocyte sedimentation rate (HP:0003565)3.60110372
19Agammaglobulinemia (HP:0004432)3.57274021
20Increased cerebral lipofuscin (HP:0011813)3.54431185
21Keratoconjunctivitis (HP:0001096)3.51042194
22Vacuolated lymphocytes (HP:0001922)3.50848160
23Autoimmune thrombocytopenia (HP:0001973)3.45812333
24Hematochezia (HP:0002573)3.43476091
25Vasculitis (HP:0002633)3.39447120
26Obstructive lung disease (HP:0006536)3.38553003
27Chronic obstructive pulmonary disease (HP:0006510)3.38553003
28Meningitis (HP:0001287)3.37455394
29Inflammation of the large intestine (HP:0002037)3.37369628
30IgM deficiency (HP:0002850)3.27500219
31Gingivitis (HP:0000230)3.27198242
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.26871045
33Orchitis (HP:0100796)3.23290501
34Gastrointestinal inflammation (HP:0004386)3.19527017
35T lymphocytopenia (HP:0005403)3.19226914
36Spontaneous hematomas (HP:0007420)3.18090822
37Interstitial pulmonary disease (HP:0006530)3.17417352
38Osteomyelitis (HP:0002754)3.15915353
39Chest pain (HP:0100749)3.11169537
40Gastrointestinal stroma tumor (HP:0100723)3.11074861
41Abnormality of T cell number (HP:0011839)3.09569042
42Chronic otitis media (HP:0000389)3.08348667
43Recurrent cutaneous fungal infections (HP:0011370)3.00464423
44Chronic mucocutaneous candidiasis (HP:0002728)3.00464423
45Abnormality of glycolipid metabolism (HP:0010969)2.99572489
46Abnormality of liposaccharide metabolism (HP:0010968)2.99572489
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.99572489
48Pustule (HP:0200039)2.97822840
49Periodontitis (HP:0000704)2.95512290
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.80973620
51Recurrent bronchitis (HP:0002837)2.80376055
52Dysostosis multiplex (HP:0000943)2.80278417
53Recurrent pneumonia (HP:0006532)2.77569593
54Optic neuritis (HP:0100653)2.75153976
55Retrobulbar optic neuritis (HP:0100654)2.75153976
56Anorexia (HP:0002039)2.67554250
57Episodic fever (HP:0001954)2.64812473
58Abnormality of T cells (HP:0002843)2.64673713
59Increased IgM level (HP:0003496)2.63061518
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.61930792
61Myocardial infarction (HP:0001658)2.61652230
62Amyloidosis (HP:0011034)2.61024169
63Pulmonary embolism (HP:0002204)2.60406851
64Gangrene (HP:0100758)2.56560622
65Urticaria (HP:0001025)2.54453357
66Recurrent lower respiratory tract infections (HP:0002783)2.53614441
67Petechiae (HP:0000967)2.53367512
68Complement deficiency (HP:0004431)2.52358425
69Disinhibition (HP:0000734)2.50526097
70Stomatitis (HP:0010280)2.47323586
71Gingival bleeding (HP:0000225)2.46225137
72Pulmonary infiltrates (HP:0002113)2.45991683
73Lymphopenia (HP:0001888)2.45900295
74Arterial thrombosis (HP:0004420)2.43400716
75Prolonged bleeding time (HP:0003010)2.42761010
76Peritonitis (HP:0002586)2.42400030
77Basal ganglia calcification (HP:0002135)2.42004977
78Axonal loss (HP:0003447)2.41029740
79Granulocytopenia (HP:0001913)2.39562464
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.38421773
81Abnormality of complement system (HP:0005339)2.37247048
82Abnormality of the pleura (HP:0002103)2.35996168
83Urinary glycosaminoglycan excretion (HP:0003541)2.35440908
84Mucopolysacchariduria (HP:0008155)2.35440908
85Nephritis (HP:0000123)2.34405334
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34235851
87Epistaxis (HP:0000421)2.31703080
88Thrombocytosis (HP:0001894)2.31351453
89Recurrent sinusitis (HP:0011108)2.31248296
90Papilloma (HP:0012740)2.30482545
91Verrucae (HP:0200043)2.30482545
92Leukocytosis (HP:0001974)2.30304622
93Abnormal platelet function (HP:0011869)2.28282142
94Impaired platelet aggregation (HP:0003540)2.28282142
95Emphysema (HP:0002097)2.27803372
96Hypochromic anemia (HP:0001931)2.23512232
97Increased serum ferritin (HP:0003281)2.22659264
98Abnormality of the peritoneum (HP:0002585)2.22334660
99Hypochromic microcytic anemia (HP:0004840)2.22173208
100Prostate neoplasm (HP:0100787)2.21892107
101Purpura (HP:0000979)2.21372487
102Sepsis (HP:0100806)2.21176065
103Joint hemorrhage (HP:0005261)2.20004502
104Viral hepatitis (HP:0006562)2.19476141
105Abnormality of polysaccharide metabolism (HP:0011012)2.18931877
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18931877
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18931877
108Skin ulcer (HP:0200042)2.18688954
109Abnormality of the nasal mucosa (HP:0000433)2.18248485
110Agnosia (HP:0010524)2.17902352
111Panhypogammaglobulinemia (HP:0003139)2.17508022
112Autoimmune hemolytic anemia (HP:0001890)2.17022524
113Thyroiditis (HP:0100646)2.16351212
114Hypergammaglobulinemia (HP:0010702)2.15366705
115Osteolytic defects of the phalanges of the hand (HP:0009771)2.15267662
116Osteolytic defects of the hand bones (HP:0009699)2.15267662
117Restrictive lung disease (HP:0002091)2.14561009
118Vertigo (HP:0002321)2.14148785
119Abnormality of T cell physiology (HP:0011840)2.13539016
120Amaurosis fugax (HP:0100576)2.13185509
121Chronic diarrhea (HP:0002028)2.12543581
122Slow saccadic eye movements (HP:0000514)2.11959517
123Increased IgE level (HP:0003212)2.10675601
124Loss of speech (HP:0002371)2.10356619
125Eosinophilia (HP:0001880)2.10063562
126Glomerulopathy (HP:0100820)2.08998964
127Abnormality of the endocardium (HP:0004306)2.07645795
128Polyneuropathy (HP:0001271)2.06862415
129Hemoptysis (HP:0002105)2.05714034
130Hepatosplenomegaly (HP:0001433)2.05064432
131Nasal polyposis (HP:0100582)2.04189922
132Abnormality of iron homeostasis (HP:0011031)2.03961736
133IgA deficiency (HP:0002720)2.02739437
134Premature loss of primary teeth (HP:0006323)1.95929789
135Keratitis (HP:0000491)1.93879053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.01826221
2BLK3.43570894
3ERN13.32706608
4TYK23.19744457
5RIPK43.19324985
6IRAK42.98669841
7TGFBR22.97992927
8MAP3K142.97863649
9TBK12.76513597
10KIT2.55001386
11PRPF4B2.50069962
12IRAK32.49343642
13CSF1R2.48791053
14JAK12.07689662
15STK101.99155550
16BTK1.92522189
17IKBKE1.82983360
18SYK1.78453660
19BMPR21.76079341
20IKBKB1.75606853
21JAK31.67954916
22MAP3K101.66213702
23ZAP701.61481558
24TNK21.57166392
25TAOK11.51497539
26MAP3K131.50743173
27HCK1.49383381
28NEK91.45862508
29TEC1.44306351
30GRK61.44070328
31TAOK31.43796766
32MAP2K31.43614366
33EPHB11.42079127
34FES1.38422840
35IRAK11.38418427
36LRRK21.31183881
37* LYN1.29597555
38MAP3K11.28960801
39CLK11.28067815
40PIM11.23912654
41TXK1.22541205
42RPS6KA41.21715305
43* CSK1.21695437
44IRAK21.18328632
45KSR21.11913570
46TAOK21.10596479
47LCK1.10274826
48CHUK1.10190459
49KDR1.07012091
50PIM21.06048822
51CAMK1D1.04230037
52STK41.01933878
53JAK20.99232950
54ITK0.96676827
55SIK20.96632617
56PKN20.95264532
57FGFR40.95034945
58FGR0.94958764
59FGFR30.92648800
60MARK30.91337941
61TRIB30.86613920
62GRK70.81488721
63CDC42BPA0.77775180
64PTK60.75783476
65MAP3K50.73995962
66MARK20.73282658
67TRPM70.71890342
68FLT30.69748063
69MAP3K60.69242188
70MAP3K20.67928736
71EEF2K0.67557816
72CDK190.66847741
73MAP3K30.64512828
74CDK60.64045961
75PAK40.62208189
76ABL10.61658612
77MST40.57193714
78EGFR0.56208431
79EPHA30.56140593
80PRKCD0.53677638
81RIPK10.53292334
82PTK2B0.51199176
83TTN0.49541466
84PRKD20.49349478
85SGK30.49232059
86STK30.49038051
87HIPK20.48962512
88MAPKAPK20.48936957
89CAMK1G0.47633032
90PDK10.46636744
91MAPK40.46574400
92CDK40.46172475
93MAPK120.46026396
94RAF10.45965694
95TESK20.45734879
96SMG10.45660805
97RPS6KA60.44065924
98TIE10.42332122
99PRKCQ0.41680047
100NLK0.40239156
101MAP3K80.39731400
102CDK120.39240633
103DAPK20.38012932
104CDK90.37572618
105NME20.36782833
106SGK20.36691829
107MAP3K70.35928461
108MOS0.35480672
109KSR10.35375527
110NEK20.35214511
111PIK3CG0.34842190
112TGFBR10.34539487
113ACVR1B0.34499453
114STK240.34301123
115DYRK1B0.34292838
116MAP2K40.34269786
117SCYL20.34053679
118STK110.34022430
119YES10.33770098
120MAP2K60.33492512
121MAPK150.33417873
122RPS6KL10.33391800
123RPS6KC10.33391800
124MAPK110.32501044
125EIF2AK20.31813182
126MAP3K110.31555412
127SIK30.31203232
128MAPK70.31093287
129DYRK30.30575788
130CAMKK20.30473093
131GRK10.30362185
132FYN0.29176185
133PRKCH0.28683263
134PBK0.28468666
135PDPK10.28417486
136PRKAA20.27858272

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.62275432
2Leishmaniasis_Homo sapiens_hsa051403.38721861
3* B cell receptor signaling pathway_Homo sapiens_hsa046622.93572797
4Osteoclast differentiation_Homo sapiens_hsa043802.75736071
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.54984163
6* NF-kappa B signaling pathway_Homo sapiens_hsa040642.41705982
7Pertussis_Homo sapiens_hsa051332.24435961
8Other glycan degradation_Homo sapiens_hsa005112.17474494
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.14048437
10Legionellosis_Homo sapiens_hsa051342.12402106
11Primary immunodeficiency_Homo sapiens_hsa053402.12208858
12Tuberculosis_Homo sapiens_hsa051522.12048075
13Hematopoietic cell lineage_Homo sapiens_hsa046402.01320888
14Measles_Homo sapiens_hsa051621.98077120
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.97168942
16Malaria_Homo sapiens_hsa051441.94903214
17Antigen processing and presentation_Homo sapiens_hsa046121.92913104
18Lysosome_Homo sapiens_hsa041421.91351964
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86665224
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80492636
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78318636
22Toxoplasmosis_Homo sapiens_hsa051451.74819052
23Influenza A_Homo sapiens_hsa051641.72146166
24* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69394094
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69377725
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57316208
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56587163
28Herpes simplex infection_Homo sapiens_hsa051681.56504070
29TNF signaling pathway_Homo sapiens_hsa046681.48827388
30Shigellosis_Homo sapiens_hsa051311.39295613
31Apoptosis_Homo sapiens_hsa042101.38662455
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.38203537
33* Chemokine signaling pathway_Homo sapiens_hsa040621.37711994
34Graft-versus-host disease_Homo sapiens_hsa053321.37697755
35Complement and coagulation cascades_Homo sapiens_hsa046101.36833190
36Salmonella infection_Homo sapiens_hsa051321.36567439
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.34417889
38Allograft rejection_Homo sapiens_hsa053301.26199828
39Caffeine metabolism_Homo sapiens_hsa002321.25715553
40Phagosome_Homo sapiens_hsa041451.23764937
41* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22601995
42Hepatitis B_Homo sapiens_hsa051611.22412982
43Asthma_Homo sapiens_hsa053101.16655216
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16414297
45African trypanosomiasis_Homo sapiens_hsa051431.12941714
46Rheumatoid arthritis_Homo sapiens_hsa053231.07918569
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05464591
48Viral myocarditis_Homo sapiens_hsa054161.01921347
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01192987
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00178452
51Chronic myeloid leukemia_Homo sapiens_hsa052200.99940448
52Hepatitis C_Homo sapiens_hsa051600.98122455
53Pancreatic cancer_Homo sapiens_hsa052120.97941131
54Acute myeloid leukemia_Homo sapiens_hsa052210.97834107
55* Platelet activation_Homo sapiens_hsa046110.96805829
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86825316
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85659573
58T cell receptor signaling pathway_Homo sapiens_hsa046600.84917688
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82958824
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82692692
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68607065
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.68522250
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68210596
64Amoebiasis_Homo sapiens_hsa051460.67093062
65* Epstein-Barr virus infection_Homo sapiens_hsa051690.66974824
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66256349
67Small cell lung cancer_Homo sapiens_hsa052220.64994928
68Dorso-ventral axis formation_Homo sapiens_hsa043200.62317358
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62236283
70ABC transporters_Homo sapiens_hsa020100.59787895
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59089734
72* Viral carcinogenesis_Homo sapiens_hsa052030.58140169
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55823240
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.49431532
75Systemic lupus erythematosus_Homo sapiens_hsa053220.47233529
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.45590079
77Insulin resistance_Homo sapiens_hsa049310.44685430
78Endometrial cancer_Homo sapiens_hsa052130.44573239
79Non-small cell lung cancer_Homo sapiens_hsa052230.44361053
80GnRH signaling pathway_Homo sapiens_hsa049120.44335002
81HIF-1 signaling pathway_Homo sapiens_hsa040660.44320966
82Renin-angiotensin system_Homo sapiens_hsa046140.44095206
83HTLV-I infection_Homo sapiens_hsa051660.43180092
84Prolactin signaling pathway_Homo sapiens_hsa049170.42236545
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42128938
86Type II diabetes mellitus_Homo sapiens_hsa049300.41762648
87mTOR signaling pathway_Homo sapiens_hsa041500.41376796
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.40558784
89Notch signaling pathway_Homo sapiens_hsa043300.40306508
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39868918
91VEGF signaling pathway_Homo sapiens_hsa043700.39516847
92Endocytosis_Homo sapiens_hsa041440.39373789
93Choline metabolism in cancer_Homo sapiens_hsa052310.39160088
94Prion diseases_Homo sapiens_hsa050200.37556963
95Bladder cancer_Homo sapiens_hsa052190.37484632
96MAPK signaling pathway_Homo sapiens_hsa040100.37299411
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37233457
98* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36561182
99Type I diabetes mellitus_Homo sapiens_hsa049400.35102682
100Prostate cancer_Homo sapiens_hsa052150.34353303
101Autoimmune thyroid disease_Homo sapiens_hsa053200.33974133
102Inositol phosphate metabolism_Homo sapiens_hsa005620.33606156
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32201648
104Proteoglycans in cancer_Homo sapiens_hsa052050.31816230
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31552462
106FoxO signaling pathway_Homo sapiens_hsa040680.31004185
107ErbB signaling pathway_Homo sapiens_hsa040120.29996393
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29459119
109p53 signaling pathway_Homo sapiens_hsa041150.27921099
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26998138
111MicroRNAs in cancer_Homo sapiens_hsa052060.26672807
112Pentose phosphate pathway_Homo sapiens_hsa000300.25547726
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24987055
114Colorectal cancer_Homo sapiens_hsa052100.22826242
115Rap1 signaling pathway_Homo sapiens_hsa040150.22677712
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22457523
117Base excision repair_Homo sapiens_hsa034100.21179573
118Renal cell carcinoma_Homo sapiens_hsa052110.19142688
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.18148879
120Adherens junction_Homo sapiens_hsa045200.16905066

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