LYPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.23473774
2axonemal dynein complex assembly (GO:0070286)8.69236391
3uronic acid metabolic process (GO:0006063)7.85253111
4glucuronate metabolic process (GO:0019585)7.85253111
5epidermal cell differentiation (GO:0009913)7.68854682
6L-ascorbic acid metabolic process (GO:0019852)7.54058614
7one-carbon compound transport (GO:0019755)7.42052817
8positive regulation of chemokine secretion (GO:0090197)7.22939127
9cellular glucuronidation (GO:0052695)7.09717247
10regulation of skeletal muscle contraction (GO:0014819)6.90730457
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.73930670
12glutathione derivative metabolic process (GO:1901685)6.73534552
13glutathione derivative biosynthetic process (GO:1901687)6.73534552
14cilium or flagellum-dependent cell motility (GO:0001539)6.72955008
15ethanol oxidation (GO:0006069)6.69852591
16establishment of skin barrier (GO:0061436)6.48666931
17apical protein localization (GO:0045176)6.28291263
18renal absorption (GO:0070293)6.05022676
19motile cilium assembly (GO:0044458)5.99715547
20desmosome organization (GO:0002934)5.97014532
21regulation of water loss via skin (GO:0033561)5.86248440
22cilium movement (GO:0003341)5.84363788
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.82455652
24lipoxygenase pathway (GO:0019372)5.48585386
25primary alcohol catabolic process (GO:0034310)5.46201165
26negative regulation of bone mineralization (GO:0030502)5.38257958
27phenylpropanoid metabolic process (GO:0009698)5.35668747
28O-glycan processing (GO:0016266)5.29415088
29negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)5.17136747
30negative regulation of homotypic cell-cell adhesion (GO:0034111)5.12465934
31ethanol metabolic process (GO:0006067)4.91420025
32epithelial cilium movement (GO:0003351)4.82984654
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.80106511
34epidermis development (GO:0008544)4.80009114
35water homeostasis (GO:0030104)4.74264180
36glutathione metabolic process (GO:0006749)4.73520126
37negative regulation of biomineral tissue development (GO:0070168)4.73288011
38establishment of apical/basal cell polarity (GO:0035089)4.72873857
39diterpenoid biosynthetic process (GO:0016102)4.66109877
40pinocytosis (GO:0006907)4.65781373
41proline biosynthetic process (GO:0006561)4.64743166
42sulfur amino acid catabolic process (GO:0000098)4.62725776
43long-chain fatty acid biosynthetic process (GO:0042759)4.51225036
44benzene-containing compound metabolic process (GO:0042537)4.47406099
45membrane raft organization (GO:0031579)4.45981460
46asymmetric protein localization (GO:0008105)4.38574014
47negative regulation of interleukin-17 production (GO:0032700)4.37179706
48hair cell differentiation (GO:0035315)4.28973711
49negative regulation of chondrocyte differentiation (GO:0032331)4.23796681
50regulation of female gonad development (GO:2000194)4.22810603
51establishment or maintenance of monopolar cell polarity (GO:0061339)4.11499040
52establishment of monopolar cell polarity (GO:0061162)4.11499040
53regulation of cardioblast proliferation (GO:0003264)4.11139610
54regulation of secondary heart field cardioblast proliferation (GO:0003266)4.11139610
55localization within membrane (GO:0051668)4.10471121
56hypotonic response (GO:0006971)3.94626781
57face development (GO:0060324)3.89273109
58positive regulation of interleukin-8 secretion (GO:2000484)3.88900732
59negative regulation of epidermal cell differentiation (GO:0045605)3.88302970
60superoxide anion generation (GO:0042554)3.86410627
61surfactant homeostasis (GO:0043129)3.84212568
62bone remodeling (GO:0046849)3.75698650
63myoblast migration (GO:0051451)3.74703315
64regulation of cholesterol biosynthetic process (GO:0045540)3.72874510
65relaxation of cardiac muscle (GO:0055119)3.72749096
66positive regulation of tolerance induction (GO:0002645)3.72633408
67left/right pattern formation (GO:0060972)3.63588338
68interleukin-6-mediated signaling pathway (GO:0070102)3.60250668
69regulation of platelet aggregation (GO:0090330)3.59390770
70generation of neurons (GO:0048699)3.58601685
71positive regulation of antigen processing and presentation (GO:0002579)3.57989015
72regulation of interleukin-8 secretion (GO:2000482)3.55607370
73sulfate transmembrane transport (GO:1902358)3.53572959
74detection of bacterium (GO:0016045)3.51600218
75axoneme assembly (GO:0035082)3.50495166
76cellular response to zinc ion (GO:0071294)3.47375561
77regulation of T cell migration (GO:2000404)3.46204379
78protein O-linked glycosylation (GO:0006493)3.45231166
79proline metabolic process (GO:0006560)3.42035572
80bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41827226
81negative regulation of interferon-gamma production (GO:0032689)3.41320841
82pharyngeal system development (GO:0060037)3.40824322
83transcription from mitochondrial promoter (GO:0006390)3.40098427
84regulation of keratinocyte proliferation (GO:0010837)3.39326989
85phospholipid scrambling (GO:0017121)3.36652988
86keratinocyte proliferation (GO:0043616)3.35945828
87polyol transport (GO:0015791)3.31052150
88regulation of antigen processing and presentation (GO:0002577)3.30276856
89interferon-gamma secretion (GO:0072643)3.28016944
90regulation of keratinocyte differentiation (GO:0045616)3.27147490
91neuron fate specification (GO:0048665)3.24912661
92regulation of interleukin-17 production (GO:0032660)3.23731725
93negative regulation of cartilage development (GO:0061037)3.22766360
94cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.22462155
95hormone catabolic process (GO:0042447)3.21228917
96negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.20996877
97detection of other organism (GO:0098543)3.18563839
98positive regulation of steroid biosynthetic process (GO:0010893)3.18179451
99citrulline biosynthetic process (GO:0019240)3.16696495
100oxidative demethylation (GO:0070989)3.16596799
101regulation of tolerance induction (GO:0002643)3.14728361
102gas transport (GO:0015669)3.12598026
103negative regulation of epidermis development (GO:0045683)3.11831133
104regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.11081590
105transepithelial transport (GO:0070633)3.10665155
106macrophage activation involved in immune response (GO:0002281)3.10084175
107Notch signaling involved in heart development (GO:0061314)3.09837032
108cell differentiation involved in metanephros development (GO:0072202)3.09170120
109xenobiotic metabolic process (GO:0006805)3.08478967
110energy homeostasis (GO:0097009)3.07921533
111chemical homeostasis within a tissue (GO:0048875)3.04068261
112nucleotide transmembrane transport (GO:1901679)3.04004910
113branching involved in salivary gland morphogenesis (GO:0060445)3.03416218
114positive regulation of protein homooligomerization (GO:0032464)3.02835111
115aorta morphogenesis (GO:0035909)3.02272853
116multicellular organismal water homeostasis (GO:0050891)3.00694486
117linoleic acid metabolic process (GO:0043651)3.00027943
118regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98900134
119epithelial cell differentiation (GO:0030855)2.98732620
120terpenoid biosynthetic process (GO:0016114)2.97821465
121negative regulation of cell-cell adhesion (GO:0022408)2.97636536
122positive regulation of interleukin-10 production (GO:0032733)2.96358509
123positive regulation of receptor recycling (GO:0001921)2.96047605
124regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.95755164
125regulation of mitochondrial depolarization (GO:0051900)2.93103966
126purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.92536992
1273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.92536992
128sulfate transport (GO:0008272)2.92052663
129establishment of planar polarity (GO:0001736)2.89389988
130establishment of tissue polarity (GO:0007164)2.89389988
131auditory receptor cell stereocilium organization (GO:0060088)2.89068079
132tolerance induction (GO:0002507)2.85470795
133response to caffeine (GO:0031000)2.85232144
134regulation of cell proliferation involved in kidney development (GO:1901722)2.84367923
135regulation of podosome assembly (GO:0071801)2.84218670
136regulation of ruffle assembly (GO:1900027)2.83666832
137intestinal epithelial cell development (GO:0060576)2.83453810
138positive regulation of endothelial cell differentiation (GO:0045603)2.83207700
139positive regulation of interleukin-1 beta secretion (GO:0050718)2.81436348
140pentose metabolic process (GO:0019321)2.81007416
141DNA double-strand break processing (GO:0000729)2.80712254
142ventricular system development (GO:0021591)2.79103562
143keratinocyte development (GO:0003334)2.78802795
144negative regulation of fatty acid transport (GO:2000192)2.77960201
145galactose metabolic process (GO:0006012)2.77294560
146regulation of type 2 immune response (GO:0002828)2.77197931
147regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74911024
148positive regulation of actin filament depolymerization (GO:0030836)2.74262959
149negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73882889
150regulation of interleukin-13 production (GO:0032656)2.73641368
151regulation of chemokine secretion (GO:0090196)2.73342234
152myeloid cell activation involved in immune response (GO:0002275)2.72663876
153regulation of hypersensitivity (GO:0002883)2.71563345
154regulation of glomerular filtration (GO:0003093)2.70793989
155embryonic process involved in female pregnancy (GO:0060136)2.70502621
156retinoic acid metabolic process (GO:0042573)2.69680767
157metanephric mesenchyme development (GO:0072075)2.69645744
158positive regulation of interleukin-1 secretion (GO:0050716)2.69040846
159viral mRNA export from host cell nucleus (GO:0046784)2.67110286
160camera-type eye morphogenesis (GO:0048593)2.66074931
161prostanoid metabolic process (GO:0006692)2.65878068
162prostaglandin metabolic process (GO:0006693)2.65878068
163negative regulation of response to cytokine stimulus (GO:0060761)2.65503110
164retinol metabolic process (GO:0042572)2.65351599
165relaxation of muscle (GO:0090075)2.64888287
166replication fork processing (GO:0031297)2.63872077
167negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.63263050
168DNA deamination (GO:0045006)2.62232840
169positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.59987694
170positive regulation of interleukin-1 beta production (GO:0032731)2.59880475
171defense response to Gram-negative bacterium (GO:0050829)2.59684072
172outer ear morphogenesis (GO:0042473)2.58179025
173nucleotide-sugar biosynthetic process (GO:0009226)2.58147720
174positive regulation of cation channel activity (GO:2001259)2.57648065
175regulation of interferon-beta biosynthetic process (GO:0045357)2.55306349
176norepinephrine metabolic process (GO:0042415)2.54624727
177neutrophil activation involved in immune response (GO:0002283)2.54590710
178left/right axis specification (GO:0070986)2.54096134
179positive regulation of chemokine biosynthetic process (GO:0045080)2.52952224
180positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.49581178
181regulation of interleukin-5 production (GO:0032674)2.46948418
182wound healing (GO:0042060)2.46741106
183regulation of interleukin-1 beta secretion (GO:0050706)2.44562729
184regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.41439678
185negative regulation of interleukin-6 production (GO:0032715)2.41183371
186hair follicle morphogenesis (GO:0031069)2.38627145
187keratinization (GO:0031424)14.8584954
188xenobiotic catabolic process (GO:0042178)12.5306612
189peptide cross-linking (GO:0018149)11.1427908
190response to nitrosative stress (GO:0051409)11.0091054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.69527853
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.56268345
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95818756
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.72223785
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.68211020
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.02677374
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.95418424
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.95418424
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.95418424
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.88889769
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.82023039
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.70472338
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.57601535
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34899545
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.32156412
16ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human2.24512777
17ZNF263_19887448_ChIP-Seq_K562_Human2.20999601
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15661846
19* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.08961697
20ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06094242
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02848914
22SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.00541413
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.96254442
24SOX2_18555785_ChIP-Seq_MESCs_Mouse1.95733753
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.90059038
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82404525
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76398608
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76299487
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72134932
30AHR_22903824_ChIP-Seq_MCF-7_Human1.70238738
31CLOCK_20551151_ChIP-Seq_293T_Human1.69935175
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68342596
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.64642044
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.54460430
35* SMC4_20622854_ChIP-Seq_HELA_Human1.53387475
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.50917553
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49790308
38TP63_22573176_ChIP-Seq_HFKS_Human1.49736692
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49327185
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49327185
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.49023030
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.47374290
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46773783
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46466982
45CTCF_27219007_Chip-Seq_Bcells_Human1.46018921
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45263859
47RACK7_27058665_Chip-Seq_MCF-7_Human1.43672457
48GATA1_19941826_ChIP-Seq_K562_Human1.43495221
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43479864
50SOX2_20726797_ChIP-Seq_SW620_Human1.41635643
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41477463
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.41077056
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40744105
54ATF3_27146783_Chip-Seq_COLON_Human1.37771758
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36368911
56SOX2_18692474_ChIP-Seq_MEFs_Mouse1.36235413
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36220123
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34962862
59KLF5_25053715_ChIP-Seq_YYC3_Human1.34309427
60LXR_22292898_ChIP-Seq_THP-1_Human1.33962521
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33793746
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32078977
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32068150
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32068150
65SPI1_23127762_ChIP-Seq_K562_Human1.32055358
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30589610
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29189510
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27753670
69POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27200742
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26050532
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26006267
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25117228
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.24766670
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24704394
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.23836573
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22961048
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.22600810
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.19839925
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19807743
80TP63_23658742_ChIP-Seq_EP156T_Human1.19742586
81TP53_18474530_ChIP-ChIP_U2OS_Human1.19629129
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.19553586
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18109052
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17391337
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17011346
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16591897
87NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16264181
88* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15911241
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15050896
90VDR_22108803_ChIP-Seq_LS180_Human1.14672935
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.12978843
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.12876930
93CTCF_20526341_ChIP-Seq_ESCs_Human1.12148104
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11819385
95ERG_20517297_ChIP-Seq_VCAP_Human1.10473009
96GATA6_21074721_ChIP-Seq_CACO-2_Human1.10448463
97P68_20966046_ChIP-Seq_HELA_Human1.09316390
98E2F1_20622854_ChIP-Seq_HELA_Human1.09037794
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.08946503
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08881613
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08821695
102VDR_24763502_ChIP-Seq_THP-1_Human1.08482793
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08377834
104BCL6_27268052_Chip-Seq_Bcells_Human1.08099879
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07707353
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.06918676
107BCOR_27268052_Chip-Seq_Bcells_Human1.05305691
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05263855
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04583273
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04518677
111GATA2_19941826_ChIP-Seq_K562_Human1.03032802
112TCF7_22412390_ChIP-Seq_EML_Mouse1.02290809
113TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00624164
114GATA6_25053715_ChIP-Seq_YYC3_Human1.00246332
115IRF8_22096565_ChIP-ChIP_GC-B_Human1.00124209
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00001984
117CREB1_26743006_Chip-Seq_LNCaP_Human0.98147819
118ELF5_23300383_ChIP-Seq_T47D_Human0.96533287
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96158933
120SA1_27219007_Chip-Seq_Bcells_Human0.95835268
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95767815
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95208289
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.95045740
124PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94773055
125NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94681592
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.94399156
127GATA4_25053715_ChIP-Seq_YYC3_Human0.94237487
128PHF8_20622854_ChIP-Seq_HELA_Human0.93802196
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93253530
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.92938887
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92712774
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92397467
133TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92057988
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.90305145
135SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88933082
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88058832
137GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87850085
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87713424
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87487139
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87261553
141CJUN_26792858_Chip-Seq_BT549_Human0.86918678
142SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86489758
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86460805
144RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86395925
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86385897
146RUNX_20019798_ChIP-Seq_JUKART_Human0.85777726
147OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85555670
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84928390
149CEBPB_22108803_ChIP-Seq_LS180_Human0.84884876
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84628757
151IRF8_21731497_ChIP-ChIP_J774_Mouse0.84336838
152POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84112000
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83699506
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83651059
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82745743
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.82177330
157STAT1_20625510_ChIP-Seq_HELA_Human0.81838587
158EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81290456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology5.91084239
2MP0008875_abnormal_xenobiotic_pharmacok5.48915211
3MP0008789_abnormal_olfactory_epithelium5.36478381
4MP0005394_taste/olfaction_phenotype4.74113440
5MP0005499_abnormal_olfactory_system4.74113440
6MP0005275_abnormal_skin_tensile4.32505193
7MP0005501_abnormal_skin_physiology3.72056610
8MP0010678_abnormal_skin_adnexa3.31472874
9MP0002132_abnormal_respiratory_system3.19110534
10MP0001346_abnormal_lacrimal_gland3.18386693
11MP0005083_abnormal_biliary_tract3.07508877
12MP0003186_abnormal_redox_activity2.74418819
13MP0002877_abnormal_melanocyte_morpholog2.72515725
14MP0000762_abnormal_tongue_morphology2.54206502
15MP0008995_early_reproductive_senescence2.39616624
16MP0009278_abnormal_bone_marrow2.18400050
17MP0001984_abnormal_olfaction2.12008152
18MP0002254_reproductive_system_inflammat2.09674854
19MP0000678_abnormal_parathyroid_gland2.09406097
20MP0009780_abnormal_chondrocyte_physiolo2.00374368
21MP0010234_abnormal_vibrissa_follicle11.7143834
22MP0002009_preneoplasia1.99190451
23MP0005171_absent_coat_pigmentation1.95878565
24MP0004043_abnormal_pH_regulation1.92692532
25MP0003786_premature_aging1.92206783
26MP0003941_abnormal_skin_development1.88260971
27MP0000566_synostosis1.82159083
28MP0005248_abnormal_Harderian_gland1.79402250
29MP0002653_abnormal_ependyma_morphology1.78708149
30MP0004264_abnormal_extraembryonic_tissu1.77308583
31MP0002233_abnormal_nose_morphology1.76901205
32MP0002249_abnormal_larynx_morphology1.76794800
33MP0004019_abnormal_vitamin_homeostasis1.71057989
34MP0010771_integument_phenotype1.67119408
35MP0003453_abnormal_keratinocyte_physiol1.66217369
36MP0000465_gastrointestinal_hemorrhage1.63705042
37MP0004185_abnormal_adipocyte_glucose1.61134560
38MP0000049_abnormal_middle_ear1.60672491
39MP0000613_abnormal_salivary_gland1.56795610
40MP0010368_abnormal_lymphatic_system1.54149745
41MP0009053_abnormal_anal_canal1.51891934
42MP0003724_increased_susceptibility_to1.44714722
43MP0001545_abnormal_hematopoietic_system1.43539885
44MP0005397_hematopoietic_system_phenotyp1.43539885
45MP0004233_abnormal_muscle_weight1.41466406
46MP0006292_abnormal_olfactory_placode1.36990024
47MP0005503_abnormal_tendon_morphology1.36853907
48MP0003828_pulmonary_edema1.36844113
49MP0004885_abnormal_endolymph1.36784342
50MP0008057_abnormal_DNA_replication1.36434620
51MP0002098_abnormal_vibrissa_morphology1.36189229
52MP0008004_abnormal_stomach_pH1.35166666
53MP0004947_skin_inflammation1.32732542
54MP0003878_abnormal_ear_physiology1.21979857
55MP0005377_hearing/vestibular/ear_phenot1.21979857
56MP0001765_abnormal_ion_homeostasis1.21905847
57MP0002277_abnormal_respiratory_mucosa1.18966219
58MP0003890_abnormal_embryonic-extraembry1.18506953
59MP0000467_abnormal_esophagus_morphology1.17684330
60MP0005166_decreased_susceptibility_to1.13981831
61MP0000377_abnormal_hair_follicle1.11933454
62MP0009333_abnormal_splenocyte_physiolog1.11752995
63MP0001851_eye_inflammation1.11736468
64MP0005408_hypopigmentation1.11613028
65MP0004782_abnormal_surfactant_physiolog1.09737398
66MP0002148_abnormal_hypersensitivity_rea1.09729525
67MP0005365_abnormal_bile_salt1.08888204
68MP0005023_abnormal_wound_healing1.04491967
69MP0002060_abnormal_skin_morphology1.04048933
70MP0002295_abnormal_pulmonary_circulatio1.02725398
71MP0005464_abnormal_platelet_physiology1.02051512
72MP0005409_darkened_coat_color1.01084953
73MP0009379_abnormal_foot_pigmentation1.00334852
74MP0003566_abnormal_cell_adhesion1.00281866
75MP0000579_abnormal_nail_morphology0.99339028
76MP0004883_abnormal_blood_vessel0.97525084
77MP0005164_abnormal_response_to0.96932618
78MP0003279_aneurysm0.96574689
79MP0002933_joint_inflammation0.95653733
80MP0003755_abnormal_palate_morphology0.94425947
81MP0000534_abnormal_ureter_morphology0.94413971
82MP0002796_impaired_skin_barrier0.94315426
83MP0008872_abnormal_physiological_respon0.92524448
84MP0003690_abnormal_glial_cell0.90515992
85MP0005085_abnormal_gallbladder_physiolo0.89104714
86MP0003806_abnormal_nucleotide_metabolis0.88495561
87MP0005025_abnormal_response_to0.87981842
88MP0010155_abnormal_intestine_physiology0.87745484
89MP0010352_gastrointestinal_tract_polyps0.85571636
90MP0001340_abnormal_eyelid_morphology0.85160030
91MP0002095_abnormal_skin_pigmentation0.84913256
92MP0001542_abnormal_bone_strength0.83430549
93MP0009931_abnormal_skin_appearance0.81934158
94MP0005666_abnormal_adipose_tissue0.81180268
95MP0006082_CNS_inflammation0.80947728
96MP0005388_respiratory_system_phenotype0.80701020
97MP0002133_abnormal_respiratory_system0.80701020
98MP0003436_decreased_susceptibility_to0.80524489
99MP0003075_altered_response_to0.79900184
100MP0002282_abnormal_trachea_morphology0.79759252
101MP0005508_abnormal_skeleton_morphology0.79111829
102MP0009250_abnormal_appendicular_skeleto0.77373751
103MP0000681_abnormal_thyroid_gland0.76174469
104MP0001835_abnormal_antigen_presentation0.74349541
105MP0002405_respiratory_system_inflammati0.73348174
106MP0001186_pigmentation_phenotype0.73288893
107MP0005670_abnormal_white_adipose0.73196425
108MP0006072_abnormal_retinal_apoptosis0.72659425
109MP0000858_altered_metastatic_potential0.72292764
110MP0003385_abnormal_body_wall0.72005671
111MP0001501_abnormal_sleep_pattern0.71322133
112MP0001905_abnormal_dopamine_level0.70823242
113MP0005266_abnormal_metabolism0.70785985
114MP0005646_abnormal_pituitary_gland0.70098353
115MP0003942_abnormal_urinary_system0.70075269
116MP0003937_abnormal_limbs/digits/tail_de0.70070673
117MP0002419_abnormal_innate_immunity0.68542886
118MP0003011_delayed_dark_adaptation0.67423686
119MP0003705_abnormal_hypodermis_morpholog0.67209849
120MP0002111_abnormal_tail_morphology0.65877516
121MP0000371_diluted_coat_color0.65750927
122MP0009785_altered_susceptibility_to0.65127703
123MP0000470_abnormal_stomach_morphology0.64305310
124MP0000367_abnormal_coat/_hair0.64259262
125MP0003136_yellow_coat_color0.63544416
126MP0003303_peritoneal_inflammation0.63495667
127MP0009115_abnormal_fat_cell0.60539244
128MP0005636_abnormal_mineral_homeostasis0.60126263
129MP0000477_abnormal_intestine_morphology0.60049497
130MP0002136_abnormal_kidney_physiology0.59969840
131MP0003936_abnormal_reproductive_system0.59189157
132MP0000383_abnormal_hair_follicle0.58619657
133MP0001533_abnormal_skeleton_physiology0.58246804
134MP0002116_abnormal_craniofacial_bone0.57539848
135MP0003938_abnormal_ear_development0.56616098
136MP0001919_abnormal_reproductive_system0.55920766
137MP0001216_abnormal_epidermal_layer0.55861504
138MP0001502_abnormal_circadian_rhythm0.54899240
139MP0002332_abnormal_exercise_endurance0.54785009
140MP0001663_abnormal_digestive_system0.54471818
141MP0001958_emphysema0.53664229
142MP0003935_abnormal_craniofacial_develop0.53644240
143MP0002177_abnormal_outer_ear0.53342961
144MP0003638_abnormal_response/metabolism_0.53207035
145MP0001790_abnormal_immune_system0.52724401
146MP0005387_immune_system_phenotype0.52724401
147MP0001784_abnormal_fluid_regulation0.52696700
148MP0003183_abnormal_peptide_metabolism0.52450941
149MP0002166_altered_tumor_susceptibility0.52333036
150MP0002234_abnormal_pharynx_morphology0.50892632
151MP0000537_abnormal_urethra_morphology0.50747830
152MP0001243_abnormal_dermal_layer0.50416971
153MP0005076_abnormal_cell_differentiation0.50170022
154MP0002092_abnormal_eye_morphology0.50014679
155MP0001873_stomach_inflammation0.49591776
156MP0009643_abnormal_urine_homeostasis0.48489014
157MP0001756_abnormal_urination0.45958330
158MP0001664_abnormal_digestion0.45197836
159MP0001270_distended_abdomen0.43759024

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.43996586
2Absent/shortened dynein arms (HP:0200106)8.43996586
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.61696680
4Abnormal respiratory motile cilium physiology (HP:0012261)7.29775076
5Abnormal ciliary motility (HP:0012262)7.27964148
6Nasal polyposis (HP:0100582)7.25286404
7Chronic bronchitis (HP:0004469)7.04036462
8Oral leukoplakia (HP:0002745)6.39510717
9Increased IgE level (HP:0003212)6.36880328
10Abnormality of the nasal mucosa (HP:0000433)6.08475024
11Rhinitis (HP:0012384)5.97524654
12Lip pit (HP:0100267)5.26502660
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.25210516
14Stomach cancer (HP:0012126)5.03191707
15Abnormal hemoglobin (HP:0011902)4.91845197
16Congenital ichthyosiform erythroderma (HP:0007431)4.85799977
17Bronchiectasis (HP:0002110)4.78879535
18Nonprogressive disorder (HP:0003680)4.71285244
19Erythroderma (HP:0001019)4.67737164
20Fragile nails (HP:0001808)4.47237114
21Distal lower limb muscle weakness (HP:0009053)4.40301560
22Alopecia of scalp (HP:0002293)4.33652055
23Palmoplantar hyperkeratosis (HP:0000972)4.10004819
24Palmar hyperkeratosis (HP:0010765)3.99944584
25Hyperactive renin-angiotensin system (HP:0000841)3.99682651
26Plantar hyperkeratosis (HP:0007556)3.97347690
27Ulnar bowing (HP:0003031)3.85795180
28Bronchitis (HP:0012387)3.61897888
29Abnormality of small intestinal villus morphology (HP:0011472)3.61470657
30Villous atrophy (HP:0011473)3.61470657
31Pustule (HP:0200039)3.54736244
32Recurrent sinusitis (HP:0011108)3.38421697
33Vaginal fistula (HP:0004320)3.34507645
34Bifid scrotum (HP:0000048)3.33851003
35Abnormality of nail color (HP:0100643)3.27916840
36Popliteal pterygium (HP:0009756)3.26381514
37Turricephaly (HP:0000262)3.25992714
38Parakeratosis (HP:0001036)3.19024811
39Erythema (HP:0010783)3.17812966
40Humeroradial synostosis (HP:0003041)3.15090110
41Synostosis involving the elbow (HP:0003938)3.15090110
42Hyperkalemia (HP:0002153)3.13597792
43Down-sloping shoulders (HP:0200021)3.04964485
44Right ventricular cardiomyopathy (HP:0011663)3.02180624
45Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.00637314
46Stenosis of the external auditory canal (HP:0000402)2.97885884
47Prostate neoplasm (HP:0100787)2.97613219
48Choanal stenosis (HP:0000452)2.93162653
49Renal salt wasting (HP:0000127)2.92754922
50Abnormality of the distal phalanges of the toes (HP:0010182)2.92682997
51Median cleft lip (HP:0000161)2.92171627
52Cheilitis (HP:0100825)2.91359184
53Recurrent otitis media (HP:0000403)2.90171196
54Acanthosis nigricans (HP:0000956)2.88852834
55Annular pancreas (HP:0001734)2.87932704
56Bronchomalacia (HP:0002780)2.87778986
57Urethral obstruction (HP:0000796)2.83217228
58Sparse scalp hair (HP:0002209)2.82995987
59Onycholysis (HP:0001806)2.82116943
60Pulmonary artery stenosis (HP:0004415)2.80564486
61Decreased circulating renin level (HP:0003351)2.79011702
62Bowed forearm bones (HP:0003956)2.73736707
63Bowing of the arm (HP:0006488)2.73736707
64Abnormality of the nasal septum (HP:0000419)2.72252417
65Polycythemia (HP:0001901)2.68705826
66Furrowed tongue (HP:0000221)2.65236250
67Eczematoid dermatitis (HP:0000976)2.62097377
68Aplasia involving bones of the extremities (HP:0009825)2.61494749
69Aplasia involving bones of the upper limbs (HP:0009823)2.61494749
70Aplasia of the phalanges of the hand (HP:0009802)2.61494749
71Brittle hair (HP:0002299)2.60359344
72Neonatal hypoglycemia (HP:0001998)2.58162918
73Bifid uvula (HP:0000193)2.50791376
74Chronic sinusitis (HP:0011109)2.49527751
75Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.49017773
76Abnormality of the phalanges of the 2nd finger (HP:0009541)2.45222938
77Abnormality of the middle phalanges of the toes (HP:0010183)2.45023416
78Renal tubular acidosis (HP:0001947)2.37166376
79Infertility (HP:0000789)2.34071510
80Urticaria (HP:0001025)2.32449621
81Fragile skin (HP:0001030)2.31190396
82Preauricular pit (HP:0004467)2.29623321
83Periauricular skin pits (HP:0100277)2.29623321
84Osteomalacia (HP:0002749)2.28736429
85Abnormality of renin-angiotensin system (HP:0000847)2.27272767
86Abnormality of chloride homeostasis (HP:0011422)2.22707997
87Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.21122817
88Nail dystrophy (HP:0008404)2.21021104
89Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.20331762
90Vertebral hypoplasia (HP:0008417)2.20331762
91Corneal erosion (HP:0200020)2.20130006
92Abnormal respiratory motile cilium morphology (HP:0005938)2.19065056
93Abnormal respiratory epithelium morphology (HP:0012253)2.19065056
94Hyperaldosteronism (HP:0000859)2.19049630
95Abnormality of male internal genitalia (HP:0000022)2.18872781
96Esophageal atresia (HP:0002032)2.18807845
97Gastrointestinal atresia (HP:0002589)2.18340108
98Male infertility (HP:0003251)2.18184182
99Rib fusion (HP:0000902)2.15332089
100Dehydration (HP:0001944)2.15268745
101Aplasia/Hypoplasia of the fovea (HP:0008060)2.14992744
102Hypoplasia of the fovea (HP:0007750)2.14992744
103Steatorrhea (HP:0002570)2.14769804
104Carpal synostosis (HP:0009702)2.14322523
105Hypergammaglobulinemia (HP:0010702)2.13055549
106Cupped ear (HP:0000378)2.12806483
107Concave nail (HP:0001598)2.12188853
108Oligodontia (HP:0000677)2.09260804
109Dysautonomia (HP:0002459)2.07070758
110Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.06342030
111Diaphragmatic weakness (HP:0009113)2.06296820
112Short nail (HP:0001799)2.04815770
113Woolly hair (HP:0002224)2.04626954
114Choroideremia (HP:0001139)2.04537593
115Growth hormone excess (HP:0000845)2.02820068
116Short hallux (HP:0010109)2.02291128
117Chronic hepatic failure (HP:0100626)1.98245188
118Recurrent bacterial skin infections (HP:0005406)1.98031878
119Alveolar cell carcinoma (HP:0006519)1.97722945
120Narrow nasal bridge (HP:0000446)1.96865502
121Submucous cleft hard palate (HP:0000176)1.96584087
122Increased IgM level (HP:0003496)1.95930380
123Increased circulating renin level (HP:0000848)1.95495903
124Abnormality of polysaccharide metabolism (HP:0011012)1.92433744
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92433744
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92433744
127Hemivertebrae (HP:0002937)1.90856270
128Abnormality of the salivary glands (HP:0010286)1.89126486
129Progressive sensorineural hearing impairment (HP:0000408)1.89030730
130Autoamputation (HP:0001218)1.88552518
131Morphological abnormality of the middle ear (HP:0008609)1.87399637
132Split foot (HP:0001839)1.87078426
133Abnormality of the phalanges of the 5th finger (HP:0004213)1.85480335
134Chronic otitis media (HP:0000389)1.85474152
135Aplasia/Hypoplasia of the scapulae (HP:0006713)1.84946349
136Hypoplastic scapulae (HP:0000882)1.84946349
137Hypoplasia of the ulna (HP:0003022)1.84785057
138Tarsal synostosis (HP:0008368)1.84079603
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.83533766
140Hypokalemic alkalosis (HP:0001949)1.82550087
141Spinal muscular atrophy (HP:0007269)1.82013116
142Aplasia/Hypoplasia of the hallux (HP:0008362)1.81420723
143Palpitations (HP:0001962)1.81164232
144Chorioretinal atrophy (HP:0000533)1.81147900
145Nasolacrimal duct obstruction (HP:0000579)1.81083691
146Anophthalmia (HP:0000528)1.80983446
147Hyponatremia (HP:0002902)1.80787957
148Obstructive sleep apnea (HP:0002870)1.80190475
149Sleep apnea (HP:0010535)1.80068760
150Milia (HP:0001056)1.79943621
151Abnormality of the lacrimal duct (HP:0011481)1.79117415
152Flat acetabular roof (HP:0003180)1.78908273
153Hypotrichosis (HP:0001006)1.78868299
154Interstitial pulmonary disease (HP:0006530)1.78032014
155Synostosis involving bones of the hand (HP:0004278)1.76473820
156Corneal dystrophy (HP:0001131)1.72433178
157Tubulointerstitial nephritis (HP:0001970)1.68694327
158Malnutrition (HP:0004395)1.68582707
159Papilloma (HP:0012740)1.68276678
160Verrucae (HP:0200043)1.68276678
161Abnormal blistering of the skin (HP:0008066)1.66797029
162Ectropion (HP:0000656)1.65350488
163Hypoplastic labia majora (HP:0000059)1.64351220
164Hoarse voice (HP:0001609)1.60486976
165Atelectasis (HP:0100750)1.58045513
166Emphysema (HP:0002097)1.51761319
167Labial hypoplasia (HP:0000066)1.51007908
168Abnormality of the labia majora (HP:0012881)1.50704994
169Delusions (HP:0000746)1.50273467
170Absent eyelashes (HP:0000561)1.49789663
171Nephropathy (HP:0000112)1.45980348
172Elevated erythrocyte sedimentation rate (HP:0003565)1.44701694
173Recurrent corneal erosions (HP:0000495)1.42436083
174Occipital encephalocele (HP:0002085)1.40138565
175Arterial tortuosity (HP:0005116)1.38420528
176Abnormal pancreas size (HP:0012094)1.38226781
177Tubular atrophy (HP:0000092)1.36557553
178Hypoplastic female external genitalia (HP:0012815)1.34836576
179Adrenal overactivity (HP:0002717)1.33663040
180Hypotension (HP:0002615)1.31655736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.67542422
2MAP3K94.03483092
3ERBB33.41001168
4MST43.39934195
5RIPK42.95044080
6TRPM72.81538975
7MAP3K32.77609885
8ZAP702.73294752
9RPS6KB22.61630915
10MAP3K112.50202017
11SIK32.35733650
12PBK2.32411744
13HIPK22.24965990
14DDR22.22410880
15NME12.20239059
16EPHA22.17745672
17EPHB22.15410367
18KSR22.13524313
19ZAK1.98584242
20MAP2K31.90488002
21PINK11.83912733
22CDK61.83719570
23ARAF1.79185860
24TYRO31.78644094
25RIPK11.73532334
26ICK1.73475562
27MAP3K61.72641603
28WNK11.72640007
29STK241.71272461
30SGK21.59726227
31TAOK11.58798172
32TAOK21.56664366
33GRK61.54063928
34TBK11.50827351
35MAP3K131.47315138
36SGK31.47021307
37ADRBK21.43926013
38STK38L1.39648310
39MARK21.34062688
40BMPR21.33716325
41SGK2231.33145611
42SGK4941.33145611
43MAP3K21.29647291
44BMX1.28180584
45ERN11.27604697
46MATK1.25775841
47TESK11.25071814
48MAPKAPK31.24335986
49LRRK21.24266173
50EPHA31.21521709
51MAP2K21.20311278
52DAPK21.17919230
53MAP3K71.12401156
54MET1.10140361
55TLK11.08063980
56SIK11.06657495
57EPHB11.06148318
58RPS6KL11.05696085
59RPS6KC11.05696085
60IKBKE1.05523564
61TNIK1.00652669
62FRK0.97606559
63PIM20.97574851
64RPS6KA60.97470917
65STK100.95882853
66IRAK40.94495336
67DMPK0.94489513
68DAPK10.88902196
69CDK190.87313876
70PDK20.86901522
71FGR0.86605495
72IRAK20.84369940
73FER0.83756795
74GSK3A0.82753095
75LIMK10.80437282
76PDPK10.80345408
77BLK0.80053487
78DYRK1B0.79729927
79ACVR1B0.76573859
80CSK0.76501649
81RAF10.75943802
82MST1R0.73716530
83PRKD20.71345022
84STK390.70849574
85PRKCI0.69519725
86NEK60.69305841
87CAMK1D0.68698383
88NLK0.68635914
89KSR10.67735984
90MKNK20.67317012
91DYRK30.66886208
92IRAK10.66188021
93TAOK30.66099842
94WNK40.65529148
95MOS0.65403836
96BCKDK0.63227588
97CDK70.63185011
98IKBKB0.62234720
99RPS6KA20.60382697
100PRKG20.60136394
101MAPKAPK20.59796999
102MAP4K10.58662235
103CAMK2B0.58583298
104AKT30.57996310
105YES10.57871647
106LATS20.56529790
107CAMK2D0.55384371
108MAP2K10.53779211
109UHMK10.53143598
110PDGFRB0.52804143
111TGFBR20.51602945
112CSF1R0.49913204
113RPS6KA40.47376846
114CAMK2G0.46973311
115GRK50.45991795
116RPS6KA10.45225772
117MAP2K60.43907812
118SGK10.40989869
119BCR0.40061011
120PAK40.39564689
121STK40.39552098
122PIM10.39152295
123PHKG20.38981881
124PHKG10.38981881
125HCK0.38081593
126PRKCE0.37788740
127PDK10.37632392
128ERBB20.37557584
129PRKCD0.37205048
130PRKD10.37026121
131MAP3K120.36523750
132STK380.36300204
133TRIB30.35818751
134SIK20.35509087
135ABL20.34598093
136PTK2B0.33343125
137CDC42BPA0.33325594
138CAMK1G0.33044115
139LATS10.32503019
140MAPK70.29993607
141MAPK30.29992924
142CHUK0.28489004
143FYN0.28411094
144CAMK2A0.28159051
145MAP3K10.28083341
146MAPK10.27888660
147PTK20.27315786
148PAK10.27291433
149LYN0.25784115
150PTK60.25506463
151MYLK0.25241385
152PRKAA20.25217550
153PIK3CA0.24317990
154ATR0.23862539
155ALK0.22936762
156ITK0.22515222

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009806.33409027
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009826.28285331
3Chemical carcinogenesis_Homo sapiens_hsa052045.45169006
4Pentose and glucuronate interconversions_Homo sapiens_hsa000404.86334161
5Glutathione metabolism_Homo sapiens_hsa004803.72561508
6Sulfur metabolism_Homo sapiens_hsa009203.58891578
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16551811
8Sulfur relay system_Homo sapiens_hsa041223.14450624
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.31033650
10Phenylalanine metabolism_Homo sapiens_hsa003602.14560071
11Retinol metabolism_Homo sapiens_hsa008302.11322797
12Salivary secretion_Homo sapiens_hsa049702.07370969
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.98553559
14Tyrosine metabolism_Homo sapiens_hsa003501.96413789
15Histidine metabolism_Homo sapiens_hsa003401.81053884
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76864798
17Staphylococcus aureus infection_Homo sapiens_hsa051501.67162414
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62650643
19beta-Alanine metabolism_Homo sapiens_hsa004101.59853865
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.59415086
21Circadian rhythm_Homo sapiens_hsa047101.54304683
22Fatty acid biosynthesis_Homo sapiens_hsa000611.41948220
23Acute myeloid leukemia_Homo sapiens_hsa052211.35566647
24Starch and sucrose metabolism_Homo sapiens_hsa005001.35196175
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34189128
26Allograft rejection_Homo sapiens_hsa053301.33956466
27Influenza A_Homo sapiens_hsa051641.32743304
28Asthma_Homo sapiens_hsa053101.30919998
29Galactose metabolism_Homo sapiens_hsa000521.29752533
30Osteoclast differentiation_Homo sapiens_hsa043801.26153608
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.24943580
32Endocytosis_Homo sapiens_hsa041441.17800321
33Tuberculosis_Homo sapiens_hsa051521.17213496
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10527592
35Adherens junction_Homo sapiens_hsa045201.09901241
36Autoimmune thyroid disease_Homo sapiens_hsa053201.09882458
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03622642
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02313908
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02010586
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99516181
41Type I diabetes mellitus_Homo sapiens_hsa049400.96294065
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95794110
43Hippo signaling pathway_Homo sapiens_hsa043900.93385210
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92662217
45B cell receptor signaling pathway_Homo sapiens_hsa046620.90771505
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85179941
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.85056256
48Mineral absorption_Homo sapiens_hsa049780.80984571
49Sphingolipid metabolism_Homo sapiens_hsa006000.78879258
50Choline metabolism in cancer_Homo sapiens_hsa052310.77861636
51TGF-beta signaling pathway_Homo sapiens_hsa043500.77781376
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.76074484
53Tight junction_Homo sapiens_hsa045300.75085413
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74997398
55Linoleic acid metabolism_Homo sapiens_hsa005910.74665284
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73842678
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.72969883
58Chemokine signaling pathway_Homo sapiens_hsa040620.71564881
59VEGF signaling pathway_Homo sapiens_hsa043700.71036270
60Toxoplasmosis_Homo sapiens_hsa051450.67431887
61Platelet activation_Homo sapiens_hsa046110.67242660
62Notch signaling pathway_Homo sapiens_hsa043300.63757582
63Pancreatic cancer_Homo sapiens_hsa052120.63293130
64Renal cell carcinoma_Homo sapiens_hsa052110.62778742
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61336917
66Chronic myeloid leukemia_Homo sapiens_hsa052200.59645632
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57874075
68Rheumatoid arthritis_Homo sapiens_hsa053230.57431773
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55639855
70Long-term potentiation_Homo sapiens_hsa047200.54948150
71Fatty acid degradation_Homo sapiens_hsa000710.54309700
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50765011
73TNF signaling pathway_Homo sapiens_hsa046680.50691527
74Arginine and proline metabolism_Homo sapiens_hsa003300.50486611
75GnRH signaling pathway_Homo sapiens_hsa049120.50453778
76Hematopoietic cell lineage_Homo sapiens_hsa046400.50345956
77Gastric acid secretion_Homo sapiens_hsa049710.50183381
78Serotonergic synapse_Homo sapiens_hsa047260.50166000
79Insulin signaling pathway_Homo sapiens_hsa049100.50121896
80Endometrial cancer_Homo sapiens_hsa052130.49565417
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49192514
82Mismatch repair_Homo sapiens_hsa034300.48679538
83Antigen processing and presentation_Homo sapiens_hsa046120.48157887
84Herpes simplex infection_Homo sapiens_hsa051680.47887239
85Collecting duct acid secretion_Homo sapiens_hsa049660.47447219
86T cell receptor signaling pathway_Homo sapiens_hsa046600.47276689
87African trypanosomiasis_Homo sapiens_hsa051430.46893344
88Colorectal cancer_Homo sapiens_hsa052100.46545267
89Non-small cell lung cancer_Homo sapiens_hsa052230.46429317
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44642303
91Huntingtons disease_Homo sapiens_hsa050160.44307009
92Basal cell carcinoma_Homo sapiens_hsa052170.43432222
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.43111363
94Arachidonic acid metabolism_Homo sapiens_hsa005900.42760483
95Pertussis_Homo sapiens_hsa051330.42741856
96Bladder cancer_Homo sapiens_hsa052190.41271723
97Complement and coagulation cascades_Homo sapiens_hsa046100.40870776
98Graft-versus-host disease_Homo sapiens_hsa053320.39850377
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39502247
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39175133
101ABC transporters_Homo sapiens_hsa020100.38702907
102Steroid biosynthesis_Homo sapiens_hsa001000.38641505
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38358518
104Base excision repair_Homo sapiens_hsa034100.38007758
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.37552457
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36417551
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36185554
108Caffeine metabolism_Homo sapiens_hsa002320.33381215
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28318378
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26827531
111Peroxisome_Homo sapiens_hsa041460.26475399
112Prion diseases_Homo sapiens_hsa050200.24606613
113Legionellosis_Homo sapiens_hsa051340.23290361
114Prostate cancer_Homo sapiens_hsa052150.21192942
115Salmonella infection_Homo sapiens_hsa051320.20532589
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.19180509
117Wnt signaling pathway_Homo sapiens_hsa043100.18450041
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.17985052
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17778779
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17358621
121Proteoglycans in cancer_Homo sapiens_hsa052050.17307970
122Hedgehog signaling pathway_Homo sapiens_hsa043400.16215408
123Vibrio cholerae infection_Homo sapiens_hsa051100.16082226
124Fatty acid metabolism_Homo sapiens_hsa012120.15805012
125Folate biosynthesis_Homo sapiens_hsa007900.15315074
126Thyroid cancer_Homo sapiens_hsa052160.14776475
127Butanoate metabolism_Homo sapiens_hsa006500.14017202
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.13859832
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13622923
130Selenocompound metabolism_Homo sapiens_hsa004500.13466624
131Axon guidance_Homo sapiens_hsa043600.13289567
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13147766
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12520869
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12361574
135Phagosome_Homo sapiens_hsa041450.11345435
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10228630
137mRNA surveillance pathway_Homo sapiens_hsa030150.09949305
138Prolactin signaling pathway_Homo sapiens_hsa049170.08205028
139Pathways in cancer_Homo sapiens_hsa052000.07901590
140Leishmaniasis_Homo sapiens_hsa051400.07195944
141Shigellosis_Homo sapiens_hsa051310.06988173
142Small cell lung cancer_Homo sapiens_hsa052220.06579320
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05002992
144Viral myocarditis_Homo sapiens_hsa054160.04591190
145FoxO signaling pathway_Homo sapiens_hsa040680.04487913
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.03509532
147ECM-receptor interaction_Homo sapiens_hsa045120.03506119
148Malaria_Homo sapiens_hsa051440.02690133
149Hepatitis C_Homo sapiens_hsa051600.02083400
150Amoebiasis_Homo sapiens_hsa051460.01804040

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