

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | keratinocyte differentiation (GO:0030216) | 9.06013052 |
| 2 | hemidesmosome assembly (GO:0031581) | 8.60143684 |
| 3 | multicellular organismal water homeostasis (GO:0050891) | 7.92524537 |
| 4 | peptide cross-linking (GO:0018149) | 7.49416993 |
| 5 | epidermal cell differentiation (GO:0009913) | 6.97352560 |
| 6 | intermediate filament organization (GO:0045109) | 6.94249967 |
| 7 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 6.92042231 |
| 8 | keratinocyte proliferation (GO:0043616) | 6.79131130 |
| 9 | water homeostasis (GO:0030104) | 6.68667569 |
| 10 | sphingoid metabolic process (GO:0046519) | 6.28032396 |
| 11 | epidermis development (GO:0008544) | 6.23757112 |
| 12 | sphingosine metabolic process (GO:0006670) | 5.91023653 |
| 13 | keratinocyte development (GO:0003334) | 5.74430705 |
| 14 | skin morphogenesis (GO:0043589) | 5.33564117 |
| 15 | glucosamine-containing compound catabolic process (GO:1901072) | 5.31598119 |
| 16 | diol metabolic process (GO:0034311) | 5.30113527 |
| 17 | gap junction assembly (GO:0016264) | 5.28181888 |
| 18 | interferon-gamma secretion (GO:0072643) | 5.20399535 |
| 19 | long-chain fatty acid biosynthetic process (GO:0042759) | 5.10584473 |
| 20 | regulation of ruffle assembly (GO:1900027) | 4.75176285 |
| 21 | fatty acid elongation (GO:0030497) | 4.73922728 |
| 22 | ectoderm development (GO:0007398) | 4.58268057 |
| 23 | surfactant homeostasis (GO:0043129) | 4.44072352 |
| 24 | intermediate filament cytoskeleton organization (GO:0045104) | 4.36335556 |
| 25 | polarized epithelial cell differentiation (GO:0030859) | 4.34455411 |
| 26 | regulation of phospholipase A2 activity (GO:0032429) | 4.33642326 |
| 27 | positive regulation of keratinocyte differentiation (GO:0045618) | 4.28513103 |
| 28 | intermediate filament-based process (GO:0045103) | 4.24403128 |
| 29 | regulation of chemokine secretion (GO:0090196) | 4.20390733 |
| 30 | regulation of natural killer cell differentiation (GO:0032823) | 4.08368473 |
| 31 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 4.01110852 |
| 32 | negative regulation of keratinocyte proliferation (GO:0010839) | 3.99793008 |
| 33 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 3.94115070 |
| 34 | negative regulation of stress fiber assembly (GO:0051497) | 3.90703322 |
| 35 | linoleic acid metabolic process (GO:0043651) | 3.74178442 |
| 36 | detection of bacterium (GO:0016045) | 3.71955908 |
| 37 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.70123472 |
| 38 | chemical homeostasis within a tissue (GO:0048875) | 3.67184521 |
| 39 | atrioventricular valve morphogenesis (GO:0003181) | 3.66496503 |
| 40 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.66396672 |
| 41 | regulation of hypersensitivity (GO:0002883) | 3.53652795 |
| 42 | regulation of cell proliferation involved in kidney development (GO:1901722) | 3.42881269 |
| 43 | negative regulation of cell fate specification (GO:0009996) | 3.39815256 |
| 44 | primary alcohol catabolic process (GO:0034310) | 3.37936812 |
| 45 | eyelid development in camera-type eye (GO:0061029) | 3.33561693 |
| 46 | gland morphogenesis (GO:0022612) | 3.28814201 |
| 47 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 3.26982849 |
| 48 | adhesion of symbiont to host cell (GO:0044650) | 3.25279820 |
| 49 | virion attachment to host cell (GO:0019062) | 3.25279820 |
| 50 | ceramide biosynthetic process (GO:0046513) | 3.23303033 |
| 51 | positive regulation of epidermis development (GO:0045684) | 3.21782350 |
| 52 | viral transcription (GO:0019083) | 3.21723939 |
| 53 | regulation of epidermal cell differentiation (GO:0045604) | 3.19199057 |
| 54 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 3.19106768 |
| 55 | cardiac right ventricle morphogenesis (GO:0003215) | 3.16924124 |
| 56 | negative regulation of kidney development (GO:0090185) | 3.16358578 |
| 57 | prostanoid biosynthetic process (GO:0046457) | 3.15101702 |
| 58 | prostaglandin biosynthetic process (GO:0001516) | 3.15101702 |
| 59 | phosphatidylserine metabolic process (GO:0006658) | 3.14937673 |
| 60 | lipoxygenase pathway (GO:0019372) | 3.14820355 |
| 61 | long-chain fatty-acyl-CoA metabolic process (GO:0035336) | 3.14325368 |
| 62 | detection of other organism (GO:0098543) | 3.10244238 |
| 63 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.09954776 |
| 64 | lateral sprouting from an epithelium (GO:0060601) | 3.09725264 |
| 65 | positive regulation of chemokine secretion (GO:0090197) | 3.07868112 |
| 66 | sequestering of metal ion (GO:0051238) | 3.06862292 |
| 67 | epithelium development (GO:0060429) | 3.06494152 |
| 68 | phosphatidylethanolamine acyl-chain remodeling (GO:0036152) | 3.04789894 |
| 69 | cyclooxygenase pathway (GO:0019371) | 3.02728797 |
| 70 | translational termination (GO:0006415) | 3.00624125 |
| 71 | skin development (GO:0043588) | 2.96755892 |
| 72 | negative regulation of interferon-gamma production (GO:0032689) | 2.95365048 |
| 73 | regulation of cardioblast differentiation (GO:0051890) | 2.92497578 |
| 74 | establishment of planar polarity (GO:0001736) | 2.90463996 |
| 75 | establishment of tissue polarity (GO:0007164) | 2.90463996 |
| 76 | negative regulation of interleukin-2 production (GO:0032703) | 2.89397698 |
| 77 | negative regulation of cell fate commitment (GO:0010454) | 2.84620103 |
| 78 | hair follicle morphogenesis (GO:0031069) | 2.83076454 |
| 79 | regulation of interleukin-8 secretion (GO:2000482) | 2.83032755 |
| 80 | epithelial cell-cell adhesion (GO:0090136) | 2.81123941 |
| 81 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.80929291 |
| 82 | regulation of epidermis development (GO:0045682) | 2.79486205 |
| 83 | cell-substrate junction assembly (GO:0007044) | 2.79356702 |
| 84 | positive regulation of hair cycle (GO:0042635) | 2.78586166 |
| 85 | positive regulation of hair follicle development (GO:0051798) | 2.78586166 |
| 86 | regulation of T cell chemotaxis (GO:0010819) | 2.78396426 |
| 87 | positive regulation of T cell chemotaxis (GO:0010820) | 2.78396426 |
| 88 | ribosomal small subunit biogenesis (GO:0042274) | 2.77744194 |
| 89 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 2.75671789 |
| 90 | cardiolipin metabolic process (GO:0032048) | 2.74906002 |
| 91 | positive regulation of epidermal cell differentiation (GO:0045606) | 2.74786919 |
| 92 | regulation of heart rate by cardiac conduction (GO:0086091) | 2.74730806 |
| 93 | phosphatidylcholine acyl-chain remodeling (GO:0036151) | 2.74310889 |
| 94 | regulation of glomerular filtration (GO:0003093) | 2.74264302 |
| 95 | positive regulation of interleukin-4 production (GO:0032753) | 2.70911390 |
| 96 | negative regulation of actin filament bundle assembly (GO:0032232) | 2.69252955 |
| 97 | epithelial cell differentiation (GO:0030855) | 2.68823261 |
| 98 | regulation of keratinocyte proliferation (GO:0010837) | 2.65847921 |
| 99 | ventricular cardiac muscle cell action potential (GO:0086005) | 2.65749778 |
| 100 | cell communication involved in cardiac conduction (GO:0086065) | 2.65026503 |
| 101 | limb bud formation (GO:0060174) | 2.64188443 |
| 102 | phosphatidylglycerol acyl-chain remodeling (GO:0036148) | 2.62804062 |
| 103 | detection of external biotic stimulus (GO:0098581) | 2.62504677 |
| 104 | negative regulation of T cell mediated immunity (GO:0002710) | 2.62201600 |
| 105 | amino sugar catabolic process (GO:0046348) | 2.60363443 |
| 106 | alditol phosphate metabolic process (GO:0052646) | 2.60312058 |
| 107 | regulation of keratinocyte differentiation (GO:0045616) | 2.59041863 |
| 108 | positive regulation of epidermal growth factor-activated receptor activity (GO:0045741) | 2.58212344 |
| 109 | intestinal epithelial cell development (GO:0060576) | 2.55716186 |
| 110 | regulation of monocyte chemotaxis (GO:0090025) | 2.54082267 |
| 111 | hair cycle process (GO:0022405) | 2.53377502 |
| 112 | molting cycle process (GO:0022404) | 2.53377502 |
| 113 | fatty-acyl-CoA metabolic process (GO:0035337) | 2.52953859 |
| 114 | regulation of hair follicle development (GO:0051797) | 2.51636878 |
| 115 | prostanoid metabolic process (GO:0006692) | 2.50993271 |
| 116 | prostaglandin metabolic process (GO:0006693) | 2.50993271 |
| 117 | morphogenesis of embryonic epithelium (GO:0016331) | 2.33738628 |
| 118 | phospholipid catabolic process (GO:0009395) | 2.32822593 |
| 119 | sphingolipid biosynthetic process (GO:0030148) | 2.30506206 |
| 120 | cell-cell junction assembly (GO:0007043) | 2.29516721 |
| 121 | negative regulation of interleukin-17 production (GO:0032700) | 2.26260967 |
| 122 | cellular component disassembly involved in execution phase of apoptosis (GO:0006921) | 2.26064522 |
| 123 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.25475192 |
| 124 | response to phenylpropanoid (GO:0080184) | 2.24984756 |
| 125 | regulation of protein localization to cell surface (GO:2000008) | 2.24495504 |
| 126 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.23462866 |
| 127 | regulation of hair cycle (GO:0042634) | 2.22268691 |
| 128 | negative regulation of epidermis development (GO:0045683) | 2.21782476 |
| 129 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.20808484 |
| 130 | detection of biotic stimulus (GO:0009595) | 2.17791554 |
| 131 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.16105459 |
| 132 | regulation of Cdc42 GTPase activity (GO:0043088) | 2.15746349 |
| 133 | positive regulation of cholesterol efflux (GO:0010875) | 2.15656958 |
| 134 | desmosome organization (GO:0002934) | 17.2036458 |
| 135 | keratinization (GO:0031424) | 13.7268024 |
| 136 | establishment of skin barrier (GO:0061436) | 12.7456583 |
| 137 | regulation of water loss via skin (GO:0033561) | 11.7838295 |
| 138 | molting cycle (GO:0042303) | 10.6370656 |
| 139 | hair cycle (GO:0042633) | 10.6370656 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 5.97634586 |
| 2 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 3.05144240 |
| 3 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 2.66951511 |
| 4 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.55566319 |
| 5 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.34472933 |
| 6 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.31907698 |
| 7 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.14659386 |
| 8 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.14286170 |
| 9 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 16.5505433 |
| 10 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.96737238 |
| 11 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.94406374 |
| 12 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.93661415 |
| 13 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.93661415 |
| 14 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.87711195 |
| 15 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.71212481 |
| 16 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.69241498 |
| 17 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.55674404 |
| 18 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.53186374 |
| 19 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.48378794 |
| 20 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.48075864 |
| 21 | TP63_23658742_ChIP-Seq_EP156T_Human | 1.44628875 |
| 22 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.42966592 |
| 23 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.34800771 |
| 24 | CJUN_26792858_Chip-Seq_BT549_Human | 1.32328624 |
| 25 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.29371310 |
| 26 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.28537286 |
| 27 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.26002240 |
| 28 | * TP63_22573176_ChIP-Seq_HFKS_Human | 1.25737893 |
| 29 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.25726864 |
| 30 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.23941270 |
| 31 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.19215226 |
| 32 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 1.19079247 |
| 33 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.18872001 |
| 34 | RXR_22108803_ChIP-Seq_LS180_Human | 1.17945758 |
| 35 | * KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.17510195 |
| 36 | * CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.17031811 |
| 37 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.16976072 |
| 38 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.15875469 |
| 39 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.15294999 |
| 40 | P68_20966046_ChIP-Seq_HELA_Human | 1.11718151 |
| 41 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.11168443 |
| 42 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.10525919 |
| 43 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.10197416 |
| 44 | ATF3_27146783_Chip-Seq_COLON_Human | 1.09044774 |
| 45 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.08091211 |
| 46 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.07573399 |
| 47 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.06144737 |
| 48 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.05604282 |
| 49 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.04323882 |
| 50 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.03614933 |
| 51 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.03593879 |
| 52 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.02498748 |
| 53 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.01456254 |
| 54 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.99550919 |
| 55 | * DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.98794686 |
| 56 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.98683343 |
| 57 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.97914228 |
| 58 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.97706026 |
| 59 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.97309606 |
| 60 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.96254382 |
| 61 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.93486015 |
| 62 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.93307367 |
| 63 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.93070529 |
| 64 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.92871119 |
| 65 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.92851782 |
| 66 | * KDM2B_26808549_Chip-Seq_DND41_Human | 0.92756538 |
| 67 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.92662019 |
| 68 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.92057929 |
| 69 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.91860185 |
| 70 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.90317695 |
| 71 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.87276090 |
| 72 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.86954425 |
| 73 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.84477038 |
| 74 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.84283612 |
| 75 | * CEBPB_22108803_ChIP-Seq_LS180_Human | 0.84154203 |
| 76 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.83159477 |
| 77 | * P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.80699004 |
| 78 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.80570140 |
| 79 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.79871632 |
| 80 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.79560490 |
| 81 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.79553122 |
| 82 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.79330645 |
| 83 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.79324311 |
| 84 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.79166799 |
| 85 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.79030829 |
| 86 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.78607634 |
| 87 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.78451448 |
| 88 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.77376778 |
| 89 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.76297792 |
| 90 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.76114004 |
| 91 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.75873389 |
| 92 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.74496158 |
| 93 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.74228033 |
| 94 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.74147402 |
| 95 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.73865526 |
| 96 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.73773355 |
| 97 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.73709002 |
| 98 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.73680138 |
| 99 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.73643871 |
| 100 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.72208742 |
| 101 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.72203661 |
| 102 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.72146600 |
| 103 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.71911244 |
| 104 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.71626039 |
| 105 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.71391884 |
| 106 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.71304848 |
| 107 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.71129879 |
| 108 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 0.70545177 |
| 109 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.70027115 |
| 110 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.69899652 |
| 111 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.69345429 |
| 112 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.69255490 |
| 113 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.69017413 |
| 114 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.68786328 |
| 115 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.68654750 |
| 116 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.68546957 |
| 117 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.68332653 |
| 118 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.68030866 |
| 119 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.67462747 |
| 120 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.65517217 |
| 121 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.64196785 |
| 122 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 0.63349008 |
| 123 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.63044249 |
| 124 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.62701694 |
| 125 | KDM2B_26808549_Chip-Seq_K562_Human | 0.61105931 |
| 126 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.60754797 |
| 127 | SA1_27219007_Chip-Seq_Bcells_Human | 0.59019586 |
| 128 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.58796614 |
| 129 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.58542845 |
| 130 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.58040232 |
| 131 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 0.57992427 |
| 132 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.57773556 |
| 133 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.56866553 |
| 134 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.56866553 |
| 135 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.56666576 |
| 136 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.56233651 |
| 137 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.55964820 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002796_impaired_skin_barrier | 7.95334134 |
| 2 | MP0005275_abnormal_skin_tensile | 5.63729389 |
| 3 | MP0005501_abnormal_skin_physiology | 4.99672307 |
| 4 | MP0010234_abnormal_vibrissa_follicle | 4.85586902 |
| 5 | MP0003941_abnormal_skin_development | 4.84834069 |
| 6 | MP0000579_abnormal_nail_morphology | 4.61461315 |
| 7 | MP0004381_abnormal_hair_follicle | 3.89376742 |
| 8 | MP0001216_abnormal_epidermal_layer | 3.68334313 |
| 9 | MP0000383_abnormal_hair_follicle | 3.56256819 |
| 10 | MP0002060_abnormal_skin_morphology | 3.48634010 |
| 11 | MP0002098_abnormal_vibrissa_morphology | 3.31481894 |
| 12 | MP0010678_abnormal_skin_adnexa | 3.18953504 |
| 13 | MP0010771_integument_phenotype | 3.16343634 |
| 14 | MP0003453_abnormal_keratinocyte_physiol | 3.16112648 |
| 15 | MP0002254_reproductive_system_inflammat | 3.03080089 |
| 16 | MP0000647_abnormal_sebaceous_gland | 3.02151733 |
| 17 | MP0000566_synostosis | 2.90306327 |
| 18 | MP0000467_abnormal_esophagus_morphology | 2.83343390 |
| 19 | MP0000377_abnormal_hair_follicle | 2.63345656 |
| 20 | MP0004947_skin_inflammation | 2.42090689 |
| 21 | MP0000427_abnormal_hair_cycle | 2.38602860 |
| 22 | MP0003878_abnormal_ear_physiology | 2.31324465 |
| 23 | MP0005377_hearing/vestibular/ear_phenot | 2.31324465 |
| 24 | MP0003705_abnormal_hypodermis_morpholog | 2.30578127 |
| 25 | MP0000762_abnormal_tongue_morphology | 2.17583795 |
| 26 | MP0005451_abnormal_body_composition | 2.15664149 |
| 27 | MP0003566_abnormal_cell_adhesion | 1.98223783 |
| 28 | MP0004885_abnormal_endolymph | 1.89286494 |
| 29 | MP0009931_abnormal_skin_appearance | 1.76504957 |
| 30 | MP0004185_abnormal_adipocyte_glucose | 1.73893630 |
| 31 | MP0001346_abnormal_lacrimal_gland | 1.64906588 |
| 32 | MP0001191_abnormal_skin_condition | 1.64010264 |
| 33 | MP0000367_abnormal_coat/_hair | 1.52192593 |
| 34 | MP0001243_abnormal_dermal_layer | 1.50338755 |
| 35 | MP0002009_preneoplasia | 1.42556340 |
| 36 | MP0002234_abnormal_pharynx_morphology | 1.38157534 |
| 37 | MP0001851_eye_inflammation | 1.21646029 |
| 38 | MP0009053_abnormal_anal_canal | 1.14142656 |
| 39 | MP0009379_abnormal_foot_pigmentation | 1.12231385 |
| 40 | MP0001340_abnormal_eyelid_morphology | 1.06854778 |
| 41 | MP0005023_abnormal_wound_healing | 0.93846206 |
| 42 | MP0010352_gastrointestinal_tract_polyps | 0.90047032 |
| 43 | MP0008004_abnormal_stomach_pH | 0.88033740 |
| 44 | MP0003011_delayed_dark_adaptation | 0.84114855 |
| 45 | MP0000465_gastrointestinal_hemorrhage | 0.83873293 |
| 46 | MP0005409_darkened_coat_color | 0.82937259 |
| 47 | MP0008260_abnormal_autophagy | 0.78917047 |
| 48 | MP0000627_abnormal_mammary_gland | 0.77060521 |
| 49 | MP0003315_abnormal_perineum_morphology | 0.74689084 |
| 50 | MP0002282_abnormal_trachea_morphology | 0.74390849 |
| 51 | MP0002177_abnormal_outer_ear | 0.70492792 |
| 52 | MP0010030_abnormal_orbit_morphology | 0.69884545 |
| 53 | MP0009780_abnormal_chondrocyte_physiolo | 0.67981553 |
| 54 | MP0003950_abnormal_plasma_membrane | 0.66989625 |
| 55 | MP0003755_abnormal_palate_morphology | 0.66983592 |
| 56 | MP0001849_ear_inflammation | 0.66774225 |
| 57 | MP0004043_abnormal_pH_regulation | 0.64651573 |
| 58 | MP0005076_abnormal_cell_differentiation | 0.63275923 |
| 59 | MP0004782_abnormal_surfactant_physiolog | 0.63080277 |
| 60 | MP0002095_abnormal_skin_pigmentation | 0.61451095 |
| 61 | MP0001784_abnormal_fluid_regulation | 0.58926452 |
| 62 | MP0002006_tumorigenesis | 0.58591457 |
| 63 | MP0002249_abnormal_larynx_morphology | 0.58316660 |
| 64 | MP0002877_abnormal_melanocyte_morpholog | 0.58248919 |
| 65 | MP0003191_abnormal_cellular_cholesterol | 0.57417932 |
| 66 | MP0004264_abnormal_extraembryonic_tissu | 0.55997444 |
| 67 | MP0000538_abnormal_urinary_bladder | 0.53938368 |
| 68 | MP0002111_abnormal_tail_morphology | 0.51572439 |
| 69 | MP0003436_decreased_susceptibility_to | 0.49951009 |
| 70 | MP0004272_abnormal_basement_membrane | 0.47879309 |
| 71 | MP0005075_abnormal_melanosome_morpholog | 0.47351963 |
| 72 | MP0003763_abnormal_thymus_physiology | 0.46302094 |
| 73 | MP0005508_abnormal_skeleton_morphology | 0.45359910 |
| 74 | MP0000678_abnormal_parathyroid_gland | 0.44835361 |
| 75 | MP0003136_yellow_coat_color | 0.44555448 |
| 76 | MP0001984_abnormal_olfaction | 0.44112019 |
| 77 | MP0005666_abnormal_adipose_tissue | 0.43690596 |
| 78 | MP0009384_cardiac_valve_regurgitation | 0.43678427 |
| 79 | MP0000015_abnormal_ear_pigmentation | 0.41621319 |
| 80 | MP0000516_abnormal_urinary_system | 0.41214130 |
| 81 | MP0005367_renal/urinary_system_phenotyp | 0.41214130 |
| 82 | MP0009250_abnormal_appendicular_skeleto | 0.40741133 |
| 83 | MP0000537_abnormal_urethra_morphology | 0.40471589 |
| 84 | MP0004019_abnormal_vitamin_homeostasis | 0.39444793 |
| 85 | MP0005248_abnormal_Harderian_gland | 0.39326982 |
| 86 | MP0002166_altered_tumor_susceptibility | 0.37768544 |
| 87 | MP0003385_abnormal_body_wall | 0.36882570 |
| 88 | MP0001188_hyperpigmentation | 0.35792475 |
| 89 | MP0000858_altered_metastatic_potential | 0.35355461 |
| 90 | MP0002233_abnormal_nose_morphology | 0.35132434 |
| 91 | MP0000470_abnormal_stomach_morphology | 0.34462941 |
| 92 | MP0001186_pigmentation_phenotype | 0.34052049 |
| 93 | MP0009672_abnormal_birth_weight | 0.33284764 |
| 94 | MP0000003_abnormal_adipose_tissue | 0.33097270 |
| 95 | MP0000613_abnormal_salivary_gland | 0.32615834 |
| 96 | MP0009333_abnormal_splenocyte_physiolog | 0.31201667 |
| 97 | MP0003718_maternal_effect | 0.30254764 |
| 98 | MP0000432_abnormal_head_morphology | 0.30171247 |
| 99 | MP0005375_adipose_tissue_phenotype | 0.28214438 |
| 100 | MP0002148_abnormal_hypersensitivity_rea | 0.27608457 |
| 101 | MP0002109_abnormal_limb_morphology | 0.27435768 |
| 102 | MP0002277_abnormal_respiratory_mucosa | 0.27347876 |
| 103 | MP0005390_skeleton_phenotype | 0.25962326 |
| 104 | MP0000462_abnormal_digestive_system | 0.25916613 |
| 105 | MP0005394_taste/olfaction_phenotype | 0.24638386 |
| 106 | MP0005499_abnormal_olfactory_system | 0.24638386 |
| 107 | MP0000750_abnormal_muscle_regeneration | 0.24548632 |
| 108 | MP0005174_abnormal_tail_pigmentation | 0.24493126 |
| 109 | MP0005257_abnormal_intraocular_pressure | 0.24445279 |
| 110 | MP0003638_abnormal_response/metabolism_ | 0.23544804 |
| 111 | MP0004858_abnormal_nervous_system | 0.20283798 |
| 112 | MP0003938_abnormal_ear_development | 0.19568743 |
| 113 | MP0002075_abnormal_coat/hair_pigmentati | 0.19092265 |
| 114 | MP0003936_abnormal_reproductive_system | 0.19053498 |
| 115 | MP0008789_abnormal_olfactory_epithelium | 0.19000143 |
| 116 | MP0002697_abnormal_eye_size | 0.18588457 |
| 117 | MP0002896_abnormal_bone_mineralization | 0.17067445 |
| 118 | MP0006054_spinal_hemorrhage | 0.16365086 |
| 119 | MP0006138_congestive_heart_failure | 0.15983365 |
| 120 | MP0001765_abnormal_ion_homeostasis | 0.15620542 |
| 121 | MP0001533_abnormal_skeleton_physiology | 0.14564151 |
| 122 | MP0004197_abnormal_fetal_growth/weight/ | 0.14360026 |
| 123 | MP0005193_abnormal_anterior_eye | 0.14157008 |
| 124 | MP0001881_abnormal_mammary_gland | 0.13166177 |
| 125 | MP0002089_abnormal_postnatal_growth/wei | 0.12810588 |
| 126 | MP0000371_diluted_coat_color | 0.12153381 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hypotrichosis (HP:0001006) | 8.15629728 |
| 2 | Abnormality of nail color (HP:0100643) | 7.19411214 |
| 3 | Plantar hyperkeratosis (HP:0007556) | 7.06115675 |
| 4 | Palmoplantar hyperkeratosis (HP:0000972) | 6.84519688 |
| 5 | Woolly hair (HP:0002224) | 6.54468437 |
| 6 | Increased IgE level (HP:0003212) | 6.48049197 |
| 7 | Palmar hyperkeratosis (HP:0010765) | 6.43794387 |
| 8 | Right ventricular cardiomyopathy (HP:0011663) | 6.16009608 |
| 9 | Erythema (HP:0010783) | 5.75214232 |
| 10 | Congenital ichthyosiform erythroderma (HP:0007431) | 5.68477931 |
| 11 | Lip pit (HP:0100267) | 5.68334526 |
| 12 | Onycholysis (HP:0001806) | 5.67144942 |
| 13 | Parakeratosis (HP:0001036) | 5.63657813 |
| 14 | Fragile nails (HP:0001808) | 5.61078447 |
| 15 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 5.59464011 |
| 16 | Erythroderma (HP:0001019) | 5.41682142 |
| 17 | Thick nail (HP:0001805) | 5.19452057 |
| 18 | Conjunctival hamartoma (HP:0100780) | 5.16519747 |
| 19 | Milia (HP:0001056) | 5.10860172 |
| 20 | Pili torti (HP:0003777) | 4.65848312 |
| 21 | Abnormal blistering of the skin (HP:0008066) | 4.52210932 |
| 22 | Nail dystrophy (HP:0008404) | 4.19419819 |
| 23 | Absent eyelashes (HP:0000561) | 3.79294004 |
| 24 | Natal tooth (HP:0000695) | 3.76755052 |
| 25 | Ectropion (HP:0000656) | 3.71753301 |
| 26 | Popliteal pterygium (HP:0009756) | 3.63867858 |
| 27 | Advanced eruption of teeth (HP:0006288) | 3.49477172 |
| 28 | Sparse eyelashes (HP:0000653) | 3.44787616 |
| 29 | Corneal erosion (HP:0200020) | 3.44280889 |
| 30 | Alopecia of scalp (HP:0002293) | 3.40800766 |
| 31 | Hypohidrosis (HP:0000966) | 3.36467415 |
| 32 | Palmoplantar keratoderma (HP:0000982) | 3.31362469 |
| 33 | Abnormality of the axillary hair (HP:0100134) | 3.29578668 |
| 34 | Abnormality of secondary sexual hair (HP:0009888) | 3.29578668 |
| 35 | Gangrene (HP:0100758) | 3.17653337 |
| 36 | Ventricular tachycardia (HP:0004756) | 3.15558665 |
| 37 | Sparse scalp hair (HP:0002209) | 3.14619890 |
| 38 | Absent hair (HP:0002298) | 3.02095156 |
| 39 | Atrophic scars (HP:0001075) | 3.00634799 |
| 40 | Abnormal hair laboratory examination (HP:0003328) | 2.99283906 |
| 41 | Hamartoma of the eye (HP:0010568) | 2.98271532 |
| 42 | Pruritus (HP:0000989) | 2.87414372 |
| 43 | Distal lower limb muscle weakness (HP:0009053) | 2.83240814 |
| 44 | Acanthosis nigricans (HP:0000956) | 2.82021716 |
| 45 | Curly hair (HP:0002212) | 2.79609566 |
| 46 | Ridged nail (HP:0001807) | 2.74776006 |
| 47 | Hyporeflexia of lower limbs (HP:0002600) | 2.69974459 |
| 48 | Hypoplastic labia majora (HP:0000059) | 2.68699665 |
| 49 | Abnormality of placental membranes (HP:0011409) | 2.66369546 |
| 50 | Amniotic constriction ring (HP:0009775) | 2.66369546 |
| 51 | Abnormality of the salivary glands (HP:0010286) | 2.63428238 |
| 52 | Follicular hyperkeratosis (HP:0007502) | 2.55567153 |
| 53 | Brittle hair (HP:0002299) | 2.52104155 |
| 54 | Pterygium (HP:0001059) | 2.51551813 |
| 55 | Oral leukoplakia (HP:0002745) | 2.47877338 |
| 56 | Septate vagina (HP:0001153) | 2.45130279 |
| 57 | Abnormality of the labia majora (HP:0012881) | 2.44871165 |
| 58 | Aplasia cutis congenita (HP:0001057) | 2.40192784 |
| 59 | Abnormality of the neuromuscular junction (HP:0003398) | 2.29616751 |
| 60 | Fatigable weakness (HP:0003473) | 2.29616751 |
| 61 | Pustule (HP:0200039) | 2.28699149 |
| 62 | Abnormality of hair growth rate (HP:0011363) | 2.27536231 |
| 63 | Selective tooth agenesis (HP:0001592) | 2.27533584 |
| 64 | Furrowed tongue (HP:0000221) | 2.23778437 |
| 65 | Autoamputation (HP:0001218) | 2.22842384 |
| 66 | Severe Myopia (HP:0011003) | 2.19912712 |
| 67 | Blepharitis (HP:0000498) | 2.14704281 |
| 68 | Corneal dystrophy (HP:0001131) | 2.11612706 |
| 69 | Ventricular fibrillation (HP:0001663) | 2.11476910 |
| 70 | Concave nail (HP:0001598) | 2.11151049 |
| 71 | Anonychia (HP:0001798) | 2.06598791 |
| 72 | Abnormality of the gastric mucosa (HP:0004295) | 2.04407525 |
| 73 | Down-sloping shoulders (HP:0200021) | 2.00552111 |
| 74 | Oligodontia (HP:0000677) | 2.00432899 |
| 75 | Fragile skin (HP:0001030) | 1.98414667 |
| 76 | Multifactorial inheritance (HP:0001426) | 1.97967491 |
| 77 | Hypoplasia of dental enamel (HP:0006297) | 1.97265225 |
| 78 | Increased connective tissue (HP:0009025) | 1.95428280 |
| 79 | Congenital, generalized hypertrichosis (HP:0004540) | 1.91921323 |
| 80 | Melanocytic nevus (HP:0000995) | 1.89543204 |
| 81 | Laryngomalacia (HP:0001601) | 1.89088781 |
| 82 | Dry skin (HP:0000958) | 1.87977729 |
| 83 | Hypergammaglobulinemia (HP:0010702) | 1.87000372 |
| 84 | Carious teeth (HP:0000670) | 1.86893347 |
| 85 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.81391569 |
| 86 | Aplasia of the phalanges of the hand (HP:0009802) | 1.81391569 |
| 87 | Aplasia involving bones of the extremities (HP:0009825) | 1.81391569 |
| 88 | Skin pits (HP:0100276) | 1.80376708 |
| 89 | Abnormality of permanent molar morphology (HP:0011071) | 1.79236506 |
| 90 | Abnormality of the dental root (HP:0006486) | 1.79236506 |
| 91 | Taurodontia (HP:0000679) | 1.79236506 |
| 92 | Hyperhidrosis (HP:0000975) | 1.76568721 |
| 93 | Hypodontia (HP:0000668) | 1.75359715 |
| 94 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.74690517 |
| 95 | Lack of skin elasticity (HP:0100679) | 1.74182243 |
| 96 | Fine hair (HP:0002213) | 1.73411559 |
| 97 | Dehydration (HP:0001944) | 1.72460942 |
| 98 | Nasolacrimal duct obstruction (HP:0000579) | 1.71056068 |
| 99 | Urticaria (HP:0001025) | 1.70571145 |
| 100 | Areflexia of lower limbs (HP:0002522) | 1.70501359 |
| 101 | Recurrent corneal erosions (HP:0000495) | 1.69592718 |
| 102 | Skin ulcer (HP:0200042) | 1.69521178 |
| 103 | Dry hair (HP:0011359) | 1.66302656 |
| 104 | Myopathic facies (HP:0002058) | 1.65967918 |
| 105 | Abnormality of molar (HP:0011077) | 1.65678193 |
| 106 | Abnormality of molar morphology (HP:0011070) | 1.65678193 |
| 107 | Type 1 muscle fiber predominance (HP:0003803) | 1.60365906 |
| 108 | Hamartoma (HP:0010566) | 1.58318395 |
| 109 | Achilles tendon contracture (HP:0001771) | 1.57296419 |
| 110 | Labial hypoplasia (HP:0000066) | 1.56995982 |
| 111 | Abnormality of the dental pulp (HP:0006479) | 1.56023566 |
| 112 | Round ear (HP:0100830) | 1.54904312 |
| 113 | Paralysis (HP:0003470) | 1.53167749 |
| 114 | Axonal loss (HP:0003447) | 1.53131908 |
| 115 | Neonatal death (HP:0003811) | 1.53011537 |
| 116 | Malignant hyperthermia (HP:0002047) | 1.51317530 |
| 117 | Hypoplastic toenails (HP:0001800) | 1.51263409 |
| 118 | Amelogenesis imperfecta (HP:0000705) | 1.50445296 |
| 119 | Trismus (HP:0000211) | 1.49786229 |
| 120 | Ulnar claw (HP:0001178) | 1.49724481 |
| 121 | Hypoparathyroidism (HP:0000829) | 1.48883349 |
| 122 | Eczematoid dermatitis (HP:0000976) | 1.46006046 |
| 123 | Duplicated collecting system (HP:0000081) | 1.45201570 |
| 124 | Abnormality of the fingernails (HP:0001231) | 1.43977796 |
| 125 | Seborrheic dermatitis (HP:0001051) | 1.43866897 |
| 126 | Hypoplastic female external genitalia (HP:0012815) | 1.43568607 |
| 127 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.42778635 |
| 128 | Sudden death (HP:0001699) | 1.42441702 |
| 129 | Anhidrosis (HP:0000970) | 1.42158679 |
| 130 | Slow-growing hair (HP:0002217) | 1.42036236 |
| 131 | Breast hypoplasia (HP:0003187) | 1.40897304 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST1R | 5.12631247 |
| 2 | MAPKAPK3 | 5.01046552 |
| 3 | MAP3K3 | 4.98846122 |
| 4 | MST4 | 4.07579880 |
| 5 | FER | 3.66996646 |
| 6 | MAP3K2 | 2.96545433 |
| 7 | TGFBR1 | 2.51752031 |
| 8 | RPS6KB2 | 2.49333372 |
| 9 | PIK3CG | 2.48061770 |
| 10 | LATS1 | 2.39223147 |
| 11 | TRPM7 | 2.21280523 |
| 12 | EPHA2 | 2.12043186 |
| 13 | CDK12 | 2.06569387 |
| 14 | PIM2 | 2.04816519 |
| 15 | EPHB2 | 2.03645087 |
| 16 | MAPKAPK5 | 1.90552777 |
| 17 | PKN2 | 1.86986491 |
| 18 | TAOK1 | 1.79823256 |
| 19 | ERN1 | 1.74856089 |
| 20 | STK24 | 1.66549467 |
| 21 | EEF2K | 1.66380604 |
| 22 | GRK6 | 1.65230583 |
| 23 | SMG1 | 1.64477772 |
| 24 | MET | 1.62942704 |
| 25 | EPHA3 | 1.56483111 |
| 26 | MAP3K9 | 1.52342667 |
| 27 | BLK | 1.49424962 |
| 28 | NTRK2 | 1.44179517 |
| 29 | MAP3K6 | 1.42354784 |
| 30 | RPS6KA4 | 1.41154606 |
| 31 | NME2 | 1.40306468 |
| 32 | FGFR4 | 1.35033249 |
| 33 | LRRK2 | 1.30944776 |
| 34 | FGFR2 | 1.30910719 |
| 35 | STK10 | 1.25741324 |
| 36 | ERBB3 | 1.21448737 |
| 37 | PBK | 1.18365028 |
| 38 | SIK3 | 1.13394990 |
| 39 | MAP2K6 | 1.05538545 |
| 40 | TTN | 1.04521970 |
| 41 | BCR | 1.02830818 |
| 42 | PRPF4B | 1.02572668 |
| 43 | FGFR3 | 1.02093317 |
| 44 | NEK6 | 1.01936014 |
| 45 | DYRK1B | 1.01243174 |
| 46 | MAP3K11 | 1.00838998 |
| 47 | PTK6 | 0.97988788 |
| 48 | MAP3K1 | 0.97696761 |
| 49 | EPHB1 | 0.95965759 |
| 50 | LATS2 | 0.95278110 |
| 51 | CDK3 | 0.94165290 |
| 52 | MUSK | 0.91787480 |
| 53 | DMPK | 0.89352573 |
| 54 | MTOR | 0.88096088 |
| 55 | MAP2K2 | 0.88017579 |
| 56 | MAPKAPK2 | 0.87131291 |
| 57 | CDK6 | 0.83264146 |
| 58 | ICK | 0.79777794 |
| 59 | NME1 | 0.79709695 |
| 60 | STK38L | 0.78069969 |
| 61 | MAP3K7 | 0.77724334 |
| 62 | TRIB3 | 0.76221592 |
| 63 | TTK | 0.75932382 |
| 64 | TGFBR2 | 0.75678650 |
| 65 | MAP3K12 | 0.74171967 |
| 66 | BRAF | 0.74159678 |
| 67 | TYK2 | 0.73658730 |
| 68 | TESK1 | 0.72036567 |
| 69 | OBSCN | 0.71309353 |
| 70 | FGFR1 | 0.68707475 |
| 71 | STK38 | 0.66684029 |
| 72 | PRKCI | 0.65945880 |
| 73 | PAK4 | 0.65876026 |
| 74 | SGK494 | 0.65231196 |
| 75 | SGK223 | 0.65231196 |
| 76 | PDGFRA | 0.64749396 |
| 77 | PTK2 | 0.62572991 |
| 78 | ILK | 0.62224891 |
| 79 | GRK1 | 0.57443489 |
| 80 | PRKD1 | 0.54379427 |
| 81 | RET | 0.54047045 |
| 82 | MAPK7 | 0.54043799 |
| 83 | CDK19 | 0.53470210 |
| 84 | ARAF | 0.53235920 |
| 85 | RPS6KB1 | 0.52696502 |
| 86 | RIPK1 | 0.52449349 |
| 87 | PDK2 | 0.51867663 |
| 88 | ERBB4 | 0.51840494 |
| 89 | CHUK | 0.51556517 |
| 90 | IRAK1 | 0.50733476 |
| 91 | CDK7 | 0.49954631 |
| 92 | MAP3K5 | 0.49948174 |
| 93 | RPS6KA2 | 0.48909173 |
| 94 | STK3 | 0.47633196 |
| 95 | MAP2K3 | 0.47631471 |
| 96 | SCYL2 | 0.45792789 |
| 97 | MAP3K14 | 0.44020736 |
| 98 | RIPK4 | 0.43717544 |
| 99 | RPS6KA1 | 0.43231130 |
| 100 | STK11 | 0.41756942 |
| 101 | CSNK1D | 0.41736232 |
| 102 | TYRO3 | 0.40922851 |
| 103 | BMX | 0.38920236 |
| 104 | ERBB2 | 0.38704027 |
| 105 | NTRK1 | 0.38512252 |
| 106 | MAPK12 | 0.38365889 |
| 107 | TESK2 | 0.37672090 |
| 108 | PRKD2 | 0.34944773 |
| 109 | IRAK2 | 0.34728900 |
| 110 | MAP2K1 | 0.34261735 |
| 111 | IRAK3 | 0.33636802 |
| 112 | EPHA4 | 0.32916440 |
| 113 | ADRBK1 | 0.32769591 |
| 114 | PIK3CA | 0.32545697 |
| 115 | SIK1 | 0.32420629 |
| 116 | PKN1 | 0.31641772 |
| 117 | ROCK1 | 0.31304672 |
| 118 | CDC42BPA | 0.31258689 |
| 119 | DDR2 | 0.30102943 |
| 120 | IKBKE | 0.29949179 |
| 121 | PDPK1 | 0.29897896 |
| 122 | MAPK4 | 0.29724328 |
| 123 | LIMK1 | 0.29566457 |
| 124 | KSR2 | 0.29485554 |
| 125 | TBK1 | 0.28432779 |
| 126 | GRK7 | 0.28340603 |
| 127 | MAPK15 | 0.27923283 |
| 128 | NLK | 0.27865872 |
| 129 | MARK2 | 0.27182360 |
| 130 | HCK | 0.26899901 |
| 131 | JAK2 | 0.26476934 |
| 132 | MOS | 0.26442291 |
| 133 | PAK3 | 0.26334890 |
| 134 | ITK | 0.25914328 |
| 135 | HIPK2 | 0.25835140 |
| 136 | IKBKB | 0.25685825 |
| 137 | MAP2K4 | 0.24981240 |
| 138 | GSK3A | 0.24451240 |
| 139 | PRKCE | 0.23751517 |
| 140 | MATK | 0.22486858 |
| 141 | PDGFRB | 0.21598128 |
| 142 | JAK3 | 0.17802348 |
| 143 | ABL2 | 0.16288068 |
| 144 | MAPK8 | 0.15741797 |
| 145 | MAPK9 | 0.15657767 |
| 146 | RPS6KL1 | 0.14622799 |
| 147 | RPS6KC1 | 0.14622799 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 3.67703887 |
| 2 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.48685698 |
| 3 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 3.35031841 |
| 4 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.12941792 |
| 5 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 3.07305883 |
| 6 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.61495662 |
| 7 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.57069754 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.44696986 |
| 9 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.24200888 |
| 10 | Ether lipid metabolism_Homo sapiens_hsa00565 | 2.14031200 |
| 11 | Histidine metabolism_Homo sapiens_hsa00340 | 2.12700488 |
| 12 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.90747319 |
| 13 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.79500181 |
| 14 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.78916551 |
| 15 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.72001501 |
| 16 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.67909200 |
| 17 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.61743140 |
| 18 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.57662820 |
| 19 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.56029846 |
| 20 | Adherens junction_Homo sapiens_hsa04520 | 1.54077342 |
| 21 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.41455928 |
| 22 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.37338531 |
| 23 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.32288228 |
| 24 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.31859965 |
| 25 | Tight junction_Homo sapiens_hsa04530 | 1.31656458 |
| 26 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.31633581 |
| 27 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.31128927 |
| 28 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.30369351 |
| 29 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.26856079 |
| 30 | Axon guidance_Homo sapiens_hsa04360 | 1.25774936 |
| 31 | Bladder cancer_Homo sapiens_hsa05219 | 1.24709023 |
| 32 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 1.23531598 |
| 33 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.22580111 |
| 34 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.18811075 |
| 35 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.13486852 |
| 36 | Retinol metabolism_Homo sapiens_hsa00830 | 1.13373130 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.10425488 |
| 38 | Melanogenesis_Homo sapiens_hsa04916 | 1.06238736 |
| 39 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.02982669 |
| 40 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.02826037 |
| 41 | Amoebiasis_Homo sapiens_hsa05146 | 1.01438206 |
| 42 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.98107994 |
| 43 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.94880495 |
| 44 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.94825442 |
| 45 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.94534452 |
| 46 | Phototransduction_Homo sapiens_hsa04744 | 0.93136560 |
| 47 | Circadian rhythm_Homo sapiens_hsa04710 | 0.92335283 |
| 48 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.91832265 |
| 49 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.90972001 |
| 50 | Renin secretion_Homo sapiens_hsa04924 | 0.90665802 |
| 51 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.90629188 |
| 52 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.86780472 |
| 53 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.86034665 |
| 54 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.84453270 |
| 55 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.83571842 |
| 56 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.82893826 |
| 57 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.82862827 |
| 58 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.82010379 |
| 59 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.81995517 |
| 60 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.80887151 |
| 61 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.80670017 |
| 62 | Long-term depression_Homo sapiens_hsa04730 | 0.79776842 |
| 63 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.79638026 |
| 64 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.77222309 |
| 65 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.77074742 |
| 66 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.75049545 |
| 67 | Endocytosis_Homo sapiens_hsa04144 | 0.74587048 |
| 68 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.74003082 |
| 69 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.73219989 |
| 70 | Platelet activation_Homo sapiens_hsa04611 | 0.73120694 |
| 71 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.72812394 |
| 72 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.71899915 |
| 73 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.71330053 |
| 74 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.70791193 |
| 75 | Thyroid cancer_Homo sapiens_hsa05216 | 0.69238166 |
| 76 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.68936537 |
| 77 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.66875364 |
| 78 | Hepatitis C_Homo sapiens_hsa05160 | 0.66143107 |
| 79 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.66004903 |
| 80 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.65875255 |
| 81 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.62895605 |
| 82 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.61318929 |
| 83 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.60606156 |
| 84 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.60561711 |
| 85 | Galactose metabolism_Homo sapiens_hsa00052 | 0.59443413 |
| 86 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.59343438 |
| 87 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.58897078 |
| 88 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.58084353 |
| 89 | Salivary secretion_Homo sapiens_hsa04970 | 0.57848985 |
| 90 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.57399469 |
| 91 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57236097 |
| 92 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.56374133 |
| 93 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.55319470 |
| 94 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.55297956 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.55185548 |
| 96 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.54229975 |
| 97 | Pertussis_Homo sapiens_hsa05133 | 0.54133830 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.51496157 |
| 99 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.51412072 |
| 100 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.50831201 |
| 101 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.50538652 |
| 102 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.50302278 |
| 103 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.49651322 |
| 104 | Focal adhesion_Homo sapiens_hsa04510 | 0.49328751 |
| 105 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.49074147 |
| 106 | Influenza A_Homo sapiens_hsa05164 | 0.48814314 |
| 107 | Endometrial cancer_Homo sapiens_hsa05213 | 0.48297756 |
| 108 | Lysosome_Homo sapiens_hsa04142 | 0.48083959 |
| 109 | Shigellosis_Homo sapiens_hsa05131 | 0.46745227 |
| 110 | Melanoma_Homo sapiens_hsa05218 | 0.46478566 |
| 111 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.45710393 |
| 112 | ABC transporters_Homo sapiens_hsa02010 | 0.45621829 |
| 113 | Prostate cancer_Homo sapiens_hsa05215 | 0.45550543 |
| 114 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.44739775 |
| 115 | Pathways in cancer_Homo sapiens_hsa05200 | 0.42381100 |
| 116 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.42350819 |
| 117 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.42343175 |
| 118 | Glioma_Homo sapiens_hsa05214 | 0.42023035 |
| 119 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.40827243 |
| 120 | Tuberculosis_Homo sapiens_hsa05152 | 0.40413845 |
| 121 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.40000026 |
| 122 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.39707606 |
| 123 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.38149448 |
| 124 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.38114145 |
| 125 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.37865774 |
| 126 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.37658985 |
| 127 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.36697638 |
| 128 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.35961673 |
| 129 | Insulin resistance_Homo sapiens_hsa04931 | 0.35683692 |
| 130 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34549567 |
| 131 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.33835677 |
| 132 | Malaria_Homo sapiens_hsa05144 | 0.33830721 |
| 133 | Mineral absorption_Homo sapiens_hsa04978 | 0.33361420 |

