LYPD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.83829125
2motile cilium assembly (GO:0044458)9.57479782
3plasma membrane fusion (GO:0045026)9.56907360
4epithelial cilium movement (GO:0003351)9.55848914
5piRNA metabolic process (GO:0034587)9.02005469
6reproduction (GO:0000003)8.72040593
7regulation of cilium movement (GO:0003352)8.55316799
8male meiosis (GO:0007140)8.13067786
9synaptonemal complex organization (GO:0070193)8.05961796
10cilium movement (GO:0003341)7.95492233
11synaptonemal complex assembly (GO:0007130)7.77081085
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.69483355
13negative regulation of inclusion body assembly (GO:0090084)7.40069325
14negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.21717198
15single fertilization (GO:0007338)7.10727028
16sperm capacitation (GO:0048240)6.92740530
17spermatogenesis (GO:0007283)6.70455612
18male gamete generation (GO:0048232)6.68023448
19organic cation transport (GO:0015695)6.31755821
20fertilization (GO:0009566)6.25423924
21gamete generation (GO:0007276)6.13514912
22regulation of inclusion body assembly (GO:0090083)6.04015411
23regulation of retinoic acid receptor signaling pathway (GO:0048385)6.00009038
24microtubule depolymerization (GO:0007019)5.96356748
25DNA methylation involved in gamete generation (GO:0043046)5.79673969
26male meiosis I (GO:0007141)5.73378496
27germ cell development (GO:0007281)5.58661737
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.47529083
29chromosome organization involved in meiosis (GO:0070192)5.33773515
30calcium ion-dependent exocytosis (GO:0017156)5.31692833
31ventricular system development (GO:0021591)5.15569219
32seminiferous tubule development (GO:0072520)5.11833276
33behavioral response to nicotine (GO:0035095)5.09377424
34regulation of microtubule-based movement (GO:0060632)5.07181851
35chromosome condensation (GO:0030261)5.03764032
36cell recognition (GO:0008037)4.88666501
37meiotic nuclear division (GO:0007126)4.87168882
38DNA packaging (GO:0006323)4.85721096
39multicellular organismal reproductive process (GO:0048609)4.81701428
40microtubule severing (GO:0051013)4.77234449
41meiosis I (GO:0007127)4.62049028
42left/right pattern formation (GO:0060972)4.51909626
43glycerol ether metabolic process (GO:0006662)4.40992509
44spermatid nucleus differentiation (GO:0007289)4.40562503
45DNA deamination (GO:0045006)4.38941986
46chaperone-mediated protein complex assembly (GO:0051131)4.12798151
47meiotic cell cycle (GO:0051321)4.10560690
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10150087
49mitochondrial respiratory chain complex I assembly (GO:0032981)4.10150087
50NADH dehydrogenase complex assembly (GO:0010257)4.10150087
51ether metabolic process (GO:0018904)4.07279452
52regulation of female receptivity (GO:0045924)3.90728601
53multicellular organismal development (GO:0007275)3.89529283
54sulfation (GO:0051923)3.87752187
55protein localization to cilium (GO:0061512)3.83254668
56cell proliferation in forebrain (GO:0021846)3.81344545
57genitalia morphogenesis (GO:0035112)3.78661380
58water-soluble vitamin biosynthetic process (GO:0042364)3.74555329
59protein polyglutamylation (GO:0018095)3.70267283
60regulation of glomerulus development (GO:0090192)3.64215324
61somite development (GO:0061053)3.55841462
62sleep (GO:0030431)3.52269541
63protein complex biogenesis (GO:0070271)3.51811908
64single strand break repair (GO:0000012)3.49967702
65regulation of mesoderm development (GO:2000380)3.46194552
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.45146146
67regulation of spindle checkpoint (GO:0090231)3.44243622
68sexual reproduction (GO:0019953)3.43696652
69regulation of acrosome reaction (GO:0060046)3.40410769
70amino-acid betaine transport (GO:0015838)3.36880554
71carnitine transport (GO:0015879)3.36880554
72protein refolding (GO:0042026)3.36584628
73monoubiquitinated protein deubiquitination (GO:0035520)3.29985265
74negative regulation of mast cell activation (GO:0033004)3.28878958
75mitochondrial respiratory chain complex assembly (GO:0033108)3.27834511
76gene silencing by RNA (GO:0031047)3.27632774
77carnitine transmembrane transport (GO:1902603)3.26581180
78endoderm formation (GO:0001706)3.26443403
79sequestering of actin monomers (GO:0042989)3.22845785
80response to pheromone (GO:0019236)3.22154627
81female mating behavior (GO:0060180)3.21978595
82mitotic sister chromatid cohesion (GO:0007064)3.20823114
83meiotic cell cycle process (GO:1903046)3.19526606
84positive regulation of meiosis (GO:0045836)3.19152527
85cellular response to ATP (GO:0071318)3.13982149
86synapsis (GO:0007129)3.13309464
87pharyngeal system development (GO:0060037)3.10558635
88intraciliary transport (GO:0042073)3.09190552
89positive regulation of meiotic cell cycle (GO:0051446)3.07370070
90axoneme assembly (GO:0035082)3.06189906
91nucleus organization (GO:0006997)3.06158006
92centriole replication (GO:0007099)3.05018174
93interferon-gamma secretion (GO:0072643)3.03141544
94microtubule polymerization or depolymerization (GO:0031109)3.01171855
95glycolytic process (GO:0006096)2.98226150
96negative regulation of organelle assembly (GO:1902116)2.97320313
97indolalkylamine metabolic process (GO:0006586)2.94554938
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94059067
99protein K11-linked deubiquitination (GO:0035871)2.93556538
100microtubule-based movement (GO:0007018)2.91317592
101regulation of female gonad development (GO:2000194)2.90837687
102positive regulation of prostaglandin secretion (GO:0032308)2.89549632
103polyol catabolic process (GO:0046174)2.88641790
104nucleoside diphosphate phosphorylation (GO:0006165)2.88623570
105positive regulation of glomerulus development (GO:0090193)2.88535155
106positive regulation of fatty acid transport (GO:2000193)2.88368965
107alditol metabolic process (GO:0019400)2.87909633
108cilium organization (GO:0044782)2.84605025
109RNA localization (GO:0006403)2.83844334
110negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82930467
111positive regulation of cAMP-mediated signaling (GO:0043950)2.81388450
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78839813
113branching involved in labyrinthine layer morphogenesis (GO:0060670)2.78198337
114tryptophan catabolic process (GO:0006569)2.77581406
115indole-containing compound catabolic process (GO:0042436)2.77581406
116indolalkylamine catabolic process (GO:0046218)2.77581406
117lactate metabolic process (GO:0006089)2.75629454
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.74991262
119kynurenine metabolic process (GO:0070189)2.74941462
120cilium morphogenesis (GO:0060271)2.73505001
121regulation of cell proliferation involved in kidney development (GO:1901722)2.72387106
122prostate gland growth (GO:0060736)2.71710441
123gene silencing (GO:0016458)2.71389989
124cilium assembly (GO:0042384)2.69803434
125positive regulation of macrophage activation (GO:0043032)2.68301679
126cellular component assembly involved in morphogenesis (GO:0010927)2.68297565
127regulation of cilium assembly (GO:1902017)2.67023132
128peptidyl-glutamic acid modification (GO:0018200)2.66438650
129artery development (GO:0060840)2.65934942
130negative regulation of astrocyte differentiation (GO:0048712)2.64918423
131negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62994152
132mesonephros development (GO:0001823)2.62760167
133regulation of meiosis I (GO:0060631)2.62713874
134rRNA modification (GO:0000154)2.62178723
135positive regulation of fatty acid oxidation (GO:0046321)2.61613871
136phosphatidylethanolamine biosynthetic process (GO:0006646)2.61416397
137RNA destabilization (GO:0050779)2.61200438
138negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60738879
139regulation of sequestering of triglyceride (GO:0010889)2.60399353
140response to UV-C (GO:0010225)2.60311198
141positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58315757
142regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56862130
143regulation of receptor binding (GO:1900120)2.56550449
144rRNA methylation (GO:0031167)2.56508258
145protein K6-linked ubiquitination (GO:0085020)2.56367331
146mitochondrion morphogenesis (GO:0070584)2.56065359
147positive regulation of icosanoid secretion (GO:0032305)2.55929989
148lung-associated mesenchyme development (GO:0060484)2.55063201
149phosphatidylethanolamine metabolic process (GO:0046337)2.54809128
150response to xenobiotic stimulus (GO:0009410)2.53948743
151detection of light stimulus involved in sensory perception (GO:0050962)2.53645658
152detection of light stimulus involved in visual perception (GO:0050908)2.53645658
153regulation of action potential (GO:0098900)2.51395788
154GTP biosynthetic process (GO:0006183)2.50443796
155primary amino compound metabolic process (GO:1901160)2.49691068
156histone H3-K9 demethylation (GO:0033169)2.49690451
157nuclear pore complex assembly (GO:0051292)2.47376628
158regulation of centriole replication (GO:0046599)2.44260152
159sperm motility (GO:0030317)13.4749152
160fusion of sperm to egg plasma membrane (GO:0007342)12.5840187
161acrosome reaction (GO:0007340)11.9144231
162sperm-egg recognition (GO:0035036)11.3162472
163cell wall macromolecule metabolic process (GO:0044036)11.3017742
164cell wall macromolecule catabolic process (GO:0016998)11.3017742
165acrosome assembly (GO:0001675)11.2320531
166cilium or flagellum-dependent cell motility (GO:0001539)10.7757736
167binding of sperm to zona pellucida (GO:0007339)10.4552797
168multicellular organism reproduction (GO:0032504)10.2299600
169axonemal dynein complex assembly (GO:0070286)10.1662448
170cell-cell recognition (GO:0009988)10.1217731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95819417
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.03603869
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.01453076
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07331650
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.96555450
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.72010121
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57791995
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50863750
9GBX2_23144817_ChIP-Seq_PC3_Human2.48373124
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.38005382
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33858259
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.30903833
13VDR_22108803_ChIP-Seq_LS180_Human2.29767701
14IRF1_19129219_ChIP-ChIP_H3396_Human2.29073703
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28079087
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.24469381
17ZNF274_21170338_ChIP-Seq_K562_Hela2.14093885
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09763728
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06676153
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00832159
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.5205467
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.96014133
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90155795
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.86906631
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.80541867
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78188765
27FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77204200
28MYC_18940864_ChIP-ChIP_HL60_Human1.76071108
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.72916525
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.66182271
31FUS_26573619_Chip-Seq_HEK293_Human1.65812483
32STAT1_17558387_ChIP-Seq_HELA_Human1.63580077
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62874562
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.61051529
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59878163
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59678982
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59008278
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56347988
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53189795
40GATA3_21867929_ChIP-Seq_CD8_Mouse1.52088437
41P300_19829295_ChIP-Seq_ESCs_Human1.51636403
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.51590590
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51542381
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.51038936
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50494040
46RNF2_27304074_Chip-Seq_NSC_Mouse1.49166058
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49012151
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46887803
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.46168573
50FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44733961
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44593168
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.39841531
53IGF1R_20145208_ChIP-Seq_DFB_Human1.39459791
54ER_23166858_ChIP-Seq_MCF-7_Human1.38933429
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36823123
56CBP_20019798_ChIP-Seq_JUKART_Human1.36823123
57NCOR_22424771_ChIP-Seq_293T_Human1.34552707
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.33232973
59P53_21459846_ChIP-Seq_SAOS-2_Human1.31627728
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31467548
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31057190
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30689673
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.30537635
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29971746
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29964126
66TAF15_26573619_Chip-Seq_HEK293_Human1.29957354
67KDM2B_26808549_Chip-Seq_REH_Human1.28935790
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28797986
69REST_21632747_ChIP-Seq_MESCs_Mouse1.28569074
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27555654
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27393155
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.26929345
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.25141166
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24029487
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23458214
76EWS_26573619_Chip-Seq_HEK293_Human1.23429216
77AR_25329375_ChIP-Seq_VCAP_Human1.23374796
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22688630
79SMAD4_21799915_ChIP-Seq_A2780_Human1.21909349
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20745949
81TP53_22573176_ChIP-Seq_HFKS_Human1.20358464
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20124292
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19075442
84SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17765134
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.17616934
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16848464
87ERA_21632823_ChIP-Seq_H3396_Human1.16328643
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.15887073
89GF1_26923725_Chip-Seq_HPCs_Mouse1.15640405
90BCAT_22108803_ChIP-Seq_LS180_Human1.15537083
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.14290260
92* TCF4_23295773_ChIP-Seq_U87_Human1.14185652
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.12778025
94CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12650877
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11986333
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.11986333
97STAT3_23295773_ChIP-Seq_U87_Human1.11099143
98TAF2_19829295_ChIP-Seq_ESCs_Human1.10624532
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.10465520
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10296194
101RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10227909
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09365382
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09102748
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09036697
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09036697
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.09029047
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08980159
108SPI1_26923725_Chip-Seq_HPCs_Mouse1.08956689
109* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08730201
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08552082
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08387694
112MYC_27129775_Chip-Seq_CORNEA_Mouse1.07760130
113LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07604894
114ERG_20517297_ChIP-Seq_VCAP_Human1.07484019
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07357029
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06895119
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06145716
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05946617
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05888751
120TET1_21451524_ChIP-Seq_MESCs_Mouse1.05396218
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05145242
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04697217
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04338741
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04066614
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03443734
126RUNX2_22187159_ChIP-Seq_PCA_Human1.03430879
127HOXB7_26014856_ChIP-Seq_BT474_Human1.03123244
128MYC_19829295_ChIP-Seq_ESCs_Human1.02672220
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02243971
130RARA_24833708_ChIP-Seq_LIVER_Mouse1.02045309
131SOX2_19829295_ChIP-Seq_ESCs_Human1.01832093
132NANOG_19829295_ChIP-Seq_ESCs_Human1.01832093
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01367402
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00488895
135FOXH1_21741376_ChIP-Seq_EPCs_Human1.00460036
136ESET_19884257_ChIP-Seq_ESCs_Mouse1.00450428
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00267799
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99903294
139TP53_20018659_ChIP-ChIP_R1E_Mouse0.99866459
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99603620
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99515885
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99496189
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99496189
144RAC3_21632823_ChIP-Seq_H3396_Human0.99311247
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99151008
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.99018265
147GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98640847
148CTCF_20526341_ChIP-Seq_ESCs_Human0.98411825
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98094116
150SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97775021
151SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97395422
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.97237500
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96302272
154EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96067168
155ETV1_20927104_ChIP-Seq_GIST48_Human0.95923064
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.95221245
157CRX_20693478_ChIP-Seq_RETINA_Mouse0.94367819
158LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94228472
159JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92593440
160SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92303411
161FLI1_21867929_ChIP-Seq_CD8_Mouse0.91289405
162SOX2_21211035_ChIP-Seq_LN229_Human0.91090781
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90309087
164NANOG_18555785_Chip-Seq_ESCs_Mouse0.87396285
165BCOR_27268052_Chip-Seq_Bcells_Human0.86972757
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86967520
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86469915
168NANOG_20526341_ChIP-Seq_ESCs_Human0.85686219
169PHF8_20622854_ChIP-Seq_HELA_Human0.85178507
170NFYB_21822215_ChIP-Seq_K562_Human0.85111987
171NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85028268
172OCT4_18555785_Chip-Seq_ESCs_Mouse0.84951855
173NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84662226
174CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83564373
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82906585
176RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82255494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05058534
2MP0001929_abnormal_gametogenesis5.58640183
3MP0008877_abnormal_DNA_methylation4.73939651
4MP0006292_abnormal_olfactory_placode3.93342741
5MP0002210_abnormal_sex_determination3.59304382
6MP0005646_abnormal_pituitary_gland3.36883122
7MP0002161_abnormal_fertility/fecundity3.29480993
8MP0001145_abnormal_male_reproductive3.03714407
9MP0000653_abnormal_sex_gland2.61928660
10MP0005670_abnormal_white_adipose2.57811989
11MP0002653_abnormal_ependyma_morphology2.49097175
12MP0004885_abnormal_endolymph2.31327200
13MP0002138_abnormal_hepatobiliary_system2.27524231
14MP0000049_abnormal_middle_ear2.26743135
15MP0003283_abnormal_digestive_organ2.24918782
16MP0001485_abnormal_pinna_reflex2.19855835
17MP0005410_abnormal_fertilization16.1664026
18MP0000678_abnormal_parathyroid_gland1.94898756
19MP0006072_abnormal_retinal_apoptosis1.93673968
20MP0002876_abnormal_thyroid_physiology1.93188531
21MP0002160_abnormal_reproductive_system1.85641144
22MP0001968_abnormal_touch/_nociception1.84350048
23MP0003718_maternal_effect1.76649352
24MP0003119_abnormal_digestive_system1.75841211
25MP0009379_abnormal_foot_pigmentation1.71561803
26MP0000631_abnormal_neuroendocrine_gland1.71125300
27MP0003646_muscle_fatigue1.69188439
28MP0001986_abnormal_taste_sensitivity1.68996539
29MP0002272_abnormal_nervous_system1.65650080
30MP0009053_abnormal_anal_canal1.58626233
31MP0003724_increased_susceptibility_to1.57672488
32MP0002837_dystrophic_cardiac_calcinosis1.57050423
33MP0004142_abnormal_muscle_tone1.55298150
34MP0003195_calcinosis1.52217304
35MP0005623_abnormal_meninges_morphology1.49764560
36MP0009745_abnormal_behavioral_response1.45979642
37MP0004233_abnormal_muscle_weight1.42341645
38MP0001440_abnormal_grooming_behavior1.40598752
39MP0008872_abnormal_physiological_respon1.38911102
40MP0004145_abnormal_muscle_electrophysio1.38291789
41MP0003938_abnormal_ear_development1.34537443
42MP0008789_abnormal_olfactory_epithelium1.33771081
43MP0003693_abnormal_embryo_hatching1.33763849
44MP0005379_endocrine/exocrine_gland_phen1.28111750
45MP0002735_abnormal_chemical_nociception1.26225897
46MP0002163_abnormal_gland_morphology1.22934332
47MP0001963_abnormal_hearing_physiology1.19136032
48MP0002282_abnormal_trachea_morphology1.18009588
49MP0001502_abnormal_circadian_rhythm1.17778493
50MP0006276_abnormal_autonomic_nervous1.13225797
51MP0000026_abnormal_inner_ear1.11354570
52MP0001486_abnormal_startle_reflex1.11233135
53MP0004130_abnormal_muscle_cell1.10706626
54MP0001984_abnormal_olfaction1.09010834
55MP0005423_abnormal_somatic_nervous1.08733320
56MP0002277_abnormal_respiratory_mucosa1.07425434
57MP0005360_urolithiasis1.01231059
58MP0001919_abnormal_reproductive_system1.00395672
59MP0003937_abnormal_limbs/digits/tail_de0.98099825
60MP0005671_abnormal_response_to0.97955605
61MP0001765_abnormal_ion_homeostasis0.97945944
62MP0002734_abnormal_mechanical_nocicepti0.96479766
63MP0008058_abnormal_DNA_repair0.93576739
64MP0005647_abnormal_sex_gland0.93273386
65MP0005389_reproductive_system_phenotype0.91135644
66MP0008995_early_reproductive_senescence0.87774841
67MP0002249_abnormal_larynx_morphology0.87440605
68MP0000013_abnormal_adipose_tissue0.86907242
69MP0002557_abnormal_social/conspecific_i0.86707597
70MP0003136_yellow_coat_color0.86622093
71MP0001905_abnormal_dopamine_level0.86329984
72MP0009250_abnormal_appendicular_skeleto0.86057005
73MP0002234_abnormal_pharynx_morphology0.85092527
74MP0003638_abnormal_response/metabolism_0.85084656
75MP0002064_seizures0.84770808
76MP0000230_abnormal_systemic_arterial0.83829660
77MP0002733_abnormal_thermal_nociception0.83297920
78MP0002751_abnormal_autonomic_nervous0.82921037
79MP0002572_abnormal_emotion/affect_behav0.82836475
80MP0003011_delayed_dark_adaptation0.82611537
81MP0005195_abnormal_posterior_eye0.80725212
82MP0003635_abnormal_synaptic_transmissio0.80365392
83MP0001970_abnormal_pain_threshold0.79990517
84MP0005499_abnormal_olfactory_system0.79691738
85MP0005394_taste/olfaction_phenotype0.79691738
86MP0005174_abnormal_tail_pigmentation0.79210851
87MP0005645_abnormal_hypothalamus_physiol0.79062405
88MP0000516_abnormal_urinary_system0.78963266
89MP0005367_renal/urinary_system_phenotyp0.78963266
90MP0009765_abnormal_xenobiotic_induced0.78435488
91MP0009046_muscle_twitch0.77318357
92MP0000372_irregular_coat_pigmentation0.75959858
93MP0003115_abnormal_respiratory_system0.75055550
94MP0008057_abnormal_DNA_replication0.74520944
95MP0001501_abnormal_sleep_pattern0.72540532
96MP0010094_abnormal_chromosome_stability0.71795192
97MP0005377_hearing/vestibular/ear_phenot0.69515415
98MP0003878_abnormal_ear_physiology0.69515415
99MP0003329_amyloid_beta_deposits0.60898921
100MP0000569_abnormal_digit_pigmentation0.60295049
101MP0009278_abnormal_bone_marrow0.57949069
102MP0000358_abnormal_cell_content/0.56682074
103MP0005397_hematopoietic_system_phenotyp0.55275403
104MP0001545_abnormal_hematopoietic_system0.55275403
105MP0005666_abnormal_adipose_tissue0.55225768
106MP0005636_abnormal_mineral_homeostasis0.51662005
107MP0003699_abnormal_female_reproductive0.48048857
108MP0003786_premature_aging0.47857691
109MP0004036_abnormal_muscle_relaxation0.46630826
110MP0008007_abnormal_cellular_replicative0.46500076
111MP0001324_abnormal_eye_pigmentation0.45064216
112MP0003111_abnormal_nucleus_morphology0.44652820
113MP0002269_muscular_atrophy0.44075246
114MP0001293_anophthalmia0.44020824
115MP0002928_abnormal_bile_duct0.41903944
116MP0006036_abnormal_mitochondrial_physio0.41550936
117MP0003950_abnormal_plasma_membrane0.40878129
118MP0001764_abnormal_homeostasis0.39910790
119MP0000534_abnormal_ureter_morphology0.38040684
120MP0001730_embryonic_growth_arrest0.37420932
121MP0005253_abnormal_eye_physiology0.36224166
122MP0005551_abnormal_eye_electrophysiolog0.32572480
123MP0004808_abnormal_hematopoietic_stem0.32363925
124MP0009115_abnormal_fat_cell0.32362401
125MP0005391_vision/eye_phenotype0.30632640
126MP0003942_abnormal_urinary_system0.30574523
127MP0001119_abnormal_female_reproductive0.30501508
128MP0000604_amyloidosis0.30169101
129MP0004811_abnormal_neuron_physiology0.28834437
130MP0002971_abnormal_brown_adipose0.28662594
131MP0010307_abnormal_tumor_latency0.27751427
132MP0003879_abnormal_hair_cell0.27644696
133MP0002736_abnormal_nociception_after0.27593008
134MP0004133_heterotaxia0.27412923
135MP0001661_extended_life_span0.27145506
136MP0003861_abnormal_nervous_system0.27100831
137MP0008961_abnormal_basal_metabolism0.24756010
138MP0002152_abnormal_brain_morphology0.23817787
139MP0001727_abnormal_embryo_implantation0.23817101
140MP0003633_abnormal_nervous_system0.23518156
141MP0000751_myopathy0.22377102
142MP0006035_abnormal_mitochondrial_morpho0.22315652
143MP0004019_abnormal_vitamin_homeostasis0.21046398
144MP0000313_abnormal_cell_death0.20817156
145MP0002169_no_abnormal_phenotype0.20502231
146MP0003948_abnormal_gas_homeostasis0.20437162
147MP0002873_normal_phenotype0.20252677
148MP0003045_fibrosis0.19944675
149MP0003631_nervous_system_phenotype0.19788315
150MP0002092_abnormal_eye_morphology0.19621920
151MP0002084_abnormal_developmental_patter0.19039406
152MP0002295_abnormal_pulmonary_circulatio0.18547002
153MP0004134_abnormal_chest_morphology0.18478553
154MP0001849_ear_inflammation0.17182824
155MP0002139_abnormal_hepatobiliary_system0.16355774
156MP0005375_adipose_tissue_phenotype0.16340745
157MP0003787_abnormal_imprinting0.15934702
158MP0005380_embryogenesis_phenotype0.15085826
159MP0001672_abnormal_embryogenesis/_devel0.15085826
160MP0004043_abnormal_pH_regulation0.15063283
161MP0003936_abnormal_reproductive_system0.14924956
162MP0003077_abnormal_cell_cycle0.14896324
163MP0004742_abnormal_vestibular_system0.14832494
164MP0001697_abnormal_embryo_size0.14067771
165MP0002229_neurodegeneration0.13943986
166MP0000001_mammalian_phenotype0.13848908
167MP0002108_abnormal_muscle_morphology0.12903901
168MP0002102_abnormal_ear_morphology0.11387284
169MP0003959_abnormal_lean_body0.10937524

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.24051112
2Abnormal respiratory motile cilium morphology (HP:0005938)9.01103525
3Abnormal respiratory epithelium morphology (HP:0012253)9.01103525
4Rhinitis (HP:0012384)7.75948982
5Chronic bronchitis (HP:0004469)7.33233918
6Abnormal ciliary motility (HP:0012262)7.10782295
7Infertility (HP:0000789)7.01194518
8Nasal polyposis (HP:0100582)6.52155953
9Abnormality of the nasal mucosa (HP:0000433)5.35931630
10Bronchitis (HP:0012387)4.59272662
11Bronchiectasis (HP:0002110)4.55111487
12Nephronophthisis (HP:0000090)4.41993266
13Male infertility (HP:0003251)4.37447916
14Short 1st metacarpal (HP:0010034)3.84413164
15Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.84413164
16Abnormal spermatogenesis (HP:0008669)3.52209073
17Pendular nystagmus (HP:0012043)3.43631525
18Abnormality of the 1st metacarpal (HP:0010009)3.37088362
19Abnormality of the renal medulla (HP:0100957)3.32450275
20Recurrent otitis media (HP:0000403)3.32204008
21Abnormality of the nasal septum (HP:0000419)3.16017333
22Recurrent sinusitis (HP:0011108)3.07306810
23Pancreatic cysts (HP:0001737)3.04881706
24Abnormality of the proximal phalanges of the hand (HP:0009834)3.04002841
25Stenosis of the external auditory canal (HP:0000402)3.00527860
26Abnormal rod and cone electroretinograms (HP:0008323)3.00255245
27Congenital stationary night blindness (HP:0007642)2.95160932
28Gonadotropin excess (HP:0000837)2.94616328
29Abolished electroretinogram (ERG) (HP:0000550)2.93448659
30Congenital sensorineural hearing impairment (HP:0008527)2.91279428
31Absent thumb (HP:0009777)2.89504490
32Pancreatic fibrosis (HP:0100732)2.86935862
33Short tibia (HP:0005736)2.85375296
34Tubulointerstitial nephritis (HP:0001970)2.83595687
35Short hallux (HP:0010109)2.77694343
36Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.76675628
37Recurrent bronchitis (HP:0002837)2.76631825
38Impulsivity (HP:0100710)2.75660950
39Bony spicule pigmentary retinopathy (HP:0007737)2.75453765
40Short phalanx of the thumb (HP:0009660)2.75350673
41Tubular atrophy (HP:0000092)2.72150649
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.70957079
43Aplasia/Hypoplasia of the hallux (HP:0008362)2.70423489
44Severe visual impairment (HP:0001141)2.66461794
45Attenuation of retinal blood vessels (HP:0007843)2.65077188
46Ectopic kidney (HP:0000086)2.64827351
47Molar tooth sign on MRI (HP:0002419)2.61349507
48Abnormality of midbrain morphology (HP:0002418)2.61349507
49Abnormality of the middle phalanges of the toes (HP:0010183)2.61159341
50Congenital, generalized hypertrichosis (HP:0004540)2.59727377
51Abnormality of the renal collecting system (HP:0004742)2.59510092
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59190604
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.56656677
54Abnormality of the lower motor neuron (HP:0002366)2.56349488
55Tubulointerstitial abnormality (HP:0001969)2.53269716
56True hermaphroditism (HP:0010459)2.52459537
57Abnormality of DNA repair (HP:0003254)2.50799946
58Carpal bone hypoplasia (HP:0001498)2.49426764
59Hypoplasia of the uterus (HP:0000013)2.48549514
60Synostosis of carpal bones (HP:0005048)2.47783872
61Progressive cerebellar ataxia (HP:0002073)2.44242834
62Type II lissencephaly (HP:0007260)2.42249356
63Azoospermia (HP:0000027)2.42175220
64Medial flaring of the eyebrow (HP:0010747)2.40457814
65Fused cervical vertebrae (HP:0002949)2.39274622
66Aplasia/hypoplasia of the uterus (HP:0008684)2.38167229
67Maternal diabetes (HP:0009800)2.36923436
68Methylmalonic acidemia (HP:0002912)2.32970380
69Abnormal gallbladder physiology (HP:0012438)2.27477122
70Cholecystitis (HP:0001082)2.27477122
71Increased corneal curvature (HP:0100692)2.24769849
72Keratoconus (HP:0000563)2.24769849
73Acute necrotizing encephalopathy (HP:0006965)2.22942183
743-Methylglutaconic aciduria (HP:0003535)2.22610104
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21973177
76Symphalangism affecting the phalanges of the hand (HP:0009773)2.20355825
77Morphological abnormality of the middle ear (HP:0008609)2.19053968
78Genetic anticipation (HP:0003743)2.18821513
79Abnormality of alanine metabolism (HP:0010916)2.13241251
80Hyperalaninemia (HP:0003348)2.13241251
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13241251
82Tubulointerstitial fibrosis (HP:0005576)2.12767501
83Chorioretinal atrophy (HP:0000533)2.10992990
84Amyotrophic lateral sclerosis (HP:0007354)2.10039241
85Porencephaly (HP:0002132)2.09997704
86Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.06496855
87Humeroradial synostosis (HP:0003041)2.06316497
88Synostosis involving the elbow (HP:0003938)2.06316497
89IgG deficiency (HP:0004315)2.06007720
90Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.03433994
91Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01907020
92Asplenia (HP:0001746)2.00983971
93Spastic tetraparesis (HP:0001285)2.00058570
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1405133
95Dynein arm defect of respiratory motile cilia (HP:0012255)12.9504396
96Absent/shortened dynein arms (HP:0200106)12.9504396
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97823809
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.97653524
99Abnormal mitochondria in muscle tissue (HP:0008316)1.97094153
100Fibular hypoplasia (HP:0003038)1.96118645
101Sclerocornea (HP:0000647)1.95027858
102Horseshoe kidney (HP:0000085)1.94317245
103Postaxial foot polydactyly (HP:0001830)1.94231078
104Aplasia/Hypoplasia involving the musculature (HP:0001460)1.93639652
105Abnormality of the costochondral junction (HP:0000919)1.93598321
106Stage 5 chronic kidney disease (HP:0003774)1.92875393
107Decreased subcutaneous fat (HP:0001002)1.90987267
108Polydipsia (HP:0001959)1.90931529
109Abnormal drinking behavior (HP:0030082)1.90931529
110Dyschromatopsia (HP:0007641)1.90890368
111Mitochondrial inheritance (HP:0001427)1.90743111
112Agitation (HP:0000713)1.90664669
113Prostate neoplasm (HP:0100787)1.89778109
114Methylmalonic aciduria (HP:0012120)1.89099689
115Progressive macrocephaly (HP:0004481)1.86832876
116Concave nail (HP:0001598)1.86509495
117Hypoplasia of the ulna (HP:0003022)1.84607875
118Gaze-evoked nystagmus (HP:0000640)1.82865628
119Abnormal number of incisors (HP:0011064)1.82196618
120Chronic hepatic failure (HP:0100626)1.81969853
121Duplicated collecting system (HP:0000081)1.81910899
122Osteomalacia (HP:0002749)1.80678961
123Choroideremia (HP:0001139)1.79931153
124Adrenal hypoplasia (HP:0000835)1.79680253
125Confusion (HP:0001289)1.79173497
126Congenital hepatic fibrosis (HP:0002612)1.78714164
127Absent phalangeal crease (HP:0006109)1.78024748
128Optic nerve hypoplasia (HP:0000609)1.77941368
129Increased CSF lactate (HP:0002490)1.77073478
130Heterotopia (HP:0002282)1.75279013
131Reticulocytopenia (HP:0001896)1.75141797
132Impaired proprioception (HP:0010831)1.74947544
133Acute encephalopathy (HP:0006846)1.74758607
134Short ribs (HP:0000773)1.73481472
135Abnormality of the renal cortex (HP:0011035)1.72625091
136Oculomotor apraxia (HP:0000657)1.68239080
137Renal dysplasia (HP:0000110)1.65481786
138Bell-shaped thorax (HP:0001591)1.62521241
139Abnormality of renal excretion (HP:0011036)1.62420809
140Abnormality of dentin (HP:0010299)1.59939497
141Decreased central vision (HP:0007663)1.59288633
142Bile duct proliferation (HP:0001408)1.56105255
143Abnormal biliary tract physiology (HP:0012439)1.56105255
144Absent epiphyses (HP:0010577)1.55775124
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55775124
146Neurofibrillary tangles (HP:0002185)1.55556774
147Facial cleft (HP:0002006)1.51042183
148Abnormality of the dental root (HP:0006486)1.50702259
149Taurodontia (HP:0000679)1.50702259
150Abnormality of permanent molar morphology (HP:0011071)1.50702259
151Postaxial hand polydactyly (HP:0001162)1.49697779
152Hemorrhage of the eye (HP:0011885)1.49515046
153Absent frontal sinuses (HP:0002688)1.45607490
154Deformed sella turcica (HP:0002681)1.44145970
155Aplasia/Hypoplasia of the lens (HP:0008063)1.40190996
156Abnormality of the dental pulp (HP:0006479)1.39868198
157Abnormality of molar morphology (HP:0011070)1.38919363
158Abnormality of molar (HP:0011077)1.38919363
159Abnormal urine output (HP:0012590)1.38906056
160Chronic sinusitis (HP:0011109)1.38255694
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.37356430
162Broad distal phalanx of finger (HP:0009836)1.36588151
163J-shaped sella turcica (HP:0002680)1.36481032
164Decreased electroretinogram (ERG) amplitude (HP:0000654)1.36137236
165Congenital malformation of the right heart (HP:0011723)1.35667745
166Double outlet right ventricle (HP:0001719)1.35667745
167Cerebellar dysplasia (HP:0007033)1.35118841
168Upper motor neuron abnormality (HP:0002127)1.33756856
169Short thorax (HP:0010306)1.33519699
170Exercise-induced myalgia (HP:0003738)1.33085158
171Microglossia (HP:0000171)1.32017470
172Cystic liver disease (HP:0006706)1.31220927
173Easy fatigability (HP:0003388)1.30928087
174Supernumerary spleens (HP:0009799)1.29640723
175Nephropathy (HP:0000112)1.29439698
176Short femoral neck (HP:0100864)1.28501780
177Loss of speech (HP:0002371)1.27637433
178Cerebral inclusion bodies (HP:0100314)1.24341384
179Hemiparesis (HP:0001269)1.23350729
180Abnormality of ocular smooth pursuit (HP:0000617)1.22776274
181Polyuria (HP:0000103)1.21019210
182Median cleft lip (HP:0000161)1.19854463
183Bundle branch block (HP:0011710)1.18951790
184Abnormality of the anterior horn cell (HP:0006802)1.18547257
185Degeneration of anterior horn cells (HP:0002398)1.18547257
186Congenital primary aphakia (HP:0007707)1.18506223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.10068275
2PDK38.10068275
3TESK16.36044303
4PDK25.23302047
5PRKD35.07388967
6ICK4.53383176
7TAOK34.03525560
8TLK13.81830804
9GRK13.51308814
10ADRBK23.05755778
11ZAK3.00955696
12MAP4K22.84948113
13TXK2.80811027
14FRK2.78303088
15STK162.56767474
16PTK2B2.43070736
17NUAK12.37254250
18MAP2K22.33411254
19WNK42.29379250
20STK392.19255517
21PNCK2.04378205
22NEK21.89463795
23STK381.86385880
24INSRR1.68358782
25PLK21.58020421
26ACVR1B1.55441496
27DYRK1B1.45996619
28VRK11.41121796
29OXSR11.33827055
30GRK61.21074724
31GRK71.16559231
32IKBKB1.13154315
33CDK191.13089106
34MAP3K91.12820941
35PDK11.10225347
36TIE11.09812088
37MAPK151.04640028
38MAPK131.00843394
39MAP2K10.99564993
40WNK10.96374278
41TYRO30.95401056
42DYRK30.87210677
43GRK50.87083739
44TNIK0.86489154
45DYRK20.83445769
46PASK0.82742508
47PRKD20.82227254
48VRK20.81127220
49CCNB10.80197904
50STK30.78401568
51CDK90.74944498
52PHKG10.71366213
53PHKG20.71366213
54ADRBK10.70589106
55RPS6KA50.70438833
56IRAK10.67733077
57PINK10.66263652
58TTK0.65879360
59CSNK1G20.65075378
60PDPK10.64845662
61BCKDK0.64166890
62EEF2K0.63761662
63CSNK1G10.63653012
64NTRK30.60901345
65TESK20.59483101
66PRKCE0.59197038
67PKN10.57676052
68CSNK1G30.56292482
69TEC0.55512313
70CDK80.55053502
71PRKACA0.53855298
72CHEK20.53596249
73PRKCI0.53466765
74RIPK40.52937834
75IKBKE0.51261427
76CAMK1G0.50755949
77MAP3K130.50464385
78IGF1R0.49364315
79RPS6KA60.47781129
80CSNK1A10.47414723
81KIT0.46553349
82CDC70.46001718
83CHEK10.42869507
84NTRK20.42670736
85TRIM280.40062563
86DAPK20.39548509
87LMTK20.38642299
88MUSK0.38638420
89ARAF0.37141738
90WEE10.37093740
91ATR0.36871386
92MAP2K60.36269068
93PAK10.36051494
94STK38L0.35195206
95BUB10.35095545
96SGK10.34219756
97IRAK20.33976022
98CHUK0.33848652
99CDK30.32920510
100TGFBR10.32850987
101SGK2230.32511712
102SGK4940.32511712
103PRKCG0.32194202
104CAMK10.30910155
105AURKB0.30470474
106MTOR0.30419573
107CASK0.30418596
108LYN0.30411098
109ATM0.30190486
110PAK20.28928830
111CAMKK10.26474825
112MARK20.23812381
113MAPKAPK50.23641016
114MAP3K100.22753367
115PAK40.22217101
116PRKAA10.21783501
117PLK40.17947767
118RPS6KB10.17286980
119PLK10.16203889
120PRKCZ0.14151873
121CDK120.12246790
122BMPR1B0.11198634
123CDK150.10841827
124BRSK20.10516127
125NEK60.10437596
126PRKCQ0.10366819
127BRAF0.08933884
128CDK180.08403694
129CDK11A0.07468264
130RPS6KA10.07357764
131CSF1R0.07243773
132CSNK2A10.05906252
133GSK3B0.05305944
134BRSK10.04791749
135STK110.04455592
136PAK60.04186152
137STK100.04077543
138CDK140.04074058
139WNK30.03969380
140CDK20.03467115
141CDK10.03293814
142MARK30.03185284
143MAPK80.02625618
144PRKACG0.01615583
145PRKG20.01092962
146CSNK1D0.01048130
147PRKG10.00886427
148TRIB30.00721848
149CLK10.00707936
150PRKCB0.00265292
151CDK60.00022830
152PRKCD-0.0249348
153PDGFRB-0.0247642
154CDK4-0.0226765
155AURKA-0.0226554
156ZAP70-0.0221168
157PRKCA-0.0212138
158PRKDC-0.0175481
159TAOK1-0.0173434
160PRKACB-0.0170219
161CAMK2A-0.0164558
162MAP3K4-0.0157362
163CSNK2A2-0.0103763
164PIM1-0.0067015
165EGFR-0.0060389

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.40105561
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.37934339
3Fatty acid biosynthesis_Homo sapiens_hsa000614.36252129
4Vitamin B6 metabolism_Homo sapiens_hsa007503.89448809
5Pyruvate metabolism_Homo sapiens_hsa006203.74969858
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09281375
7Linoleic acid metabolism_Homo sapiens_hsa005912.97325022
8Propanoate metabolism_Homo sapiens_hsa006402.83503839
9Glucagon signaling pathway_Homo sapiens_hsa049222.74646073
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.57449756
11Phototransduction_Homo sapiens_hsa047442.53590362
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44459954
13Basal transcription factors_Homo sapiens_hsa030222.43596134
14Ribosome_Homo sapiens_hsa030102.39559026
15Selenocompound metabolism_Homo sapiens_hsa004502.37943290
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30077173
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.21141035
18Dorso-ventral axis formation_Homo sapiens_hsa043202.13229097
19Nicotine addiction_Homo sapiens_hsa050332.12623007
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.08617090
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01366560
22Glycerolipid metabolism_Homo sapiens_hsa005612.00781651
23RNA polymerase_Homo sapiens_hsa030201.91601419
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91046102
25Oxidative phosphorylation_Homo sapiens_hsa001901.90321543
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88747402
27PPAR signaling pathway_Homo sapiens_hsa033201.80649531
28Pentose phosphate pathway_Homo sapiens_hsa000301.80498337
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80255219
30Oocyte meiosis_Homo sapiens_hsa041141.76480014
31Homologous recombination_Homo sapiens_hsa034401.73513171
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.72769623
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.69890803
34Fanconi anemia pathway_Homo sapiens_hsa034601.65244763
35Amphetamine addiction_Homo sapiens_hsa050311.63036067
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.60640054
37Fructose and mannose metabolism_Homo sapiens_hsa000511.59737563
38Olfactory transduction_Homo sapiens_hsa047401.57336751
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51294632
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50834488
41Fat digestion and absorption_Homo sapiens_hsa049751.50357181
42Parkinsons disease_Homo sapiens_hsa050121.50028029
43Nitrogen metabolism_Homo sapiens_hsa009101.49162445
44Morphine addiction_Homo sapiens_hsa050321.38440951
45Fatty acid metabolism_Homo sapiens_hsa012121.38382211
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37486739
47Ether lipid metabolism_Homo sapiens_hsa005651.36255307
48Caffeine metabolism_Homo sapiens_hsa002321.36220052
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.35315754
50Carbon metabolism_Homo sapiens_hsa012001.35115706
51Retinol metabolism_Homo sapiens_hsa008301.34327468
52Fatty acid degradation_Homo sapiens_hsa000711.32607623
53Tryptophan metabolism_Homo sapiens_hsa003801.30623859
54Cardiac muscle contraction_Homo sapiens_hsa042601.30191088
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28900090
56Regulation of autophagy_Homo sapiens_hsa041401.23717394
57Mineral absorption_Homo sapiens_hsa049781.22030378
58Huntingtons disease_Homo sapiens_hsa050161.21939115
59Asthma_Homo sapiens_hsa053101.20516765
60mRNA surveillance pathway_Homo sapiens_hsa030151.16965988
61Antigen processing and presentation_Homo sapiens_hsa046121.16666655
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16487983
63Renin secretion_Homo sapiens_hsa049241.16171057
64Primary immunodeficiency_Homo sapiens_hsa053401.11885428
65Protein export_Homo sapiens_hsa030601.09883532
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09771549
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05839737
68Glycosaminoglycan degradation_Homo sapiens_hsa005311.05740496
69RNA transport_Homo sapiens_hsa030131.00573331
70Alzheimers disease_Homo sapiens_hsa050100.98101239
71Purine metabolism_Homo sapiens_hsa002300.93051688
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92169932
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.91844056
74Glutathione metabolism_Homo sapiens_hsa004800.90466182
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90369971
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88328266
77Long-term potentiation_Homo sapiens_hsa047200.86151386
78Hedgehog signaling pathway_Homo sapiens_hsa043400.85030719
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84845465
80Graft-versus-host disease_Homo sapiens_hsa053320.83723320
81Type I diabetes mellitus_Homo sapiens_hsa049400.83689993
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80798328
83Biosynthesis of amino acids_Homo sapiens_hsa012300.80676367
84Serotonergic synapse_Homo sapiens_hsa047260.79256521
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.78703005
86Butanoate metabolism_Homo sapiens_hsa006500.77888588
87Autoimmune thyroid disease_Homo sapiens_hsa053200.77856110
88GABAergic synapse_Homo sapiens_hsa047270.77485475
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77461433
90Allograft rejection_Homo sapiens_hsa053300.77231133
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76720667
92Estrogen signaling pathway_Homo sapiens_hsa049150.76289180
93Arachidonic acid metabolism_Homo sapiens_hsa005900.75481740
94Ovarian steroidogenesis_Homo sapiens_hsa049130.73078951
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72106076
96Chemical carcinogenesis_Homo sapiens_hsa052040.71009279
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70754729
98Vitamin digestion and absorption_Homo sapiens_hsa049770.70494804
99Collecting duct acid secretion_Homo sapiens_hsa049660.69406187
100ABC transporters_Homo sapiens_hsa020100.67968040
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.67651632
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67546177
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66514954
104Systemic lupus erythematosus_Homo sapiens_hsa053220.65100494
105Insulin secretion_Homo sapiens_hsa049110.63646438
106Peroxisome_Homo sapiens_hsa041460.62944517
107Nucleotide excision repair_Homo sapiens_hsa034200.62833906
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62808459
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62569696
110Legionellosis_Homo sapiens_hsa051340.60703976
111Thyroid hormone synthesis_Homo sapiens_hsa049180.56957144
112Bile secretion_Homo sapiens_hsa049760.55949882
113Mismatch repair_Homo sapiens_hsa034300.54407631
114Glutamatergic synapse_Homo sapiens_hsa047240.52497361
115Folate biosynthesis_Homo sapiens_hsa007900.50995065
116AMPK signaling pathway_Homo sapiens_hsa041520.50429253
117VEGF signaling pathway_Homo sapiens_hsa043700.49054213
118Calcium signaling pathway_Homo sapiens_hsa040200.47822677
119Endocytosis_Homo sapiens_hsa041440.46954061
120Basal cell carcinoma_Homo sapiens_hsa052170.45201844
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44300912
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.43464139
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43230881
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42917692
125One carbon pool by folate_Homo sapiens_hsa006700.42870638
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.42388372
127DNA replication_Homo sapiens_hsa030300.41172882
128Renin-angiotensin system_Homo sapiens_hsa046140.41024770
129Pancreatic secretion_Homo sapiens_hsa049720.40730441
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39499890
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37722919
132Alcoholism_Homo sapiens_hsa050340.37632051
133p53 signaling pathway_Homo sapiens_hsa041150.36963992
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36026204
135Cholinergic synapse_Homo sapiens_hsa047250.35778777
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35115170
137Salivary secretion_Homo sapiens_hsa049700.34147375
138Synaptic vesicle cycle_Homo sapiens_hsa047210.33400976
139Protein digestion and absorption_Homo sapiens_hsa049740.33311756
140Metabolic pathways_Homo sapiens_hsa011000.32493216
141Inositol phosphate metabolism_Homo sapiens_hsa005620.30237714
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29526509
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29102999
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27541083
145Gastric acid secretion_Homo sapiens_hsa049710.27055447
146Pyrimidine metabolism_Homo sapiens_hsa002400.26967315
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26847411
148N-Glycan biosynthesis_Homo sapiens_hsa005100.24747642
149cAMP signaling pathway_Homo sapiens_hsa040240.23439611
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23282583
151Taste transduction_Homo sapiens_hsa047420.21176371
152Circadian entrainment_Homo sapiens_hsa047130.20664863
153B cell receptor signaling pathway_Homo sapiens_hsa046620.20606267
154Cocaine addiction_Homo sapiens_hsa050300.18646689
155Wnt signaling pathway_Homo sapiens_hsa043100.16560243
156Viral carcinogenesis_Homo sapiens_hsa052030.14632916
157Salmonella infection_Homo sapiens_hsa051320.12291135
158HIF-1 signaling pathway_Homo sapiens_hsa040660.11961962
159Sulfur metabolism_Homo sapiens_hsa009200.11636825
160RNA degradation_Homo sapiens_hsa030180.11337683

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