LYPD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)8.27345056
2keratinocyte differentiation (GO:0030216)8.10077553
3detection of bacterium (GO:0016045)7.62869313
4peptide cross-linking (GO:0018149)7.52539052
5long-chain fatty acid biosynthetic process (GO:0042759)7.00807893
6detection of other organism (GO:0098543)6.81866216
7epidermal cell differentiation (GO:0009913)6.63066679
8positive regulation of glomerulus development (GO:0090193)6.34524280
9regulation of transforming growth factor beta1 production (GO:0032908)6.31796939
10regulation of cell proliferation involved in kidney development (GO:1901722)6.05633104
11intermediate filament organization (GO:0045109)6.05548408
12epidermis development (GO:0008544)5.74456917
13skin morphogenesis (GO:0043589)5.68346935
14fatty acid elongation (GO:0030497)5.36654805
15regulation of ruffle assembly (GO:1900027)5.33616520
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.30113458
17G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.16754844
18behavioral response to nicotine (GO:0035095)5.09651720
19surfactant homeostasis (GO:0043129)5.03923094
20chemical homeostasis within a tissue (GO:0048875)4.93269961
21hemidesmosome assembly (GO:0031581)4.91066247
22lipoxygenase pathway (GO:0019372)4.87454478
23sphingoid metabolic process (GO:0046519)4.79260232
24keratinocyte proliferation (GO:0043616)4.71621086
25linoleic acid metabolic process (GO:0043651)4.35237447
26L-fucose catabolic process (GO:0042355)4.31986025
27fucose catabolic process (GO:0019317)4.31986025
28L-fucose metabolic process (GO:0042354)4.31986025
29regulation of glomerulus development (GO:0090192)4.30638668
30positive regulation of interleukin-8 secretion (GO:2000484)4.29076708
31regulation of natural killer cell differentiation (GO:0032823)4.26841119
32ectoderm development (GO:0007398)4.20786555
33positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.10998549
34sphingosine metabolic process (GO:0006670)4.08012682
35phospholipid efflux (GO:0033700)4.04835319
36glucosamine-containing compound catabolic process (GO:1901072)3.99521460
37intermediate filament cytoskeleton organization (GO:0045104)3.99464611
38phospholipid scrambling (GO:0017121)3.97688767
39intermediate filament-based process (GO:0045103)3.96568566
40keratinocyte development (GO:0003334)3.89958156
41positive regulation of cholesterol efflux (GO:0010875)3.86961823
42DNA deamination (GO:0045006)3.82214668
43virion attachment to host cell (GO:0019062)3.78102681
44adhesion of symbiont to host cell (GO:0044650)3.78102681
45parturition (GO:0007567)3.73732673
46diol metabolic process (GO:0034311)3.69093861
47positive regulation of transforming growth factor beta production (GO:0071636)3.59657137
48positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.58136920
49detection of external biotic stimulus (GO:0098581)3.49014545
50indolalkylamine metabolic process (GO:0006586)3.48712832
51regulation of interleukin-8 secretion (GO:2000482)3.42425873
52gamma-aminobutyric acid transport (GO:0015812)3.41882043
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.37201054
54cellular ketone body metabolic process (GO:0046950)3.32533729
55positive regulation of cholesterol transport (GO:0032376)3.31320322
56positive regulation of sterol transport (GO:0032373)3.31320322
57detection of light stimulus involved in visual perception (GO:0050908)3.30285270
58detection of light stimulus involved in sensory perception (GO:0050962)3.30285270
59platelet dense granule organization (GO:0060155)3.27110220
60indole-containing compound catabolic process (GO:0042436)3.25711292
61indolalkylamine catabolic process (GO:0046218)3.25711292
62tryptophan catabolic process (GO:0006569)3.25711292
63phosphatidylinositol acyl-chain remodeling (GO:0036149)3.25609874
64piRNA metabolic process (GO:0034587)3.22279373
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11968409
66kidney morphogenesis (GO:0060993)3.09591369
67negative regulation of telomere maintenance (GO:0032205)3.09105472
68axoneme assembly (GO:0035082)3.06756260
69negative regulation of interferon-gamma production (GO:0032689)3.03977355
70cyclooxygenase pathway (GO:0019371)3.03587980
71kynurenine metabolic process (GO:0070189)3.03287163
72ketone body metabolic process (GO:1902224)3.03056825
73G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.02328169
74eyelid development in camera-type eye (GO:0061029)3.02198646
75response to pheromone (GO:0019236)3.00323763
76negative regulation of stress fiber assembly (GO:0051497)2.99078850
77atrial cardiac muscle cell action potential (GO:0086014)2.99054070
78regulation of hypersensitivity (GO:0002883)2.91693970
79glycine transport (GO:0015816)2.91386539
80regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.90598974
81detection of biotic stimulus (GO:0009595)2.90000089
82purinergic nucleotide receptor signaling pathway (GO:0035590)2.89996672
83adhesion of symbiont to host (GO:0044406)2.89656866
84cornea development in camera-type eye (GO:0061303)2.89537243
85positive regulation of monocyte chemotaxis (GO:0090026)2.87470905
86long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.86339102
87protein polyglutamylation (GO:0018095)2.86293562
88establishment of planar polarity (GO:0001736)2.86243006
89establishment of tissue polarity (GO:0007164)2.86243006
90tryptophan metabolic process (GO:0006568)2.83600217
91phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.83573080
92sulfation (GO:0051923)2.83103921
93regulation of phospholipase A2 activity (GO:0032429)2.82376286
94indole-containing compound metabolic process (GO:0042430)2.82086385
95primary amino compound metabolic process (GO:1901160)2.81190883
96negative regulation of keratinocyte proliferation (GO:0010839)2.81066734
97reflex (GO:0060004)2.80261691
98water-soluble vitamin biosynthetic process (GO:0042364)2.80179788
99positive regulation of meiotic cell cycle (GO:0051446)2.80020846
100serotonin metabolic process (GO:0042428)2.79564562
101mannosylation (GO:0097502)2.79209478
102hormone catabolic process (GO:0042447)2.77864648
103respiratory chain complex IV assembly (GO:0008535)2.74821503
104preassembly of GPI anchor in ER membrane (GO:0016254)2.74403332
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74286339
106adaptation of signaling pathway (GO:0023058)2.73995404
107photoreceptor cell maintenance (GO:0045494)2.72491379
108regulation of protein localization to cell surface (GO:2000008)2.72441737
109epithelium development (GO:0060429)2.70786058
110regulation of neuron projection regeneration (GO:0070570)2.69628305
111regulation of axon regeneration (GO:0048679)2.69628305
112phosphatidylserine acyl-chain remodeling (GO:0036150)2.69535087
113atrioventricular valve morphogenesis (GO:0003181)2.67071930
114retinal cone cell development (GO:0046549)2.65955330
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65781061
116positive regulation of hair cycle (GO:0042635)2.63849054
117positive regulation of hair follicle development (GO:0051798)2.63849054
118positive regulation of fatty acid transport (GO:2000193)2.63563694
119regulation of mesoderm development (GO:2000380)2.61699335
120magnesium ion transport (GO:0015693)2.60038595
121regulation of cholesterol efflux (GO:0010874)2.60015858
122neuronal action potential (GO:0019228)2.59301514
123phosphatidylcholine acyl-chain remodeling (GO:0036151)2.58932184
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58747806
125nonmotile primary cilium assembly (GO:0035058)2.58483399
126sphingolipid biosynthetic process (GO:0030148)2.55323439
127regulation of action potential (GO:0098900)2.54283129
128protein complex biogenesis (GO:0070271)2.53042893
129skin development (GO:0043588)2.52577708
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51707828
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.51707828
132NADH dehydrogenase complex assembly (GO:0010257)2.51707828
133photoreceptor cell development (GO:0042461)2.49673324
134positive regulation of meiosis (GO:0045836)2.49244867
135epithelial cilium movement (GO:0003351)2.48043451
136regulation of neurotransmitter uptake (GO:0051580)2.47875101
137phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.47226652
138cilium morphogenesis (GO:0060271)2.46085998
139pseudouridine synthesis (GO:0001522)2.45618193
140regulation of transforming growth factor beta production (GO:0071634)2.45498281
141lymph vessel development (GO:0001945)2.45495602
142multicellular organism reproduction (GO:0032504)2.44919766
143neural tube formation (GO:0001841)2.44556821
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44511063
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.43640108
146positive regulation of collagen biosynthetic process (GO:0032967)2.43115871
147proline transport (GO:0015824)2.42937461
148ceramide biosynthetic process (GO:0046513)2.42845573
149protein K11-linked deubiquitination (GO:0035871)2.42098923
150negative regulation of T cell mediated immunity (GO:0002710)2.41949370
151amino acid salvage (GO:0043102)2.41528867
152L-methionine salvage (GO:0071267)2.41528867
153L-methionine biosynthetic process (GO:0071265)2.41528867
154negative regulation of mast cell activation (GO:0033004)2.41500310
155regulation of somitogenesis (GO:0014807)2.41080452
156synaptic transmission, cholinergic (GO:0007271)2.41040739
157negative regulation of cell fate specification (GO:0009996)2.40588586
158DNA methylation involved in gamete generation (GO:0043046)2.39650572
159regulation of meiosis I (GO:0060631)2.39262943
160negative regulation of reactive oxygen species metabolic process (GO:2000378)2.39006063
161ubiquinone biosynthetic process (GO:0006744)2.38847315
162positive regulation of mitochondrial membrane permeability (GO:0035794)2.38691701
163cytidine deamination (GO:0009972)2.38615192
164cytidine metabolic process (GO:0046087)2.38615192
165cytidine catabolic process (GO:0006216)2.38615192
166polyol catabolic process (GO:0046174)2.38458562
167regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37435410
168L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.36523965
169positive regulation of Cdc42 GTPase activity (GO:0043089)2.35681943
170action potential (GO:0001508)2.35463245
171behavioral response to ethanol (GO:0048149)2.35401401
172cytochrome complex assembly (GO:0017004)2.35132787
173rhodopsin mediated signaling pathway (GO:0016056)2.35122952
174hair cell differentiation (GO:0035315)2.34274336
175purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.33467765
1763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.33467765
177negative regulation of actin filament bundle assembly (GO:0032232)2.32974379
178positive regulation of collagen metabolic process (GO:0010714)2.32882713
179planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31370099
180regulation of monocyte chemotaxis (GO:0090025)2.31153875
181regulation of hair cycle (GO:0042634)2.25145184
182establishment of skin barrier (GO:0061436)17.9617427
183keratinization (GO:0031424)15.5848960
184regulation of water loss via skin (GO:0033561)15.4751603
185desmosome organization (GO:0002934)11.9910650
186molting cycle (GO:0042303)11.0785630
187hair cycle (GO:0042633)11.0785630
188multicellular organismal water homeostasis (GO:0050891)10.0620755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.06963893
2ZNF274_21170338_ChIP-Seq_K562_Hela3.64539080
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.14871592
4GBX2_23144817_ChIP-Seq_PC3_Human2.70567540
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67161697
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.57921616
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.44003004
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31942229
9EZH2_22144423_ChIP-Seq_EOC_Human2.31090017
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.25069649
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20688612
12IGF1R_20145208_ChIP-Seq_DFB_Human2.19838159
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19758889
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18225997
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12675707
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07137237
17TP63_17297297_ChIP-ChIP_HaCaT_Human11.5796305
18P300_19829295_ChIP-Seq_ESCs_Human1.93718846
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.91108484
20FUS_26573619_Chip-Seq_HEK293_Human1.86432608
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.85527996
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84996680
23TP53_18474530_ChIP-ChIP_U2OS_Human1.83438037
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.83190555
25TAF15_26573619_Chip-Seq_HEK293_Human1.80015814
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78894901
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78894901
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.78705021
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74472387
30ER_23166858_ChIP-Seq_MCF-7_Human1.74398772
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72160030
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.71626728
33GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.69825744
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67232679
35TP63_23658742_ChIP-Seq_EP156T_Human1.65901960
36VDR_22108803_ChIP-Seq_LS180_Human1.65604905
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63134725
38EWS_26573619_Chip-Seq_HEK293_Human1.62807951
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58689552
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58642115
41AR_25329375_ChIP-Seq_VCAP_Human1.57069769
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55355561
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55355561
44* REST_21632747_ChIP-Seq_MESCs_Mouse1.52862366
45SMAD4_21799915_ChIP-Seq_A2780_Human1.51112568
46GATA6_21074721_ChIP-Seq_CACO-2_Human1.49592538
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47409238
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46571334
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.46571334
50CBP_20019798_ChIP-Seq_JUKART_Human1.46194658
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46194658
52STAT3_23295773_ChIP-Seq_U87_Human1.46077499
53TCF4_23295773_ChIP-Seq_U87_Human1.43280921
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42946979
55SOX2_20726797_ChIP-Seq_SW620_Human1.42716084
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41452038
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.41373944
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41295031
59AR_21572438_ChIP-Seq_LNCaP_Human1.39900028
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38499768
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38061946
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.36904657
63* GATA3_21878914_ChIP-Seq_MCF-7_Human1.35468300
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34146167
65NANOG_19829295_ChIP-Seq_ESCs_Human1.33736993
66SOX2_19829295_ChIP-Seq_ESCs_Human1.33736993
67RXR_22108803_ChIP-Seq_LS180_Human1.31823642
68CJUN_26792858_Chip-Seq_BT549_Human1.30840686
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.30423908
70* TP53_22573176_ChIP-Seq_HFKS_Human1.29802174
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28949254
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27900374
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27746841
74NCOR_22424771_ChIP-Seq_293T_Human1.27042574
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24679827
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24166681
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23984918
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.23302338
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22085325
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.21904312
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.21725721
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.21423467
83AR_20517297_ChIP-Seq_VCAP_Human1.21370696
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20510281
85RNF2_27304074_Chip-Seq_NSC_Mouse1.19068763
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18984725
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18220243
88HOXB7_26014856_ChIP-Seq_BT474_Human1.17207296
89RUNX2_22187159_ChIP-Seq_PCA_Human1.17191570
90KLF5_25053715_ChIP-Seq_YYC3_Human1.16641021
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16357278
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15922181
93BCAT_22108803_ChIP-Seq_LS180_Human1.15725582
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15645143
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.15259730
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14912621
97RBPJ_21746931_ChIP-Seq_IB4_Human1.13666949
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13421733
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11976233
100CDX2_22108803_ChIP-Seq_LS180_Human1.11685928
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11400164
102CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11088324
103MYC_19829295_ChIP-Seq_ESCs_Human1.11007939
104TP63_22573176_ChIP-Seq_HFKS_Human1.10813614
105* CEBPB_22108803_ChIP-Seq_LS180_Human1.10735138
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10687959
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.10365384
108GATA4_25053715_ChIP-Seq_YYC3_Human1.09244666
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.08499221
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07896583
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.07893933
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07003563
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.06855192
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06180632
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05473614
116FOXH1_21741376_ChIP-Seq_EPCs_Human1.05338181
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04386622
118MYC_18940864_ChIP-ChIP_HL60_Human1.04356521
119HNFA_21074721_ChIP-Seq_CACO-2_Human1.04062676
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.04051352
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03353267
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02314602
123ERA_21632823_ChIP-Seq_H3396_Human1.02284088
124GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01453975
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00730763
126RNF2_27304074_Chip-Seq_ESCs_Mouse1.00647126
127P53_22387025_ChIP-Seq_ESCs_Mouse1.00240189
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00067908
129ZNF263_19887448_ChIP-Seq_K562_Human0.98931749
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.97733830
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97575732
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95133126
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95089252
134TCF4_22108803_ChIP-Seq_LS180_Human0.93641200
135AHR_22903824_ChIP-Seq_MCF-7_Human0.93201241
136CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93085594
137UBF1/2_26484160_Chip-Seq_HMECs_Human0.92970813
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92361396
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.91042354
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90845403
141RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90705309
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90705309
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90319498
144CTCF_27219007_Chip-Seq_Bcells_Human0.89954267
145TP53_20018659_ChIP-ChIP_R1E_Mouse0.89695941
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89218909
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88527649
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87755388
149TP53_16413492_ChIP-PET_HCT116_Human0.86073778
150PHF8_20622853_ChIP-Seq_HELA_Human0.85488839
151HTT_18923047_ChIP-ChIP_STHdh_Human0.85337011
152JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83505574
153RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82323900
154Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81400800
155ETV1_20927104_ChIP-Seq_GIST48_Human0.80042486
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79879902
157* ARNT_22903824_ChIP-Seq_MCF-7_Human0.79582594
158PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79307678
159CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78931099
160DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78895489
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78464486
162STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78361125
163CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78196439
164VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77782379
165PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.77734533
166EGR1_19032775_ChIP-ChIP_M12_Human0.76699183
167CTCF_20526341_ChIP-Seq_ESCs_Human0.76309640
168FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.75820284
169TBL1_22424771_ChIP-Seq_293T_Human0.75479977
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75458321
171P53_21459846_ChIP-Seq_SAOS-2_Human0.74710201
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.73361210
173* TAF2_19829295_ChIP-Seq_ESCs_Human0.73257112
174AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72240863
175EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69890045
176MTF2_20144788_ChIP-Seq_MESCs_Mouse0.69634883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.01216453
2MP0005275_abnormal_skin_tensile6.41858454
3MP0010234_abnormal_vibrissa_follicle6.25012449
4MP0005501_abnormal_skin_physiology5.40812415
5MP0005451_abnormal_body_composition5.40788104
6MP0003941_abnormal_skin_development5.33414812
7MP0000579_abnormal_nail_morphology3.85076454
8MP0004381_abnormal_hair_follicle3.83447837
9MP0002060_abnormal_skin_morphology3.26941390
10MP0001216_abnormal_epidermal_layer3.26287343
11MP0004947_skin_inflammation3.21594869
12MP0010771_integument_phenotype3.13078092
13MP0010678_abnormal_skin_adnexa3.05513379
14MP0002098_abnormal_vibrissa_morphology2.98658563
15MP0000647_abnormal_sebaceous_gland2.94695882
16MP0004885_abnormal_endolymph2.85863096
17MP0000569_abnormal_digit_pigmentation2.70413994
18MP0003191_abnormal_cellular_cholesterol2.50715642
19MP0000383_abnormal_hair_follicle2.49132206
20MP0001968_abnormal_touch/_nociception2.47438887
21MP0004043_abnormal_pH_regulation2.45902895
22MP0005646_abnormal_pituitary_gland2.43605015
23MP0005551_abnormal_eye_electrophysiolog2.42929831
24MP0000377_abnormal_hair_follicle2.35114294
25MP0003195_calcinosis2.33967155
26MP0009046_muscle_twitch2.30662539
27MP0001501_abnormal_sleep_pattern2.17992244
28MP0002102_abnormal_ear_morphology2.13260478
29MP0000427_abnormal_hair_cycle2.12278477
30MP0009745_abnormal_behavioral_response2.11919207
31MP0003646_muscle_fatigue2.10964187
32MP0003880_abnormal_central_pattern2.08681580
33MP0003453_abnormal_keratinocyte_physiol2.05452673
34MP0002837_dystrophic_cardiac_calcinosis1.99100491
35MP0002254_reproductive_system_inflammat1.96745696
36MP0004142_abnormal_muscle_tone1.96469981
37MP0008872_abnormal_physiological_respon1.95108869
38MP0002736_abnormal_nociception_after1.86613665
39MP0004147_increased_porphyrin_level1.85854196
40MP0005174_abnormal_tail_pigmentation1.85336336
41MP0001486_abnormal_startle_reflex1.84772263
42MP0005645_abnormal_hypothalamus_physiol1.81182595
43MP0008877_abnormal_DNA_methylation1.80908421
44MP0000467_abnormal_esophagus_morphology1.78481315
45MP0006072_abnormal_retinal_apoptosis1.78004615
46MP0002272_abnormal_nervous_system1.72463048
47MP0009931_abnormal_skin_appearance1.70997733
48MP0001191_abnormal_skin_condition1.62526057
49MP0003878_abnormal_ear_physiology1.60905665
50MP0005377_hearing/vestibular/ear_phenot1.60905665
51MP0005253_abnormal_eye_physiology1.56992741
52MP0002064_seizures1.56890742
53MP0000762_abnormal_tongue_morphology1.56560744
54MP0004782_abnormal_surfactant_physiolog1.54170802
55MP0001485_abnormal_pinna_reflex1.51846967
56MP0001986_abnormal_taste_sensitivity1.49852484
57MP0003787_abnormal_imprinting1.48717538
58MP0002733_abnormal_thermal_nociception1.48623495
59MP0008875_abnormal_xenobiotic_pharmacok1.47844746
60MP0002735_abnormal_chemical_nociception1.46925059
61MP0001970_abnormal_pain_threshold1.46262025
62MP0002876_abnormal_thyroid_physiology1.43508230
63MP0002009_preneoplasia1.40188058
64MP0002572_abnormal_emotion/affect_behav1.39821742
65MP0005167_abnormal_blood-brain_barrier1.37496989
66MP0000367_abnormal_coat/_hair1.34925479
67MP0001905_abnormal_dopamine_level1.32900911
68MP0004185_abnormal_adipocyte_glucose1.32493918
69MP0002638_abnormal_pupillary_reflex1.31408292
70MP0002653_abnormal_ependyma_morphology1.29160343
71MP0006292_abnormal_olfactory_placode1.29144695
72MP0004924_abnormal_behavior1.28983231
73MP0005386_behavior/neurological_phenoty1.28983231
74MP0003705_abnormal_hypodermis_morpholog1.27548681
75MP0001243_abnormal_dermal_layer1.27488839
76MP0003635_abnormal_synaptic_transmissio1.23233444
77MP0000631_abnormal_neuroendocrine_gland1.19727723
78MP0006276_abnormal_autonomic_nervous1.18787818
79MP0002067_abnormal_sensory_capabilities1.18169832
80MP0002909_abnormal_adrenal_gland1.16726389
81MP0002138_abnormal_hepatobiliary_system1.16419510
82MP0002557_abnormal_social/conspecific_i1.16180744
83MP0002938_white_spotting1.10766235
84MP0001188_hyperpigmentation1.10663217
85MP0002734_abnormal_mechanical_nocicepti1.09999629
86MP0004133_heterotaxia1.09431040
87MP0001346_abnormal_lacrimal_gland1.07147488
88MP0002063_abnormal_learning/memory/cond1.06977586
89MP0001502_abnormal_circadian_rhythm1.05147151
90MP0003566_abnormal_cell_adhesion1.04168198
91MP0002163_abnormal_gland_morphology1.04073632
92MP0005389_reproductive_system_phenotype1.01112229
93MP0003283_abnormal_digestive_organ0.97324017
94MP0000465_gastrointestinal_hemorrhage0.97026734
95MP0003136_yellow_coat_color0.95027671
96MP0000566_synostosis0.93624405
97MP0000230_abnormal_systemic_arterial0.92561158
98MP0005379_endocrine/exocrine_gland_phen0.92322646
99MP0003950_abnormal_plasma_membrane0.90482145
100MP0005409_darkened_coat_color0.90453070
101MP0002229_neurodegeneration0.88572740
102MP0004145_abnormal_muscle_electrophysio0.87313835
103MP0001919_abnormal_reproductive_system0.85727327
104MP0001440_abnormal_grooming_behavior0.85481808
105MP0003137_abnormal_impulse_conducting0.85093528
106MP0005423_abnormal_somatic_nervous0.83877284
107MP0004215_abnormal_myocardial_fiber0.83802455
108MP0002160_abnormal_reproductive_system0.83163299
109MP0000015_abnormal_ear_pigmentation0.78961772
110MP0001851_eye_inflammation0.78881165
111MP0001529_abnormal_vocalization0.77064881
112MP0008775_abnormal_heart_ventricle0.75599418
113MP0003633_abnormal_nervous_system0.74553650
114MP0008995_early_reproductive_senescence0.72899065
115MP0005195_abnormal_posterior_eye0.72585835
116MP0005448_abnormal_energy_balance0.72519709
117MP0001756_abnormal_urination0.72311398
118MP0002234_abnormal_pharynx_morphology0.72158375
119MP0001340_abnormal_eyelid_morphology0.70564645
120MP0002095_abnormal_skin_pigmentation0.70205583
121MP0001784_abnormal_fluid_regulation0.67764994
122MP0009379_abnormal_foot_pigmentation0.60868255
123MP0002177_abnormal_outer_ear0.55307585
124MP0005075_abnormal_melanosome_morpholog0.54268294
125MP0002249_abnormal_larynx_morphology0.47312768
126MP0000516_abnormal_urinary_system0.42444493
127MP0005367_renal/urinary_system_phenotyp0.42444493
128MP0001177_atelectasis0.42086827
129MP0002148_abnormal_hypersensitivity_rea0.42063292
130MP0005666_abnormal_adipose_tissue0.40928847
131MP0002166_altered_tumor_susceptibility0.40374152
132MP0002006_tumorigenesis0.38041662
133MP0002277_abnormal_respiratory_mucosa0.36405829
134MP0008004_abnormal_stomach_pH0.34594712
135MP0000627_abnormal_mammary_gland0.32746968
136MP0002090_abnormal_vision0.31996053
137MP0009053_abnormal_anal_canal0.29234718
138MP0003315_abnormal_perineum_morphology0.29211659
139MP0000470_abnormal_stomach_morphology0.28922284
140MP0003436_decreased_susceptibility_to0.27302669
141MP0008961_abnormal_basal_metabolism0.27023220
142MP0003755_abnormal_palate_morphology0.26456871
143MP0005375_adipose_tissue_phenotype0.26405553
144MP0003329_amyloid_beta_deposits0.24773605
145MP0001542_abnormal_bone_strength0.24101424
146MP0003011_delayed_dark_adaptation0.23460502
147MP0004742_abnormal_vestibular_system0.21948276
148MP0005076_abnormal_cell_differentiation0.20314407
149MP0001873_stomach_inflammation0.19174539
150MP0000432_abnormal_head_morphology0.19150032
151MP0006054_spinal_hemorrhage0.18863496
152MP0010030_abnormal_orbit_morphology0.18573051
153MP0009333_abnormal_splenocyte_physiolog0.18496287
154MP0000372_irregular_coat_pigmentation0.18061493
155MP0005023_abnormal_wound_healing0.17709202
156MP0004019_abnormal_vitamin_homeostasis0.17571569
157MP0002282_abnormal_trachea_morphology0.17240268
158MP0003724_increased_susceptibility_to0.17005298
159MP0002111_abnormal_tail_morphology0.16859660
160MP0002877_abnormal_melanocyte_morpholog0.16839729
161MP0001984_abnormal_olfaction0.16231919
162MP0003763_abnormal_thymus_physiology0.15442222
163MP0005508_abnormal_skeleton_morphology0.15429360
164MP0009764_decreased_sensitivity_to0.15371666
165MP0009384_cardiac_valve_regurgitation0.14672281
166MP0002697_abnormal_eye_size0.14263199
167MP0003385_abnormal_body_wall0.13709322
168MP0004264_abnormal_extraembryonic_tissu0.13373068
169MP0005623_abnormal_meninges_morphology0.12771210
170MP0000538_abnormal_urinary_bladder0.12302995
171MP0002233_abnormal_nose_morphology0.11431344
172MP0005388_respiratory_system_phenotype0.11201082
173MP0002133_abnormal_respiratory_system0.11201082
174MP0005000_abnormal_immune_tolerance0.11178890
175MP0010386_abnormal_urinary_bladder0.10983706
176MP0005390_skeleton_phenotype0.10979198
177MP0005025_abnormal_response_to0.10791236

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)9.41411198
2Abnormality of nail color (HP:0100643)8.96254770
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.91149902
4Hypotrichosis (HP:0001006)7.99028053
5Erythroderma (HP:0001019)6.50741994
6Woolly hair (HP:0002224)6.21429824
7Palmoplantar hyperkeratosis (HP:0000972)5.99598639
8Onycholysis (HP:0001806)5.71881066
9Palmar hyperkeratosis (HP:0010765)5.67816316
10Plantar hyperkeratosis (HP:0007556)5.65539674
11Erythema (HP:0010783)5.62336790
12Gangrene (HP:0100758)5.61052741
13Right ventricular cardiomyopathy (HP:0011663)5.54675928
14Parakeratosis (HP:0001036)5.16660679
15Ectropion (HP:0000656)5.09383800
16Corneal erosion (HP:0200020)4.73313631
17Thick nail (HP:0001805)4.58605022
18Pili torti (HP:0003777)4.44510433
19Lip pit (HP:0100267)4.44501091
20Eczematoid dermatitis (HP:0000976)4.30647880
21Fragile nails (HP:0001808)4.30302451
22Hypohidrosis (HP:0000966)4.16442371
23Pruritus (HP:0000989)4.06453242
24Pancreatic cysts (HP:0001737)3.98476303
25Conjunctival hamartoma (HP:0100780)3.84406631
26Brittle hair (HP:0002299)3.82321456
27Curly hair (HP:0002212)3.77163907
28Type II lissencephaly (HP:0007260)3.76470152
29Molar tooth sign on MRI (HP:0002419)3.73964828
30Abnormality of midbrain morphology (HP:0002418)3.73964828
31Nail dystrophy (HP:0008404)3.71949013
32Congenital stationary night blindness (HP:0007642)3.68870324
33Palmoplantar keratoderma (HP:0000982)3.58395895
34Pancreatic fibrosis (HP:0100732)3.54304519
35Hyporeflexia of lower limbs (HP:0002600)3.51405769
36True hermaphroditism (HP:0010459)3.48343326
37Abnormal blistering of the skin (HP:0008066)3.40846943
38Hyperventilation (HP:0002883)3.39719039
39Natal tooth (HP:0000695)3.29852597
40Hypergammaglobulinemia (HP:0010702)3.29819801
41Nephronophthisis (HP:0000090)3.25398578
42Lack of skin elasticity (HP:0100679)3.19589107
43Furrowed tongue (HP:0000221)3.17755023
44Abnormality of the renal cortex (HP:0011035)3.16597217
45Distal lower limb muscle weakness (HP:0009053)3.15109214
46Sparse eyelashes (HP:0000653)2.99699926
47Milia (HP:0001056)2.99033751
48Advanced eruption of teeth (HP:0006288)2.91906517
49Abnormality of the renal medulla (HP:0100957)2.91004803
50Sparse scalp hair (HP:0002209)2.88556911
51Ventricular tachycardia (HP:0004756)2.87428651
52Acanthosis nigricans (HP:0000956)2.84372491
53Alopecia of scalp (HP:0002293)2.84367248
54Abnormal hair laboratory examination (HP:0003328)2.75932267
55Attenuation of retinal blood vessels (HP:0007843)2.71611032
56Dehydration (HP:0001944)2.60028910
57Medial flaring of the eyebrow (HP:0010747)2.59768661
58Areflexia of lower limbs (HP:0002522)2.59277346
59Lissencephaly (HP:0001339)2.54303421
60Malignant hyperthermia (HP:0002047)2.53108277
61Polydipsia (HP:0001959)2.50620238
62Abnormal drinking behavior (HP:0030082)2.50620238
63Chronic hepatic failure (HP:0100626)2.50489204
64Dry skin (HP:0000958)2.47808552
65Pendular nystagmus (HP:0012043)2.46297201
66Follicular hyperkeratosis (HP:0007502)2.45102345
67Abolished electroretinogram (ERG) (HP:0000550)2.43645834
68Tubular atrophy (HP:0000092)2.43385633
69Gaze-evoked nystagmus (HP:0000640)2.40548052
70Hypothermia (HP:0002045)2.40498350
71Birth length less than 3rd percentile (HP:0003561)2.38551913
72Renal cortical cysts (HP:0000803)2.37897367
73Concave nail (HP:0001598)2.37309564
74Inability to walk (HP:0002540)2.34411045
75Cerebellar dysplasia (HP:0007033)2.33750175
76Decreased central vision (HP:0007663)2.32440466
77Corneal dystrophy (HP:0001131)2.31158339
78Large for gestational age (HP:0001520)2.29331423
79Cystic liver disease (HP:0006706)2.28355654
80Sepsis (HP:0100806)2.26918976
81Decreased circulating renin level (HP:0003351)2.25583717
82Premature ovarian failure (HP:0008209)2.25179987
83Oral leukoplakia (HP:0002745)2.25166816
84Abnormal rod and cone electroretinograms (HP:0008323)2.23205314
85Keratoconus (HP:0000563)2.19632481
86Increased corneal curvature (HP:0100692)2.19632481
87Ridged nail (HP:0001807)2.16822082
88Progressive cerebellar ataxia (HP:0002073)2.15238181
89Slow-growing hair (HP:0002217)2.12007382
90Abnormality of hair growth rate (HP:0011363)2.12007382
91Hemiparesis (HP:0001269)2.10656985
92Febrile seizures (HP:0002373)2.08982674
93Focal motor seizures (HP:0011153)2.07742979
94Hamartoma of the eye (HP:0010568)2.07179758
95Broad-based gait (HP:0002136)2.06341010
96Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05365769
97Congenital, generalized hypertrichosis (HP:0004540)2.05141285
98Abnormality of alanine metabolism (HP:0010916)2.04475533
99Hyperalaninemia (HP:0003348)2.04475533
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04475533
101Gait imbalance (HP:0002141)2.03673674
102Protruding tongue (HP:0010808)2.03595258
103Abnormality of small intestinal villus morphology (HP:0011472)2.02892259
104Villous atrophy (HP:0011473)2.02892259
105Polyuria (HP:0000103)2.02181066
106Fair hair (HP:0002286)2.02025330
107Retinal dysplasia (HP:0007973)2.01914376
108Asthma (HP:0002099)2.00075162
109Increased IgE level (HP:0003212)10.3715685
110Widely spaced teeth (HP:0000687)1.95793294
111Abnormality of the renal collecting system (HP:0004742)1.95732131
112Duplicated collecting system (HP:0000081)1.95224050
113Stomach cancer (HP:0012126)1.94952634
114Congenital primary aphakia (HP:0007707)1.94355428
115Acute necrotizing encephalopathy (HP:0006965)1.94353325
116Hyperhidrosis (HP:0000975)1.93988258
117Sclerocornea (HP:0000647)1.93753449
118Progressive inability to walk (HP:0002505)1.93265678
119Patellar aplasia (HP:0006443)1.92697792
120Urticaria (HP:0001025)1.92089529
121Paralysis (HP:0003470)1.92008674
122Dry hair (HP:0011359)1.90241137
123Aplasia/hypoplasia of the uterus (HP:0008684)1.89722708
124Mitochondrial inheritance (HP:0001427)1.89138596
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.89022186
126Absent/shortened dynein arms (HP:0200106)1.89022186
127Aplasia/Hypoplasia of the patella (HP:0006498)1.87106238
1283-Methylglutaconic aciduria (HP:0003535)1.85858101
129Genetic anticipation (HP:0003743)1.84657858
130Nephrogenic diabetes insipidus (HP:0009806)1.84374293
131Optic nerve hypoplasia (HP:0000609)1.84262904
132Congenital hepatic fibrosis (HP:0002612)1.83969228
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83378439
134Hypomagnesemia (HP:0002917)1.83101713
135Chorioretinal atrophy (HP:0000533)1.82819925
136Optic disc pallor (HP:0000543)1.82417764
137Increased CSF lactate (HP:0002490)1.81939797
138Abnormality of the salivary glands (HP:0010286)1.81213274
139Skin ulcer (HP:0200042)1.80340346
140Progressive macrocephaly (HP:0004481)1.80318897
141Male pseudohermaphroditism (HP:0000037)1.77929404
142Abnormality of the pons (HP:0007361)1.77771274
143Severe Myopia (HP:0011003)1.76100052
144Pachygyria (HP:0001302)1.75848649
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.75371090
146Anencephaly (HP:0002323)1.75006562
147Sensory axonal neuropathy (HP:0003390)1.73829765
148Aplasia cutis congenita (HP:0001057)1.73617970
149Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73059898
150Abnormality of the gastric mucosa (HP:0004295)1.68851957
151Ventricular fibrillation (HP:0001663)1.67637969
152Popliteal pterygium (HP:0009756)1.67364539
153Abnormality of secondary sexual hair (HP:0009888)1.63854164
154Abnormality of the axillary hair (HP:0100134)1.63854164
155Fatigable weakness (HP:0003473)1.63627817
156Abnormality of the neuromuscular junction (HP:0003398)1.63627817
157Blepharitis (HP:0000498)1.63624378
158Laryngomalacia (HP:0001601)1.62354903
159Everted lower lip vermilion (HP:0000232)1.58251139
160Pustule (HP:0200039)1.54902426
161Distal lower limb amyotrophy (HP:0008944)1.54304233
162Ulnar claw (HP:0001178)1.52250366
163Fine hair (HP:0002213)1.50091564
164Atrophic scars (HP:0001075)1.48357798
165Neck muscle weakness (HP:0000467)1.44291599
166Oligodontia (HP:0000677)1.43027124
167Anhidrosis (HP:0000970)1.42929670
168Amelogenesis imperfecta (HP:0000705)1.41011337
169Round ear (HP:0100830)1.40286528
170Anonychia (HP:0001798)1.39768866
171Steppage gait (HP:0003376)1.36048220
172Skin pits (HP:0100276)1.34588704
173Hypoplastic labia majora (HP:0000059)1.34587183
174Conical tooth (HP:0000698)1.32855644
175Increased connective tissue (HP:0009025)1.32715167
176Muscle fiber inclusion bodies (HP:0100299)1.32683404
177Nemaline bodies (HP:0003798)1.32302088
178Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.30415953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.46595023
2FRK5.41284219
3MAPKAPK35.22794714
4ADRBK23.23882707
5FER3.19456210
6ACVR1B3.07470834
7MST1R3.02608079
8BLK2.99955273
9LATS12.51813101
10MAP3K32.48960004
11WNK42.47373353
12TAOK32.41300194
13DAPK22.34343225
14IRAK32.19457065
15MAP4K22.18227256
16INSRR2.16823061
17ZAK2.11991187
18CASK2.11964585
19WNK32.06280810
20PINK12.05231604
21PIK3CG1.98332794
22MAP3K141.93837392
23GRK11.90795161
24FGFR11.86484661
25MAPK131.85162137
26TGFBR11.84635767
27RPS6KB21.84491161
28TLK11.83358741
29TRPM71.75324247
30EPHA31.70744279
31PIM21.69439426
32MAP3K21.69222824
33TXK1.61722814
34MAP3K41.55869812
35MAP3K91.55327503
36EPHB21.49340289
37BMPR21.48090788
38OXSR11.46774979
39MAPKAPK51.39435582
40ERBB31.38465818
41STK391.34966268
42RIPK41.29185349
43MAP3K71.27989183
44EPHB11.23384807
45MKNK21.19580832
46CAMKK21.19203983
47BCR1.18527646
48SRPK11.15512504
49MARK11.06781234
50MAP3K121.03829986
51PRKCG1.03145156
52OBSCN1.02894773
53MAP3K10.99702659
54BCKDK0.99435279
55PHKG20.97917161
56PHKG10.97917161
57PKN10.93768543
58EIF2AK20.93218040
59EPHA20.92193703
60STK240.90283061
61PTK2B0.88877117
62PNCK0.87935097
63TIE10.86537972
64TNIK0.86274855
65STK100.85970881
66YES10.85902135
67ITK0.85866469
68PAK30.84812864
69TTN0.84788976
70NEK20.83803185
71FGR0.83036858
72MAPK150.81790905
73PLK20.81130668
74MAPKAPK20.80684488
75NTRK30.80624303
76DYRK20.79966954
77FGFR20.78778729
78MAP3K110.77032345
79NME10.76664990
80EPHA40.76646875
81DYRK1B0.76448734
82IKBKE0.76167732
83MAP2K70.75936444
84LATS20.75301943
85STK38L0.74190451
86CDK60.73685647
87CSNK1G20.73228590
88PBK0.71968245
89CAMK10.70721349
90TEC0.70051658
91MAP2K60.69530117
92NEK90.68121729
93TAOK10.68029274
94CAMKK10.67012298
95ERN10.66947828
96IKBKB0.66835628
97BMPR1B0.66638155
98MAP2K30.66255359
99CAMK2A0.65030859
100PTK60.64940892
101PRKCQ0.63408385
102CSNK1G10.61133844
103DMPK0.58419533
104PRKD10.58299966
105CSNK1G30.57302270
106CSNK1D0.57214841
107VRK10.56127046
108MAP2K40.55818446
109MAP3K50.55701891
110STK30.54891878
111TRIM280.54826883
112SYK0.54770539
113IRAK40.54032732
114PRKCE0.52860602
115GRK70.50450978
116TBK10.49857563
117IRAK10.49598888
118MET0.49481580
119KIT0.49287189
120SIK20.49039904
121CSNK1A10.47393793
122PRKACA0.47031034
123MUSK0.46795639
124CHUK0.46597103
125PRKAA20.45921947
126MAPK120.45684642
127SGK2230.45526080
128SGK4940.45526080
129LRRK20.44466311
130NUAK10.43738536
131CSNK1A1L0.43432479
132NLK0.43171362
133CDK190.42052349
134PIK3CA0.42011193
135FGFR30.41772463
136CDK30.40722530
137ADRBK10.39994266
138PRKCH0.39208786
139PRKCA0.38556577
140MAP2K10.38205717
141TGFBR20.38189321
142GRK50.36960555
143MAP3K60.36802789
144WNK10.36572849
145ERBB40.36532178
146TYK20.36373997
147RPS6KA50.35501235
148IGF1R0.35491127
149RPS6KA10.35371767
150ABL10.35256190
151JAK10.35197291
152FGFR40.35118815
153NTRK20.34881713
154MAPK40.34562518
155MINK10.33740322
156STK110.33682516
157HCK0.32952354
158CAMK1D0.32727470
159MKNK10.32438830
160PRKG10.31893756
161ERBB20.31645007
162AURKA0.30328413
163MARK20.29227340
164ROCK10.28602096
165PRKCI0.28429793
166BMX0.27927881

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006003.86566320
2Fatty acid elongation_Homo sapiens_hsa000623.38873446
3Linoleic acid metabolism_Homo sapiens_hsa005913.25656223
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.10978539
5Arachidonic acid metabolism_Homo sapiens_hsa005902.79607587
6Ether lipid metabolism_Homo sapiens_hsa005652.43063120
7Nitrogen metabolism_Homo sapiens_hsa009102.40171560
8Nicotine addiction_Homo sapiens_hsa050332.32939275
9Phototransduction_Homo sapiens_hsa047442.32087635
10ABC transporters_Homo sapiens_hsa020102.14832059
11Oxidative phosphorylation_Homo sapiens_hsa001902.13646484
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.10499651
13Histidine metabolism_Homo sapiens_hsa003402.00690403
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.94446857
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91402608
16Butanoate metabolism_Homo sapiens_hsa006501.88983047
17Staphylococcus aureus infection_Homo sapiens_hsa051501.83040721
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.76334898
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69899610
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57133290
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56955342
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54651678
23Tight junction_Homo sapiens_hsa045301.51784621
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.50553394
25Caffeine metabolism_Homo sapiens_hsa002321.48771445
26Tryptophan metabolism_Homo sapiens_hsa003801.46588830
27Axon guidance_Homo sapiens_hsa043601.44108977
28Parkinsons disease_Homo sapiens_hsa050121.41692959
29Pertussis_Homo sapiens_hsa051331.41569351
30Morphine addiction_Homo sapiens_hsa050321.35889933
31Taste transduction_Homo sapiens_hsa047421.33682002
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.32128675
33Steroid biosynthesis_Homo sapiens_hsa001001.29134364
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29118269
35GnRH signaling pathway_Homo sapiens_hsa049121.25055737
36Sphingolipid signaling pathway_Homo sapiens_hsa040711.22713897
37Protein export_Homo sapiens_hsa030601.21881599
38Collecting duct acid secretion_Homo sapiens_hsa049661.19394125
39Circadian entrainment_Homo sapiens_hsa047131.19334000
40Glutamatergic synapse_Homo sapiens_hsa047241.18856069
41VEGF signaling pathway_Homo sapiens_hsa043701.13857479
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13476246
43Renin secretion_Homo sapiens_hsa049241.12461044
44GABAergic synapse_Homo sapiens_hsa047271.11296885
45Chemical carcinogenesis_Homo sapiens_hsa052041.11051174
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09647896
47Insulin secretion_Homo sapiens_hsa049111.09278332
48Serotonergic synapse_Homo sapiens_hsa047261.09119985
49Retinol metabolism_Homo sapiens_hsa008301.08596706
50RNA polymerase_Homo sapiens_hsa030201.07918075
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.07896922
52Fat digestion and absorption_Homo sapiens_hsa049751.07892115
53Propanoate metabolism_Homo sapiens_hsa006401.06998981
54Adherens junction_Homo sapiens_hsa045201.06384419
55Selenocompound metabolism_Homo sapiens_hsa004501.05529285
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.05197482
57Basal transcription factors_Homo sapiens_hsa030221.05193709
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05105124
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.04504344
60Alzheimers disease_Homo sapiens_hsa050101.03280896
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02998245
62Cardiac muscle contraction_Homo sapiens_hsa042601.02983465
63Rheumatoid arthritis_Homo sapiens_hsa053231.02740437
64Phenylalanine metabolism_Homo sapiens_hsa003601.02359045
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01487268
66Long-term potentiation_Homo sapiens_hsa047201.00258088
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99269362
68Homologous recombination_Homo sapiens_hsa034400.98455460
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97678693
70Ras signaling pathway_Homo sapiens_hsa040140.97278541
71Regulation of autophagy_Homo sapiens_hsa041400.96640612
72Long-term depression_Homo sapiens_hsa047300.96565899
73Tuberculosis_Homo sapiens_hsa051520.96113506
74Hepatitis C_Homo sapiens_hsa051600.94236322
75Type I diabetes mellitus_Homo sapiens_hsa049400.93114270
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93036925
77Melanogenesis_Homo sapiens_hsa049160.92929704
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.92276392
79Mineral absorption_Homo sapiens_hsa049780.90931017
80Huntingtons disease_Homo sapiens_hsa050160.90921781
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89810096
82Gastric acid secretion_Homo sapiens_hsa049710.89133202
83Olfactory transduction_Homo sapiens_hsa047400.87785620
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87080542
85Salivary secretion_Homo sapiens_hsa049700.85024094
86ErbB signaling pathway_Homo sapiens_hsa040120.84032415
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83393724
88Fanconi anemia pathway_Homo sapiens_hsa034600.83150319
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82062659
90Peroxisome_Homo sapiens_hsa041460.81879146
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.81517991
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80273635
93Circadian rhythm_Homo sapiens_hsa047100.79448493
94p53 signaling pathway_Homo sapiens_hsa041150.79366633
95RNA degradation_Homo sapiens_hsa030180.75390043
96Oxytocin signaling pathway_Homo sapiens_hsa049210.75005982
97Pancreatic secretion_Homo sapiens_hsa049720.72912703
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72304186
99Basal cell carcinoma_Homo sapiens_hsa052170.71323247
100Malaria_Homo sapiens_hsa051440.70572437
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.70206560
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70011866
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69515103
104beta-Alanine metabolism_Homo sapiens_hsa004100.69296635
105Platelet activation_Homo sapiens_hsa046110.67327346
106Synaptic vesicle cycle_Homo sapiens_hsa047210.67047784
107Ribosome_Homo sapiens_hsa030100.66436288
108Glioma_Homo sapiens_hsa052140.66180356
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64908688
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64840964
111Amoebiasis_Homo sapiens_hsa051460.64550658
112Dorso-ventral axis formation_Homo sapiens_hsa043200.64223544
113Dopaminergic synapse_Homo sapiens_hsa047280.62946713
114Phagosome_Homo sapiens_hsa041450.62500929
115Toxoplasmosis_Homo sapiens_hsa051450.59288393
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58672802
117ECM-receptor interaction_Homo sapiens_hsa045120.58394149
118Osteoclast differentiation_Homo sapiens_hsa043800.56937767
119TNF signaling pathway_Homo sapiens_hsa046680.56413530
120Allograft rejection_Homo sapiens_hsa053300.56123660
121Asthma_Homo sapiens_hsa053100.56115839
122Salmonella infection_Homo sapiens_hsa051320.55978921
123Hippo signaling pathway_Homo sapiens_hsa043900.55606462
124African trypanosomiasis_Homo sapiens_hsa051430.54705670
125Lysosome_Homo sapiens_hsa041420.54550713
126Calcium signaling pathway_Homo sapiens_hsa040200.54447582
127Graft-versus-host disease_Homo sapiens_hsa053320.54267256
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.54214454
129Autoimmune thyroid disease_Homo sapiens_hsa053200.54020125
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53989692
131Rap1 signaling pathway_Homo sapiens_hsa040150.53800705
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50953250
133Sulfur relay system_Homo sapiens_hsa041220.50449863
134Leishmaniasis_Homo sapiens_hsa051400.50348754
135Metabolic pathways_Homo sapiens_hsa011000.50014668
136Acute myeloid leukemia_Homo sapiens_hsa052210.49863897
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49843069
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49354432
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48926582
140Wnt signaling pathway_Homo sapiens_hsa043100.48772402
141Estrogen signaling pathway_Homo sapiens_hsa049150.47349637
142Proteoglycans in cancer_Homo sapiens_hsa052050.47275674
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46675612
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44998802
145Cocaine addiction_Homo sapiens_hsa050300.43684586
146Legionellosis_Homo sapiens_hsa051340.43414866
147TGF-beta signaling pathway_Homo sapiens_hsa043500.43385410
148Ovarian steroidogenesis_Homo sapiens_hsa049130.42851007
149Glycerolipid metabolism_Homo sapiens_hsa005610.42798096
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42326860
151cAMP signaling pathway_Homo sapiens_hsa040240.41149517
152MicroRNAs in cancer_Homo sapiens_hsa052060.41080389
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40531822
154Amphetamine addiction_Homo sapiens_hsa050310.40228079
155Primary immunodeficiency_Homo sapiens_hsa053400.36481978
156Sulfur metabolism_Homo sapiens_hsa009200.35966735
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35683112
158Purine metabolism_Homo sapiens_hsa002300.33962174

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